MCID: SKN018
MIFTS: 36

Skin Hemangioma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Skin Hemangioma

MalaCards integrated aliases for Skin Hemangioma:

Name: Skin Hemangioma 12 15
Angiomatous Naevus of Skin 12
Angioma of the Skin 12
Hemangioma of Skin 73

Classifications:



External Ids:

Disease Ontology 12 DOID:471
NCIt 50 C4905
SNOMED-CT 68 93471006
UMLS 73 C0687140

Summaries for Skin Hemangioma

MalaCards based summary : Skin Hemangioma, also known as angiomatous naevus of skin, is related to capillary hemangioma and hemangioma. An important gene associated with Skin Hemangioma is SLC2A1 (Solute Carrier Family 2 Member 1), and among its related pathways/superpathways are MAPK signaling pathway and Ras signaling pathway. The drugs Timolol and Maleic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and brain, and related phenotypes are behavior/neurological and cellular

Related Diseases for Skin Hemangioma

Diseases related to Skin Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 capillary hemangioma 31.1 FLT1 HBA1 KDR RASA1 SLC2A1 VEGFA
2 hemangioma 30.0 FLT1 KDR PROX1 SLC2A1 VEGFA
3 angioma serpiginosum 11.0
4 arteriovenous malformation 10.2 RASA1 VEGFA
5 pediatric angiosarcoma 10.2 HBA1 VEGFA
6 hypoglycemic coma 10.2 HBA1 VEGFA
7 renal pelvis carcinoma 10.2 SLC2A1 VEGFA
8 capillary lymphangioma 10.1 HBA1 PROX1
9 acquired hemangioma 10.1 HBA1 PROX1
10 senile angioma 10.1 HBA1 KDR
11 angiokeratoma of fordyce 10.1 HBA1 PROX1
12 radiation proctitis 10.1 KDR VEGFA
13 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.1 RASA1 SLC2A1
14 kaposiform hemangioendothelioma 10.1 KDR PROX1
15 microcystic meningioma 10.1 FLT1 VEGFA
16 leukostasis 10.1 KDR VEGFA
17 lipodermatosclerosis 10.1 FLT1 VEGFA
18 coats disease 10.1 KDR VEGFA
19 cancer-associated retinopathy 10.1 FLT1 VEGFA
20 drug-induced lupus erythematosus 10.0 HBA1 KDR VEGFA
21 angiomatous meningioma 10.0 HBA1 KDR VEGFA
22 arteriovenous malformations of the brain 10.0 KDR RASA1 VEGFA
23 lymphangiosarcoma 10.0 HBA1 PROX1 VEGFA
24 epileptic encephalopathy, childhood-onset 10.0 KDR VEGFA
25 clear cell renal cell carcinoma 10.0 KDR SLC2A1 VEGFA
26 glomeruloid hemangioma 10.0 FLT1 HBA1 VEGFA
27 acute mountain sickness 10.0 FLT1 VEGFA
28 interstitial emphysema 10.0 FLT1 HBA1 PROX1
29 alveoli adenoma 10.0 FLT1 HBA1 PROX1
30 degeneration of macula and posterior pole 10.0 KDR VEGFA
31 epithelioid hemangioendothelioma 10.0 FLT1 KDR VEGFA
32 corneal neovascularization 10.0 FLT1 KDR VEGFA
33 placental insufficiency 10.0 FLT1 KDR VEGFA
34 fucosidosis 9.9 FUCA1 NAGA
35 exudative vitreoretinopathy 1 9.9 FLT1 KDR VEGFA
36 microvascular complications of diabetes 5 9.9 FLT1 KDR VEGFA
37 mannosidosis 9.9 MANBA NAGA
38 fabry disease 9.9 FUCA1 GLA NAGA
39 macular degeneration, age-related, 1 9.9 FLT1 KDR VEGFA
40 breast carcinoma in situ 9.9 KDR VEGFA
41 lymphangioma 9.9 HBA1 KDR PROX1 VEGFA
42 mannosidosis, beta a, lysosomal 9.9 MANBA NAGA
43 retinal vascular disease 9.8 FLT1 HBA1 KDR VEGFA
44 angiosarcoma 9.8 FLT1 KDR PROX1 VEGFA
45 lysosomal storage disease 9.8 FUCA1 GLA MANBA
46 large intestine cancer 9.7 FLT1 HBA1 KDR SLC2A1 VEGFA
47 angiokeratoma circumscriptum 9.7 FLT1 KDR RASA1 SLC2A1 VEGFA
48 breast cancer 9.7
49 sturge-weber syndrome 9.7
50 leukemia 9.7

