MCID: SKL003
MIFTS: 35

Skeletal Muscle Cancer

Categories: Cancer diseases, Muscle diseases, Bone diseases

Aliases & Classifications for Skeletal Muscle Cancer

MalaCards integrated aliases for Skeletal Muscle Cancer:

Name: Skeletal Muscle Cancer 12 15
Skeletal Muscle Neoplasm 12 15 73
Malignant Tumor of Skeletal Muscle 12
Tumor of Skeletal Muscle 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4043 DOID:4044
NCIt 50 C6516 C6514
SNOMED-CT 68 699955004

Summaries for Skeletal Muscle Cancer

MalaCards based summary : Skeletal Muscle Cancer, also known as skeletal muscle neoplasm, is related to rhabdomyosarcoma and muscle cancer. An important gene associated with Skeletal Muscle Cancer is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Developmental Biology and Pathways in cancer. Affiliated tissues include skeletal muscle, and related phenotypes are Reduced mammosphere formation and growth/size/body region

Related Diseases for Skeletal Muscle Cancer

Diseases related to Skeletal Muscle Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 rhabdomyosarcoma 28.1 CDK4 FOXO1 IGF1R IGF2 MB MYF5
2 muscle cancer 25.6 FOXO1 IGF2 KIDINS220 MB MYF5 MYOD1
3 hemophagocytic lymphohistiocytosis, familial, 1 10.7 MYF6 MYOD1
4 botryoid rhabdomyosarcoma 10.7 MB MYOD1 PAX3
5 meninges sarcoma 10.7 IGF2 MB
6 mesenchymoma 10.6 MB MYOD1
7 spindle cell lipoma 10.5 CDK4 FOXO1
8 orbit rhabdomyosarcoma 10.5 MB MYOG
9 rhabdoid cancer 10.5 IGF1R IGF2 MYOD1
10 spindle cell rhabdomyosarcoma 10.5 MB MYOD1
11 gallbladder sarcoma 10.5 MYOD1 MYOG
12 breast rhabdomyosarcoma 10.4 MB MYOD1 MYOG
13 histiocytoma 10.4 CDK4 MB MYOD1
14 adult fibrosarcoma 10.4 MB MYOD1 MYOG
15 medullomyoblastoma 10.3 MB MYOD1 MYOG
16 undifferentiated embryonal sarcoma of the liver 10.3 CDK4 MYOD1 MYOG
17 spindle cell liposarcoma 10.3 CDK4 MYOD1 MYOG
18 embryonal sarcoma 10.2 CDK4 MYOD1 MYOG
19 central nervous system mesenchymal non-meningothelial tumor 10.1 FOXO1 MYF6 MYOD1 PAX3 PAX7
20 pleomorphic rhabdomyosarcoma 10.1 FOXO1 MB MYOD1 PAX3 PAX7
21 mixed liposarcoma 10.0 CDK4 MB
22 leiomyosarcoma 10.0 CDK4 IGF2 MB MYOG
23 childhood kidney cell carcinoma 9.9 FOXO1 PAX3 TFE3
24 skin melanoma 9.7 CDK4 CDKN1A IGF1R
25 breast cancer 9.7
26 cervical cancer 9.7
27 cervicitis 9.7
28 alveolar soft part sarcoma 9.6 MB MYF6 MYOD1 TFE3
29 malignant mesenchymoma 9.6 CDK4 CDKN1A MB MYOD1 MYOG
30 inflammatory leiomyosarcoma 9.6 MYF5 MYF6 MYOD1 MYOG PAX7
31 conventional leiomyosarcoma 9.6 MYF5 MYF6 MYOD1 MYOG PAX7
32 extraosseous ewing's sarcoma 9.5 KIDINS220 MYF5 MYF6 MYOD1 MYOG
33 ewing sarcoma 9.3 FOXO1 IGF1R IGF2 MYOD1 MYOG PAX3
34 waardenburg's syndrome 9.3 MYF5 PAX3 TFE3
35 embryonal rhabdomyosarcoma 9.0 CDK4 FOXO1 IGF2 MB MYOD1 MYOG
36 rhabdomyosarcoma 2 8.4 CDK4 FOXO1 IGF1R KIDINS220 MB MYOD1

Graphical network of the top 20 diseases related to Skeletal Muscle Cancer:



Diseases related to Skeletal Muscle Cancer

Symptoms & Phenotypes for Skeletal Muscle Cancer

GenomeRNAi Phenotypes related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CDK4 FOXO1 IGF1R IGF2 MYF5 NACA

