MCID: SKN005
MIFTS: 40

Skin Atrophy

Categories: Skin diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Skin Atrophy

MalaCards integrated aliases for Skin Atrophy:

Name: Skin Atrophy 11 14 16 75
Atrophic Condition of Skin 11 71
Atrophoderma 11 75
Atrophy - Skin 11

Classifications:



External Ids:

Disease Ontology 11 DOID:2733
NCIt 49 C35163
SNOMED-CT 68 16343004
ICD10 31 L90
UMLS 71 C0151514

Summaries for Skin Atrophy

MalaCards based summary: Skin Atrophy, also known as atrophic condition of skin, is related to hallermann-streiff syndrome and mandibuloacral dysplasia with type a lipodystrophy. An important gene associated with Skin Atrophy is FERMT1 (FERM Domain Containing Kindlin 1), and among its related pathways/superpathways are DNA Damage and AP-1 transcription factor network. The drugs Cathine and Guaifenesin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and tongue, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia: 75 Atrophoderma refers to conditions involving skin... more...

Related Diseases for Skin Atrophy

Diseases related to Skin Atrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 hallermann-streiff syndrome 31.8 ZMPSTE24 GJA1
2 mandibuloacral dysplasia with type a lipodystrophy 31.8 ZMPSTE24 LMNA
3 rothmund-thomson syndrome, type 2 31.7 WRN RECQL4 H2AC18 ERCC6
4 baller-gerold syndrome 31.7 WRN RECQL4 ERCC6
5 werner syndrome 31.4 WRN RECQL4 LMNA
6 telangiectasis 30.3 RECQL4 H2AC18 ERCC6
7 keratosis 30.2 LORICRIN LMNA GJA1 FLG
8 ichthyosis 30.0 LORICRIN GJA1 FLG EBP
9 dermatitis 30.0 LORICRIN IL4 IL31 FLG
10 dermatitis, atopic 29.8 LORICRIN IL4 IL31 FLG
11 calcinosis 29.7 ZMPSTE24 LMNA KL FGF23
12 contact dermatitis 29.7 LORICRIN IL4 IL31 FLG
13 allergic contact dermatitis 29.7 LORICRIN IL4 IL31 FLG
14 cataract 29.5 WRN RECQL4 NR3C1 LMNA KL GJA1
15 skin disease 29.3 RECQL4 LORICRIN IL4 IL31 H2AC18 GJA1
16 atrophoderma of pasini and pierini 11.6
17 atrophoderma vermiculata 11.6
18 bazex syndrome 11.5
19 ichthyosis, congenital, autosomal recessive 11 11.4
20 rombo syndrome 11.4
21 flynn-aird syndrome 11.3
22 keratosis pilaris atrophicans 11.2
23 kindler syndrome 11.1
24 epidermolysis bullosa simplex 6, generalized, with scarring and hair loss 11.1
25 galloway-mowat syndrome 1 11.0
26 x-linked chondrodysplasia punctata 2 11.0
27 xeroderma pigmentosum, variant type 11.0
28 follicular atrophoderma, perioral pigmented, with milia and epidermoid cysts 11.0
29 cutis marmorata telangiectatica congenita 10.8
30 neonatal scleroderma 10.8
31 localized scleroderma 10.4
32 conjunctival deposit 10.3 KL FGF23
33 basal cell carcinoma 10.3
34 rapadilino syndrome 10.3 WRN RECQL4 ERCC6
35 dental abscess 10.3 KL FGF23
36 occupational dermatitis 10.3 IL31 FLG
37 mineral metabolism disease 10.3 KL H2AC18 FGF23
38 hypervitaminosis d 10.2 TRPV5 KL FGF23
39 autosomal recessive cerebellar ataxia 10.2 WRN H2AC18 ERCC6
40 restrictive dermopathy 1 10.2 ZMPSTE24 LMNA
41 cicatricial lagophthalmos 10.2 LORICRIN FLG
42 restrictive dermopathy 10.2 ZMPSTE24 LMNA
43 phosphorus metabolism disease 10.2 TRPV5 KL FGF23
44 bone development disease 10.2 RECQL4 H2AC18 ERCC6
45 hyperostosis 10.2 KL GJA1 FGF23
46 parathyroid gland disease 10.2 TRPV5 KL FGF23
47 lethal restrictive dermopathy 10.2 ZMPSTE24 LMNA
48 lipodystrophy, familial partial, type 1 10.2 ZMPSTE24 LMNA
49 photoparoxysmal response 1 10.2 FERMT1 ERCC6
50 acroosteolysis 10.2 ZMPSTE24 LMNA

