Situs Inversus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ Situs inversus is a condition in which the arrangement of the internal organs is a mirror image of normal anatomy. It can occur alone (isolated, with no other abnormalities or conditions) or it can occur as part of a syndrome with various other defects. Congenital heart defects are present in about 5-10% of affected people. The underlying cause and genetics of Situs inversus are complex. Familial cases have been reported.

MalaCards based summary: Situs Inversus, also known as situs inversus viscerum, is related to dextrocardia with situs inversus and ciliary dyskinesia, primary, 1. An important gene associated with Situs Inversus is CFAP53 (Cilia And Flagella Associated Protein 53), and among its related pathways/superpathways are Ciliopathies and Signaling by NODAL. The drugs Nitric Oxide and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related phenotypes are growth/size/body region and nervous system

Disease Ontology: ¹¹ A visceral heterotaxy that is characterized by complete right-to-left reversal of the position of the major thoracic and abdominal organs.

Wikipedia: ⁷⁵ Situs inversus (also called situs transversus or oppositus) is a congenital condition in which the major... more...

Sources

Related Diseases for Situs Inversus

Diseases related to Situs Inversus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 864)

#	Related Disease	Score	Top Affiliating Genes
1	dextrocardia with situs inversus	33.8	PKD1L1 MNS1 DNAH11 CFAP53 CCDC103
2	ciliary dyskinesia, primary, 1	33.5	DNAI1 DNAH5 DNAH11 CCDC40 CCDC103
3	visceral heterotaxy	33.4	PKD1L1 ODAD4 MNS1 INVS GDF1 DNAI1
4	ciliary dyskinesia, primary, 3	33.4	DNAH5 DNAH11
5	dextrocardia	33.2	DNAI1 DNAH5 DNAH11 DNAAF11 CFAP53 CCDC40
6	primary ciliary dyskinesia	33.2	PKD1L1 ODAD4 MNS1 INVS GDF1 DNAI1
7	ciliary dyskinesia, primary, 30	33.2	DNAH5 CCDC40 CCDC39
8	ciliary dyskinesia, primary, 14	33.1	CCDC40 CCDC39
9	ciliary dyskinesia, primary, 4	33.1	DNAI1 DNAH5 DNAH11 CCDC40 CCDC39 CCDC103
10	ciliary dyskinesia, primary, 2	33.0	DNAAF11 DNAAF1
11	ciliary dyskinesia, primary, 26	33.0	CFAP298-TCP10L CFAP298
12	ciliary dyskinesia, primary, 7	32.9	DNAH5 DNAH11
13	right atrial isomerism	32.9	INVS GDF1 DNAI1 DNAH5 DNAH11 DAND5
14	kartagener syndrome	32.8	ODAD4 DNAI1 DNAH7 DNAH5 DNAH11 DNAAF11
15	ciliary dyskinesia, primary, 8	32.7	DNAI1 DNAH5 DNAH11 CCDC40 CCDC39 CCDC103
16	transposition of the great arteries, dextro-looped	32.0	PKD1L1 GDF1 DNAI1 DNAH5 CERS1
17	bronchiectasis	31.9	DNAI1 DNAH5 DNAH11 DNAAF11 DNAAF1 CCDC40
18	double outlet right ventricle	31.4	GDF1 DNAH5 CERS1
19	retinitis pigmentosa	31.0	INVS DNAI1 DNAH5 DNAH11 DNAAF1 CFAP298
20	chronic rhinitis	30.9	DNAH5 DNAH11 CCDC40
21	polycystic kidney disease 2 with or without polycystic liver disease	30.8	PKD1L1 MNS1 DAND5
22	retinitis pigmentosa 82 with or without situs inversus	11.7
23	agnathia-otocephaly complex	11.7
24	ciliary dyskinesia, primary, 28	11.7
25	ciliary dyskinesia, primary, 5	11.7
26	ciliary dyskinesia, primary, 9	11.7
27	ciliary dyskinesia, primary, 18	11.7
28	ciliary dyskinesia, primary, 23	11.7
29	ciliary dyskinesia, primary, 20	11.7
30	ciliary dyskinesia, primary, 40	11.7
31	ciliary dyskinesia, primary, 10	11.7
32	ciliary dyskinesia, primary, 16	11.7
33	ciliary dyskinesia, primary, 17	11.7
34	ciliary dyskinesia, primary, 19	11.7
35	ciliary dyskinesia, primary, 25	11.7
36	ciliary dyskinesia, primary, 27	11.7
37	isolated levocardia	11.7
38	ciliary dyskinesia, primary, 35	11.7
39	ciliary dyskinesia, primary, 29	11.6
40	ciliary dyskinesia, primary, 11	11.6
41	ciliary dyskinesia, primary, 12	11.6
42	ciliary dyskinesia, primary, 13	11.6
43	ciliary dyskinesia, primary, 15	11.6
44	ciliary dyskinesia, primary, 21	11.6
45	ciliary dyskinesia, primary, 22	11.6
46	ciliary dyskinesia, primary, 38	11.6
47	ciliary dyskinesia, primary, 39	11.6
48	ciliary dyskinesia, primary, 43	11.6
49	ciliary dyskinesia, primary, 44	11.6
50	heterotaxy, visceral, 5, autosomal	11.6

Graphical network of the top 20 diseases related to Situs Inversus:

Sources

Symptoms & Phenotypes for Situs Inversus

MGI Mouse Phenotypes related to Situs Inversus:

⁴⁵ (show all 11)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.28	CCDC39 CCDC40 CERS1 CFAP53 DAND5 DNAAF11
2	nervous system	MP:0003631	10.27	CCDC39 CCDC40 CERS1 CFAP53 DNAAF1 DNAAF11
3	embryo	MP:0005380	10.06	CCDC40 CFAP53 DAND5 DNAAF11 DNAH11 GDF1
4	cellular	MP:0005384	10.03	CCDC39 CCDC40 CERS1 CFAP53 DNAAF11 DNAH11
5	renal/urinary system	MP:0005367	10.02	CCDC39 CCDC40 DNAH11 DNAH5 GDF1 INVS
6	liver/biliary system	MP:0005370	10	CCDC39 CFAP53 DNAAF11 DNAH11 DNAH5 GDF1
7	cardiovascular system	MP:0005385	9.93	CCDC39 CFAP53 DAND5 DNAAF1 DNAAF11 DNAH11
8	digestive/alimentary	MP:0005381	9.91	CCDC39 DNAAF11 DNAH11 DNAH5 GDF1 INVS
9	craniofacial	MP:0005382	9.87	CCDC39 DNAAF1 DNAAF11 DNAH11 DNAH5 DNAI1
10	respiratory system	MP:0005388	9.77	CCDC39 CCDC40 CFAP53 DAND5 DNAAF11 DNAH11
11	mortality/aging	MP:0010768	9.5	CCDC39 CCDC40 CERS1 CFAP53 DAND5 DNAAF1

Sources

Drugs & Therapeutics for Situs Inversus

Drugs for Situs Inversus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Nitric Oxide

Approved

Phase 3

10102-43-9

145068

2

Neurotransmitter Agents

Phase 3

3

Bronchodilator Agents

Phase 3

4

Endothelium-Dependent Relaxing Factors

Phase 3

5

Anti-Asthmatic Agents

Phase 3

6

Vasodilator Agents

Phase 3

7

Respiratory System Agents

Phase 3

8

Antioxidants

Phase 3

9

Protective Agents

Phase 3

10

Mechlorethamine

Approved, Investigational

51-75-2

4033

11

Pharmaceutical Solutions

12

3-Iodobenzylguanidine

Interventional clinical trials:

(show all 12)

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomised Controlled Trial of Nitric Oxide Administration During Cardiopulmonary Bypass in Infants Undergoing Arterial Switch Operation for Repair of Transposition of the Great Arteries	Unknown status	NCT03661385	Phase 3	Nitric Oxide
2	A Retrospective Comparison of the Efficacy and Safety of Celsior® in Pediatric Cardiac Surgery for Transposition of the Great Vessels	Unknown status	NCT04616222		CELSIOR® group;Saint-Thomas group
3	Ciliary Dysfunction as an Underlying Etiology Linking Primary Ciliary Dyskinesia With Heterotaxy and Complex Congenital Heart Disease	Completed	NCT00608556
4	MRI Study After Arterial Switch Operation in Patients With Transposition of the Great Arteries	Completed	NCT01916499
5	Late Function After Surgery for Transposition of the Great Arteries	Completed	NCT03078413
6	Influence of Timing of Switch Operation in Transposition of Great Arteries	Completed	NCT05160116
7	Outcomes of Transposition of the Great Arteries After Arterial Switch Operation: a Dual-center Study	Completed	NCT05089773
8	Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters	Completed	NCT03469843
9	Transposition of the Great Arteries: Prenatal Anatomical and Hemodynamic Findings Associated With Perinatal Outcomes	Recruiting	NCT03771534		Oxygen gas
10	Measurement of the Prevalence of Sensory Integration Disorders in Babies Having Heart Disease Surgery for Transposition of the Great Vessels Before 6 Months of Age	Recruiting	NCT05137873
11	Cardiac Resynchronization Therapy in Adult Congenital Heart Disease With Systemic Right Ventricle: A Cross-Over Trial	Not yet recruiting	NCT05524324
12	Clinical Impact of Rapid Prototyping 3D Models of Congenital Heart Disease on Surgical Management	Withdrawn	NCT04788082

Search NIH Clinical Center for Situs Inversus

Cochrane evidence based reviews: situs inversus

Sources

Genetic Tests for Situs Inversus

Genetic tests related to Situs Inversus:

#	Genetic test	Affiliating Genes
1	Situs Inversus ²⁸

Sources

Anatomical Context for Situs Inversus

Organs/tissues related to Situs Inversus:

MalaCards : Heart, Liver, Lung, Spleen, Colon, Atrioventricular Node, Kidney

Sources

Publications for Situs Inversus

Articles related to Situs Inversus:

(show top 50) (show all 3792)

