MCID: SKN006
MIFTS: 43

Skin Sarcoidosis

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Skin Sarcoidosis

MalaCards integrated aliases for Skin Sarcoidosis:

Name: Skin Sarcoidosis 12 15
Cutaneous Sarcoidosis 12 73
Cutaneous Sarcoid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13402
ICD10 33 D86.3
NCIt 50 C34996
SNOMED-CT 68 55941000
UMLS 73 C0036203

Summaries for Skin Sarcoidosis

MalaCards based summary : Skin Sarcoidosis, also known as cutaneous sarcoidosis, is related to sarcoidosis 1 and vasculitis. An important gene associated with Skin Sarcoidosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are NF-kappaB Signaling and TNF signaling pathway. The drugs Apremilast and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and thyroid, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Skin Sarcoidosis

Diseases related to Skin Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 sarcoidosis 1 30.5 ACE TNF TNFRSF1B
2 vasculitis 29.3 TNF TNFRSF1B
3 blau syndrome 11.1
4 hepatitis 10.1
5 bladder neck obstruction 10.1 ACE TNFRSF1B
6 hepatitis c 10.1
7 uveoparotid fever 10.1 ACE TNF
8 subacute cutaneous lupus erythematosus 10.1 ACE TNF
9 posterior urethral valves 10.1 ACE TNF
10 ischemic heart disease 10.1 ACE TNF
11 juvenile ankylosing spondylitis 10.1 TNF TNFRSF1B
12 spondylitis 10.1 TNF TNFRSF1B
13 chronic gonococcal salpingitis 10.1 TNF TNFRSF1B
14 scleral disease 10.1 TNF TNFRSF1B
15 pustulosis of palm and sole 10.1 TNF TNFRSF1B
16 rheumatoid lung disease 10.1 TNF TNFRSF1B
17 extrinsic cardiomyopathy 10.1 ACE TNF
18 peroneal neuropathy 10.1 TNF TNFRSF1B
19 rheumatic heart disease 10.1 ACE TNF
20 periodic fever, familial, autosomal dominant 10.1 TNF TNFRSF1B
21 acute salpingitis 10.1 TNF TNFRSF1B
22 pyelonephritis 10.1 ACE TNF
23 post-transplant lymphoproliferative disease 10.1 TNF TNFRSF1B
24 limb ischemia 10.1 ACE TNF
25 chronic salpingitis 10.1 TNF TNFRSF1B
26 exanthem 10.1 TNF TNFRSF1B
27 silicosis 10.1 ACE TNF
28 panuveitis 10.1 TNF TNFRSF1B
29 carotid stenosis 10.1 ACE TNF
30 cogan syndrome 10.1 TNF TNFRSF1B
31 adult respiratory distress syndrome 10.1 ACE TNF
32 palindromic rheumatism 10.1 TNF TNFRSF1B
33 retinal vascular disease 10.1 ACE SERPINF1
34 pulmonary sarcoidosis 10.1 ACE TNF
35 uveal disease 10.1 TNF TNFRSF1B
36 pulmonary edema 10.1 ACE TNF
37 guillain-barre syndrome 10.1 TNF TNFRSF1B
38 sleep apnea 10.1 ACE TNF
39 eales disease 10.1 SERPINF1 TNF
40 end stage renal failure 10.1 ACE TNF
41 vascular dementia 10.1 ACE TNF
42 spondyloarthropathy 1 10.1 TNF TNFRSF1B
43 primary bacterial infectious disease 10.0 TNF TNFRSF1B
44 bone inflammation disease 10.0 TNF TNFRSF1B
45 microvascular complications of diabetes 5 10.0 ACE SERPINF1
46 arteries, anomalies of 10.0 ACE TNF
47 glucose metabolism disease 10.0 ACE TNF
48 juvenile rheumatoid arthritis 10.0 TNF TNFRSF1B
49 immune system disease 10.0 ACE TNF
50 otosclerosis 10.0 ACE SERPINF1

Graphical network of the top 20 diseases related to Skin Sarcoidosis:



Diseases related to Skin Sarcoidosis

Symptoms & Phenotypes for Skin Sarcoidosis

MGI Mouse Phenotypes related to Skin Sarcoidosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.77 ACE CD83 SERPINF1 TNF TNFRSF1B
2 endocrine/exocrine gland MP:0005379 9.72 ACE CD83 SERPINF1 TNF TNFRSF1B
3 hematopoietic system MP:0005397 9.65 ACE CD83 SERPINF1 TNF TNFRSF1B
4 immune system MP:0005387 9.55 ACE CD83 SERPINF1 TNF TNFRSF1B
5 liver/biliary system MP:0005370 9.26 ACE ADK TNF TNFRSF1B
6 vision/eye MP:0005391 8.92 ADK SERPINF1 TNF TNFRSF1B

Drugs & Therapeutics for Skin Sarcoidosis

Drugs for Skin Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apremilast Approved, Investigational Phase 2, Phase 3 608141-41-9 11561674
2 Neurotransmitter Agents Phase 2, Phase 3
3 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
4 Hormones Phase 2, Phase 3
5 beta-endorphin Phase 2, Phase 3
6 Melanocyte-Stimulating Hormones Phase 2, Phase 3
7 Hormone Antagonists Phase 2, Phase 3
8 Endorphins Phase 2, Phase 3
9 Adrenocorticotropic Hormone Phase 2, Phase 3
10 Immunologic Factors Phase 2, Phase 3,Phase 3
11 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3,Phase 1
12 Analgesics, Non-Narcotic Phase 2, Phase 3
13 Analgesics Phase 2, Phase 3
14 Peripheral Nervous System Agents Phase 2, Phase 3
15 Immunosuppressive Agents Phase 2, Phase 3,Phase 3
16 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
17 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
18 Anti-Inflammatory Agents Phase 2, Phase 3
19 Angiogenesis Modulating Agents Phase 2, Phase 3,Phase 3
20 Angiogenesis Inhibitors Phase 2, Phase 3,Phase 3
21 Antirheumatic Agents Phase 2, Phase 3
22
Adalimumab Approved Phase 2 331731-18-1 16219006
23
Azithromycin Approved Phase 1, Phase 2 83905-01-5 55185 447043
24
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
25
Ethambutol Approved Phase 1, Phase 2 74-55-5 3279 14052
26
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583
27
Rifampicin Approved Phase 1, Phase 2 13292-46-1 5458213 5381226
28
Ustekinumab Approved, Investigational Phase 2 815610-63-0
29 Cytochrome P-450 CYP3A Inducers Phase 1, Phase 2
30 Renal Agents Phase 1, Phase 2
31 Antitubercular Agents Phase 1, Phase 2
32 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
33 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
34 Cytochrome P-450 CYP1A2 Inhibitors Phase 1, Phase 2
35 Antibiotics, Antitubercular Phase 1, Phase 2
36 Topoisomerase Inhibitors Phase 1, Phase 2
37 Anti-Infective Agents, Urinary Phase 1, Phase 2
38 Dermatologic Agents Phase 2
39 Antibodies, Monoclonal Phase 2
40 Antibodies Phase 2
41 Immunoglobulins Phase 2
42
Maraviroc Approved, Investigational Not Applicable 376348-65-1 3002977
43 Antiviral Agents Not Applicable
44 Pharmaceutical Solutions Not Applicable
45 Anti-HIV Agents Not Applicable
46 Anesthetics Not Applicable
47 Anti-Retroviral Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ACTHAR Gel for Cutaneous Sarcoidosis: An Open Label Trial Unknown status NCT02348905 Phase 2, Phase 3 ACTHAR Gel 40 units twice weekly;ACTHAR Gel 80 units twice weekly.
2 The Efficacy and Safety of CC-10004 in Chronic Cutaneous Sarcoidosis Completed NCT00794274 Phase 2, Phase 3 CC-100004
3 SARCOTHAL. Thalidomide in Skin Sarcoidosis Completed NCT00305552 Phase 3 THALIDOMIDE
4 A Study of Adalimumab to Treat Sarcoidosis of the Skin Completed NCT00274352 Phase 2 adalimumab
5 Trial of Antimycobacterial Therapy in Sarcoidosis Completed NCT01074554 Phase 1, Phase 2 Antibiotic Regimen;Placebo Regimen
6 A Study to Evaluate the Safety and Effectiveness of Ustekinumab or Golimumab Administered Subcutaneously (SC) in Patients With Sarcoidosis Completed NCT00955279 Phase 2 Placebo;Golimumab;Ustekinumab
7 A Phase 2 Study With CC-220 in Skin Sarcoidosis Withdrawn NCT02192489 Phase 2 CC-220 0.3 mg Daily;CC-220 0.6mg Daily;Placebo
8 Efficacy Study of Humira in the Treatment of Cutaneous Sarcoidosis Withdrawn NCT00731757 Phase 2 Humira
9 Study to Determine the Efficacy of Adalimumab in the Treatment of Cutaneous Sarcoidosis Withdrawn NCT00690911 Phase 2 adalimumab
10 Impact of Chemokine Receptor 5 (CCR5) Inhibition on Sarcoidosis Immunophenotypes Terminated NCT02134717 Not Applicable all subjects will receive maraviroc 300mg orally twice a day for 6 weeks

