Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: SKN016
MIFTS: 67

Skin Disease

Categories: Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Skin Disease

About this section

MalaCards integrated aliases for Skin Disease:

Name: Skin Disease 38 12 15
Abnormality of the Skin 29 6
Skin Diseases, Genetic 44 73
Skin Diseases 55 44
Skin and Subcutaneous Tissue Disease 12
Dermatologic Disorders 73
Genodermatosis 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Skin Disease

About this section
Disease Ontology : 12 An integumentary system disease that is located in skin.

MalaCards based summary : Skin Disease, also known as abnormality of the skin, is related to bullous skin disease and vesiculobullous skin disease, and has symptoms including exanthema, pruritus and enanthema. An important gene associated with Skin Disease is COL7A1 (Collagen Type VII Alpha 1 Chain), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Benzocaine and Acitretin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and breast, and related phenotypes are craniofacial and integument

Sources

Related Diseases for Skin Disease

About this section

Diseases related to Skin Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 315)
# Related Disease Score Top Affiliating Genes
1 bullous skin disease 34.9 COL17A1 DSG1 DSG3 DST
2 vesiculobullous skin disease 34.8 COL17A1 COL7A1 DST KRT14 LAMC2
3 hidradenitis suppurativa 33.4 KRT10 KRT14 TNF
4 neurotic excoriation 33.3 COL17A1 COL7A1 DST
5 pemphigus 33.2 COL17A1 DSG1 DSG3 DST
6 dermatitis 33.2 DSG1 FLG IL4 SPINK5
7 bullous pemphigoid 33.0 COL17A1 DSG1 DSG3 DST LAMC2
8 dermatitis, atopic 33.0 FLG IL4 LOR SPINK5 TNF
9 tungiasis 33.0 IL4 TNF
10 epidermolytic hyperkeratosis 32.9 FLG KRT1 KRT10 LOR
11 psoriasis 32.9 CDSN FLG IL4 KRT10 KRT14 LOR
12 epidermolysis bullosa 32.9 COL17A1 COL7A1 DST KRT14 LAMC2
13 herpes gestationis 32.6 COL17A1 DST
14 ichthyosis 32.6 ABCA12 FLG KRT1 KRT10 LOR SPINK5
15 cicatricial pemphigoid 32.5 COL17A1 DST LAMC2
16 keratosis 32.4 DSG1 FLG KRT1 KRT10
17 pemphigoid gestationis 32.4 COL17A1 DST
18 white sponge nevus 1 32.4 KRT1 KRT10 KRT14
19 linear iga disease 32.3 COL17A1 DST
20 contact dermatitis 32.2 FLG IL4 TNF
21 allergic contact dermatitis 32.1 FLG IL4 TNF
22 palmoplantar keratosis 31.1 DSG1 GJB3 KRT1 LOR
23 pemphigus vulgaris 31.1 DSG1 DSG3 DST
24 striate palmoplantar keratoderma 31.1 DSG1 KRT1 KRT10 KRT14
25 hidradenitis 31.1 KRT10 KRT14 TNF
26 netherton syndrome 31.0 DSG1 FLG SPINK5 TGM1
27 pemphigus foliaceus 31.0 DSG1 DSG3 DST
28 paraneoplastic pemphigus 30.9 COL17A1 DSG1 DSG3 DST
29 erythrokeratodermia variabilis et progressiva 1 30.9 GJB3 GJB4 LOR
30 ichthyosis, congenital, autosomal recessive 4b 30.8 ABCA12 FLG TGM1
31 autoimmune disease 30.6 COL17A1 DSG1 IL4 TNF
32 ichthyosis vulgaris 30.4 ABCA12 FLG KRT1 KRT10 KRT14 LOR
33 vohwinkel syndrome 30.1 LOR TGM1
34 granulomatous slack skin disease 12.1
35 vascular skin disease 11.8
36 degos 'en cocarde' erythrokeratoderma 11.5
37 keratolytic winter erythema 11.4
38 herpetiform pemphigus 11.4 DSG1 DSG3 DST
39 pseudoainhum 11.3 GJB3 GJB4 LOR
40 autoimmune disease of skin and connective tissue 11.3 COL17A1 DSG1 DST
41 epidermolysis bullosa acquisita 11.3 COL17A1 COL7A1 DST
42 epidermolysis bullosa, junctional, non-herlitz type 11.3 COL17A1 COL7A1 DST LAMC2
43 subcorneal pustular dermatosis 11.3 COL17A1 DSG1 DSG3 DST
44 epidermolysis bullosa dystrophica 11.3 COL7A1 DST FLG
45 hypotrichosis-deafness syndrome 11.3 GJB3 GJB4
46 tropical endomyocardial fibrosis 11.3 IL4 TNF
47 filamentary keratitis 11.3 FLG KRT1 KRT10
48 orofacial granulomatosis 11.3 FLG IL4 TNF
49 junctional epidermolysis bullosa 11.3 COL17A1 DST LAMC2
50 keratoacanthoma 11.3 DSG1 FLG KRT10

