MCID: SKN012
MIFTS: 33

Skin Carcinoma in Situ

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Skin Carcinoma in Situ

Summaries for Skin Carcinoma in Situ

Disease Ontology : 12 A carcinoma in situ that is characterized by the spread of cancer in skin and the lack of invasion of surrounding tissues.

MalaCards based summary : Skin Carcinoma in Situ, also known as carcinoma in situ of skin, is related to lymphohistiocytoid mesothelioma and vulval paget's disease. An important gene associated with Skin Carcinoma in Situ is TFAM (Transcription Factor A, Mitochondrial), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include skin, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for Skin Carcinoma in Situ

Diseases in the Skin Benign Neoplasm family:

Skin Carcinoma in Situ

Diseases related to Skin Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 lymphohistiocytoid mesothelioma 10.4 CD86 CDKN2A
2 vulval paget's disease 10.4 CD86 CDKN2A
3 bartholin's gland benign neoplasm 10.4 CD86 CDKN2A
4 vulva adenocarcinoma 10.4 CD86 CDKN2A
5 bone squamous cell carcinoma 10.4 CDKN2A STAT3
6 gastric adenosquamous carcinoma 10.4 CDKN2A STAT3
7 cervix carcinoma 10.3 CDKN2A STAT3
8 breast papillomatosis 10.3 CCND1 CDKN2A
9 endometrial squamous cell carcinoma 10.2 CCND1 CDKN2A
10 cataract 14, multiple types 10.2 CD86 HPGDS
11 ischemic fasciitis 10.2 CCND1 CDKN2A
12 oral leukoplakia 10.2 CCND1 CDKN2A
13 squamous cell papilloma 10.2 CDKN2A HPGDS
14 pre-malignant neoplasm 10.1 CCND1 CDKN2A
15 chondromyxoid fibroma 10.1 CCND1 CDKN2A
16 gastrointestinal system benign neoplasm 10.1 CCND1 CDKN2A
17 penile cancer 10.1 CCND1 CDKN2A
18 retinal cancer 10.0 CCND1 CDKN2A
19 pharynx cancer 10.0 CCND1 CDKN2A
20 sensory system cancer 10.0 CCND1 CDKN2A
21 salivary gland cancer 9.9 PPARG STAT3
22 respiratory system cancer 9.8 CCND1 CDKN2A STAT3
23 gastrointestinal system cancer 9.8 CCND1 CDKN2A STAT3
24 pancreas adenocarcinoma 9.8 CCND1 CDKN2A STAT3
25 bowenoid papulosis 9.8 CCND1 CDKN2A PPARG
26 myeloma, multiple 9.7 CCND1 CDKN2A STAT3
27 squamous cell carcinoma, head and neck 9.7 CCND1 CDKN2A STAT3
28 lung cancer susceptibility 3 9.7 CCND1 CDKN2A STAT3
29 keratosis 9.7
30 actinic keratosis 9.7
31 bowen's disease 9.7
32 cholangiocarcinoma 9.5 CCND1 CDKN2A STAT3
33 glioma 9.4 CCND1 CDKN2A PPARG
34 ocular cancer 9.4 CCND1 CDKN2A
35 nasopharyngeal carcinoma 9.4 CCND1 CDKN2A STAT3
36 cervical cancer 9.3 CCND1 CDKN2A STAT3
37 glioblastoma multiforme 9.3 CCND1 CDKN2A PPARG STAT3

Graphical network of the top 20 diseases related to Skin Carcinoma in Situ:



Diseases related to Skin Carcinoma in Situ

Symptoms & Phenotypes for Skin Carcinoma in Situ

GenomeRNAi Phenotypes related to Skin Carcinoma in Situ according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 CCND1 HPGDS NRF1 PPARG STAT3

MGI Mouse Phenotypes related to Skin Carcinoma in Situ:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.01 HPGDS NRF1 PPARG CCND1 STAT3 CD86
2 behavior/neurological MP:0005386 9.98 HPGDS PPARG CCND1 CD86 STAT3 CDKN2A
3 endocrine/exocrine gland MP:0005379 9.85 CDKN2A TFAM PPARG CCND1 CD86 STAT3
4 integument MP:0010771 9.8 HPGDS PPARG CCND1 STAT3 CDKN2A TFAM
5 muscle MP:0005369 9.65 CDKN2A TFAM PPARG CD86 STAT3
6 neoplasm MP:0002006 9.55 HPGDS PPARG CCND1 STAT3 CDKN2A
7 nervous system MP:0003631 9.5 CDKN2A TFAM HPGDS PPARG CCND1 CD86
8 vision/eye MP:0005391 9.02 CDKN2A TFAM PPARG CCND1 STAT3

Drugs & Therapeutics for Skin Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Skin Carcinoma in Situ

Genetic Tests for Skin Carcinoma in Situ

Anatomical Context for Skin Carcinoma in Situ

MalaCards organs/tissues related to Skin Carcinoma in Situ:

41
Skin

Publications for Skin Carcinoma in Situ

Articles related to Skin Carcinoma in Situ:

# Title Authors Year
1
The expression of placental-type glutathione S-transferase (GST-pi) in human cutaneous carcinoma in situ, that is, actinic keratosis and Bowen's disease, compared with normal human skin. ( 7586130 )
1995

Variations for Skin Carcinoma in Situ

Expression for Skin Carcinoma in Situ

Search GEO for disease gene expression data for Skin Carcinoma in Situ.

Pathways for Skin Carcinoma in Situ

GO Terms for Skin Carcinoma in Situ

Biological processes related to Skin Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.91 CCND1 CDKN2A NRF1 PPARG STAT3 TFAM
2 transcription, DNA-templated GO:0006351 9.85 CCND1 CDKN2A NRF1 PPARG STAT3 TFAM
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.72 CDKN2A NRF1 PPARG STAT3 TFAM
4 cytokine-mediated signaling pathway GO:0019221 9.69 CCND1 CD86 STAT3
5 response to drug GO:0042493 9.67 CCND1 PPARG STAT3
6 animal organ regeneration GO:0031100 9.48 CCND1 PPARG
7 intracellular receptor signaling pathway GO:0030522 9.46 PPARG STAT3
8 response to organic cyclic compound GO:0014070 9.43 CCND1 PPARG STAT3
9 cell maturation GO:0048469 9.4 CCL21 PPARG
10 response to leptin GO:0044321 9.16 CCND1 STAT3
11 response to organic substance GO:0010033 9.13 CCND1 PPARG STAT3
12 positive regulation of transcription, DNA-templated GO:0045893 9.02 CD86 CDKN2A PPARG STAT3 TFAM

Molecular functions related to Skin Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.43 NRF1 STAT3 TFAM
2 nuclear receptor activity GO:0004879 9.16 PPARG STAT3
3 core promoter sequence-specific DNA binding GO:0001046 8.96 NRF1 PPARG
4 transcription factor binding GO:0008134 8.92 CCND1 CDKN2A PPARG STAT3

Sources for Skin Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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