MCID: SKN020
MIFTS: 31

Skin Papilloma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Skin Papilloma

MalaCards integrated aliases for Skin Papilloma:

Name: Skin Papilloma 12 15 72
Cutaneous Papilloma 12
Papilloma of Skin 12
Papilloma Skin 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3178
NCIt 50 C4614
UMLS 72 C0347390

Summaries for Skin Papilloma

MalaCards based summary : Skin Papilloma, also known as cutaneous papilloma, is related to papilloma and palmoplantar keratoderma, epidermolytic. An important gene associated with Skin Papilloma is HRAS (HRas Proto-Oncogene, GTPase), and among its related pathways/superpathways are Toll Comparative Pathway and Proteoglycans in cancer. Affiliated tissues include skin, lung and testes, and related phenotypes are growth/size/body region and craniofacial

Related Diseases for Skin Papilloma

Diseases related to Skin Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 papilloma 31.1 TP53 ODC1 KRT14
2 palmoplantar keratoderma, epidermolytic 29.6 LOR KRT14
3 squamous cell papilloma of skin 11.3
4 squamous cell papilloma 10.7
5 spitz nevus 10.5 TP53 HRAS
6 nasal cavity adenocarcinoma 10.4 TP53 HRAS
7 prostate squamous cell carcinoma 10.4 TP53 HRAS
8 meningeal melanomatosis 10.4 TP53 HRAS
9 biliary papillomatosis 10.4 TP53 HRAS
10 liver angiosarcoma 10.4 TP53 HRAS
11 mixed cell type cancer 10.4 TP53 HRAS
12 ampulla of vater cancer 10.3 TP53 HRAS
13 fibroepithelial basal cell carcinoma 10.3 TP53 KRT14
14 bile duct adenocarcinoma 10.3 TP53 HRAS
15 breast squamous cell carcinoma 10.3 TP53 KRT14
16 spiradenoma 10.3 TP53 KRT14
17 ovary adenocarcinoma 10.3 TP53 HRAS
18 thoracic benign neoplasm 10.3 TP53 KRT14
19 gastrointestinal system benign neoplasm 10.2 TP53 HRAS
20 breast benign neoplasm 10.2 TP53 KRT14
21 esophageal basaloid squamous cell carcinoma 10.2 TP53 KRT14
22 basaloid squamous cell carcinoma 10.2 TP53 KRT14
23 skin carcinoma 10.2
24 tonsil cancer 10.2 TP53 KRT14
25 intestinal benign neoplasm 10.2 TP53 ODC1 HRAS
26 skin squamous cell carcinoma 10.2 TP53 HRAS
27 colorectal adenoma 10.2 TP53 ODC1 HRAS
28 pinguecula 10.2 TP53 KRT14
29 adermatoglyphia 10.2 LOR KRT14
30 pre-malignant neoplasm 10.2 TP53 KRT14
31 skin benign neoplasm 10.1 ODC1 KRT14 HRAS
32 oropharynx cancer 10.1 TP53 KRT14
33 lung benign neoplasm 10.1 TP53 HRAS
34 epithelial-myoepithelial carcinoma 10.0 TP53 KRT14 HRAS
35 lipid-rich carcinoma 10.0 LALBA KRT14
36 ovary epithelial cancer 10.0 TP53 HRAS
37 in situ carcinoma 10.0 TP53 KRT14
38 differentiated thyroid carcinoma 10.0 TP53 HRAS CRABP1
39 adenoid cystic carcinoma 10.0 TP53 KRT14 HRAS
40 sarcoma 9.9
41 keratosis 9.9
42 spindle cell sarcoma 9.9
43 adenoma 9.9
44 actinic keratosis 9.9
45 costello syndrome 9.8
46 schimke immunoosseous dysplasia 9.8
47 lupus erythematosus 9.8
48 immuno-osseous dysplasia 9.8
49 malignant ovarian surface epithelial-stromal neoplasm 9.8 TP53 HRAS
50 hypercarotenemia and vitamin a deficiency, autosomal dominant 9.8

Graphical network of the top 20 diseases related to Skin Papilloma:



Diseases related to Skin Papilloma

Symptoms & Phenotypes for Skin Papilloma

MGI Mouse Phenotypes related to Skin Papilloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.76 CCDC39 HBZ HRAS ITPR1 KRT14 ODC1
2 craniofacial MP:0005382 9.65 CCDC39 HRAS KRT14 SP8 TP53
3 mortality/aging MP:0010768 9.61 CCDC39 CRABP1 HBZ HRAS ITPR1 KRT14
4 respiratory system MP:0005388 9.02 CCDC39 HRAS KRT14 SP8 TP53

Drugs & Therapeutics for Skin Papilloma

Search Clinical Trials , NIH Clinical Center for Skin Papilloma

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Cantharidin

Genetic Tests for Skin Papilloma

Anatomical Context for Skin Papilloma

MalaCards organs/tissues related to Skin Papilloma:

41
Skin, Lung, Testes, Breast, Liver, Bone, Whole Blood

Publications for Skin Papilloma

Articles related to Skin Papilloma:

(show top 50) (show all 141)
# Title Authors PMID Year
1
Detection and genomic characterization of Bovine papillomavirus isolated from Chinese native cattle. 38
31269541 2019
2
The risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients: a systematic review and meta-analysis. 38
30501438 2019
3
FDA Approval Summary: Vemurafenib for the Treatment of Patients with Erdheim-Chester Disease with the BRAFV600 Mutation. 38
30120160 2018
4
Nevus Lipomatosis Cutaneous Superficialis: A Single-Center Case Series of 5 Patients. 38
29928203 2018
5
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer. 38
29382705 2018
6
Vemurafenib for BRAF V600-Mutant Erdheim-Chester Disease and Langerhans Cell Histiocytosis: Analysis of Data From the Histology-Independent, Phase 2, Open-label VE-BASKET Study. 38
29188284 2018
7
Poly-MVA attenuates 7,12- dimethylbenz[a]anthracene initiated and croton oil promoted skin papilloma formation on mice skin. 38
28976135 2017
8
Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation. 38
28927034 2017
9
Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis. 38
28277539 2017
10
Validation of VX2 as a Hepatocellular Carcinoma Model: Comparison of the Molecular Reaction of VX2 and HepG2 Tumor Cells to Sorafenib In Vitro. 38
28011478 2017
11
Ganoderma lucidum total triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas in experimental animals. 38
28010928 2017
12
Induction of Tyrosine Phosphorylation of UV-Activated EGFR by the Beta-Human Papillomavirus Type 8 E6 Leads to Papillomatosis. 38
29176966 2017
13
Chronic Acrylamide Exposure in Male Mice Results in Elevated DNA Damage in the Germline and Heritable Induction of CYP2E1 in the Testes. 38
27580987 2016
14
Attenuation of DMBA/croton oil induced mouse skin papilloma by Apodytes dimidiata mediated by its antioxidant and antimutagenic potential. 38
26878464 2016
15
Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis. 38
27506937 2016
16
Inhibition of Dimethylbenz(a)anthracene (DMBA) - Croton Oil-Induced Mouse Skin Tumorigenesis by Gmelina arborea with Potential Anti-Inflammatory Activity. 38
27910781 2016
17
Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. 38
26572230 2015
18
The loss of Tm7sf gene accelerates skin papilloma formation in mice. 38
25804527 2015
19
Chemopreventive potential of Apium leptophyllum (Pers.) against DMBA induced skin carcinogenesis model by modulatory influence on biochemical and antioxidant biomarkers in Swiss mice. 38
25298584 2014
20
Photodynamic therapy using a novel irradiation source, LED lamp, is similarly effective to photodynamic therapy using diode laser or metal-halide lamp on DMBA- and TPA-induced mouse skin papillomas. 38
25099158 2014
21
SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma. 38
24909994 2014
22
Anti-carcinogenic effects of non-polar components containing licochalcone A in roasted licorice root. 38
24944769 2014
23
Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid. 38
24072817 2013
24
Anticarcinogenic effect of quercetin by inhibition of insulin-like growth factor (IGF)-1 signaling in mouse skin cancer. 38
24353828 2013
25
Bos grunniens papillomavirus type 1: a novel deltapapillomavirus associated with fibropapilloma in yak. 38
23052399 2013
26
Study on extraction process of tannins from Semen Cuscutae and their anti-papilloma activity. 38
24146476 2013
27
Flower-deficient mice have reduced susceptibility to skin papilloma formation. 38
22362363 2012
28
[Application of narrow hypodermal pedicled retroauricular flap in repairing preauricular soft tissue defect]. 38
22792772 2012
29
Photodynamic therapy using a novel photosensitizer, TONS501, is similarly effective to ALA and EC036 photodynamic therapy on DMBA-and TPA-induced mouse skin papilloma. 38
22464765 2012
30
Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles. 38
22275821 2012
31
Increased skin papilloma formation in mice lacking glutathione transferase GSTP. 38
21975931 2011
32
Bilharzia of the breast masquerading as a breast skin papilloma in a pregnant woman. 38
22353277 2011
33
Chemopreventive effects of wild carrot oil against 7,12-dimethyl benz(a)anthracene-induced squamous cell carcinoma in mice. 38
21777042 2011
34
PTEN positively regulates UVB-induced DNA damage repair. 38
21771908 2011
35
Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis. 38
21119595 2011
36
Modulation of Signal Proteins: A Plausible Mechanism to Explain How a Potentized Drug Secale Cor 30C Diluted beyond Avogadro's Limit Combats Skin Papilloma in Mice. 38
19617203 2011
37
Phellinus rimosus (Berk.) pilat attenuates 7,12-dimethylbenz[a] anthracene induced and croton oil promoted skin papilloma formation in mice. 38
22070052 2011
38
Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7,12-dimethylbenz [a] anthracene-induced skin papilloma in mice: the possible role of several key signal proteins. 38
20619141 2010
39
Hexafluoroisopropanol-induced helix-sheet transition of stem bromelain: correlation to function. 38
20156582 2010
40
Elevated phosphate activates N-ras and promotes cell transformation and skin tumorigenesis. 38
20145188 2010
41
The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development. 38
19587094 2009
42
Critical role for constitutive type I interferon signaling in the prevention of cellular transformation. 38
19076978 2009
43
Evaluation of anticarcinogenic and antimutagenic potential of Bauhinia variegata extract in Swiss albino mice. 38
20104989 2009
44
Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase. 38
18952840 2008
45
Carcinogenic comparative study on rasH2 mice produced by two breeding facilities. 38
18827450 2008
46
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. 38
18178624 2008
47
Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis. 38
17942901 2007
48
Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice. 38
17965551 2007
49
Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice. 38
17321042 2007
50
Potential of diallyl sulfide bearing pH-sensitive liposomes in chemoprevention against DMBA-induced skin papilloma. 38
17622315 2007

Variations for Skin Papilloma

Expression for Skin Papilloma

Search GEO for disease gene expression data for Skin Papilloma.

Pathways for Skin Papilloma

GO Terms for Skin Papilloma

Biological processes related to Skin Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.56 TP53 LALBA ITPR1 HRAS
2 intrinsic apoptotic signaling pathway GO:0097193 9.16 TP53 HRAS
3 cellular response to gamma radiation GO:0071480 8.96 TP53 HRAS
4 cell aging GO:0007569 8.62 TP53 HRAS

Sources for Skin Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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