MCID: SKL002
MIFTS: 28

Skeletal Muscle Neoplasm

Categories: Bone diseases, Cancer diseases, Muscle diseases
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Aliases & Classifications for Skeletal Muscle Neoplasm

MalaCards integrated aliases for Skeletal Muscle Neoplasm:

Name: Skeletal Muscle Neoplasm 11 14
Tumor of Skeletal Muscle 11

Classifications:



External Ids:

Disease Ontology 11 DOID:4044
NCIt 49 C6514
SNOMED-CT 68 699955004
UMLS 71 C1335971

Summaries for Skeletal Muscle Neoplasm

MalaCards based summary: Skeletal Muscle Neoplasm, also known as tumor of skeletal muscle, is related to skeletal muscle cancer and gallbladder sarcoma. An important gene associated with Skeletal Muscle Neoplasm is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are C-MYB transcription factor network and Regulation of nuclear beta catenin signaling and target gene transcription. Affiliated tissues include skeletal muscle and testis, and related phenotypes are normal and muscle

Related Diseases for Skeletal Muscle Neoplasm

Diseases related to Skeletal Muscle Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 skeletal muscle cancer 30.3 RHD MYOG MYOD1 MYF6 MYF5 MB
2 gallbladder sarcoma 10.2 MYOG MYOD1
3 pineal region teratoma 10.2 MYOG MYOD1
4 parietal lobe neoplasm 10.1 MYOG MYOD1
5 myoblastoma 10.1 MYOG MYOD1
6 prostate rhabdomyosarcoma 10.1 MYOG MYOD1
7 central nervous system mesenchymal non-meningothelial tumor 10.1 MYOG MYOD1
8 ectomesenchymoma 10.1 MYOG MYOD1
9 prostate sarcoma 10.1 MYOG MYOD1
10 prostate stromal sarcoma 10.1 MYOG MYOD1
11 cervical adenosarcoma 10.1 MYOG MYOD1
12 spindle cell rhabdomyosarcoma 10.1 MYOG MYOD1
13 extraosseous ewing sarcoma 10.1 MYOG MYOD1
14 leiomyosarcoma 10.1 MYOG MB
15 mesenchymal chondrosarcoma 10.1 MYOG MYOD1
16 desmoplastic small round cell tumor 10.1 MYOG MYOD1
17 medullomyoblastoma 10.1 MYOG MB
18 emery-dreifuss muscular dystrophy 2, autosomal dominant 10.1 MYOG MYOD1
19 blastoma 10.1 MYOG MB
20 spindle cell sarcoma 10.0 MYOG MYOD1
21 orbit embryonal rhabdomyosarcoma 10.0 MYOG MB
22 parameningeal embryonal rhabdomyosarcoma 10.0 RHD MYOG
23 myxofibrosarcoma 10.0 MYOG MYOD1
24 chondrosarcoma, extraskeletal myxoid 10.0 MYOG MYOD1
25 inflammatory myofibroblastic tumor 10.0 MYOG MYOD1
26 progressive relapsing multiple sclerosis 9.9 RHD MYOG MYOD1
27 lipomatosis, multiple 9.9
28 short stature, onychodysplasia, facial dysmorphism, and hypotrichosis 9.9
29 mesenchymal cell neoplasm 9.9
30 infiltrating angiolipoma 9.9
31 angiolipoma 9.9
32 sarcoma 9.9 MYOG MYOD1 MB
33 prostate embryonal rhabdomyosarcoma 9.9 MYOG MYOD1 MB
34 inflammatory leiomyosarcoma 9.9 MYOG MYOD1 MYF6
35 malignant mesenchymoma 9.9 MYOG MYOD1 MB
36 malignant triton tumor 9.9 MYOG MYOD1 MB
37 breast rhabdomyosarcoma 9.9 MYOG MYOD1 MB
38 orbit rhabdomyosarcoma 9.9 MYOG MYOD1 MB
39 ullrich congenital muscular dystrophy 1 9.9 MYOG MYOD1
40 gas gangrene 9.9 MYOG MYOD1 MB
41 alveolar soft part sarcoma 9.9 MYOG MYOD1 MB
42 malignant fibrous histiocytoma 9.9 MYOG MYOD1 MB
43 ewing sarcoma 9.9 RHD MYOG MYOD1
44 isolated elevated serum creatine phosphokinase levels 9.7 MB KCNJ12
45 myotonic dystrophy 1 9.7 MYOG MYOD1 MYF5
46 autosomal recessive limb-girdle muscular dystrophy 9.7 MYOG MYOD1 MYF5
47 toxoplasmosis 9.7 RHD MB
48 muscular dystrophy, congenital, lmna-related 9.7 MYOG MYOD1 MYF5
49 hemophagocytic lymphohistiocytosis, familial, 1 9.5 MYF6 MYF5 KCNJ12
50 oral rhabdomyosarcoma 9.5 MYOG MYOD1 MYF6 MYF5

