MCID: SKN006
MIFTS: 44

Skin Sarcoidosis

Categories: Immune diseases, Skin diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Skin Sarcoidosis

MalaCards integrated aliases for Skin Sarcoidosis:

Name: Skin Sarcoidosis 11 14 16
Cutaneous Sarcoidosis 11 71 33
Sarcoidosis of Skin 33
Cutaneous Sarcoid 11

Classifications:



External Ids:

Disease Ontology 11 DOID:13402
NCIt 49 C34996
SNOMED-CT 68 55941000
ICD10 31 D86.3
ICD11 33 1145144140
UMLS 71 C0036203

Summaries for Skin Sarcoidosis

MalaCards based summary: Skin Sarcoidosis, also known as cutaneous sarcoidosis, is related to neurosarcoidosis and granulomatous angiitis. An important gene associated with Skin Sarcoidosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Apremilast and Thalidomide have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and t cells, and related phenotypes are endocrine/exocrine gland and immune system

Related Diseases for Skin Sarcoidosis

Diseases related to Skin Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 908)
# Related Disease Score Top Affiliating Genes
1 neurosarcoidosis 29.9 TNF CD8A CD4 ACE
2 granulomatous angiitis 29.9 CD8A CD4 ACE
3 coccidioidomycosis 29.8 IL17A CD4 CCR6
4 pyoderma 29.8 TNF IL17A CCR6
5 tuberculoid leprosy 29.7 TNF IL2 IFNG CD8A CD4 CCR6
6 histoplasmosis 29.7 TNF IFNG CD4 CCR6
7 granulomatous dermatitis 29.7 TNF CD8A CD4 ACE
8 syphilis 29.7 TNF IL17A CD8A CD4 CCR6 ACE
9 dermatophytosis 29.7 TNF IL17A CD4 CCR6
10 seborrheic dermatitis 29.7 TNF IL17A CD4 CCR6
11 lymphoproliferative syndrome 29.6 JAK1 IL2 CTLA4 CCR6
12 chronic granulomatous disease 29.6 TNF IFNG CD8A CD4
13 rosacea 29.6 TNF IL6 IL17A
14 psoriasis 1 29.5 IL17A CCR6
15 peripheral vascular disease 29.5 TNF IL6 ACE
16 pulmonary sarcoidosis 29.4 TNF IL6 IL2 IFNG ACE
17 lepromatous leprosy 29.4 TNF IL2 IFNG CD8A CD4 CCR6
18 primary cutaneous t-cell non-hodgkin lymphoma 29.4 IL2 IFNG IFNA1 CD4 CCR6
19 inflammatory bowel disease 1 29.4 TNF IL6 IL17A CCR6
20 hashimoto thyroiditis 29.4 IFNG CTLA4 CD8A CD4 CCR6
21 allergic asthma 29.4 IL17A IFNG CTLA4 CCR6
22 folliculitis 29.3 TNF IL17A IFNG CD4 CCR6
23 granuloma annulare 29.3 TNF IL17A CD8A CD4 ACE
24 mycosis fungoides 29.3 IL2 IFNG IFNA1 CTLA4 CCR6
25 cutaneous leishmaniasis 29.3 TNF IL2 IFNG CD8A CD4 CCR6
26 pulmonary tuberculosis 29.3 TNF IL6 IL2 IFNG
27 erythema nodosum 29.3 TNF IL6 IFNG CTLA4
28 erythema multiforme 29.3 TNF IL6 IL2 IFNG
29 alopecia 29.2 TNF IL6 IL2 IL17A IFNG CTLA4
30 hypersensitivity vasculitis 29.1 TNF IL6 CD4 CCR6 ACE
31 polycythemia vera 29.1 TNF JAK1 IL6 IFNA1
32 juvenile rheumatoid arthritis 29.1 TNF IL6 IL2 CD4 CCR6
33 myelofibrosis 29.1 TNF JAK1 IL17A IFNA1
34 vasculitis 29.1 TNF IL6 IL17A CTLA4
35 uveitis 29.0 TNF IL6 IL2 IL17A IFNG CTLA4
36 lymphopenia 29.0 IL6 IL2 IFNG CTLA4 CCR6
37 common variable immunodeficiency 29.0 TNF IL6 IL2 IFNG CTLA4
38 urticaria 29.0 TNF IL6 IL17A IFNG CD4 ACE
39 ileitis 29.0 TNF IL6 IL17A CD4 CCR6
40 purpura 28.9 TNF IL6 IL2 IL17A IFNG
41 localized scleroderma 28.9 TNF IL6 IL17A CD8A CD4
42 essential thrombocythemia 28.9 JAK1 IL6 IFNA1 ACE
43 lichen planus 28.9 TNF IL6 IL2 IL17A IFNG
44 psoriatic arthritis 28.9 TNF PDE4A IL6 IL17A CCR6
45 actinic keratosis 28.8 TNF IL6 IFNA1 CD8A CD4
46 aplastic anemia 28.8 TNF IL6 IFNG CD8A CD4 CCR6
47 sarcoidosis 1 28.8 TNF IL6 IL2 IL17A IFNG CD8A
48 vitiligo-associated multiple autoimmune disease susceptibility 1 28.7 TNF IL2 IL17A CTLA4 CD8A CD4
49 spondyloarthropathy 1 28.7 TNF IL6 IL17A CD8A CD4 CCR6
50 keratitis, hereditary 28.7 TNF IL6 IL17A CD8A CD4 CCR6