#	Title	Authors	PMID	Year
1	Bi-allelic Mutations in PKD1L1 Are Associated with Laterality Defects in Humans. ⁶² ⁵	Vetrini F...Yang Y	27616478	2016
2	Association of INVS (NPHP2) mutation in an adolescent exhibiting nephronophthisis (NPH) and complete situs inversus. ⁵³ ⁶²	Okada M...Takemura T	18218308	2008
3	Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. ⁵³ ⁶²	Otto EA...Hildebrandt F	12872123	2003
4	Cardiopulmonary malformations in the inv/inv mouse. ⁵³ ⁶²	McQuinn TC...Wessels A	11331972	2001
5	Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome). ⁵³ ⁶²	Guichard C...Bouvagnet P	11231901	2001
6	Endoscopic ultrasound-guided bile duct reconstruction after complete section following a car crash in a 5-year-old child with complete situs inversus. ⁶²	Yzet C...Pioche M	36460043	2022
7	LOF variants identifying candidate genes of laterality defects patients with congenital heart disease. ⁶²	Liu S...Xu R	36459505	2022
8	A rare case report of situs inversus totalis underwent coronary artery bypass grafting. ⁶²	Kong L...Duan G	36428136	2022
9	Correction to "Laparoscopy-assisted resection of colorectal cancer with situs inversus totalis: A case report and literature review". ⁶²	Chen W...Huang MJ	36438883	2022
10	Efficacy and safety of ERCP in patients with situs inversus totalis: multicenter case series and literature review. ⁶²	Ding B...Wang X	36451092	2022
11	Common trunk anomaly of the anterior and posterior inferior cerebellar artery in hemifacial spasm. ⁶²	Goto Y...Inoue T	35524812	2022
12	Successful management of ectopic kidney stones in a patient with situs inversus totalis: a rare case report. ⁶²	Mansour M...Alrebdawi K	36357922	2022
13	[Sinusitis, otitis media and diffuse bronchiectasis in both lungs]. ⁶²	Zhou WJ...Tian XL	36344229	2022
14	Transpositions of the great arteries versus aortic dextropositions. A review of some embryogenetic and morphological aspects. ⁶²	Restivo A...Putotto C	36426596	2022
15	Laterality Defects in Primary Ciliary Dyskinesia: Relationship to Ultrastructural Defect or Genotype. ⁶²	Barber AT...Genetic Disorders of Mucociliary Clearance Consortium (GDMCC)	36342963	2022
16	Rethinking the cilia hypothesis of hydrocephalus. ⁶²	Duy PQ...Kahle KT	36341771	2022
17	Progress in diagnosis of primary ciliary dyskinesia. ⁶²	Wei S...Cheng Y	36069395	2022
18	Surgical challenges during open pancreaticoduodenectomy in a patient with situs inversus totalis: A rare case report and literature review. ⁶²	Jomaa S...Alahmar FO	36268427	2022
19	A novel nonsense PKD1L1 variant cause heterotaxy syndrome with congenital asplenia in a Han Chinese patient. ⁶²	Gu H...Tan ZP	35691949	2022
20	Ascending colon cancer and situs inversus totalis - altered surgeon position for successful laparoscopic hemicolectomy: A case report. ⁶²	Hu JL...Wu K	36337311	2022
21	A rare cause of syncope in patients with situs inversus totalis and corrected transposition of the great arteries: Very late lead perforation. ⁶²	Kus G...Arslan S	35583744	2022
22	Challenges of emergency enbloc laparoscopic proximal hemicolectomy and cholecystectomy in situs inversus totalis. ⁶²	Teoh MMK...Coveney A	35441785	2022
23	Laparoscopic cholecystectomy in a patient with situs inversus totalis. ⁶²	Montalvo-Jave EE...Rodriguez-Baez A	36243675	2022
24	ERCP and EUS technique in situs inversus totalis: preparing for a left-sided plot twist. ⁶²	Naser J...Chahal P	36238805	2022
25	Robotic distal gastrectomy for gastric cancer in a patient with situs inversus totalis and a vascular anomaly. ⁶²	Sagawa H...Takiguchi S	36186219	2022
26	Laparoscopic distal gastrectomy for gastric cancer in a patient with situs inversus: a case report. ⁶²	Sato K...Sugita M	36205851	2022
27	"Reverse life": A rare case report of situs inversus totalis combined with cardiac abnormalities in a young stroke. ⁶²	Chen XQ...Guo ZK	35702947	2022
28	Robotic-assisted pulmonary lobectomy with lung cancer in a patient with situs inversus totalis. ⁶²	Yang C...Wang Q	36050769	2022
29	Laparoscopic distal gastrectomy for advanced gastric cancer with situs inversus totalis: a case report. ⁶²	Fujita S...Inomata M	36163524	2022
30	Redo aortic valve surgery in a case of dextrocardia with situs inversus totalis. ⁶²	Dinato FJ...Jatene FB	36027831	2022
31	Sinistroposition: A case report on incidental finding of left sided gall bladder on laparoscopic cholecystectomy. ⁶²	Malla S...Rawal SB	36147104	2022
32	Rare presentation of central retinal vein occlusion sparing the superotemporal quadrant in a patient with congenital cardiovascular disease. ⁶²	Anzidei R...Konidaris VE	36127035	2022
33	AMBRA1 p.Gln30Arg Mutation, Identified in a Cowden Syndrome Family, Exhibits Hyperproliferative Potential in hTERT-RPE1 Cells. ⁶²	Revathidevi S...Inoue I	36232425	2022
34	Transapical transcatheter J-valve for aortic regurgitation in dextrocardia situs inversus. ⁶²	Chan DT...Au TW	35234054	2022
35	Left Bundle Area Pacing for Tachycardia-Bradycardia Syndrome in a Patient With Dextrocardia. ⁶²	Bodagh N...Wong T	36213881	2022
36	Type II congenital pulmonary airway malformation with primary ciliary dyskinesia in a 4-year-old child: A case report. ⁶²	Li L...Wang W	36165169	2022
37	Primary Ciliary Dyskinesia: Phenotype Resulting From a Novel Variant of LRRC56 Gene. ⁶²	Alasmari BG...Tahir AM	36176820	2022
38	Biallelic DNAH9 mutations are identified in Chinese patients with defective left-right patterning and cilia-related complex congenital heart disease. ⁶²	Chen W...Zhou X	35050399	2022
39	Pancreatoduodenectomy with portal vein resection for pancreatic body cancer in a patient with situs inversus totalis. ⁶²	Nagai K...Hatano E	35839563	2022
40	Exome sequencing in individuals with cardiovascular laterality defects identifies potential candidate genes. ⁶²	Breuer K...Hoefele J	35474353	2022
41	Infantile hypertrophic pyloric stenosis, the cause of non-bilious vomiting of a 3-day-old male infant with situs inversus totalis: A case report. ⁶²	Samady Khanghah A...Tabatabaey A	35957763	2022
42	A Case of Unusual Presentation of Kartagener's Syndrome in a 22-Year-Old Female Patient. ⁶²	Sahu S...Manjunath H	36134054	2022
43	Thoracoscopic AF ablation in situs inversus dextrocardia with interrupted inferior vena cava continuation in azygos vein. ⁶²	Fabrizio R...Stefano B	35637597	2022
44	Looking in a mirror, laparoscopic gastric sleeve in situs inversus patient: a case report. ⁶²	Paipilla OA...Diaz MA	35865255	2022
45	Sleeve gastrectomy in a patient with situs inversus: a case report. ⁶²	Alonazi I...Alghamdi G	35919692	2022
46	Laparoscopic sleeve gastrectomy in a patient with Situs Inversus Totalis: A case report and literature review. ⁶²	Amirbeigi A...Elyasinia F	35860141	2022
47	Laparoscopic Roux-en-Y gastric bypass in a patient with situs inversus totalis: case report. ⁶²	Zorrilla-Blanco PG...de la O-Escamilla M	35892124	2022
48	Da Vinci robot-assisted pancreato-duodenectomy in a patient with situs inversus totalis: A case report and review of literature. ⁶²	Li BB...Yu SP	36051094	2022
49	Left sided Amyand hernia - A case report. ⁶²	Joshi J...Varghese GM	35797875	2022
50	Laparoscopic Colectomy for a Patient with Situs Inversus Totalis: The Usefulness of Preoperative Assessment. ⁶²	Sakamoto J...Fujita S	35869611	2022

