MCID: SKN018
MIFTS: 29

Skin Hemangioma

Categories: Cancer diseases, Cardiovascular diseases, Skin diseases

Aliases & Classifications for Skin Hemangioma

MalaCards integrated aliases for Skin Hemangioma:

Name: Skin Hemangioma 12 15
Angiomatous Naevus of Skin 12
Angioma of the Skin 12
Hemangioma of Skin 70

Classifications:



External Ids:

Disease Ontology 12 DOID:471
NCIt 50 C4905
SNOMED-CT 67 254773009
UMLS 70 C0687140

Summaries for Skin Hemangioma

MalaCards based summary : Skin Hemangioma, also known as angiomatous naevus of skin, is related to hemangioma and angioma serpiginosum. An important gene associated with Skin Hemangioma is MIR424 (MicroRNA 424), and among its related pathways/superpathways are Metabolism and Sphingolipid metabolism. Affiliated tissues include skin, thyroid and spinal cord, and related phenotypes are liver/biliary system and renal/urinary system

Related Diseases for Skin Hemangioma

Diseases related to Skin Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 hemangioma 30.7 SLC2A1 RPL5 DIPK1A
2 angioma serpiginosum 11.0
3 diamond-blackfan anemia 6 10.3 RPL5 DIPK1A
4 laryngotracheitis 10.2 FUCA2 FUCA1
5 hydrocele 10.2 RPL5 DIPK1A
6 mucopolysaccharidosis, type ivb 10.1 GLA CTSA
7 angiokeratoma circumscriptum 10.1 SLC2A1 GLA
8 atrophic rhinitis 10.1 NEU1 CTSA
9 morquio syndrome 10.1 NEU1 CTSA
10 fucosidosis 10.1 NAGA FUCA2 FUCA1
11 angiokeratoma of fordyce 10.1 GLA ACE
12 pulmonary hypertension, primary, 1 10.1 RPL5 DIPK1A
13 mannosidosis, alpha b, lysosomal 10.1 MANBA FUCA2 FUCA1
14 kanzaki disease 10.1 NAGA ACE
15 hydrops fetalis, nonimmune 10.0 NEU1 CTSA
16 mucolipidosis iii alpha/beta 10.0 FUCA2 FUCA1
17 galactosialidosis 10.0 NEU1 CTSA
18 atrial heart septal defect 9.9 RPL5 DIPK1A ACE
19 thyroid carcinoma 9.9
20 scheie syndrome 9.9 GLA FUCA2 FUCA1 CTSA
21 hepatic tuberculosis 9.9 SLC2A1 ACE
22 mucopolysaccharidosis, type iva 9.9 GLA CTSA
23 hurler syndrome 9.8 NEU1 FUCA2 FUCA1 CTSA
24 glycoproteinosis 9.8 NEU1 NAGA FUCA2 CTSA
25 neural tube defects 9.8
26 down syndrome 9.8
27 meningioma, familial 9.8
28 intracranial meningioma 9.8
29 secretory meningioma 9.8
30 lymphoplasmacyte-rich meningioma 9.8
31 childhood leukemia 9.8
32 cleft lip 9.8
33 cleft lip/palate 9.8
34 nephrotic syndrome, type 14 9.8 UGCG ETFA
35 gangliosidosis 9.7 UGCG NEU1 CTSA
36 sandhoff disease 9.7 UGCG GLA ETFA
37 atrial standstill 1 9.7 PRKAG2 GLA ACE
38 mucopolysaccharidosis-plus syndrome 9.7 NEU1 GLA FUCA2 FUCA1 CTSA
39 gaucher's disease 9.6 UGCG GLA ACE
40 lysosomal storage disease 9.5 NEU1 NAGA MANBA GLA FUCA1 CTSA
41 fabry disease 9.4 UGCG PRKAG2 NAGA GLA FUCA1
42 gm2 gangliosidosis 9.3 UGCG NEU1 NAGA GLA ETFA
43 tay-sachs disease 9.3 UGCG NEU1 NAGA GLA ETFA
44 gm1 gangliosidosis 9.3 UGCG NEU1 GLA ETFA CTSA
45 sphingolipidosis 9.1 UGCG PRKAG2 NAGA GLA ETFA CTSA
46 angiokeratoma 7.8 UGCG SLC2A1 PRKAG2 NEU1 NAGA MANBA

Graphical network of the top 20 diseases related to Skin Hemangioma:



Diseases related to Skin Hemangioma

Symptoms & Phenotypes for Skin Hemangioma

MGI Mouse Phenotypes related to Skin Hemangioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.43 ACE CTSA GLA MANBA NEU1 PRKAG2
2 renal/urinary system MP:0005367 9.23 ACE CTSA FUCA1 GLA MANBA NEU1

Drugs & Therapeutics for Skin Hemangioma

Search Clinical Trials , NIH Clinical Center for Skin Hemangioma

Genetic Tests for Skin Hemangioma

Anatomical Context for Skin Hemangioma

MalaCards organs/tissues related to Skin Hemangioma:

40
Skin, Thyroid, Spinal Cord, Breast

Publications for Skin Hemangioma

Articles related to Skin Hemangioma:

(show top 50) (show all 53)
# Title Authors PMID Year
1
A case of dyschromatosis symmetrica hereditaria with an associated eyelid hemangioma. 61
33434773 2021
2
Subcutaneous hemangioma on nasal dorsum: a case report. 61
32787966 2020
3
Radiation-induced genomic instability in breast carcinomas of the Swedish hemangioma cohort. 61
30938900 2019
4
Activation of Hedgehog Signaling in Aggressive Hepatic Hemangioma in Newborns and Infants. 61
31092427 2019
5
Outcomes of surgical treatment for hemangiomas. 61
30793785 2019
6
Retrospective cohort study and biobanking of patients treated for hemangioma in childhood - telomeres as biomarker of aging and radiation exposure. 61
28649877 2017
7
The expression and function of miR-424 in infantile skin hemangioma and its mechanism. 61
28928430 2017
8
New dosimetry for childhood skin hemangioma treatments with (226)Ra needles or tubes. 61
26104976 2015
9
Breast cancer risk and possible mechanisms of radiation-induced genomic instability in the Swedish hemangioma cohort after reanalyzed dosimetry. 61
25839758 2015
10
Duplicated filum terminale in the absence of split cord malformation: a potential cause of failed detethering procedures. 61
23743821 2014
11
[Epithelioid hemangioma: a clinicopathologic analysis of 7 cases]. 61
24314244 2013
12
[Multiple hemangiomas, polyposis coli, endometrial and papillary thyroid cancer]. 61
22388923 2012
13
Congenital vascular malformations--cerebral lesions differ from extracranial lesions by their immune expression of the glucose transporter protein GLUT1. 61
22551917 2012
14
Continuous low-dose-rate radiation of radionuclide phosphorus-32 for hemangiomas. 61
22364418 2012
15
Radiotherapy as a risk factor for malignant melanoma after childhood skin hemangioma. 61
22082956 2012
16
Contribution of skin trauma to infantile skin hemangioma. 61
21220189 2011
17
Breast cancer following radiotherapy for a hemangioma during childhood. 61
20607383 2010
18
Thyroid adenomas and carcinomas following radiotherapy for a hemangioma during infancy. 61
19515442 2009
19
[Research on laser and photodynamic therapy of skin hemangioma model-comb]. 61
19137884 2008
20
Renal involvement in multicentric Castleman disease with glomeruloid hemangioma of skin and plasmacytoma. 61
16860182 2006
21
The impact of reproductive factors on breast cancer risk--the feasibility of using Swedish population-based registers to account for the effect of confounding in cohort studies. 61
15947875 2005
22
Systemic spindle-cell proliferative disease in broiler chickens. 61
15699588 2005
23
[The expression of p73 and c-fos protein in hemangioma and its significance]. 61
15844599 2005
24
Cancer mortality after radiotherapy for a skin hemangioma during childhood. 61
15236880 2004
25
[Capillary hemangioma of the spinal cord: case report]. 61
15235746 2004
26
[Clinical application of acellular allogenic dermis with autogenous epithelium in wound repair]. 61
12822360 2003
27
Hepatic hemangioendothelioma in children: analysis of thirteen cases. 61
12800377 2003
28
Radiation effects on breast cancer risk: a pooled analysis of eight cohorts. 61
12105993 2002
29
Capillary hemangioma of the spinal cord. Report of four cases. 61
10879774 2000
30
Breast cancer risk after radiotherapy in infancy: a pooled analysis of two Swedish cohorts of 17,202 infants. 61
10319736 1999
31
Intracranial tumors after exposure to ionizing radiation during infancy: a pooled analysis of two Swedish cohorts of 28,008 infants with skin hemangioma. 61
9728664 1998
32
Outcome of reproduction in women irradiated for skin hemangioma in infancy. 61
9457901 1998
33
Intracranial tumors after radium treatment for skin hemangioma during infancy--a cohort and case-control study. 61
9254735 1997
34
Mortality from leukemia after irradiation in infancy for skin hemangioma. 61
8619025 1996
35
Breast cancer after radiotherapy for skin hemangioma in infancy. 61
8606933 1996
36
Major basement membrane components in Kaposi's sarcoma, angiosarcoma and benign vascular neogenesis. 61
8594076 1995
37
Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma. 61
7545872 1995
38
Risk of solid tumors after irradiation in infancy. 61
7576738 1995
39
Thyroid cancer after radiotherapy for skin hemangioma in infancy. 61
7972685 1994
40
[CT and MRI of parasellar cavernous hemangioma in two cases]. 61
1358366 1992
41
Radium treatment for hemangioma in early childhood. Reconstruction and dosimetry of treatments, 1920-1959. 61
2206564 1990
42
Tumors after radiotherapy for skin hemangioma in childhood. A case-control study. 61
2206565 1990
43
[Rendu-Osler-Weber syndrome presented paramedian thalamic and midbrain infarcts and primary medullary hemorrhage: a case report]. 61
2692933 1989
44
Mortality in a cohort of radiation treated childhood skin hemangiomas. 61
2611031 1989
45
Cancer incidence after radiotherapy for skin hemangioma: a retrospective cohort study in Sweden. 61
3172265 1988
46
A spinal arteriovenous malformation with hereditary cutaneous hemangiomas. 61
998575 1976
47
[Treatment of skin hemangioma with 90 Sr beta-ray]. 61
988315 1976
48
[Exceptional variant of the Sturge-Weber disease: intracranial angioblastic meningioma and skin hemangioma presenting as a "sneak lesion"]. 61
1036013 1976
49
[Skin hemangioma]. 61
4655337 1972
50
[LATE DAMAGE FOLLOWING RADIUM TREATMENT OF SKIN HEMANGIOMA IN THE REGION OF THE KNEE]. 61
14234360 1964

