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MCID: SKN005
MIFTS: 41

Skin Atrophy

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Skin Atrophy

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MalaCards integrated aliases for Skin Atrophy:

Name: Skin Atrophy 12 15 17
Atrophic Condition of Skin 12 70
Atrophoderma 12 73
Atrophy - Skin 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:2733
NCIt 50 C35163
SNOMED-CT 67 16343004
ICD10 32 L90
UMLS 70 C0151514
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Summaries for Skin Atrophy

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MalaCards based summary : Skin Atrophy, also known as atrophic condition of skin, is related to hallermann-streiff syndrome and rothmund-thomson syndrome, type 2. An important gene associated with Skin Atrophy is FERMT1 (FERM Domain Containing Kindlin 1), and among its related pathways/superpathways are DNA Damage and Adhesion. The drugs Guaifenesin and Phenylpropanolamine have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and kidney, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : 73 Atrophoderma refers to conditions involving skin... more...

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Related Diseases for Skin Atrophy

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Diseases related to Skin Atrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 hallermann-streiff syndrome 31.9 ZMPSTE24 GJA1
2 rothmund-thomson syndrome, type 2 31.8 WRN RECQL4 ERCC6
3 mandibuloacral dysplasia with type a lipodystrophy 31.6 ZMPSTE24 LMNA
4 werner syndrome 31.4 WRN RECQL4 LMNA
5 keratosis 30.3 LORICRIN GJA1 FLG
6 aging 29.8 WRN LMNA KL
7 calcinosis 29.6 ZMPSTE24 LMNA KL FGF23
8 skin disease 29.5 MMP1 LORICRIN LMNA HBEGF GJA1 FLG
9 cataract 29.4 WRN RECQL4 NR3C1 LMNA GJA1 ERCC6
10 skin carcinoma 29.3 MMP1 LORICRIN FLG ERCC6 CD44
11 bazex syndrome 11.6
12 atrophoderma vermiculata 11.6
13 atrophoderma of pasini and pierini 11.5
14 ichthyosis, congenital, autosomal recessive 11 11.4
15 rombo syndrome 11.3
16 flynn-aird syndrome 11.2
17 galloway-mowat syndrome 1 11.2
18 keratosis pilaris atrophicans 11.1
19 kindler syndrome 11.1
20 follicular atrophoderma, perioral pigmented, with milia and epidermoid cysts 10.9
21 x-linked chondrodysplasia punctata 2 10.9
22 epidermolysis bullosa simplex, generalized, with scarring and hair loss 10.9
23 localized lipodystrophy 10.9
24 buerger disease 10.8
25 baller-gerold syndrome 10.8
26 cutis marmorata telangiectatica congenita 10.8
27 atypical werner syndrome 10.8
28 localized scleroderma 10.4
29 conjunctival deposit 10.3 KL FGF23
30 tracheal calcification 10.3 KL FGF23
31 chronic actinic dermatitis 10.3 MMP1 FLG
32 nephrolithiasis/osteoporosis, hypophosphatemic, 1 10.3 KL FGF23
33 dental abscess 10.3 KL FGF23
34 epidermolysis bullosa pruriginosa 10.3 MMP1 FLG
35 hypophosphatemic rickets with hypercalciuria, hereditary 10.3 KL FGF23
36 hepatocellular clear cell carcinoma 10.3 KL FGF23
37 pseudoainhum 10.3 LORICRIN GJA1
38 epidermolysis bullosa dystrophica 10.2 MMP1 FLG FERMT1
39 hyperostosis 10.2 KL GJA1 FGF23
40 acroosteolysis 10.2 ZMPSTE24 LMNA
41 familial tumoral calcinosis 10.2 KL FGF23
42 acquired generalized lipodystrophy 10.2 ZMPSTE24 LMNA
43 xfe progeroid syndrome 10.2 WRN ERCC6
44 laminopathy 10.2 ZMPSTE24 LMNA
45 stomach carcinoma in situ 10.2 LORICRIN FLG
46 reynolds syndrome 10.2 ZMPSTE24 LMNA
47 hypervitaminosis d 10.2 TRPV5 KL FGF23
48 phosphorus metabolism disease 10.2 TRPV5 KL FGF23
49 dowling-degos disease 1 10.2
50 emery-dreifuss muscular dystrophy 3, autosomal recessive 10.2 ZMPSTE24 LMNA

Graphical network of the top 20 diseases related to Skin Atrophy:



Diseases related to Skin Atrophy
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Symptoms & Phenotypes for Skin Atrophy

