MCID: SKN021
MIFTS: 33

Skin Sarcoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Skin Sarcoma

MalaCards integrated aliases for Skin Sarcoma:

Name: Skin Sarcoma 12 15 73
Cutaneous Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2687
NCIt 50 C5585
UMLS 73 C0856900

Summaries for Skin Sarcoma

MalaCards based summary : Skin Sarcoma, also known as cutaneous sarcoma, is related to ring chromosome 4 and bednar tumor. An important gene associated with Skin Sarcoma is PDGFB (Platelet Derived Growth Factor Subunit B), and among its related pathways/superpathways are Pathways in cancer and Glioma. The drugs Anti-Infective Agents and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Skin Sarcoma

Diseases related to Skin Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 ring chromosome 4 11.0 COL1A1 PDGFB
2 bednar tumor 10.9 COL1A1 PDGFB
3 leiomyoma cutis 10.8 CLEC2A FH
4 malignant spindle cell melanoma 10.8 MITF NGFR
5 orbital cancer 10.7 EWSR1 SYP
6 pilomyxoid astrocytoma 10.7 COL1A1 SYP
7 dermis tumor 10.7 CD163 COL1A1 PDGFB
8 cauda equina neoplasm 10.7 EWSR1 SYP
9 bone osteosarcoma 10.7 CDK4 EWSR1
10 gastric leiomyoma 10.6 CALD1 FH
11 extraosseous chondrosarcoma 10.6 EWSR1 SYP
12 fibrous histiocytoma 10.6 CD163 EWSR1 MITF
13 lung combined type small cell carcinoma 10.6 CALD1 SYP
14 olfactory neuroblastoma 10.6 EWSR1 NGFR SYP
15 melanoma, cutaneous malignant 1 10.6 CDK4 CDKN2B MITF
16 ewing's family of tumors 10.5 CDK4 CDKN2B EWSR1
17 bone epithelioid hemangioma 10.5 CD34 EWSR1
18 histiocytoma 10.5 CD163 CDK4 EWSR1
19 adult fibrosarcoma 10.4 COL1A1 PDGFB
20 breast angiosarcoma 10.4 CD34 MITF
21 central nervous system sarcoma 10.4 CD163 CD68
22 vulvar sarcoma 10.4 CD34 EWSR1
23 pigmented basal cell carcinoma 10.4 CLEC2A FOXO4 MITF
24 extraosseous osteosarcoma 10.4 CD34 CDK4
25 breast myofibroblastoma 10.4 CALD1 CD34
26 intravascular fasciitis 10.4 CALD1 CD34
27 lymphoplasmacyte-rich meningioma 10.4 CD163 CD68
28 deep leiomyoma 10.4 CALD1 CD34
29 brain sarcoma 10.4 CD163 CD68
30 glomangiomyoma 10.4 CALD1 CD34
31 dermatofibrosarcoma protuberans 10.3 CD34 COL1A1 PDGFB
32 breast leiomyosarcoma 10.3 CALD1 CD34
33 malignant mesenchymoma 10.3 CALD1 CDK4 EWSR1
34 conventional angiosarcoma 10.3 CD34 SYP
35 balloon cell malignant melanoma 10.3 CD68 FOXO4
36 skin melanoma 10.3 CDK4 CDKN2B MITF
37 inflamed seborrheic keratosis 10.3 CD68 CLEC2A
38 plexiform schwannoma 10.3 CD34 NGFR
39 chondrosarcoma, extraskeletal myxoid 10.3 CREB3L2 EWSR1 SYP
40 cell type benign neoplasm 10.3 CD34 FH SYP
41 meninges sarcoma 10.3 CD34 CREB3L2
42 liver sarcoma 10.2 CD68 PDGFB
43 malignant fibrous histiocytoma of bone 10.2 CALD1 CDK4
44 sclerosing liposarcoma 10.2 CD34 CREB3L2
45 petroclival meningioma 10.2 CD163 CD68
46 venous hemangioma 10.1 CD34 SYP
47 liposarcoma 10.1 CD34 CDK4 EWSR1
48 retina lymphoma 10.1 CD34 CD68
49 inflammatory leiomyosarcoma 10.1 CALD1 CD68
50 deep angioma 10.1 CD34 CREB3L2

