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MCID: SKN006
MIFTS: 42

Skin Sarcoidosis

Categories: Immune diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Skin Sarcoidosis

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MalaCards integrated aliases for Skin Sarcoidosis:

Name: Skin Sarcoidosis 12 15 17
Cutaneous Sarcoidosis 12 70
Cutaneous Sarcoid 12

Classifications:

MalaCards categories:
Anatomical: Immune diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:13402
NCIt 50 C34996
SNOMED-CT 67 55941000
ICD10 32 D86.3
UMLS 70 C0036203
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Summaries for Skin Sarcoidosis

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MalaCards based summary : Skin Sarcoidosis, also known as cutaneous sarcoidosis, is related to urticaria and necrobiosis lipoidica. An important gene associated with Skin Sarcoidosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Thalidomide and Apremilast have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and t cells, and related phenotypes are endocrine/exocrine gland and hematopoietic system

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Related Diseases for Skin Sarcoidosis

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Diseases related to Skin Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 632)
# Related Disease Score Top Affiliating Genes
1 urticaria 30.2 TNF CD4 ACE
2 necrobiosis lipoidica 30.1 TNF CD1B
3 iridocyclitis 30.0 TNF CD4 ACE
4 alopecia 29.9 TNF IL2 IFNG CTLA4
5 lepromatous leprosy 29.8 TNF IL2 IFNG
6 seborrheic dermatitis 29.8 CD4 CD1C CD1B
7 uveitis 29.8 TNF IL2 IFNG CTLA4
8 pulmonary sarcoidosis 29.8 TNF IL2 IFNG ACE
9 cutaneous leishmaniasis 29.8 TNF IL2 IFNG
10 leishmaniasis 29.8 TNF IL2 IFNG
11 cardiac sarcoidosis 29.7 TNF IFNG ACE
12 purpura 29.7 TNF IFNG ACE
13 erythema nodosum 29.7 TNF IFNG CTLA4
14 histoplasmosis 29.7 TNF IFNG CD4
15 tuberculoid leprosy 29.7 TNF IL2 IFNG CD4 CD1B
16 cutaneous t cell lymphoma 29.6 IL2 IFNG IFNA1
17 crohn's colitis 29.6 TNF IL2 IFNG
18 erythema multiforme 29.6 TNF IL2 IFNG
19 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.6 IFNG CTLA4
20 lichen planus 29.6 TNF IL2 IFNG
21 lymphopenia 29.6 IL2 IFNG CTLA4
22 pulmonary tuberculosis 29.6 TNF IL2 IFNG
23 neurosarcoidosis 29.5 TNF CD8A CD4 ACE
24 granuloma annulare 29.5 TNF CD4 CD1C CD1B
25 keratitis, hereditary 29.5 TNF CD8A CD4
26 autoimmune disease 29.4 TNF IL2 IFNG IFNA1 CTLA4
27 mycosis fungoides 29.4 IL2 IFNG IFNA1 CTLA4
28 thymoma 29.4 IL2 CTLA4 CD8A
29 syphilis 29.4 TNF IFNG CD8A CD4 ACE
30 cd40 ligand deficiency 29.3 IFNG CD8A CD4
31 juvenile rheumatoid arthritis 29.3 TNF IL2 IFNG CTLA4
32 psoriatic arthritis 29.3 TNF IL2 IFNG CTLA4
33 sarcoidosis 1 29.3 TNF IL2 IFNG CD8A CD4 ACE
34 cutaneous lupus erythematosus 29.3 TNF IFNG IFNA1 CTLA4
35 folliculitis 29.2 IFNG CD4 CD1C CD1B
36 vascular disease 29.1 TNF IL2 IFNG CD4 ACE
37 type 1 diabetes mellitus 29.1 TNF IL2 IFNG CTLA4 ACE
38 crohn's disease 29.1 TNF IL2 IFNG CTLA4 CD4
39 colitis 29.0 TNF IL2 IFNG CTLA4 CD4
40 thyroiditis 29.0 TNF IL2 IFNG IFNA1 CTLA4
41 common variable immunodeficiency 29.0 TNF IL2 IFNG CTLA4 CD83
42 eye disease 28.9 TNF IL2 IFNG CD8A CD4
43 vitiligo-associated multiple autoimmune disease susceptibility 1 28.9 TNF IL2 CTLA4 CD8A CD4
44 autoimmune lymphoproliferative syndrome 28.9 TNF IL2 CTLA4 CD8A CD4
45 myeloma, multiple 28.9 TNF IL2 CTLA4 CD8A CD4
46 diabetes mellitus 28.8 TNF IL2 IFNG CTLA4 CD4 ACE
47 psoriasis 28.8 TNF IL2 IFNG CTLA4 CD4 ACE
48 systemic scleroderma 28.8 TNF IFNG CD8A CD4 ACE
49 asthma 28.7 TNF IL2 IFNG CTLA4 CD4
50 aplastic anemia 28.7 TNF IL2 IFNG IFNA1 CTLA4 CD4

