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MCID: SKN006
MIFTS: 41

Skin Sarcoidosis

Categories: Immune diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Skin Sarcoidosis

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MalaCards integrated aliases for Skin Sarcoidosis:

Name: Skin Sarcoidosis 12 15 17
Cutaneous Sarcoidosis 12 71
Cutaneous Sarcoid 12

Classifications:

MalaCards categories:
Anatomical: Immune diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:13402
NCIt 49 C34996
SNOMED-CT 67 55941000
ICD10 32 D86.3
UMLS 71 C0036203
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Summaries for Skin Sarcoidosis

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MalaCards based summary : Skin Sarcoidosis, also known as cutaneous sarcoidosis, is related to pustulosis of palm and sole and alopecia. An important gene associated with Skin Sarcoidosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Allograft rejection and Immune response NFAT in immune response. The drugs Apremilast and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and t cells, and related phenotypes are endocrine/exocrine gland and hematopoietic system

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Related Diseases for Skin Sarcoidosis

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Diseases related to Skin Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 507)
# Related Disease Score Top Affiliating Genes
1 pustulosis of palm and sole 30.3 TNFRSF1B TNF
2 alopecia 30.2 TNF IL2 CTLA4
3 microscopic polyangiitis 30.1 TNF CTLA4
4 tuberculoid leprosy 30.1 IL2 CD4 CD1B
5 pulmonary sarcoidosis 30.0 TNF IL2 ACE
6 syphilis 29.9 TNF CD8A CD4 ACE
7 vasculitis 29.9 TNFRSF1B TNF CTLA4
8 cutaneous lupus erythematosus 29.7 TNF IFNA1 CTLA4
9 uveitis 29.7 TNFRSF1B TNF IL2 CTLA4
10 iridocyclitis 29.7 TNFRSF1B TNF CD4 ACE
11 allergic hypersensitivity disease 29.6 TNF IL2 CD4
12 crohn's disease 29.5 TNFRSF1B TNF IL2 CD4
13 hashimoto thyroiditis 29.4 TNF IL2 CTLA4
14 histoplasmosis 29.4 TNFRSF1B TNF CD8A CD4
15 necrobiosis lipoidica 29.3 TNFRSF1B TNF CD1E
16 sarcoidosis 1 29.3 TNFRSF1B TNF IL2 CD8A CD4 ACE
17 systemic scleroderma 29.3 TNF CD8A CD4 ACE
18 autoimmune disease 29.3 TNFRSF1B TNF IL2 IFNA1 CTLA4
19 neurosarcoidosis 29.3 TNFRSF1B TNF CD8A CD4 ACE
20 juvenile rheumatoid arthritis 29.3 TNFRSF1B TNF IL2 CTLA4
21 granulomatous dermatitis 29.3 TNFRSF1B TNF CD4 CD1B ACE
22 thyroiditis 29.3 TNF IL2 IFNA1 CTLA4
23 psoriatic arthritis 29.3 TNFRSF1B TNF IL2 CTLA4
24 immune deficiency disease 29.2 TNF IL2 IFNA1 CD4
25 vascular disease 29.2 TNF IL2 CD4 ACE
26 rheumatoid arthritis 29.2 TNFRSF1B TNF IL2 CTLA4 CD4
27 skin disease 29.1 TNFRSF1B TNF IL2 CTLA4 CD8A CD4
28 seborrheic dermatitis 29.1 TNF CD4 CD1E CD1B
29 mycosis fungoides 29.0 TNFRSF1B IL2 IFNA1 CTLA4 CD1B
30 vitiligo-associated multiple autoimmune disease susceptibility 1 29.0 IL2 CTLA4 CD8A CD4
31 eye disease 29.0 TNF IL2 CD8A CD4 ACE
32 folliculitis 29.0 TNF CD4 CD1E CD1B
33 common variable immunodeficiency 28.9 TNFRSF1B TNF IL2 CTLA4 CD83
34 primary biliary cirrhosis 28.9 TNF IL2 IFNA1 CTLA4 CD4
35 psoriasis 28.8 TNFRSF1B TNF IL2 CTLA4 CD4 ACE
36 aplastic anemia 28.8 TNF IL2 IFNA1 CTLA4 CD4
37 thymoma 28.7 TNF IL2 IFNA1 CTLA4 CD8A
38 autoimmune lymphoproliferative syndrome 28.7 TNF IL2 CTLA4 CD8A CD4
39 granuloma annulare 28.6 TNFRSF1B TNF CD4 CD1E CD1B
40 peripheral nervous system disease 28.5 TNFRSF1B TNF IL2 CD8A CD4 ACE
41 herpes zoster 28.4 TNFRSF1B TNF IL2 IFNA1 CD8A CD4
42 bone inflammation disease 28.4 TNFRSF1B TNF IL2 CTLA4 CD8A CD4
43 inflammatory bowel disease 28.3 TNFRSF1B TNF IL2 CTLA4 CD8A ACE
44 lymphoma, non-hodgkin, familial 28.3 TNFRSF1B TNF IL2 CTLA4 CD8A CD4
45 dermatitis, atopic 28.2 TNF IL2 CTLA4 CD8A CD83 CD4
46 leprosy 3 27.9 TNF IL2 CD8A CD4 CD1E CD1B
47 exanthem 27.6 TNFRSF1B TNF IL2 IFNA1 CTLA4 CD8A
48 blau syndrome 11.3
49 histoplasmosis pericarditis 10.5 TNF ACE
50 subacute cutaneous lupus erythematosus 10.5 TNF ACE

