Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: SLP006
MIFTS: 69

Sleep Apnea

Categories: Mental diseases, Neuronal diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Sleep Apnea

About this section

MalaCards integrated aliases for Sleep Apnea:

Name: Sleep Apnea 12 53 29 6 42 15 62 17
Sleep Apnea Syndromes 44 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Mental diseases Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0050847
ICD9CM 34 780.57
MeSH 44 D012891
NCIt 50 C26884
SNOMED-CT 67 206750008
ICD10 32 G47.3
UMLS 71 C0037315
Sources

Summaries for Sleep Apnea

About this section
NINDS : 53 Sleep apnea is a common sleep disorder characterized by brief interruptions of breathing during sleep.  These episodes usually last 10 seconds or more and occur repeatedly throughout the night.  People with sleep apnea will partially awaken as they struggle to breathe, but in the morning they will not be aware of the disturbances in their sleep.  The most common type of sleep apnea is obstructive sleep apnea (OSA), caused by relaxation of soft tissue in the back of the throat that blocks the passage of air.  Central sleep apnea (CSA) is caused by irregularities in the brain’s normal signals to breathe.  Most people with sleep apnea will have a combination of both types.  The hallmark symptom of the disorder is excessive daytime sleepiness. Additional symptoms of sleep apnea include restless sleep, loud snoring (with periods of silence followed by gasps), falling asleep during the day, morning headaches, trouble concentrating, irritability, forgetfulness, mood or behavior changes, anxiety, and depression.  Not everyone who has these symptoms will have sleep apnea, but it is recommended that people who are experiencing even a few of these symptoms visit their doctor for evaluation.  Sleep apnea is more likely to occur in men than women, and in people who are overweight or obese.

MalaCards based summary : Sleep Apnea, also known as sleep apnea syndromes, is related to central sleep apnea and obesity-hypoventilation syndrome, and has symptoms including seizures, tremor and back pain. An important gene associated with Sleep Apnea is AHDC1 (AT-Hook DNA Binding Motif Containing 1), and among its related pathways/superpathways are Signaling by GPCR and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Phenylephrine and Zopiclone have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and tongue, and related phenotypes are cardiovascular system and behavior/neurological

Disease Ontology : 12 A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep.

MedlinePlus : 42 Sleep apnea is a common disorder that causes your breathing to stop or get very shallow. Breathing pauses can last from a few seconds to minutes. They may occur 30 times or more an hour. The most common type is obstructive sleep apnea. It causes your airway to collapse or become blocked during sleep. Normal breathing starts again with a snort or choking sound. People with sleep apnea often snore loudly. However, not everyone who snores has sleep apnea. You are more at risk for sleep apnea if you are overweight, male, or have a family history or small airways. Children with enlarged tonsils or adenoids may also get it. Doctors diagnose sleep apnea based on medical and family histories, a physical exam, and sleep study results. When your sleep is interrupted throughout the night, you can be drowsy during the day. People with sleep apnea are at higher risk for car crashes, work-related accidents, and other medical problems. If you have it, it is important to get treatment. Lifestyle changes, mouthpieces, surgery, and breathing devices can treat sleep apnea in many people. NIH: National Heart, Lung, and Blood Institute

PubMed Health : 62 About sleep apnea: Sleep apnea (AP-ne-ah) is a common disorder in which you have one or more pauses in breathing or shallow breaths while you sleep. Breathing pauses can last from a few seconds to minutes. They may occur 30 times or more an hour. Typically, normal breathing then starts again, sometimes with a loud snort or choking sound. Sleep apnea usually is a chronic (ongoing) condition that disrupts your sleep. When your breathing pauses or becomes shallow, you’ll often move out of deep sleep and into light sleep. As a result, the quality of your sleep is poor, which makes you tired during the day. Sleep apnea is a leading cause of excessive daytime sleepiness.

Wikipedia : 74 Sleep apnea, also spelled sleep apnoea, is a sleep disorder in which pauses in breathing or periods of... more...