Graphical network of the top 20 diseases related to Skin Disease:



Diseases related to Skin Disease
Sources

Symptoms & Phenotypes for Skin Disease

About this section

UMLS symptoms related to Skin Disease:


exanthema, pruritus, enanthema, skin manifestations, dry skin, nasal itching

MGI Mouse Phenotypes related to Skin Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.5 ABCA12 COL7A1 DSG3 IL4 KRT14 LAMC2
2 integument MP:0010771 9.4 ABCA12 COL7A1 DSG1 DSG3 GJB3 IL4
Sources

Drugs & Therapeutics for Skin Disease

About this section

Drugs for Skin Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1335)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
2
Acitretin Approved Phase 4,Phase 3,Phase 2,Not Applicable 55079-83-9 6437841 5284513
3
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 104987-11-3 445643 439492
4
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-84-3 187
5
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 657-24-9 14219 4091
6
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 64-17-5 702
7
Petrolatum Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 8009-03-8
8 Titanium dioxide Approved Phase 4,Phase 2,Not Applicable 13463-67-7
9
Ustekinumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 815610-63-0
10
Desonide Approved, Investigational Phase 4,Phase 3,Not Applicable 638-94-8 5311066
11
Esomeprazole Approved, Investigational Phase 4,Phase 1 161796-78-7, 119141-88-7 4594 9579578
12
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 185243-69-0
13
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
14
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
15
Amorolfine Approved, Investigational Phase 4,Phase 3 78613-35-1
16
Ciclopirox Approved, Investigational Phase 4,Phase 3,Not Applicable 29342-05-0 2749
17
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
18
Infliximab Approved Phase 4,Phase 3,Phase 2,Not Applicable 170277-31-3
19
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 55-56-1 9552079 2713
20
Phenol Approved, Experimental Phase 4,Not Applicable 108-95-2 996
21
Clindamycin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 18323-44-9 29029
22
Clobetasol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 25122-46-7, 25122-41-2 32798 5311051
23
Glycerol Approved, Investigational Phase 4,Phase 1,Not Applicable 56-81-5 753
24
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 124-94-7 31307
25
Aminolevulinic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 106-60-5 137
26
Isotretinoin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 4759-48-2 5538 5282379
27
Salicylic acid Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 69-72-7 338
28
Fexofenadine Approved, Investigational Phase 4,Phase 2 83799-24-0 3348
29
Gabapentin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 60142-96-3 3446
30
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75614-87-8, 51-45-6 774
31
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
32
Adapalene Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 106685-40-9 60164
33
Benzoyl peroxide Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 94-36-0 7187
34
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 99011-02-6 57469
35
Bosentan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147536-97-8 104865
36
Hydroquinone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 123-31-9 785
37
Fluticasone Approved, Experimental, Investigational Phase 4,Not Applicable 90566-53-3 62924
38
Pimecrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137071-32-0 6447131 17753757
39
Azelaic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 123-99-9 2266
40
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2216-51-5 16666
41
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-66-6 23994
42
Zinc oxide Approved Phase 4,Phase 3,Phase 2,Not Applicable 1314-13-2
43
Coal tar Approved Phase 4,Phase 3,Not Applicable 8007-45-2
44
Iron Approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 7439-89-6 23925
45
Iodine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 7553-56-2 807
46
Povidone Approved Phase 4,Phase 3,Phase 2,Not Applicable 9003-39-8
47
Povidone-iodine Approved Phase 4,Phase 3,Not Applicable 25655-41-8
48
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 41575-94-4 10339178 498142 38904
49
Epirubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 56420-45-2 41867
50
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33069-62-4 36314