Graphical network of the top 20 diseases related to Skin Sarcoidosis:



Diseases related to Skin Sarcoidosis
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Symptoms & Phenotypes for Skin Sarcoidosis

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MGI Mouse Phenotypes related to Skin Sarcoidosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.56 ACE CD4 CD83 CD8A CTLA4 IL2
2 hematopoietic system MP:0005397 9.23 ACE CD4 CD83 CD8A CTLA4 IL2
Sources

Drugs & Therapeutics for Skin Sarcoidosis

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Drugs for Skin Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apremilast Approved, Investigational Phase 2, Phase 3 608141-41-9 11561674
2 Hormone Antagonists Phase 2, Phase 3
3 Adrenocorticotropic Hormone Phase 2, Phase 3
4 Melanocyte-Stimulating Hormones Phase 2, Phase 3
5 Hormones Phase 2, Phase 3
6 beta-Endorphin Phase 2, Phase 3
7 Immunologic Factors Phase 3
8 Angiogenesis Inhibitors Phase 3
9 Anti-Infective Agents Phase 3
10 Immunosuppressive Agents Phase 3
11 Anti-Bacterial Agents Phase 3
12
Rifampicin Approved Phase 1, Phase 2 13292-46-1 5381226 5458213
13
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
14
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583
15
Ethambutol Approved Phase 1, Phase 2 74-55-5 3279 14052
16
Azithromycin Approved Phase 1, Phase 2 83905-01-5 447043 55185
17
Ustekinumab Approved, Investigational Phase 2 815610-63-0
18 Antitubercular Agents Phase 1, Phase 2
19 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
20 Antibiotics, Antitubercular Phase 1, Phase 2
21 Dermatologic Agents Phase 2
22
Tofacitinib Approved, Investigational Phase 1 477600-75-2
23 Protein Kinase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ACTHAR Gel for Cutaneous Sarcoidosis: An Open Label Trial Unknown status NCT02348905 Phase 2, Phase 3 ACTHAR Gel 40 units twice weekly;ACTHAR Gel 80 units twice weekly.
2 The Efficacy and Safety of CC-10004 in Chronic Cutaneous Sarcoidosis Completed NCT00794274 Phase 2, Phase 3 CC-100004
3 Randomized Controlled Trial of Thalidomide vs Placebo in Skin Sarcoidosis Completed NCT00305552 Phase 3 THALIDOMIDE
4 A Double-Blind, Randomized, Placebo-Controlled Study of Adalimumab in the Treatment of Cutaneous Sarcoidosis Completed NCT00274352 Phase 2 adalimumab
5 Phase I/II Study of the Effects of Antibiotics on Sarcoidosis Pathogenesis Completed NCT01074554 Phase 1, Phase 2 Antibiotic Regimen;Placebo Regimen
6 A Phase 2, Multicenter, Randomized, Double-Blind, Parallel-group, Placebo-controlled Study Evaluating the Safety and Efficacy of Treatment With Ustekinumab or Golimumab in Subjects With Chronic Sarcoidosis Completed NCT00955279 Phase 2 Placebo;Golimumab;Ustekinumab
7 A Phase 2A, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Sequential, Dose-Ascending Study Of CC-220 In Subjects With Chronic Cutaneous Sarcoidosis Withdrawn NCT02192489 Phase 2 CC-220 0.3 mg Daily;CC-220 0.6mg Daily;Placebo
8 A Phase II, Multi-Center, Open Label Study to Determine the Efficacy of Adalimumab in the Treatment of Cutaneous Sarcoidosis (HUM 04-36) Withdrawn NCT00690911 Phase 2 adalimumab
9 A Phase II, Multi-Center, Open Label Study to Determine the Efficacy of Adalimumab in the Treatment of Cutaneous Sarcoidosis Withdrawn NCT00731757 Phase 2 Humira
10 Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare Active, not recruiting NCT03910543 Phase 1 Tofacitinib 5 mg twice daily

