Skin Atrophy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SKN005 MIFTS: 42	Skin Atrophy Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Skin Atrophy

MalaCards integrated aliases for Skin Atrophy:

Name: Skin Atrophy ¹² ¹⁵ ¹⁷

Atrophic Condition of Skin ¹² ⁷⁴

Atrophoderma ¹² ⁷⁷

Atrophy - Skin ¹²

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the skin and subcutaneous tissue

Other disorders of the skin and subcutaneous tissue

Atrophic disorders of skin

Atrophic disorder of skin, unspecified

External Ids:

Disease Ontology ¹² DOID:2733

NCIt ⁵¹ C35163

SNOMED-CT ⁶⁹ 16343004

ICD10 ³⁴ L90 L90.9

EFO ¹⁷ EFO_1000766

UMLS ⁷⁴ C0151514

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Summaries for Skin Atrophy

MalaCards based summary : Skin Atrophy, also known as atrophic condition of skin, is related to kindler syndrome and atrophoderma of pierini and pasini. An important gene associated with Skin Atrophy is FERMT1 (Fermitin Family Member 1), and among its related pathways/superpathways are Bladder cancer and Adhesion. The drugs mometasone furoate and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related phenotypes are growth/size/body region and immune system

Wikipedia : ⁷⁷ Atrophoderma refers to conditions involving skin... more...

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Related Diseases for Skin Atrophy

Diseases related to Skin Atrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)

#	Related Disease	Score	Top Affiliating Genes
1	kindler syndrome	31.4	FBLIM1 FERMT1
2	atrophoderma of pierini and pasini	12.6
3	atrophoderma vermiculata	12.6
4	bazex syndrome	12.2
5	follicular atrophoderma, perioral pigmented, with milia and epidermoid cysts	12.1
6	ichthyosis, congenital, autosomal recessive 11	11.5
7	flynn-aird syndrome	11.5
8	keratosis pilaris atrophicans	11.5
9	sequeiros sack syndrome	11.4
10	galloway-mowat syndrome 1	11.1
11	localized lipodystrophy	11.0
12	epidermolysis bullosa simplex, generalized, with scarring and hair loss	11.0
13	hallermann-streiff syndrome	10.9
14	rothmund-thomson syndrome	10.9
15	rombo syndrome	10.8
16	acrogeria, gottron type	10.8
17	cutis marmorata telangiectatica congenita	10.8
18	mandibuloacral dysplasia with type a lipodystrophy	10.8
19	atypical werner syndrome	10.8
20	hypotrichosis	10.4
21	localized scleroderma	10.3
22	ichthyosis	10.2
23	ichthyosis, follicular	10.2
24	cataract	10.0
25	ichthyosis lamellar 1	10.0
26	folliculitis	10.0
27	lichen sclerosus	10.0
28	warthin tumor	9.9	CD44 HBEGF
29	elastosis perforans serpiginosa	9.9
30	epidermoid cysts	9.9
31	lichen sclerosus et atrophicus	9.9
32	marfan syndrome	9.9
33	melkersson-rosenthal syndrome	9.9
34	nevus, epidermal	9.9
35	complement component 2 deficiency	9.9
36	xeroderma pigmentosum, variant type	9.9
37	basal cell carcinoma 1	9.9
38	arthritis	9.9
39	pseudoarthrosis	9.9
40	systemic scleroderma	9.9
41	loeys-dietz syndrome	9.9
42	acrodermatitis chronica atrophicans	9.9
43	keratosis	9.9
44	basal cell carcinoma	9.9
45	acrodermatitis	9.9
46	extramedullary plasmacytoma	9.9
47	plasmacytoma	9.9
48	hypertrichosis	9.9
49	pustulosis of palm and sole	9.9
50	connective tissue disease	9.9

Graphical network of the top 20 diseases related to Skin Atrophy:

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Symptoms & Phenotypes for Skin Atrophy

MGI Mouse Phenotypes related to Skin Atrophy:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.8	CD44 EBP FERMT1 GJA1 HBEGF KL
2	immune system	MP:0005387	9.7	CD44 FBLIM1 FERMT1 GJA1 KL MMP1
3	integument	MP:0010771	9.5	CD44 EBP FERMT1 GJA1 HBEGF KL
4	skeleton	MP:0005390	9.1	CD44 FBLIM1 GJA1 HBEGF KL MYSM1

