MCID: STS002
MIFTS: 50

Situs Inversus

Categories: Rare diseases

Aliases & Classifications for Situs Inversus

MalaCards integrated aliases for Situs Inversus:

Name: Situs Inversus 12 53 29 55 44 15
Situs Inversus Viscerum 12 53
Complete Transposition 12
Laterality Sequence 12
Siv 53

Classifications:



External Ids:

Disease Ontology 12 DOID:758
ICD10 33 Q89.3
ICD9CM 35 759.3
MeSH 44 D012857
NCIt 50 C87121
UMLS 73 C0037221

Summaries for Situs Inversus

NIH Rare Diseases : 53 Situs inversus is a condition in which the arrangement of the internal organs is a mirror image of normal anatomy. It can occur alone (isolated, with no other abnormalities or conditions) or it can occur as part of a syndrome with various other defects. Congenital heart defects are present in about 5-10% of affected people. The underlying cause and genetics of situs inversus are complex. Familial cases have been reported.

MalaCards based summary : Situs Inversus, also known as situs inversus viscerum, is related to dextrocardia with situs inversus and heterotaxy. An important gene associated with Situs Inversus is DNAI1 (Dynein Axonemal Intermediate Chain 1). The drugs Spironolactone and diuretics have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related phenotypes are cellular and growth/size/body region

Wikipedia : 76 Situs inversus (also called situs transversus or oppositus) is a congenital condition in which the major... more...

Related Diseases for Situs Inversus

Diseases related to Situs Inversus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 309)
# Related Disease Score Top Affiliating Genes
1 dextrocardia with situs inversus 33.4 CFAP53 NODAL
2 heterotaxy 31.4 CFAP53 NODAL
3 dextrocardia 31.4 CFAP53 DNAI1 NODAL
4 ciliary dyskinesia, primary, 1 30.6 ARMC4 CCDC40 DNAAF1 DNAH5 DNAI1 DNAI2
5 renal-hepatic-pancreatic dysplasia 28.9 INVS NODAL
6 kartagener syndrome 27.9 ARMC4 CCDC39 CCDC40 DNAAF1 DNAH11 DNAH5
7 visceral heterotaxy 27.1 ARMC4 CCDC39 CCDC40 CFAP53 DNAAF1 DNAH11
8 primary ciliary dyskinesia 26.6 ARMC4 CCDC39 CCDC40 DNAAF1 DNAH11 DNAH5
9 retinitis pigmentosa with or without situs inversus 12.5
10 hypoglossia with situs inversus 12.3
11 aglossia and situs inversus 12.2
12 situs inversus totalis with cystic dysplasia of kidneys and pancreas 12.1
13 jeune syndrome situs inversus 12.1
14 marfanoid habitus with situs inversus 12.0
15 chondrodysplasia situs inversus imperforate anus polydactyly 12.0
16 heterotaxy, visceral, 5, autosomal 11.9
17 ciliary dyskinesia, primary, 3 11.9
18 ciliary dyskinesia, primary, 9 11.9
19 isolated levocardia 11.9
20 ciliary dyskinesia, primary, 5 11.9
21 ciliary dyskinesia, primary, 7 11.9
22 ciliary dyskinesia, primary, 18 11.9
23 ciliary dyskinesia, primary, 23 11.9
24 ciliary dyskinesia, primary, 10 11.8
25 ciliary dyskinesia, primary, 16 11.8
26 ciliary dyskinesia, primary, 17 11.8
27 ciliary dyskinesia, primary, 19 11.8
28 ciliary dyskinesia, primary, 20 11.8
29 ciliary dyskinesia, primary, 25 11.8
30 ciliary dyskinesia, primary, 26 11.8
31 ciliary dyskinesia, primary, 27 11.8
32 ciliary dyskinesia, primary, 28 11.8
33 ciliary dyskinesia, primary, 35 11.8
34 levocardia 11.8
35 agnathia-otocephaly complex 11.8
36 ciliary dyskinesia, primary, 2 11.8
37 ciliary dyskinesia, primary, 11 11.8
38 ciliary dyskinesia, primary, 12 11.8
39 ciliary dyskinesia, primary, 13 11.8
40 ciliary dyskinesia, primary, 14 11.8
41 ciliary dyskinesia, primary, 15 11.8
42 ciliary dyskinesia, primary, 21 11.8
43 ciliary dyskinesia, primary, 22 11.8
44 ciliary dyskinesia, primary, 29 11.8
45 ciliary dyskinesia, primary, 30 11.8
46 ciliary dyskinesia, primary, 36, x-linked 11.7
47 ciliary dyskinesia, primary, 24 11.7
48 ciliary dyskinesia, primary, 37 11.7
49 heterotaxy, visceral, 1, x-linked 11.7
50 ciliary dyskinesia, primary, 4 11.7

