Sleep Apnea

Categories: Mental diseases, Neuronal diseases, Respiratory diseases
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Aliases & Classifications for Sleep Apnea

MalaCards integrated aliases for Sleep Apnea:

Name: Sleep Apnea 11 52 28 5 41 14 63 16 75
Sleep Apnea Syndromes 43 71


External Ids:

Disease Ontology 11 DOID:0050847
ICD9CM 34 780.57
MeSH 43 D012891
NCIt 49 C26884
SNOMED-CT 68 206750008
ICD10 31 G47.3
UMLS 71 C0037315

Summaries for Sleep Apnea

NINDS: 52 Sleep apnea is a common sleep disorder characterized by brief interruptions of breathing during sleep.  These episodes usually last 10 seconds or more and occur repeatedly throughout the night.  People with sleep apnea will partially awaken as they struggle to breathe, but in the morning they will not be aware of the disturbances in their sleep.  The most common type of sleep apnea is obstructive sleep apnea (OSA), caused by relaxation of soft tissue in the back of the throat that blocks the passage of air.  Central sleep apnea (CSA) is caused by irregularities in the brain’s normal signals to breathe.  Most people with sleep apnea will have a combination of both types.  The hallmark symptom of the disorder is excessive daytime sleepiness. Additional symptoms of sleep apnea include restless sleep, loud snoring (with periods of silence followed by gasps), falling asleep during the day, morning headaches, trouble concentrating, irritability, forgetfulness, mood or behavior changes, anxiety, and depression.  Not everyone who has these symptoms will have sleep apnea, but it is recommended that people who are experiencing even a few of these symptoms visit their doctor for evaluation.  Sleep apnea is more likely to occur in men than women, and in people who are overweight or obese.

MalaCards based summary: Sleep Apnea, also known as sleep apnea syndromes, is related to central sleep apnea and obesity-hypoventilation syndrome, and has symptoms including tremor, back pain and dyspnea. An important gene associated with Sleep Apnea is AHDC1 (AT-Hook DNA Binding Motif Containing 1), and among its related pathways/superpathways are Signal Transduction and p70S6K Signaling. The drugs Montelukast and Opium have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and tongue, and related phenotypes are homeostasis/metabolism and nervous system

MedlinePlus: 41 Sleep apnea is a common disorder that causes your breathing to stop or get very shallow. Breathing pauses can last from a few seconds to minutes. They may occur 30 times or more an hour. The most common type is obstructive sleep apnea. It causes your airway to collapse or become blocked during sleep. Normal breathing starts again with a snort or choking sound. People with sleep apnea often snore loudly. However, not everyone who snores has sleep apnea. You are more at risk for sleep apnea if you are overweight, male, or have a family history or small airways. Children with enlarged tonsils or adenoids may also get it. Doctors diagnose sleep apnea based on medical and family histories, a physical exam, and sleep study results. When your sleep is interrupted throughout the night, you can be drowsy during the day. People with sleep apnea are at higher risk for car crashes, work-related accidents, and other medical problems. If you have it, it is important to get treatment. Lifestyle changes, mouthpieces, surgery, and breathing devices can treat sleep apnea in many people. NIH: National Heart, Lung, and Blood Institute

PubMed Health : 63 Sleep apnea: Sleep apnea (AP-ne-ah) is a common disorder in which you have one or more pauses in breathing or shallow breaths while you sleep. Breathing pauses can last from a few seconds to minutes. They may occur 30 times or more an hour. Typically, normal breathing then starts again, sometimes with a loud snort or choking sound. Sleep apnea usually is a chronic (ongoing) condition that disrupts your sleep. When your breathing pauses or becomes shallow, you’ll often move out of deep sleep and into light sleep. As a result, the quality of your sleep is poor, which makes you tired during the day. Sleep apnea is a leading cause of excessive daytime sleepiness.

Disease Ontology: 11 A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep.

Wikipedia: 75 Sleep apnea, also spelled sleep apnoea, is a sleep disorder in which pauses in breathing or periods of... more...