Sources

Related Diseases for Sleep Apnea

About this section

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1355)
# Related Disease Score Top Affiliating Genes
1 central sleep apnea 32.9 REN PHOX2B NPPB LEP HCRT CRP
2 obesity-hypoventilation syndrome 32.6 LEP IL6 ADIPOQ
3 postpoliomyelitis syndrome 32.1 TNF IGF1 HCRT
4 acromegaly 32.0 LEPR LEP INS IGF1 GHRL ADIPOQ
5 polycystic ovary syndrome 31.9 LEP INS IGF1 GHRL ADIPOQ
6 congestive heart failure 31.8 TNF REN NPPB INS IL6 EDN1
7 lipid metabolism disorder 31.8 LEP INS IL6 CRP APOE ADIPOQ
8 impotence 31.8 INS EDN1 ACE
9 ischemia 31.7 NPPB HIF1A EDN1 ACE
10 apnea, obstructive sleep 31.7 TNF REN PHOX2B NPPB LEP INS
11 coronary heart disease 1 31.7 INS CRP APOE ADIPOQ ACE
12 pulmonary disease, chronic obstructive 31.6 TNF NPPB INS IL6 CXCL8 CRP
13 optic nerve disease 31.6 TNF IL6 EDN1 CRP ACE
14 gastroesophageal reflux 31.6 TNF IL6 HTR2A GHRL CXCL8 ADIPOQ
15 post-traumatic stress disorder 31.6 HTR2A CRP APOE ADIPOQ
16 tonsillitis 31.6 TNF IL6 CXCL8
17 fatty liver disease 31.5 TNF LEPR LEP INS IL6 CXCL8
18 intracranial hypertension 31.5 TNF NPPB ADIPOQ
19 mental depression 31.5 TNF INS IL6 HTR2A CRP
20 stroke, ischemic 31.4 TNF REN NPPB IL6 CRP APOE
21 hypercholesterolemia, familial, 1 31.4 INS CRP APOE ACE
22 mood disorder 31.4 IL6 HTR2A HIF1A ACE
23 ankylosis 31.4 TNF HIF1A EDN1
24 nonarteritic anterior ischemic optic neuropathy 31.4 EDN1 CRP ACE
25 pustulosis of palm and sole 31.4 TNF CXCL8 CRP
26 liver disease 31.3 TNF LEPR LEP INS IL6 CXCL8
27 lung disease 31.3 TNF NPPB INS IL6 EDN1 CXCL8
28 conjunctivitis 31.3 TNF IL6 CXCL8
29 covid-19 31.3 NPPB IL6 CXCL8 ACE
30 acute myocardial infarction 31.3 NPPB IL6 EDN1 CRP ACE
31 patent foramen ovale 31.3 REN NPPB EDN1 CRP ACE
32 atherosclerosis susceptibility 31.3 TNF LEP INS IL6 EDN1 CXCL8
33 narcolepsy 31.3 TNF LEP IL6 HTR2A HCRT GHRL
34 spinal cord injury 31.3 TNF LEP IL6 CXCL8
35 sudden infant death syndrome 31.2 TNF PHOX2B IL6 HTR2A CXCL8
36 periodontitis 31.2 TNF IL6 CXCL8 CRP
37 retinal vein occlusion 31.2 TNF IL6 EDN1 CXCL8 ACE
38 systolic heart failure 31.2 TNF NPPB IL6 EDN1 CRP ADIPOQ
39 respiratory failure 31.2 TNF REN NPPB IL6 HCRT EDN1
40 arteries, anomalies of 31.2 TNF REN LEP INS IL6 EDN1
41 open-angle glaucoma 31.2 TNF IL6 EDN1 CXCL8 APOE ACE
42 bronchitis 31.2 TNF IL6 CXCL8 CRP
43 traumatic brain injury 31.1 IL6 IGF1 APOE
44 cerebrovascular disease 31.1 TNF REN NPPB LEP INS IL6
45 hypothyroidism 31.1 TNF REN LEP INS IGF1 CRP
46 intermediate coronary syndrome 31.1 INS IL6 CRP ACE
47 gout 31.1 TNF INS IL6 CXCL8
48 aortic aneurysm 31.1 IL6 CRP APOE ACE
49 end stage renal disease 31.1 TNF REN NPPB LEP INS IL6
50 brain injury 31.1 IL6 IGF1 APOE

Comorbidity relations with Sleep Apnea via Phenotypic Disease Network (PDN):


Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Pulmonary Hypertension, Primary, 1 Respiratory Failure

