MCID: SKL003
MIFTS: 29

Skeletal Muscle Cancer

Categories: Bone diseases, Cancer diseases, Muscle diseases

Aliases & Classifications for Skeletal Muscle Cancer

MalaCards integrated aliases for Skeletal Muscle Cancer:

Name: Skeletal Muscle Cancer 12 15
Malignant Tumor of Skeletal Muscle 12
Skeletal Muscle Neoplasm 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4043
NCIt 50 C6516
UMLS 70 C1334619 C1335971

Summaries for Skeletal Muscle Cancer

MalaCards based summary : Skeletal Muscle Cancer, also known as malignant tumor of skeletal muscle, is related to rhabdomyosarcoma and muscle cancer. An important gene associated with Skeletal Muscle Cancer is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Regulation of nuclear SMAD2/3 signaling. Affiliated tissues include skeletal muscle, and related phenotypes are integument and muscle

Related Diseases for Skeletal Muscle Cancer

Diseases related to Skeletal Muscle Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 237)
# Related Disease Score Top Affiliating Genes
1 rhabdomyosarcoma 31.6 TP53 PTCH1 PAX7 PAX3 MYOG MYOD1
2 muscle cancer 29.4 TP53 TFE3 SERPINA3 RHD PTCH1 PAX7
3 central nervous system rhabdomyosarcoma 10.6 PAX3 FOXO1
4 myocardium cancer 10.5 MYOG CD99
5 pineal region teratoma 10.5 MYOG MYOD1
6 conventional leiomyosarcoma 10.5 PAX7 MYOG MYOD1
7 inflammatory leiomyosarcoma 10.5 PAX7 MYOG MYOD1
8 prostate embryonal rhabdomyosarcoma 10.5 MYOG MYOD1
9 extraskeletal chondroma 10.5 SERPINA3 EWSR1
10 scrotum neoplasm 10.5 SERPINA3 MYOG
11 malignant epithelioid hemangioendothelioma 10.5 TFE3 SERPINA3
12 pulmonary vein leiomyosarcoma 10.5 MYOD1 CD99
13 pediatric fibrosarcoma 10.5 SERPINA3 MYOG EWSR1
14 malignant triton tumor 10.5 MYOG MYOD1 MB
15 gallbladder sarcoma 10.5 MYOG MYOD1
16 congenital fibrosarcoma 10.5 SERPINA3 MYOG EWSR1
17 malignant fibrous histiocytoma of bone 10.5 SERPINA3 MYOD1
18 calcifying epithelial odontogenic tumor 10.5 TP53 PTCH1
19 cervical adenosarcoma 10.5 TP53 MYOG MYOD1
20 prostate rhabdomyosarcoma 10.5 MYOG MYOD1
21 extracranial neuroblastoma 10.5 MYOG EWSR1
22 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.5 EWSR1 CD99
23 intracranial primitive neuroectodermal tumor 10.5 EWSR1 CD99
24 extraskeletal mesenchymal chondrosarcoma 10.5 EWSR1 CD99
25 xanthogranulomatous pyelonephritis 10.5 TFE3 SERPINA3
26 adenosarcoma 10.5 TP53 SERPINA3 MB
27 childhood malignant schwannoma 10.5 TP53 MYOG EWSR1
28 cervical neuroblastoma 10.5 MYOG EWSR1
29 perivascular tumor 10.5 TFE3 SERPINA3 ASPSCR1
30 spindle cell sarcoma 10.5 SERPINA3 MYOG EWSR1
31 sweat gland benign neoplasm 10.5 TP53 SERPINA3 EWSR1
32 adult fibrosarcoma 10.5 MYOG MYOD1
33 olfactory nerve neoplasm 10.5 MYOG EWSR1 CD99
34 cranial nerve malignant neoplasm 10.5 MYOG EWSR1 CD99
35 askin's tumor 10.5 MYOG EWSR1 CD99
36 conventional central osteosarcoma 10.5 SERPINA3 EWSR1 CD99
37 sweat gland disease 10.5 TP53 SERPINA3 EWSR1
38 undifferentiated embryonal sarcoma of the liver 10.5 TP53 SERPINA3 MYOG MYOD1
39 embryonal sarcoma 10.5 TP53 SERPINA3 MYOG MYOD1
40 botryoid rhabdomyosarcoma 10.5 PAX3 MYOG MYOD1 MB
41 malignant mesenchymoma 10.5 SERPINA3 MYOG MYOD1 MB
42 spindle cell rhabdomyosarcoma 10.5 PAX3 MYOG MYOD1 MB
43 fibroma 10.5 SERPINA3 PTCH1 CD99
44 gas gangrene 10.5 SERPINA3 MYOG MYOD1 MB
45 renal cell carcinoma, xp11-associated 10.5 TFE3 ASPSCR1
46 ewing sarcoma of bone 10.5 EWSR1 CD99
47 gliofibroma 10.5 TP53 MYOD1 CD99
48 skeletal muscle neoplasm 10.5 RHD MYOG MYOD1 MB
49 ectomesenchymoma 10.5 PAX3 MYOG FOXO1 CD99
50 diffuse astrocytoma 10.5 TP53 SERPINA3 H2AC18

