MCID: SKN006
MIFTS: 40

Skin Sarcoidosis

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Skin Sarcoidosis

MalaCards integrated aliases for Skin Sarcoidosis:

Name: Skin Sarcoidosis 12 15
Cutaneous Sarcoidosis 12 73
Cutaneous Sarcoid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13402
ICD10 33 D86.3
NCIt 50 C34996
SNOMED-CT 68 187234008 55941000
UMLS 73 C0036203

Summaries for Skin Sarcoidosis

MalaCards based summary : Skin Sarcoidosis, also known as cutaneous sarcoidosis, is related to blau syndrome and granulomatous hepatitis. An important gene associated with Skin Sarcoidosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are NF-kappaB Signaling and TNF signaling pathway. The drugs Apremilast and beta-endorphin have been mentioned in the context of this disorder. Affiliated tissues include skin and thyroid, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Skin Sarcoidosis

Diseases related to Skin Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 blau syndrome 11.0
2 granulomatous hepatitis 10.4 ACE TNFRSF1B
3 subacute cutaneous lupus erythematosus 10.4 ACE TNF
4 granulomatous dermatitis 10.4 ACE TNF
5 posterior urethral valves 10.4 ACE TNF
6 ischemic heart disease 10.4 ACE TNF
7 systolic heart failure 10.3 ACE TNF
8 rheumatoid lung disease 10.3 TNF TNFRSF1B
9 extrinsic cardiomyopathy 10.3 ACE TNF
10 chronic gonococcal salpingitis 10.3 TNF TNFRSF1B
11 scleral disease 10.3 TNF TNFRSF1B
12 pustulosis of palm and sole 10.3 TNF TNFRSF1B
13 peroneal neuropathy 10.3 TNF TNFRSF1B
14 rheumatic heart disease 10.3 ACE TNF
15 periodic fever, familial, autosomal dominant 10.3 TNF TNFRSF1B
16 sweat gland disease 10.3 TNF TNFRSF1B
17 pyelonephritis 10.3 ACE TNF
18 limb ischemia 10.3 ACE TNF
19 acute salpingitis 10.3 TNF TNFRSF1B
20 post-transplant lymphoproliferative disease 10.3 TNF TNFRSF1B
21 chronic salpingitis 10.3 TNF TNFRSF1B
22 silicosis 10.3 ACE TNF
23 panuveitis 10.3 TNF TNFRSF1B
24 adult respiratory distress syndrome 10.3 ACE TNF
25 palindromic rheumatism 10.3 TNF TNFRSF1B
26 pulmonary edema 10.3 ACE TNF
27 carotid stenosis 10.3 ACE TNF
28 exanthem 10.3 TNF TNFRSF1B
29 cogan syndrome 10.3 TNF TNFRSF1B
30 pulmonary sarcoidosis 10.3 ACE TNF
31 guillain-barre syndrome 10.2 TNF TNFRSF1B
32 hypersensitivity reaction disease 10.2 ACE TNF
33 spondyloarthropathy 1 10.2 TNF TNFRSF1B
34 sleep apnea 10.2 ACE TNF
35 eales disease 10.2 SERPINF1 TNF
36 primary bacterial infectious disease 10.2 TNF TNFRSF1B
37 bone inflammation disease 10.2 TNF TNFRSF1B
38 end stage renal failure 10.2 ACE TNF
39 intestinal disease 10.2 TNF TNFRSF1B
40 vascular dementia 10.2 ACE TNF
41 microvascular complications of diabetes 5 10.2 ACE SERPINF1
42 spondylitis 10.1 TNF TNFRSF1B
43 juvenile rheumatoid arthritis 10.1 TNF TNFRSF1B
44 glucose metabolism disease 10.1 ACE TNF
45 urinary system disease 10.1 ACE TNF
46 arteries, anomalies of 10.1 ACE TNF
47 otosclerosis 10.1 ACE SERPINF1
48 immune system disease 10.0 ACE TNF
49 membranous nephropathy 10.0 ACE TNF
50 chagas disease 10.0 ACE TNF

Graphical network of the top 20 diseases related to Skin Sarcoidosis:



Diseases related to Skin Sarcoidosis

Symptoms & Phenotypes for Skin Sarcoidosis

MGI Mouse Phenotypes related to Skin Sarcoidosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.77 TNF TNFRSF1B ACE CD83 SERPINF1
2 endocrine/exocrine gland MP:0005379 9.72 TNF TNFRSF1B ACE CD83 SERPINF1
3 hematopoietic system MP:0005397 9.65 SERPINF1 TNF TNFRSF1B ACE CD83
4 immune system MP:0005387 9.55 SERPINF1 TNF TNFRSF1B ACE CD83
5 liver/biliary system MP:0005370 9.26 TNF TNFRSF1B ACE ADK
6 vision/eye MP:0005391 8.92 SERPINF1 TNF TNFRSF1B ADK

Drugs & Therapeutics for Skin Sarcoidosis

Drugs for Skin Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apremilast Approved, Investigational Phase 2, Phase 3 608141-41-9 11561674
2 beta-endorphin Phase 2, Phase 3
3 Adrenocorticotropic Hormone Phase 2, Phase 3
4 Neurotransmitter Agents Phase 2, Phase 3
5 Hormone Antagonists Phase 2, Phase 3
6 Hormones Phase 2, Phase 3
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
8 Endorphins Phase 2, Phase 3
9 Melanocyte-Stimulating Hormones Phase 2, Phase 3
10 Analgesics Phase 2, Phase 3
11 Analgesics, Non-Narcotic Phase 2, Phase 3
12 Angiogenesis Inhibitors Phase 2, Phase 3,Phase 3
13 Angiogenesis Modulating Agents Phase 2, Phase 3,Phase 3
14 Peripheral Nervous System Agents Phase 2, Phase 3
15 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3,Phase 1
16 Immunosuppressive Agents Phase 2, Phase 3,Phase 3
17 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
18 Anti-Inflammatory Agents Phase 2, Phase 3
19 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
20 Antirheumatic Agents Phase 2, Phase 3
21
Rifampicin Approved Phase 1, Phase 2 13292-46-1 5458213 5381226
22
Azithromycin Approved Phase 1, Phase 2 83905-01-5 55185 447043
23
Ethambutol Approved Phase 1, Phase 2 74-55-5 3279 14052
24
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583
25
Adalimumab Approved Phase 2 331731-18-1 16219006
26
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
27
Ustekinumab Approved, Investigational Phase 2 815610-63-0
28 Renal Agents Phase 1, Phase 2
29 Cytochrome P-450 CYP1A2 Inhibitors Phase 1, Phase 2
30 Cytochrome P-450 CYP3A Inducers Phase 1, Phase 2
31 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
32 Topoisomerase Inhibitors Phase 1, Phase 2
33 Dermatologic Agents Phase 2
34 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
35 Antibiotics, Antitubercular Phase 1, Phase 2
36 Antibodies Phase 2
37 Immunoglobulins Phase 2
38 Antibodies, Monoclonal Phase 2
39 Antitubercular Agents Phase 1, Phase 2
40
Maraviroc Approved, Investigational Not Applicable 376348-65-1 3002977
41 Anesthetics Not Applicable
42 Pharmaceutical Solutions Not Applicable
43 Anti-HIV Agents Not Applicable
44 Anti-Retroviral Agents Not Applicable
45 Antiviral Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ACTHAR Gel for Cutaneous Sarcoidosis: An Open Label Trial Unknown status NCT02348905 Phase 2, Phase 3 ACTHAR Gel 40 units twice weekly;ACTHAR Gel 80 units twice weekly.
2 The Efficacy and Safety of CC-10004 in Chronic Cutaneous Sarcoidosis Completed NCT00794274 Phase 2, Phase 3 CC-100004
3 SARCOTHAL. Thalidomide in Skin Sarcoidosis Completed NCT00305552 Phase 3 THALIDOMIDE
4 A Study of Adalimumab to Treat Sarcoidosis of the Skin Completed NCT00274352 Phase 2 adalimumab
5 Trial of Antimycobacterial Therapy in Sarcoidosis Completed NCT01074554 Phase 1, Phase 2 Antibiotic Regimen;Placebo Regimen
6 A Study to Evaluate the Safety and Effectiveness of Ustekinumab or Golimumab Administered Subcutaneously (SC) in Patients With Sarcoidosis Completed NCT00955279 Phase 2 Placebo;Golimumab;Ustekinumab
7 A Phase 2 Study With CC-220 in Skin Sarcoidosis Withdrawn NCT02192489 Phase 2 CC-220 0.3 mg Daily;CC-220 0.6mg Daily;Placebo
8 Efficacy Study of Humira in the Treatment of Cutaneous Sarcoidosis Withdrawn NCT00731757 Phase 2 Humira
9 Study to Determine the Efficacy of Adalimumab in the Treatment of Cutaneous Sarcoidosis Withdrawn NCT00690911 Phase 2 adalimumab
10 Impact of Chemokine Receptor 5 (CCR5) Inhibition on Sarcoidosis Immunophenotypes Terminated NCT02134717 Not Applicable all subjects will receive maraviroc 300mg orally twice a day for 6 weeks

