MCID: SKN018
MIFTS: 39

Skin Hemangioma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Skin Hemangioma

MalaCards integrated aliases for Skin Hemangioma:

Name: Skin Hemangioma 12 15
Angiomatous Naevus of Skin 12
Angioma of the Skin 12
Hemangioma of Skin 73

Classifications:



External Ids:

Disease Ontology 12 DOID:471
NCIt 50 C4905
UMLS 73 C0687140

Summaries for Skin Hemangioma

MalaCards based summary : Skin Hemangioma, also known as angiomatous naevus of skin, is related to angioma serpiginosum and hemangioma. An important gene associated with Skin Hemangioma is SLC2A1 (Solute Carrier Family 2 Member 1), and among its related pathways/superpathways are Development VEGF signaling via VEGFR2 - generic cascades and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Ephedrine and Timolol have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and eye, and related phenotypes are immune system and digestive/alimentary

Related Diseases for Skin Hemangioma

Diseases related to Skin Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 angioma serpiginosum 31.9 PORCN RASA1
2 hemangioma 29.8 KDR PROX1 SLC2A1 VEGFA
3 capillary hemangioma 29.7 HBA1 KDR PROX1 RASA1 SLC2A1 VEGFA
4 pediatric angiosarcoma 10.6 HBA1 VEGFA
5 hypoglycemic coma 10.6 HBA1 VEGFA
6 glomeruloid hemangioma 10.6 HBA1 VEGFA
7 renal pelvis carcinoma 10.6 SLC2A1 VEGFA
8 cardiovascular organ benign neoplasm 10.5 HBA1 SLC2A1
9 benign perivascular tumor 10.5 HBA1 SLC2A1
10 senile angioma 10.5 HBA1 KDR
11 capillary lymphangioma 10.5 HBA1 PROX1
12 acquired hemangioma 10.5 HBA1 PROX1
13 angiokeratoma of fordyce 10.5 HBA1 PROX1
14 glomangioma 10.5 HBA1 SLC2A1
15 interstitial emphysema 10.4 HBA1 PROX1
16 radiation proctitis 10.4 KDR VEGFA
17 telangiectasis 10.4 RASA1 VEGFA
18 epithelioid hemangioendothelioma 10.4 KDR VEGFA
19 kuhnt-junius degeneration 10.4 KDR VEGFA
20 acute hemorrhagic leukoencephalitis 10.4 KDR VEGFA
21 leukostasis 10.4 KDR VEGFA
22 kaposiform hemangioendothelioma 10.3 KDR PROX1
23 coats disease 10.3 KDR VEGFA
24 arteriovenous malformation 10.3 RASA1 VEGFA
25 degeneration of macula and posterior pole 10.2 KDR VEGFA
26 epileptic encephalopathy, childhood-onset 10.2 KDR VEGFA
27 connective tissue cancer 10.2 HBA1 VEGFA
28 breast carcinoma in situ 10.1 KDR VEGFA
29 angiomatous meningioma 10.1 HBA1 KDR VEGFA
30 vascular cancer 10.1 HBA1 KDR VEGFA
31 clear cell renal cell carcinoma 10.1 KDR SLC2A1 VEGFA
32 retinal vascular disease 10.1 HBA1 KDR VEGFA
33 arteriovenous malformations of the brain 10.1 KDR RASA1 VEGFA
34 lymphangiosarcoma 10.1 HBA1 PROX1 VEGFA
35 corneal neovascularization 10.0 KDR VEGFA
36 angiosarcoma 10.0 KDR PROX1 VEGFA
37 fucosidosis 10.0 FUCA1 NAGA
38 limb ischemia 9.9 KDR VEGFA
39 mannosidosis 9.8 MANBA NAGA
40 angiokeratoma circumscriptum 9.8 KDR RASA1 SLC2A1 VEGFA
41 fabry disease 9.7 FUCA1 GLA NAGA
42 mannosidosis, beta a, lysosomal 9.7 MANBA NAGA
43 placental insufficiency 9.7 KDR VEGFA
44 lymphangioma 9.6 HBA1 KDR PROX1 VEGFA
45 breast cancer 9.6
46 sturge-weber syndrome 9.6
47 leukemia 9.6
48 thyroid cancer 9.6
49 melanoma 9.6
50 thyroiditis 9.6

Graphical network of the top 20 diseases related to Skin Hemangioma:



Diseases related to Skin Hemangioma

Symptoms & Phenotypes for Skin Hemangioma

MGI Mouse Phenotypes related to Skin Hemangioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 RASA1 VEGFA GLA KDR MANBA NAGA
2 digestive/alimentary MP:0005381 9.65 PROX1 RASA1 VEGFA MANBA PORCN
3 liver/biliary system MP:0005370 9.35 VEGFA GLA KDR MANBA PROX1
4 nervous system MP:0003631 9.23 RASA1 SLC2A1 VEGFA GLA KDR MANBA

Drugs & Therapeutics for Skin Hemangioma

Drugs for Skin Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ephedrine Approved Phase 3 299-42-3 9294
2
Timolol Approved Phase 3 26839-75-8 33624 5478
3
Pseudoephedrine Approved Phase 3 90-82-4 7028
4
Maleic acid Experimental Phase 3 110-16-7 444266
5 Respiratory System Agents Phase 3
6 Adrenergic Agents Phase 3
7 Adrenergic Antagonists Phase 3
8 Adrenergic beta-Antagonists Phase 3
9 Nasal Decongestants Phase 3
10 Neurotransmitter Agents Phase 3
11 Tetrahydrozoline Phase 3
12 Ophthalmic Solutions Phase 3
13 Vasoconstrictor Agents Phase 3
14 Anti-Arrhythmia Agents Phase 3
15 Peripheral Nervous System Agents Phase 3
16 Pharmaceutical Solutions Phase 3
17 Antihypertensive Agents Phase 3
18 Autonomic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Timolol for Superficial Infantile Hemangioma Unknown status NCT01685398 Phase 3 0.5% timolol maleate eye drop;Normal saline
2 Long Term Neurocognitive Effects of Low-dose Radiation in the Brain: Study of 150 Patients in the French Hemangioma Cohort Unknown status NCT01960751 Not Applicable
3 Incidence of Hepatic Hemangiomatosis in Patients With Cutaneous Hemangiomas Completed NCT00374335 Not Applicable

Search NIH Clinical Center for Skin Hemangioma

Genetic Tests for Skin Hemangioma

Anatomical Context for Skin Hemangioma

MalaCards organs/tissues related to Skin Hemangioma:

41
Skin, Brain, Eye, Thyroid

Publications for Skin Hemangioma

Articles related to Skin Hemangioma:

(show all 17)
# Title Authors Year
1
The expression and function of miR-424 in infantile skin hemangioma and its mechanism. ( 28928430 )
2017
2
New dosimetry for childhood skin hemangioma treatments with (226)Ra needles or tubes. ( 26104976 )
2015
3
Radiotherapy as a risk factor for malignant melanoma after childhood skin hemangioma. ( 22082956 )
2012
4
Contribution of skin trauma to infantile skin hemangioma. ( 21220189 )
2011
5
Cancer mortality after radiotherapy for a skin hemangioma during childhood. ( 15236880 )
2004
6
Oral giant pyogenic granulomas associated with facial skin hemangiomas (Sturge-Weber syndrome). ( 10860035 )
1999
7
Outcome of reproduction in women irradiated for skin hemangioma in infancy. ( 9457901 )
1998
8
Intracranial tumors after exposure to ionizing radiation during infancy: a pooled analysis of two Swedish cohorts of 28,008 infants with skin hemangioma. ( 9728664 )
1998
9
Intracranial tumors after radium treatment for skin hemangioma during infancy--a cohort and case-control study. ( 9254735 )
1997
10
Breast cancer after radiotherapy for skin hemangioma in infancy. ( 8606933 )
1996
11
Mortality from leukemia after irradiation in infancy for skin hemangioma. ( 8619025 )
1996
12
Thyroid cancer after radiotherapy for skin hemangioma in infancy. ( 7972685 )
1994
13
Tumors after radiotherapy for skin hemangioma in childhood. A case-control study. ( 2206565 )
1990
14
Cancer incidence after radiotherapy for skin hemangioma: a retrospective cohort study in Sweden. ( 3172265 )
1988
15
[Treatment of skin hemangioma with 90 Sr beta-ray]. ( 988315 )
1976
16
Skin hemangioma and retrolental fibroplasia. ( 13312656 )
1956
17
Skin hemangioma and retrolental fibroplasia. ( 13079298 )
1953

Variations for Skin Hemangioma

Expression for Skin Hemangioma

Search GEO for disease gene expression data for Skin Hemangioma.

Pathways for Skin Hemangioma

Pathways related to Skin Hemangioma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.06 KDR RASA1 VEGFA
2 11.67 KDR PROX1 VEGFA
3
Show member pathways
11.49 KDR RASA1 VEGFA
4
Show member pathways
11.3 KDR RASA1 VEGFA
5 11.24 KDR VEGFA
6 11.2 KDR VEGFA
7
Show member pathways
11.15 KDR VEGFA
8 11.13 KDR VEGFA
9
Show member pathways
11.05 GLA NAGA
10 11.02 SLC2A1 VEGFA
11 11.01 FUCA1 GLA MANBA NAGA
12 10.81 KDR VEGFA
13 10.66 FUCA1 MANBA
14 10.66 KDR SLC2A1 VEGFA
15
Show member pathways
10.53 KDR VEGFA

GO Terms for Skin Hemangioma

Cellular components related to Skin Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 9.26 FUCA1 GLA MANBA NAGA
2 lysosomal lumen GO:0043202 8.8 FUCA1 GLA MANBA

Biological processes related to Skin Hemangioma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 metabolic process GO:0008152 9.81 FUCA1 GLA MANBA NAGA
2 carbohydrate metabolic process GO:0005975 9.71 FUCA1 GLA MANBA NAGA
3 regulation of cell shape GO:0008360 9.67 KDR RASA1 VEGFA
4 positive regulation of endothelial cell proliferation GO:0001938 9.61 KDR PROX1 VEGFA
5 positive regulation of blood vessel endothelial cell migration GO:0043536 9.57 KDR VEGFA
6 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.56 KDR VEGFA
7 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.55 KDR VEGFA
8 oligosaccharide metabolic process GO:0009311 9.54 GLA NAGA
9 vasculogenesis GO:0001570 9.54 KDR RASA1 VEGFA
10 positive regulation of focal adhesion assembly GO:0051894 9.52 KDR VEGFA
11 cell migration involved in sprouting angiogenesis GO:0002042 9.48 KDR VEGFA
12 positive regulation of positive chemotaxis GO:0050927 9.46 KDR VEGFA
13 positive regulation of endothelial cell migration GO:0010595 9.43 KDR PROX1 VEGFA
14 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.32 KDR VEGFA
15 glycosylceramide catabolic process GO:0046477 9.16 GLA NAGA
16 glycolipid catabolic process GO:0019377 8.96 FUCA1 NAGA
17 glycoside catabolic process GO:0016139 8.8 FUCA1 GLA NAGA

Molecular functions related to Skin Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.16 GLA NAGA
2 alpha-galactosidase activity GO:0004557 8.96 GLA NAGA
3 hydrolase activity, acting on glycosyl bonds GO:0016798 8.92 FUCA1 GLA MANBA NAGA

Sources for Skin Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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