Graphical network of the top 20 diseases related to Skin Sarcoidosis:



Diseases related to Skin Sarcoidosis
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Symptoms & Phenotypes for Skin Sarcoidosis

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MGI Mouse Phenotypes related to Skin Sarcoidosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 ACE CD4 CD8A CTLA4 IFNG IL2
2 hematopoietic system MP:0005397 9.56 ACE CD4 CD83 CD8A CTLA4 IFNG
3 immune system MP:0005387 9.23 ACE CD4 CD83 CD8A CTLA4 IFNG
Sources

Drugs & Therapeutics for Skin Sarcoidosis

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Drugs for Skin Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thalidomide Approved, Investigational, Withdrawn Phase 3 50-35-1 5426
2
Apremilast Approved, Investigational Phase 2, Phase 3 608141-41-9 11561674
3 Hormone Antagonists Phase 2, Phase 3
4 Hormones Phase 2, Phase 3
5 Adrenocorticotropic Hormone Phase 2, Phase 3
6 Melanocyte-Stimulating Hormones Phase 2, Phase 3
7 beta-Endorphin Phase 2, Phase 3
8 Immunosuppressive Agents Phase 3
9 Angiogenesis Inhibitors Phase 3
10 Anti-Infective Agents Phase 3
11 Immunologic Factors Phase 3
12 Anti-Bacterial Agents Phase 3
13
Tofacitinib Approved, Investigational Phase 1 477600-75-2
14 Protein Kinase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ACTHAR Gel for Cutaneous Sarcoidosis: An Open Label Trial Unknown status NCT02348905 Phase 2, Phase 3 ACTHAR Gel 40 units twice weekly;ACTHAR Gel 80 units twice weekly.
2 Randomized Controlled Trial of Thalidomide vs Placebo in Skin Sarcoidosis Completed NCT00305552 Phase 3 THALIDOMIDE
3 The Efficacy and Safety of CC-10004 in Chronic Cutaneous Sarcoidosis Completed NCT00794274 Phase 2, Phase 3 CC-100004
4 A Double-Blind, Randomized, Placebo-Controlled Study of Adalimumab in the Treatment of Cutaneous Sarcoidosis Completed NCT00274352 Phase 2 adalimumab
5 A Phase II, Multi-Center, Open Label Study to Determine the Efficacy of Adalimumab in the Treatment of Cutaneous Sarcoidosis (HUM 04-36) Withdrawn NCT00690911 Phase 2 adalimumab
6 A Phase 2A, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Sequential, Dose-Ascending Study Of CC-220 In Subjects With Chronic Cutaneous Sarcoidosis Withdrawn NCT02192489 Phase 2 CC-220 0.3 mg Daily;CC-220 0.6mg Daily;Placebo
7 A Phase II, Multi-Center, Open Label Study to Determine the Efficacy of Adalimumab in the Treatment of Cutaneous Sarcoidosis Withdrawn NCT00731757 Phase 2 Humira
8 Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare Active, not recruiting NCT03910543 Phase 1 Tofacitinib 5 mg twice daily

Search NIH Clinical Center for Skin Sarcoidosis

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Genetic Tests for Skin Sarcoidosis

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Anatomical Context for Skin Sarcoidosis

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MalaCards organs/tissues related to Skin Sarcoidosis:

40
Skin, Thyroid, T Cells, Bone Marrow, Eye, Thymus, Colon
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Publications for Skin Sarcoidosis

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Articles related to Skin Sarcoidosis:

(show top 50) (show all 655)
# Title Authors PMID Year
1
Ulcerative cutaneous sarcoidosis successfully treated with infliximab. 61
33728543 2021
2
Combined pulsed-dye laser and medical therapy for treatment of cutaneous sarcoidosis lesions: a case report. 61
33719667 2021
3
Treatment of cutaneous sarcoidosis with tofacitinib 2% ointment and extra virgin olive oil. 61
33598514 2021
4
Case Report and Review of 7 Similar Cases in the Literature: Cutaneous Sarcoidosis as Side Effect of Pembrolizumab Plus Chemotherapy in Stage IV Squamous Cell Carcinoma of Lung. 61
33298795 2021
5
Clinical phenotypes and therapeutic responses in cutaneous-predominant sarcoidosis: 6 years' experience in a tertiary referral service. 61
33608920 2021
6
[Low-dose, long-term fumaric acid esters in recalcitrant cutaneous sarcoidosis : Report of two cases]. 61
33598739 2021
7
A case report of cutaneous leishmaniasis: a misleading clinical presentation. 61
32876896 2021
8
Ultrasonographic Patterns of Cutaneous Sarcoidosis. 61
33459396 2021
9
[Diffused ulcerated cutaneous sarcoidosis occurring on top of scars]. 61
33092890 2020
10
Apremilast in dermatology: A review of literature. 61
32876993 2020
11
Acute generalized exanthematous pustulosis and Stevens-Johnson syndrome overlap due to hydroxychloroquine: a case report. 61
33138853 2020
12
Practice gaps in the evaluation of systemic involvement in patients with cutaneous sarcoidosis presenting to dermatology: a retrospective review of 48 patients. 61
33096130 2020
13
Cutaneous Sarcoidosis. 61
32593176 2020
14
Cutaneous Sarcoidosis: A Case of the Great Imitator. 61
33083042 2020
15
[Periorbital erythematous plaques and papules in an HIV-positive patient : A case report]. 61
32356073 2020
16
Presentation of squamous cell carcinoma in pre-existing cutaneous sarcoidosis. 61
32843386 2020
17
Sarcoidosis with small syringotropic granulomas presenting clinically as a pigmented purpuric dermatosis: Inconspicuous clinical and histopathological clues to systemic illness. 61
32208528 2020
18
An unusual presentation of cutaneous sarcoidosis. 61
32385925 2020
19
Tiger Man Sign-F-18 FDG PET CT Scan Pattern in Muscular and Cutaneous Sarcoidosis: A Case Report and Literature Survey. 61
33082681 2020
20
Clinico-pathological spectrum of cutaneous sarcoidosis: an experience from a government institute in North India. 61
32832888 2020
21
CD163-positive macrophage infiltration predicts systemic involvement in sarcoidosis. 61
32125018 2020
22
Association of Propionibacterium acnes with the efficacy of minocycline therapy for cutaneous sarcoidosis. 61
32333400 2020
23
A prospective comparison of cutaneous sarcoidosis disease response to immunomodulatory and immunosuppressive therapies. 61
32151628 2020
24
[Uveitis and tattoos]. 61
32296242 2020
25
Colon Sarcoidosis Mimicking Cancer at 18F-FDG PET/CT. 61
32149791 2020
26
Cutaneous sarcoidosis in 95 Japanese patients: a single institutional study. 61
32293564 2020
27
Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare. 61
31185230 2020
28
Treatment of Multiorgan Sarcoidosis With Tofacitinib. 61
31916703 2020
29
A Rare Case of Lichenoid Sarcoidosis Mimicking Papular Amyloidosis. 61
32029941 2020
30
Polymorphic Eruption of Extensive Cutaneous Sarcoidosis. 61
32790617 2020
31
Sudden Development of Subcutaneous Nodules Shortly after Radioiodine Treatment for Thyroid Cancer Caused by Self-Limiting Sarcoidosis. 61
32789128 2020
32
Necrobiosis Lipoidica Mimicking Cutaneous Sarcoidosis Finally Treated With an Intralesional Injection of Corticosteroid: A Case Report 61
32023016 2020
33
Responsiveness to Change and Establishment of the Minimal Clinically Important Difference for the Cutaneous Sarcoidosis Activity and Morphology Instrument. 61
31721981 2020
34
Cutaneous sarcoidosis: clinico-epidemiological profile of 72 patients at a tertiary hospital in São Paulo, Brazil. 61
31889592 2020
35
Gene Co-expression Networks Identifies Common Hub Genes Between Cutaneous Sarcoidosis and Discoid Lupus Erythematosus. 61
33324666 2020
36
Clinical Characteristics of Sarcoidosis in Asian Population: A 14-year Single Center Retrospective Cohort Study from Thailand. 61
33597798 2020
37
Verrucous sarcoidosis: a diagnosis to keep in mind. 61
33708319 2020
38
Brief Update on Dermatologic Uses of Methotrexate 61
31801013 2019
39
Visual Dermatology: Peculiar Form of Cutaneous Sarcoidosis. 61
31729911 2019
40
[Under the skin-A special manifestation of a systemic granulomatous disease]. 61
31506792 2019
41
Neurosarcoidosis presenting with a partial Claude syndrome. 61
31748369 2019
42
Periocular cutaneous sarcoid: case series and review of the literature. 61
31048763 2019
43
Uveoparotid fever as a presentation of sarcoidosis. 61
31656441 2019
44
Clinical and histopathological presentation and successful treatment with ciclosporin for canine sarcoidosis: a case report. 61
31328338 2019
45
Identification of Mycobacterium tuberculosis and non-tuberculous mycobacteria from cutaneous sarcoidosis lesions by reverse blot hybridization assay. 61
31392741 2019
46
Subcutaneous sarcoidosis of the upper and lower extremities: A case report and review of the literature. 61
31559285 2019
47
Sarcoidosis among hospitalized patients in Poland: a study based on a national hospital registry. 61
31436761 2019
48
First case of cutaneous sarcoidosis within tattoos under durvalumab. 61
31162632 2019
49
Natalizumab induced cutaneous sarcoidosis-like reaction. 61
31108403 2019
50
Cutaneous sarcoidosis presenting as a cutaneous horn. 61
31603974 2019
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Variations for Skin Sarcoidosis

