MCID: SKN002
MIFTS: 28

Skin Lipoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Skin Lipoma

MalaCards integrated aliases for Skin Lipoma:

Name: Skin Lipoma 12 15
Lipoma of Skin 12 70
Cutaneous Lipomatous Neoplasm 70
Cutaneous Lipomatous Tumor 12
Cutaneous Lipoma 12
Lipoma of Face 12

Classifications:



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Disease Ontology 12 DOID:10188
ICD9CM 34 214.0
NCIt 50 C4616 C5566
SNOMED-CT 67 255187008 93159009
UMLS 70 C0153968 C0347394 C1333174

Summaries for Skin Lipoma

Disease Ontology : 12 A skin benign neoplasm that derives from fat cells.

MalaCards based summary : Skin Lipoma, also known as lipoma of skin, is related to lipomatosis, multiple and lipomatosis. An important gene associated with Skin Lipoma is MEN1 (Menin 1), and among its related pathways/superpathways are Glioma and Aryl Hydrocarbon Receptor. Affiliated tissues include skin, and related phenotypes are Decreased sensitivity to paclitaxel and cardiovascular system

Related Diseases for Skin Lipoma

Diseases related to Skin Lipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 lipomatosis, multiple 30.1 PTEN NF1 MEN1
2 lipomatosis 30.0 PTEN MEN1
3 cowden syndrome 1 29.2 TNS1 PTEN NF1
4 cowden syndrome 28.5 TNS1 RET PTEN NF1 MEN1
5 pulmonary neuroendocrine tumor 10.2 PTEN MEN1
6 multiple mucosal neuroma 10.1 RET MEN1
7 pleomorphic lipoma 10.1
8 duodenal somatostatinoma 10.1 NF1 MEN1
9 somatostatinoma 10.1 NF1 MEN1
10 hyperparathyroidism 2 with jaw tumors 10.1 RET MEN1
11 thyroid tumor 10.1 RET PTEN
12 multiple endocrine neoplasia, type iv 10.1 RET MEN1
13 mixed glioma 10.1 PTEN NF1
14 duodenum cancer 10.1 NF1 MEN1
15 subependymal glioma 10.1 PTEN NF1
16 benign ependymoma 10.1 PTEN NF1
17 familial hypocalciuric hypercalcemia 10.0 RET MEN1
18 neuroma 10.0 RET NF1
19 parathyroid gland disease 10.0 RET MEN1
20 central nervous system benign neoplasm 10.0 PTEN NF1
21 extra-adrenal pheochromocytoma 10.0 RET NF1
22 parathyroid carcinoma 10.0 RET MEN1
23 esophagus leiomyoma 10.0 RET NF1
24 parkinson disease 8, autosomal dominant 10.0 RET GFRA1
25 adrenal medulla cancer 10.0 RET NF1
26 autonomic nervous system benign neoplasm 10.0 RET NF1
27 peripheral nervous system benign neoplasm 10.0 RET NF1
28 ganglioneuroma 9.9 RET PTEN
29 islet cell tumor 9.9 RET MEN1
30 follicular adenoma 9.9 RET PTEN MEN1
31 li-fraumeni syndrome 9.9 PTEN NF1 MEN1
32 thyroid gland medullary carcinoma 9.9 RET MEN1 GFRA1
33 hemangioma 9.9 RET PTEN MEN1
34 thyroid carcinoma, familial medullary 9.9 RET MEN1 GFRA1
35 nevus, epidermal 9.9 PTEN NF1
36 lymph node disease 9.9 RET NF1
37 penile disease 9.9 TNS1 PTEN
38 multiple endocrine neoplasia, type i 9.9 RET NF1 MEN1
39 multiple endocrine neoplasia 9.9 RET NF1 MEN1
40 persistent generalized lymphadenopathy 9.9 RET NF1 MEN1
41 paraganglioma and gastric stromal sarcoma 9.9 RET NF1 MEN1
42 paraganglioma 9.9 RET NF1 MEN1
43 carney complex variant 9.8 RET NF1 MEN1
44 endocrine organ benign neoplasm 9.8 RET NF1 MEN1
45 gastrointestinal stromal tumor 9.8 PTEN NF1 MEN1
46 von hippel-lindau syndrome 9.8 RET NF1 MEN1
47 pilocytic astrocytoma 9.8 RET PTEN NF1
48 tuberous sclerosis 1 9.8 TNS1 PTEN
49 ruvalcaba syndrome 9.8
50 tumor predisposition syndrome 9.8