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Drugs & Therapeutics for Skin Atrophy

Drugs for Skin Atrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

mometasone furoate

Approved, Investigational, Vet_approved

Phase 4

83919-23-7

Tacrolimus

Approved, Investigational

Phase 4

104987-11-3

445643 439492 6473866

Triamcinolone

Approved, Vet_approved

Phase 4,Not Applicable

124-94-7

31307

Pimecrolimus

Approved, Investigational

Phase 4

137071-32-0

17753757 6447131

Racepinephrine

Approved

Phase 4

329-65-7

838

Fluticasone

Approved, Experimental

Phase 4

90566-53-3

62924

Epinephrine

Approved, Vet_approved

Phase 4

51-43-4

5816

Fluocinolone Acetonide

Approved, Investigational, Vet_approved

Phase 4

67-73-2

6215

Hydroquinone

Approved, Investigational

Phase 4

123-31-9

785

Clobetasol

Approved, Experimental, Investigational

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

25122-46-7, 25122-41-2

32798 5311051

Betamethasone

Approved, Vet_approved

Phase 4,Phase 1

378-44-9

9782

Latanoprost

Approved, Investigational

Phase 4

130209-82-4

5311221 5282380

Coal tar

Approved

Phase 4

8007-45-2

Zinc

Approved, Investigational

Phase 4

7440-66-6

32051

Zinc oxide

Approved

Phase 4

1314-13-2

Tretinoin

Approved, Investigational, Nutraceutical

Phase 4,Not Applicable

302-79-4

5538 444795

Calcium

Approved, Nutraceutical

Phase 4,Phase 3

7440-70-2

271

Calcitriol

Approved, Nutraceutical

Phase 4,Phase 3

32222-06-3

134070 5280453

Anti-Allergic Agents

Phase 4

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Immunosuppressive Agents

Phase 4,Phase 1,Phase 2,Not Applicable

Immunologic Factors

Phase 4,Phase 1,Phase 2,Not Applicable

Dermatologic Agents

Phase 4,Phase 1,Not Applicable

Calcineurin Inhibitors

Phase 4

Peripheral Nervous System Agents

Phase 4,Phase 1,Not Applicable

glucocorticoids

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Hormones

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Triamcinolone hexacetonide

Phase 4,Not Applicable

Triamcinolone diacetate

Phase 4,Not Applicable

triamcinolone acetonide

Phase 4,Not Applicable

Pharmaceutical Solutions

Phase 4,Phase 1,Phase 2,Not Applicable

Analgesics, Non-Narcotic

Phase 4

Antirheumatic Agents

Phase 4

Analgesics

Phase 4

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Anti-Asthmatic Agents

Phase 4,Phase 1

Autonomic Agents

Phase 4,Phase 1

Respiratory System Agents

Phase 4,Phase 1

Bronchodilator Agents

Phase 4

Epinephryl borate

Phase 4

Radiation-Protective Agents

Phase 4

Protective Agents

Phase 4

Keratolytic Agents

Phase 4,Not Applicable

Antioxidants

Phase 4

Lidocaine, Prilocaine Drug Combination

Phase 4

Emollients

Phase 4,Phase 1

Betamethasone-17,21-dipropionate

Phase 4,Phase 1

Betamethasone sodium phosphate

Phase 4,Phase 1

Interventional clinical trials:

(show all 30)

