MCID: SKL001
MIFTS: 35

Skeletal Tuberculosis

Categories: Bone diseases, Infectious diseases

Aliases & Classifications for Skeletal Tuberculosis

MalaCards integrated aliases for Skeletal Tuberculosis:

Name: Skeletal Tuberculosis 12 15 17
Tuberculosis, Osteoarticular 44 70
Osteoarticular Tuberculosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1639
ICD9CM 34 015.9
MeSH 44 D014394
SNOMED-CT 67 154287006
ICD10 32 A18.0
UMLS 70 C0041324

Summaries for Skeletal Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of lesions located in bone.

MalaCards based summary : Skeletal Tuberculosis, also known as tuberculosis, osteoarticular, is related to tenosynovitis and enthesopathy. An important gene associated with Skeletal Tuberculosis is CFHR2 (Complement Factor H Related 2), and among its related pathways/superpathways are Folate Metabolism and African trypanosomiasis. The drugs Fluorodeoxyglucose F18 and Deoxyglucose have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney.

Related Diseases for Skeletal Tuberculosis

Diseases related to Skeletal Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 347)
# Related Disease Score Top Affiliating Genes
1 tenosynovitis 30.7 TNF CRP
2 enthesopathy 30.5 TNF CRP
3 osteomyelitis 30.2 TNF IFNG CRP
4 spondylitis 30.0 TNF IFNG CRP
5 otitis media 29.9 TNF IFNG CRP
6 multidrug-resistant tuberculosis 29.9 TNF IFNG
7 bursitis 29.9 TNF CRP
8 cervical adenitis 29.8 PDE6B CRP
9 lymph node tuberculosis 29.7 TNF IFNG CRP
10 bone inflammation disease 29.7 TNF IFNG CRP
11 meningitis 29.7 TNF IFNG CRP
12 brucellosis 29.7 TNF IFNG CRP
13 pericarditis 29.7 TNF IFNG CRP
14 arthropathy 29.7 TNF IFNG CRP
15 spondyloarthropathy 1 29.6 TNF CRP CFHR2
16 immune deficiency disease 29.6 TNF IFNG CRP CFHR2
17 end stage renal disease 29.6 TNF CRP CFHR1
18 lymphadenitis 29.5 TNF IFNG CRP
19 soft tissue sarcoma 29.5 TNF IFNG CRP
20 septic arthritis 29.5 TNF IFNG CRP
21 pleurisy 29.5 TNF IFNG CRP
22 acquired immunodeficiency syndrome 29.5 TNF IFNG CRP
23 disease by infectious agent 29.2 TNF IFNG CRP CFHR2
24 lyme disease 29.2 TNF CRP CFHR2 CFHR1
25 thrombocytopenia 29.1 TNF IFNG CRP CFHR1
26 miliary tuberculosis 29.0 TNF PDE6B IFNG CRP
27 mycobacterium tuberculosis 1 10.5
28 late congenital syphilis 10.2 PPP2R3C CRP
29 nonbacterial thrombotic endocarditis 10.2 CRP CFHR2
30 plica syndrome 10.2
31 ankylosis 10.2
32 synovitis 10.2
33 orbital granuloma 10.2 ESX1 CRP
34 henoch-schoenlein purpura 10.2 CRP CFHR2
35 drug reaction with eosinophilia and systemic symptoms 10.2 TNF CRP
36 petrositis 10.2 IFNG CRP
37 panophthalmitis 10.2 IFNG CRP
38 anterior scleritis 10.2 TNF CRP
39 berylliosis 10.2 IFNG CFHR2
40 rheumatoid arthritis interstitial lung disease 10.2 TNF CRP
41 posterior scleritis 10.2 TNF CRP
42 tuberculous peritonitis 10.2 IFNG CRP
43 tuberculous epididymitis 10.2 TNF CRP
44 pericardial tuberculosis 10.2 IFNG CRP
45 meningovascular neurosyphilis 10.2 TNF CRP
46 critical illness polyneuropathy 10.2 TNF CRP
47 louse-borne relapsing fever 10.2 TNF CRP
48 tertiary syphilis 10.2 TNF CRP
49 arachnoiditis 10.2 TNF CRP
50 cerebritis 10.2 TNF CRP

