MCID: SKL005
MIFTS: 35

Skull Base Meningioma

Categories: Bone diseases, Cancer diseases
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Aliases & Classifications for Skull Base Meningioma

MalaCards integrated aliases for Skull Base Meningioma:

Name: Skull Base Meningioma 11 14 71
Meningioma of the Skull Base 11

Classifications:



External Ids:

Disease Ontology 11 DOID:4437
NCIt 49 C5272
UMLS 71 C1335976

Summaries for Skull Base Meningioma

MalaCards based summary: Skull Base Meningioma, also known as meningioma of the skull base, is related to carcinoid tumors, intestinal and foramen magnum meningioma, and has symptoms including headache and seizures. An important gene associated with Skull Base Meningioma is TRAF7 (TNF Receptor Associated Factor 7), and among its related pathways/superpathways are Signal Transduction and Malignant pleural mesothelioma. Affiliated tissues include bone, pituitary and brain, and related phenotypes are Increased proliferation and nervous system

Related Diseases for Skull Base Meningioma

Diseases in the Skull Base Meningioma family:

Multiple Skull Base Meningioma

Diseases related to Skull Base Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 carcinoid tumors, intestinal 30.5 SSTR2 SST
2 foramen magnum meningioma 30.3 TRAF7 POLR2A NF2
3 neurofibromatosis, type i 30.1 SST NF2 AKT1
4 low grade glioma 30.0 TERT SERPINA3 AKT1
5 benign meningioma 30.0 TRAF7 TERT POLR2A NF2 KLF4
6 anaplastic ependymoma 29.9 SMARCB1 NF2
7 adenoid cystic carcinoma 29.7 SMARCE1 SERPINA3 PIK3CA AKT1
8 neurilemmoma 29.7 SMARCB1 SERPINA3 NF2 AKT1
9 olfactory groove meningioma 29.7 TRAF7 SMARCE1 SMARCB1 POLR2A NF2 KLF4
10 wilms tumor 1 29.6 TERT SMARCB1 SERPINA3 AKT1
11 brain cancer 29.3 TERT SMARCB1 PIK3CA NF2 AKT1
12 clear cell meningioma 29.2 TRAF7 TERT SMARCE1 SMARCB1 POLR2A NF2
13 intracranial meningioma 29.1 TRAF7 SSTR2 SST SMARCE1 SMARCB1 POLR2A
14 meningothelial meningioma 28.7 TRAF7 TERT SSTR2 SMARCE1 SMARCB1 SERPINA3
15 meningioma, familial 28.6 TRAF7 TERT SSTR2 SST SMO SMARCE1
16 multiple skull base meningioma 11.4
17 tuberculum sellae meningioma 10.3 TRAF7 NF2
18 sella turcica neoplasm 10.3 TRAF7 NF2
19 intraneural perineurioma 10.3 TRAF7 NF2
20 cerebellopontine angle meningioma 10.3 SMARCE1 NF2
21 factor vii deficiency 10.2
22 central diabetes insipidus 10.2
23 diabetes insipidus 10.2
24 sphenoorbital meningioma 10.2 TRAF7 SMARCE1 NF2
25 cerebral meningioma 10.2 TRAF7 SMARCE1 NF2
26 tricuspid valve stenosis 10.2 SST SERPINA3
27 endocrine pancreas disease 10.2 SSTR2 SST
28 papillon-lefevre syndrome 10.2
29 kearns-sayre syndrome 10.2
30 aspergillosis 10.2
31 ptosis 10.2
32 hydrocephalus 10.2
33 obstructive hydrocephalus 10.2
34 hypopituitarism 10.2
35 cerebrospinal fluid leak 10.2
36 gastrointestinal neuroendocrine tumor 10.1 SSTR2 SST
37 full schwannomatosis 10.1 SMARCB1 NF2
38 posterior pituitary gland neoplasm 10.1 SMARCB1 NF2
39 apocrine adenocarcinoma 10.1 SERPINA3 PIK3CA
40 carney complex variant 10.1 SST SERPINA3 NF2
41 pineal region meningioma 10.1 SMARCB1 NF2
42 plexiform schwannoma 10.1 SMARCB1 NF2
43 schwannomatosis 1 10.1 SMARCB1 NF2
44 pulmonary neuroendocrine tumor 10.1 SSTR2 SST
45 cerebellopontine angle tumor 10.1 SMARCB1 NF2
46 chondrosarcoma 10.1
47 intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 10.1
48 alopecia 10.1
49 cellular schwannoma 10.1 SMARCB1 NF2
50 esophageal neuroendocrine tumor 10.1 SSTR2 SST

