MCID: SKN012
MIFTS: 24

Skin Carcinoma in Situ

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Skin Carcinoma in Situ

Summaries for Skin Carcinoma in Situ

Disease Ontology : 12 A carcinoma in situ that is characterized by the spread of cancer in skin and the lack of invasion of surrounding tissues.

MalaCards based summary : Skin Carcinoma in Situ, also known as carcinoma in situ of skin, is related to keratosis and actinic keratosis. An important gene associated with Skin Carcinoma in Situ is ZC3H12D (Zinc Finger CCCH-Type Containing 12D), and among its related pathways/superpathways are Mitochondrial Gene Expression and Apelin signaling pathway. The drugs Paclitaxel and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include skin and colon.

Related Diseases for Skin Carcinoma in Situ

Diseases in the Skin Carcinoma family:

Skin Carcinoma in Situ

Diseases related to Skin Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 keratosis 9.8
2 actinic keratosis 9.8
3 bowen's disease 9.8
4 in situ carcinoma 9.8

Symptoms & Phenotypes for Skin Carcinoma in Situ

Drugs & Therapeutics for Skin Carcinoma in Situ

Drugs for Skin Carcinoma in Situ (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
3
Gemcitabine Approved Phase 2 95058-81-4 60750
4
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
5 Albumin-Bound Paclitaxel Phase 2
6 Antimitotic Agents Phase 2
7 Cola Phase 2
8 Antimetabolites Phase 2
9 Immunosuppressive Agents Phase 2
10 Anti-Infective Agents Phase 2
11 Immunologic Factors Phase 2
12 Antiviral Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Trial of Abraxane and Capecitabine in Metastatic Colon Cancer (COL 01) Completed NCT00625573 Phase 2 Abraxane
2 Phase I/II Trial of Infusional Gemcitabine in Combination With Carboplatin in Chemonaive Non-small Cell Carcinoma Completed NCT00212043 Phase 2 carboplatin and gemcitabine
3 Effects of Arsenic on Keratinocytes in a Skin Equivalent Model Unknown status NCT00166946

Search NIH Clinical Center for Skin Carcinoma in Situ

Genetic Tests for Skin Carcinoma in Situ

Anatomical Context for Skin Carcinoma in Situ

MalaCards organs/tissues related to Skin Carcinoma in Situ:

40
Skin, Colon

Publications for Skin Carcinoma in Situ

Articles related to Skin Carcinoma in Situ:

# Title Authors PMID Year
1
Assessment of Deep Learning Using Nonimaging Information and Sequential Medical Records to Develop a Prediction Model for Nonmelanoma Skin Cancer. 61
31483437 2019
2
STAT3-dependent VEGF production from keratinocytes abrogates dendritic cell activation and migration by arsenic: a plausible regional mechanism of immunosuppression in arsenical cancers. 61
25559853 2015
3
P16(INK4A) expression in Bowen's disease and Bowenoid papulosis. 61
17100385 2006
4
Squamous carcinoma in situ of the skin containing premelanosomes, with melanocytic colonization of the tumor. 61
10333222 1999

Variations for Skin Carcinoma in Situ

Expression for Skin Carcinoma in Situ

Search GEO for disease gene expression data for Skin Carcinoma in Situ.

Pathways for Skin Carcinoma in Situ

GO Terms for Skin Carcinoma in Situ

Biological processes related to Skin Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion organization GO:0007005 8.62 TFAM NRF1

Sources for Skin Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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