Graphical network of the top 20 diseases related to Situs Inversus:



Diseases related to Situs Inversus

Symptoms & Phenotypes for Situs Inversus

MGI Mouse Phenotypes related to Situs Inversus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.16 DNAH5 CCDC39 DNAI1 CCDC40 DNAI2 DNAH11
2 growth/size/body region MP:0005378 10.11 DNAH5 CCDC39 DNAI1 CCDC40 DNAI2 DNAH11
3 cardiovascular system MP:0005385 10.08 DNAH5 CCDC39 DNAI1 DNAH11 ARMC4 NODAL
4 mortality/aging MP:0010768 9.96 DNAH5 CCDC39 CCDC40 DNAI1 DNAAF1 DNAH11
5 craniofacial MP:0005382 9.91 DNAH5 CCDC39 DNAI1 DNAAF1 DNAH11 NODAL
6 digestive/alimentary MP:0005381 9.88 ARMC4 DNAH5 CCDC39 DNAH11 NODAL INVS
7 nervous system MP:0003631 9.81 DNAH5 CCDC39 DNAI1 CCDC40 DNAAF1 ARMC4
8 liver/biliary system MP:0005370 9.72 DNAH11 DNAH5 CCDC39 INVS NODAL
9 renal/urinary system MP:0005367 9.35 DNAH5 CCDC39 CCDC40 DNAH11 INVS
10 respiratory system MP:0005388 9.32 DNAH5 CCDC39 DNAI1 CCDC40 DNAI2 DNAH11

Drugs & Therapeutics for Situs Inversus

Drugs for Situs Inversus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2 diuretics Phase 4
3 Mineralocorticoid Receptor Antagonists Phase 4
4 Mineralocorticoids Phase 4
5 Natriuretic Agents Phase 4
6 Natriuretic Peptide, Brain Phase 4
7 Hormone Antagonists Phase 4
8 Hormones Phase 4
9 Diuretics, Potassium Sparing Phase 4
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
11 Pharmaceutical Solutions Phase 2
12 Antihypertensive Agents Phase 2
13
Dobutamine Approved Not Applicable 34368-04-2 36811
14
Nitric Oxide Approved ,Not Applicable 10102-43-9 145068 160954
15
Menthol Approved Not Applicable 2216-51-5 16666
16
Mechlorethamine Approved, Investigational 51-75-2 4033
17 Respiratory System Agents ,Not Applicable
18 Neurotransmitter Agents ,Not Applicable
19 Vasodilator Agents ,Not Applicable
20 Anti-Asthmatic Agents ,Not Applicable
21 Endothelium-Dependent Relaxing Factors ,Not Applicable
22 Peripheral Nervous System Agents ,Not Applicable
23 Antioxidants ,Not Applicable
24 Protective Agents ,Not Applicable
25 Autonomic Agents ,Not Applicable
26 Bronchodilator Agents ,Not Applicable
27 Liver Extracts

