MCID: SKL030
MIFTS: 25

Skull Base Cancer

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Skull Base Cancer

MalaCards integrated aliases for Skull Base Cancer:

Name: Skull Base Cancer 12 15
Tumors of Skull Base 12
Skull Base Neoplasms 45

Classifications:



External Ids:

Disease Ontology 12 DOID:3842
MeSH 45 D019292
NCIt 51 C4676
UMLS 74 C0376527

Summaries for Skull Base Cancer

MalaCards based summary : Skull Base Cancer, also known as tumors of skull base, is related to cranial nerve palsy and intracranial sinus thrombosis. An important gene associated with Skull Base Cancer is CCDC174 (Coiled-Coil Domain Containing 174). The drugs Aminolevulinic acid and Photosensitizing Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and pituitary.

Related Diseases for Skull Base Cancer

Graphical network of the top 20 diseases related to Skull Base Cancer:



Diseases related to Skull Base Cancer

Symptoms & Phenotypes for Skull Base Cancer

Drugs & Therapeutics for Skull Base Cancer

Drugs for Skull Base Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 1 106-60-5 137
2 Photosensitizing Agents Phase 1
3 Dermatologic Agents Phase 1
4 Central Nervous System Depressants Not Applicable
5 Anesthetics Not Applicable
6 Hemostatics Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Fluorescence Guided Resection of Brain Tumors Completed NCT00870779 Phase 1 5-aminolevulinic acid
2 ICG Use in Angiography for Nasoseptal Flap Harvest Completed NCT02117310 Not Applicable indocyanine green
3 Barrow Nasal Inventory Survey Completed NCT01322945
4 Molecular and Cellular Characterization of Skull Base Tumors Recruiting NCT03759717
5 Effects on the Awakening With Laryngeal Mask vs Endotracheal Tube in Endoscopic Endonasal Transsphenoidal Base Surgery Recruiting NCT02988804 Not Applicable
6 Cranial Nerves Tractography Recruiting NCT02978911 Not Applicable
7 In-Room PET in Proton Radiation Therapy Recruiting NCT01228448 Not Applicable
8 Improvement of Outcomes in Draf III/Endoscopic Modified Lothrop Procedure Recruiting NCT02981017 Not Applicable
9 Impact of Nasoseptal Flap Harvest Technique on Olfaction Following Endoscopic Transsphenoidal Pituitary Surgery Recruiting NCT03773705 Not Applicable
10 Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes Recruiting NCT01200680
11 Skull Base Reconstruction After Endonasal Cranio-endoscopic Resection Using Autologus Grafts Active, not recruiting NCT03448614

Search NIH Clinical Center for Skull Base Cancer

Cochrane evidence based reviews: skull base neoplasms

Genetic Tests for Skull Base Cancer

Anatomical Context for Skull Base Cancer

MalaCards organs/tissues related to Skull Base Cancer:

42
Brain, Bone, Pituitary

Publications for Skull Base Cancer

Articles related to Skull Base Cancer:

# Title Authors Year
1
Management of lateral skull base cancer: United Kingdom National Multidisciplinary Guidelines. ( 27841125 )
2016
2
Improvement in survival during the past 4 decades among patients with anterior skull base cancer. ( 22076799 )
2012
3
On-board imaging validation of optically guided stereotactic radiosurgery positioning system for conventionally fractionated radiotherapy for paranasal sinus and skull base cancer. ( 21543166 )
2011
4
Intraoperative radiotherapy for head and neck and skull base cancer. ( 12599289 )
2003
5
Postoperative irradiation of patients with malignant tumors of skull base. ( 8667987 )
1996
6
Intraoperative radiotherapy of skull base cancer. ( 1851521 )
1991

Variations for Skull Base Cancer

Expression for Skull Base Cancer

Search GEO for disease gene expression data for Skull Base Cancer.

Pathways for Skull Base Cancer

GO Terms for Skull Base Cancer

Molecular functions related to Skull Base Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type peptidase activity GO:0008236 8.96 TMPRSS3 TMPRSS4
2 scavenger receptor activity GO:0005044 8.62 TMPRSS3 TMPRSS4

Sources for Skull Base Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....