Graphical network of the top 20 diseases related to Skeletal Muscle Cancer:



Diseases related to Skeletal Muscle Cancer

Symptoms & Phenotypes for Skeletal Muscle Cancer

MGI Mouse Phenotypes related to Skeletal Muscle Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.91 FOXO1 IGF2 MYOG PAX3 PAX7 PTCH1
2 muscle MP:0005369 9.81 FOXO1 IGF2 MB MYOD1 MYOG PAX3
3 no phenotypic analysis MP:0003012 9.56 FOXO1 IGF2 MYOD1 MYOG PAX3 PAX7
4 respiratory system MP:0005388 9.23 IGF2 MB MYOD1 MYOG PAX3 PAX7

Drugs & Therapeutics for Skeletal Muscle Cancer

Search Clinical Trials , NIH Clinical Center for Skeletal Muscle Cancer

Genetic Tests for Skeletal Muscle Cancer

Anatomical Context for Skeletal Muscle Cancer

MalaCards organs/tissues related to Skeletal Muscle Cancer:

40
Skeletal Muscle

Publications for Skeletal Muscle Cancer

Articles related to Skeletal Muscle Cancer:

(show all 15)
# Title Authors PMID Year
1
Histiocyte-rich rhabdomyoblastic tumor: a report of two cases and a review of the differential diagnoses. 61
32514584 2021
2
Opposing effects of 25-hydroxy- and 1α,25-dihydroxy-vitamin D3 on pro-cachectic cytokine-and cancer conditioned medium-induced atrophy in C2C12 myotubes. 61
30834670 2019
3
Effect of Ninjin'yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice. 61
30555329 2018
4
Rhabdomyosarcoma of the maxillary gingiva. 61
29497451 2018
5
Cytotoxicity Studies of the Extracts, Fractions, and Isolated Compound of Pseudocedrela kotschyi on Cervical Cancer (HeLa), Breast Cancer (MCF-7) and Skeletal Muscle Cancer (RD) Cells. 61
28250653 2017
6
Myogenin expression in vulvovaginal spindle cell lesions: analysis of a series of cases with an emphasis on diagnostic pitfalls. 61
23944986 2013
7
AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell. 61
22333587 2012
8
Nephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells. 61
21423212 2011
9
Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia. 61
20193046 2010
10
PDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma. 61
18679424 2008
11
Identification of a new class of PAX3-FKHR target promoters: a role of the Pax3 paired box DNA binding domain. 61
16964289 2007
12
The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis. 61
16488997 2006
13
Orofacial rhabdomyosarcoma in neonates and young children: a review of literature and management of four cases. 61
12110348 2002
14
Adult rhabdomyoma of the extremity: a case report and review of the literature. 61
11014574 2000
15
Multifocal recurrent adult rhabdomyoma. 61
6249488 1980

Variations for Skeletal Muscle Cancer

Expression for Skeletal Muscle Cancer

Search GEO for disease gene expression data for Skeletal Muscle Cancer.

Pathways for Skeletal Muscle Cancer

Pathways related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.45 TP53 TFE3 PAX7 PAX3 FOXO1 EWSR1
2 11.32 TFE3 MYOD1 FOXO1
3 11.23 PAX7 PAX3 MYOG MYOD1
4 10.92 TP53 MYOD1 FOXO1

GO Terms for Skeletal Muscle Cancer

Cellular components related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 9.23 TP53 TFE3 PAX7 PAX3 MYOG MYOD1

Biological processes related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.87 TP53 TFE3 PAX3 MYOG MYOD1 IGF2
2 positive regulation of transcription, DNA-templated GO:0045893 9.5 TP53 TFE3 PTCH1 PAX3 MYOG MYOD1
3 muscle organ development GO:0007517 9.46 PAX7 PAX3 MYOG MYOD1
4 myotube differentiation GO:0014902 9.4 MYOG MYOD1
5 positive regulation of skeletal muscle fiber development GO:0048743 9.37 MYOG MYOD1
6 regulation of transcription, DNA-templated GO:0006355 9.28 TP53 TFE3 PAX7 PAX3 MYOG MYOD1
7 muscle cell fate commitment GO:0042693 9.26 MYOG MYOD1

Molecular functions related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.91 TP53 TFE3 PAX7 PAX3 MYOG MYOD1
2 sequence-specific double-stranded DNA binding GO:1990837 9.8 TFE3 PAX7 PAX3 MYOG MYOD1
3 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.73 MIR675 MIR378A MIR342 MIR199A1
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.7 TP53 TFE3 PAX7 PAX3 MYOG MYOD1
5 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.65 TP53 TFE3 MYOG MYOD1 FOXO1
6 DNA binding GO:0003677 9.61 TP53 TFE3 SERPINA3 PAX7 PAX3 MYOG
7 proximal promoter sequence-specific DNA binding GO:0000987 9.5 TP53 MYOG MYOD1
8 DNA-binding transcription factor activity GO:0003700 9.17 TP53 TFE3 PAX7 PAX3 MYOG MYOD1

Sources for Skeletal Muscle Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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