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Water Immersion in Right-Sided Heart Failure: A Pilot Study Completed NCT00654264 Phase 4
2 Spironolactone Therapy in Chronic Stable Right HF Trial Recruiting NCT03344159 Phase 4 Spironolactone;Placebo
3 Ambrisentan in Single Ventricle Active, not recruiting NCT02080637 Phase 2 Ambrisentan
4 Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia Active, not recruiting NCT02871778 Phase 2 VX-371;Hypertonic Saline;Placebo (0.17% saline);Ivacaftor
5 Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young Adults Unknown status NCT02415491 Not Applicable
6 Early Detection and Characterization of Primary Ciliary Dyskinesia Unknown status NCT01070914
7 Screening for Primary Ciliary Dyskinesia Using Nasal Nitric Oxide Unknown status NCT00739817
8 Comparison of On-line and Off-line Measurements of Exhaled Nitric Oxide (NO) Unknown status NCT00686309
9 Dyskinesia, Heterotaxy and Congenital Heart Disease Completed NCT00608556
10 MRI Study After Arterial Switch Operation in Patients With Transposition of the Great Arteries Completed NCT01916499
11 Physical Training in Transposition of the Great Arteries Completed NCT00837603 Not Applicable
12 Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart Valves Completed NCT02119442 Not Applicable
13 Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery Completed NCT02831907
14 Evaluation of Monitoring TECHNOlogies in the PERI-OPerative Care of Cardiac Surgical Patients Completed NCT02658006
15 NIOX VERO Nasal Application in Primary Ciliary Dyskinesia Completed NCT02622061
16 Otolith Function in Patients With Primary Ciliary Dyskinesia Completed NCT01246258
17 Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary Dyskinesia Completed NCT01155115 Not Applicable
18 Diagnosis of Primary Ciliary Dyskinesia Completed NCT00783887
19 Non-invasive Assessment of Liver Stiffness/Fibrosis by Transient Elastography (Fibroscan) in Patients With Left and/or Right Sided Heart Failure Completed NCT00777725
20 Genetic Study of Patients With Primary Ciliary Dyskinesia Completed NCT00005650
21 Fibrosis, Valvular and Ventricular Function in Patients With TGA Recruiting NCT02588989
22 Molecular Genetics of Heterotaxy and Related Congenital Heart Defects Recruiting NCT02432079
23 International Primary Ciliary Dyskinesia Cohort Recruiting NCT03517865
24 Bacteriological Link Between Upper and Lower Airways in Cystic Fibrosis and Primary Ciliary Dyskinesia Recruiting NCT03494894
25 Respiratory Muscle Strength, Exercise Capacity and Physical Activity Levels in Children Primary Ciliary Dyskinesia Recruiting NCT03370029
26 Multiple Breath Washout, a Clinimetric Dataset Recruiting NCT03320382
27 MRI in Cystic Fibrosis and Primary Ciliary Dyskinesia Recruiting NCT03279965
28 Registry for Primary Ciliary Dyskinesia Recruiting NCT03271840
29 High Resolution Micro OCT Imaging Recruiting NCT03256773
30 International Prospective Patient Registry for Primary Ciliary Dyskinesia (PCD) Recruiting NCT02419365
31 Genetics of Primary Ciliary Dyskinesia Recruiting NCT02389049
32 Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease Recruiting NCT00807482
33 Clinical and Molecular Investigations Into Ciliopathies Active, not recruiting NCT00068224
34 Severe and Transient Hypoxemia During Selective Intra-arterial Chemotherapy for Retinoblastoma in Children: Evaluation of the Right-sided Heart Function. Active, not recruiting NCT03559894
35 Open Lung Strategy in Critically Ill Morbid Obese Patients Active, not recruiting NCT02503241 Not Applicable
36 Long-term Lung Function and Disease Progression in Children With Early Onset Primary Ciliary Dyskinesia Lung Disease Active, not recruiting NCT00722878
37 Evaluating Progression of and Diagnostic Tools for Primary Ciliary Dyskinesia in Children and Adolescents Active, not recruiting NCT00450918
38 Rare Genetic Disorders of the Breathing Airways Active, not recruiting NCT00323167
39 Late Function After Surgery for Transposition of the Great Arteries Enrolling by invitation NCT03078413
40 Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters Not yet recruiting NCT03469843
41 Registry Study on Primary Ciliary Dyskinesia in Chinese Children Not yet recruiting NCT02704455
42 In Vivo Measurements of Nasal Ciliary Beat Frequency by Using Interferometry Not yet recruiting NCT02699177
43 Chest Physiotherapy and Lung Function in Primary Ciliary Dyskinesia Withdrawn NCT01929356 Not Applicable