#	Name	Status	NCT ID	Phase	Drugs
1	Comparison of Efficacy and Safety of 0.1% Tacrolimus and 0.1% Mometasone Furoate for Adult Vitiligo	Unknown status	NCT01333410	Phase 4	tacrolimus ointment;Mometasone furoate
2	Reconstitution With Pimecrolimus Cream 1% of Steroid-damaged Skin in Adults With Atopic Dermatitis	Completed	NCT00367393	Phase 4	Pimecrolimus cream 1%
3	Cutivate Lotion HPA Axis Pediatric Study	Completed	NCT00546000	Phase 4	Fluticasone propionate 0.05% lotion
4	Assessment of Atrophogenic Potential of Triple Combination Cream for Treatment of Melasma	Completed	NCT00469183	Phase 4	Fluocinolone acetonide .1%, hydroquinone 4%, tretinoin .05%
5	Comparison of Efficacy of Intralesional Triamcinolone Injection and Clobetasol Propionate Ointment for Psoriatic Nails	Completed	NCT01703325	Phase 4	0.1% triamcinolone , 0.05% clobetasol propionate ointment
6	Bilateral Comparison Study of Elidel 1% and Hylatopic Plus Emollient Foam for the Treatment of Subjects With Atopic Dermatitis	Completed	NCT01202149	Phase 4
7	Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata	Completed	NCT02350023	Phase 4	Topical latanoprost 0.005%;Topical betamethasone 0.05%
8	Safety and Efficacy of Pimecrolimus Cream 1% in Mild to Moderate Head and Neck Atopic Dermatitis (AD) Patients	Completed	NCT00121316	Phase 4	Pimecrolimus;Placebo
9	Efficacy/Safety/Subject Satisfaction/Duration of Response of Clobetasol Propionate Spray vs Ointment in Plaque Psoriasis	Completed	NCT00733954	Phase 4	clobetasol propionate spray;clobetasol propionate ointment
10	Evaluate Safety/Efficacy of Two Treatment Regimens for Vectical™ Ointment & Clobex® Spray for Moderate Plaque Psoriasis	Completed	NCT00988637	Phase 4	Vectical™ Ointment weekdays and Clobex® Spray weekends regimen;Clobex® Spray morning and Vectical™ Ointment evening regimen
11	Efficacy of Topical Coal Tar in Children With Atopic Dermatitis	Recruiting	NCT03461302	Phase 4	Topical coal tar;Topical corticosteroids
12	Intralesional Steroids in the Treatment of Alopecia Areata	Terminated	NCT01898806	Phase 4	Intralesional Triamcinolone 2.5 mg/ml;Intralesional Triamcinolone 5 mg/ml;Intralesional Triamcinolone 10 mg/ml;Intralesional Saline
13	Efficacy and Safety of 0.25% Desoximetasone Cream (Topoxy®) in the Treatment of Scalp Psoriasis	Unknown status	NCT02749656	Phase 3	0.25% Desoximetasone cream (Topoxy®);0.25% Desoximetasone cream (Topicorte®);Placebo
14	Safety & Effectiveness of Clobex Spray, Followed by Calcitriol Ointment in Management of Plaque Psoriasis	Completed	NCT00658788	Phase 3	clobetasol propionate spray 0.05%;calcitriol ointment
15	A Study to Evaluate the Safety and Efficacy of CB-03-01 Cream, 1% in Subjects With Facial Acne Vulgaris (26)	Completed	NCT02608476	Phase 3	CB-03-01 cream, 1%;Vehicle cream
16	A Study to Evaluate the Safety and Efficacy of CB-03-01 Cream, 1% in Subjects With Facial Acne Vulgaris (25)	Completed	NCT02608450	Phase 3	CB-03-01 cream, 1%;Vehicle cream
17	A Phase 2 Dose Ranging, Evaluator-Blinded Study to Evaluate the Safety of Topical IDP-118	Unknown status	NCT01670513	Phase 1, Phase 2	IDP-118 Low Strength;IDP-118 High Strength
18	Efficacy, Tolerability and Safety of LAS41004 Formulations in a Psoriasis Plaque Test	Completed	NCT02111499	Phase 1, Phase 2	LAS41004-IMP1;LAS41004 IMP2;LAS41004 IMP3;LAS41004 IMP4;LAS41004 IMP6;LAS41004 IMP5
19	Novel Compositions for Treating or Preventing Dermal Disorders	Recruiting	NCT03103893	Phase 1, Phase 2	Rapamycin
20	Clobetasol Topical Oil for Children With Moderate to Severe Atopic Dermatitis	Not yet recruiting	NCT03847389	Phase 1, Phase 2	Clobetasol propionate 0.05% Topical Oil
21	A Single-Centre Clinical Trial to Assess Steroid Induced Skin Atrophy on Healthy Skin	Completed	NCT02355639	Phase 1	Clobetasol propionate 0.05 % ointment;Betamethasone dipropionate 0.064 % ointment;Petrolatum ointment
22	A Clinical Trial to Assess the Potential of LEO 130852A Gel to Reduce Steroid Induced Skin Atrophy on Healthy Skin	Completed	NCT02392130	Phase 1	Clobetasol propionate 0.05% ointment;LEO 130852A gel 1%;LEO 130852A placebo gel
23	A Study Assessing GW870086's Potential to Cause Skin Thinning	Completed	NCT01381445	Phase 1	GW870086 0.2%;GW870086 2%;Clobetasol Propionate;Placebo
24	Olaparib and Radiotherapy in Head and Neck Cancer	Recruiting	NCT02229656	Phase 1	Olaparib
25	Study With a Topical Gel Containing TRIAC and DHEA in Subjects With Skin Atrophy Due to Glucocorticoids	Not yet recruiting	NCT03783988	Phase 1
26	Nonneoplastic Epithelial Disorders of Vulva and High Intensity Focused Ultrasound	Unknown status	NCT02890277	Not Applicable	Fu Tiankang disposable vaginal filling suppository, Albothyl (Policresulen Solution) , and the gynecologic medical antimicrobial dressing gel (chitosan gel).
27	The Comparison Study of Intralesional Botulinum Toxin A and Corticosteroid Injection for Alopecia Areata	Unknown status	NCT00999869	Not Applicable	Botulinum toxin type A;Triamcinolone acetonide
28	Comparison of Redermic, Rejuva-A and Combination of Both Redermic and Rejuva-A in Subjects With Signs of Aging	Completed	NCT00974480	Not Applicable	Tretinoin (Rejuva-A)
29	Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser	Completed	NCT02416531	Not Applicable	Clobetasol propionate
30	Broad Band Light With and Without Radiofrequency Microneedling for Treating Senile Purpura	Active, not recruiting	NCT03690375	Not Applicable