Graphical network of the top 20 diseases related to Skin Sarcoidosis:



Diseases related to Skin Sarcoidosis

Symptoms & Phenotypes for Skin Sarcoidosis

MGI Mouse Phenotypes related to Skin Sarcoidosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.1 ACE CD4 CD8A CTLA4 IFNG IL17A
2 immune system MP:0005387 10.07 ACE CCR6 CD4 CD8A CTLA4 IFNA1
3 liver/biliary system MP:0005370 10.03 ACE CTLA4 IFNG IL17A IL2 IL6
4 cardiovascular system MP:0005385 9.97 ACE CCR6 CTLA4 IFNG IL2 IL6
5 digestive/alimentary MP:0005381 9.91 CD4 CTLA4 IFNG IL17A IL2 IL6
6 respiratory system MP:0005388 9.76 CTLA4 IFNA1 IFNG IL17A IL2 IL6
7 hematopoietic system MP:0005397 9.73 ACE CCR6 CD4 CD8A CTLA4 IFNA1
8 integument MP:0010771 9.23 CD4 CD8A CTLA4 IFNG IL17A IL6

Drugs & Therapeutics for Skin Sarcoidosis

Drugs for Skin Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apremilast Approved, Investigational Phase 2, Phase 3 608141-41-9 10151715 11561674
2
Thalidomide Approved, Investigational, Withdrawn Phase 3 50-35-1 5426
3 Melanocyte-Stimulating Hormones Phase 2, Phase 3
4 Adrenocorticotropic Hormone Phase 2, Phase 3
5
beta-Endorphin Phase 2, Phase 3
6 Hormones Phase 2, Phase 3
7 Hormone Antagonists Phase 2, Phase 3
8 Anti-Bacterial Agents Phase 3
9 Anti-Infective Agents Phase 3
10 Immunosuppressive Agents Phase 3
11 Immunologic Factors Phase 3
12 Angiogenesis Inhibitors Phase 3
13
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030
14
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
15
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
16 Antifungal Agents Phase 2
17 Antibiotics, Antitubercular Phase 2
18
Tofacitinib Approved, Investigational Phase 1 477600-75-2 9926791
19 Protein Kinase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ACTHAR Gel for Cutaneous Sarcoidosis: An Open Label Trial Unknown status NCT02348905 Phase 2, Phase 3 ACTHAR Gel 40 units twice weekly;ACTHAR Gel 80 units twice weekly.
2 The Efficacy and Safety of CC-10004 in Chronic Cutaneous Sarcoidosis Completed NCT00794274 Phase 2, Phase 3 CC-100004
3 Randomized Controlled Trial of Thalidomide vs Placebo in Skin Sarcoidosis Completed NCT00305552 Phase 3 THALIDOMIDE
4 A Double-Blind, Randomized, Placebo-Controlled Study of Adalimumab in the Treatment of Cutaneous Sarcoidosis Completed NCT00274352 Phase 2 adalimumab
5 Cutaneous Sarcoidosis With Moderate to Severe Involvement of the Face : Multicenter Open-label Study of Oral Sirolimus Efficacy and Tolerance Not yet recruiting NCT05458492 Phase 2 Sirolimus
6 A Phase II, Multi-Center, Open Label Study to Determine the Efficacy of Adalimumab in the Treatment of Cutaneous Sarcoidosis (HUM 04-36) Withdrawn NCT00690911 Phase 2 adalimumab
7 A Phase II, Multi-Center, Open Label Study to Determine the Efficacy of Adalimumab in the Treatment of Cutaneous Sarcoidosis Withdrawn NCT00731757 Phase 2 Humira
8 A Phase 2A, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Sequential, Dose-Ascending Study Of CC-220 In Subjects With Chronic Cutaneous Sarcoidosis Withdrawn NCT02192489 Phase 2 CC-220 0.3 mg Daily;CC-220 0.6mg Daily;Placebo
9 Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare Completed NCT03910543 Phase 1 Tofacitinib 5 mg twice daily