Graphical network of the top 20 diseases related to Skin Atrophy:



Diseases related to Skin Atrophy

Symptoms & Phenotypes for Skin Atrophy

MGI Mouse Phenotypes related to Skin Atrophy:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.37 EBP ERCC6 FERMT1 FGF23 GJA1 IL4
2 homeostasis/metabolism MP:0005376 10.36 DDIT4 ERCC6 FERMT1 FGF23 GJA1 IL4
3 cellular MP:0005384 10.25 ACTRT1 DDIT4 ERCC6 FERMT1 GJA1 IL4
4 endocrine/exocrine gland MP:0005379 10.22 FGF23 GJA1 IL4 KL LMNA LORICRIN
5 renal/urinary system MP:0005367 10.21 FERMT1 FGF23 IL4 KL LMNA LORICRIN
6 immune system MP:0005387 10.21 ERCC6 FERMT1 FGF23 GJA1 IL4 KL
7 limbs/digits/tail MP:0005371 10.19 ERCC6 FGF23 GJA1 IL31 KL LMNA
8 digestive/alimentary MP:0005381 10.16 FERMT1 FGF23 IL4 KL LMNA NR3C1
9 liver/biliary system MP:0005370 10.15 ERCC6 IL4 KL LMNA LORICRIN NR3C1
10 adipose tissue MP:0005375 10.07 ERCC6 KL LMNA NR3C1 TSC22D3 WRN
11 reproductive system MP:0005389 10.06 ACTRT1 DDIT4 FGF23 GJA1 IL4 KL
12 skeleton MP:0005390 10.03 ERCC6 FGF23 GJA1 IL31 IL4 KL
13 hematopoietic system MP:0005397 10 EBP ERCC6 FGF23 GJA1 IL4 KL
14 craniofacial MP:0005382 9.98 GJA1 IL4 KL LMNA RECQL4 WRN
15 mortality/aging MP:0010768 9.8 DDIT4 EBP ERCC6 FERMT1 FGF23 GJA1
16 integument MP:0010771 9.44 EBP ERCC6 FERMT1 FGF23 GJA1 IL4

Drugs & Therapeutics for Skin Atrophy

Drugs for Skin Atrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cathine Approved, Experimental, Illicit, Vet_approved, Withdrawn Phase 1 14838-15-4, 492-39-7 131954576 4786 26934
2
Guaifenesin Approved, Investigational, Vet_approved Phase 1 93-14-1 3516
3
Clobetasol Approved, Experimental, Investigational Phase 1 25122-46-7, 25122-41-2 2791 5311051 32798
4
Betamethasone Approved, Vet_approved Phase 1 378-44-9 9782
5
Petrolatum Approved, Investigational Phase 1 8009-03-8
6
Prasterone Approved, Investigational, Nutraceutical Phase 1 53-43-0 5881
7 Chlorpheniramine, phenylpropanolamine drug combination Phase 1
8 DHEA (Dehydroepiandrosterone) Phase 1
9 glucocorticoids Phase 1
10 Hormones Phase 1
11 Hormone Antagonists Phase 1
12 Anti-Inflammatory Agents Phase 1
13 Anti-Asthmatic Agents Phase 1
14 Betamethasone-17,21-dipropionate Phase 1
15
Betamethasone Valerate Phase 1 2152-44-5
16
Betamethasone sodium phosphate Phase 1
17
Betamethasone benzoate Phase 1
18 Respiratory System Agents Phase 1
19 Emollients Phase 1
20 Dermatologic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Controlled, Observer-blind Psoriasis Plaque Test to Investigate the Anti-psoriatic Efficacy, Tolerability and Safety (Skin Atrophy) of LAS41004 Formulations in Patients With Mild to Moderate Plaque Psoriasis Completed NCT02111499 Phase 1, Phase 2 LAS41004-IMP1;LAS41004 IMP2;LAS41004 IMP3;LAS41004 IMP4;LAS41004 IMP6;LAS41004 IMP5
2 An Open, Uncontrolled Pharmacokinetic Study With a New Topical Combination Gel Containing Triiodothyroacetic Acid (TRIAC) and Dehydroepiandrosterone (DHEA) in Subjects With Skin Atrophy Due to Topical Treatment With Glucocorticoids Unknown status NCT03783988 Phase 1
3 A Prospective, Randomised, Investigator-Blinded, Vehicle-Controlled, Phase I Clinical Trial With Intra-Individual Comparison of Treatments to Assess the Potential of LEO 130852A Gel to Reduce Steroid Induced Skin Atrophy on Healthy Skin Completed NCT02392130 Phase 1 Clobetasol propionate 0.05% ointment;LEO 130852A gel 1%;LEO 130852A placebo gel
4 A Single-Centre, Explorative, Randomised, Investigator-Blinded, Negative-Controlled, Phase I Clinical Trial With Intra-Individual Comparison of Treatments to Assess Steroid Induced Skin Atrophy on Healthy Skin Completed NCT02355639 Phase 1 Clobetasol propionate 0.05 % ointment;Betamethasone dipropionate 0.064 % ointment;Petrolatum ointment