Graphical network of the top 20 diseases related to Sleep Apnea:



Diseases related to Sleep Apnea
Sources

Symptoms & Phenotypes for Sleep Apnea

About this section

UMLS symptoms related to Sleep Apnea:


seizures, tremor, back pain, dyspnea, apnea, headache, syncope, excessive daytime somnolence, pain, wheezing, chronic pain, sciatica, snoring, sleep disturbances, cheyne-stokes respiration, coughing, vertigo/dizziness, sleeplessness, labored breathing, insomnia with sleep apnea, unspecified, hypersomnia with sleep apnea, unspecified, disruption of 24 hour sleep wake cycle, unspecified

MGI Mouse Phenotypes related to Sleep Apnea:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.41 ACE ADIPOQ APOE CRP EDN1 HCRT
2 behavior/neurological MP:0005386 10.39 ACE ADIPOQ APOE GHRL HCRT HIF1A
3 homeostasis/metabolism MP:0005376 10.38 ACE ADIPOQ APOE CRP EDN1 GHRL
4 growth/size/body region MP:0005378 10.34 ACE ADIPOQ APOE EDN1 HCRT HIF1A
5 endocrine/exocrine gland MP:0005379 10.32 ACE ADIPOQ APOE EDN1 GHRL HIF1A
6 adipose tissue MP:0005375 10.26 ACE ADIPOQ APOE GHRL IGF1 IL6
7 immune system MP:0005387 10.23 ACE ADIPOQ APOE CRP HIF1A IGF1
8 digestive/alimentary MP:0005381 10.22 APOE EDN1 GHRL HIF1A HTR2A IL6
9 muscle MP:0005369 10.18 ADIPOQ APOE EDN1 HCRT HIF1A HTR2A
10 nervous system MP:0003631 10.1 ACE ADIPOQ APOE EDN1 HCRT HIF1A
11 integument MP:0010771 10.09 ADIPOQ APOE HIF1A IGF1 IL6 INS
12 liver/biliary system MP:0005370 10.06 ACE ADIPOQ APOE HIF1A IL6 INS
13 neoplasm MP:0002006 9.92 ACE ADIPOQ HIF1A IGF1 IL6 LEP
14 renal/urinary system MP:0005367 9.9 ACE ADIPOQ APOE EDN1 HIF1A IGF1
15 respiratory system MP:0005388 9.65 ADIPOQ APOE HCRT HIF1A IGF1 IL6
16 skeleton MP:0005390 9.36 ADIPOQ APOE EDN1 HIF1A HTR2A IGF1
Sources

Drugs & Therapeutics for Sleep Apnea

About this section

PubMed Health treatment related to Sleep Apnea: 62

Sleep apnea is treated with lifestyle changes, mouthpieces, breathing devices, and surgery . Medicines typically aren't used to treat the condition. The goals of treating sleep apnea are to: Restore regular breathing during sleep Relieve symptoms such as loud snoring and daytime sleepiness Treatment may improve other medical problems linked to sleep apnea, such as high blood pressure . Treatment also can reduce your risk for heart disease , stroke , and diabetes . If you have sleep apnea, talk with your doctor or sleep specialist about the treatment options that will work best for you. Lifestyle changes and/or mouthpieces may relieve mild sleep apnea. People who have moderate or severe sleep apnea may need breathing devices or surgery . If you continue to have daytime sleepiness despite treatment , your doctor may ask whether you're getting enough sleep . (Adults should get at least 7 to 8 hours of sleep; children and teens need more. For more information, go to the Health Topics Sleep Deprivation and Deficiency article.) If treatment and enough sleep don't relieve your daytime sleepiness, your doctor will consider other treatment options.

