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SIV
MCID: STS002
MIFTS: 49

Situs Inversus (SIV)

Categories: Rare diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Situs Inversus

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MalaCards integrated aliases for Situs Inversus:

Name: Situs Inversus 12 53 29 55 44 15
Situs Inversus Viscerum 12 53
Complete Transposition 12
Laterality Sequence 12
Siv 53

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:758
ICD10 33 Q89.3
ICD9CM 35 759.3
MeSH 44 D012857
NCIt 50 C87121
SNOMED-CT 68 27317008 43876007
UMLS 73 C0037221
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Summaries for Situs Inversus

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NIH Rare Diseases : 53 Situs inversus is a condition in which the arrangement of the internal organs is a mirror image of normal anatomy. It can occur alone (isolated, with no other abnormalities or conditions) or it can occur as part of a syndrome with various other defects. Congenital heart defects are present in about 5-10% of affected people. The underlying cause and genetics of situs inversus are complex. Familial cases have been reported.

MalaCards based summary : Situs Inversus, also known as situs inversus viscerum, is related to dextrocardia with situs inversus and ciliary dyskinesia, primary, 1. An important gene associated with Situs Inversus is DNAH11 (Dynein Axonemal Heavy Chain 11). The drugs Spironolactone and Natriuretic Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related phenotypes are cellular and growth/size/body region

Wikipedia : 76 Situs inversus (also called situs transversus or oppositus) is a congenital condition in which the major... more...

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Related Diseases for Situs Inversus

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Diseases related to Situs Inversus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 376)
# Related Disease Score Top Affiliating Genes
1 dextrocardia with situs inversus 34.1 CFAP53 NODAL
2 ciliary dyskinesia, primary, 1 32.6 ARMC4 CCDC40 DNAAF1 DNAH5 DNAI1 DNAI2
3 heterotaxy 32.3 CFAP53 NODAL
4 dextrocardia 32.3 CFAP53 DNAI1 NODAL
5 kartagener syndrome 31.5 ARMC4 CCDC39 CCDC40 DNAAF1 DNAH11 DNAH5
6 visceral heterotaxy 31.5 ARMC4 CCDC39 CCDC40 CFAP53 DNAAF1 DNAH11
7 bronchiectasis 30.2 CCDC40 DNAH5 DNAI1
8 primary ciliary dyskinesia 29.6 ARMC4 CCDC39 DNAAF1 DNAH11 DNAH5 DNAI1
9 renal-hepatic-pancreatic dysplasia 29.5 INVS NODAL
10 retinitis pigmentosa 82 with or without situs inversus 12.6
11 hypoglossia with situs inversus 12.5
12 aglossia and situs inversus 12.3
13 situs inversus totalis with cystic dysplasia of kidneys and pancreas 12.3
14 jeune syndrome situs inversus 12.2
15 marfanoid habitus with situs inversus 12.2
16 chondrodysplasia situs inversus imperforate anus polydactyly 12.2
17 heterotaxy, visceral, 5, autosomal 12.1
18 ciliary dyskinesia, primary, 3 12.1
19 ciliary dyskinesia, primary, 9 12.0
20 isolated levocardia 12.0
21 ciliary dyskinesia, primary, 5 12.0
22 ciliary dyskinesia, primary, 7 12.0
23 ciliary dyskinesia, primary, 18 12.0
24 ciliary dyskinesia, primary, 23 12.0
25 ciliary dyskinesia, primary, 10 12.0
26 ciliary dyskinesia, primary, 16 12.0
27 ciliary dyskinesia, primary, 17 12.0
28 ciliary dyskinesia, primary, 19 12.0
29 ciliary dyskinesia, primary, 20 12.0
30 ciliary dyskinesia, primary, 25 12.0
31 ciliary dyskinesia, primary, 26 12.0
32 ciliary dyskinesia, primary, 27 12.0
33 ciliary dyskinesia, primary, 28 12.0
34 ciliary dyskinesia, primary, 35 12.0
35 levocardia 12.0
36 ciliary dyskinesia, primary, 2 11.9
37 ciliary dyskinesia, primary, 11 11.9
38 ciliary dyskinesia, primary, 12 11.9
39 ciliary dyskinesia, primary, 13 11.9
40 ciliary dyskinesia, primary, 14 11.9
41 ciliary dyskinesia, primary, 15 11.9
42 ciliary dyskinesia, primary, 21 11.9
43 ciliary dyskinesia, primary, 22 11.9
44 ciliary dyskinesia, primary, 29 11.9
45 ciliary dyskinesia, primary, 30 11.9
46 agnathia-otocephaly complex 11.9
47 ciliary dyskinesia, primary, 36, x-linked 11.9
48 ciliary dyskinesia, primary, 24 11.9
49 ciliary dyskinesia, primary, 37 11.9
50 ciliary dyskinesia, primary, 38 11.9