Search NIH Clinical Center for Skin Sarcoidosis

Genetic Tests for Skin Sarcoidosis

Anatomical Context for Skin Sarcoidosis

Organs/tissues related to Skin Sarcoidosis:

MalaCards : Skin, Lung, T Cells, Bone Marrow, Colon, Thyroid, Eye

Publications for Skin Sarcoidosis

Articles related to Skin Sarcoidosis:

(show top 50) (show all 757)
# Title Authors PMID Year
1
Utility of angiotensin-converting enzyme and serum calcium levels in cutaneous sarcoidosis. 62
36468818 2022
2
Superimposed mosaicism in cutaneous sarcoidosis: A hypothesis. 62
36448706 2022
3
Colon adenocarcinoma associated with intestinal sarcoidosis. 62
36353951 2022
4
Permanent Makeup Procedure Heralds the Development of Systemic Sarcoidosis. 62
36465789 2022
5
Intense pulsed light treatment for inflammatory skin diseases: a review. 62
35913536 2022
6
Cutaneous sarcoid-like reaction in a patient treated with target therapy for metastatic melanoma: the hue is the clue. 62
35871488 2022
7
Photodynamic therapy for the local control of refractory cutaneous sarcoidosis of the head: case report and review of the literature. 62
35436573 2022
8
Methotrexate for Cutaneous Sarcoidosis: A Dermatology-Based Case Series of 23 Patients. 62
35603863 2022
9
Cutaneous sarcoidosis mimicking pigmented purpuric dermatosis. 62
36070081 2022
10
Unusual case of cerebral embolism after initiation of selexipag for sarcoidosis-related pulmonary hypertension: a case report. 62
35755104 2022
11
A Rare Case of Subcutaneous Sarcoidosis in Patient With Psoriatic Arthritis. 62
35914788 2022
12
The Evolving Landscape of Cutaneous Sarcoidosis: Pathogenic Insight, Clinical Challenges, and New Frontiers in Therapy. 62
35583850 2022
13
Sarcoidosis and sarcoidal foreign body reaction after permanent eye makeup application: Analysis by immunohistochemistry with commercially available antibodies specific to Cutibacterium acnes and Mycobacteria. 62
35261067 2022
14
Cutaneous Sarcoidosis in Corona Virus Disease 19 Patient: A Red Herring or Sign of Recovery? 62
36262573 2022
15
[Sarcoidosis in head and neck area - a diagnostic challenge using the example of skin manifestations]. 62
34763353 2022
16
Cutaneous sarcoidosis: Lupus pernio and more. 62
35274876 2022
17
Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis. 62
35668129 2022
18
Increased risk of systemic and cardiac sarcoidosis in Black patients with cutaneous sarcoidosis. 62
33940102 2022
19
Systemic evaluation of cutaneous sarcoidosis: 15-year dermatology experience at University Hospital Limerick. 62
35020955 2022
20
Erythematous brownish plaques with an annular configuration. 62
35199376 2022
21
Annular elastolytic giant cell granuloma mimicking cutaneous sarcoidosis. 62
35425606 2022
22
Ichthyosiform sarcoidosis: Report of a case and comprehensive review of the literature. 62
33929723 2022
23
Unusual Case of Scalp Sarcoidosis with Alopecia: An Only Manifestation of Cutaneous Sarcoidosis without Systemic Involvement. 62
35450309 2022
24