Drugs for Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 393)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenylephrine Approved Phase 4 59-42-7 6041
2
Zopiclone Approved Phase 4 43200-80-2 5735
3
Opium Approved, Illicit Phase 4 8008-60-4
4
Donepezil Approved Phase 4 120014-06-4 3152
5
Ephedrine Approved Phase 4 299-42-3 9294
6
Pseudoephedrine Approved Phase 4 90-82-4 7028
7
Remifentanil Approved Phase 4 132875-61-7 60815
8
Desflurane Approved Phase 4 57041-67-5 42113
9
Sodium citrate Approved, Investigational Phase 4 68-04-2
10
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
11
Sodium oxybate Approved Phase 4 502-85-2 5360545
12
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
13
Morphine Approved, Investigational Phase 4 57-27-2 5288826
14
Budesonide Approved Phase 4 51333-22-3 63006 5281004
15
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
16
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
17
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
18
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
19
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
20
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
21
Adalimumab Approved, Experimental Phase 4 331731-18-1 16219006
22
Pantoprazole Approved Phase 4 102625-70-7 4679
23
Losartan Approved Phase 4 114798-26-4 3961
24
Eplerenone Approved Phase 4 107724-20-9 150310 443872
25
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
26
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
27
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
28
Finasteride Approved Phase 4 98319-26-7 57363
29
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
30
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
31
Ethanol Approved Phase 4 64-17-5 702
32
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
33
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
34
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
35
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
36
Zolpidem Approved Phase 4 82626-48-0 5732
37
Promethazine Approved, Investigational Phase 4 60-87-7 4927
38
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
39
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
40
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
41
Liraglutide Approved Phase 4 204656-20-2 44147092
42
Levodopa Approved Phase 4 59-92-7 6047
43
Carbidopa Approved Phase 4 28860-95-9 34359
44
Metformin Approved Phase 4 657-24-9 14219 4091
45
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
46
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
47
Norepinephrine Approved Phase 4 51-41-2 439260
48
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
49
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
50
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924

Interventional clinical trials:

(show top 50) (show all 2038)
# Name Status NCT ID Phase Drugs
1 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
2 Donepezil Treatment for Sleep Apnea Patients: A Double Blind Placebo-Controlled Study Unknown status NCT00912457 Phase 4 donepezil;placebo
3 Effect of Servo-Ventilation on CO2 Regulation and Heart Rate Variability Unknown status NCT03890939 Phase 4
4 Open, Prospective Study for the Validation of the Predictive Value of Upper Airway Segmentation and CFD Analysis on Outcome Parameters of the Mandibular Replacement Appliance (MRA) Therapy in Obstructive Sleep Apnea Hypopnea Syndrome OSAHS) Patients Unknown status NCT01524510 Phase 4
5 Cost-utility Study of CPAP Treatment in Obstructive Sleep Apnea Patients Unknown status NCT01590420 Phase 4
6 Comparison of the Pentax AWS® With the Macintosh Laryngoscope for Tracheal Intubation in Patients With Obstructive Sleep Apnea Syndrome: a Randomized Comparative Study Unknown status NCT01428570 Phase 4
7 Effects of Continuous Positive Airway Pressure (CPAP) and Nebivolol Treatment on Arterial Blood Pressure and Endothelial Function in Hypertensive OSA Patients. Unknown status NCT01771406 Phase 4 Nebivolol
8 Effect of Oxymetazoline Hydrochloride in Combination With Fluticasone Propionate on the Apnea Hypopnea Index (AHI) in Subject With Persistent Nasal Congestion and Mild Obstructive Sleep Apnea. A Double Blinded Placebo Controlled, Crossover Prospective Trial. Unknown status NCT02630121 Phase 4 Oxymetazoline Hydrochloride;Placebo
9 Effect of Treating Sleep Apnea With Oral Appliances in the Elderly: ORACLE Study Unknown status NCT02325089 Phase 4
10 Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption Unknown status NCT02371473 Phase 4 Acetazolamide-placebo;Placebo-acetazolamide
11 Adaptative Servoventilation Compliance in Left Ventricular Dysfunction Patients With Central Sleep Apnea: Benefit of One Month Hypnotic (Zopiclone) Versus Placebo Unknown status NCT02820441 Phase 4 Zopiclone;Placebo
12 Blood Pressure Reduction Induced by Continuous Positive Airway Pressure (CPAP) in Sleep Apnea Patients at High Cardiovascular Risk : A Randomized Controlled Trial Comparing Usual CPAP Care Versus a Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform Unknown status NCT01505959 Phase 4
13 Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving Continuous Positive Airway Pressure (CPAP) Compliance in Low Cardiovascular Risk Sleep Apnea Patients Unknown status NCT01796769 Phase 4
14 Effects of the Continuous Positive Airway Pressure Ventilation on the Prevalence of the Metabolic Syndrome and Cardiac Morpho-Functional Characteristics in Sleep Apnea Syndrome Unknown status NCT00517777 Phase 4
15 Long-term Effect of Nasal Continuous Positive Airway Pressure on Lipid Profile in Patients With Dyslipidaemia and Mild-moderate Obstructive Sleep Apnea Unknown status NCT02557412 Phase 4
16 The Effect of Nasal CPAP in Patients With Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
17 Sleep Disordered Breathing in TIA/Ischemic Stroke: Effects on Short- and Long-term Outcome and CPAP Treatment Efficacy: an Open, Observational, Clinical, Multicentre Trial With a Randomized Arm Unknown status NCT01097967 Phase 4
18 Inflammatory Response to Anti Inflammatory Therapy in Children With Sleep Disordered Breathing Unknown status NCT00299910 Phase 4 Montelukast
19 A Comparison Between Two Different Oral Appliance Therapies: Somnodent vs Herbst Appliance in Patients With Mild and Moderate OSA Unknown status NCT02724865 Phase 4
20 CPAP Effect on Nocturnal Evolution of Chemosensitivity Determinants in Sleep Apnea-hypopnea Patients With Isolated Nocturnal Hypertension or Day-nigh Sustained Hypertension Completed NCT02398032 Phase 4
21 Randomized, Double-blind Study to Compare Safety and Effectiveness of the ProventTM Professional Sleep Apnea Therapy Device to Sham for the Non-invasive Treatment of OSAH Completed NCT00772044 Phase 4
22 Phase 4 Study of the Relationship Between the Oxidative Stress and the Development of Cardiovascular Complications in the Sleep Apnea-hypopnea Syndrome (SAHS). Effect of the Treatment With CPAP Completed NCT00487929 Phase 4
23 The Effect of Anticholinesterase Drugs on Sleep in Alzheimer's Disease Patients Completed NCT00480870 Phase 4 donepezil;Placebo
24 Respiratory Impact of Short Life Agents Used in Balanced Anesthesia on Patients Suffering or Suspected of Obstructive Sleep Apnea (OSA) Syndrome Completed NCT02717780 Phase 4 Fentanyl and sevoflurane;Remifentanil and desflurane
