MCID: SKN012
MIFTS: 40

Skin Carcinoma in Situ

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Skin Carcinoma in Situ

Summaries for Skin Carcinoma in Situ

Disease Ontology : 12 A carcinoma in situ that is characterized by the spread of cancer in skin and the lack of invasion of surrounding tissues.

MalaCards based summary : Skin Carcinoma in Situ, also known as carcinoma in situ of skin, is related to bartholin's gland benign neoplasm and lymphohistiocytoid mesothelioma. An important gene associated with Skin Carcinoma in Situ is TFAM (Transcription Factor A, Mitochondrial), and among its related pathways/superpathways are Human cytomegalovirus infection and Endometrial cancer. Affiliated tissues include skin, colon and lung, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for Skin Carcinoma in Situ

Diseases in the Skin Benign Neoplasm family:

Skin Carcinoma in Situ

Diseases related to Skin Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 bartholin's gland benign neoplasm 10.1 CD86 CDKN2A
2 lymphohistiocytoid mesothelioma 10.1 CD86 CDKN2A
3 vulval paget's disease 10.1 CD86 CDKN2A
4 bartholin's gland disease 10.1 CD86 CDKN2A
5 vulva adenocarcinoma 10.1 CD86 CDKN2A
6 bone squamous cell carcinoma 10.1 CDKN2A STAT3
7 autosomal dominant non-syndromic intellectual disability 2 10.1 HPGDS PPARG
8 gastric adenosquamous carcinoma 10.1 CDKN2A STAT3
9 autosomal dominant non-syndromic intellectual disability 3 10.1 HPGDS PPARG
10 breast papillomatosis 10.1 CCND1 CDKN2A
11 tonsil squamous cell carcinoma 10.1 CCND1 CDKN2A
12 cervix carcinoma 10.1 CDKN2A STAT3
13 endometrial squamous cell carcinoma 10.1 CCND1 CDKN2A
14 cataract 14, multiple types 10.1 CD86 HPGDS
15 ischemic fasciitis 10.1 CCND1 CDKN2A
16 verrucous carcinoma 10.1 CCND1 CDKN2A
17 pre-malignant neoplasm 10.1 CCND1 CDKN2A
18 squamous cell papilloma 10.1 CDKN2A HPGDS
19 chondromyxoid fibroma 10.1 CCND1 CDKN2A
20 laryngeal disease 10.1 CCND1 CDKN2A
21 oropharynx cancer 10.0 CCND1 CDKN2A
22 pharynx cancer 10.0 CCND1 CDKN2A
23 inverted papilloma 10.0 CCND1 CDKN2A
24 penile cancer 10.0 CCND1 CDKN2A
25 nasopharyngeal disease 10.0 CCND1 CDKN2A
26 retinal cancer 10.0 CCND1 CDKN2A
27 supratentorial cancer 10.0 CDKN2A STAT3
28 esophageal disease 10.0 CCND1 CDKN2A
29 cerebrum cancer 10.0 CDKN2A STAT3
30 cervix disease 10.0 CCND1 CDKN2A
31 bowenoid papulosis 10.0 CCND1 CDKN2A PPARG
32 respiratory system cancer 9.9 CCND1 CDKN2A STAT3
33 gastrointestinal system cancer 9.9 CCND1 CDKN2A STAT3
34 endocrine gland cancer 9.9 CCND1 CDKN2A STAT3
35 gastrointestinal system disease 9.9 CCND1 CDKN2A STAT3
36 pancreas adenocarcinoma 9.9 CCND1 CDKN2A STAT3
37 myeloma, multiple 9.9 CCND1 CDKN2A STAT3
38 squamous cell carcinoma, head and neck 9.9 CCND1 CDKN2A STAT3
39 glioma 9.9 CCND1 CDKN2A PPARG
40 nasopharyngeal carcinoma 9.8 CCND1 CDKN2A STAT3
41 ocular cancer 9.8 CCND1 CDKN2A
42 glioblastoma multiforme 9.8 CCND1 CDKN2A PPARG STAT3
43 keratosis 9.8
44 in situ carcinoma 9.8
45 actinic keratosis 9.8
46 bowen's disease 9.8
47 gastric adenocarcinoma 9.8 CCND1 CDKN2A STAT3
48 lung cancer susceptibility 3 9.7 CCND1 CDKN2A STAT3
49 large intestine cancer 9.5 CCND1 CD86 CDKN2A HPGDS PPARG STAT3