Graphical network of the top 20 diseases related to Situs Inversus:



Diseases related to Situs Inversus
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Symptoms & Phenotypes for Situs Inversus

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MGI Mouse Phenotypes related to Situs Inversus:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 ARMC4 CCDC39 CCDC40 DNAH11 DNAH5 DNAI1
2 growth/size/body region MP:0005378 10.21 ARMC4 CCDC39 CCDC40 CFAP53 DNAH11 DNAH5
3 cardiovascular system MP:0005385 10.18 ARMC4 CCDC39 CFAP53 DNAH11 DNAH5 DNAI1
4 hematopoietic system MP:0005397 10.01 ARMC4 CCDC39 CFAP53 DNAH11 DNAH5 DNAI1
5 craniofacial MP:0005382 9.97 CCDC39 DNAAF1 DNAH11 DNAH5 DNAI1 NODAL
6 immune system MP:0005387 9.97 ARMC4 CCDC39 CFAP53 DNAH11 DNAH5 DNAI1
7 mortality/aging MP:0010768 9.96 ARMC4 CCDC39 CCDC40 DNAAF1 DNAH11 DNAH5
8 digestive/alimentary MP:0005381 9.95 ARMC4 CCDC39 DNAH11 DNAH5 INVS NODAL
9 embryo MP:0005380 9.93 CCDC40 CFAP53 DNAH11 INVS NODAL TTC25
10 nervous system MP:0003631 9.85 ARMC4 CCDC39 CCDC40 CFAP53 DNAAF1 DNAH5
11 liver/biliary system MP:0005370 9.8 CCDC39 CFAP53 DNAH11 DNAH5 INVS NODAL
12 respiratory system MP:0005388 9.36 ARMC4 CCDC39 CCDC40 CFAP53 DNAH11 DNAH5
13 renal/urinary system MP:0005367 9.35 CCDC39 CCDC40 DNAH11 DNAH5 INVS
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Drugs & Therapeutics for Situs Inversus

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Drugs for Situs Inversus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
2 Natriuretic Agents Phase 4
3 diuretics Phase 4
4 Diuretics, Potassium Sparing Phase 4
5 Natriuretic Peptide, Brain Phase 4
6 Mineralocorticoids Phase 4
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
8 Mineralocorticoid Receptor Antagonists Phase 4
9 Hormone Antagonists Phase 4
10 Hormones Phase 4
11
Nitric Oxide Approved Phase 3,Not Applicable 10102-43-9 145068
12 Vasodilator Agents Phase 3,Phase 2,Not Applicable
13 Autonomic Agents Phase 3,Not Applicable
14 Free Radical Scavengers Phase 3,Not Applicable
15 Anti-Asthmatic Agents Phase 3,Not Applicable
16 Antioxidants Phase 3,Not Applicable
17 Neurotransmitter Agents Phase 3,Not Applicable
18 Endothelium-Dependent Relaxing Factors Phase 3,Not Applicable
19 Respiratory System Agents Phase 3,Not Applicable
20 Peripheral Nervous System Agents Phase 3,Not Applicable
21 Bronchodilator Agents Phase 3,Not Applicable
22 Protective Agents Phase 3,Phase 2,Not Applicable
23
Ivacaftor Approved Phase 2 873054-44-5 16220172
24
Ambrisentan Approved, Investigational Phase 2 177036-94-1 6918493
25 Simendan Investigational Phase 2 131741-08-7
26 Pharmaceutical Solutions Phase 2
27 Phosphodiesterase Inhibitors Phase 2
28 Cardiotonic Agents Phase 2
29 Anti-Arrhythmia Agents Phase 2
30 Antihypertensive Agents Phase 2
31
Dobutamine Approved Not Applicable 34368-04-2 36811
32
Mechlorethamine Approved, Investigational 51-75-2 4033
33 Liver Extracts
34 3-Iodobenzylguanidine