Search NIH Clinical Center for Skin Sarcoidosis

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Genetic Tests for Skin Sarcoidosis

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Anatomical Context for Skin Sarcoidosis

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MalaCards organs/tissues related to Skin Sarcoidosis:

40
Skin, Lung, T Cells, Bone, Lymph Node, Colon, Thyroid
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Publications for Skin Sarcoidosis

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Articles related to Skin Sarcoidosis:

(show top 50) (show all 630)
# Title Authors PMID Year
1
CD163-positive macrophage infiltration predicts systemic involvement in sarcoidosis. 61
32125018 2020
2
A prospective comparison of cutaneous sarcoidosis disease response to immunomodulatory and immunosuppressive therapies. 61
32151628 2020
3
Association of Propionibacterium acnes with the efficacy of minocycline therapy for cutaneous sarcoidosis. 61
32333400 2020
4
Colon Sarcoidosis Mimicking Cancer at 18F-FDG PET/CT. 61
32149791 2020
5
An unusual presentation of cutaneous sarcoidosis. 61
32385925 2020
6
Cutaneous sarcoidosis in 95 Japanese patients: a single institutional study. 61
32293564 2020
7
[Periorbital erythematous plaques and papules in an HIV-positive patient : A case report]. 61
32356073 2020
8
[Uveitis and tattoos]. 61
32296242 2020
9
Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare. 61
31185230 2020
10
Sarcoidosis with small syringotropic granulomas presenting clinically as a pigmented purpuric dermatosis: Inconspicuous clinical and histopathological clues to systemic illness. 61
32208528 2020
11
Treatment of Multiorgan Sarcoidosis With Tofacitinib. 61
31916703 2020
12
A Rare Case of Lichenoid Sarcoidosis Mimicking Papular Amyloidosis. 61
32029941 2020
13
Necrobiosis Lipoidica Mimicking Cutaneous Sarcoidosis Finally Treated With an Intralesional Injection of Corticosteroid: A Case Report 61
32023016 2020
14
Cutaneous sarcoidosis: clinico-epidemiological profile of 72 patients at a tertiary hospital in São Paulo, Brazil. 61
31889592 2020
15
Responsiveness to Change and Establishment of the Minimal Clinically Important Difference for the Cutaneous Sarcoidosis Activity and Morphology Instrument. 61
31721981 2019
16
[Under the skin-A special manifestation of a systemic granulomatous disease]. 61
31506792 2019
17
Visual Dermatology: Peculiar Form of Cutaneous Sarcoidosis. 61
31729911 2019
18
Brief Update on Dermatologic Uses of Methotrexate 61
31801013 2019
19
Neurosarcoidosis presenting with a partial Claude syndrome. 61
31748369 2019
20
Periocular cutaneous sarcoid: case series and review of the literature. 61
31048763 2019
21
Uveoparotid fever as a presentation of sarcoidosis. 61
31656441 2019
22
Identification of Mycobacterium tuberculosis and non-tuberculous mycobacteria from cutaneous sarcoidosis lesions by reverse blot hybridization assay. 61
31392741 2019
23
Clinical and histopathological presentation and successful treatment with ciclosporin for canine sarcoidosis: a case report. 61
