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SIV
MCID: STS002
MIFTS: 50

Situs Inversus (SIV)

Categories: Rare diseases
Genes Variations Tissues Related diseases Publications Drugs
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Aliases & Classifications for Situs Inversus

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MalaCards integrated aliases for Situs Inversus:

Name: Situs Inversus 12 54 30 56 6 45 15
Situs Inversus Viscerum 12 54
Complete Transposition 12
Laterality Sequence 12
Siv 54

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:758
ICD9CM 36 759.3
MeSH 45 D012857
NCIt 51 C87121
SNOMED-CT 69 27317008 43876007
ICD10 34 Q89.3
UMLS 74 C0037221
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Summaries for Situs Inversus

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NIH Rare Diseases : 54 Situs inversus is a condition in which the arrangement of the internal organs is a mirror image of normal anatomy. It can occur alone (isolated, with no other abnormalities or conditions) or it can occur as part of a syndrome with various other defects. Congenital heart defects are present in about 5-10% of affected people. The underlying cause and genetics of situs inversus are complex. Familial cases have been reported.

MalaCards based summary : Situs Inversus, also known as situs inversus viscerum, is related to right atrial isomerism and dextrocardia. An important gene associated with Situs Inversus is DNAH7 (Dynein Axonemal Heavy Chain 7). The drugs Spironolactone and Mineralocorticoids have been mentioned in the context of this disorder. Affiliated tissues include heart, spleen and kidney, and related phenotypes are cardiovascular system and cellular

Wikipedia : 77 Situs inversus (also called situs transversus or oppositus) is a congenital condition in which the major... more...

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Related Diseases for Situs Inversus

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Diseases related to Situs Inversus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 400)
# Related Disease Score Top Affiliating Genes
1 right atrial isomerism 32.6 DNAH5 DNAH7
2 dextrocardia 32.5 CFAP53 DNAI1
3 ciliary dyskinesia, primary, 1 31.9 ARMC4 CCDC103 CCDC40 DNAH5 DNAI1 DNAI2
4 kartagener syndrome 30.9 ARMC4 CCDC103 CCDC39 CCDC40 DNAH11 DNAH5
5 visceral heterotaxy 30.6 ARMC4 CCDC39 CCDC40 CFAP53 DNAH11 DNAH5
6 bronchiectasis 30.5 CCDC40 DNAH5 DNAI1
7 primary ciliary dyskinesia 29.2 ARMC4 CCDC39 DNAH11 DNAH5 DNAI1 DNAI2
8 dextrocardia with situs inversus 12.9
9 retinitis pigmentosa 82 with or without situs inversus 12.6
10 hypoglossia with situs inversus 12.5
11 chondrodysplasia situs inversus imperforate anus polydactyly 12.5
12 aglossia and situs inversus 12.4
13 situs inversus totalis with cystic dysplasia of kidneys and pancreas 12.3
14 jeune syndrome situs inversus 12.3
15 marfanoid habitus with situs inversus 12.2
16 heterotaxy, visceral, 5, autosomal 12.1
17 ciliary dyskinesia, primary, 3 12.1
18 heterotaxy, visceral, 1, x-linked 12.1
19 ciliary dyskinesia, primary, 9 12.1
20 isolated levocardia 12.0
21 ciliary dyskinesia, primary, 5 12.0
22 ciliary dyskinesia, primary, 7 12.0
23 ciliary dyskinesia, primary, 18 12.0
24 ciliary dyskinesia, primary, 23 12.0
25 ciliary dyskinesia, primary, 10 12.0
26 ciliary dyskinesia, primary, 16 12.0
27 ciliary dyskinesia, primary, 17 12.0
28 ciliary dyskinesia, primary, 19 12.0
29 ciliary dyskinesia, primary, 20 12.0
30 ciliary dyskinesia, primary, 25 12.0
31 ciliary dyskinesia, primary, 26 12.0
32 ciliary dyskinesia, primary, 27 12.0
33 ciliary dyskinesia, primary, 28 12.0
34 ciliary dyskinesia, primary, 35 12.0
35 levocardia 12.0
36 ciliary dyskinesia, primary, 2 12.0
37 ciliary dyskinesia, primary, 11 12.0
38 ciliary dyskinesia, primary, 12 12.0
39 ciliary dyskinesia, primary, 13 12.0
40 ciliary dyskinesia, primary, 14 12.0
41 ciliary dyskinesia, primary, 15 12.0
42 ciliary dyskinesia, primary, 21 12.0
43 ciliary dyskinesia, primary, 22 12.0
44 ciliary dyskinesia, primary, 29 12.0
45 ciliary dyskinesia, primary, 30 12.0
46 agnathia-otocephaly complex 12.0
47 ciliary dyskinesia, primary, 36, x-linked 11.9
48 ciliary dyskinesia, primary, 24 11.9
49 ciliary dyskinesia, primary, 37 11.9
50 ciliary dyskinesia, primary, 38 11.9