Sources

Genes for Situs Inversus

Genes related to Situs Inversus (14 elite genes):

(show top 50) (show all 124)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CFAP53	Cilia And Flagella Associated Protein 53	Protein Coding	449.48	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
2	PKD1L1	Polycystin 1 Like 1, Transient Receptor Potential Channel Interacting	Protein Coding	432.25	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴	27616478
3	DNAH5	Dynein Axonemal Heavy Chain 5	Protein Coding	426.17	Pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
4	ODAD4	Outer Dynein Arm Docking Complex Subunit 4	Protein Coding	424.01	Pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Summaries (show sections)
5	CCDC40	Coiled-Coil Domain Containing 40	Protein Coding	416.51	Pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
6	CCDC103	Coiled-Coil Domain Containing 103	Protein Coding	415.9	Pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
7	DNAAF11	Dynein Axonemal Assembly Factor 11	Protein Coding	415.23	Pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
8	DNAAF1	Dynein Axonemal Assembly Factor 1	Protein Coding	415.15	Pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
9	CFAP298	Cilia And Flagella Associated Protein 298	Protein Coding	414.35	Pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
10	GDF1	Growth Differentiation Factor 1	Protein Coding	413.82	Pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
11	CFAP300	Cilia And Flagella Associated Protein 300	Protein Coding	413.38	Pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
12	DNAH7	Dynein Axonemal Heavy Chain 7	Protein Coding	405.88	Pathogenic ⁵ DISEASES inferred ¹⁴
13	CERS1	Ceramide Synthase 1	Protein Coding	405.15	Pathogenic ⁵ DISEASES inferred ¹⁴
14	CFAP298-TCP10L	CFAP298-TCP10L Readthrough	Protein Coding	400	Pathogenic ⁵
15	DNAH11	Dynein Axonemal Heavy Chain 11	Protein Coding	61.51	Likely pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
16	CCDC39	Coiled-Coil Domain Containing 39	Protein Coding	41.18	Likely pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
17	MNS1	Meiosis Specific Nuclear Structural 1	Protein Coding	39.71	Likely pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
18	DNAI1	Dynein Axonemal Intermediate Chain 1	Protein Coding	36.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	11231901
19	INVS	Inversin	Protein Coding	36.64	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	12872123 18218308 11331972
20	DAND5	DAN Domain BMP Antagonist Family Member 5	Protein Coding	31.53	Likely pathogenic ⁵ DISEASES inferred ¹⁴
21	CDCA7L	Cell Division Cycle Associated 7 Like	Protein Coding	28.2	Likely pathogenic ⁵ DISEASES inferred ¹⁴
22	DNAH9	Dynein Axonemal Heavy Chain 9	Protein Coding	25.09	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
23	BRWD1	Bromodomain And WD Repeat Domain Containing 1	Protein Coding	25	Likely pathogenic ⁵
24	TEX9	Testis Expressed 9	Protein Coding	25	Likely pathogenic ⁵
25	ODAD3	Outer Dynein Arm Docking Complex Subunit 3	Protein Coding	24.32	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
26	LZTFL1	Leucine Zipper Transcription Factor Like 1	Protein Coding	22.69	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
27	DNAAF3	Dynein Axonemal Assembly Factor 3	Protein Coding	15.96	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
28	DNAI2	Dynein Axonemal Intermediate Chain 2	Protein Coding	15.92	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
29	ZIC3	Zic Family Member 3	Protein Coding	15.91	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
30	NPHP3	Nephrocystin 3	Protein Coding	15.81	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
31	HYDIN	HYDIN Axonemal Central Pair Apparatus Protein	Protein Coding	15.77	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
32	RSPH9	Radial Spoke Head Component 9	Protein Coding	15.44	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
33	DNAAF2	Dynein Axonemal Assembly Factor 2	Protein Coding	15.42	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
34	RSPH4A	Radial Spoke Head Component 4A	Protein Coding	15.41	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
35	ODAD1	Outer Dynein Arm Docking Complex Subunit 1	Protein Coding	15.23	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
36	RSPH1	Radial Spoke Head Component 1	Protein Coding	15.2	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
37	DNAAF4	Dynein Axonemal Assembly Factor 4	Protein Coding	15.07	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
38	NPHP1	Nephrocystin 1	Protein Coding	15.05	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
39	ODAD2	Outer Dynein Arm Docking Complex Subunit 2	Protein Coding	15.02	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
40	DRC1	Dynein Regulatory Complex Subunit 1	Protein Coding	14.97	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
41	NODAL	Nodal Growth Differentiation Factor	Protein Coding	14.96	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
42	NME8	NME/NM23 Family Member 8	Protein Coding	14.83	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
43	CCDC65	Coiled-Coil Domain Containing 65	Protein Coding	14.82	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
44	DNAAF5	Dynein Axonemal Assembly Factor 5	Protein Coding	14.72	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
45	DNAAF6	Dynein Axonemal Assembly Factor 6	Protein Coding	14.69	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
46	DNAH1	Dynein Axonemal Heavy Chain 1	Protein Coding	14.55	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
47	ZMYND10	Zinc Finger MYND-Type Containing 10	Protein Coding	14.53	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
48	NME7	NME/NM23 Family Member 7	Protein Coding	14.44	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
49	SPAG1	Sperm Associated Antigen 1	Protein Coding	14.44	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
50	CCNO	Cyclin O	Protein Coding	14.37	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)

Sources

Variations for Situs Inversus

ClinVar genetic disease variations for Situs Inversus:

⁵ (show top 50) (show all 81)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	DNAH5	NM_001369.3(DNAH5):c.11725C>T (p.Arg3909Ter)	SNV	Pathogenic	407242	rs1060501464	GRCh37: 5:13735276-13735276 GRCh38: 5:13735167-13735167
2	CERS1, GDF1	NM_001492.6(GDF1):c.608G>A (p.Trp203Ter)	SNV	Pathogenic	985628	rs1359321518	GRCh37: 19:18979917-18979917 GRCh38: 19:18869108-18869108
3	CFAP53	NM_145020.5(CFAP53):c.778-2A>T	SNV	Pathogenic	1065350		GRCh37: 18:47777348-47777348 GRCh38: 18:50250978-50250978
4	CFAP300	NM_032930.3(CFAP300):c.693_694insGA (p.Tyr232fs)	INSERT	Pathogenic	1065351		GRCh37: 11:101953819-101953820 GRCh38: 11:102083088-102083089
5	CCDC40	NM_017950.4(CCDC40):c.2832+489_2832+491dup	DUP	Pathogenic	1065352		GRCh37: 17:78064171-78064172 GRCh38: 17:80090372-80090373
6	ODAD4	NM_031421.5(ODAD4):c.1979del (p.Thr660fs)	DEL	Pathogenic	1065353		GRCh37: 17:40117461-40117461 GRCh38: 17:41965443-41965443
7	CFAP298-TCP10L, CFAP298	NM_021254.4(CFAP298):c.308C>A (p.Ala103Asp)	SNV	Pathogenic	1065354		GRCh37: 21:33980026-33980026 GRCh38: 21:32607716-32607716
8	DNAH7	NM_018897.3(DNAH7):c.8209G>A (p.Gly2737Ser)	SNV	Pathogenic	599649	rs770861172	GRCh37: 2:196722306-196722306 GRCh38: 2:195857582-195857582
9	DNAH7	NM_018897.3(DNAH7):c.11947C>T (p.Arg3983Trp)	SNV	Pathogenic	599650	rs114621989	GRCh37: 2:196602773-196602773 GRCh38: 2:195738049-195738049
10	CCDC103	NM_213607.3(CCDC103):c.568_569dup (p.Ser190fs)	MICROSAT	Pathogenic	455029	rs746242380	GRCh37: 17:42980013-42980014 GRCh38: 17:44902645-44902646
11	DNAAF11	NM_012472.6(DNAAF11):c.436G>C (p.Asp146His)	SNV	Pathogenic	39798	rs200321595	GRCh37: 8:133645203-133645203 GRCh38: 8:132632957-132632957
12	DNAH5	NM_001369.3(DNAH5):c.8029C>T (p.Arg2677Ter)	SNV	Pathogenic	238987	rs775946081	GRCh37: 5:13793819-13793819 GRCh38: 5:13793710-13793710
13	DNAAF1	NM_178452.6(DNAAF1):c.1698+1G>A	SNV	Pathogenic	242159	rs139519641	GRCh37: 16:84208329-84208329 GRCh38: 16:84174723-84174723
14	PKD1L1	NM_138295.5(PKD1L1):c.6473+2_6473+3del	DEL	Pathogenic	235796	rs528302390	GRCh37: 7:47870812-47870813 GRCh38: 7:47831214-47831215
15	PKD1L1	NM_138295.5(PKD1L1):c.5072G>C (p.Cys1691Ser)	SNV	Likely Pathogenic	235198	rs886037834	GRCh37: 7:47886558-47886558 GRCh38: 7:47846960-47846960
16	BRWD1	NM_033656.4(BRWD1):c.5573A>T (p.Gln1858Leu)	SNV	Likely Pathogenic	982437		GRCh37: 21:40570769-40570769 GRCh38: 21:39198843-39198843
17	CCDC39	NM_181426.2(CCDC39):c.1871_1872del (p.Ile624fs)	DEL	Likely Pathogenic	565319	rs1560086701	GRCh37: 3:180359783-180359784 GRCh38: 3:180641995-180641996
18	MNS1, TEX9	NM_018365.4(MNS1):c.407_410del (p.Glu136fs)	MICROSAT	Likely Pathogenic	635005	rs1596264554	GRCh37: 15:56739085-56739088 GRCh38: 15:56446887-56446890
19	DNAH11	NM_001277115.2(DNAH11):c.3253C>T (p.Gln1085Ter)	SNV	Likely Pathogenic	1678873		GRCh37: 7:21640546-21640546 GRCh38: 7:21600928-21600928
20	CDCA7L, DNAH11	NM_001277115.2(DNAH11):c.13346_13367del (p.Arg4449fs)	DEL	Likely Pathogenic	1678874		GRCh37: 7:21940663-21940684 GRCh38: 7:21901045-21901066
21	DAND5	NM_152654.3(DAND5):c.396_397dup (p.Tyr133fs)	MICROSAT	Likely Pathogenic	1065356		GRCh37: 19:13084267-13084268 GRCh38: 19:12973453-12973454
22	CFAP53	NM_145020.5(CFAP53):c.777G>T (p.Val259=)	SNV	Likely Pathogenic	1065355		GRCh37: 18:47777851-47777851 GRCh38: 18:50251481-50251481
23	PKD1L1	NM_138295.5(PKD1L1):c.5404_5405dup (p.Asp1803fs)	DUP	Likely Pathogenic	1065357		GRCh37: 7:47882599-47882600 GRCh38: 7:47843001-47843002
24	CELSR1	NM_001378328.1(CELSR1):c.5497G>A (p.Val1833Met)	SNV	Uncertain Significance	1065358		GRCh37: 22:46794450-46794450 GRCh38: 22:46398553-46398553
25	DNAH6	NM_001370.2(DNAH6):c.6181C>T (p.Arg2061Ter)	SNV	Uncertain Significance	1065359		GRCh37: 2:84896509-84896509 GRCh38: 2:84669385-84669385