Related Diseases for Sleep Apnea

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1701)
# Related Disease Score Top Affiliating Genes
1 central sleep apnea 33.3 REN PHOX2B NPPB LEP HCRT CRP
2 obesity-hypoventilation syndrome 32.6 LEP IL6 ADIPOQ
3 apnea, obstructive sleep 32.5 TNF REN NPPB LEP INS IL6
4 postpoliomyelitis syndrome 32.2 TNF IGF1 HCRT
5 acromegaly 32.2 LEP INS IGF1 GHRL ADIPOQ
6 polycystic ovary syndrome 32.0 LEP INS IGF1 GHRL CRP ADIPOQ
7 atrial fibrillation 32.0 NPPB IL6 CRP ACE
8 abdominal obesity-metabolic syndrome 1 32.0 LEP INS GHRL ADIPOQ
9 pulmonary disease, chronic obstructive 31.7 TNF NPPB IL6 IL1B CXCL8 CRP
10 adenoid hypertrophy 31.7 IL6 IGF1 CXCL8
11 rhinitis 31.7 TNF IL6 IL1B CXCL8
12 coronary heart disease 1 31.6 INS CRP APOE ADIPOQ ACE
13 liver disease 31.6 TNF LEP INS IL6 ADIPOQ
14 gastroesophageal reflux 31.6 TNF IL6 IL1B HTR2A GHRL CXCL8
15 headache 31.6 TNF HTR2A CXCL8
16 pulmonary hypertension 31.5 TNF REN NPPB IL6 HTR2A HIF1A
17 congestive heart failure 31.5 TNF REN NPPB INS IL6 IL1B
18 non-alcoholic fatty liver disease 31.5 TNF LEP INS IL6 IL1B CRP
19 sleep disorder 31.5 TNF REN LEP INS IL6 IL1B
20 hypercholesterolemia, familial, 1 31.5 INS CRP APOE ACE
21 atrioventricular block 31.5 NPPB CRP ACE
22 post-traumatic stress disorder 31.5 IL6 IL1B HTR2A HCRT CRP
23 cerebrovascular disease 31.5 TNF REN INS IL6 IL1B CRP
24 sickle cell anemia 31.4 TNF IL6 EDN1 CRP
25 tonsillitis 31.4 TNF IL6 IL1B CXCL8
26 mild cognitive impairment 31.4 INS IL6 IL1B APOE
27 stroke, ischemic 31.4 TNF REN NPPB INS IL6 IL1B
28 leptin deficiency or dysfunction 31.4 TNF LEP INS IL6 IL1B IGF1
29 ankylosis 31.4 TNF EDN1 CRP
30 transient cerebral ischemia 31.4 REN NPPB INS IL6 CRP APOE
31 narcolepsy 31.4 TNF LEP IL6 IL1B HTR2A HCRT
32 papilledema 31.4 IL6 CRP ACE
33 angina pectoris 31.4 TNF NPPB INS IL6 EDN1 CRP
34 aortic dissection 31.3 TNF IL6 HIF1A CRP ACE
35 respiratory failure 31.3 TNF REN NPPB INS IL6 IL1B
36 spinal cord injury 31.3 TNF LEP IL6
37 vascular disease 31.3 TNF LEP INS IL6 IGF1 EDN1
38 microvascular complications of diabetes 5 31.3 INS IGF1 HIF1A ACE
39 optic nerve disease 31.3 TNF INS IL6 IL1B EDN1 CRP
40 conjunctivitis 31.3 TNF IL6 CXCL8
41 prediabetes syndrome 31.3 LEP INS IGF1 GHRL CRP ADIPOQ
42 sudden infant death syndrome 31.2 TNF PHOX2B IL6 IL1B HTR2A HIF1A
43 lung disease 31.2 TNF NPPB IL6 IL1B IGF1 EDN1
44 common cold 31.2 TNF IL6 IL1B CXCL8 CRP
45 polycythemia 31.2 REN HIF1A EDN1 CRP ACE
46 periodontitis 31.2 TNF IL6 IL1B CXCL8 CRP
47 acute myocardial infarction 31.2 TNF REN NPPB INS IL6 EDN1
48 dementia 31.2 TNF IL6 IL1B HTR2A APOE ACE
49 atherosclerosis susceptibility 31.2 TNF LEP INS IL6 IL1B EDN1
50 non-alcoholic steatohepatitis 31.2 TNF LEP INS IL6 IL1B ADIPOQ

Comorbidity relations with Sleep Apnea via Phenotypic Disease Network (PDN):

Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Pulmonary Hypertension, Primary, 1 Respiratory Failure

Graphical network of the top 20 diseases related to Sleep Apnea:

Diseases related to Sleep Apnea

Symptoms & Phenotypes for Sleep Apnea

UMLS symptoms related to Sleep Apnea:

tremor; back pain; dyspnea; apnea; headache; syncope; excessive daytime somnolence; pain; wheezing; chronic pain; sciatica; snoring; sleep disturbances; seizures; cheyne-stokes respiration; coughing; vertigo/dizziness; sleeplessness; labored breathing; insomnia with sleep apnea, unspecified; hypersomnia with sleep apnea, unspecified; disruption of 24 hour sleep wake cycle, unspecified