Graphical network of the top 20 diseases related to Skeletal Muscle Neoplasm:



Diseases related to Skeletal Muscle Neoplasm

Symptoms & Phenotypes for Skeletal Muscle Neoplasm

MGI Mouse Phenotypes related to Skeletal Muscle Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.72 MYF5 MYF6 MYOD1 MYOG NACA
2 muscle MP:0005369 9.63 MB MYF5 MYF6 MYOD1 MYOG NACA
3 no phenotypic analysis MP:0003012 9.56 MYF5 MYF6 MYOD1 MYOG
4 embryo MP:0005380 9.35 MB MYF5 MYF6 MYOG NACA
5 respiratory system MP:0005388 9.02 MB MYF5 MYF6 MYOD1 MYOG

Drugs & Therapeutics for Skeletal Muscle Neoplasm

Search Clinical Trials, NIH Clinical Center for Skeletal Muscle Neoplasm

Genetic Tests for Skeletal Muscle Neoplasm

Anatomical Context for Skeletal Muscle Neoplasm

Organs/tissues related to Skeletal Muscle Neoplasm:

MalaCards : Skeletal Muscle, Testis

Publications for Skeletal Muscle Neoplasm

Articles related to Skeletal Muscle Neoplasm:

(show all 40)
# Title Authors PMID Year
1
Histiocyte-rich rhabdomyoblastic tumor: a report of two cases and a review of the differential diagnoses. 62
32514584 2021
2
Adult type rhabdomyoma presenting as a parathyroid adenoma. 62
30537102 2019
3
Oropharyngeal Rhabdomyosarcoma with cranial nerve paralysis in a limited resource setting: a case report and review of literature. 62
31762917 2019
4
Rhabdomyosarcoma of the maxillary gingiva. 62
29497451 2018
5
Mandibular embryonal rhabdomyosarcoma with cartilaginous metaplasia: report of a case and review of literature. 62
29029988 2017
6
Pleomorphic rhabdomyosarcoma infiltrating thoracic spine in a 59-year-old female patient: Case report. 62
28868225 2017
7
Effect of Repeat Dosing of Engineered Oncolytic Herpes Simplex Virus on Preclinical Models of Rhabdomyosarcoma. 62
27751346 2016
8
Infiltrating hybrid mesenchymal tumor of skeletal muscle showing lipomatous, hemangiomatous, leiomyomatous and osseous features - An unusual soft tissue tumor providing insight into the pathogenesis of lipoma variants. 62
25817304 2015
9
Rhabdomyosarcoma in a pediatric patient: A rare case report. 62
25684925 2015
10
Overexpression of the skNAC gene in human rhabdomyosarcoma cells enhances their differentiation potential and inhibits tumor cell growth and spreading. 62
25209525 2014
11
Intramuscular capillary-type hemangioma: radiologic-pathologic correlation. 62
24487677 2014
12
Myogenin expression in vulvovaginal spindle cell lesions: analysis of a series of cases with an emphasis on diagnostic pitfalls. 62
23944986 2013
13
Comparison of genome-wide binding of MyoD in normal human myogenic cells and rhabdomyosarcomas identifies regional and local suppression of promyogenic transcription factors. 62
23230269 2013
14
Intraoral adult rhabdomyoma: a case report. 62
24288631 2013
15
Adult extracardiac rhabdomyoma of the parapharyngeal space. 62
22996720 2012
16
Rhabdomyosarcoma of the oral cavity: a case report. 62
21769278 2011
17
Does the time-point of relapse influence outcome in pediatric rhabdomyosarcomas? 62
19165889 2009
18
Rhabdomyoma of the parapharyngeal space presenting with dysphagia. 62
17965913 2008
19
Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant mice. 62
17611698 2007
20
5-fluorouracil derivatives induce differentiation mediated by tubulin and HLA class I modulation. 62
17504194 2007
21
Rhabdomyoma of the head and neck demonstrated by prenatal magnetic resonance imaging. 62
15665699 2005
22
Fine-needle aspiration of adult rhabdomyoma: a case report with review of the literature. 62
12561029 2003
23
Orofacial rhabdomyosarcoma in neonates and young children: a review of literature and management of four cases. 62
12110348 2002
24
Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. 62
11406662 2001
25
Epididymal rhabdomyoma: report of a case, including histologic and immunohistochemical findings. 62
11035587 2000
26
Adult rhabdomyoma of the extremity: a case report and review of the literature. 62
11014574 2000
27
Diminished G1 checkpoint after gamma-irradiation and altered cell cycle regulation by insulin-like growth factor II overexpression. 62
10224065 1999
28
AP-2 may contribute to IGF-II overexpression in rhabdomyosarcoma. 62
9771969 1998
29
Elevated cyclins and cyclin-dependent kinase activity in the rhabdomyosarcoma cell line RD. 62
9581851 1998
30
Rhabdomyoma of the tunica vaginalis of the testis: a histologic, immunohistochemical, and ultrastructural study. 62
9195580 1997
31
cAMP effects on myogenic gene expression in rhabdomyosarcoma cells. 62
8806451 1996
32
Detection of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma using the reverse transcriptase-polymerase chain reaction. 62
8875239 1996
33
Alpha 2a-interferon-induced differentiation of human alveolar rhabdomyosarcoma cells: correlation with down-regulation of the insulin-like growth factor type I receptor. 62
9052994 1996
34
Adult rhabdomyoma. A light microscopic, ultrastructural, virologic, and immunologic analysis. 62
8139832 1994
35
Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. 62
8221646 1993
36
Rhabdomyoma of the larynx recurring after 12 years: immunocytochemistry and differential diagnosis. 62
2597084 1989
37
Rhabdomyoma of the retroperitoneum. A report of a tumor with both adult and fetal characteristics: a study by light and electron microscopy, histochemistry, and immunochemistry. 62
3542188 1987
38
Adult rhabdomyoma: ultrastructure and immunocytochemistry. 62
6895300 1981
39
Multifocal recurrent adult rhabdomyoma. 62
6249488 1980
40
Rhabdomyoma of the pharyngeal wall. 62
875565 1977

