MCID: SKN013
MIFTS: 51

Skin Benign Neoplasm

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Skin Benign Neoplasm

MalaCards integrated aliases for Skin Benign Neoplasm:

Name: Skin Benign Neoplasm 12 15
Skin Neoplasms 44 73
Neoplasm of Skin by Site 12
Benign Neoplasm of Skin 73
Tumor of the Skin 12
Skin Tumor 55

Classifications:



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Disease Ontology 12 DOID:3165
MeSH 44 D012878
NCIt 50 C3372

Summaries for Skin Benign Neoplasm

MalaCards based summary : Skin Benign Neoplasm, also known as skin neoplasms, is related to muir-torre syndrome and melanocytic nevus syndrome, congenital, and has symptoms including pruritus and exanthema. An important gene associated with Skin Benign Neoplasm is KRT14 (Keratin 14), and among its related pathways/superpathways are Circadian entrainment and TCR Signaling (Qiagen). The drugs Diclofenac and Ornithine have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and kidney, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Related Diseases for Skin Benign Neoplasm

Diseases in the Skin Benign Neoplasm family:

Skin Carcinoma in Situ

Diseases related to Skin Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 muir-torre syndrome 31.9 MLH1 MSH2 MSH6
2 melanocytic nevus syndrome, congenital 31.6 HRAS MLH1 MSH2
3 lynch syndrome i 31.4 MLH1 MSH2 MSH6
4 lymphoepithelioma-like carcinoma 29.7 ENO2 KRT20 KRT5
5 basal cell carcinoma 29.3 CD34 KRT14 KRT20 KRT5 XPA
6 papilloma 29.0 KRT1 KRT13 KRT14 KRT20 KRT5 ODC1
7 malignant granular cell skin tumor 12.0
8 eccrine sweat gland neoplasm 11.1
9 skin glomus tumor 11.0
10 cylindromatosis, familial 10.9
11 multiple self-healing squamous epithelioma 10.9
12 birt-hogg-dube syndrome 10.9
13 uv-sensitive syndrome 1 10.9
14 trichoepithelioma, multiple familial, 1 10.9
15 brooke-spiegler syndrome 10.9
16 uv-sensitive syndrome 2 10.9
17 uv-sensitive syndrome 3 10.9
18 basal cell carcinoma 7 10.8
19 acanthoma 10.8
20 neurofibromatosis, type i 10.8
21 malignant syringoma 10.8
22 neurofibromatosis, type iv, of riccardi 10.7
23 keratosis, seborrheic 10.7
24 schopf-schulz-passarge syndrome 10.7
25 epidermodysplasia verruciformis 10.7
26 eccrine porocarcinoma 10.7
27 skin melanoma 10.5
28 pilomatrixoma 10.4
29 benign breast adenomyoepithelioma 10.3 KRT14 KRT5
30 lichen planopilaris 10.3 KRT14 KRT5
31 epidermolysis bullosa simplex, autosomal recessive 1 10.3 KRT14 KRT5
32 basal cell carcinoma, infundibulocystic 10.3 KRT14 KRT20
33 large cell acanthoma 10.3 KRT14 KRT5
34 colorectal cancer, hereditary nonpolyposis, type 7 10.3 MLH1 MSH2
35 ichthyosis hystrix, curth-macklin type 10.3 KRT1 KRT5
36 colorectal cancer 5 10.3 MLH1 MSH6
37 lower lip cancer 10.3 MLH1 MSH2
38 attenuated familial adenomatous polyposis 10.3 MSH2 MSH6
39 apocrine sweat gland neoplasm 10.3 KRT14 KRT5
40 epidermolysis bullosa simplex, localized 10.3 KRT14 KRT5
41 epidermolysis bullosa simplex, generalized 10.3 KRT14 KRT5
42 anal fistula 10.3 MLH1 MSH2
43 breast squamous cell carcinoma 10.2 KRT14 KRT5
44 epidermolysis bullosa simplex with mottled pigmentation 10.2 KRT14 KRT5
45 jejunal adenocarcinoma 10.2 KRT20 MSH6
46 papillary transitional carcinoma 10.2 ENO2 KRT20
47 sensory organ benign neoplasm 10.2 ENO2 KRT5
48 middle ear adenoma 10.2 ENO2 KRT5
49 cutaneous ganglioneuroma 10.2 ENO2 KRT20
50 gastric leiomyoma 10.2 MLH1 MSH6

