MCID: SKL030
MIFTS: 23

Skull Base Cancer

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Skull Base Cancer

MalaCards integrated aliases for Skull Base Cancer:

Name: Skull Base Cancer 12 15
Tumors of Skull Base 12
Skull Base Neoplasms 44

Classifications:



External Ids:

Disease Ontology 12 DOID:3842
MeSH 44 D019292
NCIt 50 C4676
UMLS 70 C0376527

Summaries for Skull Base Cancer

MalaCards based summary : Skull Base Cancer, also known as tumors of skull base, is related to secretory meningioma and meningioma, familial. An important gene associated with Skull Base Cancer is SERPINA3 (Serpin Family A Member 3). The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Skull Base Cancer

Diseases related to Skull Base Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 secretory meningioma 29.5 TRAF7 SMARCE1 SERPINA3 NF2 KLF4
2 meningioma, familial 28.7 TRAF7 SST SMARCE1 SERPINA3 PGR NF2
3 pediatric meningioma 10.3 TRAF7 NF2
4 intraventricular meningioma 10.3 TRAF7 NF2
5 psammomatous meningioma 10.3 TRAF7 NF2
6 meninges hemangiopericytoma 10.3 TRAF7 NF2
7 intraneural perineurioma 10.3 TRAF7 NF2
8 proliferative type fibrocystic change of breast 10.3 SERPINA3 EXTL1
9 non-proliferative fibrocystic change of the breast 10.3 SERPINA3 EXTL1
10 chordoid meningioma 10.3 TRAF7 NF2
11 rhabdoid meningioma 10.3 TRAF7 NF2
12 fibrous meningioma 10.2 TRAF7 NF2
13 foramen magnum meningioma 10.2 SPATA31A1 NF2
14 type c thymoma 10.2 SST SERPINA3
15 olfactory neuroblastoma 10.2
16 non-langerhans-cell histiocytosis 10.2 SST SERPINA3
17 rare tumor 10.2 SST NF2
18 mn1 c-terminal truncation syndrome 10.2 SMARCE1 NF2
19 pancreatoblastoma 10.2 SST SERPINA3
20 pancreatic endocrine carcinoma 10.2 SST SERPINA3
21 spinal cancer 10.1 SMARCE1 NF2
22 congenital epulis 10.1 SERPINA3 PGR
23 frontal convexity meningioma 10.1 TRAF7 NF2 KLF4
24 mucosal melanoma 10.1
25 bell's palsy 10.1
26 facial paralysis 10.1
27 cerebrospinal fluid leak 10.1
28 epulis 10.1 SERPINA3 PGR
29 lung meningioma 10.1 PGR NF2
30 pleomorphic lipoma 10.1 SERPINA3 PGR
31 breast malignant phyllodes tumor 10.1 SERPINA3 PGR
32 polyp of corpus uteri 10.1 PGR NF2
33 apocrine adenocarcinoma 10.1 SERPINA3 PGR
34 epithelioid leiomyosarcoma 10.1 SERPINA3 PGR
35 ovarian endometrial cancer 10.1 SERPINA3 PGR
36 chordoid glioma 10.1 PGR NF2
37 peripheral nerve schwannoma 10.1 SMARCE1 SERPINA3 NF2
38 central nervous system benign neoplasm 10.1 SERPINA3 NF2
39 sweat gland benign neoplasm 10.1 SERPINA3 PGR
40 rhabdoid cancer 10.0 SMARCE1 SERPINA3 NF2
41 angiomatous meningioma 10.0 TRAF7 SMARCE1 NF2
42 adenosarcoma 10.0 SERPINA3 PGR
43 progressive relapsing multiple sclerosis 10.0 SERPINA3 PGR
44 sweat gland disease 10.0 SERPINA3 PGR
45 thoracic benign neoplasm 10.0 SERPINA3 PGR
46 breast benign neoplasm 10.0 SERPINA3 PGR
47 mixed cell type cancer 10.0 SERPINA3 PGR
48 prostatic hypertrophy 10.0 SERPINA3 PGR
49 smooth muscle tumor 10.0 SERPINA3 PGR
50 chondrosarcoma 10.0

Graphical network of the top 20 diseases related to Skull Base Cancer:



Diseases related to Skull Base Cancer

Symptoms & Phenotypes for Skull Base Cancer

Drugs & Therapeutics for Skull Base Cancer

Drugs for Skull Base Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Serial Magnetic Resonance Imaging of Longitudinal Radiotherapy-Attributable Normal Tissue Injury Recruiting NCT04265430 Phase 4
2 Skull Base Reconstruction After Endonasal Cranio-endoscopic Resection Using Autologus Grafts Unknown status NCT03448614
3 Proposal for Intraoperative Administration of Intravenous Indocyanine Green to Evaluate Position of the Optic Canal, Position of the Internal Carotid Arteries, Tumor Vascularization, and Vessel Encasement in Endoscopic Endonasal Cranial Base Surgery Completed NCT03072186
4 Effects on the Awakening With Laryngeal Mask vs Endotracheal Tube in Endoscopic Endonasal Transsphenoidal Base Surgery Completed NCT02988804
5 Proposal for Intraoperative Administration of Intravenous Indocyanine Green to Evaluate Sphenopalatine Artery Location and Patency in Harvesting and Positioning a Pedicled Nasoseptal Mucosal Flap in Endoscopic Endonasal Cranial Base Surgery Completed NCT02117310 indocyanine green
6 Pilot Study of In-Room PET in Proton Radiation Therapy Completed NCT01228448
7 Evaluation of Acupuncture Effects for Complications After Surgery of Cerebellopontine Angle Tumor in Skull Base Recruiting NCT04249921
8 Molecular and Cellular Characterization of Skull Base Tumors Recruiting NCT03759717
9 Prospective Observational Trial of the Impact of Radiation Dose on Brain Morphology, Volumetric Changes, Endocrine Function, and Neurocognitive Function Following Cranial Radiation Therapy in Children With Brain and Skull Base Tumors. Recruiting NCT03972514
10 Assessment of Predicted LET and Dosimetry in Relation to White Matter Changes in Pediatric Patients Following Proton Therapy for Primary Central Nervous System and Base of Skull Malignancies: A Pilot Study Recruiting NCT04296617
11 Feasibility of Auditory Nerve Test System for Optimization of Simultaneous Translabyrinthine Vestibular Schwannoma Resection With Cochlear Implantation Active, not recruiting NCT04241679
12 The Utility of Indocyanine Green Fluorescence in Endoscopic Sinonasal and Skull Base Surgery - A Prospective Case-Series and Feasibility Study Not yet recruiting NCT04374448

Search NIH Clinical Center for Skull Base Cancer

Cochrane evidence based reviews: skull base neoplasms

Genetic Tests for Skull Base Cancer

Anatomical Context for Skull Base Cancer

MalaCards organs/tissues related to Skull Base Cancer:

40
Brain

Publications for Skull Base Cancer

Articles related to Skull Base Cancer:

(show all 29)
# Title Authors PMID Year
1
The importance of flaps in reconstruction of locoregionally advanced lateral skull-base cancer defects: a tertiary otorhinolaryngology referral centre experience. 61
33735947 2021
2
Anatomical variations of clivus: a descriptive anatomical study. 61
33483831 2021
3
Managing care for patients with sinonasal and anterior skull base cancers during the COVID-19 pandemic. 61
32415882 2020
4
[A new method: lower trapezius island myocutaneous flap to repair surgical defect in lateral skull base cancer after radiotherapy]. 61
32306644 2020
5
Mental Health Disorders Associated with Sinonasal and Skull Base Malignancies: A Large Cohort Study. 61
32206538 2020
6
Facial Nerve Paralysis after Onyx Embolization of a Jugular Paraganglioma: A Case Report with a Long-Term Follow Up. 61
29518926 2018
7
Tumour stem cells in meningioma: A review. 61
29113852 2018
8
Cognitive function and patient-reported memory problems after radiotherapy for cancers at the skull base: A cross-sectional survivorship study using the Telephone Interview for Cognitive Status and the MD Anderson Symptom Inventory-Head and Neck Module. 61
28763137 2017
9
The cost of major head and neck cancer surgery. 61
28494483 2017
10
The Role of Chemotherapy in the Management of Sinonasal and Ventral Skull Base Malignancies. 61
28160997 2017
11
Impact of Endoscopic Indocyanine Green Fluorescence Imaging on Superselective Intra-arterial Chemotherapy for Recurrent Cancer of the Skull Base. 61
27354602 2016
12
Multiportal combined transnasal transoral transpharyngeal endoscopic approach for selected skull base cancers. 61
26855345 2016
13
Management of lateral skull base cancer: United Kingdom National Multidisciplinary Guidelines. 61
27841125 2016
14
Follow-up after treatment for head and neck cancer: United Kingdom National Multidisciplinary Guidelines. 61
27841136 2016
15
Brain Herniation After Endoscopic Transnasal Resection of Anterior Skull Base Malignancies. 61
26110997 2015
16
Late toxicity of proton beam therapy for patients with the nasal cavity, para-nasal sinuses, or involving the skull base malignancy: importance of long-term follow-up. 61
25135461 2015
17
Improvement in survival during the past 4 decades among patients with anterior skull base cancer. 61
22076799 2012
18
On-board imaging validation of optically guided stereotactic radiosurgery positioning system for conventionally fractionated radiotherapy for paranasal sinus and skull base cancer. 61
21543166 2011
19
Nutrition management of patients with malignancies of the head and neck. 61
21621700 2011
20
Heavy ion radiotherapy during pregnancy. 61
20493478 2010
21
The role of palliative radiosurgery when cancer invades the cavernous sinus. 61
18692328 2009
22
Minimally invasive endoscopic pericranial flap: a new method for endonasal skull base reconstruction. 61
19117286 2009
23
Evaluation of quality of life and psychiatric morbidity in patients with malignant tumours of the skull base. 61
17059620 2006
24
Cranial base strategies for resection of craniopharyngioma in children. 61
16048295 2005
25
Malignant tumors of the anterior skull base. 61
15153838 2004
26
Intraoperative radiotherapy for head and neck and skull base cancer. 61
12599289 2003
27
Medial antebrachial cutaneous nerve: a new donor graft for repair of facial nerve defects at the skull base. 61
9261006 1997
28
Postoperative irradiation of patients with malignant tumors of skull base. 61
8667987 1996
29
Intraoperative radiotherapy of skull base cancer. 61
1851521 1991

Variations for Skull Base Cancer

Expression for Skull Base Cancer

Search GEO for disease gene expression data for Skull Base Cancer.

Pathways for Skull Base Cancer

GO Terms for Skull Base Cancer

Sources for Skull Base Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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