Search NIH Clinical Center for Skin Sarcoidosis

Genetic Tests for Skin Sarcoidosis

Anatomical Context for Skin Sarcoidosis

MalaCards organs/tissues related to Skin Sarcoidosis:

41
Skin, Lung, Thyroid, T Cells, Bone, Heart, Myeloid

Publications for Skin Sarcoidosis

Articles related to Skin Sarcoidosis:

(show top 50) (show all 287)
# Title Authors Year
1
Cutaneous sarcoidosis after Hodgkin lymphoma. ( 30411336 )
2018
2
Polymorphous Cutaneous Sarcoidosis Associated with Peripheral Vascular Disease and its Dermatoscopic Findings. ( 30050815 )
2018
3
Concurrent Diagnoses of Cutaneous Sarcoidosis and Recurrent Metastatic Breast Cancer: More than a Coincidental Occurrence? ( 30254768 )
2018
4
Micropapular Cutaneous Sarcoidosis Reviewed. ( 30278434 )
2018
5
The natural history of cutaneous sarcoidosis. Clinical spectrum and histological analysis of 40 cases. ( 30306543 )
2018
6
Exploring the dynamic changes between pulmonary and cutaneous sarcoidosis based on gene expression. ( 30403187 )
2018
7
Oral Fumaderm® to treat cutaneous sarcoidosis. ( 29756252 )
2018
8
Cutaneous sarcoidosis: a new subset in the spectrum of paraneoplastic dermatoses. ( 29779211 )
2018
9
Physicochemical characterization of inorganic deposits associated with granulomas in cutaneous sarcoidosis. ( 29972866 )
2018
10
Dermoscopy of a single plaque on the face: an uncommon presentation of cutaneous sarcoidosis. ( 30116658 )
2018
11
Light and Laser Modalities in the Treatment of Cutaneous Sarcoidosis: A Systematic Review. ( 29242948 )
2018
12
Cutaneous sarcoidosis in a patient with rheumatoid arthritis receiving tocilizumab. ( 29500868 )
2018
13
Narrow-band UVB for pretibial (necrobiosis lipoidica-like) involvement of cutaneous sarcoidosis: a promising therapeutic option. ( 28681723 )
2017
14
Cutaneous sarcoidosis during rituximab treatment for microscopic polyangiitis: an uncommon adverse effect? ( 29165307 )
2017
15
A granulomatous conundrum: Concurrent necrobiosis lipoidica, cutaneous sarcoidosis and erythema nodosum in a nondiabetic patient. ( 28211041 )
2017
16
Cutaneous sarcoidosis and secondary open-angle glaucoma in a patient: case report and literature review. ( 29186261 )
2017
17
Annular lesions of cutaneous sarcoidosis with granulomatous vasculitis. ( 28116823 )
2017
18
Recalcitrant Diffuse Cutaneous Sarcoidosis With Perianal Involvement Responding to Adalimumab. ( 29240869 )
2017
19
Quantification of granuloma volume and response to treatment in cutaneous sarcoidosis using 3-dimensional high-frequency ultrasound scan. ( 29264382 )
2017
20
Annular cutaneous sarcoidosis with systemic involvement. ( 29417028 )
2017
21
Koebnerization phenomenon after broadband light therapy in a patient with cutaneous sarcoidosis. ( 28752117 )
2017
22
Cutaneous sarcoidosis: A retrospective case series and a hospital-based case-control study in Taiwan. ( 28984765 )
2017
23
Unconventional use of fractional ablative CO2 laser in facial cutaneous sarcoïdosis. ( 29082596 )
2017
24
An Adolescent with Extensive Cutaneous Sarcoidosis without Lung Involvement. ( 28213883 )
2017
25
Nivolumab-related cutaneous sarcoidosis in a patient with lung adenocarcinoma. ( 28443311 )
2017
26
Efficacy and Tolerance of Anti-Tumor Necrosis Factor α Agents in Cutaneous Sarcoidosis: A French Study of 46 Cases. ( 28564695 )
2017
27
Cutaneous sarcoidosis. ( 28598873 )
2017
28