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 Weight Reduction Alone May Not be Sufficient to Maintain Disease Remission in Obese Patients With Psoriasis Unknown status NCT01439425 Phase 4
2 Low-Dose (17.5 mg/Day) Acitretin: Comparable Efficacy Without the Side Effects? Unknown status NCT01228409 Phase 4 Acitretin 17.5 mg/day
3 Comparison of Efficacy and Safety of 0.1% Tacrolimus and 0.1% Mometasone Furoate for Adult Vitiligo Unknown status NCT01333410 Phase 4 tacrolimus ointment;Mometasone furoate
4 The Use of Botulinum Toxin A in Two-Stage Tissue Expander/ Implant Breast Reconstruction Unknown status NCT01427400 Phase 4 Botulinum Toxin-A;Saline
5 Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity Unknown status NCT02438020 Phase 4 Metformin
6 Mometasone Furoate Cream Reduces Acute Radiation Dermatitis in Head and Neck Squamous Cell Carcinomas' Patients Unknown status NCT02495064 Phase 4 Mometasone Furoate Cream
7 The Difference of Microparticles in Patients With Psoriasis Vulgaris Who Received Stelara(Ustekinumab) Unknown status NCT02693470 Phase 4 Ustekinumab
8 Proton Pump Inhibitors Use in Patients With Psoriasis Unknown status NCT02624544 Phase 4 esomeprazole;desonide
9 Optimizing Psoriasis Treatment of Etanercept Combined Methotrexate Unknown status NCT02313922 Phase 4 etanercept combined with methotrexate or etanercept combined with placebo
10 Quality of Life of Patients With Psoriasis Treated With Methotrexate: Prospective, Randomized, Double-blind, Parallel Group Study. Unknown status NCT02248792 Phase 4 Methotrexate
11 Effects of Treatment With Biological Agents on Vascular and Cardiac Function in Psoriasis Unknown status NCT02144857 Phase 4 etanercept;ustekinumab;cyclosporine
12 A Study to Evaluate the Effectiveness of STELARA â„¢ (USTEKINUMAB) in the Treatment of Scalp Psoriasis Unknown status NCT01558310 Phase 4 Ustekinumab;Placebo
13 Study Evaluating the Efficacy and Safety of Triptergium Wilfordii and Acitretin in Psoriasis Vulgaris - CHINA201002016-2 Unknown status NCT01443338 Phase 4 Triptergium Wilfordii;Acitretin
14 Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer in Dermatophytic Onychomycosis Unknown status NCT01014637 Phase 4 Amorolfine (Antifungal);RV4104A, Ciclopiroxolamine, Cyclopirox (Keratolytic Agents/Antifungal)
15 Evaluation of Lymphocytic Infiltrate, Dendritic Cells and Cytokines Expression in Psoriatic Lesion and Normal Skin Before and After TNF Alfa Inhibitors Therapy Unknown status NCT01237262 Phase 4 Adalimumab, etanercept, infliximab
16 An Open-label Study to Evaluate the Efficacy of Re-treatment for Patients With a History of Etanercept Use Unknown status NCT01132235 Phase 4
17 Combining Acitretin and Efalizumab in the Therapy of Chronic Plaque Psoriasis Unknown status NCT00707070 Phase 4 efalizumab plus placebo;efalizumab plus acitretin
18 Home UVB Phototherapy for Psoriasis: Effectiveness, Quality of Life and Cost-Effectiveness Unknown status NCT00150930 Phase 4
19 Effectiveness of Lavage With Alcohol - Chlorhexidine for Chemical Matricectomy Unknown status NCT01844141 Phase 4 70% alcohol;70% alcohol - 0.5% clorhexidine
20 Efficacy & Safety of Clindamycin and Tretinoin in Acne Unknown status NCT01111994 Phase 4 Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel
21 Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation Unknown status NCT00779792 Phase 4 clobetasol;triamcinolone acetonide;tacrolimus;glycerol;vehicle ointment (paraffin oil/soft white paraffin)
22 Superficial Basal Cell Carcinoma Treatment With Topical Photodynamic Therapy With Fractionated 5-aminolevulinic Acid 20% Versus Two Stage Methylaminolevulinate Unknown status NCT01491711 Phase 4 Methylaminolevulinate PDT in 2 sessions;Fractionated 5-aminolevulinic acid hydrochloride 20% gel PDT
23 Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea Unknown status NCT01139749 Phase 4 oral isotretinoin;salicylic acid and ciclopirox olamine
24 Efficacy and Safety of Treatment of Actinic Keratoses With Photodynamic Therapy Between MAL Cream and ALA Gel Unknown status NCT02647151 Phase 4 METHYLAMINOLEVULINATE HYDROCHLORIDE;AMINOLEVULINIC ACID HYDROCHLORIDE
25 Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4 pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