Search NIH Clinical Center for Situs Inversus

Cochrane evidence based reviews: situs inversus

Genetic Tests for Situs Inversus

Genetic tests related to Situs Inversus:

# Genetic test Affiliating Genes
1 Situs Inversus 29

Anatomical Context for Situs Inversus

MalaCards organs/tissues related to Situs Inversus:

41
Heart, Liver, Lung, Kidney, Brain, Colon, Pancreas

Publications for Situs Inversus

Articles related to Situs Inversus:

(show top 50) (show all 816)
# Title Authors Year
1
Superficial Spreading-type Gastric Cancer with <i>Situs Inversus Totalis</i>. ( 29695579 )
2018
2
Laparoscopic biliopancreatic diversion for a morbidly obese patient with situs inversus totalis: Case report. ( 29860118 )
2018
3
Robot-assisted distal gastrectomy with lymph node dissection for gastric cancer in a patient with situs inversus partialis: a case report with video file. ( 29441475 )
2018
4
Laparoscopic colon resection in patients with situs inversus totalis: Is it the same operation as in patients without situs inversus totalis? ( 29737309 )
2018
5
Laparoscopic Roux-en-Y gastric bypass in a patient with situs inversus totalis: Case report, technical tips and review of the literature. ( 29573597 )
2018
6
Case report about a successful full robotic radical gastric cancer surgery with intracorporeal robot-sewn anastomosis in a patient with situs inversus totalis and a two-and-a-half-year follow-up study. ( 29499701 )
2018
7
Thoracoscopic total esophagogastrectomy with supercharged colon interposition for the treatment of esophageal adenocarcinoma in situs inversus. ( 29436979 )
2018
8
Transcatheter Aortic Valve Replacement in a Patient with Dextrocardia and Situs Inversus Totalis. ( 29908190 )
2018
9
Gastric cancer with situs inversus totalis: does it really create difficulties for surgeons? ( 29657611 )
2018
10
Incidental adult polysplenia with situs inversus, interrupted inferior vena cava with azygos continuation, patent ductus arteriosus, and aortic branches variations: a case report. ( 29607204 )
2018
11
Successful ERCP for management of traumatic pancreatic disruption in a patient with situs inversus. ( 29552451 )
2018
12
Situs Inversus Totalis and Cholangiocarcinoma of the Gallbladder Detected by 18F-FDG PET/CT. ( 29538026 )
2018
13
Situs inversus totalis with solid pseudopapillary pancreatic tumor: A case report and review of literature. ( 29561447 )
2018
14
Variations in vascular anatomy and unilateral adrenal agenesis in a female cadaver with situs inversus totalis. ( 29931532 )
2018
15
Endoscopic submucosal dissection of early gastric cancer via inverted overtube in a patient with situs inversus totalis: a case report. ( 29756022 )
2018
16
A twin study of cilioretinal arteries, tilted discs and situs inversus. ( 29242987 )
2018
17
Brain structural and functional asymmetry in human situs inversus totalis. ( 29302744 )
2018
18
Atypical brain functional segregation is more frequent in situs inversus totalis. ( 29864592 )
2018
19
Laparoscopic sigmoidectomy in a case of sigmoid colon cancer with situs inversus totalis. ( 29601667 )
2018
20
Deranged Myocyte Microstructure in Situs Inversus Totalis Demonstrated by Diffusion Tensor Cardiac Magnetic Resonance. ( 29361490 )
2018
21
Laparoscopic radical nephrectomy for a right renal tumor with renal vein tumor thrombus in a patient with situs inversus totalis. ( 29791972 )
2018
22
Portal vein embolisation in a patient with situs inversus. ( 29348286 )
2018
23
Video-assisted thoracoscopic bisegmentectomies for double primary lung cancers in a patient with situs inversus totalis. ( 29671216 )
2018
24