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Expression for Skin Sarcoidosis

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Search GEO for disease gene expression data for Skin Sarcoidosis.
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Pathways for Skin Sarcoidosis

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Pathways related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.84 TNF IL2 IFNG IFNA1 CTLA4 CD8A
2
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.05 TNF IL2 IFNG IFNA1 ACE
3
Measles 36
Show member pathways
 12.67 TNF IL2 IFNG IFNA1
4
Allograft rejection 1 36
Show member pathways
 12.65 TNF IL2 IFNG IFNA1 CTLA4 CD8A
5
Immune response NFAT in immune response 23
Show member pathways
 12.51 TNF IL2 IFNG CD4
6
Th17 cell differentiation 36
Show member pathways
 12.48 TNF IL2 IFNG CD4
7
Immune response IL-23 signaling pathway 23
Show member pathways
 12.46 TNF IL2 IFNG CD4
8
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.39 TNF IL2 IFNG IFNA1
9
T cell receptor signaling pathway 36
Show member pathways
 12.34 TNF IL2 IFNG CTLA4 CD8A CD83
10
NF-kappaB Signaling 4
12.21 TNF IL2 IFNG IFNA1 CTLA4 CD8A
11
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.14 TNF IL2 IFNG IFNA1
12
Tuberculosis 36
12.1 TNF IFNG IFNA1
13
Necroptosis 36
Show member pathways
 12.07 TNF IFNG IFNA1
14
Cell adhesion molecules 36
12.01 CTLA4 CD8A CD4
15
Yersinia infection 36
11.99 TNF IL2 CD8A CD4
16
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 65
11.96 CD8A CD1C CD1B
17
Spinal Cord Injury 1
11.9 TNF IL2 IFNG
18
IL12-mediated signaling events 1
Show member pathways
 11.88 IL2 IFNG CD8A CD4
19
Amoebiasis 36
11.82 TNF IFNG CD1C CD1B
20
Hematopoietic cell lineage 36
11.8 TNF CD8A CD4 CD1C CD1B
21
Rheumatoid arthritis 36
11.77 TNF IFNG CTLA4
22
Th1 Differentiation Pathway 64
Show member pathways
 11.68 TNF IL2 IFNG CD4
23
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.66 TNF IL2 IFNG CTLA4
24
CTLA4 Signaling 63
11.64 CTLA4 CD8A CD4
25
Innate Lymphoid Cell Differentiation Pathways 64
11.62 TNF IL2 IFNG CD8A CD4
26
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.58 TNF IL2 IFNG
27
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.56 TNF IL2 IFNG CD8A CD83 CD4
28
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.54 TNF IL2 IFNG CD8A
29
Photodynamic therapy-induced AP-1 survival signaling. 1
11.48 TNF IL2 IFNG
30
Aryl Hydrocarbon Receptor Pathway 1
11.44 TNF IL2 IFNG
31
Th2 Differentiation Pathway 64
11.41 IL2 IFNG CD4
32
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.3 TNF IL2 IFNG
33
T-Cell Receptor and Co-stimulatory Signaling 1
11.23 IL2 CTLA4 CD8A
34
Cytokines and Inflammatory Response 1
11.2 TNF IL2 IFNG CD4
35
IL12 signaling mediated by STAT4 1
11.16 IL2 IFNG CD4
36
Dendritic Cells Developmental Lineage Pathway 64
11.04 TNF IL2 IFNG CD8A CD83 CD4
Sources