MGI Mouse Phenotypes related to Sleep Apnea:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 ACE ADIPOQ APOE CRP EDN1 GHRL
2 nervous system MP:0003631 10.35 ADIPOQ APOE EDN1 HCRT HIF1A IGF1
3 muscle MP:0005369 10.32 ADIPOQ APOE EDN1 HCRT HIF1A HTR2A
4 growth/size/body region MP:0005378 10.28 ACE ADIPOQ APOE EDN1 HCRT HIF1A
5 renal/urinary system MP:0005367 10.22 ACE ADIPOQ APOE EDN1 HIF1A IGF1
6 cardiovascular system MP:0005385 10.22 ACE ADIPOQ APOE CRP EDN1 HCRT
7 adipose tissue MP:0005375 10.18 ACE ADIPOQ APOE GHRL HIF1A IGF1
8 endocrine/exocrine gland MP:0005379 10.18 ACE ADIPOQ APOE EDN1 GHRL HIF1A
9 neoplasm MP:0002006 10.15 ACE ADIPOQ HIF1A IGF1 IL1B IL6
10 liver/biliary system MP:0005370 10.1 ACE ADIPOQ APOE HIF1A IL6 INS
11 behavior/neurological MP:0005386 10.07 ACE ADIPOQ APOE GHRL HCRT HIF1A
12 digestive/alimentary MP:0005381 10.02 APOE EDN1 GHRL HIF1A HTR2A IL6
13 immune system MP:0005387 9.93 ACE ADIPOQ APOE CRP HIF1A IGF1
14 respiratory system MP:0005388 9.61 ADIPOQ APOE HCRT HIF1A IGF1 IL6
15 skeleton MP:0005390 9.36 ADIPOQ APOE EDN1 HIF1A HTR2A IGF1

Drugs & Therapeutics for Sleep Apnea

PubMed Health treatment related to Sleep Apnea: 63

Sleep apnea is treated with lifestyle changes, mouthpieces, breathing devices, and surgery . Medicines typically aren't used to treat the condition. The goals of treating sleep apnea are to: Restore regular breathing during sleep Relieve symptoms such as loud snoring and daytime sleepiness Treatment may improve other medical problems linked to sleep apnea, such as high blood pressure . Treatment also can reduce your risk for heart disease , stroke , and diabetes . If you have sleep apnea, talk with your doctor or sleep specialist about the treatment options that will work best for you. Lifestyle changes and/or mouthpieces may relieve mild sleep apnea. People who have moderate or severe sleep apnea may need breathing devices or surgery . If you continue to have daytime sleepiness despite treatment , your doctor may ask whether you're getting enough sleep . (Adults should get at least 7 to 8 hours of sleep; children and teens need more. For more information, go to the Health Topics Sleep Deprivation and Deficiency article.) If treatment and enough sleep don't relieve your daytime sleepiness, your doctor will consider other treatment options.

Drugs for Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 408)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Montelukast Approved Phase 4 158966-92-8 5281040
Opium Approved, Illicit Phase 4 8008-60-4
Hydroxychloroquine Approved Phase 4 118-42-3 3652
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Norepinephrine Approved Phase 4 51-41-2 439260
Remifentanil Approved Phase 4 132875-61-7 60815
Desflurane Approved Phase 4 57041-67-5 42113
Acetazolamide Approved, Vet_approved Phase 4 59-66-5, 1424-27-7 1986
Donepezil Approved Phase 4 120014-06-4 3152
Venlafaxine Approved Phase 4 99300-78-4, 93413-69-5 5656
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
Glycopyrronium Approved, Investigational, Vet_approved Phase 4 596-51-0, 740028-90-4 3494
Sibutramine Approved, Illicit, Investigational, Withdrawn Phase 4 106650-56-0 5210
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
Sodium oxybate Approved Phase 4 502-85-2 23663870
Budesonide Approved Phase 4 51333-22-3 5281004 40000 63006
Sorbitol Approved, Investigational Phase 4 69-65-8, 50-70-4 453 6251 5780
Eplerenone Approved Phase 4 107724-20-9 443872
Pantoprazole Approved Phase 4 102625-70-7, 138786-67-1 4679
Losartan Approved Phase 4 114798-26-4 3961
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
Atropine Approved, Vet_approved Phase 4 101-31-5, 5908-99-6, 51-55-8 3661 154417 174174
Adalimumab Approved, Experimental Phase 4 331731-18-1
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
Tramadol Approved, Investigational Phase 4 27203-92-5 33741 5523
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Ethanol Approved Phase 4 64-17-5 702
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
Promethazine Approved, Investigational Phase 4 60-87-7 4927
Ondansetron Approved, Withdrawn Phase 4 99614-02-5 4595
Zolpidem Approved Phase 4 82626-48-0 5732
Racephedrine Approved, Experimental Phase 4 299-42-3, 90-82-4, 90-81-3 5032 9294 7028
Phenylephrine Approved Phase 4 59-42-7 6041
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456 5824
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
Carbidopa Approved Phase 4 28860-95-9 34359 38101
Levodopa Approved Phase 4 59-92-7, 63-84-3 6047
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
Finasteride Approved Phase 4 98319-26-7 57363
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290

Interventional clinical trials:

(show top 50) (show all 2333)
# Name Status NCT ID Phase Drugs
1 Acetazolamide as add-on Therapy to Obstructive Sleep Apnea Surgery (ACTOS): a Parallel-group, Double-blind, Placebo-controlled, Randomized Trial Unknown status NCT04227093 Phase 4 Acetazolamide;Placebo
2 Cost-utility Study of CPAP Treatment in Obstructive Sleep Apnea Patients Unknown status NCT01590420 Phase 4
3 Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption Unknown status NCT02371473 Phase 4 Acetazolamide-placebo;Placebo-acetazolamide
4 Effect of Treating Sleep Apnea With Oral Appliances in the Elderly: ORACLE Study Unknown status NCT02325089 Phase 4
5 Donepezil Treatment for Sleep Apnea Patients: A Double Blind Placebo-Controlled Study Unknown status NCT00912457 Phase 4 donepezil;placebo
6 Open, Prospective Study for the Validation of the Predictive Value of Upper Airway Segmentation and CFD Analysis on Outcome Parameters of the Mandibular Replacement Appliance (MRA) Therapy in Obstructive Sleep Apnea Hypopnea Syndrome OSAHS) Patients Unknown status NCT01524510 Phase 4
7 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
8 Comparison of the Pentax AWS® With the Macintosh Laryngoscope for Tracheal Intubation in Patients With Obstructive Sleep Apnea Syndrome: a Randomized Comparative Study Unknown status NCT01428570 Phase 4
9 Effects of Continuous Positive Airway Pressure (CPAP) and Nebivolol Treatment on Arterial Blood Pressure and Endothelial Function in Hypertensive OSA Patients. Unknown status NCT01771406 Phase 4 Nebivolol
10 Effects of the Continuous Positive Airway Pressure Ventilation on the Prevalence of the Metabolic Syndrome and Cardiac Morpho-Functional Characteristics in Sleep Apnea Syndrome Unknown status NCT00517777 Phase 4
11 Blood Pressure Reduction Induced by Continuous Positive Airway Pressure (CPAP) in Sleep Apnea Patients at High Cardiovascular Risk : A Randomized Controlled Trial Comparing Usual CPAP Care Versus a Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform Unknown status NCT01505959 Phase 4
12 Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving Continuous Positive Airway Pressure (CPAP) Compliance in Low Cardiovascular Risk Sleep Apnea Patients Unknown status NCT01796769 Phase 4
13 Randomised Monocentric -Controlled Study to Evaluate the Efficacy and Stability of Dexmedetomidine Sedation Compared to Propofol Sedation in the Routinely Diagnostic Examination: Drug Induced Sleep Endoscopy Unknown status NCT03892122 Phase 4 Propofol Fresenius;Dexmedetomidine
14 Effect of Servo-Ventilation on CO2 Regulation and Heart Rate Variability Unknown status NCT03890939 Phase 4
15 A Comparison Between Two Different Oral Appliance Therapies: Somnodent vs Herbst Appliance in Patients With Mild and Moderate OSA Unknown status NCT02724865 Phase 4
16 Effect of Hydroxychloroquine on Endothelial Function: a Clinical Trial Unknown status NCT04161339 Phase 4 Hydroxychloroquine;Placebo oral tablet
17 Inflammatory Response to Anti Inflammatory Therapy in Children With Sleep Disordered Breathing Unknown status NCT00299910 Phase 4 Montelukast
18 Sleep Disordered Breathing in TIA/Ischemic Stroke: Effects on Short- and Long-term Outcome and CPAP Treatment Efficacy: an Open, Observational, Clinical, Multicentre Trial With a Randomized Arm Unknown status NCT01097967 Phase 4
19 The Effect of Nasal CPAP in Patients With Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
20 Respiratory Impact of Short Life Agents Used in Balanced Anesthesia on Patients Suffering or Suspected of Obstructive Sleep Apnea (OSA) Syndrome Completed NCT02717780 Phase 4 Fentanyl and sevoflurane;Remifentanil and desflurane
21 The Impact of Arousal Threshold in Obstructive Sleep Apnea: Donepezil's Effects on the Arousal Threshold and on the Apnea Hypopnea Index Completed NCT02264353 Phase 4 Donepezil;placebo
22 Phase 4 Study of the Relationship Between the Oxidative Stress and the Development of Cardiovascular Complications in the Sleep Apnea-hypopnea Syndrome (SAHS). Effect of the Treatment With CPAP Completed NCT00487929 Phase 4
23 Effects of Continuous Positive Airway Pressure (CPAP) on Early Signs of Atherosclerosis in Patients With Obstructive Sleep Apnea: a Randomized Study Completed NCT00400543 Phase 4
24 Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study (SHARP): a 5-Week Double-blind, Placebo-controlled, Randomized, Crossover, Multicenter Study of Solriamfetol in Improving Cognitive Function in Participants With Excessive Daytime Sleepiness Associated With Obstructive Sleep Apnea Plus Impaired Cognitive Function Completed NCT04789174 Phase 4 Solriamfetol;Placebo