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MGI Mouse Phenotypes related to Skin Atrophy:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.42 CD44 DDIT4 ERCC6 FERMT1 FGF23 GJA1
2 growth/size/body region MP:0005378 10.4 CD44 EBP ERCC6 FERMT1 FGF23 GJA1
3 cellular MP:0005384 10.37 CD44 DDIT4 ERCC6 FERMT1 GJA1 KL
4 hematopoietic system MP:0005397 10.32 CD44 EBP ERCC6 FGF23 GJA1 KL
5 immune system MP:0005387 10.32 CD44 ERCC6 FERMT1 FGF23 GJA1 KL
6 integument MP:0010771 10.3 CD44 EBP ERCC6 FERMT1 FGF23 GJA1
7 cardiovascular system MP:0005385 10.27 CD44 DDIT4 FGF23 GJA1 HBEGF KL
8 digestive/alimentary MP:0005381 10.25 CD44 FERMT1 FGF23 KL LMNA NR3C1
9 endocrine/exocrine gland MP:0005379 10.24 CD44 FGF23 GJA1 KL LMNA NR3C1
10 mortality/aging MP:0010768 10.21 CD44 DDIT4 EBP ERCC6 FERMT1 FGF23
11 adipose tissue MP:0005375 10.12 ERCC6 KL LMNA NR3C1 TSC22D3 WRN
12 limbs/digits/tail MP:0005371 10.09 CD44 ERCC6 FGF23 GJA1 KL LMNA
13 liver/biliary system MP:0005370 9.95 CD44 ERCC6 KL LMNA NR3C1 TSC22D3
14 muscle MP:0005369 9.92 CD44 ERCC6 GJA1 HBEGF KL LMNA
15 renal/urinary system MP:0005367 9.86 CD44 FERMT1 FGF23 KL LMNA NR3C1
16 reproductive system MP:0005389 9.81 CD44 DDIT4 FGF23 GJA1 KL LMNA
17 respiratory system MP:0005388 9.56 CD44 FGF23 GJA1 HBEGF HYAL3 KL
18 skeleton MP:0005390 9.4 CD44 ERCC6 FGF23 GJA1 HBEGF KL
Sources

Drugs & Therapeutics for Skin Atrophy

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Drugs for Skin Atrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guaifenesin Approved, Investigational, Vet_approved Phase 1 93-14-1 3516
2
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 1 14838-15-4 26934
3
Petrolatum Approved, Investigational Phase 1 8009-03-8
4
Clobetasol Approved, Experimental, Investigational Phase 1 25122-46-7, 25122-41-2 32798 5311051
5
Betamethasone Approved, Vet_approved Phase 1 378-44-9 9782
6
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 1 53-43-0 5881
7 Chlorpheniramine, phenylpropanolamine drug combination Phase 1
8 DHEA (Dehydroepiandrosterone) Phase 1
9 glucocorticoids Phase 1
10 Respiratory System Agents Phase 1
11 Anti-Asthmatic Agents Phase 1
12 Hormones Phase 1
13 Hormone Antagonists Phase 1
14 Emollients Phase 1
15 Betamethasone benzoate Phase 1
16 Betamethasone-17,21-dipropionate Phase 1
17 Anti-Inflammatory Agents Phase 1
18 Betamethasone sodium phosphate Phase 1
19 Dermatologic Agents Phase 1
20 Betamethasone Valerate Phase 1 2152-44-5

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Controlled, Observer-blind Psoriasis Plaque Test to Investigate the Anti-psoriatic Efficacy, Tolerability and Safety (Skin Atrophy) of LAS41004 Formulations in Patients With Mild to Moderate Plaque Psoriasis Completed NCT02111499 Phase 1, Phase 2 LAS41004-IMP1;LAS41004 IMP2;LAS41004 IMP3;LAS41004 IMP4;LAS41004 IMP6;LAS41004 IMP5
2 An Open, Uncontrolled Pharmacokinetic Study With a New Topical Combination Gel Containing Triiodothyroacetic Acid (TRIAC) and Dehydroepiandrosterone (DHEA) in Subjects With Skin Atrophy Due to Topical Treatment With Glucocorticoids Unknown status NCT03783988 Phase 1
3 A Single-Centre, Explorative, Randomised, Investigator-Blinded, Negative-Controlled, Phase I Clinical Trial With Intra-Individual Comparison of Treatments to Assess Steroid Induced Skin Atrophy on Healthy Skin Completed NCT02355639 Phase 1 Clobetasol propionate 0.05 % ointment;Betamethasone dipropionate 0.064 % ointment;Petrolatum ointment
4 A Prospective, Randomised, Investigator-Blinded, Vehicle-Controlled, Phase I Clinical Trial With Intra-Individual Comparison of Treatments to Assess the Potential of LEO 130852A Gel to Reduce Steroid Induced Skin Atrophy on Healthy Skin Completed NCT02392130 Phase 1 Clobetasol propionate 0.05% ointment;LEO 130852A gel 1%;LEO 130852A placebo gel
5 A Prospective, Randomized, Split-Arm Pilot Study Investigating the Efficacy and Safety of Sciton's Broad Band Light With and Without Cutera's Radiofrequency Microneedling for Improving the Clinical Signs of Senile Purpura Completed NCT03690375

