MCID: SKN001
MIFTS: 30

Skin Angiosarcoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Skin Angiosarcoma

MalaCards integrated aliases for Skin Angiosarcoma:

Name: Skin Angiosarcoma 12 15 70
Hemangiosarcoma of the Skin 12
Angiosarcoma of Skin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4517
NCIt 50 C4489
SNOMED-CT 67 254794007
UMLS 70 C0346081

Summaries for Skin Angiosarcoma

Disease Ontology : 12 An angiosarcoma and hemangioma of skin and malignant skin vascular tumor and sarcoma of skin that is located in the skin and results in an enlarged bruise (a blue-black nodule) and an unhealed ulceration.

MalaCards based summary : Skin Angiosarcoma, also known as hemangiosarcoma of the skin, is related to angiosarcoma and hereditary lymphedema i. An important gene associated with Skin Angiosarcoma is SNRK (SNF Related Kinase), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and G-protein signaling RAC1 in cellular process. The drugs Paclitaxel and Talimogene laherparepvec have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and breast, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Skin Angiosarcoma

Diseases related to Skin Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 29.2 TIE1 PTPRB FLT4
2 hereditary lymphedema i 9.9
3 basal cell carcinoma 9.9
4 vascular cancer 9.9 PTPRB FLT4
5 rare tumor 9.8
6 breast sarcoma 9.8 TIE1 SNRK
7 hennekam syndrome 9.8 FLT4 EPHB4
8 cardiovascular organ benign neoplasm 9.7 FLT4 EPHB4
9 breast angiosarcoma 9.5 TIE1 SNRK FLT4
10 lymphangiosarcoma 9.5 TIE1 SNRK FLT4
11 arteriovenous malformation 9.4 TIE1 EPHB4

Graphical network of the top 20 diseases related to Skin Angiosarcoma:



Diseases related to Skin Angiosarcoma

Symptoms & Phenotypes for Skin Angiosarcoma

GenomeRNAi Phenotypes related to Skin Angiosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.77 EPHB4 SNRK TIE1
2 Decreased viability GR00221-A-2 9.77 EPHB4 FLT4 SNRK
3 Decreased viability GR00221-A-4 9.77 EPHB4 TIE1
4 Decreased viability GR00249-S 9.77 SNRK
5 Decreased viability GR00301-A 9.77 EPHB4
6 Decreased viability GR00342-S-1 9.77 FLT4 TIE1
7 Decreased viability GR00342-S-2 9.77 FLT4 TIE1
8 Decreased viability GR00342-S-3 9.77 FLT4 TIE1
9 Decreased viability GR00386-A-1 9.77 FLT4
10 Decreased viability GR00402-S-2 9.77 EPHB4 SNRK

MGI Mouse Phenotypes related to Skin Angiosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 EPHB4 FLT4 PTPRB SNRK SULT1E1 TIE1
2 embryo MP:0005380 9.43 EPHB4 FLII FLT4 PTPRB SULT1E1 TIE1
3 muscle MP:0005369 9.02 EPHB4 FLT4 PTPRB SNRK TIE1

Drugs & Therapeutics for Skin Angiosarcoma

Drugs for Skin Angiosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
3
nivolumab Approved Phase 2 946414-94-4
4 Antimitotic Agents Phase 2
5 Albumin-Bound Paclitaxel Phase 2
6 Tubulin Modulators Phase 2
7 taxane Phase 2
8 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Pilot Study of Oraxol in Subjects With Cutaneous Angiosarcoma Recruiting NCT03544567 Phase 2 Oraxol
2 A Phase II Study of Talimogene Laherparepvec (T-VEC) in the Treatment of Locally Advanced Cutaneous Angiosarcoma Recruiting NCT03921073 Phase 2 T-VEC
3 A Multicenter Phase II Trial of Paclitaxel With and Without Nivolumab in Taxane Naive, and Nivolumab and Cabozantinib in Taxane Pretreated Subjects With Angiosarcoma Recruiting NCT04339738 Phase 2 Cabozantinib S-malate;Paclitaxel

Search NIH Clinical Center for Skin Angiosarcoma

Genetic Tests for Skin Angiosarcoma

Anatomical Context for Skin Angiosarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Skin Angiosarcoma:

19
Skin

MalaCards organs/tissues related to Skin Angiosarcoma:

40
Skin, Liver, Breast

Publications for Skin Angiosarcoma

Articles related to Skin Angiosarcoma:

# Title Authors PMID Year
1
Stewart-Treves syndrome: Case report and literature review. 61
33088229 2020
2
Angiosarcoma in Collision With a Merkel Cell Carcinoma: Case Report and Literature Review. 61
31601140 2020
3
Apatinib, combined with chemotherapy or alone is effective in treating angiosarcoma: a case report. 61
31305298 2019
4
Primary diagnosis of angiosarcoma by fine needle aspiration: Lessons learned from 3 cases. 61
29087044 2018
5
Cutaneous angiosarcoma: report of three different and typical cases admitted in a unique dermatology clinic. 61
28538886 2017
6
Primary scalp angiosarcoma with metastasis to the liver in an orthotopic liver transplant patient. 61
24410461 2014
7
Skin angiosarcoma arising in an irradiated breast: case-report and literature review. 61
16640696 2006
8
[Cutaneous angiosarcoma of the breast following surgery and irradiation of breast adenocarcinoma]. 61
3624820 1987
9
[Hemangiosarcoma of the skin--a clinicopathological study of 14 cases]. 61
3927038 1985
10
Malignant tumour of skin--angiosarcoma. 61
7197263 1981

Variations for Skin Angiosarcoma

Expression for Skin Angiosarcoma

Search GEO for disease gene expression data for Skin Angiosarcoma.

Pathways for Skin Angiosarcoma

Pathways related to Skin Angiosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.17 TIE1 FLT4 EPHB4
2
Show member pathways
11.43 TIE1 FLT4 EPHB4
3 10.97 TIE1 FLT4 EPHB4
4 10.34 TIE1 FLT4 EPHB4

GO Terms for Skin Angiosarcoma

Cellular components related to Skin Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.26 TIE1 PTPRB FLT4 EPHB4
2 receptor complex GO:0043235 8.92 TIE1 PTPRB FLT4 EPHB4

Biological processes related to Skin Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.71 TIE1 FLT4 FLII EPHB4
2 phosphorylation GO:0016310 9.67 TIE1 SNRK FLT4 EPHB4
3 protein phosphorylation GO:0006468 9.62 TIE1 SNRK FLT4 EPHB4
4 peptidyl-tyrosine phosphorylation GO:0018108 9.43 TIE1 FLT4 EPHB4
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.33 TIE1 FLT4 EPHB4
6 positive regulation of kinase activity GO:0033674 9.13 TIE1 FLT4 EPHB4
7 angiogenesis GO:0001525 8.92 TIE1 PTPRB FLT4 EPHB4

Molecular functions related to Skin Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.72 TIE1 SULT1E1 SNRK FLT4 EPHB4
2 kinase activity GO:0016301 9.56 TIE1 SNRK FLT4 EPHB4
3 protein kinase activity GO:0004672 9.46 TIE1 SNRK FLT4 EPHB4
4 protein tyrosine kinase activity GO:0004713 9.13 TIE1 FLT4 EPHB4
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 TIE1 FLT4 EPHB4

Sources for Skin Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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