GO Terms for Skin Sarcoidosis

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Cellular components related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.63 TNF CTLA4 CD8A CD83 CD4 CD1C
2 extracellular space GO:0005615 9.5 TNF IL2 IFNG IFNA1 CD1C CD1B
3 external side of plasma membrane GO:0009897 9.23 TNF CTLA4 CD8A CD83 CD4 CD1C

Biological processes related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.88 IL2 CTLA4 CD8A CD4 CD1C CD1B
2 cytokine-mediated signaling pathway GO:0019221 9.83 TNF IL2 IFNA1 CD4
3 defense response GO:0006952 9.76 TNF IFNA1 CD83
4 positive regulation of protein phosphorylation GO:0001934 9.76 TNF IL2 IFNG CD4
5 positive regulation of inflammatory response GO:0050729 9.71 TNF IL2 IFNG
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 TNF IL2 IFNG
7 positive regulation of T cell mediated cytotoxicity GO:0001916 9.62 CD1C CD1B
8 T cell activation involved in immune response GO:0002286 9.61 IFNA1 CD1C
9 positive regulation of osteoclast differentiation GO:0045672 9.61 TNF IFNG
10 macrophage differentiation GO:0030225 9.6 IFNG CD4
11 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.59 IFNG IFNA1
12 positive regulation of amyloid-beta formation GO:1902004 9.58 TNF IFNG
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.57 TNF IFNG
14 astrocyte activation GO:0048143 9.56 TNF IFNG
15 immune response GO:0006955 9.56 TNF IL2 IFNG CTLA4 CD8A CD4
16 negative regulation of amyloid-beta clearance GO:1900222 9.55 TNF IFNG
17 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.51 CD1C CD1B
18 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.48 CD1C CD1B
19 humoral immune response GO:0006959 9.46 TNF IFNG IFNA1 CD83
20 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IFNG
21 regulation of regulatory T cell differentiation GO:0045589 9.43 IL2 IFNG CTLA4
22 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 TNF IFNG
23 positive regulation of nitrogen compound metabolic process GO:0051173 9.32 TNF IFNG
24 adaptive immune response GO:0002250 9.23 IL2 IFNG IFNA1 CTLA4 CD8A CD4

Molecular functions related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 TNF IL2 IFNG IFNA1
2 lipopeptide binding GO:0071723 9.26 CD1C CD1B
3 exogenous lipid antigen binding GO:0030884 8.96 CD1C CD1B
4 endogenous lipid antigen binding GO:0030883 8.62 CD1C CD1B
Sources

Sources for Skin Sarcoidosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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