High frequency ultrasound: a novel instrument to quantify granuloma burden in cutaneous sarcoidosis. ( 29628755 )
2017
29
A case of hyaluronic acid injections triggering cutaneous sarcoidosis at previously treated sites. ( 27357733 )
2017
30
Resolution of Cutaneous Sarcoidosis Following Topical Application of Ganoderma lucidum (Reishi Mushroom). ( 26868374 )
2016
31
Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report. ( 27646659 )
2016
32
Cutaneous sarcoidosis and macular amyloidosis occurring at the same site. ( 27297271 )
2016
33
Plantar subcutaneous sarcoidosisA -A a rare form of skin sarcoidosis: unusual plantar aponeurosis location of sarcoidosis as primary manifestation of asymptomatic systemic disease. ( 26865475 )
2016
34
Is it a sarcoidal foreign-body granuloma or a cutaneous sarcoidosis on a permanent eyebrow make-up? ( 26073118 )
2016
35
Epidemiology of cutaneous sarcoidosis, 1976-2013: a population-based study from Olmsted County, Minnesota. ( 27324138 )
2016
36
Development of exclusively cutaneous sarcoidosis in patient with rheumatoid arthritis during treatment with etanercept. ( 27992009 )
2016
37
Cutaneous Sarcoidosis Misdiagnosed as Leprosy. Report of Two Cases and Review of Literature. ( 30207442 )
2016
38
Isolated Cutaneous Sarcoidosis. ( 26552871 )
2016
39
Cutaneous sarcoidosis at insulin injection sites. ( 26783329 )
2016
40
Infliximab for chronic cutaneous sarcoidosis: a subset analysis from a double-blind randomized clinical trial. ( 26847095 )
2016
41
Erythematous patches and pretibial ulcers: an uncommon presentation of cutaneous sarcoidosis. ( 26972195 )
2016
42
Cutaneous sarcoidosis with zosteriform distribution and pulmonary involvement. ( 27176087 )
2016
43
Cutaneous sarcoidosis in a melanoma patient under Ipilimumab therapy. ( 27357143 )
2016
44
Cutaneous sarcoidosis with granuloma formation around nerves mimicking mycobacterial infection. ( 25869122 )
2015
45
Cutaneous sarcoidosis simulating porokeratosis of Mibelli. ( 26113926 )
2015
46
A rare comorbidity: neurosarcoidosis and cutaneous sarcoidosis. ( 26578505 )
2015
47
Perineural granulomas in cutaneous sarcoidosis may be associated with sarcoidosis small fiber neuropathy. ( 25757612 )
2015
48
Response to letter "evaluation of cardiac involvement in caucasian patients with skin sarcoidosis". ( 25581211 )
2015
49
Evaluation of cardiac involvement in caucasian patients with skin sarcoidosis. ( 25598240 )
2015
50
Cutaneous Sarcoidosis: Preamble of a Paucisymptomatic Systemic Disease. ( 25823568 )
2015

Variations for Skin Sarcoidosis

Expression for Skin Sarcoidosis

Search GEO for disease gene expression data for Skin Sarcoidosis.

Pathways for Skin Sarcoidosis

GO Terms for Skin Sarcoidosis

Cellular components related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 ACE CD83 TNF

Biological processes related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 9.4 SERPINF1 TNFRSF1B
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.37 TNF TNFRSF1B
3 humoral immune response GO:0006959 9.32 CD83 TNF
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.26 TNF TNFRSF1B
5 extrinsic apoptotic signaling pathway GO:0097191 9.16 TNF TNFRSF1B
6 negative regulation of gene expression GO:0010629 9.13 ACE SERPINF1 TNF
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.62 TNF TNFRSF1B

Sources for Skin Sarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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