25 Prospective, Randomized, Placebo Controlled Trial Assessing the Effects of Ezopiclone on the Quality of Overnight Polysomnography and CPAP Titration Completed NCT00507117 Phase 4 Lunesta;Placebo control
26 The Effect of Anticholinesterase Drugs on Sleep in Alzheimer's Disease Patients Completed NCT00480870 Phase 4 donepezil;Placebo
27 The Effect of Trazodone on the Severity of Obstructive Sleep Apnea in Insomnic Stroke Patients With Depression Completed NCT04162743 Phase 4 Trazodone;Placebo oral tablet
28 Impact of Obstructive Sleep Apnea Treatment in Patients With Metabolic Syndrome: A Randomized Study Completed NCT02295202 Phase 4
29 The Endothelium Dysfunction in Patients of Obstructive Sleep Apnea Syndrome Completed NCT01699126 Phase 4 Statin
30 Dexmedetomidine Added to Propofol for Drug Induced Sleep Endoscopy in Adult Patients With Obstructive Sleep Apnea: A Prospective Randomized Controlled Trial Completed NCT03091894 Phase 4 Propofol;Dexmedetomidine
31 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF Completed NCT00551499 Phase 4
32 Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome With Major Depressive Disorder or Dysthymic Disorder Completed NCT00518986 Phase 4 armodafinil;placebo
33 Renal Hemodynamics and Tubular Function in Patients With Obstructive Sleep Apnea and Healthy Controls Completed NCT00410085 Phase 4 L-NMMA (N-mono.methyl-L-arginine)
34 Comparative Study of Effect of Valsartan 160mg Treatment Versus Continuous Positive Airway Pressure on Arterial Blood Pressure in Patients Who Have an Obstructive Sleep Apnea Syndrome and a Weak or Moderate Hypertension. Completed NCT00409487 Phase 4 Valsartant treatment
35 The Effect of Sodium-Restricted Diet and Diuretic in the Severe Sleep Apnea: a Randomized Controlled Trial - DESALT Study Completed NCT01945801 Phase 4 Lasilactone;Placebo
36 Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery And Postoperative Complications In Patients With Obstructive Sleep Apnea Undergoing Bariatric Surgery: A Double-Blind, Randomized Controlled Trial Completed NCT03679611 Phase 4 Sugammadex Sodium;Neostigmine
37 The Impact of Venlafaxine on Apnea Hypopnea Index in Patients With Obstructive Sleep Apnea Completed NCT02714400 Phase 4 Venlafaxine;Placebo
38 Randomized, Double-blind Study to Compare Safety and Effectiveness of the ProventTM Professional Sleep Apnea Therapy Device to Sham for the Non-invasive Treatment of OSAH Completed NCT00772044 Phase 4
39 Efficacy of Sibutramine-induced Weight Loss vs. Continuous Positive Airway Pressure (CPAP) in the Treatment of Obese Patients With Obstructive Sleep Apnea Completed NCT00729963 Phase 4 Sibutramine
40 Differential Effects of Chronic Treatment of OSAS by CPAP and SOMNOsmart2 on Norepinephrine and Blood Pressure Completed NCT00633711 Phase 4
41 Does Nasal Decongestion Improve Obstructive Sleep Apnea ? Completed NCT00630474 Phase 4 xylometazoline
42 Inspire® Upper Airway Stimulation (UAS) System German Post-Market Study: CE Certificate Number 562872 Completed NCT02293746 Phase 4
43 SASQT: SensAwake™ Sleep Quality Trial A Study to Test the Efficacy of the SensAwake™ Modification to Automatically Titrating Continuous Positive Airway Pressure to Reduce Wake After Sleep Onset in Patients With Moderate to Severe Obstructive Sleep Apnea. Completed NCT00811213 Phase 4
44 Cardiovascular Impact of Obstructive Sleep Apnea in Normotensive Patients and the Effects of Continuous Positive Airway Pressure Completed NCT00741520 Phase 4
45 A Placebo Controlled Double Blinded Crossover Study of the Antihypertensive Efficacy of Guanfacine vs Hydrochlorothiazide in Obstructive Sleep Apnea (OSA) Associated Hypertension Completed NCT02699125 Phase 4 Guanfacine;Hydrochlorothiazide
46 Sleep Apnea-hypopnea Syndrome and Ventricular Arrhythmias in Patients With Systolic Ventricular Dysfunction and Implantable Cardioverter-defibrillator. Incidence and Effect of CPAP Treatment Completed NCT00765713 Phase 4
47 Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude Completed NCT00714740 Phase 4 acetazolamide
48 Randomized Intervention With CPAP in Coronary Artery Disease and Sleep Apnea - RICCADSA Trial Completed NCT00519597 Phase 4
49 Ketamine Infusion for Pediatric Patients With Obstructive Sleep Apnea Syndrome After Tonsillectomy: A Randomized Controlled Trial Completed NCT02425202 Phase 4 Ketamine
50 Effect of Combined Use of Tolterodine and Continuous Positive Airway Pressure vs Continuous Positive Airway Pressure Only Treatment on Overactive Bladder Symptoms in Women With Moderate-to-severe Obstructive Sleep Apnea Syndrome: A Randomized Clinical Trial Completed NCT05250245 Phase 4 Tolterodine Tartrate 4 MG

