MCID: SKN020
MIFTS: 39

Skin Papilloma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Skin Papilloma

MalaCards integrated aliases for Skin Papilloma:

Name: Skin Papilloma 12 15 71
Cutaneous Papilloma 12
Papilloma of Skin 12
Papilloma Skin 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3178
NCIt 49 C4614
SNOMED-CT 67 255184001
UMLS 71 C0347390

Summaries for Skin Papilloma

MalaCards based summary : Skin Papilloma, also known as cutaneous papilloma, is related to squamous cell papilloma and actinic keratosis. An important gene associated with Skin Papilloma is LALBA (Lactalbumin Alpha), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin, lung and breast, and related phenotypes are Reduced mammosphere formation and endocrine/exocrine gland

Related Diseases for Skin Papilloma

Diseases related to Skin Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 248)
# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma 31.8 TP53 KRT14 HRAS
2 actinic keratosis 30.3 TP53 PTGS2 MYC HRAS
3 adenoma 30.2 TP53 PTGS2 ODC1 CCND1
4 keratosis 30.2 TP53 KRT10 KRT1 HRAS
5 exanthem 30.2 MAP2K7 HRAS AKT1
6 lung adenoma 30.2 TP53 MYC HRAS AKT1
7 palmoplantar keratoderma, epidermolytic 30.0 LORICRIN KRT14 KRT10 KRT1
8 skin disease 29.7 TP53 LORICRIN KRT14 KRT10 KRT1
9 papilloma 29.7 TP53 PTGS2 PTEN ODC1 KRT14 KRT10
10 skin carcinoma 29.5 TP53 PTGS2 ODC1 MAP2K7 JUN HRAS
11 sarcoma 29.3 TP53 PTGS2 MYC JUN HRAS CCND1
12 squamous cell carcinoma 29.0 TP53 PTGS2 PTEN MYC KRT14 HRAS
13 squamous cell papilloma of skin 11.3
14 trachea carcinoma in situ 10.6 KRT14 HRAS
15 prostate squamous cell carcinoma 10.6 TP53 HRAS
16 esophageal basaloid squamous cell carcinoma 10.5 TP53 KRT14
17 myoepithelial carcinoma 10.5 TP53 KRT14 HRAS
18 eccrine papillary adenoma 10.5 KRT14 KRT10
19 spitz nevus 10.5 TP53 HRAS
20 esophageal leukoplakia 10.5 TP53 CCND1
21 adult teratoma 10.5 TP53 HRAS
22 anal carcinoma in situ 10.5 TP53 MYC
23 cystadenocarcinoma 10.5 TP53 HRAS AKT1
24 gallbladder benign neoplasm 10.5 TP53 HRAS
25 urethra transitional cell carcinoma 10.5 TP53 HBZ
26 thyroid hurthle cell adenoma 10.5 PTEN KRT14
27 pancreatic foamy gland adenocarcinoma 10.5 TP53 CCND1
28 b cell prolymphocytic leukemia 10.5 TP53 MYC
29 acneiform dermatitis 10.4 MAP2K7 HRAS
30 large cell acanthoma 10.4 TP53 KRT14 KRT10
31 frontal lobe neoplasm 10.4 TP53 MYC
32 rectum adenocarcinoma 10.4 TP53 MYC HRAS
33 vulvar melanoma 10.4 MAP2K7 HRAS
34 borst-jadassohn intraepidermal carcinoma 10.4 TP53 KRT14 KRT10
35 keratinopathic ichthyosis 10.4 KRT10 KRT1
36 esophagus verrucous carcinoma 10.4 TP53 CCND1
37 melanoma in congenital melanocytic nevus 10.4 TP53 MAP2K7 HRAS
38 liver benign neoplasm 10.4 TP53 HRAS HPGDS
39 carcinosarcoma 10.4 TP53 PTEN HRAS
40 bowenoid papulosis 10.4 PTGS2 CCND1
41 embryonal rhabdomyosarcoma 10.4 TP53 MYC HRAS
42 hyaline fibromatosis syndrome 10.4 LORICRIN KRT14 KRT10
43 vulva cancer 10.4 TP53 HRAS CCND1
44 large intestine adenocarcinoma 10.4 TP53 PTEN HRAS
45 oral submucous fibrosis 10.4 TP53 PTGS2 LORICRIN
46 female reproductive endometrioid cancer 10.4 TP53 PTEN HRAS
47 uterine body mixed cancer 10.4 TP53 PTEN HRAS
48 epithelial-myoepithelial carcinoma 10.4 TP53 KRT14 HRAS AKT1
49 wolffian duct adenocarcinoma 10.4 TP53 HRAS
50 marek disease 10.4 TP53 JUN