Graphical network of the top 20 diseases related to Situs Inversus:



Diseases related to Situs Inversus
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Symptoms & Phenotypes for Situs Inversus

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MGI Mouse Phenotypes related to Situs Inversus:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 ARMC4 CCDC39 CFAP53 DNAH11 DNAH5 DNAI1
2 cellular MP:0005384 9.91 ARMC4 CCDC39 CCDC40 DNAH11 DNAH5 DNAI1
3 growth/size/body region MP:0005378 9.9 ARMC4 CCDC39 CCDC40 CFAP53 DNAH11 DNAH5
4 nervous system MP:0003631 9.56 ARMC4 CCDC39 CCDC40 CFAP53 DNAH5 DNAI1
5 respiratory system MP:0005388 9.32 ARMC4 CCDC39 CCDC40 CFAP53 DNAH11 DNAH5
Sources

Drugs & Therapeutics for Situs Inversus

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Drugs for Situs Inversus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
2 Mineralocorticoids Phase 4
3 Hormones Phase 4
4 Natriuretic Agents Phase 4
5 Mineralocorticoid Receptor Antagonists Phase 4
6 Natriuretic Peptide, Brain Phase 4
7 Hormone Antagonists Phase 4
8 diuretics Phase 4
9 Diuretics, Potassium Sparing Phase 4
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
11
Nitric Oxide Approved Phase 3,Not Applicable 10102-43-9 145068
12 Protective Agents Phase 3,Phase 2,Not Applicable
13 Endothelium-Dependent Relaxing Factors Phase 3,Not Applicable
14 Bronchodilator Agents Phase 3,Not Applicable
15 Respiratory System Agents Phase 3,Not Applicable
16 Neurotransmitter Agents Phase 3,Not Applicable
17 Autonomic Agents Phase 3,Not Applicable
18 Anti-Asthmatic Agents Phase 3,Not Applicable
19 Free Radical Scavengers Phase 3,Not Applicable
20 Peripheral Nervous System Agents Phase 3,Not Applicable
21 Antioxidants Phase 3,Not Applicable
22 Vasodilator Agents Phase 3,Phase 2,Not Applicable
23
Ivacaftor Approved Phase 2 873054-44-5 16220172
24
Ambrisentan Approved, Investigational Phase 2 177036-94-1 6918493
25 Simendan Investigational Phase 2 131741-08-7
26 Pharmaceutical Solutions Phase 2
27 Phosphodiesterase Inhibitors Phase 2
28 Phosphodiesterase 3 Inhibitors Phase 2
29 Cardiotonic Agents Phase 2
30 Antihypertensive Agents Phase 2
31
Dobutamine Approved Not Applicable 34368-04-2 36811
32
Mechlorethamine Approved, Investigational 51-75-2 4033
33 Kava Approved, Investigational, Nutraceutical 9000-38-8
34 Liver Extracts
35 3-Iodobenzylguanidine

Interventional clinical trials:

(show top 50) (show all 58)
# Name Status NCT ID Phase Drugs
1 Water Immersion in Right-Sided Heart Failure: A Pilot Study Completed NCT00654264 Phase 4
2 Spironolactone Therapy in Chronic Stable Right HF Trial Recruiting NCT03344159 Phase 4 Spironolactone;Placebo
3 Nitric Oxide During Bypass for Arterial Switch Operation Recruiting NCT03661385 Phase 3 Nitric Oxide
4 Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia Completed NCT02871778 Phase 2 VX-371;Hypertonic Saline;Placebo (0.17% saline);Ivacaftor
5 Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients Recruiting NCT03624010 Phase 2 Levosimendan 2.5 mg/ml Injectable Solution
6 Ambrisentan in Single Ventricle Active, not recruiting NCT02080637 Phase 2 Ambrisentan
7 Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young Adults Unknown status NCT02415491 Not Applicable
8 Early Detection and Characterization of Primary Ciliary Dyskinesia Unknown status NCT01070914
9 Screening for Primary Ciliary Dyskinesia Using Nasal Nitric Oxide Unknown status NCT00739817
10 Comparison of On-line and Off-line Measurements of Exhaled Nitric Oxide (NO) Unknown status NCT00686309
11 Dyskinesia, Heterotaxy and Congenital Heart Disease Completed NCT00608556
12 Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease Completed NCT00368446
13 Late Function After Surgery for Transposition of the Great Arteries Completed NCT03078413
14 MRI Study After Arterial Switch Operation in Patients With Transposition of the Great Arteries Completed NCT01916499
15 Physical Training in Transposition of the Great Arteries Completed NCT00837603 Not Applicable
16 Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart Valves Completed NCT02119442 Not Applicable
17 Respiratory Muscle Strength, Exercise Capacity and Physical Activity Levels in Children Primary Ciliary Dyskinesia Completed NCT03370029
18 Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery Completed NCT02831907
19 Evaluation of Monitoring TECHNOlogies in the PERI-OPerative Care of Cardiac Surgical Patients Completed NCT02658006
20 NIOX VERO Nasal Application in Primary Ciliary Dyskinesia Completed NCT02622061
21 Otolith Function in Patients With Primary Ciliary Dyskinesia Completed NCT01246258
22 Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary Dyskinesia Completed NCT01155115 Not Applicable
23 Diagnosis of Primary Ciliary Dyskinesia Completed NCT00783887
24 Non-invasive Assessment of Liver Stiffness/Fibrosis by Transient Elastography (Fibroscan) in Patients With Left and/or Right Sided Heart Failure Completed NCT00777725
25 Rare Genetic Disorders of the Breathing Airways Completed NCT00323167
26 Genetic Study of Patients With Primary Ciliary Dyskinesia Completed NCT00005650
27 Defining Immunodeficiency in Heterotaxy Syndrome: Pilot Study Data Completed NCT01929967
28 Heterotaxy Syndrome and Intestinal Rotation Abnormalities - A Prospective Study Completed NCT01591928
29 Genetic Analysis of Left-Right Axis Formations Completed NCT00341133
30 Sudden Cardiac in Systemic Right Ventricle Recruiting NCT03833843
31 Acute Maternal Hyperoxygenation for Fetal Transposition of the Great Arteries (TGA) Recruiting NCT03771534 Not Applicable Oxygen gas
32 Fibrosis, Valvular and Ventricular Function in Patients With TGA Recruiting NCT02588989
33 Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters Recruiting NCT03469843
34 Molecular Genetics of Heterotaxy and Related Congenital Heart Defects Recruiting NCT02432079
35 Clinical and Molecular Investigations Into Ciliopathies Recruiting NCT00068224
36 WGS of Korean Idiopathic Bronchiectasis Recruiting NCT03809091
37 PCD New Gene Discovery Recruiting NCT03801395
38 Utility of PCD Diagnostics to Improve Clinical Care Recruiting NCT03704207 Not Applicable
39 Swiss Primary Ciliary Dyskinesia Registry Recruiting NCT03606200
40 International Primary Ciliary Dyskinesia Cohort Recruiting NCT03517865
41 Bacteriological Link Between Upper and Lower Airways in Cystic Fibrosis and Primary Ciliary Dyskinesia Recruiting NCT03494894
42 Multiple Breath Washout, a Clinimetric Dataset Recruiting NCT03320382
43 MRI in Cystic Fibrosis and Primary Ciliary Dyskinesia Recruiting NCT03279965
44 Registry for Primary Ciliary Dyskinesia Recruiting NCT03271840
45 High Resolution Micro OCT Imaging Recruiting NCT03256773
46 International Prospective Patient Registry for Primary Ciliary Dyskinesia (PCD) Recruiting NCT02419365
47 Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease Recruiting NCT00807482
48 Long-term Lung Function and Disease Progression in Children With Early Onset Primary Ciliary Dyskinesia Lung Disease Recruiting NCT00722878
49 Evaluating Progression of and Diagnostic Tools for Primary Ciliary Dyskinesia in Children and Adolescents Recruiting NCT00450918
50 PRospective Observational Multicentre Study on VAriability of Lung Function in Stable PCD Patients Active, not recruiting NCT03704896

Search NIH Clinical Center for Situs Inversus

Cochrane evidence based reviews: situs inversus

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Genetic Tests for Situs Inversus

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Genetic tests related to Situs Inversus:

# Genetic test Affiliating Genes
1 Situs Inversus 30
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Anatomical Context for Situs Inversus

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MalaCards organs/tissues related to Situs Inversus:

42
Heart, Spleen, Kidney, Brain, Colon, Lung, Liver
Sources

Publications for Situs Inversus

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Articles related to Situs Inversus:

(show top 50) (show all 1230)
# Title Authors Year
1
Ventricular assist device in a patient with congenitally corrected transposition of the great arteries and situs inversus totalis. ( 30630389 )
2019
2
Successful Left Ventricular Lead Placement in Congenitally Corrected Transposition of the Great Arteries and Situs Inversus. ( 30898247 )
2019
3
Catheter Ablation of Supraventricular Tachycardia in Patients with Dextrocardia and Situs inversus. ( 30661266 )
2019
4
Situs inversus abdominalis, polysplenia, complex jejunal atresia and malrotation in a neonate: A rare association. ( 30861494 )
2019
5
Primary pulmonary lymphoepithelioma-like carcinoma combined with situs inversus totalis. ( 30614861 )
2019
6
Laparoscopic One-Anastomosis Gastric Bypass in a Patient with Morbid Obesity and Situs Inversus Totalis: a Case Report. ( 30515621 )
2019
7
Whole-exome sequencing identifies a novel CCDC151 mutation, c.325G>T (p.E109X), in a patient with primary ciliary dyskinesia and situs inversus. ( 30504913 )
2019
8
PKD1L1-related situs inversus associated with sideroblastic anemia. ( 30791085 )
2019
9
Duodenoscope combined with laparoscopy in treatment of biliary stones for a patient with situs inversus totalis: A case report. ( 30762727 )
2019
10
Liver Transplant From a Donor With Situs Inversus Totalis Using Orthotopic and Retroversus Technique: A Case Report. ( 30879595 )
2019
11
The First Report of Laparoscopic Pancreaticoduodenectomy for Primary Duodenal Carcinoma in a Patient With Situs Inversus Totalis: Report of a Rare Case. ( 30889057 )
2019
12
Pipeline embolization device implantation in large carotid cavernous aneurysm associated with situs inversus totalis. ( 30895840 )
2019
13
Superficial Spreading-type Gastric Cancer with <i>Situs Inversus Totalis</i>. ( 29695579 )
2018
14
Laparoscopic biliopancreatic diversion for a morbidly obese patient with situs inversus totalis: Case report. ( 29860118 )
2018
15
Robot-assisted distal gastrectomy with lymph node dissection for gastric cancer in a patient with situs inversus partialis: a case report with video file. ( 29441475 )
2018
16
Laparoscopic colon resection in patients with situs inversus totalis: Is it the same operation as in patients without situs inversus totalis? ( 29737309 )
2018
17
Laparoscopic Roux-en-Y gastric bypass in a patient with situs inversus totalis: Case report, technical tips and review of the literature. ( 29573597 )
2018
18
Case report about a successful full robotic radical gastric cancer surgery with intracorporeal robot-sewn anastomosis in a patient with situs inversus totalis and a two-and-a-half-year follow-up study. ( 29499701 )
2018
19
Thoracoscopic total esophagogastrectomy with supercharged colon interposition for the treatment of esophageal adenocarcinoma in situs inversus. ( 29436979 )
2018
20
Transcatheter Aortic Valve Replacement in a Patient with Dextrocardia and Situs Inversus Totalis. ( 29908190 )
2018
21
Gastric cancer with situs inversus totalis: does it really create difficulties for surgeons? ( 29657611 )
2018
22
Incidental adult polysplenia with situs inversus, interrupted inferior vena cava with azygos continuation, patent ductus arteriosus, and aortic branches variations: a case report. ( 29607204 )
2018
23
Successful ERCP for management of traumatic pancreatic disruption in a patient with situs inversus. ( 29552451 )
