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MCID: SKN013
MIFTS: 43

Skin Benign Neoplasm

Categories: Cancer diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Skin Benign Neoplasm

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MalaCards integrated aliases for Skin Benign Neoplasm:

Name: Skin Benign Neoplasm 12 15
Skin Neoplasms 44 73
Neoplasm of Skin by Site 12
Benign Neoplasm of Skin 73
Tumor of the Skin 12
Skin Tumor 55

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3165
MeSH 44 D012878
NCIt 50 C3372
SNOMED-CT 68 126488004 363230005
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Summaries for Skin Benign Neoplasm

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MalaCards based summary : Skin Benign Neoplasm, also known as skin neoplasms, is related to mixed cell type cancer and malignant granular cell skin tumor, and has symptoms including exanthema and pruritus. An important gene associated with Skin Benign Neoplasm is KRT14 (Keratin 14), and among its related pathways/superpathways are Circadian entrainment and TCR Signaling (Qiagen). The drugs Diclofenac and Ornithine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

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Related Diseases for Skin Benign Neoplasm

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Diseases in the Skin Benign Neoplasm family:

Skin Carcinoma in Situ

Diseases related to Skin Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 mixed cell type cancer 29.8 ENO2 HRAS KRT5
2 malignant granular cell skin tumor 11.8
3 eccrine sweat gland neoplasm 11.0
4 epidermolysis bullosa simplex, autosomal recessive 1 10.9 KRT14 KRT5
5 benign breast adenomyoepithelioma 10.9 KRT14 KRT5
6 epidermolysis bullosa simplex, localized 10.9 KRT14 KRT5
7 lichen planopilaris 10.9 KRT14 KRT5
8 large cell acanthoma 10.8 KRT14 KRT5
9 apocrine sweat gland neoplasm 10.8 KRT14 KRT5
10 ichthyosis hystrix, curth-macklin type 10.8 KRT1 KRT5
11 skin glomus tumor 10.8
12 epidermolysis bullosa simplex, generalized 10.8 KRT14 KRT5
13 lower lip cancer 10.8 MLH1 MSH2
14 basal cell carcinoma, infundibulocystic 10.8 KRT14 KRT20
15 attenuated familial adenomatous polyposis 10.8 MSH2 MSH6
16 epidermolysis bullosa simplex with mottled pigmentation 10.8 KRT14 KRT5
17 anal fistula 10.8 MLH1 MSH2
18 sensory organ benign neoplasm 10.7 ENO2 KRT5
19 gastric leiomyoma 10.7 MLH1 MSH6
20 middle ear adenoma 10.7 ENO2 KRT5
21 breast squamous cell carcinoma 10.6 KRT14 KRT5
22 striate palmoplantar keratoderma 10.6 KRT1 KRT14
23 neurofibromatosis, type i 10.6
24 malignant syringoma 10.6
25 mature teratoma of the ovary 10.6 ENO2 KRT20
26 cutaneous ganglioneuroma 10.6 ENO2 KRT20
27 jejunal adenocarcinoma 10.6 KRT20 MSH6
28 appendix carcinoid tumor 10.6 MLH1 MSH2 MSH6
29 adenosquamous colon carcinoma 10.6 MLH1 MSH2 MSH6
30 sweat gland cancer 10.6 KRT14 KRT20 KRT5
31 small cell carcinoma of the bladder 10.6 ENO2 KRT20
32 sebaceous adenoma 10.6 MLH1 MSH2 MSH6
33 frontal sinus inverted papilloma 10.6 KRT13 KRT5
34 frontal sinus cancer 10.6 KRT13 KRT5
35 odontoma 10.6 KRT14 KRT5
36 lynch syndrome i 10.6 MLH1 MSH2 MSH6
37 ichthyosis bullosa of siemens 10.6 KRT1 KRT14 KRT5
38 muir-torre syndrome 10.6 MLH1 MSH2 MSH6
39 goblet cell carcinoid 10.6 ENO2 KRT20
40 epidermolysis bullosa simplex 10.6 KRT1 KRT14 KRT5
41 mismatch repair cancer syndrome 10.6 MLH1 MSH2 MSH6
42 familial adenomatous polyposis 10.5 MLH1 MSH2 MSH6
43 breast adenomyoepithelioma 10.5 ENO2 KRT14 KRT5
44 breast myoepithelial neoplasm 10.5 ENO2 KRT14 KRT5
45 cervical clear cell adenocarcinoma 10.5 ENO2 KRT14 KRT5
46 autosomal dominant disease 10.5 MLH1 MSH2 MSH6
47 malignant ectomesenchymoma 10.5 ENO2 HRAS
48 rete testis adenocarcinoma 10.4 ENO2 KRT20
49 gastric squamous cell carcinoma 10.4 ENO2 KRT5
50 lymphoepithelioma-like carcinoma 10.4 ENO2 KRT20 KRT5