26	CFAP46	NM_001200049.3(CFAP46):c.1951C>T (p.Arg651Trp)	SNV	Uncertain Significance	1065360		GRCh37: 10:134731932-134731932 GRCh38: 10:132918428-132918428
27	CFAP52	NM_145054.5(CFAP52):c.1027G>A (p.Gly343Ser)	SNV	Uncertain Significance	1510687		GRCh37: 17:9531990-9531990 GRCh38: 17:9628673-9628673
28	CFAP52	NM_145054.5(CFAP52):c.1492A>G (p.Met498Val)	SNV	Uncertain Significance	573466	rs765338836	GRCh37: 17:9541945-9541945 GRCh38: 17:9638628-9638628
29	CFAP52	NM_145054.5(CFAP52):c.1625G>A (p.Gly542Asp)	SNV	Uncertain Significance	574037	rs552119987	GRCh37: 17:9545090-9545090 GRCh38: 17:9641773-9641773
30	CFAP52	NM_145054.5(CFAP52):c.1404G>T (p.Arg468Ser)	SNV	Uncertain Significance	581962	rs775063335	GRCh37: 17:9538805-9538805 GRCh38: 17:9635488-9635488
31	CFAP52	NM_145054.5(CFAP52):c.1430T>C (p.Val477Ala)	SNV	Uncertain Significance	582339	rs77840450	GRCh37: 17:9538831-9538831 GRCh38: 17:9635514-9635514
32	CFAP52	NM_145054.5(CFAP52):c.189delinsAGCA (p.His63delinsGlnAla)	INDEL	Uncertain Significance	641856	rs1597763121	GRCh37: 17:9489208-9489208 GRCh38: 17:9585891-9585891
33	CFAP52	NM_145054.5(CFAP52):c.1304del (p.Gly435fs)	DEL	Uncertain Significance	1285595		GRCh37: 17:9536333-9536333 GRCh38: 17:9633016-9633016
34	CFAP52	NM_145054.5(CFAP52):c.771G>T (p.Arg257Ser)	SNV	Uncertain Significance	645178	rs1389914976	GRCh37: 17:9511453-9511453 GRCh38: 17:9608136-9608136
35	CFAP52	NM_145054.5(CFAP52):c.1780C>T (p.Arg594Cys)	SNV	Uncertain Significance	841069	rs200319536	GRCh37: 17:9546432-9546432 GRCh38: 17:9643115-9643115
36	CFAP52	NM_145054.5(CFAP52):c.482C>A (p.Ala161Asp)	SNV	Uncertain Significance	841952	rs147354190	GRCh37: 17:9497584-9497584 GRCh38: 17:9594267-9594267
37	CFAP52	NM_145054.5(CFAP52):c.969A>T (p.Lys323Asn)	SNV	Uncertain Significance	861945	rs767468275	GRCh37: 17:9515740-9515740 GRCh38: 17:9612423-9612423
38	CFAP52	NM_145054.5(CFAP52):c.121T>C (p.Tyr41His)	SNV	Uncertain Significance	942263	rs371902741	GRCh37: 17:9489140-9489140 GRCh38: 17:9585823-9585823
39	CFAP52	NM_145054.5(CFAP52):c.439G>A (p.Ala147Thr)	SNV	Uncertain Significance	962973	rs748587285	GRCh37: 17:9497541-9497541 GRCh38: 17:9594224-9594224
40	CFAP52	NM_145054.5(CFAP52):c.1106G>A (p.Arg369Gln)	SNV	Uncertain Significance	1038824	rs141646758	GRCh37: 17:9532069-9532069 GRCh38: 17:9628752-9628752
41	CFAP52	NM_145054.5(CFAP52):c.1601G>C (p.Gly534Ala)	SNV	Uncertain Significance	1054061		GRCh37: 17:9545066-9545066 GRCh38: 17:9641749-9641749
42	CFAP52	NM_145054.5(CFAP52):c.531T>A (p.Ala177=)	SNV	Uncertain Significance	1394379		GRCh37: 17:9497633-9497633 GRCh38: 17:9594316-9594316
43	CFAP52	NM_145054.5(CFAP52):c.1652T>C (p.Met551Thr)	SNV	Uncertain Significance	1416427		GRCh37: 17:9545117-9545117 GRCh38: 17:9641800-9641800
44	CFAP52	NM_145054.5(CFAP52):c.244G>A (p.Gly82Arg)	SNV	Uncertain Significance	1419105		GRCh37: 17:9489263-9489263 GRCh38: 17:9585946-9585946
45	CFAP52	NM_145054.5(CFAP52):c.536+1G>T	SNV	Uncertain Significance	1443577		GRCh37: 17:9497639-9497639 GRCh38: 17:9594322-9594322
46	BRWD1	NM_033656.4(BRWD1):c.523C>T (p.His175Tyr)	SNV	Uncertain Significance	982436		GRCh37: 21:40667755-40667755 GRCh38: 21:39295829-39295829
47	BRWD1	NM_033656.4(BRWD1):c.166G>A (p.Gly56Ser)	SNV	Uncertain Significance	982435		GRCh37: 21:40684799-40684799 GRCh38: 21:39312873-39312873
48	CFAP52	NM_145054.5(CFAP52):c.734C>T (p.Ala245Val)	SNV	Uncertain Significance	1001316	rs146845939	GRCh37: 17:9503481-9503481 GRCh38: 17:9600164-9600164
49	CFAP52	NM_145054.5(CFAP52):c.509G>A (p.Arg170Gln)	SNV	Uncertain Significance	969026	rs34653219	GRCh37: 17:9497611-9497611 GRCh38: 17:9594294-9594294
50	CFAP52	NM_145054.5(CFAP52):c.199G>A (p.Val67Ile)	SNV	Uncertain Significance	544338	rs201479202	GRCh37: 17:9489218-9489218 GRCh38: 17:9585901-9585901