Graphical network of the top 20 diseases related to Skin Benign Neoplasm:



Diseases related to Skin Benign Neoplasm

Symptoms & Phenotypes for Skin Benign Neoplasm

UMLS symptoms related to Skin Benign Neoplasm:


pruritus, exanthema

GenomeRNAi Phenotypes related to Skin Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 MLH1 MSH2 MSH6 XPA XPC

MGI Mouse Phenotypes related to Skin Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.17 CD34 COL1A1 ENO2 FLCN KRT14 MLH1
2 growth/size/body region MP:0005378 10.07 COL1A1 ENO2 FLCN HRAS KRT1 KRT14
3 homeostasis/metabolism MP:0005376 10 CD34 COL1A1 FLCN HRAS KRT1 KRT14
4 hematopoietic system MP:0005397 9.97 CD34 COL1A1 FLCN KRT1 KRT14 MLH1
5 integument MP:0010771 9.9 CD34 COL1A1 HRAS KRT1 KRT14 KRT5
6 craniofacial MP:0005382 9.88 COL1A1 ENO2 HRAS KRT14 KRT5 XPA
7 mortality/aging MP:0010768 9.73 COL1A1 FLCN HRAS KRT1 KRT14 KRT5
8 neoplasm MP:0002006 9.32 CD34 COL1A1 FLCN HRAS KRT14 MLH1

Drugs & Therapeutics for Skin Benign Neoplasm

Drugs for Skin Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 2 15307-86-5 3033
2
Ornithine Approved, Nutraceutical Phase 2 3184-13-2, 70-26-8 6262
3 Antiparasitic Agents Phase 2
4 Antirheumatic Agents Phase 2
5 Analgesics, Non-Narcotic Phase 2
6 Analgesics Phase 2
7 Anti-Inflammatory Agents, Non-Steroidal Phase 2
8 Peripheral Nervous System Agents Phase 2
9 Antiprotozoal Agents Phase 2
10 Anti-Infective Agents Phase 2
11 Cyclooxygenase Inhibitors Phase 2
12 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Eflornithine and/or Diclofenac in Treating Patients With Sun-Damaged Skin Completed NCT00601640 Phase 2 Diclofenac Na gel;Eflornithine HCL ointment
2 Clinicopathological and Molecular Correlation of Acrochordon in Relation to Human Papillomavirus Infection Unknown status NCT00520078
3 The Impact of Total Body Skin Examination on Skin Cancer Detection Completed NCT00765193 Not Applicable
4 Optical Tomographic Scanner for Skin Lesions Recruiting NCT02891291
5 Analysis of Plasma for Diagnosis and Follow-up of Neurofibromatosis Type 1 Enrolling by invitation NCT02680431

Search NIH Clinical Center for Skin Benign Neoplasm

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: skin neoplasms

Genetic Tests for Skin Benign Neoplasm

Anatomical Context for Skin Benign Neoplasm

MalaCards organs/tissues related to Skin Benign Neoplasm:

41
Skin, Lymph Node, Kidney, Liver, Colon, Thyroid, T Cells

Publications for Skin Benign Neoplasm

Articles related to Skin Benign Neoplasm:

(show top 50) (show all 100)
# Title Authors Year
1
Recent use of medical infrared thermography in skin neoplasms. ( 29575378 )
2018
2
Store-and-forward teledermatology for the most common skin neoplasms in Ukraine. ( 29945264 )
2018
3
Risk of malignant skin neoplasms in a cohort of workers occupationally exposed to ionizing radiation at low dose rates. ( 30289933 )
2018
4
Risk factors for development of new skin neoplasms in patients with past history of skin cancer: A survival analysis. ( 30356134 )
2018
5
Identification of Felis catus papillomavirus 3 in skin neoplasms from four cats. ( 29284382 )
2018
6
Pigmentation phenotype, photosensitivity and skin neoplasms in patients with myotonic dystrophy. ( 28317292 )
2017
7
Cytology of Skin Neoplasms. ( 27531041 )
2017
8
Pigmented globules in dermoscopy as a clue for lentigomaligna mimicking non-melanocytic skin neoplasms: a lesson from reflectance confocal microscopy. ( 25690720 )
2016
9
Associations of Selected Cytokines Levels in Organ Transplant Recipients Without and With Malignant Skin Neoplasms. ( 27496466 )
2016
10
Dysplastic nevi, cutaneous melanoma, and other skin neoplasms in patients with myotonic dystrophy type 1: a cross-sectional study. ( 25440959 )
2015
11
Risk of radiation-induced skin neoplasms after radiotherapy for cutaneous malignant tumors: a study on 5875 patients. ( 24990279 )
2015
12
Reliability of store and forward teledermatology for skin neoplasms. ( 25599624 )
2015
13
Multiple skin neoplasms in subjects under 40 years of age in Goiania, Brazil. ( 26465667 )
2015
14
Expression of cancer-related carbonic anhydrases IX and XII in normal skin and skin neoplasms. ( 24698175 )
2014
15
Molecular pathology of skin neoplasms of the head and neck. ( 24878016 )
2014
16
Contribution of dynamic sentinel lymphoscintigraphy images to the diagnosis of patients with malignant skin neoplasms in the upper and lower extremities. ( 25392795 )
2014
17
The impact of molecular morphology techniques on the expert diagnosis in melanocytic skin neoplasms. ( 23775023 )
2013
18
Cancer-associated genodermatoses: skin neoplasms as clues to hereditary tumor syndromes. ( 22823951 )
2013
19
Benign skin neoplasms. ( 23369586 )
2013
20
Bibliography. Melanoma and other skin neoplasms. Current world literature. ( 23509846 )
2013
21
Endoscopic groin lymph node dissection as a preferable technique for malignant skin neoplasms. ( 23627646 )
2013
22
Rosettes: optical effects and not dermoscopic patterns related to skin neoplasms. ( 23841852 )
2013
23
Communicating the location of potential skin neoplasms for excision between the referring and the operating doctor--an audit of skin lesion referrals in Whanganui, New Zealand. ( 24150263 )
2013
24
Role of imprint/exfoliative cytology in ulcerated skin neoplasms. ( 24426765 )
2013
25
Detection of Merkel cell polyomavirus in epidermodysplasia-verruciformis-associated skin neoplasms. ( 21099200 )
2011
26
Face skin neoplasms--reasons for delayed treatment. ( 22166663 )
2011
27
Immunohistochemical Reactivity of the 14F7 Monoclonal Antibody Raised against N-Glycolyl GM3 Ganglioside in Some Benign and Malignant Skin Neoplasms. ( 22363862 )
2011
28
Interobserver accuracy of store and forward teledermatology for skin neoplasms. ( 20159321 )
2010
29
Accuracy of teledermatology/teledermoscopy and clinic-based dermatology for specific categories of skin neoplasms. ( 20633809 )
2010
30
Lymphoscintigraphy for sentinel lymph node mapping in Japanese patients with malignant skin neoplasms of the lower extremities: comparison with previously investigated Japanese lymphatic anatomy. ( 20809139 )
2010
31
Symplastic glomus tumor - a rare but distinct benign histological variant with analogy to other 'ancient' benign skin neoplasms. ( 19602065 )
2009
32
The influence of clinical information in the histopathologic diagnosis of melanocytic skin neoplasms. ( 19404399 )
2009
33
Malignant skin neoplasms. ( 19932329 )
2009
34
Bibliography. Current world literature. Melanoma and other skin neoplasms. ( 18309543 )
2008
35
Current world literature. Melanoma and other skin neoplasms. ( 17333568 )
2007
36
The expression pattern of prostaglandin E synthase and EP receptor isoforms in normal mouse skin and preinvasive skin neoplasms. ( 17437488 )
2007
37
Bibliography. Current world literature. Melanoma and other skin neoplasms. ( 15877317 )
2005
38
A pilot study of a combined dermoscopic-pathological approach to the telediagnosis of melanocytic skin neoplasms. ( 15006214 )
2004
39
Bibliography. Current world literature. Melanoma and other skin neoplasms. ( 15083802 )
2004
40
Comparison of skin biopsy triage decisions in 49 patients with pigmented lesions and skin neoplasms: store-and-forward teledermatology vs face-to-face dermatology. ( 15148095 )
2004
41
The spectrum of mesenchymal skin neoplasms reflected by the new WHO classification. ( 15347899 )
2004
42
Telomerase expression in benign and malignant skin neoplasms: comparison of three major subunits. ( 12440093 )
2002
43
Bibliography. Current world literature. Melanoma and other skin neoplasms. ( 11936076 )
2002
44
Bibliography. Current world literature. Melanoma and other skin neoplasms. ( 11293396 )
2001
45
Bibliography. Current world literature. Melanoma and other skin neoplasms. ( 10750734 )
2000
46
Bibliography. Current world literature. Melanoma and other skin neoplasms. ( 10188083 )
1999
47
Melanoma and other skin neoplasms. ( 9555539 )
1998
48
Melanoma and other skin neoplasms. ( 9555545 )
1998
49
CD44 and variants in melanocytic skin neoplasms. ( 9609138 )
1998
50
Expression of CCAAT/enhancer binding proteins (C/EBP) is associated with squamous differentiation in epidermis and isolated primary keratinocytes and is altered in skin neoplasms. ( 9620302 )
1998