Search NIH Clinical Center for Skin Sarcoidosis

Genetic Tests for Skin Sarcoidosis

Anatomical Context for Skin Sarcoidosis

MalaCards organs/tissues related to Skin Sarcoidosis:

41
Skin, Thyroid

Publications for Skin Sarcoidosis

Articles related to Skin Sarcoidosis:

(show top 50) (show all 61)
# Title Authors Year
1
Narrow-band UVB for pretibial (necrobiosis lipoidica-like) involvement of cutaneous sarcoidosis: a promising therapeutic option. ( 28681723 )
2017
2
Cutaneous sarcoidosis during rituximab treatment for microscopic polyangiitis: an uncommon adverse effect? ( 29165307 )
2017
3
A granulomatous conundrum: Concurrent necrobiosis lipoidica, cutaneous sarcoidosis and erythema nodosum in a nondiabetic patient. ( 28211041 )
2017
4
Resolution of Cutaneous Sarcoidosis Following Topical Application of Ganoderma lucidum (Reishi Mushroom). ( 26868374 )
2016
5
Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report. ( 27646659 )
2016
6
Cutaneous sarcoidosis and macular amyloidosis occurring at the same site. ( 27297271 )
2016
7
Plantar subcutaneous sarcoidosisA -A a rare form of skin sarcoidosis: unusual plantar aponeurosis location of sarcoidosis as primary manifestation of asymptomatic systemic disease. ( 26865475 )
2016
8
Is it a sarcoidal foreign-body granuloma or a cutaneous sarcoidosis on a permanent eyebrow make-up? ( 26073118 )
2016
9
Cutaneous sarcoidosis with granuloma formation around nerves mimicking mycobacterial infection. ( 25869122 )
2015
10
Cutaneous sarcoidosis simulating porokeratosis of Mibelli. ( 26113926 )
2015
11
A rare comorbidity: neurosarcoidosis and cutaneous sarcoidosis. ( 26578505 )
2015
12
Perineural granulomas in cutaneous sarcoidosis may be associated with sarcoidosis small fiber neuropathy. ( 25757612 )
2015
13
Evaluation of cardiac involvement in caucasian patients with skin sarcoidosis. ( 25598240 )
2015
14
Cutaneous Sarcoidosis: Preamble of a Paucisymptomatic Systemic Disease. ( 25823568 )
2015
15
Successful application of a novel dressing for the treatment of ulcerative cutaneous sarcoidosis. ( 24033979 )
2013
16
A syringotropic variant of cutaneous sarcoidosis: presentation of 3 cases exhibiting defective sweating responses. ( 23374232 )
2013
17
Cutaneous sarcoidosis and infliximab: evidence for efficacy in refractory disease. ( 23651297 )
2013
18
Isolated cutaneous sarcoidosis: a new insight into the old entity. ( 24086892 )
2013
19
Cutaneous sarcoidosis in a chronic hepatitis C patient receiving pegylated interferon and ribavirin therapy. ( 23675767 )
2013
20
Oral minocycline in treatment of cutaneous sarcoidosis. ( 23783160 )
2013
21
Comparison of cutaneous sarcoidosis with systemic sarcoidosis: a retrospective analysis. ( 24427359 )
2013
22
Diagnosis of cutaneous sarcoidosis; clinical and the prognostic significance of skin lesions. ( 23521826 )
2013
23
Exacerbation of recalcitrant cutaneous sarcoidosis with adalimumab - a paradoxical effect? A case report. ( 24346872 )
2013
24
Reliability and convergent validity of the cutaneous sarcoidosis activity and morphology instrument for assessing cutaneous sarcoidosis. ( 23677081 )
2013
25
Cutaneous sarcoidosis with livedoid lesions: evidence of the involvement of Propionibacterium acnes. ( 23731481 )
2013
26
Granulomatous cutaneous sarcoidosis: diagnosis, relationship to systemic disease, prognosis and treatment. ( 24351618 )
2013
27
