MCID: SKL003
MIFTS: 30

Skeletal Muscle Cancer

Categories: Bone diseases, Cancer diseases, Muscle diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Skeletal Muscle Cancer

MalaCards integrated aliases for Skeletal Muscle Cancer:

Name: Skeletal Muscle Cancer 11 14
Malignant Tumor of Skeletal Muscle 11
Skeletal Muscle Neoplasm 71

Classifications:



External Ids:

Disease Ontology 11 DOID:4043
NCIt 49 C6516
UMLS 71 C1334619 C1335971

Summaries for Skeletal Muscle Cancer

MalaCards based summary: Skeletal Muscle Cancer, also known as malignant tumor of skeletal muscle, is related to rhabdomyosarcoma and muscle cancer. An important gene associated with Skeletal Muscle Cancer is PAX3 (Paired Box 3), and among its related pathways/superpathways are Regulation of nuclear SMAD2/3 signaling and Mesenchymal Stem Cells and Lineage-specific Markers. Affiliated tissues include skeletal muscle and breast, and related phenotypes are normal and neoplasm

Related Diseases for Skeletal Muscle Cancer

Diseases related to Skeletal Muscle Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 297)
# Related Disease Score Top Affiliating Genes
1 rhabdomyosarcoma 31.8 TP53 RMST PTCH1 PAX7 PAX3 MYOG
2 muscle cancer 29.7 TP53 TFE3 SERPINA3 RMST RHD PTCH1
3 central nervous system rhabdomyosarcoma 10.5 PAX3 FOXO1
4 oral rhabdomyosarcoma 10.5 PAX3 MYOG MYOD1
5 bladder sarcoma 10.5 SERPINA3 MYOG
6 gallbladder sarcoma 10.5 MYOG MYOD1
7 inflammatory leiomyosarcoma 10.5 PAX7 MYOG MYOD1
8 pineal region teratoma 10.5 MYOG MYOD1
9 myocardium cancer 10.5 MYOG CD99
10 parietal lobe neoplasm 10.5 MYOG MYOD1
11 pulmonary vein leiomyosarcoma 10.5 MYOD1 CD99
12 conventional leiomyosarcoma 10.5 PAX7 MYOG
13 pseudosarcomatous fibromatosis 10.5 SERPINA3 MYOG EWSR1
14 cervical adenosarcoma 10.5 TP53 MYOG MYOD1
15 malignant triton tumor 10.5 MYOG MYOD1 MB
16 clear cell chondrosarcoma 10.5 SERPINA3 H2AC18 EWSR1
17 blastoma 10.5 TP53 MYOG MB
18 malignant epithelioid hemangioendothelioma 10.5 TFE3 SERPINA3
19 emery-dreifuss muscular dystrophy 2, autosomal dominant 10.5 PAX7 MYOG MYOD1
20 monophasic synovial sarcoma 10.5 MYOG EWSR1 CD99
21 askin's tumor 10.5 MYOG EWSR1 CD99
22 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.5 EWSR1 CD99
23 malignant granular cell myoblastoma 10.5 TFE3 SERPINA3 MB
24 prostate rhabdomyosarcoma 10.5 MYOG MYOD1
25 xanthogranulomatous pyelonephritis 10.5 TFE3 SERPINA3
26 scrotum neoplasm 10.5 SERPINA3 MYOG
27 medullomyoblastoma 10.5 MYOG MB
28 intracranial primitive neuroectodermal tumor 10.5 EWSR1 CD99
29 conventional osteosarcoma 10.5 MYOG EWSR1 CD99
30 sarcomatosis 10.5 MYOG EWSR1
31 bone benign neoplasm 10.5 TP53 SERPINA3 EWSR1
32 botryoid rhabdomyosarcoma 10.5 PAX3 MYOG MYOD1 MB
33 prostate embryonal rhabdomyosarcoma 10.5 PAX3 MYOG MYOD1 MB
34 prostate sarcoma 10.5 MYOG MYOD1
35 renal cell carcinoma, xp11-associated 10.5 TFE3 ASPSCR1
36 sweat gland disease 10.5 TP53 SERPINA3 EWSR1
37 macular holes 10.5 SERPINA3 MIR9-1 MIR199A1
38 epithelioid sarcoma 10.5 SERPINA3 H2AC18 EWSR1
39 childhood fibrosarcoma 10.5 TFE3 SERPINA3 MYOG EWSR1
40 malignant mesenchymoma 10.5 SERPINA3 MYOG MYOD1 MB
41 myoblastoma 10.5 TFE3 MYOG MYOD1 ASPSCR1
42 diffuse astrocytoma 10.5 TP53 SERPINA3 H2AC18
43 congenital fibrosarcoma 10.5 TFE3 SERPINA3 MYOG EWSR1
44 skeletal muscle neoplasm 10.5 RHD MYOG MYOD1 MB
45 lung sarcoma 10.5 MYOG EWSR1
46 extraskeletal mesenchymal chondrosarcoma 10.5 EWSR1 CD99
47 lipomatosis, multiple 10.5 TP53 SERPINA3 EWSR1
48 pleomorphic liposarcoma 10.5 TP53 SERPINA3 MYOG EWSR1
49 gas gangrene 10.5 PAX7 MYOG MYOD1 MB
50 adult fibrosarcoma 10.5 PAX3 MYOG

