MCID: SKL001
MIFTS: 37

Skeletal Tuberculosis

Categories: Infectious diseases, Bone diseases

Aliases & Classifications for Skeletal Tuberculosis

MalaCards integrated aliases for Skeletal Tuberculosis:

Name: Skeletal Tuberculosis 12 15
Tuberculosis, Osteoarticular 44 73
Osteoarticular Tuberculosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1639
ICD10 33 A18.0
ICD9CM 35 015 015.9
MeSH 44 D014394
UMLS 73 C0041324

Summaries for Skeletal Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of lesions located in bone.

MalaCards based summary : Skeletal Tuberculosis, also known as tuberculosis, osteoarticular, is related to ovarian squamous cell carcinoma and enamel caries. An important gene associated with Skeletal Tuberculosis is SLC25A46 (Solute Carrier Family 25 Member 46). The drugs Ethambutol and Isoniazid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and lung, and related phenotypes are cardiovascular system and immune system

Related Diseases for Skeletal Tuberculosis

Diseases related to Skeletal Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 ovarian squamous cell carcinoma 10.9 CRP SMUG1
2 enamel caries 10.9 AMELX AMELY
3 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 10.9 AMELX AMELY
4 epulis 10.9 AMELX AMELY
5 dissociative amnesia 10.8 CFP SMUG1
6 freemartinism 10.8 AMELX AMELY
7 amelogenesis imperfecta, type ie 10.8 AMELX AMELY
8 retinitis pigmentosa 59 10.8 AMELX AMELY
9 familial cold autoinflammatory syndrome 2 10.7 CRP NLRP3
10 tolosa-hunt syndrome 10.7 NLRP3 SMUG1
11 cryopyrin-associated periodic syndrome 10.7 CRP NLRP3
12 dental abscess 10.7 AMELX CRP
13 acute maxillary sinusitis 10.6 CRP F9
14 dental pulp necrosis 10.6 AMELX AMELY
15 nutmeg liver 10.6 CP HP
16 anthracosilicosis 10.6 CFP CP SMUG1
17 peptic ulcer perforation 10.6 AMELX AMELY CRP
18 punctate palmoplantar keratoderma 10.6 FLNA MRAP
19 laryngeal tuberculosis 10.6 SLC25A46 SMUG1
20 chronic meningitis 10.6 CRP NLRP3
21 acquired angioedema 10.6 CRP HP
22 mouth disease 10.6 AMELX AMELY CRP
23 pyuria 10.6 CRP MRAP
24 tenosynovitis 10.5 CRP MRAP
25 aortitis 10.5 CRP MRAP SMUG1
26 spinal disease 10.4 CRP MRAP
27 immune system disease 10.4 CRP F9 IL3
28 meningitis 10.4 CFP CRP NLRP3
29 arthropathy 10.4 CRP F9 NLRP3
30 melancholia 10.3 CRP HP
31 chondromalacia 10.3 SMUG1 TNFRSF10A
32 bursitis 10.3 CRP MRAP
33 posterior scleritis 10.2 MRAP TNFRSF10A
34 tendinitis 10.2 CRP MRAP
35 cartilage disease 10.2 CRP SMUG1 TNFRSF10A
36 central nervous system vasculitis 10.2 CRP SMUG1 TNFRSF10A
37 temporal arteritis 10.2 CRP SMUG1 TNFRSF10A
38 felty syndrome 10.1 IL3 TNFRSF10A
39 geniculate herpes zoster 10.1 HP TNFRSF10A
40 vaginal discharge 10.1 FLNA HP
41 deficiency anemia 10.0 CP CRP HP IL3
42 extrapulmonary tuberculosis 10.0
43 palindromic rheumatism 10.0 CRP MRAP TNFRSF10A
44 cervicitis 9.9 FLNA MRAP
45 systemic lupus erythematosus 9.8
46 lupus erythematosus 9.8
47 slipped capital femoral epiphysis 9.8
48 osteomyelitis 9.7
49 spondyloarthropathy 9.7
50 langerhans cell histiocytosis 9.6

Graphical network of the top 20 diseases related to Skeletal Tuberculosis:



Diseases related to Skeletal Tuberculosis

Symptoms & Phenotypes for Skeletal Tuberculosis

MGI Mouse Phenotypes related to Skeletal Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.61 CRP F9 FLNA HP LARGE1 MBNL1
2 immune system MP:0005387 9.32 CP CRP F9 FLNA HP LARGE1