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Water Immersion in Right-Sided Heart Failure: A Pilot Study Completed NCT00654264 Phase 4
2 Spironolactone Therapy in Chronic Stable Right HF Trial Recruiting NCT03344159 Phase 4 Spironolactone;Placebo
3 Nitric Oxide During Bypass for Arterial Switch Operation Recruiting NCT03661385 Phase 3 Nitric Oxide
4 Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia Completed NCT02871778 Phase 2 VX-371;Hypertonic Saline;Placebo (0.17% saline);Ivacaftor
5 Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients Recruiting NCT03624010 Phase 2 Levosimendan 2.5 mg/ml Injectable Solution
6 Ambrisentan in Single Ventricle Active, not recruiting NCT02080637 Phase 2 Ambrisentan
7 Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young Adults Unknown status NCT02415491 Not Applicable
8 Early Detection and Characterization of Primary Ciliary Dyskinesia Unknown status NCT01070914
9 Screening for Primary Ciliary Dyskinesia Using Nasal Nitric Oxide Unknown status NCT00739817
10 Comparison of On-line and Off-line Measurements of Exhaled Nitric Oxide (NO) Unknown status NCT00686309
11 Dyskinesia, Heterotaxy and Congenital Heart Disease Completed NCT00608556
12 Late Function After Surgery for Transposition of the Great Arteries Completed NCT03078413
13 MRI Study After Arterial Switch Operation in Patients With Transposition of the Great Arteries Completed NCT01916499
14 Physical Training in Transposition of the Great Arteries Completed NCT00837603 Not Applicable
15 Clinical and Molecular Investigations Into Ciliopathies Completed NCT00068224
16 Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart Valves Completed NCT02119442 Not Applicable
17 Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery Completed NCT02831907
18 Evaluation of Monitoring TECHNOlogies in the PERI-OPerative Care of Cardiac Surgical Patients Completed NCT02658006
19 NIOX VERO Nasal Application in Primary Ciliary Dyskinesia Completed NCT02622061
20 Otolith Function in Patients With Primary Ciliary Dyskinesia Completed NCT01246258
21 Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary Dyskinesia Completed NCT01155115 Not Applicable
22 Diagnosis of Primary Ciliary Dyskinesia Completed NCT00783887
23 Non-invasive Assessment of Liver Stiffness/Fibrosis by Transient Elastography (Fibroscan) in Patients With Left and/or Right Sided Heart Failure Completed NCT00777725
24 Genetic Study of Patients With Primary Ciliary Dyskinesia Completed NCT00005650
25 Acute Maternal Hyperoxygenation for Fetal Transposition of the Great Arteries (TGA) Recruiting NCT03771534 Not Applicable Oxygen gas
26 Fibrosis, Valvular and Ventricular Function in Patients With TGA Recruiting NCT02588989
27 Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters Recruiting NCT03469843
28 Molecular Genetics of Heterotaxy and Related Congenital Heart Defects Recruiting NCT02432079
29 WGS of Korean Idiopathic Bronchiectasis Recruiting NCT03809091
30 PCD New Gene Discovery Recruiting NCT03801395
31 Utility of PCD Diagnostics to Improve Clinical Care Recruiting NCT03704207 Not Applicable
32 Swiss Primary Ciliary Dyskinesia Registry Recruiting NCT03606200
33 International Primary Ciliary Dyskinesia Cohort Recruiting NCT03517865
34 Bacteriological Link Between Upper and Lower Airways in Cystic Fibrosis and Primary Ciliary Dyskinesia Recruiting NCT03494894
35 Respiratory Muscle Strength, Exercise Capacity and Physical Activity Levels in Children Primary Ciliary Dyskinesia Recruiting NCT03370029
36 Multiple Breath Washout, a Clinimetric Dataset Recruiting NCT03320382
37 MRI in Cystic Fibrosis and Primary Ciliary Dyskinesia Recruiting NCT03279965
38 Registry for Primary Ciliary Dyskinesia Recruiting NCT03271840
39 High Resolution Micro OCT Imaging Recruiting NCT03256773
40 International Prospective Patient Registry for Primary Ciliary Dyskinesia (PCD) Recruiting NCT02419365
41 Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease Recruiting NCT00807482
42 PRospective Observational Multicentre Study on VAriability of Lung Function in Stable PCD Patients Active, not recruiting NCT03704896
43 Severe and Transient Hypoxemia During Selective Intra-arterial Chemotherapy for Retinoblastoma in Children: Evaluation of the Right-sided Heart Function. Active, not recruiting NCT03559894
44 Open Lung Strategy in Critically Ill Morbid Obese Patients Active, not recruiting NCT02503241 Not Applicable
45 Genetics of Primary Ciliary Dyskinesia Active, not recruiting NCT02389049
46 Long-term Lung Function and Disease Progression in Children With Early Onset Primary Ciliary Dyskinesia Lung Disease Active, not recruiting NCT00722878
47 Evaluating Progression of and Diagnostic Tools for Primary Ciliary Dyskinesia in Children and Adolescents Active, not recruiting NCT00450918
48 Rare Genetic Disorders of the Breathing Airways Active, not recruiting NCT00323167
49 Registry Study on Primary Ciliary Dyskinesia in Chinese Children Not yet recruiting NCT02704455
50 In Vivo Measurements of Nasal Ciliary Beat Frequency by Using Interferometry Not yet recruiting NCT02699177

