MCID: SKL002
MIFTS: 25

Skeletal Muscle Neoplasm

Categories: Bone diseases, Cancer diseases, Muscle diseases

Aliases & Classifications for Skeletal Muscle Neoplasm

MalaCards integrated aliases for Skeletal Muscle Neoplasm:

Name: Skeletal Muscle Neoplasm 12 15
Tumor of Skeletal Muscle 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4044
NCIt 50 C6514
SNOMED-CT 67 699955004
UMLS 70 C1335971

Summaries for Skeletal Muscle Neoplasm

MalaCards based summary : Skeletal Muscle Neoplasm, also known as tumor of skeletal muscle, is related to skeletal muscle cancer and pineal region teratoma. An important gene associated with Skeletal Muscle Neoplasm is MYOG (Myogenin), and among its related pathways/superpathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and Myogenesis. Affiliated tissues include skeletal muscle, prostate and testis.

Related Diseases for Skeletal Muscle Neoplasm

Diseases related to Skeletal Muscle Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 skeletal muscle cancer 31.1 RHD MYOG MYOD1 MB
2 pineal region teratoma 10.2 MYOG MYOD1
3 conventional leiomyosarcoma 10.2 MYOG MYOD1
4 prostate embryonal rhabdomyosarcoma 10.2 MYOG MYOD1
5 undifferentiated embryonal sarcoma of the liver 10.1 MYOG MYOD1
6 embryonal sarcoma 10.1 MYOG MYOD1
7 inflammatory leiomyosarcoma 10.1 MYOG MYOD1
8 gallbladder sarcoma 10.1 MYOG MYOD1
9 bladder sarcoma 10.1 MYOG MYOD1
10 prostate rhabdomyosarcoma 10.1 MYOG MYOD1
11 central nervous system mesenchymal non-meningothelial tumor 10.1 MYOG MYOD1
12 adult fibrosarcoma 10.1 MYOG MYOD1
13 prostate stromal sarcoma 10.1 MYOG MYOD1
14 extraosseous ewing sarcoma 10.1 MYOG MYOD1
15 cervical adenosarcoma 10.1 MYOG MYOD1
16 mesenchymal chondrosarcoma 10.1 MYOG MYOD1
17 emery-dreifuss muscular dystrophy 2, autosomal dominant 10.1 MYOG MYOD1
18 desmoplastic small round cell tumor 10.0 MYOG MYOD1
19 leiomyosarcoma 10.0 MYOG MB
20 rhabdoid cancer 10.0 MYOG MYOD1
21 orbit embryonal rhabdomyosarcoma 10.0 MYOG MB
22 medullomyoblastoma 10.0 MYOG MB
23 orbit rhabdomyosarcoma 10.0 MYOG MB
24 bilateral retinoblastoma 10.0 MYOG MB
25 conventional fibrosarcoma 10.0 MYOD1 MB
26 hemophagocytic lymphohistiocytosis, familial, 1 9.9 MYOG MYOD1
27 lipomatosis, multiple 9.9
28 pleomorphic lipoma 9.9
29 infiltrating angiolipoma 9.9
30 angiolipoma 9.9
31 x-linked recessive disease 9.9 MYOG MYOD1
32 dedifferentiated liposarcoma 9.9 MYOG MB
33 liposarcoma 9.9 MYOG MB
34 rhabdomyosarcoma 9.8 MYOG MYOD1 MB
35 malignant triton tumor 9.8 MYOG MYOD1 MB
36 botryoid rhabdomyosarcoma 9.8 MYOG MYOD1 MB
37 malignant mesenchymoma 9.8 MYOG MYOD1 MB
38 breast rhabdomyosarcoma 9.8 MYOG MYOD1 MB
39 spindle cell rhabdomyosarcoma 9.8 MYOG MYOD1 MB
40 gas gangrene 9.8 MYOG MYOD1 MB
41 pleomorphic rhabdomyosarcoma 9.8 MYOG MYOD1 MB
42 embryonal rhabdomyosarcoma 9.8 MYOG MYOD1 MB
43 malignant fibrous histiocytoma 9.8 MYOG MYOD1 MB
44 alveolar soft part sarcoma 9.8 MYOG MYOD1 MB
45 muscle tissue disease 9.8 MYOG MYOD1 MB
46 muscular disease 9.8 MYOG MYOD1 MB
47 x-linked monogenic disease 9.8 MYOG MYOD1
48 neuromuscular disease 9.7 MYOG MYOD1 MB
49 isolated elevated serum creatine phosphokinase levels 9.7 MB KCNJ12
50 muscle cancer 9.6 RHD MYOG MYOD1 MB

