MCID: SKN020
MIFTS: 35

Skin Papilloma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Skin Papilloma

MalaCards integrated aliases for Skin Papilloma:

Name: Skin Papilloma 12 15 74
Cutaneous Papilloma 12
Papilloma of Skin 12
Papilloma Skin 56

Classifications:



External Ids:

Disease Ontology 12 DOID:3178
NCIt 51 C4614
UMLS 74 C0347390

Summaries for Skin Papilloma

MalaCards based summary : Skin Papilloma, also known as cutaneous papilloma, is related to squamous cell papilloma of skin and papilloma. An important gene associated with Skin Papilloma is SP8 (Sp8 Transcription Factor), and among its related pathways/superpathways are Influenza A and Autophagy - animal. The drugs Miconazole and Salicylic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and testes, and related phenotypes are cellular and growth/size/body region

Related Diseases for Skin Papilloma

Diseases related to Skin Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma of skin 11.1
2 papilloma 10.6
3 squamous cell papilloma 9.9
4 adenoma 9.9
5 costello syndrome 9.8
6 schimke immunoosseous dysplasia 9.8
7 squamous cell carcinoma 9.8
8 breast adenoma 9.8
9 rhabdomyosarcoma 9.8
10 lung adenoma 9.8
11 degos 'en cocarde' erythrokeratoderma 9.8

Graphical network of the top 20 diseases related to Skin Papilloma:



Diseases related to Skin Papilloma

Symptoms & Phenotypes for Skin Papilloma

MGI Mouse Phenotypes related to Skin Papilloma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 CCDC39 EIF2AK4 IRF9 MAP2K2 ODC1 SMARCAL1
2 growth/size/body region MP:0005378 9.43 CCDC39 EIF2AK4 MAP2K2 ODC1 SMARCAL1 SP8
3 skeleton MP:0005390 9.02 CCDC39 IRF9 MAP2K2 SMARCAL1 SP8

Drugs & Therapeutics for Skin Papilloma

Drugs for Skin Papilloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 164)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 22916-47-8 4189
2
Salicylic acid Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 69-72-7 338
3
Cantharidin Approved, Investigational Phase 4,Phase 2,Not Applicable 56-25-7
4
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 99011-02-6 57469
5
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-66-6 32051
6
Bleomycin Approved, Investigational Phase 4 11056-06-7 5360373
7
Fluorouracil Approved Phase 4 51-21-8 3385
8
Epicatechin Investigational Phase 4,Phase 1 490-46-0, 35323-91-2 72276
9 Salicylates Phase 4,Phase 2,Phase 3
10 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
11 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
12 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
13 Dermatologic Agents Phase 4,Phase 2,Phase 3,Not Applicable
14 Antirheumatic Agents Phase 4,Phase 2,Phase 3
15 pyruvate Phase 4,Phase 2,Phase 3
16 Analgesics Phase 4,Phase 2,Phase 3
17 Antifungal Agents Phase 4,Phase 2,Phase 3
18 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
19 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3
20 Keratolytic Agents Phase 4,Phase 2,Phase 3,Not Applicable
21 Cyclooxygenase Inhibitors Phase 4,Phase 2,Phase 3
22 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Liver Extracts Phase 4,Phase 3
25 Antibodies Phase 4,Phase 3,Phase 1
26 Immunoglobulins Phase 4,Phase 3,Phase 1
27 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Interferon Inducers Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 interferons Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Tea Phase 4,Phase 3,Phase 2,Phase 1
33 Antibodies, Monoclonal Phase 4,Phase 3,Phase 1
34 Calcineurin Inhibitors Phase 4
35 Cyclosporins Phase 4
36 Anti-Bacterial Agents Phase 4,Phase 2
37 Nutrients Phase 4,Phase 2,Phase 3,Not Applicable
38 Trace Elements Phase 4,Phase 2,Phase 3,Not Applicable
39 Micronutrients Phase 4,Phase 2,Phase 3,Not Applicable
40 Antimetabolites Phase 4,Phase 1,Phase 2
41 Antimetabolites, Antineoplastic Phase 4,Phase 1,Phase 2
42 insulin Phase 4,Phase 3
43 Insulin, Globin Zinc Phase 4,Phase 3
44 Antibiotics, Antitubercular Phase 4
45
Petrolatum Approved, Investigational Phase 2, Phase 3,Phase 3 8009-03-8
46
Ethanol Approved Phase 2, Phase 3,Phase 3,Not Applicable 64-17-5 702
47
Aminolevulinic acid Approved Phase 3 106-60-5 137
48
Furosemide Approved, Vet_approved Phase 3,Phase 2 54-31-9 3440
49
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
50
Pancrelipase Approved, Investigational Phase 3 53608-75-6

