Aliases & Classifications for Skin Tag

MalaCards integrated aliases for Skin Tag:

Name: Skin Tag 12 15 70
Fibroepithelial Polyp of Skin 12
Fibroepithelial Polyp 12
Gardner Fibroma 70
Cutaneous Tag 12
Soft Fibroma 12
Skin Tags 54

Classifications:



External Ids:

Disease Ontology 12 DOID:6873
NCIt 50 C3374
SNOMED-CT 67 156440000
UMLS 70 C0037293 C1708187

Summaries for Skin Tag

Disease Ontology : 12 A reactive cutaneous fibrous lesion that is characterized by a small, painless, flesh colored peduncle arising on the surface of the skin, and develops from areas of friction, or may be associated with HPV virus, or Crohn's disease.

MalaCards based summary : Skin Tag, also known as fibroepithelial polyp of skin, is related to pleomorphic lipoma and colorectal adenoma, and has symptoms including macule An important gene associated with Skin Tag is PTCH1 (Patched 1), and among its related pathways/superpathways are mTOR signaling pathway (KEGG) and Senescence and Autophagy in Cancer. The drugs Povidone and Povidone-iodine have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and eye, and related phenotypes are homeostasis/metabolism and cellular

Wikipedia : 73 A skin tag, or acrochordon (pl. acrochorda), is a small benign tumor that forms primarily in areas where... more...

Related Diseases for Skin Tag

Diseases related to Skin Tag via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 286)
# Related Disease Score Top Affiliating Genes
1 pleomorphic lipoma 30.4 SERPINA3 CD34
2 colorectal adenoma 30.3 LEP INS IGF1
3 fibroma 30.2 SERPINA3 PTCH1 FLCN CD34
4 amenorrhea 30.0 SHBG LEP INS IGF1
5 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 30.0 INS IGFBP3 IGF1
6 congenital heart defects, hamartomas of tongue, and polysyndactyly 29.9 GLI3 FLCN
7 hydrocephalus 29.8 SERPINA3 PTCH1 IGF1 FGFR2
8 glucose intolerance 29.8 SHBG LEP INS IGF1
9 hyperinsulinism 29.8 SHBG LEP INS IGFBP3 IGF1
10 hyperandrogenism 29.6 SHBG INS IGFBP3 IGF1
11 acanthosis nigricans 29.5 SHBG LEP INS IGF1 FGFR2
12 acromegaly 29.4 SHBG LEP INS IGFBP3 IGF1
13 hypothyroidism 29.4 SHBG LEP INS IGFBP3 IGF1
14 insulin-like growth factor i 29.4 SHBG LEP INS IGFBP3 IGF1
15 chromosome 2q35 duplication syndrome 29.2 PTCH1 LMBR1 IQCE GLI3 FREM1 FGFR2
16 body mass index quantitative trait locus 11 29.1 SHBG SERPINA3 LEP INS IGFBP3 IGF1
17 fibroepithelial polyp of urethra 11.5
18 vulva fibroepithelial polyp 11.5
19 fibroepithelial polyp of the anus 11.5
20 mandibulofacial dysostosis, guion-almeida type 11.2
21 encephalocraniocutaneous lipomatosis 11.2
22 lumbar syndrome 11.1
23 kaufman oculocerebrofacial syndrome 11.1
24 oculoectodermal syndrome 11.1
25 oculoauriculofrontonasal syndrome 11.1
26 hemorrhoid 11.0
27 beare-stevenson cutis gyrata syndrome 11.0
28 wolf-hirschhorn syndrome 11.0
29 microphthalmia, syndromic 1 11.0
30 emanuel syndrome 11.0
31 auriculo-condylar syndrome 11.0
32 craniofacial microsomia 11.0
33 intellectual disability - hypoplastic corpus callosum - preauricular tag 11.0
34 hydronephrosis 10.6
35 familial episodic pain syndrome 10.4
36 transitional cell carcinoma 10.4
37 pineal region choriocarcinoma 10.4 IGF1 CD34
38 basal cell carcinoma, infundibulocystic 10.4 PTCH1 IQCE
39 acidophil adenoma 10.4 INS IGF1
40 genetic obesity 10.3 LEP IGF1
41 metatypical basal cell carcinoma 10.3 PTCH1 CD34
42 benign pleural mesothelioma 10.3 INS CD34
43 intussusception 10.3
44 pituitary infarct 10.3 INS IGF1
45 small intestine leiomyoma 10.3 PTCH1 CD34
46 retroperitoneal hemangiopericytoma 10.3 INS CD34
47 sarcomatoid squamous cell skin carcinoma 10.3 SERPINA3 CD34
48 lung sarcoma 10.3 SERPINA3 CD34
49 pica disease 10.3 LEP INS
50 scleredema adultorum 10.3 INS CD34

Graphical network of the top 20 diseases related to Skin Tag:



Diseases related to Skin Tag

Symptoms & Phenotypes for Skin Tag

UMLS symptoms related to Skin Tag:


macule

MGI Mouse Phenotypes related to Skin Tag:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 CD34 DOP1B FGFR2 FLCN FNIP1 GLI3
2 cellular MP:0005384 10.22 CD34 FGFR2 FLCN FNIP1 GLI3 IGF1
3 integument MP:0010771 10.17 CD34 DOP1B FGFR2 FREM1 GLI3 IGF1
4 limbs/digits/tail MP:0005371 10.06 FGFR2 FREM1 GLI3 IGF1 IGFBP3 IQCE
5 muscle MP:0005369 9.97 FGFR2 FNIP1 FREM1 IGF1 IGFBP3 INS
6 neoplasm MP:0002006 9.87 CD34 FGFR2 FLCN FNIP1 IGF1 LEP
7 renal/urinary system MP:0005367 9.81 FGFR2 FLCN FNIP1 FREM1 GLI3 IGF1
8 skeleton MP:0005390 9.7 DOP1B FGFR2 FREM1 GLI3 IGF1 IGFBP3
9 pigmentation MP:0001186 9.65 FGFR2 GLI3 IGFBP3 LEP PTCH1
10 vision/eye MP:0005391 9.28 FGFR2 FREM1 GLI3 IGFBP3 INS IQCE

Drugs & Therapeutics for Skin Tag

Drugs for Skin Tag (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Povidone Approved 9003-39-8 131751496
2
Povidone-iodine Approved 25655-41-8
3
Ethanol Approved 64-17-5 702
4
silver nitrate Approved, Investigational 7761-88-8
5
Iodine Approved, Investigational 7553-56-2 807
6
Acetylcholine Approved, Investigational 51-84-3 187
7
Chlorhexidine Approved, Vet_approved 55-56-1 2713 9552079
8
Cadexomer iodine Experimental 94820-09-4
9 Pharmaceutical Solutions
10 Anti-Bacterial Agents
11 Anti-Infective Agents
12 Anesthetics
13 Anti-Infective Agents, Local
14 Neurotransmitter Agents
15 abobotulinumtoxinA
16 Cholinergic Agents
17 Botulinum Toxins
18 Botulinum Toxins, Type A
19 Chlorhexidine gluconate
20 Hemostatics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Craniofacial Microsomia: Longitudinal Outcomes in Children Pre-Kindergarten (CLOCK) Unknown status NCT02224677
2 Research on Current Prototypes of the Digiclamp. Short Term and Long Term Outcomes of Treating Adults With Achrocordons (Skin Tags) Completed NCT03259295
3 Randomized Clinical Trial on Traditional Healing Versus Moist Healing Environment (MHE) Applied to Minor Surgery in the Exeresis of Skin Tags Completed NCT04161274
4 Postero-lateral Internal Sphincterotomy vs Botulinum Toxin Injection in the Treatment of Chronic Anal Fissure: A Randomized Controlled Trial Recruiting NCT03920449 Botulinum Toxins
5 Open Label, Prospective, Single-Center Pilot Study to Evaluate the Effect of Multiple Passes on Port Wine Stain Treatments With the Cutera Excel V™ Laser. Suspended NCT04103164

Search NIH Clinical Center for Skin Tag

Genetic Tests for Skin Tag

Anatomical Context for Skin Tag

MalaCards organs/tissues related to Skin Tag:

40
Skin, Colon, Eye, Spinal Cord, Small Intestine, Prostate

Publications for Skin Tag

Articles related to Skin Tag:

(show top 50) (show all 244)
# Title Authors PMID Year
1
Acrochordons as a presenting sign of nevoid basal cell carcinoma syndrome. 54 61
11312426 2001
2
Novel Findings in Floating-Harbor Syndrome and a Mini-Review of the Literature. 61
33776628 2021
3
Tethered spinal cord syndrome in adults in the MRI era: recognition, pathology, and long-term objective outcomes. 61
33740756 2021
4
Histomorphology of the lesions of the umbilicus: Are we naïve about the navel? 61
33433415 2021
5
Opioid Consumption Patterns After Anorectal Operations: Development of an Institutional Prescribing Guideline. 61
33306536 2021
6
Congenital midline cervical cleft: An easily misdiagnosed disease. 61
33663147 2020
7
A Comparison of Ferric Subsulfate Solution, Silver Nitrate, and Aluminum Chloride for Pain Assessment, Time to Hemostasis, and Cosmesis in Acrochordon Snip Excision. 61
33488917 2020
8
The role of insulin-like growth factor in Acrochordon Etiopathology. 61
33143702 2020
9
Hemiscrotal agenesis: a novel phenotype of a rare malformation. 61
33248450 2020
10
Anal skin tag - an unusual presenting feature of food protein-induced allergic proctocolitis in a neonate. 61
33216045 2020
11
Skin tags imaged by reflectance confocal microscopy, optical coherence tomography and multispectral optoacoustic tomography at the bedside. 61
33040376 2020
12
High expression of disabled homolog 2-interacting protein contributes to tumor development and proliferation in cutaneous squamous cell carcinoma. 61
33240980 2020
13
Change of the diagnostic distribution in applicants to dermatology after COVID-19 pandemic: What it whispers to us? 61
32530503 2020
14
Bilateral cervical chondrocutaneous branchial remnants: A case report and a review of the literature. 61
32664135 2020
15
Using a straight mosquito hemostat for hemostasis in skin tag removal. 61
32707257 2020
16
Ligaclip for Preauricular Skin Tags in the Newborn. 61
32512592 2020
17
TRANSANAL HAEMORRHOIDAL DEARTERIALIZATION WITH MUCOPEXY (THD-M) FOR TREATMENT OF HEMORRHOIDS: IS IT APPLICABLE IN ALL GRADES? BRAZILIAN MULTICENTER STUDY. 61
32844877 2020
18
Giant Fibroepithelial Polyps: Why do they Grow Excessively? 61
32617069 2020
19
Surgical excision of a giant soft fibroma of the labia majora covered with a pudendal artery perforator flap. 61
31964133 2020
20
Hemorrhoidectomy and Excision of Skin Tags in IBD: Harbinger of Doom or Simply a Disease Running Its Course? 61
31580261 2019
21
[Anal fissure]. 61
32237626 2019
22
Rhabdomyomatous mesenchymal hamartoma developed at an unexpected location. 61
31560504 2019
23
Infarcted Giant Skin Tag. 61
30072024 2019
24
Anoplasty with skin tag flap for the treatment of chronic anal fissure. 61
31432983 2019
25
Evaluating the Accuracy of Hemorrhoids: Comparison Among Specialties and Symptoms. 61
31188188 2019
26
ApamargaKsharasutra application and open lateral internal sphincterotomy in the management of Parikartika (chronic fissure‑in‑ano): A randomized controlled clinical trial. 61
33281393 2019
27
Surgical Correction of Craniofacial Microsomia: Evaluation of Interventions in 565 Patients at Three Major Craniofacial Units. 61
31033829 2019
28
Association of Skin Tag with Metabolic Syndrome and its Components: A Case-control Study from Eastern India. 61
31149572 2019
29
Correlation between Serum Leptin Level with Type and Number of Lesion Skin Tag. 61
30740160 2019
30
Heterotopic respiratory mucosa in the scalp overlying abnormal bony island in the skull linked to maternal misoprostol use, literature review and surgical experience. 61
31129433 2019
31
Coccygeal Polypoid Eccrine Nevus Presenting as a Skin Tag: Case Report and Review of the Literature. 61
31210737 2019
32
External hemorrhoidal disease in child and teenage: Clinical presentations and risk factors. 61
31258578 2019
33
Surgical correction for Tessier number 7 craniofacial cleft using a medially overcorrected design. 61
30685937 2019
34
Primary vaginal adenocarcinoma of intestinal type or occult metastatic colon cancer: a diagnostic dilemma from a vaginal skin tag. 61
31015769 2019
35
Is Skin Tag Associated with Diabetic Macro and Microangiopathy? 61
30129497 2018
36
A 12-day-old Male With a "Skin Tag" on the Chin: Answer. 61
30339567 2018
37
A 12-Day-Old Male With a "Skin Tag" on the Chin: Challenge. 61
30339569 2018
38
Skin tag over the scrotum in infancy. 61
30178582 2018
39
Skin tag over the scrotum in infancy. 61
30178584 2018
40
Pyriform-shaped soft fibroma of the nipple in a male patient. 61
29781192 2018
41
An Unusual Presentation of Conjunctival Dermolipoma With a Skin Tag. 61
29420382 2018
42
Preliminary report: Surgical outcomes following genitoplasty in children with moderate to severe genital atypia. 61
29398588 2018
43
Investigation of copy number variations on chromosome 21 detected by comparative genomic hybridization (CGH) microarray in patients with congenital anomalies. 61
31061677 2018
44
Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases. 61
29090469 2018
45
Congenital Midline Cervical Cleft and W-Plasty: Our Experience. 61
30627168 2018
46
Encephalocraniocutaneous lipomatosis: A case report with review of literature. 61
28707961 2017
47
The Correlation between Body Mass Index with the Occurrence of Skin Tag. 61
28698740 2017
48
Uptake of an Acrochordon Incidentally Detected on 68Ga Prostate-Specific Membrane Antigen PET/CT. 61
28368887 2017
49
Solitary cutaneous focal mucinosis: A clinicopathological study of 11 cases of soft fibroma-like cutaneous mucinous lesions. 61
27450934 2017
50
Eccrine Poroma of the Postauricular Area. 61
28913302 2017

Variations for Skin Tag

Expression for Skin Tag

Search GEO for disease gene expression data for Skin Tag.

Pathways for Skin Tag

Pathways related to Skin Tag according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.82 INS IGF1 FNIP1 FLCN FGFR2
2 11.52 INS IGFBP3 IGF1
3 11.25 PTCH1 IGF1 GLI3
4 11.08 PTCH1 IQCE GLI3
5 11 LEP INS IGFBP3 IGF1 CD34

GO Terms for Skin Tag

Cellular components related to Skin Tag according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 SHBG SERPINA3 LEP INS IGFBP3 IGF1
2 insulin-like growth factor ternary complex GO:0042567 8.96 IGFBP3 IGF1
3 insulin-like growth factor binding protein complex GO:0016942 8.62 IGFBP3 IGF1

Biological processes related to Skin Tag according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10.01 PTCH1 LEP GLI3 FNIP1 FLCN FGFR2
2 in utero embryonic development GO:0001701 9.83 PTCH1 GLI3 FLCN FGFR2
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.72 LEP INS IGF1
4 regulation of protein phosphorylation GO:0001932 9.69 LEP FNIP1 FLCN
5 pattern specification process GO:0007389 9.63 SYNGAP1 PTCH1 GLI3
6 embryonic digestive tract morphogenesis GO:0048557 9.58 GLI3 FGFR2
7 positive regulation of glycogen biosynthetic process GO:0045725 9.58 INS IGF1
8 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.57 IGFBP3 IGF1
9 prostate gland development GO:0030850 9.56 PTCH1 GLI3
10 embryonic organ development GO:0048568 9.54 PTCH1 GLI3 FGFR2
11 positive regulation of TOR signaling GO:0032008 9.5 LEP FNIP1 FLCN
12 bone mineralization involved in bone maturation GO:0035630 9.49 LEP IGF1
13 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 9.48 PTCH1 GLI3
14 wound healing GO:0042060 9.46 INS IGF1 GLI3 FGFR2
15 negative regulation of mitochondrion organization GO:0010823 9.43 FNIP1 FLCN
16 regulation of pro-B cell differentiation GO:2000973 9.4 FNIP1 FLCN
17 cell differentiation involved in kidney development GO:0061005 9.26 PTCH1 GLI3
18 limb morphogenesis GO:0035108 9.13 PTCH1 IQCE GLI3
19 positive regulation of MAPK cascade GO:0043410 9.02 LEP INS IGFBP3 IGF1 FGFR2

Molecular functions related to Skin Tag according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor receptor binding GO:0005159 8.62 INS IGF1

Sources for Skin Tag

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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