Search NIH Clinical Center for Skin Atrophy

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Genetic Tests for Skin Atrophy

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Anatomical Context for Skin Atrophy

MalaCards organs/tissues related to Skin Atrophy:

⁴²

Skin, Testes, Bone, Thyroid, Tongue

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Publications for Skin Atrophy

Articles related to Skin Atrophy:

(show top 50) (show all 58)

#	Title	Authors	Year
1	PI3K inhibitors protect against glucocorticoid-induced skin atrophy. ( 30737086 )	Agarwal S...Budunova I	2019
2	Syringaresinol Reverses Age-Related Skin Atrophy by Suppressing FoxO3a-Mediated Matrix Metalloproteinase-2 Activation in Copper/Zinc Superoxide Dismutase-Deficient Mice. ( 30798853 )	Kim J...Shimizu T	2019
3	Mineralocorticoid receptor blockade improves glucocorticoid-induced skin atrophy but partially ameliorates anti-inflammatory actions in an irritative model in human skin explants. ( 29178328 )	Boix J....PAcrez P.	2018
4	New features of aplasia cutis congenita type 5 - Skin atrophy associated with respiratory insufficiency and multiple intestinal atresia caused by the early death of twin fetus. ( 30316734 )	Sobczak A...Kwinta P	2018
5	Deletion of the glucocorticoid receptor chaperone FKBP51 prevents glucocorticoid-induced skin atrophy. ( 30410676 )	Baida G...Budunova I	2018
6	Chaperoning skin atrophy. ( 30559924 )	DeFranco DB	2018
7	Annular Plaques With Skin Atrophy in a Young Patient. ( 28122082 )	Zhou E.Y....Lin Z.	2017
8	Intralesional Treatment With 5-Fluorouracil and Steroid Improves Allergic Contact Dermatitis Without Causing Skin Atrophy and Rebound Lesions. ( 28338541 )	Chen X....Li T.	2017
9	Surgical Answer to Intralesional Steroid-Induced Skin Atrophy. ( 27870650 )	Ashique K.T....Kaliyadan F.	2016
10	Resveratrol Derivative-Rich Melinjo Seed Extract Attenuates Skin Atrophy in Sod1-Deficient Mice. ( 26180586 )	Watanabe K....Shimizu T.	2015
11	Acral skin atrophy in an infant: an early clue to Kindler syndrome diagnosis. ( 25764106 )	Diociaiuti A....El Hachem M.	2015
12	Topical corticosteroid-induced skin atrophy: a comprehensive review. ( 25862024 )	Barnes L....Rollason V.	2015
13	Palladium and Platinum Nanoparticles Attenuate Aging-Like Skin Atrophy via Antioxidant Activity in Mice. ( 25333617 )	Shibuya S....Shimizu T.	2014
14	Validation of Dermaphot(Ar) for the assessment of steroid-induced skin atrophy. ( 24488534 )	Thaci D.	2014
15	Calcipotriol counteracts betamethasone-induced decrease in extracellular matrix components related to skin atrophy. ( 25027750 )	Norsgaard H....pke M.	2014
16	Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice. ( 25229861 )	Shibuya S....Shimizu T.	2014
17	Hyalurosome gene regulation and dose-dependent restoration of skin atrophy by retinaldehyde and defined-size hyaluronate fragments in dermatoporosis. ( 25138066 )	Nikolic D.S....Kaya G.	2014
18	Validation of Dermaphot(Ar) for the assessment of steroid-induced skin atrophy. ( 23242470 )	Hofmann M....Thaci D.	2013
19	Topical corticosteroids in plaque psoriasis: a systematic review of risk of adrenal axis suppression and skin atrophy. ( 22512680 )	Castela E....Ortonne J.P.	2012
20	Vulvar skin atrophy induced by topical glucocorticoids. ( 22594868 )	Johnson E....Zolnoun D.	2012
21	Fluorescence spectroscopy as a tool to detect and evaluate glucocorticoid-induced skin atrophy. ( 22249456 )	Lemos M.C....Melo D.G.	2012
22	Linear skin atrophy preceding calcinosis cutis in pseudo-pseudohypoparathyroidism. ( 22299648 )	Lau K....Hoeger P.H.	2012
23	Shortened treatment duration of glucocorticoid-induced skin atrophy in rats. ( 21824195 )	Schoepe S....RAPse L.	2011
24	Test systems for the determination of glucocorticoid receptor ligand induced skin atrophy. ( 22110776 )	Schoepe S....Asadullah K.	2011
25	Evaluation of skin atrophy associated with linear atrophoderma of Moulin by ultrasound imaging. ( 21679833 )	Norisugi O....Shimizu T.	2011