Variations for Skeletal Muscle Neoplasm

Expression for Skeletal Muscle Neoplasm

Search GEO for disease gene expression data for Skeletal Muscle Neoplasm.

Pathways for Skeletal Muscle Neoplasm

Pathways related to Skeletal Muscle Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.22 MYOD1 MYF6
2 11.11 MYOG MYF5
3 11.11 MYOG MYOD1 MYF5
4 10.69 MYOD1 MYF5
5 10.4 MYOG MYOD1 MYF6 MYF5

GO Terms for Skeletal Muscle Neoplasm

Biological processes related to Skeletal Muscle Neoplasm according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.16 NACA MYOG MYOD1 MYF6 MYF5
2 skeletal muscle tissue development GO:0007519 9.92 MYF5 MYF6 MYOD1 MYOG
3 muscle organ development GO:0007517 9.88 MYOG MYOD1 MYF6 MYF5
4 skeletal muscle cell differentiation GO:0035914 9.86 MYOG MYOD1 MYF6 MYF5
5 somitogenesis GO:0001756 9.84 MYF6 MYF5
6 cellular response to estradiol stimulus GO:0071392 9.83 MYOG MYOD1
7 skeletal muscle fiber development GO:0048741 9.8 MYOG MYOD1
8 positive regulation of myoblast differentiation GO:0045663 9.76 MYOG MYOD1 MYF6 MYF5
9 muscle tissue morphogenesis GO:0060415 9.73 MYF6 MYF5
10 anatomical structure development GO:0048856 9.67 MYOG MYOD1 MYF6 MYF5
11 positive regulation of skeletal muscle fiber development GO:0048743 9.56 MYOG MYOD1 MYF6 MYF5
12 skeletal muscle tissue regeneration GO:0043403 9.48 MYOD1 NACA
13 myotube differentiation GO:0014902 9.46 MYOG MYOD1
14 muscle cell fate commitment GO:0042693 9.23 MYOG MYOD1 MYF6 MYF5

Molecular functions related to Skeletal Muscle Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.86 MYOG MYOD1 MYF6 MYF5
2 protein dimerization activity GO:0046983 9.5 MYOG MYOD1 MYF6 MYF5
3 E-box binding GO:0070888 9.23 MYOG MYOD1 MYF6 MYF5
4 DNA-binding transcription activator activity GO:0001216 9.16 MYOG MYOD1

Sources for Skeletal Muscle Neoplasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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