Variations for Skin Benign Neoplasm

Expression for Skin Benign Neoplasm

Search GEO for disease gene expression data for Skin Benign Neoplasm.

Pathways for Skin Benign Neoplasm

GO Terms for Skin Benign Neoplasm

Cellular components related to Skin Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.46 KRT1 KRT13 KRT14 KRT5
2 intermediate filament GO:0005882 9.35 KRT1 KRT13 KRT14 KRT20 KRT5
3 MutSalpha complex GO:0032301 9.26 MSH2 MSH6
4 mismatch repair complex GO:0032300 8.8 MLH1 MSH2 MSH6
5 cytosol GO:0005829 10.06 ENO2 FLCN HBA1 HRAS KRT1 KRT13

Biological processes related to Skin Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.95 MLH1 MSH2 MSH6 XPA XPC
2 DNA repair GO:0006281 9.88 MLH1 MSH2 MSH6 XPA XPC
3 keratinization GO:0031424 9.72 KRT1 KRT13 KRT14 KRT20 KRT5
4 negative regulation of DNA recombination GO:0045910 9.62 MSH2 MSH6
5 determination of adult lifespan GO:0008340 9.61 MSH2 MSH6
6 intra-S DNA damage checkpoint GO:0031573 9.61 MSH2 XPC
7 hemidesmosome assembly GO:0031581 9.6 KRT14 KRT5
8 UV-damage excision repair GO:0070914 9.59 XPA XPC
9 response to UV-B GO:0010224 9.58 MSH2 XPC
10 positive regulation of isotype switching to IgG isotypes GO:0048304 9.58 MLH1 MSH2
11 somatic hypermutation of immunoglobulin genes GO:0016446 9.58 MLH1 MSH2 MSH6
12 response to auditory stimulus GO:0010996 9.57 XPA XPC
13 positive regulation of helicase activity GO:0051096 9.56 MSH2 MSH6
14 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.56 MLH1 MSH2 MSH6 XPA
15 cornification GO:0070268 9.55 KRT1 KRT13 KRT14 KRT20 KRT5
16 pyrimidine dimer repair GO:0006290 9.54 MSH2 MSH6
17 isotype switching GO:0045190 9.54 MLH1 MSH2 MSH6
18 replication fork arrest GO:0043111 9.52 MSH2 MSH6
19 maintenance of DNA repeat elements GO:0043570 9.51 MSH2 MSH6
20 positive regulation of isotype switching to IgA isotypes GO:0048298 9.49 MLH1 MSH2
21 meiotic mismatch repair GO:0000710 9.46 MSH2 MSH6
22 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.43 MLH1 MSH2
23 mismatch repair GO:0006298 9.26 MLH1 MSH2 MSH6 XPC
24 somatic recombination of immunoglobulin gene segments GO:0016447 8.8 MLH1 MSH2 MSH6

Molecular functions related to Skin Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.67 KRT14 KRT20 KRT5
2 single-stranded DNA binding GO:0003697 9.65 MLH1 MSH2 XPC
3 four-way junction DNA binding GO:0000400 9.51 MSH2 MSH6
4 MutLalpha complex binding GO:0032405 9.46 MSH2 MSH6
5 damaged DNA binding GO:0003684 9.46 MSH2 MSH6 XPA XPC
6 oxidized purine DNA binding GO:0032357 9.43 MSH2 MSH6
7 single thymine insertion binding GO:0032143 9.4 MSH2 MSH6
8 heteroduplex DNA loop binding GO:0000404 9.37 MSH2 XPC
9 single guanine insertion binding GO:0032142 9.32 MSH2 MSH6
10 mismatched DNA binding GO:0030983 9.13 MLH1 MSH2 MSH6
11 guanine/thymine mispair binding GO:0032137 8.8 MLH1 MSH2 MSH6
12 protein binding GO:0005515 10.16 COL1A1 ENO2 FLCN HBA1 HRAS KRT1

Sources for Skin Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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