Search NIH Clinical Center for Sleep Apnea

Cochrane evidence based reviews: sleep apnea syndromes

Genetic Tests for Sleep Apnea

Genetic tests related to Sleep Apnea:

# Genetic test Affiliating Genes
1 Sleep Apnea 28

Anatomical Context for Sleep Apnea

Organs/tissues related to Sleep Apnea:

MalaCards : Heart, Lung, Tongue, Endothelial, Spinal Cord, Brain, Liver

Publications for Sleep Apnea

Articles related to Sleep Apnea:

(show top 50) (show all 30001)
# Title Authors PMID Year
De novo truncating mutations in AHDC1 in individuals with syndromic expressive language delay, hypotonia, and sleep apnea. 62 5
24791903 2014
Review of Application of Machine Learning as a Screening Tool for Diagnosis of Obstructive Sleep Apnea. 62 41
36363530 2022
Experimental Models to Study End-Organ Morbidity in Sleep Apnea: Lessons Learned and Future Directions. 62 41
36430904 2022
Impact of sleep disordered breathing on postoperative atrial fibrillation in patients who underwent cardiac surgery: a meta-analysis. 41
36351877 2022
The effectiveness of positive airway pressure therapy in reducing postoperative adverse outcomes in surgical patients with obstructive sleep apnea: A systematic review and meta-analysis. 62
36347195 2023
Orthognathic Surgery for Obstructive Sleep Apnea. 62
36336592 2023
The Use of Continuous Positive Airway Ventilation for Patients With Obstructive Sleep Apnea is Associated With Early Medical and Surgery-related Complications Following Total Hip Arthroplasty: A National Database Study. 62
36471772 2023
Children Undergoing Laryngeal Surgery for Obstructive Sleep Apnea: NSQIP Analysis of Length of Stay, Readmissions, and Reoperations. 62
35172622 2023
Epidemiological Study of Parental Obstructive Sleep Apnea and Subsequent Risk of ADHD in Their Children: A Nationwide Population-Based Study. 62
36113004 2023
Parameters affecting improvement of excessive daytime sleepiness in obstructive sleep apnea patients. 62
36323161 2023
Obstructive sleep apnea reduces functional capacity and impairs cardiac autonomic modulation during submaximal exercise in patients with chronic obstructive pulmonary disease: A follow-up study. 62
36332349 2023
Validity of a New Prediction Model to Identify Patients at Risk for Obstructive Sleep Apnea Hypopnea Syndrome. 62
33393817 2023
Socioeconomic Correlates of Keratoconus Severity and Progression. 62
35184126 2023
The Role of Sleep in Cognitive Function: The Value of a Good Night's Rest. 62
35369784 2023
Sleep and risk of hypertension in general American adults: the National Health and Nutrition Examination Surveys (2015-2018). 62
36129105 2023
Chronic intermittent hypoxia enhances glycinergic inhibition in nucleus tractus solitarius. 62
36321700 2022
Intermittent Hypoxia Differentially Regulates Adenosine Receptors in Phrenic Motor Neurons with Spinal Cord Injury. 62
36273657 2022
Within- and cross-mental health disorder correlations in husband-and-wife pairs. 62
36471289 2022
Sleep disorders are associated with testosterone deficiency and erectile dysfunction-a U.S. claims database analysis. 62
36473958 2022
Exosomes, sleep apnea, and cardiovascular disease: Implications for pathogenesis and promises for prevention. 62
36410077 2022
Racial Differences in Positive Airway Pressure Adherence in the Treatment of Sleep Apnea. 62
36333073 2022
[State of knowledge on sleep apnea syndrome, attitudes and practices of doctors in Niamey, Niger]. 62
36471524 2022
Alternative Sleep Apnea Treatment: Reply. 62
36473090 2022
Design of the remedē System Therapy (rēST) study: A prospective non-randomized post-market study collecting clinical data on safety and effectiveness of the remedē system for the treatment of central sleep apnea. 62
36116293 2022
Continuous Positive Airway Pressure Therapy for Sleep Apnea: A Newly Controversial Topic. 62
36333084 2022
Alternative Sleep Apnea Treatment: Comment. 62
36473092 2022
Addressing rural health disparity with a novel hospital sleep apnea screening: Precision of a high-resolution pulse oximeter in screening for sleep-disordered breathing. 62
35050464 2022
Effect of adaptive servo ventilation on central sleep apnea and sleep structure in systolic heart failure patients: polysomnography data from the SERVE-HF major sub study. 62
35840352 2022
The association between sleep deprivation and arterial pressure variations: a systematic literature review. 62
35169694 2022
Continuous positive airway pressure adherence in people with obstructive sleep apnoea. 62
34962327 2022
A pilot study on comparison of subjective titration versus remotely controlled mandibular positioning during polysomnography and drug-induced sleep endoscopy, to determine the effective protrusive position for mandibular advancement device therapy. 62
35064876 2022
Spinal cord injury-induced cognitive impairment: a narrative review. 62
35662196 2022
Ambulatory Blood Pressure Variability after Adenotonsillectomy in Childhood Sleep Apnea. 62
35156724 2022
Multimodal phenotypic labelling using drug-induced sleep endoscopy, awake nasendoscopy and computational fluid dynamics for the prediction of mandibular advancement device treatment outcome: a prospective study. 62
35734809 2022
Sleep position, patient comfort, and technical performance with two established procedures for home sleep testing. 62
34970703 2022
Solriamfetol for the Management of Excessive Daytime Sleepiness. 62
33882756 2022
Phenotyping OSAH patients during wakefulness. 62
35023036 2022
Lateral pharyngoplasty vs. traditional uvulopalatopharyngoplasty for patients with OSA: systematic review and meta-analysis. 62
34978022 2022
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Comorbid Insomnia and Sleep Apnea: Assessment and Management Approaches. 62
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End-tidal and transcutaneous CO2 monitoring during sleep in children aged under three with suspected Sleep Apnea. 62
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Variations for Sleep Apnea