2018
24
Situs Inversus Totalis and Cholangiocarcinoma of the Gallbladder Detected by 18F-FDG PET/CT. ( 29538026 )
2018
25
Situs inversus totalis with solid pseudopapillary pancreatic tumor: A case report and review of literature. ( 29561447 )
2018
26
Variations in vascular anatomy and unilateral adrenal agenesis in a female cadaver with situs inversus totalis. ( 29931532 )
2018
27
Endoscopic submucosal dissection of early gastric cancer via inverted overtube in a patient with situs inversus totalis: a case report. ( 29756022 )
2018
28
A twin study of cilioretinal arteries, tilted discs and situs inversus. ( 29242987 )
2018
29
Brain structural and functional asymmetry in human situs inversus totalis. ( 29302744 )
2018
30
Atypical brain functional segregation is more frequent in situs inversus totalis. ( 29864592 )
2018
31
Laparoscopic sigmoidectomy in a case of sigmoid colon cancer with situs inversus totalis. ( 29601667 )
2018
32
Deranged Myocyte Microstructure in Situs Inversus Totalis Demonstrated by Diffusion Tensor Cardiac Magnetic Resonance. ( 29361490 )
2018
33
Laparoscopic radical nephrectomy for a right renal tumor with renal vein tumor thrombus in a patient with situs inversus totalis. ( 29791972 )
2018
34
Portal vein embolisation in a patient with situs inversus. ( 29348286 )
2018
35
Video-assisted thoracoscopic bisegmentectomies for double primary lung cancers in a patient with situs inversus totalis. ( 29671216 )
2018
36
A case of ventricular septal defect detected after myomectomy by intra-operative transesophageal echocardiography in patient with situs inversus and double-chambered right ventricle. ( 29740751 )
2018
37
Laparoscopic cholecystectomy with choledochoduodenostomy in a patient with situs inversus totalis. ( 29882522 )
2018
38
Trans-aortic pulmonary vein isolation using magnetic navigation system for paroxysmal atrial fibrillation in a patient with dextrocardia, situs inversus, and inferior vena cava continuity with azygos vein. ( 30327707 )
2018
39
Thoraco-Abdominal Abnormalities in Bardet-Biedl Syndrome: Situs Inversus and Heterotaxy. ( 30293640 )
2018
40
Senning Procedure for Transposition of the Great Arteries in a Patient with Situs Inversus Totalis and Dextrocardia. ( 30173681 )
2018
41
Transcatheter aortic valve implantation for severe aortic stenosis in dextrocardia with situs inversus using a self-expanding aortic valve. ( 30279894 )
2018
42
Comparison of Morphologic Findings in Patients with Dextrocardia with Situs Solitus vs Situs Inversus: a Retrospective Study. ( 30334087 )
2018
43
Implantation of a completely right sided subcutaneous cardioverter-defibrillator in a patient with situs inversus dextrocardia. ( 30468861 )
2018
44
Just flip it!-CRT implantation in a patient with dextrocardia and situs inversus totalis. ( 30555613 )
2018
45
Rare case of septum primum malposition defect in dextrocardia and situs inversus totalis without heterotaxy syndrome. ( 30585568 )
2018
46
Situs Inversus Double Outlet Right Ventricle With Restrictive Interventricular Communication: Role of Transesophageal Echocardiography. ( 30017592 )
2018
47
Bilateral chylothorax and pericardial effusion following subtotal gastrectomy in a patient with situs inversus totalis. ( 30192067 )
2018
48
"Mirror, Mirror on the Wall"… Pediatric liver transplantation in the case of situs inversus totalis with a disrupted inferior vena cava. ( 29761937 )
2018
49
Laparoscopic Sleeve Gastrectomy in Patients with Situs Inversus. ( 29987679 )
2018
50
Situs inversus uniportal video-assisted thoracoscopic right anatomic segmentectomy S1-S2 and S6. ( 29997999 )
2018
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Variations for Situs Inversus