Graphical network of the top 20 diseases related to Skin Benign Neoplasm:



Diseases related to Skin Benign Neoplasm
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Symptoms & Phenotypes for Skin Benign Neoplasm

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UMLS symptoms related to Skin Benign Neoplasm:


exanthema, pruritus

GenomeRNAi Phenotypes related to Skin Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 MLH1 MSH2 MSH6 XPA XPC

MGI Mouse Phenotypes related to Skin Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 SLC2A1 KRT14 COL1A1 ENO2 MLH1 FLCN
2 growth/size/body region MP:0005378 10.06 KRT14 COL1A1 KRT5 ENO2 FLCN HRAS
3 homeostasis/metabolism MP:0005376 10 KRT14 COL1A1 MLH1 FLCN MSH2 HRAS
4 craniofacial MP:0005382 9.85 KRT14 COL1A1 KRT5 ENO2 HRAS XPA
5 integument MP:0010771 9.85 KRT14 COL1A1 KRT5 MLH1 MSH2 HRAS
6 mortality/aging MP:0010768 9.77 SLC2A1 KRT14 COL1A1 KRT5 MLH1 FLCN
7 neoplasm MP:0002006 9.28 COL1A1 MLH1 FLCN MSH2 HRAS MSH6
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Drugs & Therapeutics for Skin Benign Neoplasm

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Drugs for Skin Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 2 15307-86-5 3033
2
Ornithine Approved, Nutraceutical Phase 2 70-26-8, 3184-13-2 6262
3 Analgesics Phase 2
4 Analgesics, Non-Narcotic Phase 2
5 Anti-Infective Agents Phase 2
6 Anti-Inflammatory Agents Phase 2
7 Anti-Inflammatory Agents, Non-Steroidal Phase 2
8 Antiparasitic Agents Phase 2
9 Antiprotozoal Agents Phase 2
10 Antirheumatic Agents Phase 2
11 Cyclooxygenase Inhibitors Phase 2
12 Peripheral Nervous System Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Eflornithine and/or Diclofenac in Treating Patients With Sun-Damaged Skin Completed NCT00601640 Phase 2 Diclofenac Na gel;Eflornithine HCL ointment
2 Clinicopathological and Molecular Correlation of Acrochordon in Relation to Human Papillomavirus Infection Unknown status NCT00520078
3 The Impact of Total Body Skin Examination on Skin Cancer Detection Completed NCT00765193 Not Applicable
4 Optical Tomographic Scanner for Skin Lesions Recruiting NCT02891291
5 Analysis of Plasma for Diagnosis and Follow-up of Neurofibromatosis Type 1 Enrolling by invitation NCT02680431

Search NIH Clinical Center for Skin Benign Neoplasm

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: skin neoplasms

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Genetic Tests for Skin Benign Neoplasm

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Anatomical Context for Skin Benign Neoplasm

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MalaCards organs/tissues related to Skin Benign Neoplasm:

41
Skin
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Publications for Skin Benign Neoplasm

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Articles related to Skin Benign Neoplasm:

(show all 11)
# Title Authors Year
1
The impact of molecular morphology techniques on the expert diagnosis in melanocytic skin neoplasms. ( 23775023 )
2013
2
Atypical fibroxanthoma: an unusual skin neoplasm in xeroderma pigmentosum. ( 23112360 )
2012
3
Detection of Merkel cell polyomavirus in epidermodysplasia-verruciformis-associated skin neoplasms. ( 21099200 )
2011
4
Symplastic glomus tumor - a rare but distinct benign histological variant with analogy to other 'ancient' benign skin neoplasms. ( 19602065 )
2009
5
Telomerase expression in benign and malignant skin neoplasms: comparison of three major subunits. ( 12440093 )
2002
6
p53 immunoreactivity in cutaneous PUVA tumors is similar to that in other non-melanoma skin neoplasms. ( 8300928 )
1993
7
Distribution of complement regulators (CD46, CD55 and CD59) in skin appendages, and in benign and malignant skin neoplasms. ( 1379063 )
1992
8
Differentiating seborrheic keratosis from skin neoplasm. ( 4007500 )
1985
9
Trends in mortality rate from malignant skin melanoma and other malignant skin neoplasms in Czechoslovakia during the period 1921--1970. ( 1004663 )
1976
10
[Epithelial tumor-like changes, precancerous conditions and skin neoplasms (standardization study)]. ( 1009615 )
1976
11
Trends in morbidity on the basis of newly-reported cases of malignant skin melanoma (172 ICD) and other skin neoplasms (173 ICD) in Czechoslovakia during the period 1961--1972. ( 1004662 )
1976
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Variations for Skin Benign Neoplasm

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Expression for Skin Benign Neoplasm

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Search GEO for disease gene expression data for Skin Benign Neoplasm.
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Pathways for Skin Benign Neoplasm