Interventional clinical trials:

(show top 50) (show all 214)
# Name Status NCT ID Phase Drugs
1 17% Salicylate Versus 17% Salicylate-Ethyl Pyruvate for Plantar Foot Warts Unknown status NCT01712295 Phase 4 17% Salicylate with ethyl pyruvate;Salicylates
2 Does the HPV Vaccine Cause the Same Response in Adolescent Kidney and Liver Transplant Patients as in Healthy Controls? Unknown status NCT01101750 Phase 4
3 Immunogenicity and Safety of Human Papilloma Virus Vaccine in Solid Organ Transplant Recipients Unknown status NCT02624349 Phase 4 Quadravalent human papillomavirus vaccine
4 Cantharone for the Treatment of Perenial Warts Completed NCT03625960 Phase 4 Cantharidin;Trichloroacetic Acid
5 Imiquimod 5% Cream in the Treatment of External Genital or Perianal Warts in HIV+ Patients Completed NCT00761371 Phase 4 Imiquimod 5% cream
6 Study of Imiquimod Cream Prior to Ablative Therapy in External Ano-Genital Warts Completed NCT00189293 Phase 4 Imiquimod
7 Pharmacokinetic Study of Topically Applied Veregen 15% Compared With Oral Intake of Green Tea Beverage Completed NCT01082302 Phase 4 Polyphenon E (Veregen) 15% ointment
8 Investigating Veregen ™ 15% Ointment Treatment For Non-facial Verrucae in Pediatric Patients: A Pilot Study Completed NCT02622568 Phase 4 Veregen only
9 Alternate Dosing Schedules Study for HPV Vaccine Completed NCT00862810 Phase 4
10 Open-label Study of Subcutaneous Secukinumab to Evaluate Efficacy and Safety in Patients With Plaque Psoriasis Who Had Inadequate Response to Cyclosporine A Completed NCT02547714 Phase 4 Secukinumab (AIN457)
11 Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts Recruiting NCT03183765 Phase 4 Measles-Mumps-Rubella Vaccine
12 Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines Recruiting NCT03180034 Phase 4
13 HPV (Human Papilloma Virus) Vaccination After Treatment of Anal Intraepithelial Neoplasia (AIN) Active, not recruiting NCT02087384 Phase 4 Placebo
14 The Efficacy of Intra-lesional Bleomycin Versus Intra-lesional Purified Protein Derivative in Treatment of Palmoplantar Warts Not yet recruiting NCT03477448 Phase 4 Bleomycin;Purified Protein Derivative
15 A RTC to Examine the Effectiveness of 400 mg of Oral Zinc Gluconate as Adjunctive Therapy for Ano-genital Warts Terminated NCT01468636 Phase 4 Oral Zinc;Placebo
16 Comparison of Five Treatments in Patients With Plantar Warts Terminated NCT01059110 Phase 4 Salicylate ointment;Imiquimod;5-Fluoro-Uracil;Cryotherapy
17 Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts Unknown status NCT02151630 Phase 2, Phase 3 Pyruvic acid;Salicylic Acid
18 Efficacy of Laser Versus Cryotherapy in the Treatment of Warts Unknown status NCT01808443 Phase 3
19 Two-dose Schedule of Quadrivalent HPV Recombinant Vaccine in 11-year-old Boys in Mexico City Unknown status NCT02382900 Phase 3
20 Phase 3 Study of Imiquimod Creams in the Treatment of External Genital Warts Completed NCT00735462 Phase 3 2.5% imiquimod cream;3.75% imiquimod cream;Placebo cream
21 Safety and Effectiveness Study of Imiquimod Creams in the Treatment of External Genital Warts Completed NCT00674739 Phase 3 Imiquimod;3.75% imiquimod cream;placebo cream
22 Oral Zinc Gluconate as Treatment for Recalcitrant Cutaneous Warts: A Randomized, Double-blind, Placebo-controlled Trial Completed NCT01783353 Phase 2, Phase 3
23 A Study to Evaluate the Safety and Efficacy of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts Completed NCT03259620 Phase 3 CLS006;CLS006 Vehicle
24 A Phase 3 Study to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts Completed NCT02971891 Phase 3 CLS006 (Furosemide) Topical Gel;Vehicle Topical Gel