Search NIH Clinical Center for Skin Atrophy

Genetic Tests for Skin Atrophy

Anatomical Context for Skin Atrophy

Organs/tissues related to Skin Atrophy:

MalaCards : Skin, Breast, Tongue, Thyroid, Bone, Kidney, Liver

Publications for Skin Atrophy

Articles related to Skin Atrophy:

(show top 50) (show all 976)
# Title Authors PMID Year
1
Germline intergenic duplications at Xq26.1 underlie Bazex-Dupré-Christol basal cell carcinoma susceptibility syndrome. 62
35986704 2022
2
Rejuvenation of the ageing face and the role of orthodontics: Guidelines for management. 62
35437070 2022
3
Kaempferol tetrasaccharides restore skin atrophy via PDK1 inhibition in human skin cells and tissues: Bench and clinical studies. 62
36252351 2022
4
Efficacy of a triamcinolone acetonide-loaded dissolving microneedle patch for the treatment of hypertrophic scars and keloids: a randomized, double-blinded, placebo-controlled split-scar study. 62
36383222 2022
5
Conradi-Hünermann-Happle syndrome: Clinical and trichoscopic findings. 62
36263758 2022
6
Laser therapy for treating hypertrophic and keloid scars. 62
36161591 2022
7
From Morphea to Dermatofibrosarcoma Protuberans. 62
36254545 2022
8
Atypical Scleroderma-like Chronic GVHD in a Liver Transplant Patient, Clinical and MRI Correlations. 62
36254548 2022
9
A plant-derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy. 62
36165414 2022
10
Proteomic and miRNA profiling of radon-induced skin damage in mice: FASN regulated by miRNAs. 62
35791446 2022
11
Patient preferences for topical psoriasis treatments: a discrete choice experiment. 62
35373695 2022
12
Management of Atopic Dermatitis: The Role of Tacrolimus. 62
35990561 2022
13
Conradi-Hünermann-Happle syndrome associated with severe hypocalcemia in a newborn. 62
35355312 2022
14
Linear atrophoderma of Moulin is due to the decreased dermal thickness. 62
35687843 2022
15
The mineralocorticoid receptor in skin disease. 62
34788475 2022
16
Idiopathic Atrophoderma of Pasini and Pierini: A Case Report and Literature Review. 62
35936167 2022
17
Inhibitory Effect of Mitoxantrone on Collagen Synthesis in Dermal Fibroblasts. 62
35721328 2022
18
Isolated and Classic Cutis Marmorata Telangiectatica Congenita 62
35679444 2022
19
Preclinical Testing of Dendritic Core-Multishell Nanoparticles in Inflammatory Skin Equivalents. 62
35266720 2022
20
Blaschko-linear lichen planus of the face: A retrospective study of 6 cases and a literature review. 62
34538651 2022
21
Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review. 62
35708049 2022
22
Stellate Hypopigmentation in a Pediatric Patient After Treatment with Intralesionally-Injected Corticosteroid. 62
35724245 2022
23
Urological Manifestations of Kindler Syndrome: A Case Report. 62
35676982 2022
24
Halobetasol Propionate 0.01% Lotion for Plaque Psoriasis and Corticosteroid-Responsive Dermatoses. 62
35533304 2022
25
Adrenal carcinoma: a case report. 62
35637536 2022
26
Reliability of B-mode ultrasound and shear wave elastography in evaluating sacral bone and soft tissue characteristics in young adults with clinical feasibility in elderly. 62
35236613 2022
27
Dermoscopic and Reflectance Confocal Microscopy Features of Superficial Morphea on Preexisting Atrophoderma of Pasini and Pierini. 62
35646456 2022
28
Efficacy and safety of thermomechanical fractional injury-assisted corticosteroid delivery versus intralesional corticosteroid injection for the treatment of hypertrophic scars: A randomized split-scar trial. 62
34913497 2022
29
Evaluating topical JAK inhibitors as a treatment option for atopic dermatitis. 62
34637367 2022
30
