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MCID: SKN006
MIFTS: 40

Skin Sarcoidosis

Categories: Immune diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Skin Sarcoidosis

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MalaCards integrated aliases for Skin Sarcoidosis:

Name: Skin Sarcoidosis 12 15 17
Cutaneous Sarcoidosis 12 74
Cutaneous Sarcoid 12

Classifications:

MalaCards categories:
Anatomical: Immune diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:13402
NCIt 51 C34996
SNOMED-CT 69 55941000
ICD10 34 D86.3
UMLS 74 C0036203
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Summaries for Skin Sarcoidosis

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MalaCards based summary : Skin Sarcoidosis, also known as cutaneous sarcoidosis, is related to vasculitis and sarcoidosis 1. An important gene associated with Skin Sarcoidosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are NF-kappaB Signaling and Amyotrophic lateral sclerosis (ALS). The drugs Apremilast and Endorphins have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and t cells, and related phenotype is liver/biliary system.

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Related Diseases for Skin Sarcoidosis

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Diseases related to Skin Sarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 vasculitis 29.4 TNF TNFRSF1B
2 sarcoidosis 1 29.4 ACE TNF TNFRSF1B
3 blau syndrome 11.2
4 bladder neck obstruction 10.2 ACE TNFRSF1B
5 uveoparotid fever 10.2 ACE TNF
6 subacute cutaneous lupus erythematosus 10.2 ACE TNF
7 posterior urethral valves 10.2 ACE TNF
8 hepatitis 10.2
9 ischemic heart disease 10.2 ACE TNF
10 juvenile ankylosing spondylitis 10.1 TNF TNFRSF1B
11 spondylitis 10.1 TNF TNFRSF1B
12 chronic gonococcal salpingitis 10.1 TNF TNFRSF1B
13 scleral disease 10.1 TNF TNFRSF1B
14 pustulosis of palm and sole 10.1 TNF TNFRSF1B
15 peroneal neuropathy 10.1 TNF TNFRSF1B
16 extrinsic cardiomyopathy 10.1 ACE TNF
17 periodic fever, familial, autosomal dominant 10.1 TNF TNFRSF1B
18 rheumatic heart disease 10.1 ACE TNF
19 hepatitis c 10.1
20 acute salpingitis 10.1 TNF TNFRSF1B
21 post-transplant lymphoproliferative disease 10.1 TNF TNFRSF1B
22 pyelonephritis 10.1 ACE TNF
23 chronic salpingitis 10.1 TNF TNFRSF1B
24 limb ischemia 10.1 ACE TNF
25 exanthem 10.1 TNF TNFRSF1B
26 panuveitis 10.1 TNF TNFRSF1B
27 silicosis 10.1 ACE TNF
28 cogan syndrome 10.1 TNF TNFRSF1B
29 carotid stenosis 10.1 ACE TNF
30 palindromic rheumatism 10.1 TNF TNFRSF1B
31 adult respiratory distress syndrome 10.1 ACE TNF
32 pulmonary sarcoidosis 10.1 ACE TNF
33 uveal disease 10.1 TNF TNFRSF1B
34 pulmonary edema 10.1 ACE TNF
35 guillain-barre syndrome 10.1 TNF TNFRSF1B
36 sleep apnea 10.1 ACE TNF
37 rasmussen encephalitis 10.1 ADK TNF
38 end stage renal failure 10.1 ACE TNF
39 spondyloarthropathy 1 10.1 TNF TNFRSF1B
40 primary bacterial infectious disease 10.1 TNF TNFRSF1B
41 vascular dementia 10.1 ACE TNF
42 bone inflammation disease 10.1 TNF TNFRSF1B
43 arteries, anomalies of 10.0 ACE TNF
44 autoimmune disease of peripheral nervous system 10.0 CD1E TNF
45 glucose metabolism disease 10.0 ACE TNF
46 juvenile rheumatoid arthritis 10.0 TNF TNFRSF1B
47 membranous nephropathy 10.0 ACE TNF
48 chagas disease 10.0 ACE TNF
49 melanoma 10.0
50 urinary system disease 10.0 ACE TNF

Graphical network of the top 20 diseases related to Skin Sarcoidosis:



Diseases related to Skin Sarcoidosis
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Symptoms & Phenotypes for Skin Sarcoidosis