26 Long Term Efficacy and Safety of Eryfotona AK-NMSC® in Patients With Actinic Keratosis Unknown status NCT01656226 Phase 4
27 Pilot Study of Tolerability and Effectivity of Two Combination Topical Acne Products Unknown status NCT02731105 Phase 4 Acnatac® Gel left face;Epiduo® Gel right face;Acnatac® Gel right face;Epiduo® Gel left face
28 Potential Effect of Topical Imiquimod on Atrial Ectopy in Patients With Actinic Keratosis Unknown status NCT01413763 Phase 4 Imiquimod cream 3.75%;Placebo cream
29 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
30 Safety and Tolerability of Acanya Gel in Combination With Atralin Gel for Acne Vulgaris Unknown status NCT01448733 Phase 4 Benzoyl peroxide 2.5%/clindamycin phosphate 1.2% in the morning with with tretinoin 0.05% gel in the evening
31 A Study Comparing Combination Clindamycin Phosphate/Tretinoin Gel Alone Versus With Benzoyl Peroxide Foaming Cloths for Facial Acne Unknown status NCT01422785 Phase 4 clindamycin phosphate 1.2%/tretinoin 0.025% gel alone;clindamycin phosphate 1.2%/tretinoin 0.025% gel plus benzoyl peroxide 6% foaming cloths
32 The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis Unknown status NCT02480335 Phase 4 bosentan
33 Clinical Study to Evaluate the Efficacy of Topical Medications Containing Benzoyl Peroxide and Sulfur in the Regression in the Short Time (24 Hours) of Moderate Acne Vulgaris Grade II (Pimples) Unknown status NCT01260571 Phase 4 Benzoyl peroxide and sulfur
34 Wound Management for Sacral Pressure Ulcers With Necrotic Tissue Unknown status NCT02224638 Phase 4
35 Efficacy of Quantum NPWT With Simultaneous Irrigation on Reduction of Wound Volume in Stage III/IV Pressure Ulcers. Unknown status NCT01734109 Phase 4
36 Clinical Trial of Hydroquinone Versus Miconazol in Melasma Unknown status NCT01661556 Phase 4 Miconazole;Hydroquinone
37 Olive Oil's Cream Effectiveness in Prevention of Pressure Ulcers in Immobilized Patients in Primary Care Unknown status NCT01595347 Phase 4 Hyper-oxigenated fatty acid
38 Effect of Fluticasone Proprionate 0.05% on Narrow Band UV-B in Active Vitiligo Unknown status NCT01246921 Phase 4 Fluticasone proprionate 0.05% cream
39 Vitiligo and the Koebner Phenomenon (Model of Vitiligo Induction and Therapy: a Clinical and Immunological Analysis) Unknown status NCT01082393 Phase 4 topical tacrolimus treatment;topical pimecrolimus treatment;local mometasone furoate treatment;cold cream
40 Azelaic Acid Versus Hydroquinone in Melasma Unknown status NCT00927771 Phase 4 azelaic acid gel;hydroquinone cream
41 Trial Comparing Calmoseptine Ointment and Desitin Diaper Rash Paste in Diaper Dermatitis in Neonates and Infants Unknown status NCT02716415 Phase 4 Calmoseptine Ointment;Destin Maximum Strength 40% Zinc
42 Study on the Effects of Oxygen-ozone Therapy on Back Pain in Subjects Aged 65 or Older Unknown status NCT01709058 Phase 4 Intramuscular/paravertebral injections of Oxygen-Ozone
43 Imiquimod 3.75% Cream in Combination With Cryotherapy in the Treatment of Hypertrophic Actinic Keratoses Unknown status NCT01229319 Phase 4 Cryotherapy alone to Left arm plus cryotherapy + imiquimod to Right arm;Cryotherapy alone to Left arm plus cryotherapy + imiquimod to Right arm
44 Sienna+® Injection Time Study 4 Arms Unknown status NCT02612870 Phase 4
45 Wound Infections in Breast Cancer Surgery After Preoperative Skin Preparation With Chlorhexidine vs. Povidone-iodine Unknown status NCT02479347 Phase 4 Chlorhexidine;Povidone-Iodine
46 Paclitaxel in Combination With Carboplatin Versus Paclitaxel Plus Epirubicin in Metastatic Breast Cancer Unknown status NCT02207361 Phase 4 Paclitaxel, Carboplatin;Paclitaxel, Epirubicin
47 Weekly and Every 3 Week Administration of Paclitaxel Liposome Injection in Metastatic Breast Cancer Unknown status NCT02142790 Phase 4 paclitaxel liposome injection
48 Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in Alopecia Unknown status NCT01111981 Phase 4 Clobetasol Propionate 0.05% Emollient Foam
49 Proton MR Spectroscopy and 18F-Fluorocholine PET for Breast Cancer Diagnosis Unknown status NCT01956409 Phase 4 18F-FCH;Magnevist
50 Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy (PreFace) Unknown status NCT01908556 Phase 4 Letrozole