Proactive vs. reactive psoriasis therapy: a long-term evaluation with dermoscopic and confocal microscopy assessment. 62
35363352 2022
31
Skin atrophy caused by topical glucocorticoids is less common in patients with atopic dermatitis than in those with psoriasis. 62
34351656 2022
32
Novel Dermal Delivery Cargos of Clobetasol Propionate: An Update. 62
35214115 2022
33
Two Cases of Paradoxical Nonscarring Alopecia after Mesotherapy with Dutasteride. 62
35118130 2022
34
Osilodrostat for Cushing disease and its role in pediatrics. 62
35045421 2022
35
Effects of Intermittent Treatment with Topical Corticosteroids and Calcineurin Inhibitors on Epidermal and Dermal Thickness Using Optical Coherence Tomography and Ultrasound. 62
34348352 2022
36
Treatment of a Chronic Vulvar Wound by Hyperbaric Oxygen Therapy (HBOT). 62
35070462 2022
37
Characterization of a novel non-steroidal glucocorticoid receptor agonist optimized for topical treatment. 62
35087193 2022
38
Linear atrophoderma of Moulin and atrophoderma of Pasini and Pierini: the relevance of ultrasound imaging in the initial assessment. 62
31104466 2021
39
Hyperpigmented lesions with acquired atrophy following Blaschko lines in a patient with diagnosed with localized scleroderma. 62
34594051 2021
40
Pencil Beam Scanning (PBS) Intensity-Modulated Proton Therapy (IMPT) Chemoradiotherapy for Anal Canal Cancer-Single Institution Experience. 62
35008349 2021
41
Novel use of poly-L-lactic acid filler for the treatment of facial cutaneous atrophy in patients with connective tissue disease. 62
34460983 2021
42
Porokeratosis of the Nail Unit: Case Series and Review. 62
34901183 2021
43
Topical steroid containing combinations: Burden of adverse effects and why the recent regulatory action may not be enough. 62
34854405 2021
44
Aesthetic and therapeutic outcome of fat grafting for localized Scleroderma treatment: From basic study to clinical application. 62
33486881 2021
45
Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients. 62
33550695 2021
46
The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis. 62
33814214 2021
47
Biorevitalization of the skin with skin boosters: Concepts, variables, and limitations. 62
33249741 2021
48
The use of high frequency skin ultrasound in non-melanoma skin cancer. 62
34484364 2021
49
Hydroxyurea: a reappraisal of its cutaneous side effects and their management. 62
33179784 2021
50
Mucocutaneous manifestations of patients with chronic kidney disease under hemodialysis: A cross-sectional study of 49 patients. 62
34080277 2021

Variations for Skin Atrophy

Expression for Skin Atrophy

Search GEO for disease gene expression data for Skin Atrophy.

Pathways for Skin Atrophy

Pathways related to Skin Atrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.93 WRN RECQL4 LMNA DDIT4
2 10.97 NR3C1 IL4 GJA1
3
Show member pathways
10.14 ZMPSTE24 WRN LMNA

GO Terms for Skin Atrophy

Biological processes related to Skin Atrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.96 ZMPSTE24 LMNA IL4 GJA1 FGF23 ERCC6
2 telomeric D-loop disassembly GO:0061820 9.62 WRN RECQL4
3 calcium ion homeostasis GO:0055074 9.43 TRPV5 KL FGF23
4 neuroinflammatory response GO:0150076 9.33 NR3C1 IL4
5 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 8.92 KL FGF23

Molecular functions related to Skin Atrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bubble DNA binding GO:0000405 9.46 WRN RECQL4
2 four-way junction helicase activity GO:0009378 9.26 WRN RECQL4
3 telomeric D-loop binding GO:0061821 8.92 WRN RECQL4

Sources for Skin Atrophy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....