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MGI Mouse Phenotypes related to Skin Sarcoidosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.92 ACE ADK TNF TNFRSF1B
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Drugs & Therapeutics for Skin Sarcoidosis

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Drugs for Skin Sarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apremilast Approved, Investigational Phase 2, Phase 3 608141-41-9 11561674
2 Endorphins Phase 2, Phase 3
3 Hormones Phase 2, Phase 3
4 beta-endorphin Phase 2, Phase 3
5 Neurotransmitter Agents Phase 2, Phase 3
6 Hormone Antagonists Phase 2, Phase 3
7 Melanocyte-Stimulating Hormones Phase 2, Phase 3
8 Adrenocorticotropic Hormone Phase 2, Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
10 Analgesics, Non-Narcotic Phase 2, Phase 3
11 Antirheumatic Agents Phase 2, Phase 3
12 Analgesics Phase 2, Phase 3
13 Immunologic Factors Phase 2, Phase 3,Phase 3
14 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
15 Immunosuppressive Agents Phase 2, Phase 3,Phase 3
16 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
17 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3,Phase 1
18 Anti-Inflammatory Agents Phase 2, Phase 3
19 Angiogenesis Modulating Agents Phase 2, Phase 3,Phase 3
20 Peripheral Nervous System Agents Phase 2, Phase 3
21 Angiogenesis Inhibitors Phase 2, Phase 3,Phase 3
22
Adalimumab Approved Phase 2 331731-18-1 16219006
23
Ethambutol Approved Phase 1, Phase 2 74-55-5 3279 14052
24
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583
25
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
26
Rifampicin Approved Phase 1, Phase 2 13292-46-1 5381226 5458213
27
Azithromycin Approved Phase 1, Phase 2 83905-01-5 55185 447043
28
Ustekinumab Approved, Investigational Phase 2 815610-63-0
29 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
30 Cytochrome P-450 CYP1A2 Inhibitors Phase 1, Phase 2
31 Renal Agents Phase 1, Phase 2
32 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
33 Topoisomerase Inhibitors Phase 1, Phase 2
34 Antibiotics, Antitubercular Phase 1, Phase 2
35 Anti-Infective Agents, Urinary Phase 1, Phase 2
36 Cytochrome P-450 CYP3A Inducers Phase 1, Phase 2
37 Antitubercular Agents Phase 1, Phase 2
38 Antibodies Phase 2
39 Dermatologic Agents Phase 2
40 Antibodies, Monoclonal Phase 2
41 Immunoglobulins Phase 2
42
Maraviroc Approved, Investigational Not Applicable 376348-65-1 3002977
43 Antiviral Agents Not Applicable
44 Anesthetics Not Applicable
45 Anti-HIV Agents Not Applicable
46 Pharmaceutical Solutions Not Applicable
47 Anti-Retroviral Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ACTHAR Gel for Cutaneous Sarcoidosis: An Open Label Trial Unknown status NCT02348905 Phase 2, Phase 3 ACTHAR Gel 40 units twice weekly;ACTHAR Gel 80 units twice weekly.
2 The Efficacy and Safety of CC-10004 in Chronic Cutaneous Sarcoidosis Completed NCT00794274 Phase 2, Phase 3 CC-100004
3 SARCOTHAL. Thalidomide in Skin Sarcoidosis Completed NCT00305552 Phase 3 THALIDOMIDE
4 A Study of Adalimumab to Treat Sarcoidosis of the Skin Completed NCT00274352 Phase 2 adalimumab
5 Trial of Antimycobacterial Therapy in Sarcoidosis Completed NCT01074554 Phase 1, Phase 2 Antibiotic Regimen;Placebo Regimen
6 A Study to Evaluate the Safety and Effectiveness of Ustekinumab or Golimumab Administered Subcutaneously (SC) in Patients With Sarcoidosis Completed NCT00955279 Phase 2 Placebo;Golimumab;Ustekinumab
7 A Phase 2 Study With CC-220 in Skin Sarcoidosis Withdrawn NCT02192489 Phase 2 CC-220 0.3 mg Daily;CC-220 0.6mg Daily;Placebo
8 Efficacy Study of Humira in the Treatment of Cutaneous Sarcoidosis Withdrawn NCT00731757 Phase 2 Humira
9 Study to Determine the Efficacy of Adalimumab in the Treatment of Cutaneous Sarcoidosis Withdrawn NCT00690911 Phase 2 adalimumab
10 Impact of Chemokine Receptor 5 (CCR5) Inhibition on Sarcoidosis Immunophenotypes Terminated NCT02134717 Not Applicable all subjects will receive maraviroc 300mg orally twice a day for 6 weeks