25 Low Dose Cyclophosphamide Treats Genital Warts Completed NCT00999986 Phase 3 cyclophosphamide
26 Glizigen-Viudid-External Anogenital Warts in Children and Adolescents Completed NCT01111344 Phase 3
27 Cervical Intraepithelial Neoplasm (CIN)-Warts Efficacy Trial in Women (Gardasil)(V501-013)(COMPLETED) Completed NCT00092521 Phase 3
28 Efficacy and Safety Study of Polyphenon E to Treat External Genital Warts Completed NCT00449982 Phase 3 Polyphenon E Ointment 10%, Polyphenon E Ointment 15%
29 An Investigational Study of Gardasil™ (qHPV Vaccine) in Reducing the Incidence of Anogenital Warts in Young Men (V501-020) Completed NCT00090285 Phase 3
30 PDT With Metvix® 160 mg/g Cream in Organ Transplant Recipients With Non-melanoma Skin Cancer Completed NCT00472459 Phase 3
31 Study to Test the Safety of HPV Vaccine in Women (V501-011)(COMPLETED) Completed NCT00517309 Phase 3
32 A Controlled Trial to Assess the Immunogenicity of a Proposed Paediatric Dosing Schedule of Human Papillomavirus Vaccine Completed NCT00501137 Phase 3
33 Cervical Intraepithelial Neoplasm (CIN) in Women (Gardasil)(V501-015) Completed NCT00092534 Phase 3
34 Study of an Investigational Vaccine in Pre-Adolescents and Adolescents (Gardasil)(V501-016) Completed NCT00092495 Phase 3
35 Immunogenicity Bridge Between an Investigational Monovalent Vaccine and the Equivalent Component of Gardasil (V501) a Quadrivalent Vaccine (V501-012)(COMPLETED) Completed NCT00092482 Phase 3
36 A Study of V503, a 9-valent Human Papillomavirus (9vHPV) Vaccine in Females 12-26 Years of Age Who Have Previously Received GARDASIL™ (V503-006) Completed NCT01047345 Phase 3
37 Multivalent HPV (Human Papillomavirus) Vaccine Study in 16- to 26-Year Old Men and Women (V503-003) Completed NCT01651949 Phase 3
38 Safety and Immunogenicity of Human Papillomavirus (HPV) Vaccine in Solid Organ Transplant Recipients Completed NCT00677677 Phase 3
39 Protecting Young Special Risk Females From Cervical Cancer Through Human Papilloma Virus (HPV) Vaccination Completed NCT00964210 Phase 3 Licensed quadrivalent HPV vaccine, Gardasil
40 Immunogenicity of GlaxoSmithKline Biological's Human Papillomavirus (HPV) Vaccine (580299) Versus Merck's Gardasil® in Healthy Females 18-45 Years of Age Completed NCT00423046 Phase 3
41 Topical Green Tea Ointment in Treatment of Superficial Skin Cancer Completed NCT02029352 Phase 2, Phase 3 Sinecatechins 10%;Placebo
42 Immunogenicity and Tolerability of Broad Spectrum Human Papillomavirus (HPV) Vaccine in Adult and Young Adult Women (V503-004) Completed NCT03158220 Phase 3
43 Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001) Completed NCT00543543 Phase 3
44 A Study to Evaluate the Safety, Immune Response, and Efficacy of Gardasil (V501, qHPV) in Mid-Adult Women (V501-019) Completed NCT00090220 Phase 3
45 A Study of Gardasil (V501) in Preadolescents and Adolescents (V501-018) Completed NCT00092547 Phase 3
46 GARDASIL™ Study in Healthy Females Between 9 and 26 Years of Age in Sub-Saharan Africa (V501-046) Completed NCT01245764 Phase 3
47 Efficacy and Safety of Intravenous and Subcutaneous Secukinumab in Moderate to Severe Chronic Plaque-type Psoriasis Completed NCT01412944 Phase 3 secukinumab 150mg;secukinumab 10mg/kg i.v. regimen
48 Study of A-101 Topical Solution for the Treatment of Common Warts Recruiting NCT03687372 Phase 3 A-101
49 Intralesional Candidal Antigen Versus Intralesional Zinc Sulphate in Treatment of Cutaneous Warts Recruiting NCT03158168 Phase 3 Candida Antigen;Zinc Sulfate
50 Effectiveness Study of Human Papilloma Virus (HPV) Vaccines to Prevent Recurrence of Genital Warts Recruiting NCT02750202 Phase 3