A case of ventricular septal defect detected after myomectomy by intra-operative transesophageal echocardiography in patient with situs inversus and double-chambered right ventricle. ( 29740751 )
2018
25
Laparoscopic cholecystectomy with choledochoduodenostomy in a patient with situs inversus totalis. ( 29882522 )
2018
26
Situs Inversus with Levocardia and Congenitally Corrected Transposition of Great Vessels in a 35 year old Male: A Case report. ( 28243408 )
2017
27
Laparoscopic total gastrectomy for advanced gastric cancer in a patient with situs inversus totalis. ( 28677888 )
2017
28
How Do I Do a Laparoscopic One-Anastomosis Gastric Bypass in a Patient with Situs Inversus Totalis. ( 28560525 )
2017
29
Management of Complicated Choledochal Cyst in an Adult with Situs Inversus Totalis: Diagnostic Difficulties and Technical Notes. ( 29089712 )
2017
30
Mens inversus in corpore inverso? Language lateralization in a boy with situs inversus totalis. ( 28709112 )
2017
31
A colovesical fistula with a persistent descending mesocolon due to partial situs inversus: A case report. ( 28654851 )
2017
32
Situs inversus: When an incidental finding is not so incidental. ( 28670800 )
2017
33
Ablation of epicardial ventricular tachycardia in a chagasic patient with situs inversus totalis: A case report. ( 29296575 )
2017
34
Gastric cancer in a situs inversus totalis patient with multiple intestinal and vessel variations related to gastrectomy surgery: A case report and literature review. ( 28953685 )
2017
35
Neonatal intestinal obstruction associated with situs inversus totalis: two case reports and a review of the literature. ( 28918753 )
2017
36
Surgical challenge in situs inversus with dextrocardia and Lutembacher syndrome. ( 29214824 )
2017
37
Congenital Duodenal Obstruction, Situs Inversus Totalis, and Gastric Perforation in a Neonate. ( 28770132 )
2017
38
Mandibular symphyseal midline distraction osteogenesis for micrognathia associated with aglossia and situs inversus totalis. ( 28610820 )
2017
39
Left side approach for aortic valve replacement in patient with dextrocardia and situs inversus totalis. ( 28983174 )
2017
40
Laparoscopic hemicolectomy for a patient with situs inversus totalis: A case report. ( 29055878 )
2017
41
Radiofrequency Pulmonary Vein Isolation in a Patient with Dextrocardia With Situs Inversus Totalis. ( 28462889 )
2017
42
Double-balloon enteroscopy-assisted ERCP in situs inversus with Roux-en-Y hepaticojejunostomy for complex anastomotic stricture dilated with Soehendra stent retriever. ( 28068702 )
2017
43
Pulmonary Vein Isolation for Treatment of Paroxysmal Atrial Fibrillation on Patient with Situs Inversus Totalis. ( 29250224 )
2017
44
A patient with chronic myeloid leukemia and situs inversus totalis: A case report. ( 29344183 )
2017
45
Successful access to the ampulla for endoscopic retrograde cholangiopancreatography in patients with situs inversus totalis: a case report. ( 29183311 )
2017
46
Dextrocardia With Situs Inversus and Levo-Transposition of Great Vessels. ( 28641729 )
2017
47
Images in Anesthesiology: Mirror Image: A Patient with Situs Inversus Totalis. ( 27977454 )
2017
48
Robotic Assisted Distal Gastrectomy for Gastric Cancer in a Patient with Situs Inversus Totalis: with Video. ( 28900793 )
2017
49
ERCP and Laparoscopic cholecystectomy in a patient with situs inversus totalis. ( 28651902 )
2017
50
Video-assisted thoracic surgery and jejunal reconstruction in a case of situs inversus totalis with esophageal cancer. ( 28681978 )
2017

Variations for Situs Inversus

Expression for Situs Inversus

Search GEO for disease gene expression data for Situs Inversus.