MGI Mouse Phenotypes related to Skeletal Muscle Cancer:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.5 CDKN1A KIDINS220 IGF2 MB IGF1R CDK4
2 cellular MP:0005384 10.46 FOXO1 KIDINS220 CDKN1A IGF2 CDK4 IGF1R
3 mortality/aging MP:0010768 10.41 CDKN1A KIDINS220 IGF2 CDK4 IGF1R FOXO1
4 cardiovascular system MP:0005385 10.4 FOXO1 KIDINS220 CDKN1A IGF2 CDK4 IGF1R
5 homeostasis/metabolism MP:0005376 10.4 FOXO1 CDKN1A IGF2 CDK4 IGF1R JDP2
6 behavior/neurological MP:0005386 10.38 IGF1R FOXO1 CDKN1A IGF2 CDK4 PAX3
7 embryo MP:0005380 10.37 CDKN1A IGF2 CDK4 IGF1R FOXO1 PAX3
8 muscle MP:0005369 10.34 CDKN1A IGF2 MB IGF1R CDK4 FOXO1
9 hematopoietic system MP:0005397 10.31 JDP2 FOXO1 CDKN1A IGF2 CDK4 IGF1R
10 immune system MP:0005387 10.25 IGF1R JDP2 FOXO1 CDKN1A IGF2 CDK4
11 craniofacial MP:0005382 10.23 FOXO1 CDKN1A IGF2 IGF1R PAX3 MEF2C
12 adipose tissue MP:0005375 10.21 FOXO1 CDKN1A IGF1R JDP2 MYOD1 MYOG
13 integument MP:0010771 10.19 JDP2 FOXO1 CDKN1A IGF2 CDK4 IGF1R
14 digestive/alimentary MP:0005381 10.11 CDK4 IGF1R FOXO1 CDKN1A IGF2 PAX7
15 nervous system MP:0003631 10.11 IGF1R KIDINS220 CDKN1A IGF2 CDK4 PAX3
16 limbs/digits/tail MP:0005371 10.08 JDP2 FOXO1 CDKN1A IGF2 IGF1R PAX3
17 normal MP:0002873 10.07 CDK4 JDP2 FOXO1 MYOD1 PAX3 MYOG
18 neoplasm MP:0002006 10.06 FOXO1 CDKN1A CDK4 IGF1R MYOD1 PAX3
19 no phenotypic analysis MP:0003012 10.02 FOXO1 KIDINS220 CDKN1A IGF2 MYOD1 PAX3
20 respiratory system MP:0005388 9.97 CDKN1A IGF2 IGF1R PAX3 MYOG MYOD1
21 skeleton MP:0005390 9.8 CDKN1A IGF2 IGF1R JDP2 FOXO1 MYOD1
22 vision/eye MP:0005391 9.32 KIDINS220 CDKN1A IGF2 CDK4 PAX3 MYF6

Drugs & Therapeutics for Skeletal Muscle Cancer

Search Clinical Trials , NIH Clinical Center for Skeletal Muscle Cancer

Genetic Tests for Skeletal Muscle Cancer

Anatomical Context for Skeletal Muscle Cancer

MalaCards organs/tissues related to Skeletal Muscle Cancer:

41
Skeletal Muscle

Publications for Skeletal Muscle Cancer

Articles related to Skeletal Muscle Cancer:

# Title Authors Year
1
Cytotoxicity Studies of the Extracts, Fractions, and Isolated Compound of Pseudocedrela kotschyi on Cervical Cancer (HeLa), Breast Cancer (MCF-7) and Skeletal Muscle Cancer (RD) Cells. ( 28250653 )
2017
2
Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia. ( 20193046 )
2010

Variations for Skeletal Muscle Cancer

Expression for Skeletal Muscle Cancer

Search GEO for disease gene expression data for Skeletal Muscle Cancer.

Pathways for Skeletal Muscle Cancer

Pathways related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 CDK4 FOXO1 MEF2A MEF2C MYF5 MYF6
2 12.68 CDK4 CDKN1A FOXO1 IGF1R IGF2
3 12.07 CDKN1A FOXO1 IGF1R MEF2C PAX3 PAX7
4 11.99 CDK4 CDKN1A FOXO1 IGF1R
5 11.88 CDKN1A FOXO1 MEF2A MEF2C
6 11.81 CDK4 CDKN1A FOXO1 IGF1R IGF2
7 11.77 PAX3 PAX7 TFAP2B
8 11.76 CDKN1A MEF2A MEF2C NACA
9 11.73 FOXO1 MEF2C MYOD1
10 11.62 CDKN1A MYF6 MYOD1
11 11.52 CDK4 CDKN1A FOXO1 MEF2C MYOD1 TFE3
12 11.5 IGF1R IGF2 MEF2C
13 11.45 CDKN1A MEF2C MYOD1 PAX3
14
Show member pathways
11.37 CDKN1A IGF1R IGF2 MEF2A MEF2C MYF6
15 11.28 MEF2A MEF2C MYF5 MYOD1 PAX7
16 11.26 CDKN1A FOXO1 MYOD1
17 11.23 MEF2A MEF2C MYOD1
18
Show member pathways
11.2 MEF2A MEF2C MYF5 MYF6 MYOD1 MYOG
19 10.68 MEF2A MEF2C

GO Terms for Skeletal Muscle Cancer

Cellular components related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.83 CDK4 CDKN1A FOXO1 JDP2 MEF2A MEF2C
2 transcription factor complex GO:0005667 9.46 CDK4 MEF2A MYOD1 MYOG
3 nucleoplasm GO:0005654 9.4 CDK4 CDKN1A FOXO1 MEF2A MEF2C MYF5