Graphical network of the top 20 diseases related to Skeletal Tuberculosis:



Diseases related to Skeletal Tuberculosis

Symptoms & Phenotypes for Skeletal Tuberculosis

Drugs & Therapeutics for Skeletal Tuberculosis

Drugs for Skeletal Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fluorodeoxyglucose F18
2 Deoxyglucose
3 Antiviral Agents
4 Antimetabolites
5 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Positron Emission Tomography in Extrapulmonary Tuberculosis Completed NCT01613196

Search NIH Clinical Center for Skeletal Tuberculosis

Cochrane evidence based reviews: tuberculosis, osteoarticular

Genetic Tests for Skeletal Tuberculosis

Anatomical Context for Skeletal Tuberculosis

MalaCards organs/tissues related to Skeletal Tuberculosis:

40
Bone, Bone Marrow, Kidney, Breast, Skin

Publications for Skeletal Tuberculosis

Articles related to Skeletal Tuberculosis:

(show top 50) (show all 329)
# Title Authors PMID Year
1
Multifocal skeletal tuberculosis with mycobacteremia after kidney transplantation: A case report. 61
33655691 2021
2
Epidemiology of skeletal tuberculosis in Beijing, China: a 10-year retrospective analysis of data. 61
32556926 2020
3
Costal tubercular osteomyelitis presenting as an orbital abscess. 61
33050754 2020
4
Examining variation in skeletal tuberculosis in a late pre-contact population from the eastern mountains of Peru. 61
32416540 2020
5
Tuberculous Dactylitis: A Rare Form of Skeletal Tuberculosis. 61
32735417 2020
6
Skull base and calvarial tuberculosis presenting as chronic meningitis. 61
32825882 2020
7
Screening and identification of serum biomarkers of osteoarticular tuberculosis based on mass spectrometry. 61
32162728 2020
8
Comparison of Lowenstein-Jensen medium and MGIT culture system for recovery of Mycobacterium tuberculosis from abscess samples. 61
31973887 2020
9
Tuberculosis, a great masquerader: A case series unveiling rare sites of musculoskeletal involvement through imaging. 61
33101726 2020
10
Localization of acute pyelonephritis in pyrexia of unknown origin using FDG PET/CT. 61
32064288 2020
11
Neurological recovery after early decompression for dorsal Pott's spine. 61
31874383 2020
12
Spinal tuberculosis: a comprehensive review for the modern spine surgeon. 61
31102727 2019
13
Tuberculous retropharyngeal abscess with Pott disease and tuberculous abscess of the chest wall: A case report. 61
31277156 2019
14
Impact of urbanization on tuberculosis and leprosy prevalence in medieval Denmark. 61
30942817 2019
15
Improved case detection using Xpert Mycobacterium tuberculosis/rifampicin assay in skeletal tuberculosis. 61
30880713 2018
16
Tuberculous sacroiliitis with secondary psoas abscess in an older patient: a case report. 61
30119703 2018
17
The Epidemiology of Skeletal Tuberculosis in Northeast of Iran: A Review of 229 Cases. 61
30046206 2018
18
[Osteoarticular tuberculosis nosology and diagnostic pitfalls]. 61
29676872 2018
19
Isolated Iliac Crest Tuberculosis: A Case Report. 61
29794486 2018
20
[Microbiological diagnosis of tuberculosis. 20 years in the province of Soria. Performance and basic opportunities of improvement]. 61
29564867 2018
21
Drug resistant Skeletal Tuberculosis in a tertiary care centre in South India. 61
29628698 2018
22
Pott's Disease Resulting in Complete Cervical Vertebral Destruction. 61
29358061 2018
23
Efficacy of alternate day Directly Observed Treatment Short-course (DOTS) in skeletal tuberculosis - A retrospective study. 61
29332653 2018
24
Case of victims of modern imaging technology: Increased information noise concealing the diagnosis. 61
