MCID: SKN021
MIFTS: 33

Skin Sarcoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Skin Sarcoma

MalaCards integrated aliases for Skin Sarcoma:

Name: Skin Sarcoma 12 15 73
Cutaneous Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2687
NCIt 50 C5585
UMLS 73 C0856900

Summaries for Skin Sarcoma

Disease Ontology : 12 A sarcoma that is located in the skin.

MalaCards based summary : Skin Sarcoma, also known as cutaneous sarcoma, is related to dermatofibrosarcoma protuberans and ring chromosome 4. An important gene associated with Skin Sarcoma is PDGFB (Platelet Derived Growth Factor Subunit B), and among its related pathways/superpathways are Cushing syndrome and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Gastrointestinal Agents and Cathartics have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Skin Sarcoma

Diseases related to Skin Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 dermatofibrosarcoma protuberans 29.8 CD34 COL1A1 PDGFB
2 ring chromosome 4 10.3 COL1A1 PDGFB
3 bednar tumor 10.3 COL1A1 PDGFB
4 malignant spindle cell melanoma 10.2 MITF NGFR
5 dermis tumor 10.2 CD163 COL1A1 PDGFB
6 cauda equina neoplasm 10.2 EWSR1 SYP
7 gastric leiomyoma 10.2 CALD1 FH
8 fibrous histiocytoma 10.2 CD163 EWSR1 MITF
9 histiocytoma 10.2 CD163 EWSR1 MITF
10 extraosseous chondrosarcoma 10.2 EWSR1 SYP
11 lung combined type small cell carcinoma 10.2 CALD1 SYP
12 myxoid chondrosarcoma 10.2 CDKN2B EWSR1 MAPT
13 olfactory neuroblastoma 10.2 EWSR1 NGFR SYP
14 oligodendroglioma 10.2 CDKN2B PDGFB SYP
15 plexiform schwannoma 10.1 CD34 NGFR
16 bone epithelioid hemangioma 10.1 CD34 EWSR1
17 vulvar sarcoma 10.1 CD34 EWSR1
18 central nervous system sarcoma 10.1 CD163 CD68
19 pigmented basal cell carcinoma 10.1 CLEC2A FOXO4 MITF
20 adult fibrosarcoma 10.1 CD34 COL1A1 PDGFB
21 lymphoplasmacyte-rich meningioma 10.1 CD163 CD68
22 breast myofibroblastoma 10.1 CALD1 CD34
23 intravascular fasciitis 10.1 CALD1 CD34
24 leiomyoma cutis 10.1 CALD1 CLEC2A FH
25 deep leiomyoma 10.1 CALD1 CD34
26 glomangiomyoma 10.1 CALD1 CD34
27 breast leiomyosarcoma 10.1 CALD1 CD34
28 balloon cell malignant melanoma 10.1 CD68 FOXO4
29 scrotal carcinoma 10.1 CD68 CDKN2B
30 conventional angiosarcoma 10.1 CD34 SYP
31 inflamed seborrheic keratosis 10.1 CD68 CLEC2A
32 chondrosarcoma, extraskeletal myxoid 10.1 CREB3L2 EWSR1 SYP
33 cell type benign neoplasm 10.1 CD34 FH SYP
34 meninges sarcoma 10.1 CD34 CREB3L2
35 peritoneal benign neoplasm 10.1 CALD1 CD34
36 neurofibroma 10.1 CD34 MITF SYP
37 sclerosing liposarcoma 10.1 CD34 CREB3L2
38 liver sarcoma 10.1 CD68 PDGFB
39 hordeolum 10.0 ACRV1 CD34
40 inflammatory mfh 10.0 CALD1 CD68
41 petroclival meningioma 10.0 CD163 CD68
42 breast angiosarcoma 10.0 CD34 MITF
43 venous hemangioma 10.0 CD34 SYP
44 inflammatory leiomyosarcoma 10.0 CALD1 CD68
45 retina lymphoma 10.0 CD34 CD68
46 diffuse peritoneal leiomyomatosis 10.0 CALD1 CD34
47 postencephalitic parkinson disease 10.0 MAPT SYP
48 deep angioma 10.0 CD34 CREB3L2
49 extracutaneous mastocytoma 10.0 CD34 CD68
50 mesenchymal cell neoplasm 10.0 CALD1 CD34 EWSR1

Graphical network of the top 20 diseases related to Skin Sarcoma:



Diseases related to Skin Sarcoma

Symptoms & Phenotypes for Skin Sarcoma

GenomeRNAi Phenotypes related to Skin Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.13 FOXO4
2 Decreased viability GR00221-A-2 10.13 FOXO4 PDGFB
3 Decreased viability GR00221-A-3 10.13 PDGFB
4 Decreased viability GR00221-A-4 10.13 FOXO4
5 Decreased viability GR00240-S-1 10.13 PDGFB
6 Decreased viability GR00381-A-1 10.13 CD163 CREB3L2
7 Decreased viability GR00381-A-2 10.13 CD163
8 Decreased viability GR00381-A-3 10.13 CD163
9 Decreased viability GR00402-S-2 10.13 ACRV1 CALD1 CD163 CD209 CD34 CD68
10 no effect GR00402-S-1 9.62 ACRV1 CALD1 CD163 CD209 CD34 CD68

MGI Mouse Phenotypes related to Skin Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 CD163 CD34 CDKN2B COL1A1 EZH2 FH
2 hematopoietic system MP:0005397 10.07 CD163 CD34 CD68 CDKN2B COL1A1 EZH2
3 immune system MP:0005387 9.96 CD163 CD34 CD68 CDKN2B COL1A1 EZH2
4 integument MP:0010771 9.76 CD34 CDKN2B COL1A1 EZH2 MAPT MITF
5 neoplasm MP:0002006 9.43 CD34 CDKN2B COL1A1 EZH2 FOXO4 MAPT
6 no phenotypic analysis MP:0003012 9.17 CD68 CDKN2B COL1A1 EZH2 MAPT MITF

Drugs & Therapeutics for Skin Sarcoma

Drugs for Skin Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Gastrointestinal Agents Phase 2
2 Cathartics Phase 2
3 Antiviral Agents Phase 2
4 Carboxymethylcellulose Sodium Phase 2
5 interferons Phase 2
6 Poly ICLC Phase 2
7 Anti-Infective Agents Phase 2
8 Laxatives Phase 2
9 Poly I-C Phase 2
10 Vaccines Phase 2
11 Immunologic Factors Phase 2
12 Interferon Inducers Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Solid Tumors With Intratumoral Hiltonol® (Poly-ICLC) Terminated NCT01984892 Phase 2 Poly-ICLC
2 Infrared Thermography in Finding Skin Lesions in Patients With Kaposi's Sarcoma Unknown status NCT00265902 Not Applicable

Search NIH Clinical Center for Skin Sarcoma

Genetic Tests for Skin Sarcoma

Anatomical Context for Skin Sarcoma

MalaCards organs/tissues related to Skin Sarcoma:

41
Skin, Lung, Liver, Bone, Spleen, Retina

The Foundational Model of Anatomy Ontology organs/tissues related to Skin Sarcoma:

19
The Skin

Publications for Skin Sarcoma

Articles related to Skin Sarcoma:

# Title Authors Year
1
Effects of synthetic bis-beta-chloroethylamine estrogen derivatives on proliferation of skin sarcoma cells. ( 11022259 )
2000
2
Comparison of dose distribution by means of bolus versus water bath phantom techniques in treatment of cutaneous sarcoma of an extremity. ( 2127359 )
1990
3
Oxygen consumption and histological studies of mouse skin during the induction of cutaneous sarcoma with methylcholanthrene. ( 4989030 )
1970
4
Multiple carcinomatous growths and skin sarcoma in a patient with chronic roentgen-ray dermatosis. ( 13927643 )
1963
5
Cutaneous sarcoma-like lesions of the horse caused by the agent of bovine papilloma. ( 14854020 )
1951

Variations for Skin Sarcoma

Expression for Skin Sarcoma

Search GEO for disease gene expression data for Skin Sarcoma.

Pathways for Skin Sarcoma

GO Terms for Skin Sarcoma

Biological processes related to Skin Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.55 COL1A1 CREB3L2 FOXO4 MITF PDGFB
2 positive regulation of smooth muscle cell migration GO:0014911 9.26 FOXO4 PDGFB
3 negative regulation of gene expression GO:0010629 9.26 CD34 EZH2 MAPT PDGFB
4 paracrine signaling GO:0038001 8.62 CD34 PDGFB

Molecular functions related to Skin Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 COL1A1 EWSR1 FOXO4 MAPT PDGFB SYP
2 tropomyosin binding GO:0005523 8.96 CALD1 S100A6
3 platelet-derived growth factor binding GO:0048407 8.62 COL1A1 PDGFB

Sources for Skin Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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