Biological processes related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.9 CDK4 IGF2 MYOD1 PAX7
2 skeletal muscle cell differentiation GO:0035914 9.85 MEF2C MYF5 MYF6 MYOD1 MYOG
3 skeletal muscle tissue regeneration GO:0043403 9.83 MYF6 MYOG NACA PAX7
4 glucose homeostasis GO:0042593 9.81 FOXO1 IGF2 TFAP2B
5 positive regulation of myoblast fusion GO:1901741 9.81 MYF5 MYF6 MYOD1 MYOG
6 response to organic substance GO:0010033 9.8 CDK4 CDKN1A IGF2
7 ossification GO:0001503 9.79 IGF2 MYF5 MYOG
8 insulin receptor signaling pathway GO:0008286 9.78 FOXO1 IGF1R IGF2
9 myotube differentiation GO:0014902 9.74 MEF2C MYOD1 MYOG
10 muscle tissue morphogenesis GO:0060415 9.72 MYF5 MYF6 PAX7
11 positive regulation of myoblast differentiation GO:0045663 9.72 MEF2C MYF5 MYF6 MYOD1 MYOG
12 positive regulation of skeletal muscle fiber development GO:0048743 9.71 MYF5 MYF6 MYOD1 MYOG
13 muscle cell fate commitment GO:0042693 9.67 MYF5 MYF6 MYOD1 MYOG
14 striated muscle cell differentiation GO:0051146 9.64 IGF2 MYOD1
15 skeletal muscle tissue development GO:0007519 9.63 MEF2C MYF5 MYF6 MYOD1 MYOG PAX7
16 response to hyperoxia GO:0055093 9.62 CDK4 CDKN1A
17 positive regulation of muscle cell differentiation GO:0051149 9.43 MEF2A MEF2C MYF5 MYF6 MYOD1 MYOG
18 muscle organ development GO:0007517 9.23 MEF2A MEF2C MYF5 MYF6 MYOD1 MYOG
19 transcription, DNA-templated GO:0006351 10.34 FOXO1 JDP2 MEF2A MEF2C MYF5 MYOD1
20 regulation of transcription, DNA-templated GO:0006355 10.28 FOXO1 IGF2 JDP2 MEF2A MEF2C MYF5
21 multicellular organism development GO:0007275 10.22 CDK4 IGF1R IGF2 MEF2A MEF2C MYF5
22 cell differentiation GO:0030154 10.18 FOXO1 IGF1R MEF2A MEF2C MYF5 MYF6
23 regulation of transcription by RNA polymerase II GO:0006357 10.16 CDKN1A FOXO1 JDP2 MYF5 MYF6 MYOD1
24 positive regulation of transcription, DNA-templated GO:0045893 10.15 FOXO1 MEF2A MEF2C MYF6 MYOD1 MYOG
25 transcription by RNA polymerase II GO:0006366 10.14 MEF2A MEF2C MYF5 MYF6 MYOD1 PAX3
26 negative regulation of transcription by RNA polymerase II GO:0000122 10.07 FOXO1 IGF2 JDP2 MEF2A MEF2C TFAP2B
27 negative regulation of apoptotic process GO:0043066 10.06 CDKN1A FOXO1 IGF1R IGF2 PAX7 TFAP2B
28 positive regulation of transcription by RNA polymerase II GO:0045944 10.03 FOXO1 IGF2 MEF2A MEF2C MYF5 MYF6

Molecular functions related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.97 FOXO1 JDP2 MEF2A MEF2C MYOD1 TFAP2B
2 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.92 MEF2A MEF2C MYOG TFAP2B TFE3
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.92 JDP2 MEF2A MEF2C MYF5 MYF6 MYOD1
4 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.91 MEF2A MEF2C MYOD1 MYOG TFAP2B
5 DNA binding transcription factor activity GO:0003700 9.9 FOXO1 JDP2 MEF2A MEF2C MYF6 MYOD1
6 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001228 9.85 MYF5 MYF6 MYOD1 MYOG
7 E-box binding GO:0070888 9.76 MYF5 MYF6 MYOD1 MYOG
8 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000982 9.71 JDP2 MEF2A MEF2C
9 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding GO:0000983 9.65 MEF2C PAX7 TFAP2B
10 HMG box domain binding GO:0071837 9.56 MEF2C PAX3
11 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.43 MEF2A MEF2C MYF5 MYF6 MYOD1 MYOG
12 protein dimerization activity GO:0046983 9.23 MEF2A MEF2C MYF5 MYF6 MYOD1 MYOG
13 DNA binding GO:0003677 10.22 FOXO1 JDP2 MEF2A MEF2C MYF5 MYF6
14 protein heterodimerization activity GO:0046982 10.03 JDP2 MEF2A MEF2C MYF5 MYF6 MYOD1
15 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 10.03 FOXO1 JDP2 MEF2A MEF2C MYF5 MYF6
16 sequence-specific DNA binding GO:0043565 10.02 FOXO1 MEF2A MEF2C MYF5 MYOD1 MYOG

Sources for Skeletal Muscle Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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