Graphical network of the top 20 diseases related to Skin Carcinoma in Situ:



Diseases related to Skin Carcinoma in Situ

Symptoms & Phenotypes for Skin Carcinoma in Situ

GenomeRNAi Phenotypes related to Skin Carcinoma in Situ according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 CCND1 HPGDS NRF1 PPARG STAT3

MGI Mouse Phenotypes related to Skin Carcinoma in Situ:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.01 CCND1 CD86 CDKN2A HPGDS NRF1 PPARG
2 behavior/neurological MP:0005386 9.98 CCND1 CD86 CDKN2A HPGDS PPARG STAT3
3 endocrine/exocrine gland MP:0005379 9.85 CCND1 CD86 CDKN2A PPARG STAT3 TFAM
4 integument MP:0010771 9.8 CCND1 CDKN2A HPGDS PPARG STAT3 TFAM
5 muscle MP:0005369 9.65 CD86 CDKN2A PPARG STAT3 TFAM
6 neoplasm MP:0002006 9.55 CCND1 CDKN2A HPGDS PPARG STAT3
7 nervous system MP:0003631 9.5 CCND1 CD86 CDKN2A HPGDS PPARG STAT3
8 vision/eye MP:0005391 9.02 CCND1 CDKN2A PPARG STAT3 TFAM

Drugs & Therapeutics for Skin Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Skin Carcinoma in Situ

Genetic Tests for Skin Carcinoma in Situ

Anatomical Context for Skin Carcinoma in Situ

MalaCards organs/tissues related to Skin Carcinoma in Situ:

41
Skin, Colon, Lung, Bone, Tonsil, Pancreas, Cervix

Publications for Skin Carcinoma in Situ

Articles related to Skin Carcinoma in Situ:

# Title Authors Year
1
The expression of placental-type glutathione S-transferase (GST-pi) in human cutaneous carcinoma in situ, that is, actinic keratosis and Bowen's disease, compared with normal human skin. ( 7586130 )
1995

Variations for Skin Carcinoma in Situ

Expression for Skin Carcinoma in Situ

Search GEO for disease gene expression data for Skin Carcinoma in Situ.

Pathways for Skin Carcinoma in Situ

GO Terms for Skin Carcinoma in Situ

Biological processes related to Skin Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.63 CCND1 PPARG STAT3
2 cytokine-mediated signaling pathway GO:0019221 9.61 CCND1 CD86 STAT3
3 T cell costimulation GO:0031295 9.48 CCL21 CD86
4 response to organic cyclic compound GO:0014070 9.43 CCND1 PPARG STAT3
5 animal organ regeneration GO:0031100 9.4 CCND1 PPARG
6 intracellular receptor signaling pathway GO:0030522 9.37 PPARG STAT3
7 cell maturation GO:0048469 9.32 CCL21 PPARG
8 response to leptin GO:0044321 9.16 CCND1 STAT3
9 response to organic substance GO:0010033 9.13 CCND1 PPARG STAT3
10 positive regulation of transcription, DNA-templated GO:0045893 9.02 CD86 CDKN2A PPARG STAT3 TFAM

Molecular functions related to Skin Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 CCL21 CCND1 CD86 CDKN2A HPGDS NRF1
2 nuclear receptor activity GO:0004879 9.16 PPARG STAT3
3 RNA polymerase II repressing transcription factor binding GO:0001103 8.96 PPARG STAT3
4 transcription factor binding GO:0008134 8.92 CCND1 CDKN2A PPARG STAT3

Sources for Skin Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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