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Pathways related to Skin Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Circadian entrainment 37
Show member pathways
 12.72 COL1A1 HRAS KRT13 KRT14 KRT20
2
TCR Signaling (Qiagen) 64
Show member pathways
 12.61 HRAS MLH1 MSH2 MSH6 XPC
3
Pathways in cancer 37
12.49 HRAS MLH1 MSH2 MSH6 SLC2A1
4
DNA Damage 4
12.19 MLH1 MSH2 MSH6 XPA XPC
5
Keratinization 66
Show member pathways
 12.11 KRT1 KRT13 KRT14 KRT20 KRT5
6
Integrated Breast Cancer Pathway 1
11.84 MSH2 MSH6 ODC1
7
Mismatch repair 37 66 1
Show member pathways
 11.57 MLH1 MSH2 MSH6
8
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 11.49 KRT1 KRT13 KRT14 KRT5
9
Platinum drug resistance 37
11.12 MLH1 MSH2 MSH6 XPA
10
Platinum Pathway, Pharmacokinetics/Pharmacodynamics 61
10.39 MLH1 MSH2 MSH6 XPA
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GO Terms for Skin Benign Neoplasm

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Cellular components related to Skin Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.46 KRT1 KRT13 KRT14 KRT5
2 MutSalpha complex GO:0032301 9.26 MSH2 MSH6
3 mismatch repair complex GO:0032300 9.13 MLH1 MSH2 MSH6
4 intermediate filament GO:0005882 9.02 KRT1 KRT13 KRT14 KRT20 KRT5
5 cytosol GO:0005829 10.06 ENO2 FLCN HRAS KRT1 KRT13 KRT14

Biological processes related to Skin Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.95 MLH1 MSH2 MSH6 XPA XPC
2 DNA repair GO:0006281 9.85 MLH1 MSH2 MSH6 XPA XPC
3 keratinization GO:0031424 9.77 KRT1 KRT13 KRT14 KRT20 KRT5
4 nucleotide-excision repair, DNA damage recognition GO:0000715 9.62 XPA XPC
5 nucleotide-excision repair, DNA duplex unwinding GO:0000717 9.61 XPA XPC
6 intra-S DNA damage checkpoint GO:0031573 9.61 MSH2 XPC
7 determination of adult lifespan GO:0008340 9.6 MSH2 MSH6
8 hemidesmosome assembly GO:0031581 9.59 KRT14 KRT5
9 UV-damage excision repair GO:0070914 9.58 XPA XPC
10 response to auditory stimulus GO:0010996 9.58 XPA XPC
11 somatic hypermutation of immunoglobulin genes GO:0016446 9.58 MLH1 MSH2 MSH6
12 response to UV-B GO:0010224 9.57 MSH2 XPC
13 positive regulation of isotype switching to IgG isotypes GO:0048304 9.56 MLH1 MSH2
14 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.56 MLH1 MSH2 MSH6 XPA
15 cornification GO:0070268 9.55 KRT1 KRT13 KRT14 KRT20 KRT5
16 positive regulation of helicase activity GO:0051096 9.54 MSH2 MSH6
17 negative regulation of DNA recombination GO:0045910 9.52 MSH2 MSH6
18 maintenance of DNA repeat elements GO:0043570 9.51 MSH2 MSH6
19 isotype switching GO:0045190 9.5 MLH1 MSH2 MSH6
20 positive regulation of isotype switching to IgA isotypes GO:0048298 9.49 MLH1 MSH2
21 meiotic mismatch repair GO:0000710 9.48 MSH2 MSH6
22 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.43 MLH1 MSH2
23 mismatch repair GO:0006298 9.26 MLH1 MSH2 MSH6 XPC
24 somatic recombination of immunoglobulin gene segments GO:0016447 8.8 MLH1 MSH2 MSH6

Molecular functions related to Skin Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.69 KRT14 KRT20 KRT5
2 single-stranded DNA binding GO:0003697 9.67 MLH1 MSH2 XPC
3 four-way junction DNA binding GO:0000400 9.52 MSH2 MSH6
4 oxidized purine DNA binding GO:0032357 9.48 MSH2 MSH6
5 MutLalpha complex binding GO:0032405 9.46 MSH2 MSH6
6 damaged DNA binding GO:0003684 9.46 MSH2 MSH6 XPA XPC
7 heteroduplex DNA loop binding GO:0000404 9.43 MSH2 XPC
8 single guanine insertion binding GO:0032142 9.4 MSH2 MSH6
9 single base insertion or deletion binding GO:0032138 9.37 MSH2 MSH6
10 single thymine insertion binding GO:0032143 9.32 MSH2 MSH6
11 mismatched DNA binding GO:0030983 9.13 MLH1 MSH2 MSH6
12 guanine/thymine mispair binding GO:0032137 8.8 MLH1 MSH2 MSH6
13 protein binding GO:0005515 10.16 COL1A1 ENO2 FLCN HRAS KRT1 KRT13
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Sources for Skin Benign Neoplasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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