25 The Effect of Trazodone on the Severity of Obstructive Sleep Apnea in Insomnic Stroke Patients With Depression Completed NCT04162743 Phase 4 Trazodone;Placebo oral tablet
26 Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome Completed NCT00603044 Phase 4 fluticasone furoate
27 Randomized, Placebo-Controlled Multicenter Trial of the Effects of Orally Administered Xyrem (Sodium Oxybate) and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients Completed NCT00086281 Phase 4 Xyrem (X);Zolpidem (Z);Modafinil (M);Placebo (P)
28 Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude Completed NCT00714740 Phase 4 acetazolamide
29 Differential Effects of Chronic Treatment of OSAS by CPAP and SOMNOsmart2 on Norepinephrine and Blood Pressure Completed NCT00633711 Phase 4
30 Does Nasal Decongestion Improve Obstructive Sleep Apnea ? Completed NCT00630474 Phase 4 xylometazoline
31 PROMAD : Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea Completed NCT01532050 Phase 4
32 Efficacy of Continuous Positive Airway Pressure (CPAP) on Blood Pressure Control of Resistant Hypertension Patients With Obstructive Sleep Apnea Syndrome (OSAS). Completed NCT01508754 Phase 4
33 Continuous Positive Airway Pressure (CPAP) and Acetazolamide for Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude Completed NCT00928655 Phase 4 acetazolamide;placebo
34 Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome (OSAS) in Children Completed NCT00912171 Phase 4 budesonide (Aircort 50 nasal spray);montelukast (Singulair)
35 Ketamine Infusion for Pediatric Patients With Obstructive Sleep Apnea Syndrome After Tonsillectomy: A Randomized Controlled Trial Completed NCT02425202 Phase 4 Ketamine
36 Nitrate and Oxidative Stress in Sleep Apnea Syndrome. Effect of Continuous Positive Airway Pressure Completed NCT00547937 Phase 4
37 Comparative Study of Effect of Valsartan 160mg Treatment Versus Continuous Positive Airway Pressure on Arterial Blood Pressure in Patients Who Have an Obstructive Sleep Apnea Syndrome and a Weak or Moderate Hypertension. Completed NCT00409487 Phase 4 Valsartant treatment
38 Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome Completed NCT00560586 Phase 4 Budesonide;placebo
39 The Endothelium Dysfunction in Patients of Obstructive Sleep Apnea Syndrome Completed NCT01699126 Phase 4 Statin
40 Prospective, Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effect of Eszoplicone on Initial Continuous Positive Airway Pressure (CPAP) Compliance Completed NCT00612157 Phase 4 Eszopiclone;Placebo control
41 A Placebo Controlled Double Blinded Crossover Study of the Antihypertensive Efficacy of Guanfacine vs Hydrochlorothiazide in Obstructive Sleep Apnea (OSA) Associated Hypertension Completed NCT02699125 Phase 4 Guanfacine;Hydrochlorothiazide
42 Effects of Continuous Positive Airway Pressure (CPAP) on Early Signs of Atherosclerosis in Patients With Obstructive Sleep Apnea: a Randomized Study Completed NCT00400543 Phase 4
43 A Double-Blind Placebo-Controlled, Randomized, Parallel-Group, Single-Site Study of Mometasone Furoate Nasal Spray (MFNS) In Subjects With Sleep-disordered Breathing Associated With Perennial Allergic Rhinitis (PAR) Using Home-Monitored Cardio-Respiratory Methodology. Completed NCT00359216 Phase 4 Mometasone furoate nasal spray;Placebo
44 Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea Before and After Treatment With CPAP. Completed NCT00360659 Phase 4
45 Pillar Palatal Implant System Multi-Institutional, Randomized Placebo-Controlled Study for Obstructive Sleep Apnea Completed NCT00307957 Phase 4
46 Efficacy of Sibutramine-induced Weight Loss vs. Continuous Positive Airway Pressure (CPAP) in the Treatment of Obese Patients With Obstructive Sleep Apnea Completed NCT00729963 Phase 4 Sibutramine
47 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF Completed NCT00551499 Phase 4
48 The Impact of Venlafaxine on Apnea Hypopnea Index in Patients With Obstructive Sleep Apnea Completed NCT02714400 Phase 4 Venlafaxine;Placebo
49 Effect of Increasing Depth of Dexmedetomidine and Propofol Anesthesia on Upper Airway Morphology in Children With History of Obstructive Sleep Apnea Completed NCT01344759 Phase 4 Dexmedetomidine;Propofol
50 Renal Hemodynamics and Tubular Function in Patients With Obstructive Sleep Apnea and Healthy Controls Completed NCT00410085 Phase 4 L-NMMA (N-mono.methyl-L-arginine)