Sources

Expression for Situs Inversus

Search GEO for disease gene expression data for Situs Inversus.

Sources

Pathways for Situs Inversus

Pathways related to Situs Inversus according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Ciliopathies ⁷⁴	10.97	PKD1L1 INVS CFAP53 CCDC103
2	Signaling by NODAL ⁶⁶ Show member pathways Regulation of signaling by NODAL ⁶⁶	10.47	GDF1 DAND5

Sources

GO Terms for Situs Inversus

Cellular components related to Situs Inversus according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.54	CCDC103 CCDC39 CCDC40 CFAP53 DAND5 DNAAF1
2	microtubule	GO:0005874	10.19	INVS DNAI1 DNAH7 DNAH5 DNAH11
3	motile cilium	GO:0031514	10.15	MNS1 DNAH5 DNAH11 DNAAF11 CFAP300 CCDC103
4	cytoskeleton	GO:0005856	10.13	ODAD4 MNS1 INVS DNAI1 DNAH7 DNAH5
5	axoneme	GO:0005930	10.09	CCDC103 CCDC39 CCDC40 DNAAF1 DNAH11 DNAH5
6	dynein complex	GO:0030286	9.98	DNAH11 DNAH5 DNAH7 DNAI1
7	outer dynein arm	GO:0036157	9.93	DNAI1 DNAH5 CCDC103
8	9+2 motile cilium	GO:0097729	9.92	DNAH11 DNAH5 DNAI1 ODAD4
9	9+0 motile cilium	GO:0097728	9.88	ODAD4 DNAH5 DNAH11
10	cell projection	GO:0042995	9.86	CCDC103 CCDC39 CCDC40 CFAP298 CFAP300 CFAP53
11	dynein axonemal particle	GO:0120293	9.83	DNAI1 DNAAF11
12	axonemal dynein complex	GO:0005858	9.69	DNAH7 DNAH5
13	cilium	GO:0005929	9.66	CCDC103 CCDC39 CCDC40 CFAP298 CFAP53 DNAAF1