29354211 2017
25
Clinical and diagnostic features of trochanteric tuberculosis. 61
28660603 2017
26
Ankle tuberculosis. A case in childhood. 61
28755924 2017
27
Skeletal Tuberculosis. 61
28155042 2017
28
Multifocal Tubercular Dactylitis: A Rare Presentation of Skeletal Tuberculosis in an Adult. 61
28764233 2017
29
Multifocal tuberculous osteomyelitis in a 3-year-old child. 61
27458046 2017
30
Tubercular dactylitis in children. 61
27392303 2017
31
Hand and wrist tuberculosis in paediatric patients - our experience in 44 patients. 61
27111553 2017
32
Isolated tuberculous arthritis of the ankle: a case report and review of the literature. 61
30455563 2017
33
Multifocal pure tubercular osteomyelitis: An unusual presentation in childhood. 61
28410697 2017
34
Intra-medullary Tuberculomas: Case Series. 61
28377860 2017
35
Tuberculous arthritis of the hip with Staphylococcus aureus superinfection. 61
27221797 2016
36
Case report: a student of Asian origin with Pott's disease. 61
27141824 2016
37
[Skeletal sarcoidosis]. 61
27638825 2016
38
Trends of spinal tuberculosis research (1994-2015): A bibliometric study. 61
27661044 2016
39
Tuberculous spondylitis diagnosed through Xpert MTB/RIF assay in urine: a case report. 61
27670679 2016
40
Tuberculous Dactylitis : Case Presentation and Functional outcome. 61
28116260 2016
41
Tubercular osteomyelitis of calcaneum bone: A rare occurrence. 61
27865244 2016
42
Tuberculous Dactylitis: An Uncommon Presentation of Skeletal Tuberculosis. 61
27358553 2016
43
Epidemiological features of skeletal tuberculosis at an urban district tuberculosis centre. 61
27451817 2016
44
Multifocal skeletal tuberculosis: A case report. 61
27073438 2016
45
Tuberculosis in early medieval Switzerland--osteological and molecular evidence. 61
26826871 2016
46
A Rare Case of Tuberculosis with Sacrococcygeal Involvement Miming a Neoplasm. 61
27525144 2016
47
[Multifocal skeletal tuberculosis simulating a soft-tissue sarcoma]. 61
26228256 2016
48
[Granulomatous spondylodiscitis: due mainly to tuberculosis but lymphoma cannot be excluded]. 61
28292061 2016
49
Primary Extrapulmonary Multidrug-Resistant Tuberculosis of the Sternum without HIV Infection. 61
26894135 2016
50
The beginnings of Orthopedic Surgery at the Mayo Clinic: A Review of the First Orthopedic Patients who Presented Over 100 Years Ago. 61
27528834 2016

Variations for Skeletal Tuberculosis

Expression for Skeletal Tuberculosis

Search GEO for disease gene expression data for Skeletal Tuberculosis.

Pathways for Skeletal Tuberculosis

GO Terms for Skeletal Tuberculosis

Biological processes related to Skeletal Tuberculosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of chemokine production GO:0032722 9.51 TNF IFNG
2 microglial cell activation GO:0001774 9.49 TNF IFNG
3 positive regulation of osteoclast differentiation GO:0045672 9.48 TNF IFNG
4 positive regulation of amyloid-beta formation GO:1902004 9.46 TNF IFNG
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.43 TNF IFNG
6 astrocyte activation GO:0048143 9.4 TNF IFNG
7 negative regulation of amyloid-beta clearance GO:1900222 9.37 TNF IFNG
8 cytolysis by host of symbiont cells GO:0051838 9.32 CFHR2 CFHR1
9 negative regulation of lipid storage GO:0010888 9.26 TNF CRP
10 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 TNF IFNG
11 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 TNF IFNG
12 positive regulation of nitrogen compound metabolic process GO:0051173 8.62 TNF IFNG

Sources for Skeletal Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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