Search NIH Clinical Center for Skin Atrophy

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Genetic Tests for Skin Atrophy

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Anatomical Context for Skin Atrophy

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MalaCards organs/tissues related to Skin Atrophy:

40
Skin, Tongue, Kidney, Eye, Testis, Thyroid, Breast
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Publications for Skin Atrophy

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Articles related to Skin Atrophy:

(show top 50) (show all 904)
# Title Authors PMID Year
1
Unmet medical needs in the treatment of atopic dermatitis in infants: An Expert consensus on safety and efficacy of pimecrolimus. 61
33251600 2021
2
A Severe Necrotizing Inflammatory Reaction of Leg Wounds Following Autologous Peripheral Blood Total Nucleated Cells Treatment in an Old Patient With Rheumatoid Arthritis and No-Option Chronic Limb-Threatening Ischemia: Is Cell Therapy Suitable for All Patients? 61
33719646 2021
3
Cold Atmospheric Plasma (CAP) for the Treatment of Actinic Keratosis and Skin Field Cancerization: Clinical and High-Frequency Ultrasound Evaluation. 61
33738749 2021
4
Stromal vascular fraction and emulsified fat as regenerative tools in rejuvenation of the lower eyelid area. 61
33704865 2021
5
Erosive pustular dermatosis in a patient with lichen planopilaris treated with aminolevulinic acid photodynamic therapy. 61
33556619 2021
6
Topical delivery of clobetasol propionate loaded nanosponge hydrogel for effective treatment of psoriasis: Formulation, physicochemical characterization, antipsoriatic potential and biochemical estimation. 61
33321649 2021
7
Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients. 61
33550695 2021
8
Practical Recommendations for the Topical Treatment of Atopic Dermatitis in South and East Asia. 61
33313998 2021
9
The Wound Healing Peptide, AES16-2M, Ameliorates Atopic Dermatitis In Vivo. 61
33671791 2021
10
Linear perioral atrophoderma along blaschko's lines- a retrospective study describing 14 cases of atrophia maculosa varioliformis cutis. 61
33125705 2021
11
Nevus comedonicus syndrome: A systematic review of the literature. 61
33481271 2021
12
Ultrasonography, MRI and classic radiography of skin and MSK involvement in juvenile scleroderma. 61
33500800 2021
13
Macrophage Migration Inhibitory Factor (MIF) and Its Homologue d-Dopachrome Tautomerase (DDT) Inversely Correlate with Inflammation in Discoid Lupus Erythematosus. 61
33401503 2021
14
Erosive pustular dermatosis of the scalp: causes and treatments. 61
32516510 2021
15
Triple treatment in ear keloids: Comparison of post-excisional intralesional steroid and platelet-rich plasma treatment. 61
33545451 2021
16
The use of dry needling vs. corticosteroid injection to treat lateral epicondylitis: a prospective, randomized, controlled study. 61
32950674 2021
17
Dermatologist Use of Intralesional Triamcinolone in the Treatment of Acne. 61
33488919 2020
18
Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti-inflammatory agent and as adjuvant in psoriasis therapy. 61
32846458 2020
19
Effects of Delgocitinib Ointment 0.5% on the Normal Mouse Skin and Epidermal Tight Junction Proteins in Comparison With Topical Corticosteroids. 61
33334258 2020
20
Comparing the Efficacy and Safety of Intralesional Verapamil With Intralesional Triamcinolone Acetonide in Treatment of Hypertrophic Scars and Keloids: A Meta-Analysis of Randomized Controlled Trials. 61
33313652 2020
21
Eczema in elderly people. 61
33258454 2020
22
Hydroxyurea: a reappraisal of its cutaneous side effects and their management. 61
33179784 2020
23
Kindler Syndrome: A Multidisciplinary Management Approach. 61
32861675 2020
24
A linear forehead lesion caused by intralesional injection of triamcinolone acetonide and treated with hyaluronic acid filler: Case report. 61
33174645 2020
25
Biorevitalization of the skin with skin boosters: Concepts, variables, and limitations. 61
33249741 2020
26
Biochemical and physical actions of hyaluronic acid delivered by intradermal jet injection route. 61
32799371 2020
27
Effects of Adipose-Derived Stem Cells and Platelet-Rich Plasma for Prevention of Alopecia and Other Skin Complications of Radiotherapy. 61
33141771 2020
28
Proton beam therapy combined with retrograde intra-arterial infusion chemotherapy for an extremely rapid growing recurrent ameloblastic carcinoma: A case report. 61
32802330 2020
29
Topical 'dual-soft' glucocorticoid receptor agonist for dermatology. 61
32738970 2020
30
Outcome of triamcinolone acetonide injection for lateral malleolar bursitis. 61
32873149 2020
31
Caffeoyl-Prolyl-Histidine Amide Inhibits Fyn and Alleviates Atopic Dermatitis-Like Phenotypes via Suppression of NF-κB Activation. 61
32998341 2020
32
Iatrogenic Anetoderma of Prematurity: A Series of 5 Clinical Cases and Literature Review. 61
32876031 2020
33
Erosive pustular dermatosis of the scalp. 61
32941728 2020
34
Linear atrophoderma of Moulin: dermal or subcutaneous atrophy? 61
32100290 2020
35
Efficacy and safety of verapamil vs triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis. 61
32400925 2020
36
Cutis marmorata telangiectatica congenita successfully treated with intense pulsed light and pulse dyed laser therapy: a case report. 61
33586582 2020
37
Prostaglandin-Associated Periorbitopathy in Children and Young Adults with Glaucoma. 61
33008561 2020
38
Unilateral generalized morphea: First case report in Taiwan. 61
30525738 2020
39
Multiple subcutaneous haematomas of the legs causing skin necrosis in an elderly patient affected by corticosteroid-induced skin atrophy: Case report and review of literature. 61
31972900 2020
40
Preclinical study of the topical anti-inflammatory activity of Cyperus rotundus L. extract (Cyperaceae) in models of skin inflammation. 61
32109543 2020
41
Pharmacological management of atopic dermatitis in the elderly. 61
32100586 2020
42
Linear Atrophoderma of Moulin. 61
32236506 2020
43
Corticoid-like anti-inflammatory effect of Vochysia bifalcata Warm.: Preclinical evidence of efficacy and safety. 61
31836516 2020
44
The Safety and Efficacy of Intralesional Verapamil Versus Intralesional Triamcinolone Acetonide for Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis. 61
32195728 2020
45
A novel pathogenic FERMT1 variant in four families with Kindler syndrome in Argentina. 61
31957900 2020
46
Long-term safety and efficacy of delgocitinib ointment, a topical Janus kinase inhibitor, in adult patients with atopic dermatitis. 61
31820485 2020
47
Acute Radiation Therapy-related Dermatitis. 61
32155122 2020
48
Dermoscopy of idiopathic atrophoderma of Pasini and Pierini. 61
31424083 2020
49
A case of linear atrophoderma of Moulin. 61
31899064 2020
50
Glucocorticoid-Induced Skin Atrophy: The Old and the New. 61
33408495 2020
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Variations for Skin Atrophy