Search NIH Clinical Center for Skin Papilloma

Genetic Tests for Skin Papilloma

Anatomical Context for Skin Papilloma

MalaCards organs/tissues related to Skin Papilloma:

42
Skin, Kidney, Testes, Bone, T Cells, Breast

Publications for Skin Papilloma

Articles related to Skin Papilloma:

(show top 50) (show all 53)
# Title Authors Year
1
Poly-MVA attenuates 7,12- dimethylbenz[a]anthracene initiated and croton oil promoted skin papilloma formation on mice skin. ( 28976135 )
2017
2
Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis. ( 27506937 )
2016
3
Attenuation of DMBA/croton oil induced mouse skin papilloma by Apodytes dimidiata mediated by its antioxidant and antimutagenic potential. ( 26878464 )
2016
4
Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. ( 26572230 )
2015
5
The loss of Tm7sf gene accelerates skin papilloma formation in mice. ( 25804527 )
2015
6
Photodynamic therapy using a novel photosensitizer, TONS501, is similarly effective to ALA and EC036 photodynamic therapy on DMBA-and TPA-induced mouse skin papilloma. ( 22464765 )
2012
7
Flower-deficient mice have reduced susceptibility to skin papilloma formation. ( 22362363 )
2012
8
Phellinus rimosus (Berk.) pilat attenuates 7,12-dimethylbenz[a] anthracene induced and croton oil promoted skin papilloma formation in mice. ( 22070052 )
2011
9
Modulation of Signal Proteins: A Plausible Mechanism to Explain How a Potentized Drug Secale Cor 30C Diluted beyond Avogadro's Limit Combats Skin Papilloma in Mice. ( 19617203 )
2011
10
Bilharzia of the breast masquerading as a breast skin papilloma in a pregnant woman. ( 22353277 )
2011
11
Increased skin papilloma formation in mice lacking glutathione transferase GSTP. ( 21975931 )
2011
12
Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7,12-dimethylbenz [a] anthracene-induced skin papilloma in mice: the possible role of several key signal proteins. ( 20619141 )
2010
13
The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development. ( 19587094 )
2009
14
Congenital mucus retention cyst of penis presenting as skin papilloma. ( 17320684 )
2007
15
Potential of diallyl sulfide bearing pH-sensitive liposomes in chemoprevention against DMBA-induced skin papilloma. ( 17622315 )
2007
16
Mutation of p53 in skin papilloma and tubular breast adenoma of albino mice. ( 16624193 )
2006
17
Identification of genes and gene ontology processes critical to skin papilloma development in Tg.AC transgenic mice. ( 16329151 )
2006
18
Control of intracellular movement of connexins by E-cadherin in murine skin papilloma cells. ( 11640887 )
2001
19
Prevention of carcinogen-induced mouse skin papilloma by whole fruit aqueous extract of Momordica charantia. ( 10958332 )
2000
20
Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion. ( 9537245 )
1998
21
Mathematical modeling of skin papilloma data in SENCAR mice. ( 9439737 )
1997
22
Suppression of mouse skin papilloma by canthaxanthin and beta-carotene in vivo: possibility of the regression of tumorigenesis by carotenoids without conversion to retinoic acid. ( 8875557 )
1996
23
Inhibition of 12-O-tetradecanoylphorbol-13-acetate promoted mouse skin papilloma by digalactosyl diacylglycerols from the fresh water cyanobacterium Phormidium tenue. ( 8640752 )
1996
24
Cutaneous papilloma arising from trichoepitheliomas in a guinea pig. ( 16457539 )
1995
25
Expression of protein kinase C isoforms in skin papilloma and carcinoma of mice. ( 8062222 )