31328338 2019
24
Sarcoidosis among hospitalized patients in Poland: a study based on a national hospital registry. 61
31436761 2019
25
Subcutaneous sarcoidosis of the upper and lower extremities: A case report and review of the literature. 61
31559285 2019
26
First case of cutaneous sarcoidosis within tattoos under durvalumab. 61
31162632 2019
27
Heerfordt syndrome developing in a patient with cutaneous sarcoidosis. 61
30623412 2019
28
Cutaneous sarcoidosis presenting as a cutaneous horn. 61
31603974 2019
29
Natalizumab induced cutaneous sarcoidosis-like reaction. 61
31108403 2019
30
Relevant diagnostic implications of the therapeutic challenge with antitubercular therapy in an unusual case of sarcoidosis mimicking lupus vulgaris. 61
31099451 2019
31
Clinical characteristics of sarcoidosis patients with systemic sclerosis-specific autoantibody: Possible involvement of thymus and activation-regulated chemokine and a review of the published works. 61
31131913 2019
32
Sarcoidosis with Multiorgan Involvement and Cutaneous Manifestations after Colonic Adenocarcinoma Resection. 61
31293305 2019
33
Biologic Therapy in the Treatment of Cutaneous Sarcoidosis: A Literature Review. 61
30895525 2019
34
Anti-tumor necrosis factor agents in sarcoidosis: A systematic review of efficacy and safety. 61
30446173 2019
35
A Rare Case of a Tuberculosis Patient with Sarcoidosis. 61
31301651 2019
36
Cardiac involvement in cutaneous sarcoidosis. 61
26376041 2019
37
Management of skin sarcoidosis with minocycline monotherapy. 61
30911395 2019
38
Foreign-Body Granulomata Caused by Injected Permanent Filler Masquerading as Cutaneous Sarcoidosis. 61
30921058 2019
39
Non-infectious granulomatous dermatoses. 61
31115996 2019
40
Bone marrow involvement in sarcoidosis: an elusive extrapulmonary manifestation. 61
31061693 2019
41
Resolution of cutaneous sarcoidosis after Janus kinase inhibitor therapy for concomitant polycythemia vera. 61
31008168 2019
42
Thrombocytopenia recovered by surgical resection of a myxoma. 61
30949250 2019
43
The natural history of cutaneous sarcoidosis. Clinical spectrum and histological analysis of 40 cases. 61
30306543 2019
44
In-vivo assessment of a case of cutaneous sarcoidosis using reflectance confocal microscopy. 61
30726472 2019
45
Physicochemical characterization of inorganic deposits associated with granulomas in cutaneous sarcoidosis. 61
29972866 2019
46
New-onset cutaneous sarcoidosis under tocilizumab treatment for giant cell arteritis: a quasi-paradoxical adverse drug reaction. Case report and literature review. 61
31019572 2019
47
Cutaneous sarcoidosis in a melanoma scar: A case report. 61
31555445 2019
48
Cutaneous sarcoidosis with livedo-like manifestation. 61
31644635 2019
49
Cutaneous sarcoidosis after Hodgkin lymphoma. 61
30411336 2019
50
Potassium Iodide for Cutaneous Inflammatory Disorders: A Monocentric, Retrospective Study. 61
30463069 2019
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Variations for Skin Sarcoidosis