ClinVar genetic disease variations for Sleep Apnea:

# Gene Name Type Significance ClinVarId dbSNP ID Position
1 AHDC1 NM_001371928.1(AHDC1):c.2373_2374del (p.Cys791fs) MICROSAT Pathogenic
133326 rs587779766 GRCh37: 1:27876253-27876254
GRCh38: 1:27549742-27549743
2 AHDC1 NM_001371928.1(AHDC1):c.2898del (p.Tyr967fs) DEL Pathogenic
133327 rs587779767 GRCh37: 1:27875729-27875729
GRCh38: 1:27549218-27549218
3 AHDC1 NM_001371928.1(AHDC1):c.2547del (p.Ser850fs) DEL Pathogenic
133328 rs587779768 GRCh37: 1:27876080-27876080
GRCh38: 1:27549569-27549569
4 MT-CO3 NC_012920.1:m.9355A>T SNV Uncertain Significance
523307 rs1556423663 GRCh37: MT:9355-9355
GRCh38: MT:9355-9355

Expression for Sleep Apnea

Search GEO for disease gene expression data for Sleep Apnea.

Pathways for Sleep Apnea

Pathways related to Sleep Apnea according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
5 12.67 INS IL6 IL1B IGF1 HIF1A
Show member pathways
Show member pathways
12.49 CXCL8 IL1B IL6 TNF
Show member pathways
Show member pathways
Show member pathways
Show member pathways
12 12.09 IGF1 IL1B IL6 TNF
13 12.02 CXCL8 IL1B IL6 LEP TNF
14 11.98 TNF IL6 IL1B HIF1A CXCL8
15 11.96 INS IL6 IL1B IGF1 CXCL8
Show member pathways
19 11.78 LEP IL6 IGF1
20 11.77 CXCL8 IL1B IL6 TNF
21 11.74 TNF IL6 IL1B
22 11.73 IL6 HIF1A EDN1 CXCL8
23 11.71 TNF IL6 CRP
24 11.7 IL6 IL1B HIF1A
Show member pathways
11.68 TNF IL6 IL1B CXCL8
26 11.67 LEP HIF1A EDN1
27 11.65 TNF IL6 CXCL8
28 11.64 TNF IL6 IL1B
29 11.6 CXCL8 IL6 INS
30 11.58 IL6 HIF1A CXCL8
31 11.55 TNF IL6 IL1B CXCL8
32 11.54 TNF IL6 CXCL8
33 11.51 INS IL6 IGF1
35 11.36 TNF IL6 IL1B
36 11.31 TNF IL6 IL1B
37 11.31 TNF IL6 IL1B IGF1 APOE
39 11.27 TNF IL6 IL1B
40 11.27 CXCL8 IL1B IL6 TNF
Show member pathways
42 11.25 TNF IL1B IGF1
43 11.23 TNF IL6 IL1B IGF1 EDN1 CXCL8
44 11.22 TNF IL6 CXCL8
45 11.2 TNF IL6 IL1B CXCL8
46 11.09 LEP INS GHRL
48 10.95 TNF IL6 CXCL8 CRP
49 10.7 IL6 CXCL8
Show member pathways
10.4 TNF IL6 CXCL8

GO Terms for Sleep Apnea

Cellular components related to Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.16 ACE ADIPOQ APOE CRP CXCL8 EDN1
2 extracellular space GO:0005615 9.8 ACE ADIPOQ APOE CRP CXCL8 EDN1

