MCID: SKN021
MIFTS: 30

Skin Sarcoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Skin Sarcoma

MalaCards integrated aliases for Skin Sarcoma:

Name: Skin Sarcoma 12 15 17 70
Cutaneous Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2687
NCIt 50 C5585
UMLS 70 C0856900

Summaries for Skin Sarcoma

Disease Ontology : 12 A sarcoma that is located in the skin.

MalaCards based summary : Skin Sarcoma, also known as cutaneous sarcoma, is related to malignant mesenchymoma and spindle cell sarcoma. An important gene associated with Skin Sarcoma is PDGFB (Platelet Derived Growth Factor Subunit B), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include skin, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Related Diseases for Skin Sarcoma

Diseases related to Skin Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
# Related Disease Score Top Affiliating Genes
1 malignant mesenchymoma 30.0 CD34 CALD1
2 spindle cell sarcoma 29.8 KIT CD34 CALD1
3 pleomorphic liposarcoma 29.4 KIT CALD1
4 dermatofibrosarcoma protuberans 29.2 PDGFB KIT COL1A1 CD34
5 cutaneous fibrous histiocytoma 29.1 PDGFB MLANA COL1A1 CD68 CD34
6 angiosarcoma 28.6 PECAM1 MLANA KIT CD68 CD34
7 skin carcinoma 28.5 PECAM1 MLANA KIT CD68 CD34
8 mesenchymal cell neoplasm 28.3 PECAM1 MLANA KIT CD68 CD34 CALD1
9 glomus tumor 10.3 CD34 CALD1
10 myofibroma 10.3 CD34 CALD1
11 ring chromosome 4 10.3 PDGFB COL1A1
12 ring chromosome 10.3 PDGFB COL1A1
13 breast myofibroblastoma 10.3 CD34 CALD1
14 pulmonary vein leiomyosarcoma 10.3 CD34 CALD1
15 bednar tumor 10.3 PDGFB COL1A1
16 glomangiomyoma 10.3 CD34 CALD1
17 peritoneal benign neoplasm 10.3 CD34 CALD1
18 adult fibrosarcoma 10.3 CD34 CALD1
19 cervical polyp 10.3 CD34 CALD1
20 testicular fibroma 10.3 CD34 CALD1
21 intravenous leiomyomatosis 10.3 CD34 CALD1
22 skin epithelioid hemangioma 10.3 PECAM1 CD34
23 aortic malignant tumor 10.3 PECAM1 CD34
24 prostate angiosarcoma 10.3 PECAM1 CD34
25 central nervous system angiosarcoma 10.3 PECAM1 CD34
26 central nervous system hemangioma 10.3 PECAM1 CD34
27 heart fibrosarcoma 10.3 PECAM1 CD34
28 ovarian angiosarcoma 10.2 PECAM1 CD34
29 conventional angiosarcoma 10.2 PECAM1 CD34
30 thyroid sarcoma 10.2 PECAM1 CD34
31 pediatric angiosarcoma 10.2 PECAM1 CD34
32 breast hemangioma 10.2 PECAM1 CD34
33 hemangioma of spleen 10.2 PECAM1 CD34
34 cervical adenosarcoma 10.2 CD34 CALD1
35 intramuscular hemangioma 10.2 PECAM1 CD34
36 liposarcoma of bone 10.2 PECAM1 CD34
37 colonic lymphangioma 10.2 PECAM1 CD34
38 hobnail hemangioma 10.2 PECAM1 CD34
39 erythema elevatum diutinum 10.2 PECAM1 CD34
40 kaposiform hemangioendothelioma 10.2 PECAM1 CD34
41 myxosarcoma 10.2 PECAM1 CALD1
42 capillary lymphangioma 10.2 PECAM1 CD34
43 ovarian endometrioid stromal sarcoma 10.2 PECAM1 CALD1
44 bacillary angiomatosis 10.2 PECAM1 CD34
45 thyroid angiosarcoma 10.2 PECAM1 CD34
46 angiokeratoma circumscriptum 10.2 PECAM1 CD34
47 histiocytoid hemangioma 10.2 PECAM1 CD34
48 ovarian melanoma 10.2 MLANA CALD1
49 penis sarcoma 10.2 MLANA CD34
50 sweat gland benign neoplasm 10.2 CD34 CALD1