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ClinVar genetic disease variations for Situs Inversus:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DNAH7 NM_018897.3(DNAH7): c.8209G> A (p.Gly2737Ser) single nucleotide variant Pathogenic GRCh38 Chromosome 2, 195857582: 195857582
2 DNAH7 NM_018897.3(DNAH7): c.8209G> A (p.Gly2737Ser) single nucleotide variant Pathogenic GRCh37 Chromosome 2, 196722306: 196722306
3 DNAH7 NM_018897.3(DNAH7): c.11947C> T (p.Arg3983Trp) single nucleotide variant Pathogenic GRCh38 Chromosome 2, 195738049: 195738049
4 DNAH7 NM_018897.3(DNAH7): c.11947C> T (p.Arg3983Trp) single nucleotide variant Pathogenic GRCh37 Chromosome 2, 196602773: 196602773
Sources

Expression for Situs Inversus

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Search GEO for disease gene expression data for Situs Inversus.
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Pathways for Situs Inversus

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GO Terms for Situs Inversus

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Cellular components related to Situs Inversus according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 microtubule GO:0005874 9.88 DNAH11 DNAH5 DNAH7 DNAI1 DNAI2 INVS
2 cell projection GO:0042995 9.77 ARL2BP ARMC4 CCDC103 CCDC40 CFAP53 DNAH11
3 motile cilium GO:0031514 9.76 CCDC103 CCDC40 DNAH11 RSPH4A
4 axoneme GO:0005930 9.76 ARMC4 CCDC103 CCDC39 CCDC40 DNAH11 DNAH5
5 dynein complex GO:0030286 9.65 DNAH11 DNAH5 DNAH7 DNAI1 DNAI2
6 axonemal dynein complex GO:0005858 9.61 DNAH5 DNAH7 DNAI2
7 outer dynein arm GO:0036157 9.54 DNAH5 DNAI1 DNAI2
8 9+2 motile cilium GO:0097729 9.49 DNAH11 DNAH5
9 cilium GO:0005929 9.44 ARL2BP ARMC4 CCDC103 CCDC39 CCDC40 CFAP53
10 cytoplasm GO:0005737 10.29 ARL2BP ARMC4 CCDC103 CCDC40 DNAH11 DNAH5
11 cytoskeleton GO:0005856 10.02 ARL2BP ARMC4 DNAH11 DNAH5 DNAH7 DNAI1

Biological processes related to Situs Inversus according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 microtubule-based movement GO:0007018 9.83 DNAH11 DNAH5 DNAH7 DNAI1 DNAI2
2 cell projection organization GO:0030030 9.81 ARMC4 CCDC103 DNAI1 DNAI2
3 flagellated sperm motility GO:0030317 9.8 CCDC39 CCDC40 DNAH11 DNAH5 DNAI1
4 cilium assembly GO:0060271 9.77 CFAP53 DNAH5 DNAI2
5 heart development GO:0007507 9.73 DNAH11 DNAH5 DNAI1
6 determination of left/right symmetry GO:0007368 9.73 ARMC4 CFAP53 DNAH11 DNAH5 DNAI1 DNAI2
7 heart looping GO:0001947 9.7 CCDC103 CCDC39 CCDC40
8 epithelial cilium movement GO:0003351 9.67 CCDC40 DNAH11 DNAI1
9 inner dynein arm assembly GO:0036159 9.67 CCDC103 CCDC39 CCDC40 DNAH7
10 axonemal dynein complex assembly GO:0070286 9.65 CCDC103 CCDC39 CCDC40
11 determination of digestive tract left/right asymmetry GO:0071907 9.63 CCDC103 CCDC39 CCDC40
12 regulation of cilium beat frequency GO:0003356 9.62 ARMC4 CCDC39 CCDC40 DNAH11
13 motile cilium assembly GO:0044458 9.58 CCDC39 CCDC40
14 axoneme assembly GO:0035082 9.58 CCDC40 RSPH4A
15 cilium-dependent cell motility GO:0060285 9.57 CCDC39 DNAH7
16 determination of liver left/right asymmetry GO:0071910 9.55 CCDC39 CCDC40
17 outer dynein arm assembly GO:0036158 9.55 ARMC4 CCDC103 DNAH5 DNAI1 DNAI2
18 determination of pancreatic left/right asymmetry GO:0035469 9.54 CCDC39 CCDC40
19 cilium movement GO:0003341 9.36 ARMC4 CCDC103 CCDC39 CCDC40 CFAP53 DNAH11
20 epithelial cilium movement involved in determination of left/right asymmetry GO:0060287 9.35 CCDC103 CCDC39 CCDC40 CFAP53 DNAH11

Molecular functions related to Situs Inversus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dynein intermediate chain binding GO:0045505 9.54 DNAH11 DNAH5 DNAH7
2 dynein light intermediate chain binding GO:0051959 9.5 DNAH11 DNAH5 DNAH7
3 microtubule motor activity GO:0003777 9.46 DNAH11 DNAH5 DNAH7 DNAI2
4 ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 9.43 DNAI1 DNAI2
5 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 9.43 DNAH11 DNAH5 DNAH7
6 dynein heavy chain binding GO:0045504 9.4 DNAI1 DNAI2
7 motor activity GO:0003774 9.35 DNAH11 DNAH5 DNAH7 DNAI1 DNAI2
8 dynein light chain binding GO:0045503 9.02 DNAH11 DNAH5 DNAH7 DNAI1 DNAI2
Sources

Sources for Situs Inversus

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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