Pathways for Situs Inversus

GO Terms for Situs Inversus

Cellular components related to Situs Inversus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.91 ARL2BP ARMC4 DNAAF1 DNAH11 DNAH5 DNAI1
2 cell projection GO:0042995 9.9 ARL2BP ARMC4 CCDC40 CFAP53 DNAAF1 DNAH11
3 microtubule GO:0005874 9.8 DNAH11 DNAH5 DNAI1 DNAI2 INVS
4 dynein complex GO:0030286 9.62 DNAH11 DNAH5 DNAI1 DNAI2
5 outer dynein arm GO:0036157 9.54 DNAH5 DNAI1 DNAI2
6 axoneme GO:0005930 9.5 ARMC4 CCDC39 CCDC40 DNAAF1 DNAH11 DNAH5
7 9+2 motile cilium GO:0097729 9.43 DNAH11 DNAH5
8 cilium GO:0005929 9.36 ARL2BP ARMC4 CCDC39 CCDC40 CFAP53 DNAAF1
9 cytoplasm GO:0005737 10.2 ARL2BP ARMC4 CCDC40 DNAAF1 DNAH11 DNAH5

Biological processes related to Situs Inversus according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.87 ARMC4 DNAH11 DNAI1 NODAL
2 cilium assembly GO:0060271 9.86 CFAP53 DNAAF1 DNAH5 DNAI2
3 microtubule-based movement GO:0007018 9.85 DNAH11 DNAH5 DNAI1 DNAI2
4 lung development GO:0030324 9.83 CCDC39 CCDC40 DNAAF1 NODAL
5 heart looping GO:0001947 9.78 CCDC39 CCDC40 DNAAF1 NODAL
6 flagellated sperm motility GO:0030317 9.77 CCDC39 CCDC40 DNAH11 DNAH5 DNAI1
7 cell projection organization GO:0030030 9.76 ARMC4 DNAI1 DNAI2
8 outer dynein arm assembly GO:0036158 9.72 ARMC4 DNAAF1 DNAH5 DNAI1 DNAI2
9 motile cilium assembly GO:0044458 9.71 CCDC39 CCDC40 DNAAF1
10 determination of left/right symmetry GO:0007368 9.7 ARMC4 CFAP53 DNAH11 DNAH5 DNAI1 DNAI2
11 inner dynein arm assembly GO:0036159 9.69 CCDC39 CCDC40 DNAAF1
12 axonemal dynein complex assembly GO:0070286 9.67 CCDC39 CCDC40 DNAAF1
13 epithelial cilium movement involved in determination of left/right asymmetry GO:0060287 9.65 CCDC39 CCDC40 CFAP53 DNAAF1 DNAH11
14 determination of digestive tract left/right asymmetry GO:0071907 9.63 CCDC39 CCDC40 DNAAF1
15 determination of liver left/right asymmetry GO:0071910 9.61 CCDC39 CCDC40 DNAAF1
16 epithelial cilium movement GO:0003351 9.58 CCDC40 DNAI1
17 determination of pancreatic left/right asymmetry GO:0035469 9.58 CCDC39 CCDC40 DNAAF1
18 regulation of cilium beat frequency GO:0003356 9.35 ARMC4 CCDC39 CCDC40 DNAAF1 DNAH11
19 cilium movement GO:0003341 9.28 ARMC4 CCDC39 CCDC40 CFAP53 DNAAF1 DNAH11

Molecular functions related to Situs Inversus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 9.43 DNAI1 DNAI2
2 microtubule motor activity GO:0003777 9.43 DNAH11 DNAH5 DNAI2
3 dynein light intermediate chain binding GO:0051959 9.4 DNAH11 DNAH5
4 dynein intermediate chain binding GO:0045505 9.37 DNAH11 DNAH5
5 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 9.32 DNAH11 DNAH5
6 motor activity GO:0003774 9.26 DNAH11 DNAH5 DNAI1 DNAI2
7 dynein heavy chain binding GO:0045504 9.16 DNAI1 DNAI2
8 dynein light chain binding GO:0045503 8.92 DNAH11 DNAH5 DNAI1 DNAI2

Sources for Situs Inversus

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10 dbSNP
11 DGIdb
17 ExPASy
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64 QIAGEN
69 SNOMED-CT via HPO
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74 UMLS via Orphanet
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