Search NIH Clinical Center for Skin Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Skin Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Skin Disease:
JACE
Embryonic/Adult Cultured Cells Related to Skin Disease:
Cultured epidermis (JACE PMIDs: 23265935 17465819 11987545

Cochrane evidence based reviews: skin diseases

Sources

Genetic Tests for Skin Disease

About this section

Genetic tests related to Skin Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Skin 29
Sources

Anatomical Context for Skin Disease

About this section

The Foundational Model of Anatomy Ontology organs/tissues related to Skin Disease:

19
Skin

MalaCards organs/tissues related to Skin Disease:

41
Skin, Breast, Testes, Lymph Node, Bone, T Cells, Brain
Sources

Publications for Skin Disease

About this section

Articles related to Skin Disease:

(show top 50) (show all 900)
# Title Authors Year
1
Simplifying Skin Disease Diagnosis with Topical Nanotechnology. ( 29772963 )
2018
2
Pustular psoriasis and related pustular skin diseases. ( 29333670 )
2018
3
Miscellaneous skin disease and the metabolic syndrome. ( 29241760 )
2018
4
Skin disease prevalence study in schoolchildren in rural CA'te d'Ivoire: Implications for integration of neglected skin diseases (skin NTDs). ( 29771976 )
2018
5
Molecular characterization of lumpy skin disease virus in Namibia, 2017. ( 29869033 )
2018
6
The impact of pediatric skin disease on self-esteem. ( 29872673 )
2018
7
Neuromodulation in Inflammatory Skin Disease. ( 29427206 )
2018
8
Serological and clinical evaluation of the Yugoslavian RM65 sheep pox strain vaccine use in cattle against lumpy skin disease. ( 29873893 )
2018
9
Aryl hydrocarbon receptor (AhR) a possible target for the treatment of skin disease. ( 29857917 )
2018
10
Identification and characterization of lumpy skin disease virus isolated from cattle in the Republic of North Ossetia-Alania in 2015. ( 29363284 )
2018
11
Gaps in Workplace Education For Prevention of Occupational Skin Disease. ( 29220520 )
2018
12
Epidemiology of tattoo skin disease in captive common bottlenose dolphins (Tursiops truncatus): Are males more vulnerable than females? ( 29353509 )
2018
13
Owner-reported flea treatment measures and skin disease in cats. ( 29788829 )
2018
14
Cytokine Targeted Therapeutics forA Alopecia Areata: Lessons fromA Atopic Dermatitis and OtherA Inflammatory Skin Diseases. ( 29273110 )
2018
15
Correction: PAMs ameliorates the imiquimod-induced psoriasis-like skin disease in mice by inhibition of translocation of NF-I_B and production of inflammatory cytokines. ( 29847604 )
2018
16
Spatial and temporal distribution of lumpy skin disease outbreaks in Uganda (2002-2016). ( 29859091 )
2018
17
Epithelial proliferation in inflammatory skin disease is regulated by tetratricopeptide repeat domain 7 (Ttc7) in fibroblasts and lymphocytes. ( 29775636 )
2018
18
Wild primates threaten efforts to wipe out skin disease. ( 29446404 )
2018
19
Inflammation: A Contributor to Depressive Comorbidity in Inflammatory Skin Disease. ( 29953999 )
2018
20
Malnutrition and skin disease in Far East prisoners-of-war in World War II. ( 29855062 )
2018
21
Characterisation of putative immunomodulatory gene knockouts of lumpy skin disease virus in cattle towards an improved vaccine. ( 29941325 )
2018
22
Phylogenetic analysis of the lumpy skin disease viruses in northwest of Iran. ( 29948777 )
2018
23
Skin Gene Expression Is Prognostic for the Trajectory of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis. ( 29858547 )