Graphical network of the top 20 diseases related to Skin Hemangioma:



Diseases related to Skin Hemangioma

Symptoms & Phenotypes for Skin Hemangioma

MGI Mouse Phenotypes related to Skin Hemangioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 FLT1 FUCA1 GLA KDR MANBA PROX1
2 cellular MP:0005384 10.02 FLT1 FUCA1 GLA KDR MANBA PROX1
3 cardiovascular system MP:0005385 9.95 FLT1 GLA KDR MANBA PROX1 RASA1
4 homeostasis/metabolism MP:0005376 9.92 FLT1 FUCA1 GLA KDR NAGA PROX1
5 immune system MP:0005387 9.86 FLT1 GLA KDR MANBA NAGA PROX1
6 liver/biliary system MP:0005370 9.55 GLA KDR MANBA PROX1 VEGFA
7 muscle MP:0005369 9.43 FLT1 GLA KDR PROX1 RASA1 VEGFA
8 nervous system MP:0003631 9.28 FLT1 FUCA1 GLA KDR MANBA PROX1

Drugs & Therapeutics for Skin Hemangioma

Drugs for Skin Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Timolol Approved Phase 3 26839-75-8 33624 5478
2
Maleic acid Experimental Phase 3 110-16-7 444266
3 Ophthalmic Solutions Phase 3
4 Neurotransmitter Agents Phase 3,Phase 2
5 Antihypertensive Agents Phase 3,Phase 2
6 Adrenergic Antagonists Phase 3,Phase 2
7 Adrenergic beta-Antagonists Phase 3,Phase 2
8 Pharmaceutical Solutions Phase 3
9 Adrenergic Agents Phase 3,Phase 2
10 Anti-Arrhythmia Agents Phase 3,Phase 2
11
Propranolol Approved, Investigational Phase 2 525-66-6 4946
12 Vasodilator Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Timolol for Superficial Infantile Hemangioma Unknown status NCT01685398 Phase 3 0.5% timolol maleate eye drop;Normal saline
2 Treat_CCM: Propranolol in Cerebral Cavernous Malformation Recruiting NCT03589014 Phase 2 Propranolol
3 Long Term Neurocognitive Effects of Low-dose Radiation in the Brain: Study of 150 Patients in the French Hemangioma Cohort Unknown status NCT01960751 Not Applicable
4 Incidence of Hepatic Hemangiomatosis in Patients With Cutaneous Hemangiomas Completed NCT00374335 Not Applicable

Search NIH Clinical Center for Skin Hemangioma

Genetic Tests for Skin Hemangioma

Anatomical Context for Skin Hemangioma

MalaCards organs/tissues related to Skin Hemangioma:

41
Skin, Thyroid, Brain

Publications for Skin Hemangioma

Articles related to Skin Hemangioma:

(show all 16)
# Title Authors Year
1
The expression and function of miR-424 in infantile skin hemangioma and its mechanism. ( 28928430 )
2017
2
New dosimetry for childhood skin hemangioma treatments with (226)Ra needles or tubes. ( 26104976 )
2015
3
Radiotherapy as a risk factor for malignant melanoma after childhood skin hemangioma. ( 22082956 )
2012
4
Contribution of skin trauma to infantile skin hemangioma. ( 21220189 )
2011
5
Cancer mortality after radiotherapy for a skin hemangioma during childhood. ( 15236880 )
2004
6
Outcome of reproduction in women irradiated for skin hemangioma in infancy. ( 9457901 )
1998
7
Intracranial tumors after exposure to ionizing radiation during infancy: a pooled analysis of two Swedish cohorts of 28,008 infants with skin hemangioma. ( 9728664 )
1998
8
Intracranial tumors after radium treatment for skin hemangioma during infancy--a cohort and case-control study. ( 9254735 )
1997
9
Breast cancer after radiotherapy for skin hemangioma in infancy. ( 8606933 )
1996
10
Mortality from leukemia after irradiation in infancy for skin hemangioma. ( 8619025 )
1996
11
Thyroid cancer after radiotherapy for skin hemangioma in infancy. ( 7972685 )
1994
12
Tumors after radiotherapy for skin hemangioma in childhood. A case-control study. ( 2206565 )
1990
13
Cancer incidence after radiotherapy for skin hemangioma: a retrospective cohort study in Sweden. ( 3172265 )
1988
14
[Treatment of skin hemangioma with 90 Sr beta-ray]. ( 988315 )
1976
15
Skin hemangioma and retrolental fibroplasia. ( 13312656 )
1956
16
Skin hemangioma and retrolental fibroplasia. ( 13079298 )
1953

Variations for Skin Hemangioma

Expression for Skin Hemangioma

Search GEO for disease gene expression data for Skin Hemangioma.