Generalized ulcerative cutaneous sarcoidosis: an unusual presentation of the disease. 62
34363626 2022
25
[Sarcoid Granulomas Over Scars: Beyond Sarcoidosis]. 62
34871541 2022
26
Scar Sarcoidosis: A Retrospective Investigation into Its Peculiar Clinicopathologic Presentation. 62
35221592 2022
27
This month in JAAD Case Reports: January 2022. Targeting the Janus kinase-signal transducer and activator of transcription pathway in cutaneous sarcoidosis. 62
34757146 2022
28
Cutaneous sarcoidosis in eyebrows cosmetically pigmented with microblading method: A case report and review of the literature. 62
35991955 2022
29
Eyebrow tattoo-associated sarcoidosis: A case report. 62
36465914 2022
30
Atypical Protean Manifestations of Cutaneous Sarcoidosis. 62
35656240 2022
31
Sarcoidosis - a multisystem disease. 62
35072393 2022
32
Erythema nodosum-like sarcoid lesion: a specific skin manifestation occasionally seen in Japanese sarcoidosis patients. 62
35494169 2022
33
Evaluation of clinical and laboratory characteristics of patients with cutaneous sarcoidosis: A single-center retrospective cohort study. 62
36300194 2022
34
The Immunogenetics of Granulomatous Diseases. 62
35286702 2022
35
Cutaneous sarcoidosis of the scalp unmasking systemic involvement: A case report. 62
34659515 2021
36
Cutaneous sarcoidosis due to immune-checkpoint inhibition and exacerbated by a novel BRAF dimerization inhibitor. 62
35663773 2021
37
Cutaneous sarcoidosis with aggregated comedones in a young woman possibly associated with cosmetic laser treatment. 62
34514631 2021
38
Cutaneous Sarcoidosis of a 53-Year-Old Female: A Case Report. 62
34909312 2021
39
Ultrasonographic Patterns of Cutaneous Sarcoidosis. 62
33459396 2021
40
Cutaneous Sarcoid-Like Reaction on Tattooed Skin after Recovery from Coronavirus Disease 2019. 62
34980954 2021
41
[Low-dose, long-term fumaric acid esters in recalcitrant cutaneous sarcoidosis : Report of two cases]. 62
33598739 2021
42
Cutaneous sarcoidosis after application of secukinumab in a patient with plaque psoriasis. 62
34254698 2021
43
Treatment of cutaneous sarcoidosis with tofacitinib: A case report and review of evidence for Janus kinase inhibition in sarcoidosis. 62
34522749 2021
44
Ulcerative cutaneous sarcoidosis successfully treated with infliximab. 62
33728543 2021
45
Practice gaps in the evaluation of systemic involvement in patients with cutaneous sarcoidosis presenting to a dermatologist: A retrospective review of 48 patients. 62
33096130 2021
46
Dermoscopy in cutaneous sarcoidosis. 62
34755986 2021
47
Reflectance confocal microscopy of cutaneous sarcoidosis. 62
34532889 2021
48
Skin Sarcoidosis on Both Vitiligo and Tattoos in the Same Patient: Report of an Exceptional Case and Pathogenetic Hypotheses of Intriguing Associations. 62
35068521 2021
49
Multifocal Cutaneous Sarcoidosis Presenting as Lid Ectropion. 62
34667775 2021
50
Systemic Associations of Sarcoid Uveitis: Correlation With Uveitis Phenotype and Ethnicity. 62
33737030 2021