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Expression for Skin Sarcoidosis

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Search GEO for disease gene expression data for Skin Sarcoidosis.
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Pathways for Skin Sarcoidosis

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Pathways related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 36
Show member pathways
 12.62 TNF IL2 IFNA1 CTLA4 CD8A CD4
2
Immune response NFAT in immune response 22
Show member pathways
 12.43 TNFRSF1B TNF IL2 CD4
3
T cell receptor signaling pathway 36
Show member pathways
 12.34 TNF IL2 CTLA4 CD8A CD83 CD4
4
Cell adhesion molecules (CAMs) 36
11.92 CTLA4 CD8A CD4
5
IL12-mediated signaling events 1
Show member pathways
 11.79 IL2 CD8A CD4
6
IL27-mediated signaling events 1
Show member pathways
 11.75 TNF IL2 CD4
7
Amoebiasis 36
11.72 TNF CD1E CD1B
8
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.72 TNF IL2 CD8A CD83 CD4
9
NF-kappaB Signaling 4
11.68 TNFRSF1B TNF IL2 IFNA1 CTLA4 CD8A
10
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.58 TNF IL2 CTLA4
11
Innate Lymphoid Cells Differentiation 64
11.57 TNF IL2 CD8A CD4
12
Hematopoietic cell lineage 36
11.55 TNF CD8A CD4 CD1E CD1B
13
CTLA4 Signaling 63
11.54 CTLA4 CD8A CD4
14
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.46 TNF IL2 CD8A
15
Dendritic Cells Developmental Lineage Pathway 64
11.22 TNF IL2 CD8A CD83 CD4
16
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.21 TNFRSF1B TNF IL2
17
T-Cell Receptor and Co-stimulatory Signaling 1
11.12 IL2 CTLA4 CD8A
18
Cytokines and Inflammatory Response 1
11.07 TNF IL2 CD4
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GO Terms for Skin Sarcoidosis

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Cellular components related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.85 YIPF4 TNFRSF1B TNF CTLA4 CD8A CD83
2 integral component of plasma membrane GO:0005887 9.73 TNF CTLA4 CD8A CD83 CD4 CD1E
3 plasma membrane GO:0005886 9.65 YIPF4 TNFRSF1B TNF CTLA4 CD8A CD83
4 external side of plasma membrane GO:0009897 9.23 TNF CTLA4 CD8A CD83 CD4 CD1E

Biological processes related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.73 IL2 CTLA4 CD8A CD4 CD1E CD1B
2 defense response GO:0006952 9.67 TNF IFNA1 CD83
3 cytokine-mediated signaling pathway GO:0019221 9.55 TNFRSF1B TNF IL2 IFNA1 CD4
4 humoral immune response GO:0006959 9.54 TNF IFNA1 CD83
5 adaptive immune response GO:0002250 9.5 IL2 IFNA1 CTLA4 CD8A CD4 CD1E
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.48 TNFRSF1B TNF
7 regulation of regulatory T cell differentiation GO:0045589 9.46 IL2 CTLA4
8 regulation of T cell proliferation GO:0042129 9.43 TNFRSF1B CTLA4
9 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.4 CD1E CD1B
10 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.32 CD1E CD1B
11 immune response GO:0006955 9.23 TNFRSF1B TNF IL2 CTLA4 CD8A CD4

Molecular functions related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.16 CD1E CD1B
2 exogenous lipid antigen binding GO:0030884 8.96 CD1E CD1B
3 endogenous lipid antigen binding GO:0030883 8.62 CD1E CD1B
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Sources for Skin Sarcoidosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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