Graphical network of the top 20 diseases related to Skin Sarcoma:



Diseases related to Skin Sarcoma

Symptoms & Phenotypes for Skin Sarcoma

GenomeRNAi Phenotypes related to Skin Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.23 KIT PDGFB
2 Decreased substrate adherent cell growth GR00193-A-2 9.23 KIT PDGFB SNRK
3 Decreased substrate adherent cell growth GR00193-A-3 9.23 PDGFB
4 Decreased substrate adherent cell growth GR00193-A-4 9.23 KIT PDGFB

MGI Mouse Phenotypes related to Skin Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.35 CD68 COL1A1 KIT MLANA PDGFB
2 pigmentation MP:0001186 8.92 COL1A1 KIT MLANA PDGFB

Drugs & Therapeutics for Skin Sarcoma

Search Clinical Trials , NIH Clinical Center for Skin Sarcoma

Genetic Tests for Skin Sarcoma

Anatomical Context for Skin Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Skin Sarcoma:

19
Skin

MalaCards organs/tissues related to Skin Sarcoma:

40
Skin

Publications for Skin Sarcoma

Articles related to Skin Sarcoma:

(show top 50) (show all 63)
# Title Authors PMID Year
1
[Case report: Epigastric dermatofibroma reconstruction by reverse abdominoplasty with umbilic transposition]. 61
33715869 2021
2
Ewing's Primary Cutaneous Sarcoma in a Pregnant Patient. 61
33160986 2020
3
Multidisciplinary surgical treatment approach for dermatofibrosarcoma protuberans: an update. 61
32770258 2020
4
[Dermatofibrosarcoma protuberans : clinico-pathological aspects and management]. 61
32239838 2020
5
Programmed cell death 1 protein and programmed death-ligand 1 inhibitors in the treatment of nonmelanoma skin cancer: A systematic review. 61
31163235 2020
6
Response to anti-PD1 immunotherapy in patients with metastatic cutaneous sarcoma: case reports and literature review. 61
32038880 2020
7
A synchronous presentation of malignant melanoma and dermatofibrosarcoma protuberans in a Nigerian female: A case report. 61
33207424 2020
8
Dermatofibrosarcoma Protuberans: The Current State of Multidisciplinary Management. 61
33160438 2020
9
S1 guidelines for dermatofibrosarcoma protuberans (DFSP) - update 2018. 61
31115967 2019
10
Current Update on the Molecular Biology of Cutaneous Sarcoma: Dermatofibrosarcoma Protuberans. 61
30874910 2019
11
Dermatofibrosarcoma protuberans (DFSP) arising from a keloid scar - A case report. 61
32158839 2018
12
Management of dermatofibrosarcoma protuberans of the face using lower trapezius musculocutaneous pedicle flap reconstruction: a case report. 61
29942467 2018
13
Recurrent Dermatofibrosarcoma Protuberans of Scalp in a Distant Location 10 Years after Primary Excision. 61
29606823 2018
14
A peer review process as part of the implementation of clinical pathways in radiation oncology: Does it improve compliance? 61
28284760 2017
15
Adaptive Immunity in Fibrosarcomatous Dermatofibrosarcoma Protuberans and Response to Imatinib Treatment. 61
27608549 2017
16
Hormone receptor expression in patients with dermatofibrosarcoma protuberans. 61
27542587 2016
17
Evolution of Dermatofibrosarcoma Protuberans to DFSP-Derived Fibrosarcoma: An Event Marked by Epithelial-Mesenchymal Transition-like Process and 22q Loss. 61
27256159 2016
18
Palisading and Verocay body-prominent dermatofibrosarcoma protuberans: A case report. 61
26725533 2016
19
Incidence and Survival of Primary Dermatofibrosarcoma Protuberans in the United States. 61
26730971 2016
20
Dermatofibrosarcoma Protuberans: Insights into a Rare Soft Tissue Tumor. 61
27195182 2016
21
Dermatofibrosarcoma protuberans: a case report and review of the literature. 61
27895450 2016
22
Electrochemotherapy of a Multirecurrent Dermatofibrosarcoma Protuberans of the Orbital Margin: A Case Report. 61
26504038 2015
23
CDKN2A/p16 Loss Implicates CDK4 as a Therapeutic Target in Imatinib-Resistant Dermatofibrosarcoma Protuberans. 61
25852058 2015
24