Graphical network of the top 20 diseases related to Skeletal Muscle Cancer:



Diseases related to Skeletal Muscle Cancer

Symptoms & Phenotypes for Skeletal Muscle Cancer

MGI Mouse Phenotypes related to Skeletal Muscle Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.91 EWSR1 FOXO1 MYOD1 MYOG PAX3 PAX7
2 neoplasm MP:0002006 9.87 EWSR1 FOXO1 MYOD1 PAX3 PAX7 PTCH1
3 no phenotypic analysis MP:0003012 9.81 FOXO1 MIR199A1 MIR9-1 MYOD1 MYOG PAX3
4 muscle MP:0005369 9.61 EWSR1 FOXO1 MB MYOD1 MYOG PAX3
5 integument MP:0010771 9.32 EWSR1 FOXO1 MIR378A MYOG PAX3 PAX7

Drugs & Therapeutics for Skeletal Muscle Cancer

Search Clinical Trials, NIH Clinical Center for Skeletal Muscle Cancer

Genetic Tests for Skeletal Muscle Cancer

Anatomical Context for Skeletal Muscle Cancer

Organs/tissues related to Skeletal Muscle Cancer:

MalaCards : Skeletal Muscle, Breast

Publications for Skeletal Muscle Cancer

Articles related to Skeletal Muscle Cancer:

(show all 17)
# Title Authors PMID Year
1
Electroactive functional microenvironments from bioactive polymers: A new strategy to address cancer. 62
35929277 2022
2
Performing in situ hybridization and quantitative PCR to assess eya2 localization and expression in zebrafish. 62
35556638 2022
3
Opposing effects of 25-hydroxy- and 1α,25-dihydroxy-vitamin D3 on pro-cachectic cytokine-and cancer conditioned medium-induced atrophy in C2C12 myotubes. 62
30834670 2019
4
Effect of Ninjin'yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice. 62
30555329 2018
5
Mandibular embryonal rhabdomyosarcoma with cartilaginous metaplasia: report of a case and review of literature. 62
29029988 2017
6
Pleomorphic rhabdomyosarcoma infiltrating thoracic spine in a 59-year-old female patient: Case report. 62
28868225 2017
7
Cytotoxicity Studies of the Extracts, Fractions, and Isolated Compound of Pseudocedrela kotschyi on Cervical Cancer (HeLa), Breast Cancer (MCF-7) and Skeletal Muscle Cancer (RD) Cells. 62
28250653 2017
8
AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell. 62
22333587 2012
9
Nephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells. 62
21423212 2011
10
Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia. 62
20193046 2010
11
Does the time-point of relapse influence outcome in pediatric rhabdomyosarcomas? 62
19165889 2009
12
PDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma. 62
18679424 2008
13
Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant mice. 62
17611698 2007
14
5-fluorouracil derivatives induce differentiation mediated by tubulin and HLA class I modulation. 62
17504194 2007
15
Identification of a new class of PAX3-FKHR target promoters: a role of the Pax3 paired box DNA binding domain. 62
16964289 2007
16
The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis. 62
16488997 2006
17
Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. 62
8221646 1993

Variations for Skeletal Muscle Cancer

Expression for Skeletal Muscle Cancer

Search GEO for disease gene expression data for Skeletal Muscle Cancer.

Pathways for Skeletal Muscle Cancer

Pathways related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.3 TFE3 MYOD1 FOXO1
2 11.23 PAX7 PAX3 MYOG MYOD1
3 10.91 TP53 MYOD1 FOXO1
4
Show member pathways
10.82 PAX7 MYOD1 MIR9-1 MIR199A1

GO Terms for Skeletal Muscle Cancer

Biological processes related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-templated transcription GO:0045893 10.15 TP53 TFE3 PTCH1 PAX3 MYOG MYOD1
2 regulation of DNA-templated transcription GO:0006355 10.02 EWSR1 FOXO1 MYOD1 MYOG PAX3 PAX7
3 negative regulation of osteoblast differentiation GO:0045668 9.71 PTCH1 MIR9-1 MIR675
4 muscle cell fate commitment GO:0042693 9.56 MYOG MYOD1
5 positive regulation of myoblast differentiation GO:0045663 9.55 MYOG MYOD1 MIR199A1
6 muscle organ development GO:0007517 9.5 PAX7 PAX3 MYOG MYOD1
7 anatomical structure development GO:0048856 9.1 PAX7 PAX3 MYOG MYOD1

Molecular functions related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.44 TP53 TFE3 PAX7 PAX3 MYOG MYOD1
2 mRNA base-pairing translational repressor activity GO:1903231 9.26 MIR9-1 MIR675 MIR378A MIR199A1

Sources for Skeletal Muscle Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....