Drugs & Therapeutics for Skeletal Tuberculosis

Drugs for Skeletal Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethambutol Approved Phase 4 74-55-5 3279 14052
2
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
3
Pyrazinamide Approved, Investigational Phase 4 98-96-4 1046
4
Rifampicin Approved Phase 4 13292-46-1 5458213 5381226
5 Anti-Bacterial Agents Phase 4
6 Antibiotics, Antitubercular Phase 4
7 Anti-Infective Agents Phase 4,Not Applicable
8 Antimetabolites Phase 4,Not Applicable
9 Antitubercular Agents Phase 4,Phase 3
10 Cytochrome P-450 CYP3A Inducers Phase 4
11 Hypolipidemic Agents Phase 4
12 Lipid Regulating Agents Phase 4
13 Nucleic Acid Synthesis Inhibitors Phase 4
14 Antiviral Agents Not Applicable
15 Deoxyglucose Not Applicable
16 Fluorodeoxyglucose F18 Not Applicable
17
Cobalt Not Applicable 7440-48-4 104729
18 Micronutrients Not Applicable
19 Trace Elements Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Optimal Duration of Preoperative Anti-tuberculosis Treatment of Spinal Tuberculosis Unknown status NCT02477852 Phase 4 Isoniazid;Rifampicin;Ethambutol;Pyrazinamide
2 Treatment Duration for Abdominal Tuberculosis Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
3 Positron Emission Tomography in Extrapulmonary Tuberculosis Completed NCT01613196 Not Applicable
4 Early Outcomes of Radical Debridement Versus no Debridement Under Different Surgical Procedures Completed NCT02638272 Not Applicable
5 Cobalt Alloy Pedicle Screw Implantation for Severe Kyphosis Deformity in Spinal Tuberculosis Active, not recruiting NCT02971644 Not Applicable

Search NIH Clinical Center for Skeletal Tuberculosis

Cochrane evidence based reviews: tuberculosis, osteoarticular

Genetic Tests for Skeletal Tuberculosis

Anatomical Context for Skeletal Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Skeletal Tuberculosis:

19
Bone

MalaCards organs/tissues related to Skeletal Tuberculosis:

41
Bone, Lung, Bone Marrow

Publications for Skeletal Tuberculosis

Articles related to Skeletal Tuberculosis:

(show top 50) (show all 125)
# Title Authors Year
1
Efficacy of alternate day Directly Observed Treatment Short-course (DOTS) in skeletal tuberculosis - A retrospective study. ( 29332653 )
2018
2
Drug resistant Skeletal Tuberculosis in a tertiary care centre in South India. ( 29628698 )
2018
3
Multifocal Tubercular Dactylitis: A Rare Presentation of Skeletal Tuberculosis in an Adult. ( 28764233 )
2017
4
Skeletal Tuberculosis. ( 28155042 )
2017
5
Multifocal skeletal tuberculosis: A case report. ( 27073438 )
2016
6
Epidemiological features of skeletal tuberculosis at an urban district tuberculosis centre. ( 27451817 )
2016
7
Tuberculous Dactylitis: An Uncommon Presentation of Skeletal Tuberculosis. ( 27358553 )
2016
8
Multifocal skeletal tuberculosis in an immunocompetent patient: a case report. ( 26092386 )
2015
9
Multifocal Skeletal Tuberculosis Mimicking Langerhans Cell Histiocytosis in a Child: a Case Report With a Long-Term Follow-Up. ( 26744631 )
2015
10
Treatment paradox in musculo-skeletal tuberculosis in an immunocompetent adult male; a case report from a tertiary care hospital. ( 26046019 )
2015
11
Computed tomography detection of clinically unsuspected skeletal tuberculosis. ( 26338020 )
2015
12
FDG PET/CT in Monitoring Antituberculosis Therapy in Patient With Widespread Skeletal Tuberculosis. ( 26284767 )
2015
13
Coccidioidomycosis masquerading as skeletal tuberculosis: an imported case and review of coccidioidomycosis in India. ( 24265192 )
2014
14
The diagnosis of atypical skeletal tuberculosis is challenging. ( 25002383 )
2014
15
Potential role of F18 FDG PET-CT as an imaging biomarker for the noninvasive evaluation in uncomplicated skeletal tuberculosis: a prospective clinical observational study. ( 25070791 )
2014
16
18F-FDG PET/CT in a case of multifocal skeletal tuberculosis without pulmonary disease and potential role for monitoring treatment response. ( 24561689 )
2014
17
A case of skeletal tuberculosis and psoas abscess: disease activity evaluated using 18a88F-fluorodeoxyglucose positron emission tomography-computed tomography. ( 24225333 )
2013
18
Multifocal skeletal tuberculosis presenting as paraplegia: A case report. ( 23963266 )
2013
19
Tuberculous dactylitis (spina ventosa) with concomitant ipsilateral axillary scrofuloderma in an immunocompetent child: A rare presentation of skeletal tuberculosis. ( 23977657 )
2013
20
Skeletal tuberculosis presenting as a small cystic lesion in the medial femoral condyle. ( 25207301 )
2013
21
Skeletal tuberculosis following proximal tibia fracture. ( 23446371 )
2013
22
Multifocal skeletal tuberculosis involving the lumbar spine and iliac bone, mimicking a malignant bone tumour: a case report. ( 25279059 )
2012
23
Multifocal skeletal tuberculosis. ( 23275855 )
2012
24
Atypical disseminated skeletal tuberculosis mimicking metastasis on PET-CT and MRI. ( 23064577 )
2012
25
Multifocal skeletal tuberculosis. ( 25874102 )
2012
26
Diagnostic performance of an enzyme-linked immunospot assay for interferon-I^ in skeletal tuberculosis. ( 21240673 )
2011
27
Multifocal skeletal tuberculosis masquerading as metastatic disease. ( 22295316 )
2011
28
New skeletal tuberculosis cases in past populations from Western Hungary (Transdanubia). ( 21530965 )
2011
29
Multifocal skeletal tuberculosis: experience in diagnosis and treatment. ( 19359113 )
2010
30
Multifocal skeletal tuberculosis in 2 immunocompetent children. ( 21041269 )
2010
31
Diagnostic role of whole body bone scintigraphy in atypical skeletal tuberculosis resembling multiple metastases: a case report. ( 19946546 )
2009
32
Multifocal skeletal tuberculosis in children. ( 19182762 )
2009
33
Pyomyositis with multifocal osteomyelitis--an uncommon presentation of skeletal tuberculosis. ( 20329428 )
2009
34
Skeletal tuberculosis in children in the Western world: 18 new cases with a review of the literature. ( 19543761 )
2009
35
Concomitant cutaneous metastatic tuberculous abscesses and multifocal skeletal tuberculosis. ( 19882018 )
2008
36
Pain in the elbow: a rare presentation of skeletal tuberculosis. ( 17964818 )
2008
37
Scapholunate dissociation: a rare presentation of TB wrist in a case of multi-focal skeletal tuberculosis. ( 18807747 )
2008
38
Multifocal skeletal tuberculosis presenting as multiple bone cysts. ( 18185888 )
2007
39
The prospect of incidental detection of unsuspected skeletal tuberculosis by bone scintigraphy should not be overlooked. ( 17515748 )
2007
40
Skeletal tuberculosis mimicking seronegative spondyloarthropathy. ( 18173033 )
2007
41
Multifocal skeletal tuberculosis: a report of three cases. ( 16789468 )
2006
42
Multifocal skeletal tuberculosis involving the lumbar spine and a sacroiliac joint: MR imaging findings. ( 16972219 )
2006
43
The use of real-time polymerase chain reaction for rapid diagnosis of skeletal tuberculosis. ( 16831035 )
2006
44
Multifocal skeletal tuberculosis with Rhodotorula minuta co-infection. ( 16718937 )
2006
45
Skeletal tuberculosis following fracture fixation. A report of five cases. ( 16651586 )
2006
46
Multifocal skeletal tuberculosis. ( 15352679 )
2004
47
Skeletal tuberculosis mimicking seronegative spondyloarthropathy. ( 12783178 )
2004
48
Skeletal tuberculosis in children. ( 15278319 )
2004
49
Multicentric skeletal tuberculosis in the absence of pulmonary disease. ( 15249833 )
2004
50
Multifocal skeletal tuberculosis in children: a retrospective study of 18 cases. ( 14723352 )
2003

Variations for Skeletal Tuberculosis

Expression for Skeletal Tuberculosis

Search GEO for disease gene expression data for Skeletal Tuberculosis.

Pathways for Skeletal Tuberculosis

GO Terms for Skeletal Tuberculosis

Cellular components related to Skeletal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.28 AMELX CFP CP CRP F9 FLNA
2 endoplasmic reticulum lumen GO:0005788 9.26 AMELX CFP CP F9

Biological processes related to Skeletal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction assembly GO:0034329 8.96 ACTB FLNA
2 tooth mineralization GO:0034505 8.62 AMELX AMELY

Molecular functions related to Skeletal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of tooth enamel GO:0030345 8.62 AMELX AMELY

Sources for Skeletal Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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