MCID: SKL030
MIFTS: 33

Skull Base Cancer

Categories: Bone diseases, Cancer diseases
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Aliases & Classifications for Skull Base Cancer

MalaCards integrated aliases for Skull Base Cancer:

Name: Skull Base Cancer 11 14
Tumors of Skull Base 11
Skull Base Neoplasms 43

Classifications:



External Ids:

Disease Ontology 11 DOID:3842
MeSH 43 D019292
NCIt 49 C4676
UMLS 71 C0376527

Summaries for Skull Base Cancer

MalaCards based summary: Skull Base Cancer, also known as tumors of skull base, is related to neurilemmoma and adenoma. An important gene associated with Skull Base Cancer is TRAF7 (TNF Receptor Associated Factor 7), and among its related pathways/superpathways are Signal Transduction and Malignant pleural mesothelioma. The drugs Aminolevulinic acid and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include bone and brain, and related phenotypes are Increased proliferation and homeostasis/metabolism

Related Diseases for Skull Base Cancer

Diseases related to Skull Base Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 neurilemmoma 29.7 SMARCB1 SERPINA3 NF2 AKT1
2 adenoma 29.6 SSTR2 SST PIK3CA AKT1
3 chordoma 29.6 TERT SMARCB1 SERPINA3 AKT1
4 mixed cell type cancer 29.6 SERPINA3 PIK3CA PGR
5 meningioma, familial 27.1 TRAF7 TERT SSTR2 SST SMO SMARCE1
6 tuberculum sellae meningioma 10.3 TRAF7 NF2
7 sella turcica neoplasm 10.3 TRAF7 NF2
8 intraneural perineurioma 10.3 TRAF7 NF2
9 cerebellopontine angle meningioma 10.3 SMARCE1 NF2
10 foramen magnum meningioma 10.2 TRAF7 POLR2A NF2
11 sphenoorbital meningioma 10.2 TRAF7 SMARCE1 NF2
12 olfactory neuroblastoma 10.2
13 cerebrospinal fluid leak 10.2
14 endocrine pancreas disease 10.2 SSTR2 SST
15 tricuspid valve stenosis 10.2 SST SERPINA3
16 carcinoid tumors, intestinal 10.2 SSTR2 SST
17 full schwannomatosis 10.2 SMARCB1 NF2
18 posterior pituitary gland neoplasm 10.2 SMARCB1 NF2
19 gastrointestinal neuroendocrine tumor 10.2 SSTR2 SST
20 pineal region meningioma 10.2 SMARCB1 NF2
21 plexiform schwannoma 10.2 SMARCB1 NF2
22 schwannomatosis 1 10.2 SMARCB1 NF2
23 cerebellopontine angle tumor 10.1 SMARCB1 NF2
24 cellular schwannoma 10.1 SMARCB1 NF2
25 proliferative fasciitis 10.1 SMARCB1 SERPINA3
26 carney complex variant 10.1 SST SERPINA3 NF2
27 pulmonary neuroendocrine tumor 10.1 SSTR2 SST
28 pancreatic endocrine carcinoma 10.1 SSTR2 SST SERPINA3
29 mucosal melanoma 10.1
30 bell's palsy 10.1
31 facial paralysis 10.1
32 atypical neurofibroma 10.1 SMARCB1 NF2
33 melanotic neurilemmoma 10.1 SMARCB1 NF2
34 schwannoma of twelfth cranial nerve 10.1 SMARCB1 NF2
35 islet cell tumor 10.1 SSTR2 SST SERPINA3
36 chondroid chordoma 10.1 SMARCB1 SERPINA3
37 hypoglossal nerve disease 10.1 SMARCB1 NF2
38 sarcomatoid squamous cell skin carcinoma 10.1 SMARCB1 SERPINA3
39 neurofibromatosis, type i 10.1 SST NF2 AKT1
40 esophageal neuroendocrine tumor 10.1 SSTR2 SST
41 neurofibromatosis, type ii 10.1 TRAF7 SMARCB1 NF2
42 microcystic meningioma 10.1 TRAF7 SSTR2 SMARCE1 NF2
43 spinal cord ependymoma 10.1 SMARCB1 NF2
44 endocrine organ benign neoplasm 10.1 SSTR2 SST SERPINA3
45 kidney rhabdoid cancer 10.1 SMARCB1 SERPINA3
46 peripheral nerve schwannoma 10.1 SMARCB1 SERPINA3 NF2
47 lung oat cell carcinoma 10.1 PIK3CA AKT1
48 neurilemmomatosis 10.1 SMARCE1 SMARCB1 NF2
49 spindle cell sarcoma 10.0 SMARCB1 SERPINA3 NF2
50 petroclival meningioma 10.0 TRAF7 POLR3C NF2

Graphical network of the top 20 diseases related to Skull Base Cancer:



Diseases related to Skull Base Cancer

Symptoms & Phenotypes for Skull Base Cancer

GenomeRNAi Phenotypes related to Skull Base Cancer according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Skull Base Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 AKT1 KLF4 NF2 PGR PIK3CA POLR2A
2 nervous system MP:0003631 10.07 AKT1 KLF4 NF2 PIK3CA POLR2A SMARCB1
3 neoplasm MP:0002006 10.01 AKT1 KLF4 NF2 PGR PIK3CA POLR2A
4 immune system MP:0005387 9.93 AKT1 KLF4 NF2 PGR PIK3CA POLR2A
5 digestive/alimentary MP:0005381 9.91 KLF4 NF2 PIK3CA POLR2A SMARCB1 SMO
6 mortality/aging MP:0010768 9.73 AKT1 KLF4 NF2 PGR PIK3CA POLR2A
7 integument MP:0010771 9.32 AKT1 KLF4 NF2 PGR PIK3CA POLR2A

Drugs & Therapeutics for Skull Base Cancer

Drugs for Skull Base Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 2 106-60-5 137
2 Anesthetics Phase 2
3 Photosensitizing Agents Phase 2
4 Pharmaceutical Solutions Phase 2
5 Dermatologic Agents Phase 2

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Serial Magnetic Resonance Imaging of Longitudinal Radiotherapy-Attributable Normal Tissue Injury Recruiting NCT04265430 Phase 4
2 The Role of 5-Aminolevulinic Acid Fluorescence-Guided Surgery in Head and Neck Cancers: a Pilot Trial Recruiting NCT05101798 Phase 2 5-Aminolevulinic acid Hydrochloride
3 Skull Base Reconstruction After Endonasal Cranio-endoscopic Resection Using Autologus Grafts Unknown status NCT03448614
4 Evaluation of Acupuncture Effects for Complications After Surgery of Cerebellopontine Angle Tumor in Skull Base Unknown status NCT04249921
5 Proposal for Intraoperative Administration of Intravenous Indocyanine Green to Evaluate Sphenopalatine Artery Location and Patency in Harvesting and Positioning a Pedicled Nasoseptal Mucosal Flap in Endoscopic Endonasal Cranial Base Surgery Completed NCT02117310 indocyanine green
6 Effects on the Awakening With Laryngeal Mask vs Endotracheal Tube in Endoscopic Endonasal Transsphenoidal Base Surgery Completed NCT02988804
7 Proposal for Intraoperative Administration of Intravenous Indocyanine Green to Evaluate Position of the Optic Canal, Position of the Internal Carotid Arteries, Tumor Vascularization, and Vessel Encasement in Endoscopic Endonasal Cranial Base Surgery Completed NCT03072186
8 Pilot Study of In-Room PET in Proton Radiation Therapy Completed NCT01228448
9 Prospective Observational Study of Sinonasal and Skull-base Tumours Management in a Tertiary Referral Otorhinolaryngology Service Recruiting NCT05607888
10 Molecular and Cellular Characterization of Skull Base Tumors Recruiting NCT03759717
11 Assessment of Predicted LET and Dosimetry in Relation to White Matter Changes in Pediatric Patients Following Proton Therapy for Primary Central Nervous System and Base of Skull Malignancies: A Pilot Study Recruiting NCT04296617
12 Prospective Observational Trial of the Impact of Radiation Dose on Brain Morphology, Volumetric Changes, Endocrine Function, and Neurocognitive Function Following Cranial Radiation Therapy in Children With Brain and Skull Base Tumors. Recruiting NCT03972514
13 Feasibility of Auditory Nerve Test System for Optimization of Simultaneous Translabyrinthine Vestibular Schwannoma Resection With Cochlear Implantation Enrolling by invitation NCT04241679
14 The Utility of Indocyanine Green Fluorescence in Endoscopic Sinonasal and Skull Base Surgery - A Prospective Case-Series and Feasibility Study Not yet recruiting NCT04374448

Search NIH Clinical Center for Skull Base Cancer

Cochrane evidence based reviews: skull base neoplasms

Genetic Tests for Skull Base Cancer

Anatomical Context for Skull Base Cancer

Organs/tissues related to Skull Base Cancer:

MalaCards : Bone, Brain

Publications for Skull Base Cancer

Articles related to Skull Base Cancer:

(show all 32)
# Title Authors PMID Year
1
Resection of the internal carotid artery in selected patients affected by cancer of the skull base. 62
34939715 2022
2
Predictors of distant metastases in sinonasal and skull base cancer patients treated with surgery. 62
34689008 2021
3
Assessment of Radiation-Induced Optic Neuropathy in a Multi-Institutional Cohort of Chordoma and Chondrosarcoma Patients Treated with Proton Therapy. 62
34771490 2021
4
The importance of flaps in reconstruction of locoregionally advanced lateral skull-base cancer defects: a tertiary otorhinolaryngology referral centre experience. 62
33735947 2021
5
Anatomical variations of clivus: a descriptive anatomical study. 62
33483831 2021
6
Managing care for patients with sinonasal and anterior skull base cancers during the COVID-19 pandemic. 62
32415882 2020
7
Mental Health Disorders Associated with Sinonasal and Skull Base Malignancies: A Large Cohort Study. 62
32206538 2020
8
[A new method: lower trapezius island myocutaneous flap to repair surgical defect in lateral skull base cancer after radiotherapy]. 62
32306644 2020
9
Facial Nerve Paralysis after Onyx Embolization of a Jugular Paraganglioma: A Case Report with a Long-Term Follow Up. 62
29518926 2018
10
Tumour stem cells in meningioma: A review. 62
29113852 2018
11
Cognitive function and patient-reported memory problems after radiotherapy for cancers at the skull base: A cross-sectional survivorship study using the Telephone Interview for Cognitive Status and the MD Anderson Symptom Inventory-Head and Neck Module. 62
28763137 2017
12
The cost of major head and neck cancer surgery. 62
28494483 2017
13
The Role of Chemotherapy in the Management of Sinonasal and Ventral Skull Base Malignancies. 62
28160997 2017
14
Impact of Endoscopic Indocyanine Green Fluorescence Imaging on Superselective Intra-arterial Chemotherapy for Recurrent Cancer of the Skull Base. 62
27354602 2016
15
Multiportal combined transnasal transoral transpharyngeal endoscopic approach for selected skull base cancers. 62
26855345 2016
16
Management of lateral skull base cancer: United Kingdom National Multidisciplinary Guidelines. 62
27841125 2016
17
Follow-up after treatment for head and neck cancer: United Kingdom National Multidisciplinary Guidelines. 62
27841136 2016
18
Brain Herniation After Endoscopic Transnasal Resection of Anterior Skull Base Malignancies. 62
26110997 2015
19
Late toxicity of proton beam therapy for patients with the nasal cavity, para-nasal sinuses, or involving the skull base malignancy: importance of long-term follow-up. 62
25135461 2015
20
Improvement in survival during the past 4 decades among patients with anterior skull base cancer. 62
22076799 2012
21
On-board imaging validation of optically guided stereotactic radiosurgery positioning system for conventionally fractionated radiotherapy for paranasal sinus and skull base cancer. 62
21543166 2011
22
Nutrition management of patients with malignancies of the head and neck. 62
21621700 2011
23
Heavy ion radiotherapy during pregnancy. 62
20493478 2010
24
The role of palliative radiosurgery when cancer invades the cavernous sinus. 62
18692328 2009
25
Minimally invasive endoscopic pericranial flap: a new method for endonasal skull base reconstruction. 62
19117286 2009
26
Evaluation of quality of life and psychiatric morbidity in patients with malignant tumours of the skull base. 62
17059620 2006
27
Cranial base strategies for resection of craniopharyngioma in children. 62
16048295 2005
28
Malignant tumors of the anterior skull base. 62
15153838 2004
29
Intraoperative radiotherapy for head and neck and skull base cancer. 62
12599289 2003
30
Medial antebrachial cutaneous nerve: a new donor graft for repair of facial nerve defects at the skull base. 62
9261006 1997
31
Postoperative irradiation of patients with malignant tumors of skull base. 62
8667987 1996
32
Intraoperative radiotherapy of skull base cancer. 62
1851521 1991

Variations for Skull Base Cancer

Expression for Skull Base Cancer

Search GEO for disease gene expression data for Skull Base Cancer.

Pathways for Skull Base Cancer

Pathways related to Skull Base Cancer according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1 13.32 TERT SSTR2 SST SMO POLR2A PIK3CA
2 12.47 TERT PIK3CA NF2 AKT1
3
Show member pathways
11.75 TERT PIK3CA AKT1
4 11.68 PIK3CA KLF4 AKT1
5 11.41 TERT PIK3CA AKT1
6 11.29 SMARCE1 PIK3CA AKT1
7
Show member pathways
10.9 AKT1 PIK3CA TERT
8 10.89 PIK3CA AKT1
9
Show member pathways
10.89 SMO PIK3CA AKT1
10 10.83 PIK3CA AKT1
11 10.79 PIK3CA AKT1
12 10.78 TERT AKT1
13 10.77 PIK3CA AKT1
14
Show member pathways
10.66 SMO SMARCE1 SMARCB1
15 10.65 SMARCE1 SMARCB1
16 10.51 PIK3CA AKT1
17 10.3 PIK3CA NF2 AKT1

GO Terms for Skull Base Cancer

Cellular components related to Skull Base Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bBAF complex GO:0140092 8.92 SMARCE1 SMARCB1

Biological processes related to Skull Base Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell population proliferation GO:0008285 9.96 SSTR2 SST SMARCB1 NF2 KLF4
2 positive regulation of cell differentiation GO:0045597 9.63 SMARCE1 SMARCB1 NF2
3 negative regulation of gene expression GO:0010629 9.4 TERT SMO PIK3CA PGR KLF4 AKT1
4 RNA-templated transcription GO:0001172 9.13 TERT POLR2A

Molecular functions related to Skull Base Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA-dependent RNA polymerase activity GO:0003968 8.8 TERT POLR2A

Sources for Skull Base Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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