Graphical network of the top 20 diseases related to Skin Lipoma:



Diseases related to Skin Lipoma

Symptoms & Phenotypes for Skin Lipoma

GenomeRNAi Phenotypes related to Skin Lipoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased sensitivity to paclitaxel GR00112-A-0 8.62 NF1 PTEN

MGI Mouse Phenotypes related to Skin Lipoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.95 ARHGEF1 MAP3K8 MEN1 NF1 PTEN RET
2 cellular MP:0005384 9.91 GFRA1 MAP3K8 MEN1 NF1 PTEN RET
3 immune system MP:0005387 9.86 ARHGEF1 GFRA1 MAP3K8 MEN1 NF1 PTEN
4 digestive/alimentary MP:0005381 9.8 GFRA1 MAP3K8 MEN1 NF1 PTEN RET
5 muscle MP:0005369 9.63 ARHGEF1 GFRA1 MEN1 NF1 PTEN RET
6 neoplasm MP:0002006 9.35 MAP3K8 MEN1 NF1 PTEN RET
7 renal/urinary system MP:0005367 9.02 GFRA1 NF1 PTEN RET TNS1

Drugs & Therapeutics for Skin Lipoma

Search Clinical Trials , NIH Clinical Center for Skin Lipoma

Genetic Tests for Skin Lipoma

Anatomical Context for Skin Lipoma

MalaCards organs/tissues related to Skin Lipoma:

40
Skin

Publications for Skin Lipoma

Articles related to Skin Lipoma:

# Title Authors PMID Year
1
Adenolipoma of the skin. 61
22558893 2011
2
Cutaneous lipoma in children: 5 cases with Bannayan-Riley-Ruvalcaba syndrome. 61
16952599 2006
3
Cutaneous apocrine cystic adenolipoma. 61
15900130 2005
4
A t(2;19)(p13;p13.2) in a giant invasive cardiac lipoma from a patient with multiple lipomatosis. 61
10824997 2000
5
Spinal dysraphism. 61
10798131 1999
6
Spontaneous pathology of the gray short-tailed opossum (Monodelphis domestica). 61
9051643 1997
7
[Encephalocraniocutaneous lipomatosis]. 61
9740851 1997
8
[Cutaneous lipoma and lipomatosis]. 61
3314627 1987
9
Facial solitary sub-cutaneous lipoma. 61
3867322 1985
10
Dysraphism associated with cutaneous lipoma. 61
4950931 1971

Variations for Skin Lipoma

Expression for Skin Lipoma

Search GEO for disease gene expression data for Skin Lipoma.

Pathways for Skin Lipoma

Pathways related to Skin Lipoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.03 RET PTEN NF1
2 10.84 RET NF1
3 10.2 RET GFRA1
4 9.43 RET GFRA1

GO Terms for Skin Lipoma

Biological processes related to Skin Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.58 PTEN NF1 ARHGEF1
2 negative regulation of epithelial cell proliferation GO:0050680 9.43 PTEN MEN1
3 phosphatidylinositol 3-kinase signaling GO:0014065 9.37 PTEN NF1
4 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.32 PTEN MEN1
5 negative regulation of cell cycle G1/S phase transition GO:1902807 9.26 PTEN MEN1
6 forebrain morphogenesis GO:0048853 9.16 PTEN NF1
7 MAPK cascade GO:0000165 9.02 RET NF1 MEN1 MAP3K8 GFRA1
8 glial cell-derived neurotrophic factor receptor signaling pathway GO:0035860 8.96 RET GFRA1

Sources for Skin Lipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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