Search NIH Clinical Center for Skin Sarcoidosis

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Genetic Tests for Skin Sarcoidosis

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Anatomical Context for Skin Sarcoidosis

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MalaCards organs/tissues related to Skin Sarcoidosis:

42
Skin, Thyroid, T Cells
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Publications for Skin Sarcoidosis

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Articles related to Skin Sarcoidosis:

(show top 50) (show all 235)
# Title Authors Year
1
Management of skin sarcoidosis with minocycline monotherapy. ( 30911395 )
2019
2
Heerfordt syndrome developing in a patient with cutaneous sarcoidosis. ( 30623412 )
2019
3
In-vivo assessment of a case of cutaneous sarcoidosis using reflectance confocal microscopy. ( 30726472 )
2019
4
Biologic Therapy in the Treatment of Cutaneous Sarcoidosis: A Literature Review. ( 30895525 )
2019
5
Physicochemical characterization of inorganic deposits associated with granulomas in cutaneous sarcoidosis. ( 29972866 )
2019
6
Cutaneous sarcoidosis after Hodgkin lymphoma. ( 30411336 )
2018
7
Polymorphous Cutaneous Sarcoidosis Associated with Peripheral Vascular Disease and its Dermatoscopic Findings. ( 30050815 )
2018
8
Cutaneous sarcoidosis in a patient with rheumatoid arthritis receiving tocilizumab. ( 29500868 )
2018
9
Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis. ( 30586518 )
2018
10
Dermoscopy of a single plaque on the face: an uncommon presentation of cutaneous sarcoidosis. ( 30116658 )
2018
11
Concurrent Diagnoses of Cutaneous Sarcoidosis and Recurrent Metastatic Breast Cancer: More than a Coincidental Occurrence? ( 30254768 )
2018
12
Micropapular Cutaneous Sarcoidosis Reviewed. ( 30278434 )
2018
13
The natural history of cutaneous sarcoidosis. Clinical spectrum and histological analysis of 40 cases. ( 30306543 )
2018
14
Exploring the dynamic changes between pulmonary and cutaneous sarcoidosis based on gene expression. ( 30403187 )
2018
15
Oral Fumaderm® to treat cutaneous sarcoidosis. ( 29756252 )
2018
16
Cutaneous sarcoidosis: a new subset in the spectrum of paraneoplastic dermatoses. ( 29779211 )
2018
17
Light and Laser Modalities in the Treatment of Cutaneous Sarcoidosis: A Systematic Review. ( 29242948 )
2018
18
Cutaneous sarcoidosis and secondary open-angle glaucoma in a patient: case report and literature review. ( 29186261 )
2017
19
Annular lesions of cutaneous sarcoidosis with granulomatous vasculitis. ( 28116823 )
2017
20
Annular cutaneous sarcoidosis with systemic involvement. ( 29417028 )
2017
21
Cutaneous sarcoidosis: A retrospective case series and a hospital-based case-control study in Taiwan. ( 28984765 )
2017
22
Unconventional use of fractional ablative CO2 laser in facial cutaneous sarcoïdosis. ( 29082596 )
2017
23
Recalcitrant Diffuse Cutaneous Sarcoidosis With Perianal Involvement Responding to Adalimumab. ( 29240869 )
2017
24
Quantification of granuloma volume and response to treatment in cutaneous sarcoidosis using 3-dimensional high-frequency ultrasound scan. ( 29264382 )
2017
25
Nivolumab-related cutaneous sarcoidosis in a patient with lung adenocarcinoma. ( 28443311 )
2017
26
Efficacy and Tolerance of Anti-Tumor Necrosis Factor α Agents in Cutaneous Sarcoidosis: A French Study of 46 Cases. ( 28564695 )
2017
27
Cutaneous sarcoidosis. ( 28598873 )
2017
28
Koebnerization phenomenon after broadband light therapy in a patient with cutaneous sarcoidosis. ( 28752117 )
2017
29
An Adolescent with Extensive Cutaneous Sarcoidosis without Lung Involvement. ( 28213883 )
2017
30
High frequency ultrasound: a novel instrument to quantify granuloma burden in cutaneous sarcoidosis. ( 29628755 )
2017
31
A case of hyaluronic acid injections triggering cutaneous sarcoidosis at previously treated sites. ( 27357733 )
2017
32
Plantar subcutaneous sarcoidosisA -A a rare form of skin sarcoidosis: unusual plantar aponeurosis location of sarcoidosis as primary manifestation of asymptomatic systemic disease. ( 26865475 )
2016
33
Development of exclusively cutaneous sarcoidosis in patient with rheumatoid arthritis during treatment with etanercept. ( 27992009 )
2016
34
Epidemiology of cutaneous sarcoidosis, 1976-2013: a population-based study from Olmsted County, Minnesota. ( 27324138 )
2016
35
Cutaneous sarcoidosis at insulin injection sites. ( 26783329 )
2016
36
Infliximab for chronic cutaneous sarcoidosis: a subset analysis from a double-blind randomized clinical trial. ( 26847095 )
2016
37
Erythematous patches and pretibial ulcers: an uncommon presentation of cutaneous sarcoidosis. ( 26972195 )
2016
38
Cutaneous sarcoidosis with zosteriform distribution and pulmonary involvement. ( 27176087 )
2016
39
Cutaneous sarcoidosis in a melanoma patient under Ipilimumab therapy. ( 27357143 )
2016
40
Cutaneous Sarcoidosis Misdiagnosed as Leprosy. Report of Two Cases and Review of Literature. ( 30207442 )
2016
41
Isolated Cutaneous Sarcoidosis. ( 26552871 )
2016
42
Response to letter "evaluation of cardiac involvement in caucasian patients with skin sarcoidosis". ( 25581211 )
2015
43
Evaluation of cardiac involvement in caucasian patients with skin sarcoidosis. ( 25598240 )
2015
44
Takayasu arteritis and ulcerative cutaneous sarcoidosis. ( 25948351 )
2015
45
Resident Rounds: Part III--Cutaneous Sarcoidosis in a Blepharoplasty Scar. ( 26875206 )
2015
46
Cardiac involvement in cutaneous sarcoidosis: case reports and review of the literature. ( 26376041 )
2015
47
Cutaneous sarcoidosis in a patient with severe asthma treated with omalizumab. ( 26401982 )
2015
48
"Apple Jelly" Sign: Diascopy in Cutaneous Sarcoidosis. ( 26421796 )
2015
49
Cutaneous Sarcoidosis. ( 26593142 )
2015
50
Epidemiological, Clinical, and Paraclinic Aspect of Cutaneous Sarcoidosis in Black Africans. ( 26633968 )
2015
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Variations for Skin Sarcoidosis