Search NIH Clinical Center for Situs Inversus

Cochrane evidence based reviews: situs inversus

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Genetic Tests for Situs Inversus

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Genetic tests related to Situs Inversus:

# Genetic test Affiliating Genes
1 Situs Inversus 29
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Anatomical Context for Situs Inversus

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MalaCards organs/tissues related to Situs Inversus:

41
Heart, Liver, Lung, Colon, Kidney, Brain, Pancreas
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Publications for Situs Inversus

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Articles related to Situs Inversus:

(show top 50) (show all 1115)
# Title Authors Year
1
Superficial Spreading-type Gastric Cancer with <i>Situs Inversus Totalis</i>. ( 29695579 )
2018
2
Laparoscopic biliopancreatic diversion for a morbidly obese patient with situs inversus totalis: Case report. ( 29860118 )
2018
3
Robot-assisted distal gastrectomy with lymph node dissection for gastric cancer in a patient with situs inversus partialis: a case report with video file. ( 29441475 )
2018
4
Laparoscopic colon resection in patients with situs inversus totalis: Is it the same operation as in patients without situs inversus totalis? ( 29737309 )
2018
5
Laparoscopic Roux-en-Y gastric bypass in a patient with situs inversus totalis: Case report, technical tips and review of the literature. ( 29573597 )
2018
6
Case report about a successful full robotic radical gastric cancer surgery with intracorporeal robot-sewn anastomosis in a patient with situs inversus totalis and a two-and-a-half-year follow-up study. ( 29499701 )
2018
7
Thoracoscopic total esophagogastrectomy with supercharged colon interposition for the treatment of esophageal adenocarcinoma in situs inversus. ( 29436979 )
2018
8
Transcatheter Aortic Valve Replacement in a Patient with Dextrocardia and Situs Inversus Totalis. ( 29908190 )
2018
9
Gastric cancer with situs inversus totalis: does it really create difficulties for surgeons? ( 29657611 )
2018
10
Incidental adult polysplenia with situs inversus, interrupted inferior vena cava with azygos continuation, patent ductus arteriosus, and aortic branches variations: a case report. ( 29607204 )
2018
11
Successful ERCP for management of traumatic pancreatic disruption in a patient with situs inversus. ( 29552451 )
2018
12
Situs Inversus Totalis and Cholangiocarcinoma of the Gallbladder Detected by 18F-FDG PET/CT. ( 29538026 )
2018
13
Situs inversus totalis with solid pseudopapillary pancreatic tumor: A case report and review of literature. ( 29561447 )
2018
14
Variations in vascular anatomy and unilateral adrenal agenesis in a female cadaver with situs inversus totalis. ( 29931532 )
2018
15
Endoscopic submucosal dissection of early gastric cancer via inverted overtube in a patient with situs inversus totalis: a case report. ( 29756022 )
2018
16
A twin study of cilioretinal arteries, tilted discs and situs inversus. ( 29242987 )
2018
17
Brain structural and functional asymmetry in human situs inversus totalis. ( 29302744 )
2018
18
Atypical brain functional segregation is more frequent in situs inversus totalis. ( 29864592 )
2018
19
Laparoscopic sigmoidectomy in a case of sigmoid colon cancer with situs inversus totalis. ( 29601667 )
2018
20
Deranged Myocyte Microstructure in Situs Inversus Totalis Demonstrated by Diffusion Tensor Cardiac Magnetic Resonance. ( 29361490 )
2018
21
Laparoscopic radical nephrectomy for a right renal tumor with renal vein tumor thrombus in a patient with situs inversus totalis. ( 29791972 )
2018
22
Portal vein embolisation in a patient with situs inversus. ( 29348286 )
2018
23
Video-assisted thoracoscopic bisegmentectomies for double primary lung cancers in a patient with situs inversus totalis. ( 29671216 )