Biological processes related to Sleep Apnea according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.59 TNF LEP INS IL6 IL1B IGF1
2 positive regulation of cell population proliferation GO:0008284 10.47 EDN1 HTR2A IGF1 IL1B IL6 INS
3 positive regulation of gene expression GO:0010628 10.44 CRP CXCL8 HIF1A IGF1 IL1B IL6
4 defense response to Gram-positive bacterium GO:0050830 10.32 CRP IL1B IL6 TNF
5 positive regulation of DNA-binding transcription factor activity GO:0051091 10.31 TNF IL6 IL1B EDN1
6 positive regulation of protein kinase B signaling GO:0051897 10.31 TNF LEP INS IGF1
7 positive regulation of interleukin-6 production GO:0032755 10.29 IL1B IL6 LEP TNF
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 10.28 ADIPOQ HTR2A IGF1 IL6
9 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 10.27 TNF LEP INS IGF1
10 response to lipopolysaccharide GO:0032496 10.27 ACE EDN1 IL1B REN TNF
11 positive regulation of MAPK cascade GO:0043410 10.27 GHRL IGF1 IL6 INS LEP TNF
12 positive regulation of MAP kinase activity GO:0043406 10.26 TNF IL1B HTR2A EDN1
13 response to xenobiotic stimulus GO:0009410 10.25 ACE ADIPOQ EDN1 HTR2A REN TNF
14 positive regulation of cold-induced thermogenesis GO:0120162 10.25 PHOX2B LEP HCRT GHRL ADIPOQ
15 response to hypoxia GO:0001666 10.25 ACE ADIPOQ EDN1 HIF1A LEP TNF
16 cellular response to xenobiotic stimulus GO:0071466 10.23 REN IL1B EDN1 ADIPOQ
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.23 TNF LEP IL6 IGF1
18 glucose homeostasis GO:0042593 10.23 LEP INS IL6 HIF1A ADIPOQ
19 negative regulation of gene expression GO:0010629 10.22 TNF INS IGF1 HIF1A EDN1 CXCL8
20 positive regulation of smooth muscle cell proliferation GO:0048661 10.21 TNF IL6 IGF1 EDN1
21 positive regulation of nitric oxide biosynthetic process GO:0045429 10.2 TNF IL1B EDN1
22 acute-phase response GO:0006953 10.19 INS IL6 CRP
23 regulation of insulin secretion GO:0050796 10.19 TNF LEP IL6 IL1B
24 positive regulation of glucose import GO:0046326 10.18 ADIPOQ IGF1 INS
25 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.18 TNF LEP IL6
26 negative regulation of endothelial cell proliferation GO:0001937 10.18 TNF GHRL APOE
27 regulation of blood pressure GO:0008217 10.18 REN NPPB LEP EDN1 ACE
28 positive regulation of interleukin-8 production GO:0032757 10.18 TNF LEP IL6 IL1B ADIPOQ
29 positive regulation of vascular endothelial growth factor production GO:0010575 10.17 IL6 IL1B HIF1A
30 eating behavior GO:0042755 10.16 LEP HCRT ACE
31 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.16 TNF IL6 HIF1A
32 vasodilation GO:0042311 10.16 TNF NPPB INS APOE
33 negative regulation of neurogenesis GO:0050768 10.15 TNF IL6 IL1B
34 vasoconstriction GO:0042310 10.13 EDN1 CRP ACE
35 positive regulation of chemokine production GO:0032722 10.13 TNF IL6 IL1B HIF1A
36 positive regulation of cytokine production GO:0001819 10.12 TNF LEP INS IL1B
37 negative regulation of lipid catabolic process GO:0050995 10.12 IL1B INS TNF
38 positive regulation of glial cell proliferation GO:0060252 10.11 IL1B IL6 TNF
39 positive regulation of membrane protein ectodomain proteolysis GO:0051044 10.1 TNF IL1B APOE
40 glucose metabolic process GO:0006006 10.1 ADIPOQ GHRL INS LEP TNF
41 blood vessel diameter maintenance GO:0097746 10.09 NPPB EDN1 ACE
42 negative regulation of glucose import GO:0046325 10.09 TNF LEP ACE
43 positive regulation of nitric-oxide synthase activity GO:0051000 10.06 APOE HIF1A INS TNF
44 positive regulation of neuroinflammatory response GO:0150078 10.04 IL1B IL6 TNF
45 positive regulation of glycolytic process GO:0045821 10.03 INS IGF1 HTR2A HIF1A
46 positive regulation of fever generation GO:0031622 10.02 TNF IL1B
47 positive regulation of dendritic spine maintenance GO:1902952 10 INS APOE
48 sequestering of triglyceride GO:0030730 10 TNF IL1B
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.99 TNF IL1B
50 elastin metabolic process GO:0051541 9.97 HIF1A LEP

Molecular functions related to Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.9 TNF IL6 IL1B EDN1 CXCL8 ADIPOQ
2 insulin-like growth factor receptor binding GO:0005159 9.73 REN INS IGF1
3 signaling receptor binding GO:0005102 9.73 ADIPOQ APOE EDN1 IL6 LEP NPPB
4 hormone activity GO:0005179 9.44 NPPB LEP INS IGF1 GHRL EDN1

Sources for Sleep Apnea

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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