Graphical network of the top 20 diseases related to Skin Papilloma:



Diseases related to Skin Papilloma

Symptoms & Phenotypes for Skin Papilloma

GenomeRNAi Phenotypes related to Skin Papilloma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CCND1 HPGDS HRAS JUN LALBA MYC

MGI Mouse Phenotypes related to Skin Papilloma:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.31 AKT1 CCDC39 CCND1 HRAS JUN KRT14
2 cellular MP:0005384 10.3 AKT1 CCDC39 CCND1 HPGDS JUN KRT14
3 growth/size/body region MP:0005378 10.29 AKT1 CCDC39 CCND1 HBZ HRAS JUN
4 cardiovascular system MP:0005385 10.28 AKT1 CCDC39 CCND1 HPGDS HRAS JUN
5 mortality/aging MP:0010768 10.27 AKT1 CCDC39 CCND1 HBZ HPGDS HRAS
6 integument MP:0010771 10.22 AKT1 CCND1 HPGDS HRAS JUN KRT1
7 immune system MP:0005387 10.21 AKT1 CCDC39 CCND1 HPGDS JUN KRT1
8 hematopoietic system MP:0005397 10.2 AKT1 CCDC39 CCND1 HBZ JUN KRT1
9 digestive/alimentary MP:0005381 10.11 CCDC39 CCND1 HRAS KRT14 MYC PTEN
10 adipose tissue MP:0005375 10.09 AKT1 KRT14 MYC ODC1 PTEN PTGS2
11 neoplasm MP:0002006 10.06 AKT1 CCND1 HPGDS HRAS KRT14 MAP2K7
12 nervous system MP:0003631 10.03 AKT1 CCDC39 CCND1 HPGDS HRAS JUN
13 normal MP:0002873 9.9 AKT1 CCND1 HRAS JUN LALBA MAP2K7
14 reproductive system MP:0005389 9.7 AKT1 CCDC39 CCND1 HBZ KRT14 MAP2K7
15 respiratory system MP:0005388 9.28 AKT1 CCDC39 CCND1 HRAS JUN KRT14

Drugs & Therapeutics for Skin Papilloma

Search Clinical Trials , NIH Clinical Center for Skin Papilloma

Genetic Tests for Skin Papilloma

Anatomical Context for Skin Papilloma

MalaCards organs/tissues related to Skin Papilloma:

40
Skin, Lung, Breast, Testes, Bone, Whole Blood, Liver

Publications for Skin Papilloma

Articles related to Skin Papilloma:

(show top 50) (show all 146)
# Title Authors PMID Year
1
Curcumin Enriched VCO Protects against 7,12-Dimethyl Benz[a] Anthracene-Induced Skin Papilloma in Mice. 61
32530305 2020
2
Discovering pH triggered charge rebound surface modulated topical nanotherapy against aggressive skin papilloma. 61
31761163 2020
3
Oral Janus kinase inhibitors for maintenance of remission in ulcerative colitis. 61
31984480 2020
4
Naringenin Suppresses Chemically Induced Skin Cancer in Two-Stage Skin Carcinogenesis Mouse Model. 61
31474152 2020
5
Detection and genomic characterization of Bovine papillomavirus isolated from Chinese native cattle. 61
31269541 2019
6
Metachronous ovarian endometrioid carcinomas in a patient with a PTEN variant: case report of incidentally detected Cowden syndrome. 61
31664961 2019
7
The risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients: a systematic review and meta-analysis. 61
30501438 2019
8
FDA Approval Summary: Vemurafenib for the Treatment of Patients with Erdheim-Chester Disease with the BRAFV600 Mutation. 61
30120160 2018
9
Nevus Lipomatosis Cutaneous Superficialis: A Single-Center Case Series of 5 Patients. 61
29928203 2018
10
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer. 61
29382705 2018
11
Vemurafenib for BRAF V600-Mutant Erdheim-Chester Disease and Langerhans Cell Histiocytosis: Analysis of Data From the Histology-Independent, Phase 2, Open-label VE-BASKET Study. 61
29188284 2018
12
Poly-MVA attenuates 7,12- dimethylbenz[a]anthracene initiated and croton oil promoted skin papilloma formation on mice skin. 61
28976135 2017
13
Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation. 61
28927034 2017
14
Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis. 61
28277539 2017
15
Validation of VX2 as a Hepatocellular Carcinoma Model: Comparison of the Molecular Reaction of VX2 and HepG2 Tumor Cells to Sorafenib In Vitro. 61
28011478 2017
16
Induction of Tyrosine Phosphorylation of UV-Activated EGFR by the Beta-Human Papillomavirus Type 8 E6 Leads to Papillomatosis. 61
29176966 2017
17
Ganoderma lucidum total triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas in experimental animals. 61
28010928 2017
18
Chronic Acrylamide Exposure in Male Mice Results in Elevated DNA Damage in the Germline and Heritable Induction of CYP2E1 in the Testes. 61
27580987 2016
19
Attenuation of DMBA/croton oil induced mouse skin papilloma by Apodytes dimidiata mediated by its antioxidant and antimutagenic potential. 61
26878464 2016
20
Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis. 61
27506937 2016
21
Inhibition of Dimethylbenz(a)anthracene (DMBA) - Croton Oil-Induced Mouse Skin Tumorigenesis by Gmelina arborea with Potential Anti-Inflammatory Activity. 61
27910781 2016
22
Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. 61
26572230 2015
23
The loss of Tm7sf gene accelerates skin papilloma formation in mice. 61
25804527 2015
24
Chemopreventive potential of Apium leptophyllum (Pers.) against DMBA induced skin carcinogenesis model by modulatory influence on biochemical and antioxidant biomarkers in Swiss mice. 61
25298584 2014
25
Photodynamic therapy using a novel irradiation source, LED lamp, is similarly effective to photodynamic therapy using diode laser or metal-halide lamp on DMBA- and TPA-induced mouse skin papillomas. 61
25099158 2014
26
SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma. 61
24909994 2014
27
Anti-carcinogenic effects of non-polar components containing licochalcone A in roasted licorice root. 61
24944769 2014
28
Anticarcinogenic effect of quercetin by inhibition of insulin-like growth factor (IGF)-1 signaling in mouse skin cancer. 61
24353828 2013
29
Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid. 61
24072817 2013
30
Bos grunniens papillomavirus type 1: a novel deltapapillomavirus associated with fibropapilloma in yak. 61
23052399 2013
31
Study on extraction process of tannins from Semen Cuscutae and their anti-papilloma activity. 61
24146476 2013
32
Flower-deficient mice have reduced susceptibility to skin papilloma formation. 61
22362363 2012
33
[Application of narrow hypodermal pedicled retroauricular flap in repairing preauricular soft tissue defect]. 61
22792772 2012
34
Photodynamic therapy using a novel photosensitizer, TONS501, is similarly effective to ALA and EC036 photodynamic therapy on DMBA-and TPA-induced mouse skin papilloma. 61
22464765 2012
35
Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles. 61
22275821 2012
36
Increased skin papilloma formation in mice lacking glutathione transferase GSTP. 61
21975931 2011
37
Bilharzia of the breast masquerading as a breast skin papilloma in a pregnant woman. 61
22353277 2011
38
Chemopreventive effects of wild carrot oil against 7,12-dimethyl benz(a)anthracene-induced squamous cell carcinoma in mice. 61
21777042 2011
39
PTEN positively regulates UVB-induced DNA damage repair. 61
21771908 2011
40
Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis. 61
21119595 2011
41
Phellinus rimosus (Berk.) pilat attenuates 7,12-dimethylbenz[a] anthracene induced and croton oil promoted skin papilloma formation in mice. 61
22070052 2011
42
Modulation of Signal Proteins: A Plausible Mechanism to Explain How a Potentized Drug Secale Cor 30C Diluted beyond Avogadro's Limit Combats Skin Papilloma in Mice. 61
19617203 2011
43
Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7,12-dimethylbenz [a] anthracene-induced skin papilloma in mice: the possible role of several key signal proteins. 61
20619141 2010
44
Hexafluoroisopropanol-induced helix-sheet transition of stem bromelain: correlation to function. 61
20156582 2010
45
Elevated phosphate activates N-ras and promotes cell transformation and skin tumorigenesis. 61
20145188 2010
46
The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development. 61
19587094 2009
47
Critical role for constitutive type I interferon signaling in the prevention of cellular transformation. 61
19076978 2009
48
Evaluation of anticarcinogenic and antimutagenic potential of Bauhinia variegata extract in Swiss albino mice. 61
20104989 2009
49
Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase. 61
18952840 2008
50
Carcinogenic comparative study on rasH2 mice produced by two breeding facilities. 61
18827450 2008

Variations for Skin Papilloma

Expression for Skin Papilloma

Search GEO for disease gene expression data for Skin Papilloma.