2018
24
Risk of introduction of lumpy skin disease in France by the import of vectors in animal trucks. ( 29889905 )
2018
25
Neonatal Phototherapy: A Novel Therapy to Prevent Allergic Skin Disease for At Least 5 Years. ( 29940600 )
2018
26
Skin and Diet: An Update on the Role of Dietary Change as a Treatment Strategy for Skin Disease. ( 29357214 )
2018
27
Detection of vaccine-like lumpy skin disease virus in cattle and Musca domestica L. flies in an outbreak of lumpy skin disease in Russia in 2017. ( 29932512 )
2018
28
Complete Genome Sequence of a Lumpy Skin Disease Virus Strain Isolated from the Skin of a Vaccinated Animal. ( 29853513 )
2018
29
Skin disease in captive bats: results of an online survey of zoos and rehabilitators in Europe, North America and Australasia. ( 28044386 )
2017
30
Investigation on the incidence of adverse reactions, viraemia and haematological changes following field immunization of cattle using a live attenuated vaccine against lumpy skin disease. ( 28391652 )
2017
31
The Molecular Revolution in Cutaneous Biology: Identification of Skin Disease Genes. ( 28411848 )
2017
32
Advances in the Application and Impact of MicroRNAs as Therapies for Skin Disease. ( 28875300 )
2017
33
The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds). ( 28904532 )
2017
34
Severe Mucha-Habermann-Like Ulceronecrotic Skin Disease in T-Cell Acute Lymphoblastic Leukemia Responsive to Basiliximab and Stem Cell Transplant. ( 28884915 )
2017
35
Translation and Validation of the Serbian Version of the Skindex-29 Instrument for Measuring Impact of Skin Disease on Quality of Life. ( 28871926 )
2017
36
Skin biopsy in the diagnosis of inflammatory skin disease. ( 28472573 )
2017
37
Skin Disease as Art. ( 28492841 )
2017
38
Analogs of human genetic skin disease in domesticated animals. ( 28831430 )
2017
39
Complete Genome Sequence of the Lumpy Skin Disease Virus Isolated from the First Reported Case in Greece in 2015. ( 28729259 )
2017
40
Lumpy skin disease outbreaks in Greece during 2015-16, implementation of emergency immunization and genetic differentiation between field isolates and vaccine virus strains. ( 28284627 )
2017
41
Prediction and benefits of minimal disease activity in patients with psoriatic arthritis and active skin disease in the ADEPT trial. ( 29225916 )
2017
42
Vitiligo: Not Simply a Skin Disease. ( 28528606 )
2017
43
Bacterial diversity in Buruli ulcer skin lesions: Challenges in the clinical microbiome analysis of a skin disease. ( 28750103 )
2017
44
Effective Collaboration on Skin Disease Starts With Medical Education. ( 28350601 )
2017
45
Knowledge, attitudes and practices towards yaws and yaws-like skin disease in Ghana. ( 28759580 )
2017
46
Skin diseases in indigenous population: retrospective epidemiological study at Xingu Indigenous Park (XIP) and review of the literature. ( 28791692 )
2017
47
Economic impact of lumpy skin disease and cost effectiveness of vaccination for the control of outbreaks in Ethiopia. ( 29254706 )
2017
48
Laser treatment of medical skin disease in women. ( 28831422 )
2017
49
Phenotypic analysis of circulating T-cell subset and its association with burden of skin disease in patients with chronic actinic dermatitis: a hematologic and clinicopathologic study of 20 subjects. ( 28176301 )
2017
50
PAMs ameliorates the imiquimod-induced psoriasis-like skin disease in mice by inhibition of translocation of NF-I_B and production of inflammatory cytokines. ( 28464025 )
2017
Sources