2018
24
Trans-aortic pulmonary vein isolation using magnetic navigation system for paroxysmal atrial fibrillation in a patient with dextrocardia, situs inversus, and inferior vena cava continuity with azygos vein. ( 30327707 )
2018
25
Thoraco-Abdominal Abnormalities in Bardet-Biedl Syndrome: Situs Inversus and Heterotaxy. ( 30293640 )
2018
26
Transcatheter aortic valve implantation for severe aortic stenosis in dextrocardia with situs inversus using a self-expanding aortic valve. ( 30279894 )
2018
27
Comparison of Morphologic Findings in Patients with Dextrocardia with Situs Solitus vs Situs Inversus: a Retrospective Study. ( 30334087 )
2018
28
Implantation of a completely right sided subcutaneous cardioverter-defibrillator in a patient with situs inversus dextrocardia. ( 30468861 )
2018
29
Just flip it!-CRT implantation in a patient with dextrocardia and situs inversus totalis. ( 30555613 )
2018
30
Senning Procedure for Transposition of the Great Arteries in a Patient with Situs Inversus Totalis and Dextrocardia. ( 30173681 )
2018
31
Situs Inversus Double Outlet Right Ventricle With Restrictive Interventricular Communication: Role of Transesophageal Echocardiography. ( 30017592 )
2018
32
Laparoscopic One-Anastomosis Gastric Bypass in a Patient with Morbid Obesity and Situs Inversus Totalis: a Case Report. ( 30515621 )
2018
33
Bilateral chylothorax and pericardial effusion following subtotal gastrectomy in a patient with situs inversus totalis. ( 30192067 )
2018
34
Whole-exome sequencing identifies a novel CCDC151 mutation, c.325G>T (p.E109X), in a patient with primary ciliary dyskinesia and situs inversus. ( 30504913 )
2018
35
Pancreatic head cancer involving variant common hepatic artery with situs inversus totalis. ( 26695344 )
2018
36
A case of ventricular septal defect detected after myomectomy by intra-operative transesophageal echocardiography in patient with situs inversus and double-chambered right ventricle. ( 29740751 )
2018
37
"Mirror, Mirror on the Wall"… Pediatric liver transplantation in the case of situs inversus totalis with a disrupted inferior vena cava. ( 29761937 )
2018
38
Laparoscopic cholecystectomy with choledochoduodenostomy in a patient with situs inversus totalis. ( 29882522 )
2018
39
Laparoscopic Sleeve Gastrectomy in Patients with Situs Inversus. ( 29987679 )
2018
40
Situs inversus uniportal video-assisted thoracoscopic right anatomic segmentectomy S1-S2 and S6. ( 29997999 )
2018
41
Laparoscopic Ovarian Cystectomy in a Patient with Situs Inversus Totalis. ( 30026112 )
2018
42
Successful bile duct stone removal by ERCP in a patient with situs inversus. ( 30032926 )
2018
43
Successful pulmonary vein isolation in a patient with situs inversus abdominalis and status post interatrial Dacron patch implantation. ( 30051295 )
2018
44
Gallbladder to the left side of the falciform ligament in absence of Situs Inversus "Sinistroposition" - Case series of 2 patients with this anomaly who underwent mini-laparoscopic cholecystectomy. ( 30077164 )
2018
45
Novel deletion mutation in the glucokinase gene from a korean man with GCK-MODY phenotype and situs inversus. ( 30086370 )
2018
46
Retrolaparoscopic adrenalectomy assisted by three-dimensional reconstructed digital model in a patient with situs inversus totalis. ( 30126414 )
2018
47
Robotic low anterior resection plus transanal natural orifice specimen extraction in a patient with situs inversus totalis. ( 30126461 )
2018
48
Thoracoscopic Lung Lobectomy for a Lung Cancer Patient with Situs Inversus Totalis. ( 30224620 )
2018
49
Using micro computed tomography to investigate a fetal mummy with possible situs inversus: A case report. ( 30286523 )
2018
50
Living donor liver transplantation and situs inversus totalis: cutting the Gordian knot. ( 30317204 )
2018
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Variations for Situs Inversus