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Expression for Skin Atrophy

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Search GEO for disease gene expression data for Skin Atrophy.
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Pathways for Skin Atrophy

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Pathways related to Skin Atrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
DNA Damage 4
12.03 WRN RECQL4 LMNA DDIT4
2
Adhesion 4
11.59 GJA1 FERMT1 CD44
3
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.31 HBEGF GJA1 CD44
4
Parathyroid hormone synthesis, secretion and action 36
10.95 TRPV5 KL HBEGF FGF23
5
Cell adhesion_ECM remodeling 23
10.92 MMP1 HBEGF CD44
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GO Terms for Skin Atrophy

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Biological processes related to Skin Atrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.65 ZMPSTE24 LMNA GJA1 FGF23 ERCC6
2 DNA duplex unwinding GO:0032508 9.5 WRN RECQL4 ERCC6
3 nuclear envelope organization GO:0006998 9.43 ZMPSTE24 LMNA
4 hyaluronan catabolic process GO:0030214 9.4 HYAL3 CD44
5 DNA unwinding involved in DNA replication GO:0006268 9.37 WRN RECQL4
6 cellular response to parathyroid hormone stimulus GO:0071374 9.16 GJA1 FGF23
7 telomeric D-loop disassembly GO:0061820 8.96 WRN RECQL4
8 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 8.62 KL FGF23

Molecular functions related to Skin Atrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA helicase activity GO:0003678 9.43 WRN RECQL4 ERCC6
2 structural constituent of epidermis GO:0030280 9.37 LORICRIN FLG
3 3'-5' DNA helicase activity GO:0043138 9.32 WRN RECQL4
4 bubble DNA binding GO:0000405 9.16 WRN RECQL4
5 four-way junction helicase activity GO:0009378 8.96 WRN RECQL4
6 telomeric D-loop binding GO:0061821 8.62 WRN RECQL4
Sources

Sources for Skin Atrophy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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