Variations for Skin Hemangioma

Expression for Skin Hemangioma

Search GEO for disease gene expression data for Skin Hemangioma.

Pathways for Skin Hemangioma

Pathways related to Skin Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 UGCG SLC2A1 RPL5 PRKAG2 NEU1 NAGA
2
Show member pathways
11.86 UGCG NEU1 GLA CTSA
3 11.27 NEU1 NAGA MANBA GLA FUCA2 FUCA1
4
Show member pathways
10.89 NAGA GLA
5 10.51 NEU1 MANBA FUCA2 FUCA1

GO Terms for Skin Hemangioma

Cellular components related to Skin Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 SLC2A1 RPL5 NEU1 NAGA GLA FUCA2
2 azurophil granule lumen GO:0035578 9.46 GLA FUCA2 FUCA1 CTSA
3 lysosomal lumen GO:0043202 9.35 NEU1 MANBA GLA FUCA1 CTSA
4 lysosome GO:0005764 9.23 NEU1 NAGA MANBA GLA FUCA2 FUCA1

Biological processes related to Skin Hemangioma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.8 NEU1 MANBA GLA FUCA2 FUCA1 CTSA
2 carbohydrate metabolic process GO:0005975 9.63 NEU1 NAGA MANBA GLA FUCA2 FUCA1
3 glycosphingolipid metabolic process GO:0006687 9.56 UGCG NEU1 GLA CTSA
4 oligosaccharide metabolic process GO:0009311 9.49 NAGA GLA
5 protein lipidation GO:0006497 9.48 UGCG PORCN
6 oligosaccharide catabolic process GO:0009313 9.46 NEU1 MANBA
7 fucose metabolic process GO:0006004 9.43 FUCA2 FUCA1
8 metabolic process GO:0008152 9.43 NEU1 NAGA MANBA GLA FUCA2 FUCA1
9 glycosylceramide catabolic process GO:0046477 9.4 NAGA GLA
10 glycolipid catabolic process GO:0019377 9.37 NAGA FUCA1
11 glycoside catabolic process GO:0016139 8.92 NAGA GLA FUCA2 FUCA1

Molecular functions related to Skin Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.92 NEU1 NAGA MANBA GLA FUCA2 FUCA1
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.43 NAGA MANBA GLA
3 alpha-L-fucosidase activity GO:0004560 9.16 FUCA2 FUCA1
4 hydrolase activity, acting on glycosyl bonds GO:0016798 9.1 NEU1 NAGA MANBA GLA FUCA2 FUCA1
5 alpha-galactosidase activity GO:0004557 8.96 NAGA GLA

Sources for Skin Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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