Graphical network of the top 20 diseases related to Skull Base Meningioma:



Diseases related to Skull Base Meningioma

Symptoms & Phenotypes for Skull Base Meningioma

UMLS symptoms related to Skull Base Meningioma:


headache; seizures

GenomeRNAi Phenotypes related to Skull Base Meningioma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Skull Base Meningioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.96 AKT1 KLF4 NF2 PIK3CA POLR2A SMARCB1
2 neoplasm MP:0002006 9.87 AKT1 KLF4 NF2 PIK3CA POLR2A SMARCB1
3 digestive/alimentary MP:0005381 9.81 KLF4 NF2 PIK3CA POLR2A SMARCB1 SMO
4 immune system MP:0005387 9.7 AKT1 KLF4 NF2 PIK3CA POLR2A SERPINA3
5 integument MP:0010771 9.28 AKT1 KLF4 NF2 PIK3CA POLR2A SERPINA3

Drugs & Therapeutics for Skull Base Meningioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pre and Post-Operative Cognitive Status in Patients Undergoing Surgery for Resection of Meningioma Associated With the Frontal and Temporal Lobes Recruiting NCT04635657
2 Randomized Comparison of Proton and Carbon Ion Radiotherapy With Advanced Photon Radiotherapy in Skull Base Meningiomas: The PINOCCHIO Trial. Withdrawn NCT01795300

Search NIH Clinical Center for Skull Base Meningioma

Genetic Tests for Skull Base Meningioma

Anatomical Context for Skull Base Meningioma

Organs/tissues related to Skull Base Meningioma:

MalaCards : Bone, Pituitary, Brain, T Cells, Prostate, Lung

Publications for Skull Base Meningioma

Articles related to Skull Base Meningioma:

(show top 50) (show all 200)
# Title Authors PMID Year
1
Machine Learning Models for Predicting Postoperative Outcomes following Skull Base Meningioma Surgery. 62
36393884 2022
2
Predictive Power of MIB-1 vs. Mitotic Count on Progression-Free Survival in Skull-Base Meningioma. 62
36230518 2022
3
Low-Dose Acetylsalicylic Acid Treatment in Non-Skull-Base Meningiomas: Impact on Tumor Proliferation and Seizure Burden. 62
36077817 2022
4
Adjuvant Radiotherapy in Grade II, Atypical Meningioma of the Skull Base. 62
35903662 2022
5
Perioperative Complication Profile of Skull Base Meningioma Resection in Older versus Younger Adult Patients. 62
35903656 2022
6
Gross Total Resection of a Recurrent in-and-around Cavernous Sinus Meningioma through a Combined Transcavernous Anterior and Middle Infratemporal Fossa Approach with Extracranial-Intracranial Bypass. 62
36068904 2022
7
Gross Total Resection of a Recurrent Cavernous Sinus Meningioma through a Combined Transzygomatic Transcavernous and Extended Middle Fossa Approach with Cavernous Carotid Denudation. 62
36068891 2022
8
Metastatic grade 1 meningioma lacking genetic abnormalities commonly associated with bad prognosis. 62
36067609 2022
9
Resection of Skull Base Meningioma With Extensive Extracranial Extension: 2-Dimensional Operative Video. 62
35726935 2022
10
Early Detection and Management of Venous Thrombosis in Skull Base Surgery: Role of Routine Doppler Ultrasound Monitoring. 62
35383697 2022
11
Skull Base Meningiomas in Patients with Neurofibromatosis Type 2: An International Multicenter Study Evaluating Stereotactic Radiosurgery. 62
35832959 2022
12
Midline Skull Base Meningiomas: Transcranial and Endonasal Perspectives. 62
35740543 2022
13
Case Series of Skull Base Meningioma Resection in the Octogenarian Population. 62
35832965 2022
14
Residual Tumor Volume and Tumor Progression after Subtotal Resection and Observation of WHO Grade I Skull Base Meningiomas. 62
35832958 2022
15
Long-term health-related quality of life and neurocognitive functioning after treatment in skull base meningioma patients. 62
34598137 2022
16
Predicting High-Value Care Outcomes After Surgery for Non-Skull Base Meningiomas. 62
34896348 2022
17
The Patient's Perspective on Proton Radiotherapy of Skull Base Meningioma: A Retrospective Cross-Sectional Survey. 62
35992835 2022
18
Surgical outcomes and longitudinal quality of life after endoscopic endonasal surgery for anterior skull base meningioma. 62
35171831 2022
19
Teaching NeuroImage: Isolated Unilateral Hypoglossal Nerve Palsy due to Skull Base Meningioma. 62
34031197 2021
20
Awake Craniotomy for Resection of Intracranial Meningioma: First Case Series From a Low- and Middle-Income Country. 62
34790471 2021
21
Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy. 62
34917780 2021
22
Two Birds with One Stone: Skull Base Meningioma and Jugulotympanic Paragangliomas with Somatostatin Receptor Positron Emission Tomography. 62
34574010 2021
23
Occurrence of pituitary hormone deficits in relation to both pituitary and hypothalamic doses after radiotherapy for skull base meningioma. 62
34028837 2021
24
Short diameter may be a useful simple indicator of the tumor response in skull base meningiomas after conventionally fractionated stereotactic radiotherapy. 62
33569622 2021
25
Concomitant Embolization and Microsurgical Resection of a Giant, Hypervascular Skull Base Meningioma: 2-Dimensional Operative Video. 62
33930164 2021
26
Clinical Outcome and Risk Factors of Red Blood Cell Transfusion in Patients Undergoing Elective Primary Meningioma Resection. 62
34298814 2021
27
Commentary: Concomitant Embolization and Microsurgical Resection of a Giant, Hypervascular Skull Base Meningioma: 2-Dimensional Operative Video. 62
34015826 2021
28
Predicting High-Value Care Outcomes After Surgery for Skull Base Meningiomas. 62
33567369 2021
29
Relationship between Pathological Characteristics and Radiological Findings on Perfusion MR Imaging of Meningioma. 62
33504729 2021
30
Trends in cerebrospinal fluid leak rates following the extended endoscopic endonasal approach for anterior skull base meningioma: a meta-analysis over the last 20 years. 62
33188605 2021
31
Predictors of Survival in Subtotally Resected WHO Grade I Skull Base Meningiomas. 62
33810089 2021
32
High Mib-1-score correlates with new cranial nerve deficits after surgery for frontal skull base meningioma. 62
31834543 2021
33
Outcomes from treatment of asymptomatic skull base meningioma with stereotactic radiosurgery. 62
33211178 2021
34
[Changes in treatment paradigm for neurosurgical patients in the era of stereotactic irradiation. By the 15th anniversary of the Neuroradiosurgery in Russia]. 62
34714003 2021
35
Clinical presentation of neuroendocrine cancer metastasis to an anterior clinoid process meningioma invading superior orbital fissure. A case report. 62
34628798 2021
36
A Probability-Based Investigation on the Setup Robustness of Pencil-beam Proton Radiation Therapy for Skull-Base Meningioma. 62
33604414 2021
37
The positive effects of surgery on symptomatic stereotactic radiation-induced peritumoral brain edema: A report of three cases. 62
34345498 2021
38
Oscillopsia following orbitotomy for intracranial tumor resection. 62
34621574 2021
39
Correction to: Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis. 62
33317569 2020
40
Rare Tumor-to-Tumor Metastases Involving Lung Adenocarcinoma to Petroclival Meningiomas. 62
32730974 2020
41
Significance of the simultaneous combined transcranial and endoscopic endonasal approach for prevention of postoperative CSF leak after surgery for lateral skull base meningioma. 62
33222918 2020
42
Minimally invasive surgical treatment of intracranial meningiomas in elderly patients (≥ 65 years): outcomes, readmissions, and tumor control. 62
33002879 2020
43
An Aggressive Extension of Dumbbell-Type Pediatric Skull Base Meningioma: A Case Report with Review of the Literature. 62
32371076 2020
44
Dosimetric Comparison of Hypofractionated Multi-Beam Intensity-Modulated Radiation Therapy and Volumetric Modulated Arc Therapy With Flattened Beam and Flattening-Filter-Free Beam for Skull Base Meningioma Adjacent to Optic Pathways. 62
32699688 2020
45
Spontaneous regression of a large skull base meningioma: case report. 62
29334772 2020
46
The utility of 3-dimensional-printed models for skull base meningioma surgery. 62
32355814 2020
47
Occipital to Angular Artery Bypass for Post-irradiation Ischemia: 3-Dimensional Operative Video. 62
31173139 2020
48
Endoscopic technology and repair techniques. 62
32586493 2020
49
Ventriculoperitoneal shunt placement with ultrasound guidance and laparoscopic assistance: 2-dimensional instructional video. 62
32844047 2020
50
Parasellar meningioma presenting by stroke and bilateral occlusion of the internal carotid arteries: A case report. 62
32047631 2020