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Expression for Skin Sarcoidosis

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Search GEO for disease gene expression data for Skin Sarcoidosis.
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Pathways for Skin Sarcoidosis

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Pathways related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.65 CD83 TNF TNFRSF1B
2
Amyotrophic lateral sclerosis (ALS) 38 1
Show member pathways
 11.57 TNF TNFRSF1B
3
Interleukin-4 and 13 signaling 67
11.55 TNF TNFRSF1B
4
TNF signaling pathway 38
11.52 TNF TNFRSF1B
5
Hematopoietic cell lineage 38
11.44 CD1E TNF
6
Dendritic Cells Developmental Lineage Pathway 66
11.3 CD83 TNF
7
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 23
Show member pathways
 11.27 TNF TNFRSF1B
8
Adipocytokine signaling pathway 38
11.21 TNF TNFRSF1B
9
Transcription_NF-kB signaling pathway 23
11.05 TNF TNFRSF1B
10
Cellular Transformation by HTLV1 65
Show member pathways
 10.96 TNF TNFRSF1B
11
Interleukin-10 signaling 67
10.85 TNF TNFRSF1B
12
14-3-3 and Regulation of BAD Activity 65
10.13 TNF TNFRSF1B
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GO Terms for Skin Sarcoidosis

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Cellular components related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 ACE CD83 TNF

Biological processes related to Skin Sarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.54 CD1E TNF TNFRSF1B
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.32 TNF TNFRSF1B
3 humoral immune response GO:0006959 9.26 CD83 TNF
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.16 TNF TNFRSF1B
5 extrinsic apoptotic signaling pathway GO:0097191 8.96 TNF TNFRSF1B
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.62 TNF TNFRSF1B
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Sources for Skin Sarcoidosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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