1994
26
Mouse skin papilloma formation by chronic dermal application of 7,12-dimethylbenz[a]anthracene is not reduced by diet restriction. ( 8293538 )
1994
27
Effect of excess dietary retinoic acid on skin papilloma and carcinoma formation induced by a complete carcinogenesis protocol in female Sencar mice. ( 8180970 )
1994
28
Effects of dietary retinoic acid on skin papilloma and carcinoma formation in female SENCAR mice. ( 8453733 )
1993
29
Dietary retinoids are essential for skin papilloma formation induced by either the two-stage or the complete tumorigenesis model in female SENCAR mice. ( 1451104 )
1992
30
Cutaneous papilloma with viral replication in an old dog. ( 1318757 )
1992
31
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin papilloma by saponins. ( 1846234 )
1991
32
Ultrastructural morphology of hypomelanosis in equine cutaneous papilloma. ( 2123216 )
1990
33
Inhibition of 7,12-dimethylbenz[a]anthracene-initiated and 12-O-tetradecanoylphorbol-13-acetate-promoted skin papilloma formation in mice by dehydroepiandrosterone and two synthetic analogs. ( 2529051 )
1989
34
A combined carcinogen bioassay utilizing both the lung adenoma and skin papilloma protocols. ( 3780626 )
1986
35
Dehydroepiandrosterone (DHEA) and 3 beta-methylandrost-5-en-17-one: inhibitors of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin papilloma formation in mice. ( 6231135 )
1984
36
Inhibition by quercetin of the promoting effect of teleocidin on skin papilloma formation in mice initiated with 7,12-dimethylbenz[a]anthracene. ( 6428958 )
1984
37
Further studies of eel virus (Berlin) isolated from the blood of eels (Anguilla anguilla) with skin papilloma. ( 981684 )
1976
38
Congenital cutaneous papilloma in a foal. ( 5061943 )
1972
39
Suspicious influence of thymectomy on skin papilloma induction. ( 5781976 )
1969
40
"Induction" of viral antigen in established cell line (SP-8) derived from Shope virus-induced cutaneous papilloma of rabbits. ( 4302955 )
1969
41
Meningeal tumors induced in calves with the bovine cutaneous papilloma virus. ( 4310064 )
1969
42
The ultrastructure of canine cutaneous papilloma. ( 4311565 )
1969
43
Skin papilloma production by Anthralin painting after urethan initiation in mice. ( 5726261 )
1968
44
Growth and other characteristics of a cell line (SP-8) established from Shope virus-induced cutaneous papilloma of domestic rabbit. ( 4872222 )
1968
45
Electron microscopy of the bovine cutaneous papilloma. ( 5958989 )
1966
46
HISTOPATHOLOGY OF URINARY BLADDER TUMORS INDUCED BY BOVINE CUTANEOUS PAPILLOMA AGENT. ( 14254988 )
1965
47
CORRELATION OF IMMUNOFLUORESCENCE AND INFECTIVITY IN THE DEVELOPING BOVINE CUTANEOUS PAPILLOMA. ( 14188473 )
1964
48
GIANT CUTANEOUS PAPILLOMA OF THE SHOULDER. ( 14054166 )
1963
49
Antigen of bovine cutaneous papilloma detected by fluorescent antibodies. ( 13914472 )
1961
50
A urinary bladder tumor induced by a bovine cutaneous papilloma agent. ( 14428797 )
1959

Variations for Skin Papilloma

Expression for Skin Papilloma

Search GEO for disease gene expression data for Skin Papilloma.

Pathways for Skin Papilloma

Pathways related to Skin Papilloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.28 EIF2AK4 IRF9 MAP2K2
2 11.26 EIF2AK4 MAP2K2
3 10.9 IRF9 MAP2K2

GO Terms for Skin Papilloma

Sources for Skin Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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