Graphical network of the top 20 diseases related to Skin Sarcoma:



Diseases related to Skin Sarcoma

Symptoms & Phenotypes for Skin Sarcoma

GenomeRNAi Phenotypes related to Skin Sarcoma according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.55 CD163
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.55 CD163
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.55 CD163
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.55 CD163
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.55 CD163
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.55 EWSR1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.55 EZH2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.55 EWSR1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.55 CDK4 EWSR1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.55 CD163 CDK4 EWSR1 EZH2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.55 EWSR1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.55 EWSR1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.55 CD163

MGI Mouse Phenotypes related to Skin Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 EZH2 CD163 FH FOXO4 CD34 MITF
2 hematopoietic system MP:0005397 10.02 EZH2 CD163 CD34 MITF CD68 NGFR
3 immune system MP:0005387 9.85 COL1A1 EZH2 CD163 CD34 MITF CD68
4 integument MP:0010771 9.56 EZH2 CD34 MITF NGFR CDK4 PDGFB
5 neoplasm MP:0002006 9.1 COL1A1 EZH2 FOXO4 CD34 CDK4 CDKN2B

Drugs & Therapeutics for Skin Sarcoma

Drugs for Skin Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents Phase 2
2 Antiviral Agents Phase 2
3 Carboxymethylcellulose Sodium Phase 2
4 Cathartics Phase 2
5 Gastrointestinal Agents Phase 2
6 Interferon Inducers Phase 2
7 interferons Phase 2
8 Laxatives Phase 2
9 Poly I-C Phase 2
10 Poly ICLC Phase 2
11 Vaccines Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Solid Tumors With Intratumoral Hiltonol® (Poly-ICLC) Terminated NCT01984892 Phase 2 Poly-ICLC
2 Infrared Thermography in Finding Skin Lesions in Patients With Kaposi's Sarcoma Unknown status NCT00265902 Not Applicable

Search NIH Clinical Center for Skin Sarcoma

Genetic Tests for Skin Sarcoma

Anatomical Context for Skin Sarcoma

MalaCards organs/tissues related to Skin Sarcoma:

41
Skin

Publications for Skin Sarcoma

Articles related to Skin Sarcoma:

# Title Authors Year
1
Effects of synthetic bis-beta-chloroethylamine estrogen derivatives on proliferation of skin sarcoma cells. ( 11022259 )
2000
2
Multiple carcinomatous growths and skin sarcoma in a patient with chronic roentgen-ray dermatosis. ( 13927643 )
1963

Variations for Skin Sarcoma

Expression for Skin Sarcoma

Search GEO for disease gene expression data for Skin Sarcoma.

Pathways for Skin Sarcoma

GO Terms for Skin Sarcoma

Biological processes related to Skin Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.8 COL1A1 CREB3L2 FOXO4 MITF PDGFB
2 multicellular organism development GO:0007275 9.8 ACRV1 CDK4 CREB3L2 FOXO4 MITF NGFR
3 regulation of cell proliferation GO:0042127 9.62 CDK4 EZH2 MITF NGFR
4 positive regulation of smooth muscle cell migration GO:0014911 9.43 FOXO4 PDGFB
5 response to hyperoxia GO:0055093 9.37 CDK4 COL1A1
6 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.16 CDK4 CDKN2B
7 paracrine signaling GO:0038001 8.96 CD34 PDGFB
8 positive regulation of fibroblast proliferation GO:0048146 8.8 CDK4 PDGFB S100A6

Molecular functions related to Skin Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tropomyosin binding GO:0005523 8.96 CALD1 S100A6
2 platelet-derived growth factor binding GO:0048407 8.62 COL1A1 PDGFB

Sources for Skin Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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