Pathways for Skin Papilloma

Pathways related to Skin Papilloma according to GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.13 TP53 PVR PTGS2 PTEN MYC MAP2K7
2
Show member pathways
13.91 TP53 PTGS2 PTEN MYC MAP2K7 JUN
3
Show member pathways
13.31 TP53 PTEN MYC MAP2K7 JUN HRAS
4
Show member pathways
13.15 TP53 MYC MAP2K7 JUN HRAS CCND1
5
Show member pathways
13.08 TP53 PTGS2 PTEN MYC HRAS CCND1
6
Show member pathways
13.02 TP53 PTGS2 MAP2K7 JUN HRAS AKT1
7
Show member pathways
12.99 PTGS2 PTEN MAP2K7 JUN HRAS CCND1
8
Show member pathways
12.99 TP53 PTGS2 MYC MAP2K7 JUN HRAS
9
Show member pathways
12.96 TP53 PTEN MYC JUN HRAS CCND1
10
Show member pathways
12.92 TP53 MYC MAP2K7 JUN CCND1 AKT1
11 12.89 TP53 PTGS2 PTEN MYC JUN HRAS
12
Show member pathways
12.88 PTEN MYC JUN HRAS CCND1 AKT1
13 12.86 TP53 MYC MAP2K7 JUN HRAS AKT1
14
Show member pathways
12.84 TP53 PTEN MYC JUN HRAS CCND1
15
Show member pathways
12.8 TP53 MYC JUN HRAS AKT1
16
Show member pathways
12.78 TP53 PTGS2 PTEN MAP2K7 JUN HRAS
17
Show member pathways
12.77 MAP2K7 KRT14 KRT10 JUN HRAS AKT1
18
Show member pathways
12.76 TP53 MAP2K7 JUN HRAS AKT1
19
Show member pathways
12.74 MAP2K7 JUN HRAS CCND1 AKT1
20
Show member pathways
12.74 TP53 PTEN MAP2K7 JUN HRAS CCND1
21
Show member pathways
12.7 PTEN MAP2K7 JUN HRAS AKT1
22
Show member pathways
12.68 PTGS2 PTEN MAP2K7 JUN HRAS AKT1
23
Show member pathways
12.63 PTEN MAP2K7 JUN HRAS AKT1
24
Show member pathways
12.61 TP53 PTEN PDCD4 HRAS AKT1
25 12.59 TP53 PTGS2 PTEN PDCD4 MYC HRAS
26
Show member pathways
12.58 PTEN MYC JUN HRAS CCND1 AKT1
27
Show member pathways
12.55 PTEN MAP2K7 JUN HRAS AKT1
28
Show member pathways
12.53 PTGS2 MAP2K7 JUN HRAS AKT1
29
Show member pathways
12.52 TP53 JUN HRAS AKT1
30
Show member pathways
12.52 TP53 PTEN MYC MAP2K7 JUN HRAS
31
Show member pathways
12.51 PTEN MYC JUN HRAS AKT1
32
Show member pathways
12.49 MAP2K7 JUN HRAS AKT1
33
Show member pathways
12.48 PTGS2 JUN HRAS AKT1
34
Show member pathways
12.48 TP53 PTEN MYC MAP2K7 JUN HRAS
35
Show member pathways
12.47 PTEN MAP2K7 JUN AKT1
36
Show member pathways
12.47 TP53 PTEN MYC HRAS CCND1 AKT1
37
Show member pathways
12.46 TP53 PTEN MYC CCND1
38
Show member pathways
12.42 TP53 PTGS2 JUN HRAS AKT1
39
Show member pathways
12.42 TP53 PTEN HRAS CCND1 AKT1
40
Show member pathways
12.42 MYC MAP2K7 JUN HRAS AKT1
41 12.42 TP53 PTGS2 MYC MAP2K7 JUN CCND1
42
Show member pathways
12.41 MYC HRAS CCND1 AKT1
43
Show member pathways
12.41 PTGS2 HRAS CCND1 AKT1
44 12.41 MYC MAP2K7 JUN HRAS AKT1
45
Show member pathways
12.4 TP53 MAP2K7 JUN HRAS AKT1
46 12.39 TP53 JUN HRAS CCND1
47
Show member pathways
12.39 MYC MAP2K7 JUN AKT1
48 12.37 TP53 PDCD4 MYC HRAS CCND1 AKT1
49
Show member pathways
12.35 TP53 PTEN CCND1 AKT1
50
Show member pathways
12.32 TP53 MYC JUN CCND1