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Expression for Situs Inversus

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Search GEO for disease gene expression data for Situs Inversus.
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Pathways for Situs Inversus

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GO Terms for Situs Inversus

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Cellular components related to Situs Inversus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.91 ARL2BP ARMC4 DNAAF1 DNAH11 DNAH5 DNAI1
2 cell projection GO:0042995 9.9 ARL2BP ARMC4 CCDC40 CFAP53 DNAAF1 DNAH11
3 microtubule GO:0005874 9.8 DNAH11 DNAH5 DNAI1 DNAI2 INVS
4 dynein complex GO:0030286 9.62 DNAH11 DNAH5 DNAI1 DNAI2
5 outer dynein arm GO:0036157 9.54 DNAH5 DNAI1 DNAI2
6 axoneme GO:0005930 9.5 ARMC4 CCDC39 CCDC40 DNAAF1 DNAH11 DNAH5
7 axonemal dynein complex GO:0005858 9.46 DNAH5 DNAI2
8 9+2 motile cilium GO:0097729 9.43 DNAH11 DNAH5
9 cilium GO:0005929 9.36 ARL2BP ARMC4 CCDC39 CCDC40 CFAP53 DNAAF1
10 cytoplasm GO:0005737 10.22 ARL2BP ARMC4 CCDC40 DNAAF1 DNAH11 DNAH5

Biological processes related to Situs Inversus according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.95 ARMC4 DNAH11 DNAH5 DNAI1 NODAL
2 cilium assembly GO:0060271 9.88 CFAP53 DNAAF1 DNAH5 DNAI2
3 lung development GO:0030324 9.86 CCDC39 CCDC40 DNAAF1 NODAL
4 microtubule-based movement GO:0007018 9.84 DNAH11 DNAH5 DNAI1 DNAI2
5 heart looping GO:0001947 9.78 CCDC39 CCDC40 DNAAF1 NODAL
6 flagellated sperm motility GO:0030317 9.77 CCDC39 CCDC40 DNAH11 DNAH5 DNAI1
7 cell projection organization GO:0030030 9.76 ARMC4 DNAI1 DNAI2
8 motile cilium assembly GO:0044458 9.74 CCDC39 CCDC40 DNAAF1
9 outer dynein arm assembly GO:0036158 9.72 ARMC4 DNAAF1 DNAH5 DNAI1 DNAI2
10 epithelial cilium movement GO:0003351 9.7 CCDC40 DNAH11 DNAI1
11 determination of left/right symmetry GO:0007368 9.7 ARMC4 CFAP53 DNAH11 DNAH5 DNAI1 DNAI2
12 inner dynein arm assembly GO:0036159 9.69 CCDC39 CCDC40 DNAAF1
13 axonemal dynein complex assembly GO:0070286 9.67 CCDC39 CCDC40 DNAAF1
14 epithelial cilium movement involved in determination of left/right asymmetry GO:0060287 9.65 CCDC39 CCDC40 CFAP53 DNAAF1 DNAH11
15 determination of digestive tract left/right asymmetry GO:0071907 9.63 CCDC39 CCDC40 DNAAF1
16 determination of liver left/right asymmetry GO:0071910 9.61 CCDC39 CCDC40 DNAAF1
17 determination of pancreatic left/right asymmetry GO:0035469 9.58 CCDC39 CCDC40 DNAAF1
18 regulation of cilium beat frequency GO:0003356 9.35 ARMC4 CCDC39 CCDC40 DNAAF1 DNAH11
19 cilium movement GO:0003341 9.28 ARMC4 CCDC39 CCDC40 CFAP53 DNAAF1 DNAH11

Molecular functions related to Situs Inversus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dynein intermediate chain binding GO:0045505 9.43 DNAH11 DNAH5
2 dynein light intermediate chain binding GO:0051959 9.4 DNAH11 DNAH5
3 ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 9.37 DNAI1 DNAI2
4 microtubule motor activity GO:0003777 9.33 DNAH11 DNAH5 DNAI2
5 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 9.32 DNAH11 DNAH5
6 dynein heavy chain binding GO:0045504 9.26 DNAI1 DNAI2
7 motor activity GO:0003774 9.26 DNAH11 DNAH5 DNAI1 DNAI2
8 dynein light chain binding GO:0045503 8.92 DNAH11 DNAH5 DNAI1 DNAI2
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Sources for Situs Inversus

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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