Biological processes related to Situs Inversus according to GeneCards Suite gene sharing:

(show all 23)

#	Name	GO ID	Score	Top Affiliating Genes
1	flagellated sperm motility	GO:0030317	10.26	DNAI1 DNAH5 DNAH11 DNAAF11 CCDC40 CCDC39
2	cilium assembly	GO:0060271	10.21	DNAH5 DNAAF1 CFAP53 CFAP298
3	heart development	GO:0007507	10.19	ODAD4 DNAI1 DNAH5 DNAH11 CCDC39
4	lung development	GO:0030324	10.18	CCDC39 CCDC40 DNAAF1 ODAD4
5	microtubule-based movement	GO:0007018	10.17	DNAI1 DNAH7 DNAH5 DNAH11
6	heart looping	GO:0001947	10.16	DNAAF1 CCDC40 CCDC39 CCDC103
7	determination of left/right symmetry	GO:0007368	10.15	DNAI1 DNAH5 DNAH11 DAND5 CFAP53 CCDC39
8	motile cilium assembly	GO:0044458	10.13	DNAAF11 DNAAF1 CCDC40 CCDC39
9	axonemal dynein complex assembly	GO:0070286	10.1	DNAAF11 DNAAF1 CCDC40 CCDC39 CCDC103
10	outer dynein arm assembly	GO:0036158	10.1	CCDC103 DNAAF1 DNAAF11 DNAH5 DNAI1 ODAD4
11	regulation of cilium beat frequency	GO:0003356	10.06	DNAH11 DNAAF1 CCDC40 CCDC39
12	determination of digestive tract left/right asymmetry	GO:0071907	10.03	CCDC103 CCDC39 CCDC40 DNAAF1
13	inner dynein arm assembly	GO:0036159	10.03	DNAH7 DNAAF11 DNAAF1 CCDC40 CCDC39 CCDC103
14	cerebrospinal fluid circulation	GO:0090660	10.02	CCDC39 DNAAF11 ODAD4
15	determination of liver left/right asymmetry	GO:0071910	10.01	DNAAF1 CCDC40 CCDC39
16	cilium movement	GO:0003341	10	CCDC103 CCDC39 CCDC40 CFAP53 DNAAF1 DNAAF11
17	determination of pancreatic left/right asymmetry	GO:0035469	9.99	DNAAF1 CCDC40 CCDC39
18	protein localization to motile cilium	GO:0120229	9.97	DNAAF11 DNAH11 ODAD4
19	epithelial cilium movement involved in extracellular fluid movement	GO:0003351	9.93	CCDC103 CCDC39 CCDC40 DNAAF11 DNAH11 DNAH5
20	cilium-dependent cell motility	GO:0060285	9.91	DNAH7 CCDC39
21	left/right axis specification	GO:0070986	9.9	PKD1L1 MNS1
22	regulation of cilium movement	GO:0003352	9.77	CFAP298-TCP10L CFAP298
23	epithelial cilium movement involved in determination of left/right asymmetry	GO:0060287	9.53	CCDC103 CCDC39 CCDC40 CFAP53 DNAAF1 DNAAF11

Molecular functions related to Situs Inversus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	dynein intermediate chain binding	GO:0045505	9.63	DNAH7 DNAH5 DNAH11
2	dynein light intermediate chain binding	GO:0051959	9.43	DNAH7 DNAH5 DNAH11
3	minus-end-directed microtubule motor activity	GO:0008569	9.1	DNAH7 DNAH5 DNAH11

Sources

Sources for Situs Inversus

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

SIV MCID: STS002 MIFTS: 52	Situs Inversus (SIV) Categories: Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Drugs Expand all tables

Situs Inversus (SIV)

Aliases & Classifications for Situs Inversus

MalaCards integrated aliases for Situs Inversus:

Classifications:

External Ids:

Summaries for Situs Inversus

Related Diseases for Situs Inversus

Diseases related to Situs Inversus via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Situs Inversus:

Symptoms & Phenotypes for Situs Inversus

MGI Mouse Phenotypes related to Situs Inversus:

Drugs & Therapeutics for Situs Inversus

Drugs for Situs Inversus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Cochrane evidence based reviews: situs inversus

Genetic Tests for Situs Inversus

Genetic tests related to Situs Inversus:

Anatomical Context for Situs Inversus

Organs/tissues related to Situs Inversus:

Publications for Situs Inversus

Articles related to Situs Inversus:

Genes for Situs Inversus

Genes related to Situs Inversus (14 elite genes):

Variations for Situs Inversus

ClinVar genetic disease variations for Situs Inversus:

Expression for Situs Inversus

Pathways for Situs Inversus

Pathways related to Situs Inversus according to GeneCards Suite gene sharing:

GO Terms for Situs Inversus

Cellular components related to Situs Inversus according to GeneCards Suite gene sharing:

Biological processes related to Situs Inversus according to GeneCards Suite gene sharing:

Molecular functions related to Situs Inversus according to GeneCards Suite gene sharing:

Sources for Situs Inversus