Graphical network of the top 20 diseases related to Skeletal Muscle Neoplasm:



Diseases related to Skeletal Muscle Neoplasm

Symptoms & Phenotypes for Skeletal Muscle Neoplasm

Drugs & Therapeutics for Skeletal Muscle Neoplasm

Search Clinical Trials , NIH Clinical Center for Skeletal Muscle Neoplasm

Genetic Tests for Skeletal Muscle Neoplasm

Anatomical Context for Skeletal Muscle Neoplasm

MalaCards organs/tissues related to Skeletal Muscle Neoplasm:

40
Skeletal Muscle, Prostate, Testis, Liver, Breast, Pineal

Publications for Skeletal Muscle Neoplasm

Articles related to Skeletal Muscle Neoplasm:

(show all 40)
# Title Authors PMID Year
1
Histiocyte-rich rhabdomyoblastic tumor: a report of two cases and a review of the differential diagnoses. 61
32514584 2021
2
Adult type rhabdomyoma presenting as a parathyroid adenoma. 61
30537102 2019
3
Oropharyngeal Rhabdomyosarcoma with cranial nerve paralysis in a limited resource setting: a case report and review of literature. 61
31762917 2019
4
Rhabdomyosarcoma of the maxillary gingiva. 61
29497451 2018
5
Mandibular embryonal rhabdomyosarcoma with cartilaginous metaplasia: report of a case and review of literature. 61
29029988 2017
6
Pleomorphic rhabdomyosarcoma infiltrating thoracic spine in a 59-year-old female patient: Case report. 61
28868225 2017
7
Effect of Repeat Dosing of Engineered Oncolytic Herpes Simplex Virus on Preclinical Models of Rhabdomyosarcoma. 61
27751346 2016
8
Infiltrating hybrid mesenchymal tumor of skeletal muscle showing lipomatous, hemangiomatous, leiomyomatous and osseous features - An unusual soft tissue tumor providing insight into the pathogenesis of lipoma variants. 61
25817304 2015
9
Rhabdomyosarcoma in a pediatric patient: A rare case report. 61
25684925 2015
10
Overexpression of the skNAC gene in human rhabdomyosarcoma cells enhances their differentiation potential and inhibits tumor cell growth and spreading. 61
25209525 2014
11
Intramuscular capillary-type hemangioma: radiologic-pathologic correlation. 61
24487677 2014
12
Myogenin expression in vulvovaginal spindle cell lesions: analysis of a series of cases with an emphasis on diagnostic pitfalls. 61
23944986 2013
13
Comparison of genome-wide binding of MyoD in normal human myogenic cells and rhabdomyosarcomas identifies regional and local suppression of promyogenic transcription factors. 61
23230269 2013
14
Intraoral adult rhabdomyoma: a case report. 61
24288631 2013
15
Adult extracardiac rhabdomyoma of the parapharyngeal space. 61
22996720 2012
16
Rhabdomyosarcoma of the oral cavity: a case report. 61
21769278 2011
17
Does the time-point of relapse influence outcome in pediatric rhabdomyosarcomas? 61
19165889 2009
18
Rhabdomyoma of the parapharyngeal space presenting with dysphagia. 61
17965913 2008
19
Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant mice. 61
17611698 2007
20
5-fluorouracil derivatives induce differentiation mediated by tubulin and HLA class I modulation. 61
17504194 2007
21
Rhabdomyoma of the head and neck demonstrated by prenatal magnetic resonance imaging. 61
15665699 2005
22
Fine-needle aspiration of adult rhabdomyoma: a case report with review of the literature. 61
12561029 2003
23
Orofacial rhabdomyosarcoma in neonates and young children: a review of literature and management of four cases. 61
12110348 2002
24
Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. 61
11406662 2001
25
Epididymal rhabdomyoma: report of a case, including histologic and immunohistochemical findings. 61
11035587 2000
26
Adult rhabdomyoma of the extremity: a case report and review of the literature. 61
11014574 2000
27
Diminished G1 checkpoint after gamma-irradiation and altered cell cycle regulation by insulin-like growth factor II overexpression. 61
10224065 1999
28
AP-2 may contribute to IGF-II overexpression in rhabdomyosarcoma. 61
9771969 1998
29
Elevated cyclins and cyclin-dependent kinase activity in the rhabdomyosarcoma cell line RD. 61
9581851 1998
30
Rhabdomyoma of the tunica vaginalis of the testis: a histologic, immunohistochemical, and ultrastructural study. 61
9195580 1997
31
cAMP effects on myogenic gene expression in rhabdomyosarcoma cells. 61
8806451 1996
32
Detection of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma using the reverse transcriptase-polymerase chain reaction. 61
8875239 1996
33
Alpha 2a-interferon-induced differentiation of human alveolar rhabdomyosarcoma cells: correlation with down-regulation of the insulin-like growth factor type I receptor. 61
9052994 1996
34
Adult rhabdomyoma. A light microscopic, ultrastructural, virologic, and immunologic analysis. 61
8139832 1994
35
Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. 61
8221646 1993
36
Rhabdomyoma of the larynx recurring after 12 years: immunocytochemistry and differential diagnosis. 61
2597084 1989
37
Rhabdomyoma of the retroperitoneum. A report of a tumor with both adult and fetal characteristics: a study by light and electron microscopy, histochemistry, and immunochemistry. 61
3542188 1987
38
Adult rhabdomyoma: ultrastructure and immunocytochemistry. 61
6895300 1981
39
Multifocal recurrent adult rhabdomyoma. 61
6249488 1980
40
Rhabdomyoma of the pharyngeal wall. 61
875565 1977