Variations for Skin Sarcoidosis

Expression for Skin Sarcoidosis

Search GEO for disease gene expression data for Skin Sarcoidosis.

Pathways for Skin Sarcoidosis

Pathways related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 CCR6 CD4 CD8A CTLA4 IFNA1 IFNG
2
Show member pathways
13.74 TNF JAK1 IL6 IL2 IL17A CD4
3
Show member pathways
13.58 TNF IL6 IL2 IL17A IFNG IFNA1
4
Show member pathways
13.49 TNF JAK1 IL6 IL2 IL17A IFNG
5
Show member pathways
13.37 TNF JAK1 IL6 IL2 IL17A CD4
6
Show member pathways
13.27 TNF JAK1 IL6 IL2 IL17A IFNG
7
Show member pathways
13.26 TNF IL6 IL2 IL17A CD4 CCR6
8
Show member pathways
12.82 TNF JAK1 IL6 IL2 IFNA1
9
Show member pathways
12.61 TNF JAK1 IL6 IL2 IL17A IFNG
10
Show member pathways
12.55 TNF JAK1 IL6 IL2 IL17A IFNG
11 12.44 TNF JAK1 IL2 IL17A IFNG IFNA1
12
Show member pathways
12.4 TNF JAK1 IL6 IFNG
13
Show member pathways
12.31 TNF JAK1 IL6 IFNG
14
Show member pathways
12.28 TNF JAK1 IL6 IL17A
15 12.2 TNF JAK1 IL6 IFNG
16
Show member pathways
12.13 JAK1 IL2 CD4
17 12.11 TNF JAK1 IL6 IFNG
18 12.01 TNF IL6 IL2 IFNG
19 12 TNF IL6 IL2 IFNG CD8A CD4
20
Show member pathways
11.99 IL2 IFNG CD8A CD4
21
Show member pathways
11.98 JAK1 IL2 IFNG
22 11.97 TNF JAK1 IL6 IL17A
23
Show member pathways
11.95 TNF JAK1 IFNG
24 11.89 JAK1 IL6 IFNG IFNA1
25 11.89 TNF IL2 IL17A IFNG CTLA4
26
Show member pathways
11.88 TNF IL2 IL17A IFNG CTLA4 CD8A
27
Show member pathways
11.87 CD4 IFNG IL17A IL6 JAK1
28
Show member pathways
11.86 JAK1 IL6 IL17A
29 11.77 IFNG IL2 IL6
30
Show member pathways
11.77 CD4 CD8A IL6
31 11.77 IFNG IL2 IL6 TNF
32 11.77 JAK1 IL6 IL2 IFNG CD4
33
Show member pathways
11.74 TNF IL2 IFNG CTLA4
34 11.72 IL6 IL2 IFNG
35
Show member pathways
11.71 TNF IL6 IL2 IFNG
36 11.71 CD4 CD8A IFNG IL2 IL6 TNF
37
Show member pathways
11.68 TNF IL6 IL2 IFNG
38 11.67 TNF JAK1 IL6
39 11.62 JAK1 IL6 IL2 IFNG
40 11.58 TNF IL6 IFNG
41 11.57 TNF IL2 IFNG CD4
42 11.57 JAK1 IL6 IL2 IL17A IFNG CD4
43 11.54 TNF JAK1 IL6
44 11.53 JAK1 IL2 IFNG CD4
45 11.51 IFNG IL6 TNF
46
Show member pathways
11.5 TNF JAK1 IL6 IL2 IL17A IFNG
47
Show member pathways
11.41 TNF IL2 IFNG
48 11.39 TNF JAK1 IL6
49 11.35 TNF IL6 IL17A IFNG
50 11.29 TNF IL6 IL2 IFNG CD4

GO Terms for Skin Sarcoidosis

Cellular components related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.91 TNF CTLA4 CD8A CD4 CCR6 ACE
2 plasma membrane GO:0005887 9.91 TNF CTLA4 CD8A CD4 CCR6 ACE
3 external side of plasma membrane GO:0009897 9.47 TNF IL17A CTLA4 CD8A CD4 CCR6

Biological processes related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of inflammatory response GO:0050729 10.1 TNF IL2 IFNG ACE
2 positive regulation of interleukin-6 production GO:0032755 10.03 TNF IL6 IL17A IFNG
3 regulation of insulin secretion GO:0050796 10.02 TNF IL6 IFNG
4 positive regulation of chemokine production GO:0032722 10.01 TNF IL6 IFNG
5 adaptive immune response GO:0002250 10 CD4 CD8A CTLA4 IFNA1 IFNG IL17A
6 immune system process GO:0002376 9.97 IL2 IL17A CTLA4 CD8A CD4
7 cellular response to virus GO:0098586 9.97 JAK1 IL6 IFNG IFNA1
8 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.95 TNF IL6 IL17A
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 TNF IL6 IL2 IFNG
10 negative regulation of lipid storage GO:0010888 9.89 TNF IL6
11 neutrophil mediated immunity GO:0002446 9.88 IL6 ACE
12 positive regulation of osteoclast differentiation GO:0045672 9.88 IFNG IL17A TNF
13 positive regulation of interleukin-23 production GO:0032747 9.87 IL17A IFNG
14 vascular endothelial growth factor production GO:0010573 9.86 TNF IL6
15 positive regulation of interleukin-1 beta production GO:0032731 9.86 TNF IL6 IL17A IFNG
16 positive regulation of nitrogen compound metabolic process GO:0051173 9.83 IFNG TNF
17 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.81 IFNG TNF
18 positive regulation of vitamin D biosynthetic process GO:0060557 9.76 TNF IFNG
19 humoral immune response GO:0006959 9.65 TNF IL6 IFNG IFNA1 CCR6
20 immune response GO:0006955 9.5 TNF IL6 IL2 IL17A IFNG CTLA4

Molecular functions related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.4 TNF IL6 IL2 IL17A IFNG IFNA1

Sources for Skin Sarcoidosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....