Variations for Skull Base Meningioma

Expression for Skull Base Meningioma

Search GEO for disease gene expression data for Skull Base Meningioma.

Pathways for Skull Base Meningioma

Pathways related to Skull Base Meningioma according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1 13.42 TERT SSTR2 SST SMO POLR2A PIK3CA
2 12.47 TERT PIK3CA NF2 AKT1
3
Show member pathways
11.75 TERT PIK3CA AKT1
4 11.68 AKT1 KLF4 PIK3CA
5 11.36 TERT PIK3CA AKT1
6 11.23 SMARCE1 PIK3CA AKT1
7 10.96 PIK3CA AKT1
8 10.95 PIK3CA AKT1
9 10.95 PIK3CA AKT1
10 10.92 PIK3CA AKT1
11 10.89 PIK3CA AKT1
12
Show member pathways
10.89 SMO PIK3CA AKT1
13
Show member pathways
10.87 TERT PIK3CA AKT1
14 10.83 PIK3CA AKT1
15 10.79 PIK3CA AKT1
16 10.78 TERT AKT1
17 10.77 PIK3CA AKT1
18
Show member pathways
10.66 SMO SMARCE1 SMARCB1
19 10.65 SMARCE1 SMARCB1
20 10.51 PIK3CA AKT1
21 10.3 PIK3CA NF2 AKT1

GO Terms for Skull Base Meningioma

Cellular components related to Skull Base Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bBAF complex GO:0140092 8.92 SMARCE1 SMARCB1

Biological processes related to Skull Base Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell population proliferation GO:0008285 9.96 SSTR2 SST SMARCB1 NF2 KLF4
2 negative regulation of gene expression GO:0010629 9.65 TERT SMO PIK3CA KLF4 AKT1
3 positive regulation of cell differentiation GO:0045597 9.63 SMARCE1 SMARCB1 NF2
4 positive regulation of organ growth GO:0046622 9.62 SMO AKT1
5 RNA-templated transcription GO:0001172 8.8 TERT POLR2A

Molecular functions related to Skull Base Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA-dependent RNA polymerase activity GO:0003968 8.8 TERT POLR2A

Sources for Skull Base Meningioma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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