Variations for Skeletal Muscle Neoplasm

Expression for Skeletal Muscle Neoplasm

Search GEO for disease gene expression data for Skeletal Muscle Neoplasm.

Pathways for Skeletal Muscle Neoplasm

Pathways related to Skeletal Muscle Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.93 MYOG MYOD1
2
Show member pathways
10.39 MYOG MYOD1

GO Terms for Skeletal Muscle Neoplasm

Biological processes related to Skeletal Muscle Neoplasm according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 muscle organ development GO:0007517 9.51 MYOG MYOD1
2 skeletal muscle tissue development GO:0007519 9.49 MYOG MYOD1
3 skeletal muscle cell differentiation GO:0035914 9.48 MYOG MYOD1
4 cellular response to estradiol stimulus GO:0071392 9.46 MYOG MYOD1
5 positive regulation of muscle cell differentiation GO:0051149 9.43 MYOG MYOD1
6 skeletal muscle fiber development GO:0048741 9.4 MYOG MYOD1
7 positive regulation of myoblast differentiation GO:0045663 9.37 MYOG MYOD1
8 myoblast differentiation GO:0045445 9.32 MYOG MYOD1
9 myotube differentiation GO:0014902 9.26 MYOG MYOD1
10 positive regulation of skeletal muscle fiber development GO:0048743 9.16 MYOG MYOD1
11 muscle cell fate commitment GO:0042693 8.96 MYOG MYOD1
12 skeletal muscle tissue regeneration GO:0043403 8.8 NACA MYOG MYOD1

Molecular functions related to Skeletal Muscle Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific double-stranded DNA binding GO:1990837 9.43 MYOG MYOD1 JDP2
2 proximal promoter sequence-specific DNA binding GO:0000987 9.16 MYOG MYOD1
3 chromatin DNA binding GO:0031490 8.96 MYOG MYOD1
4 E-box binding GO:0070888 8.62 MYOG MYOD1

Sources for Skeletal Muscle Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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