Oral antimycobacterial therapy in chronic cutaneous sarcoidosis: a randomized, single-masked, placebo-controlled study. ( 23863960 )
2013
28
A double-blind, randomized, placebo-controlled trial of adalimumab in the treatment of cutaneous sarcoidosis. ( 23276549 )
2013
29
Verrucous cutaneous sarcoidosis: case report and review of this unusual variant of cutaneous sarcoidosis. ( 23344007 )
2013
30
A case series of refractory cutaneous sarcoidosis successfully treated with infliximab. ( 23205333 )
2012
31
Development of cutaneous sarcoidosis during treatment with tumour necrosis alpha factor antagonists. ( 23157794 )
2012
32
Unusual manifestation of cutaneous sarcoidosis: a case report of morpheaform sarcoidosis. ( 23165817 )
2012
33
Genetic predisposition to cutaneous sarcoidosis. ( 23275292 )
2012
34
Pleomorphic cutaneous sarcoidosis confined to lesions of vitiligo vulgaris in a patient with type 1 diabetes mellitus. ( 23075651 )
2012
35
Cutaneous sarcoidosis clinically mimicking necrobiosis lipoidica in a patient with systemic sarcoidosis. ( 22363160 )
2012
36
Pulmonary and cutaneous sarcoidosis in a treated case of renal tuberculosis. ( 22421674 )
2012
37
Clinical and histopathological analysis of specific lesions of cutaneous sarcoidosis in Korean patients. ( 20524878 )
2011
38
Hansen's disease: an imitator of cutaneous sarcoidosis. ( 21963758 )
2011
39
Cutaneous sarcoidosis in a woman with chronic hepatitis C and interferon therapy: a case report. ( 21053557 )
2010
40
Atrophic sarcoidosis: an unusual presentation of cutaneous sarcoidosis. ( 20839429 )
2010
41
A rare case of pulmonary tuberculosis with simultaneous pulmonary and skin sarcoidosis: a case report. ( 20205764 )
2010
42
Refractory chronic cutaneous sarcoidosis responsive to dose escalation of TNF-alpha antagonists. ( 19468200 )
2009
43
Hepatic, ocular, and cutaneous sarcoidosis. ( 18539241 )
2008
44
Clinical resolution of facial cutaneous sarcoidosis with systemic colchicine and a topical corticosteroid ointment. ( 18833787 )
2008
45
Cutaneous sarcoidosis successfully treated with alefacept. ( 17241600 )
2006
46
Cutaneous sarcoidosis masquerading as lepromatous leprosy. ( 17402349 )
2006
47
Newer therapies for cutaneous sarcoidosis: the role of thalidomide and other agents. ( 15663335 )
2004
48
The use of infliximab in cutaneous sarcoidosis. ( 12884466 )
2003
49
Progressive cutaneous sarcoidosis responding to anti-tumor necrosis factor-alpha therapy. ( 12582407 )
2003
50
Cutaneous sarcoidosis. ( 16088652 )
2002

Variations for Skin Sarcoidosis

Expression for Skin Sarcoidosis

Search GEO for disease gene expression data for Skin Sarcoidosis.

Pathways for Skin Sarcoidosis

GO Terms for Skin Sarcoidosis

Cellular components related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 ACE CD83 TNF

Biological processes related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 9.4 SERPINF1 TNFRSF1B
2 kidney development GO:0001822 9.37 ACE SERPINF1
3 apoptotic signaling pathway GO:0097190 9.32 TNF TNFRSF1B
4 humoral immune response GO:0006959 9.26 CD83 TNF
5 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.16 TNF TNFRSF1B
6 extrinsic apoptotic signaling pathway GO:0097191 8.96 TNF TNFRSF1B
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.62 TNF TNFRSF1B

Sources for Skin Sarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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