Pathways for Skin Hemangioma

Pathways related to Skin Hemangioma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1 12.5 FLT1 KDR RASA1 VEGFA
2
Show member pathways
12.45 FLT1 KDR RASA1 VEGFA
3
Show member pathways
12.17 FLT1 KDR VEGFA
4
Show member pathways
12.17 KDR RASA1 VEGFA
5
Show member pathways
12 FLT1 KDR VEGFA
6 11.83 FLT1 KDR VEGFA
7 11.79 KDR PROX1 VEGFA
8
Show member pathways
11.71 KDR RASA1 VEGFA
9 11.71 FUCA1 GLA MANBA NAGA
10
Show member pathways
11.69 FLT1 KDR VEGFA
11 11.61 FLT1 SLC2A1 VEGFA
12 11.53 FLT1 KDR PROX1
13 11.47 FLT1 KDR VEGFA
14
Show member pathways
11.42 FLT1 KDR RASA1 VEGFA
15
Show member pathways
11.23 KDR VEGFA
16
Show member pathways
11.17 GLA NAGA
17 11.17 FLT1 KDR VEGFA
18 11.16 SLC2A1 VEGFA
19 11 FLT1 VEGFA
20 10.87 FLT1 KDR VEGFA
21 10.81 FLT1 KDR VEGFA
22 10.78 FUCA1 MANBA
23 10.46 FLT1 KDR SLC2A1 VEGFA
24
Show member pathways
10.34 FLT1 KDR VEGFA

GO Terms for Skin Hemangioma

Cellular components related to Skin Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.81 FLT1 FUCA1 GLA KDR NAGA PROX1
2 lysosome GO:0005764 9.26 FUCA1 GLA MANBA NAGA
3 lysosomal lumen GO:0043202 8.8 FUCA1 GLA MANBA

Biological processes related to Skin Hemangioma according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.91 FLT1 KDR RASA1 VEGFA
2 positive regulation of cell proliferation GO:0008284 9.89 FLT1 KDR PROX1 VEGFA
3 angiogenesis GO:0001525 9.8 FLT1 KDR VEGFA
4 positive regulation of cell migration GO:0030335 9.79 FLT1 KDR VEGFA
5 positive regulation of angiogenesis GO:0045766 9.74 FLT1 KDR VEGFA
6 regulation of cell shape GO:0008360 9.73 KDR RASA1 VEGFA
7 carbohydrate metabolic process GO:0005975 9.73 FUCA1 GLA MANBA NAGA
8 positive regulation of endothelial cell proliferation GO:0001938 9.69 KDR PROX1 VEGFA
9 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.67 FLT1 KDR VEGFA
10 metabolic process GO:0008152 9.67 FUCA1 GLA MANBA NAGA
11 vasculogenesis GO:0001570 9.63 KDR RASA1 VEGFA
12 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.62 KDR VEGFA
13 blood vessel morphogenesis GO:0048514 9.6 FLT1 RASA1
14 positive regulation of focal adhesion assembly GO:0051894 9.58 KDR VEGFA
15 cell migration involved in sprouting angiogenesis GO:0002042 9.58 KDR VEGFA
16 positive regulation of endothelial cell migration GO:0010595 9.58 KDR PROX1 VEGFA
17 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.55 FLT1 VEGFA
18 oligosaccharide metabolic process GO:0009311 9.54 GLA NAGA
19 positive regulation of positive chemotaxis GO:0050927 9.52 KDR VEGFA
20 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.48 KDR VEGFA
21 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.43 FLT1 KDR VEGFA
22 glycosylceramide catabolic process GO:0046477 9.32 GLA NAGA
23 glycolipid catabolic process GO:0019377 9.16 FUCA1 NAGA
24 vascular endothelial growth factor signaling pathway GO:0038084 9.13 FLT1 KDR VEGFA
25 glycoside catabolic process GO:0016139 8.8 FUCA1 GLA NAGA

Molecular functions related to Skin Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.26 GLA NAGA
2 vascular endothelial growth factor-activated receptor activity GO:0005021 9.16 FLT1 KDR
3 alpha-galactosidase activity GO:0004557 8.96 GLA NAGA
4 hydrolase activity, acting on glycosyl bonds GO:0016798 8.92 FUCA1 GLA MANBA NAGA

Sources for Skin Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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