26	Identification of novel in vitro test systems for the determination of glucocorticoid receptor ligand-induced skin atrophy. ( 20051715 )	Schoepe S....Asadullah K.	2010
27	A histological examination for skin atrophy after 6 months of treatment with fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% cream. ( 19755910 )	Bhawan J....Gottschalk R.	2009
28	Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. ( 19289104 )	Murakami K....Shimizu T.	2009
29	Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. ( 19057668 )	Ussar S....FAossler R.	2008
30	In vivo determination of the skin atrophy potential of the super-high-potency topical corticosteroid fluocinonide 0.1% cream compared with clobetasol propionate 0.05% cream and foam, and a vehicle. ( 18246695 )	Gans E.H....Kligman A.M.	2008
31	Action of topical thyroid hormone analogue, triiodothyroacetic acid in reversing glucocorticoid-induced skin atrophy in humans. ( 17123343 )	Yazdanparast P....Faergemann J.	2006
32	Glucocorticoid therapy-induced skin atrophy. ( 16689857 )	Schoepe S....Asadullah K.	2006
33	Skin atrophy caused by thiocolchicoside injections. ( 17184273 )	Guarneri F....CannavA^ S.P.	2006
34	Action of topical thyroid hormone analogues on glucocorticoid-induced skin atrophy in mice. ( 16571090 )	Yazdanparast P....Faergemann J.	2006
35	Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism. ( 17177600 )	Kaya G....Saurat J.H.	2006
36	Dose-response effects of tri-iodothyroacetic acid (Triac) and other thyroid hormone analogues on glucocorticoid-induced skin atrophy in the haired mouse. ( 12353707 )	Faergemann J....Sun X.Y.	2002
37	Topical tacrolimus and pimecrolimus are not associated with skin atrophy. ( 11903264 )	Bos J.D.	2002
38	Eyelid skin atrophy associated with chronic usage of ophthalmic steroid ointment, and its successful treatment with the Versapulse laser. ( 11702982 )	Phua V.M....Hakin K.N.	2001
39	The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. ( 11260007 )	Queille-Roussel C....Ortonne J.P.	2001
40	Comparison of skin atrophy and vasoconstriction due to mometasone furoate, methylprednisolone and hydrocortisone. ( 9553910 )	Hoffmann K....Altmeyer P.	1998
41	The molecular basis of glucocorticoid-induced skin atrophy: topical glucocorticoid apparently decreases both collagen synthesis and the corresponding collagen mRNA level in human skin in vivo. ( 9990383 )	Oikarinen A....Tasanen K.	1998
42	Skin atrophy of the eyelid induced by topical ophthalmic corticosteroids. ( 9686858 )	NeittaanmAoki H....Kallioinen M.	1998
43	Skin atrophy induced by initial continuous topical application of clobetasol followed by intermittent application. ( 7894098 )	Lubach D....Kietzmann M.	1995
44	In vivo prevention of corticosteroid-induced skin atrophy by tretinoin in the hairless mouse is accompanied by modulation of collagen, glycosaminoglycans, and fibronectin. ( 8106754 )	Schwartz E....Kligman L.H.	1994
45	Combination of a dual 5-lipoxygenase/cyclooxygenase inhibitor with a glucocorticoid results in synergistic topical antiinflammatory activity without inducing skin atrophy. ( 8225561 )	Tramposch K.M.	1993
46	Morphometric computerized analysis as a method to assess skin atrophy caused by corticosteroids. ( 8489771 )	Pelfini C....Calligaro A.	1993
47	0.25% prednicarbate cream and the corresponding vehicle induce less skin atrophy than 0.1% betamethasone-17-valerate cream and 0.05% clobetasol-17-propionate cream. ( 1618247 )	Korting H.C....Kerscher M.	1992
48	Topical all-trans-retinoic acid prevents corticosteroid-induced skin atrophy without abrogating the anti-inflammatory effect. ( 2768567 )	Lesnik R.H....Kligman L.H.	1989
49	Remote skin atrophy caused by topical steroids. ( 21253139 )	Griffiths D.E.	1988
50	Infection and prematurity as the cause of linear skin atrophy, alopecia, anonychia, and tongue lesions? ( 3901928 )	Sequeiros J....Sack G.H.	1985