Variations for Skin Disease

About this section

ClinVar genetic disease variations for Skin Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 COL7A1 NM_000094.3(COL7A1): c.425A> G (p.Lys142Arg) single nucleotide variant Pathogenic rs121912856 GRCh37 Chromosome 3, 48630971: 48630971
2 COL7A1 NM_000094.3(COL7A1): c.425A> G (p.Lys142Arg) single nucleotide variant Pathogenic rs121912856 GRCh38 Chromosome 3, 48593538: 48593538
3 COL7A1 NM_000094.3(COL7A1): c.2005C> T (p.Arg669Ter) single nucleotide variant Pathogenic rs780261665 GRCh37 Chromosome 3, 48627691: 48627691
4 COL7A1 NM_000094.3(COL7A1): c.2005C> T (p.Arg669Ter) single nucleotide variant Pathogenic rs780261665 GRCh38 Chromosome 3, 48590258: 48590258
5 FLG NM_002016.1(FLG): c.544A> T (p.Lys182Ter) single nucleotide variant Pathogenic GRCh38 Chromosome 1, 152314342: 152314342
6 FLG NM_002016.1(FLG): c.544A> T (p.Lys182Ter) single nucleotide variant Pathogenic GRCh37 Chromosome 1, 152286818: 152286818
7 KRT1 NM_006121.3(KRT1): c.744T> A (p.Asp248Glu) single nucleotide variant Uncertain significance GRCh37 Chromosome 12, 53072388: 53072388
8 KRT1 NM_006121.3(KRT1): c.744T> A (p.Asp248Glu) single nucleotide variant Uncertain significance GRCh38 Chromosome 12, 52678604: 52678604
Sources

Expression for Skin Disease

About this section
Search GEO for disease gene expression data for Skin Disease.
Sources

Pathways for Skin Disease

About this section

Pathways related to Skin Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Developmental Biology 66
Show member pathways
 12.91 CDSN DSG1 DSG3 FLG KRT1 KRT10
2
Keratinization 66
Show member pathways
 11.78 CDSN DSG1 DSG3 FLG KRT1 KRT10
3
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 11.37 DST KRT1 KRT14
Sources

GO Terms for Skin Disease

About this section

Cellular components related to Skin Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.91 COL17A1 DSG1 DSG3 DST GJB3 GJB4
2 cell-cell junction GO:0005911 9.67 CDSN COL17A1 DSG1 GJB3
3 basement membrane GO:0005604 9.46 COL17A1 COL7A1 DST LAMC2
4 desmosome GO:0030057 9.43 CDSN DSG1 DSG3
5 hemidesmosome GO:0030056 9.4 COL17A1 DST
6 intermediate filament GO:0005882 9.35 DST FLG KRT1 KRT10 KRT14
7 epidermal lamellar body GO:0097209 9.32 ABCA12 SPINK5
8 cornified envelope GO:0001533 9.23 CDSN DSG1 DSG3 FLG KRT1 KRT10

Biological processes related to Skin Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.88 CDSN COL7A1 DSG1 DSG3 DST LAMC2
2 extracellular matrix organization GO:0030198 9.73 COL7A1 LAMC2 SPINK5 TNF
3 epidermis development GO:0008544 9.73 CDSN COL17A1 COL7A1 FLG KRT14 LAMC2
4 peptide cross-linking GO:0018149 9.72 FLG KRT1 KRT10 LOR TGM1
5 keratinocyte differentiation GO:0030216 9.63 ABCA12 CDSN FLG KRT10 LOR TGM1
6 keratinization GO:0031424 9.56 ABCA12 DSG1 DSG3 KRT1 KRT10 KRT14
7 hemidesmosome assembly GO:0031581 9.54 COL17A1 KRT14 LAMC2
8 establishment of skin barrier GO:0061436 9.48 ABCA12 FLG
9 positive regulation of protein localization to cell surface GO:2000010 9.46 ABCA12 TNF
10 cornification GO:0070268 9.32 CDSN DSG1 DSG3 FLG KRT1 KRT10

Molecular functions related to Skin Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.26 FLG KRT1 KRT10 LOR
2 structural constituent of epidermis GO:0030280 8.92 FLG KRT1 KRT10 LOR
Sources

Sources for Skin Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....