Multiple Histological Subtypes of Dermatofibrosarcoma Protuberans Occurring in the Same Tumor. 61
26076565 2015
25
Risk factors for radiotherapy incidents and impact of an online electronic reporting system. 61
25150636 2014
26
Dermatofibrosarcoma protuberans: clinical series, national Danish incidence data and suggested guidelines. 61
23837507 2014
27
Multidisciplinary approach to the management of dermatofibrosarcoma protuberans. 61
22387033 2012
28
Dermatofibrosarcoma protuberans. 61
22285046 2012
29
Sarcoma metastases to the skin: a clinicopathologic study of 65 patients. 61
21989966 2012
30
Advances in the systemic treatment of cutaneous sarcomas. 61
22484189 2012
31
Combined cutaneous sarcoma: pleomorphic liposarcoma and conventional osteosarcoma-the so-called malignant mesenchymoma. 61
23082265 2012
32
Management of chest wall reconstruction after resection for cancer: a retrospective study of 22 consecutive patients. 61
21407062 2011
33
Does the two-week rule pathway improve the diagnosis of soft tissue sarcoma? A retrospective review of referral patterns and outcomes over five years in a regional sarcoma centre. 61
20487596 2010
34
[Dermatofibrosarcoma protuberans]. 61
18936902 2008
35
[Dermatofibrosarcoma protuberans: surgical treatment using the Tübingen technique (31 cases)]. 61
17384539 2007
36
Cancer incidence in the age range 0-34 years: historical and actual status in Denmark. 61
16380984 2006
37
[Primary cutaneous extraskeletal Ewing's sarcoma]. 61
16446642 2005
38
Dermatofibrosarcoma protuberans treated at a single institution: a surgical disease with a high cure rate. 61
16234529 2005
39
[Laparoscopic and general surgery guided by open interventional magnetic resonance]. 61
15494679 2004
40
Resection of soft tissue sarcomas with intra-operative magnetic resonance guidance. 61
11793466 2002
41
Effects of synthetic bis-beta-chloroethylamine estrogen derivatives on proliferation of skin sarcoma cells. 61
11022259 2000
42
Micrographic surgery ('slow Mohs') in cutaneous sarcomas. 61
10026400 1999
43
Malignant fibrous histiocytoma and atypical fibroxanthoma in renal transplant recipients. 61
10026398 1999
44
Dermatofibrosarcoma protuberans and the Bednar tumor: treatment in the pediatric population. 61
9869058 1998
45
[Cutaneous and subcutaneous sarcomas]. 61
9926474 1998
46
[Cutaneous cancers in Togo]. 61
9435809 1997
47
Highly selective infusions of supradose Cisplatin for cranial base malignancies. 61
17171160 1994
48
Dermatofibrosarcoma protuberans presenting in infancy and childhood. 61
1939782 1991
49
Comparison of dose distribution by means of bolus versus water bath phantom techniques in treatment of cutaneous sarcoma of an extremity. 61
2127359 1990
50
Postirradiation hemangiosarcoma of the chest wall. Report of a case. 61
2994373 1985

Variations for Skin Sarcoma

Expression for Skin Sarcoma

Search GEO for disease gene expression data for Skin Sarcoma.

Pathways for Skin Sarcoma

Pathways related to Skin Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 PECAM1 MLANA KIT CD34
2 11.4 KIT CD68 CD34
3 11.11 PDGFB KIT CD34
4 10.4 PDGFB COL1A1

GO Terms for Skin Sarcoma

Biological processes related to Skin Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.5 PECAM1 COL1A1 CD34
2 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.37 PDGFB KIT
3 hemopoiesis GO:0030097 9.33 PDGFB KIT CD34
4 paracrine signaling GO:0038001 9.26 PDGFB CD34
5 positive regulation of cell migration GO:0030335 9.26 PECAM1 PDGFB KIT COL1A1
6 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Molecular functions related to Skin Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet-derived growth factor binding GO:0048407 8.62 PDGFB COL1A1

Sources for Skin Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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