GO Terms for Skin Papilloma

Cellular components related to Skin Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.86 TP53 PVR PTGS2 PTEN PDCD4 ODC1
2 cytosol GO:0005829 9.5 TP53 PTEN PDCD4 ODC1 MAP2K7 LORICRIN
3 cornified envelope GO:0001533 9.33 LORICRIN KRT10 KRT1

Biological processes related to Skin Papilloma according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.04 TP53 PTEN MYC HRAS AKT1
2 negative regulation of cell proliferation GO:0008285 10.02 TP53 PTGS2 PTEN JUN HRAS
3 positive regulation of apoptotic process GO:0043065 9.98 TP53 PTGS2 PTEN JUN AKT1
4 apoptotic process GO:0006915 9.98 TP53 PTEN PDCD4 MAP2K7 LALBA HRAS
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.93 PTEN MAP2K7 JUN HRAS
6 cytokine-mediated signaling pathway GO:0019221 9.93 TP53 PTGS2 MYC CCND1 AKT1
7 keratinization GO:0031424 9.91 LORICRIN KRT14 KRT10 KRT1
8 regulation of cell cycle GO:0051726 9.88 TP53 PTEN JUN CCND1
9 negative regulation of apoptotic process GO:0043066 9.87 TP53 PTGS2 PTEN PDCD4 MYC JUN
10 response to oxidative stress GO:0006979 9.86 TP53 PTGS2 KRT1 AKT1
11 liver development GO:0001889 9.83 JUN HRAS CCND1
12 response to organic cyclic compound GO:0014070 9.83 PTGS2 PTEN JUN CCND1
13 Ras protein signal transduction GO:0007265 9.81 TP53 JUN HRAS
14 cornification GO:0070268 9.81 LORICRIN KRT14 KRT10 KRT1
15 response to estradiol GO:0032355 9.8 PTGS2 PTEN MYC CCND1
16 aging GO:0007568 9.8 PTGS2 PTEN KRT14 JUN AKT1
17 positive regulation of epithelial cell proliferation GO:0050679 9.79 MYC HRAS CCND1
18 cellular response to UV GO:0034644 9.77 TP53 PTGS2 MYC
19 response to drug GO:0042493 9.73 TP53 PTGS2 PTEN MYC JUN CCND1
20 positive regulation of smooth muscle cell proliferation GO:0048661 9.67 PTGS2 MYC JUN AKT1
21 positive regulation of mitochondrial membrane potential GO:0010918 9.65 MYC AKT1
22 ovulation GO:0030728 9.65 PTGS2 MYC
23 cyclooxygenase pathway GO:0019371 9.65 PTGS2 HPGDS
24 cell aging GO:0007569 9.65 TP53 PDCD4 HRAS
25 negative regulation of cell size GO:0045792 9.64 PTEN AKT1
26 peptide cross-linking GO:0018149 9.63 LORICRIN KRT10 KRT1
27 mitotic G1 DNA damage checkpoint GO:0031571 9.62 TP53 CCND1
28 re-entry into mitotic cell cycle GO:0000320 9.6 MYC CCND1
29 cellular response to decreased oxygen levels GO:0036294 9.57 PTEN AKT1
30 response to UV-A GO:0070141 9.55 CCND1 AKT1
31 cellular response to hypoxia GO:0071456 9.55 TP53 PTGS2 PTEN MYC AKT1
32 response to organic substance GO:0010033 9.35 PTGS2 PTEN JUN CCND1 AKT1
33 positive regulation of cell proliferation GO:0008284 9.23 PTGS2 PTEN ODC1 MYC JUN HRAS

Molecular functions related to Skin Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.11 TP53 PVR PTGS2 PTEN PDCD4 ODC1
2 protein kinase binding GO:0019901 9.65 TP53 PTEN MAP2K7 CCND1 AKT1
3 enzyme binding GO:0019899 9.17 TP53 PTGS2 PTEN MAP2K7 JUN CCND1
4 structural constituent of epidermis GO:0030280 9.13 LORICRIN KRT10 KRT1

Sources for Skin Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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