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Genes for Skin Atrophy

Genes related to Skin Atrophy (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FERMT1	Fermitin Family Member 1	Protein Coding	32.77	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
2	KL	Klotho	Protein Coding	24.29	DISEASES inferred ¹⁵ GeneCards inferred via : Summaries (show sections)
3	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	21.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	CD44	CD44 Molecule (Indian Blood Group)	Protein Coding	20.54	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	GJA1	Gap Junction Protein Alpha 1	Protein Coding	17.28	GeneCards inferred via : Disorders (show sections)
6	MMP1	Matrix Metallopeptidase 1	Protein Coding	16.79	GeneCards inferred via : Publications (show sections)
7	EBP	EBP Cholestenol Delta-Isomerase	Protein Coding	16.23	DISEASES inferred ¹⁵
8	MBTPS2	Membrane Bound Transcription Factor Peptidase, Site 2	Protein Coding	16.07	DISEASES inferred ¹⁵
9	FBLIM1	Filamin Binding LIM Protein 1	Protein Coding	15.72	DISEASES inferred ¹⁵
10	MYSM1	Myb Like, SWIRM And MPN Domains 1	Protein Coding	15.7	DISEASES inferred ¹⁵

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Variations for Skin Atrophy

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Expression for Skin Atrophy

Search GEO for disease gene expression data for Skin Atrophy.

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Pathways for Skin Atrophy

Pathways related to Skin Atrophy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Bladder cancer ³⁸ ¹	11.23	HBEGF MMP1
2	Adhesion ⁴	11.22	CD44 FERMT1 GJA1
3	Hepatitis C and Hepatocellular Carcinoma ¹	11.03	CD44 MMP1
4	Cell adhesion_Cell-matrix glycoconjugates ²³	10.85	CD44 MMP1
5	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ¹	10.69	GJA1 MMP1
6	Cell adhesion_ECM remodeling ²³	10.58	CD44 HBEGF MMP1

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GO Terms for Skin Atrophy

Cellular components related to Skin Atrophy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.35	CD44 EBP GJA1 HBEGF KL
2	apical plasma membrane	GO:0016324	9.33	CD44 GJA1 KL
3	focal adhesion	GO:0005925	8.92	CD44 FBLIM1 FERMT1 GJA1

Biological processes related to Skin Atrophy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix disassembly	GO:0022617	8.96	CD44 MMP1
2	regulation of heart contraction	GO:0008016	8.62	GJA1 HBEGF

Molecular functions related to Skin Atrophy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	8.96	HBEGF KL
2	metallopeptidase activity	GO:0008237	8.8	MBTPS2 MMP1 MYSM1

Sources

Sources for Skin Atrophy

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

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⁶⁶ R&D Systems

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⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia