MCID: SKL005
MIFTS: 27

Skull Base Meningioma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Skull Base Meningioma

MalaCards integrated aliases for Skull Base Meningioma:

Name: Skull Base Meningioma 12 15 73
Meningioma of the Skull Base 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4437
NCIt 50 C5272
UMLS 73 C1335976

Summaries for Skull Base Meningioma

MalaCards based summary : Skull Base Meningioma, also known as meningioma of the skull base, is related to multiple skull base meningioma and otitis media, and has symptoms including headache and seizures. An important gene associated with Skull Base Meningioma is WT1 (Wilms Tumor 1). The drug Edotreotide has been mentioned in the context of this disorder. Affiliated tissues include bone, pituitary and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Skull Base Meningioma

Diseases related to Skull Base Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 multiple skull base meningioma 12.4
2 otitis media 9.9
3 benign meningioma 9.8
4 wilms tumor 5 9.8
5 wilms tumor 6 9.8
6 hydrocephalus 9.8
7 ischemic optic neuropathy 9.8
8 adenoiditis 9.8
9 adenoid cystic carcinoma 9.8
10 abducens nerve disease 9.8
11 epilepsy 9.8
12 optic nerve disease 9.8
13 cerebritis 9.8
14 neuropathy 9.8
15 meningitis 9.8
16 anaplastic ependymoma 9.8
17 carcinoid syndrome 9.8
18 ependymoma 9.8
19 ocular neuromyotonia 9.8
20 pseudobulbar affect 9.8
21 intracranial sinus thrombosis 9.0 BLVRA NT5C3A
22 petroclival meningioma 8.6 BLVRA KRT83 NT5C3A
23 skull base neoplasm 7.4 AKAP9 BLVRA CCDC174 KRT83 NT5C3A

Graphical network of the top 20 diseases related to Skull Base Meningioma:



Diseases related to Skull Base Meningioma

Symptoms & Phenotypes for Skull Base Meningioma

UMLS symptoms related to Skull Base Meningioma:


headache, seizures

GenomeRNAi Phenotypes related to Skull Base Meningioma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.62 WT1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.62 NT5C3A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.62 NT5C3A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.62 WT1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.62 NT5C3A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.62 NT5C3A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.62 NT5C3A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.62 NT5C3A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.62 WT1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.62 NT5C3A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.62 NT5C3A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.62 WT1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.62 WT1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.62 WT1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.62 WT1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.62 WT1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.62 NT5C3A WT1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.62 WT1 NT5C3A

Drugs & Therapeutics for Skull Base Meningioma

Drugs for Skull Base Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Edotreotide Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Enhancement of Neurocognitive Functions by Hippocampal Sparing Radiotherapy Recruiting NCT01849484 Phase 2
2 Hyperbaric Oxygen Therapy Can Improve Neurological State Post Meningioma Removal Surgery Unknown status NCT02084927 Phase 1
3 Comparison of Proton and Carbon Ion Radiotherapy With Advanced Photon Radiotherapy in Skull Base Meningiomas: The PINOCCHIO Trial. Not yet recruiting NCT01795300 Not Applicable

Search NIH Clinical Center for Skull Base Meningioma

Genetic Tests for Skull Base Meningioma

Anatomical Context for Skull Base Meningioma

MalaCards organs/tissues related to Skull Base Meningioma:

41
Bone, Pituitary, Brain, T Cells

Publications for Skull Base Meningioma

Articles related to Skull Base Meningioma:

(show top 50) (show all 52)
# Title Authors Year
1
Pseudobulbar Affect Due to Skull Base Meningioma Resolving After Temporal Lobectomy for Epilepsy. ( 29747704 )
2018
2
Spontaneous regression of a large skull base meningioma: case report. ( 29334772 )
2018
3
Influence of <sup>68</sup>Ga-DOTATOC on sparing of normal tissue for radiation therapy of skull base meningioma: differential impact of photon and proton radiotherapy. ( 29606149 )
2018
4
Multivariate risk factor analysis and literature review of postoperative deterioration in Karnofsky Performance Scale score in elderly patients with skull base meningioma. ( 29606047 )
2018
5
Introduction. Skull base meningioma treatment strategies. ( 29606055 )
2018
6
Skull base versus non-skull base meningioma surgery in the elderly. ( 29978438 )
2018
7
One-step CAD/CAM titanium cranioplasty after drilling template-assisted resection of intraosseous skull base meningioma: technical note. ( 28074281 )
2017
8
Letter to the Editor. Neuropsychological impairment and quality of life after skull base meningioma resection: size and location matter. ( 28960157 )
2017
9
Frozen Section Can &amp;quot;Sharpen&amp;quot; or &amp;quot;Sand Off&amp;quot; the Surgeon's Knife: 2 Case Illustrations with Skull Base Meningioma Mimics. ( 28842226 )
2017
10
The extended, transnasal, transsphenoidal approach for anterior skull base meningioma: considerations in patient selection. ( 28689230 )
2017
11
Evaluation of Venous Drainage Patterns for Skull Base Meningioma Surgery. ( 28579577 )
2017
12
Lessons learned from reirradiation of recurrent skull base meningioma: A case report and review of the literature. ( 28740909 )
2017
13
Volume-staged gamma knife surgery for the treatment of large skull base meningioma surrounding the optical apparatus: A snowman-shape design. ( 28751167 )
2017
14
The Extended Subfrontal and Fronto-Orbito-Zygomatic Approach in Skull Base Meningioma Surgery: Clinical, Radiologic, and Cosmetic Outcome. ( 26825741 )
2016
15
Microsurgical resection of skull base meningioma-expanding the operative corridor. ( 27439458 )
2016
16
Rectal carcinoid tumor metastasis to a skull base meningioma. ( 26825133 )
2016
17
Radiation-induced anaplastic ependymoma mimicking a skull base meningioma: A case report. ( 26893630 )
2016
18
Case report: Epicranial pain after radiotherapy for skull base meningioma - the first symptomatic epicrania fugax? ( 27036640 )
2016
19
Safety and efficacy of medium-sized particle embolisation for skull-base meningioma. ( 26791376 )
2016
20
A rare case of atypical skull base meningioma with perineural spread. ( 27200171 )
2015
21
Ocular Neuromyotonia Noted after Recent Botulinum Toxin Injection for Sixth Nerve Palsy Following Resection of a Posterior Fossa Skull Base Meningioma. ( 27928330 )
2015
22
Minimal invasive trans-eyelid approach to anterior and middle skull base meningioma: a preliminary study of Shanghai Huashan hospital. ( 25550905 )
2014
23
Adoptive transfer of genetically modified Wilms' tumor 1-specific T cells in a novel malignant skull base meningioma model. ( 23460320 )
2013
24
5-Aminolevulinic Acid and (18)F-FET-PET as Metabolic Imaging Tools for Surgery of a Recurrent Skull Base Meningioma. ( 24436914 )
2013
25
A rare case of large skull base meningioma mimicking otitis media with effusion. ( 24454401 )
2013
26
The 'double pituitary hot spot' sign of skull base meningioma on gallium-68-labelled somatostatin analogue PET. ( 24283556 )
2013
27
A Comparative Study of Stereotactic Radiosurgery, Hypofractionated, and Fractionated Stereotactic Radiotherapy in the Treatment of Skull Base Meningioma. ( 23241504 )
2012
28
Delayed vasospasm after removal of a skull base meningioma. ( 21104584 )
2012
29
Skull base meningiomas mimicking otitis media. ( 22494527 )
2012
30
What is the best approach to resect an anterior midline skull base meningioma in 2011? Microsurgical transcranial, endonasal endoscopic, or minimal access cranial? ( 22120227 )
2012
31
An unusual nasal polyp: skull base meningioma with extracranial extension into the nasal cavity. ( 22241410 )
2012
32
Predicting postoperative hydrocephalus in 227 patients with skull base meningioma. ( 21529180 )
2011
33
Subacute brainstem necrosis: a complication of stereotactic radiotherapy for skull base meningioma. ( 21150684 )
2011
34
Analysis of factors affecting the long-term functional outcome of patients with skull base meningioma. ( 21565513 )
2011
35
Skull base meningioma - comparison of intensity-modulated radiotherapy planning techniques using the moduleaf micro-multileaf collimator and helical tomotherapy. ( 20171061 )
2010
36
The role of radical microsurgical resection in multimodal treatment for skull base meningioma. ( 20225926 )
2010
37
Balloon-assisted embolization of skull base meningioma with liquid embolic agent. ( 19361255 )
2010
38
Stereotactic radiosurgery for skull base meningioma. ( 19855141 )
2009
39
ABC Surgical Risk Scale for skull base meningioma: a new scoring system for predicting the extent of tumor removal and neurological outcome. Clinical article. ( 19119879 )
2009
40
Gamma Knife radiosurgery for skull base meningioma: long-term results of low-dose treatment. ( 18976068 )
2008
41
Patterns of skull base meningioma progression after failed radiosurgery. ( 17236485 )
2007
42
Impact of anomalous origin of the ophthalmic artery from the middle meningeal artery on selection of surgical approach to skull base meningioma. ( 17961750 )
2007
43
A canine case of skull base meningioma treated with hydroxyurea. ( 18176033 )
2007
44
111Indium-octreotide brain scintigraphy: a prognostic factor in skull base meningiomas treated with gamma knife radiosurgery. ( 15195001 )
2004
45
Postoperative reversal of complete (monocular) blindness in skull base meningioma: case report. ( 12619789 )
2003
46
Improvement in cognitive function after radical excision of an anterior skull base meningioma--a report of 2 cases. ( 12763352 )
2003
47
Skull base meningioma: delayed extracranial presentation. ( 17167609 )
2001
48
Delayed ischemic optic neuropathy after surgery on skull base meningiomas successfully treated with nimodipine and rheological therapy: report of two cases. ( 17171149 )
2000
49
Multiple skull base meningioma: case report. ( 10086491 )
1999
50
Dumbbell tumor of the anterior skull base. Meningioma? No, adenoid cystic carcinoma! ( 9842875 )
1998

Variations for Skull Base Meningioma

Expression for Skull Base Meningioma

Search GEO for disease gene expression data for Skull Base Meningioma.

Pathways for Skull Base Meningioma

GO Terms for Skull Base Meningioma

Cellular components related to Skull Base Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.02 AKAP9 BLVRA KRT83 NT5C3A WT1

Biological processes related to Skull Base Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to cAMP GO:0071320 8.62 AKAP9 WT1

Sources for Skull Base Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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