Search NIH Clinical Center for Sleep Apnea

Cochrane evidence based reviews: sleep apnea syndromes

Sources

Genetic Tests for Sleep Apnea

About this section

Genetic tests related to Sleep Apnea:

# Genetic test Affiliating Genes
1 Sleep Apnea 29
Sources

Anatomical Context for Sleep Apnea

About this section

MalaCards organs/tissues related to Sleep Apnea:

40
Heart, Endothelial, Tongue, Brain, Liver, Kidney, Eye
Sources

Publications for Sleep Apnea

About this section

Articles related to Sleep Apnea:

(show top 50) (show all 30017)
# Title Authors PMID Year
1
Eight-Year Follow-up of Modified Uvulopalatopharyngoplasty in Patients With Obstructive Sleep Apnea. 42 61
33405253 2021
2
Mask side-effects in long-term CPAP-patients impact adherence and sleepiness: the InterfaceVent real-life study. 42
33451313 2021
3
Breathing Problems in Adults with Neuromuscular Weakness. 42
33258682 2020
4
The role of sleep endoscopy in oral appliance therapy for obstructive sleep apnea. 61
32859441 2021
5
Intervention Design and Trial Protocol: Mindfulness-based Exposure for PAP-associated Claustrophobia. 61
32443950 2021
6
Prevalence of obstructive sleep apnea at an outpatient memory clinic. 61
33474502 2021
7
Transoral Versus Endoscopic Examination in Predicting Outcomes of Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea. 61
32533788 2021
8
The novel indicators of moderate to severe sleep apnea: fibrinogen to albumin ratio vs. CRP to albumin ratio. 61
31919564 2021
9
Olfactory function in patients with obstructive sleep apnea: a meta-analysis study. 61
32914257 2021
10
Topical Collection: Sleep apnea syndrome: from the pathogenesis to the last therapies : Special Guest Editors: Manuele Casale, Rinaldi Vittorio. 61
33521851 2021
11
Screening for Obstructive Sleep Apnea in Children With Sickle Cell Disease: A Pilot Study. 61
32818314 2021
12
OCT-Angiography Comparison between Obstructive Sleep Apnea Children and Normal Subjects in China. 61
32730713 2021
13
Effects of continuous positive airway pressure on resolvin and matrix metalloproteinase-9 in patients with obstructive sleep apnea. 61
33348057 2021
14
Hypoglossal Nerve Stimulation: Outcomes in Veterans with Obstructive Sleep Apnea and Common Comorbid Post-traumatic Stress Disorder. 61
33295673 2021
15
Sleep Apnea and Atrial Fibrillation. 61
33516410 2021
16
Association between obstructive sleep apnea and non-alcoholic fatty liver disease in pediatric patients: a meta-analysis. 61
32881371 2021
17
Alternative Care Pathways for Obstructive Sleep Apnea and the Impact on Positive Airway Pressure Adherence: Unraveling the Puzzle of Adherence. 61
33485532 2021
18
Evaluation of Upper Airway in Children with Obstructive Sleep Apnea Using Cone-Beam Computed Tomography. 61
33070361 2021
19
Role of interleukin 8 in depression and other psychiatric disorders. 61
33186640 2021
20
Polycystic Ovarian Syndrome: Impact on Adult and Fetal Health. 61
33337742 2021
21
Tolerance of Continuous Positive Airway Pressure After Sinonasal Surgery. 61
32936959 2021
22
What is a Clinically Meaningful Target for Positive Airway Pressure Adherence? 61
33485522 2021
23
Intracapsular coblation tonsillectomy versus extracapsular coblation tonsillectomy: a systematic review and a meta-analysis. 61
32623507 2021
24
Predicting outcome of velopharyngeal surgery in drug-induced sleep endoscopy by traction velum. 61
32833056 2021
25
Positional awake nasoendoscopic pattern-based surgical decision for correction of retropalatal obstruction in OSA. 61
33386971 2021
26
Management of A-Frame Tracheal Deformity in Children With Endoscopic Resection Tracheoplasty. 61
33593035 2021
27
Summary and Update on Behavioral Interventions for Improving Adherence with Positive Airway Pressure Treatment in Adults. 61
33485523 2021
28
Adherence to Sleep Therapies in Children and Adolescents. 61
33485524 2021
29
Maximum isometric tongue force in patients with obstructive sleep apnoea. 61
33111155 2021
30
What Do We Know About Adherence to Oral Appliances? 61
33485526 2021
31
Considering the Role of Adherence in New and Emerging Sleep Treatments. 61
33485528 2021
32
Social Risk Factors and Atrial Fibrillation. 61
33516394 2021
33
Novel technologies in the management of heart failure with preserved ejection fraction: a promise during the time of disappointment from pharmacological approaches? 61
33394706 2021
34
Case Report: Lateral Chest Placement of IPG for Hypoglossal Nerve Stimulator Implantation. 61
32750156 2021
35
Biomarkers of Alzheimer's disease in severe obstructive sleep apnea-hypopnea syndrome in the Chinese population. 61
32303882 2021
36
Effect of Obstructive Sleep Apnea and Positive Airway Pressure Therapy on Cardiac Remodeling as Assessed by Cardiac Biomarker and Magnetic Resonance Imaging in Nonobese and Obese Adults. 61
33461313 2021
37
Sleep Duration, Sleep Timing, and Sleep Disordered Breathing-Associations With Obesity and Gestational Diabetes in Pregnancy. 61
33481418 2021
38
Sleep apnea, obesity and COPD depress respiration during catheter ablation procedures: Implications for transcutaneous carbon dioxide monitoring. 61
33152419 2021
39
Myasthenia Symptom Burden, Fatigue, and Sleep: Are They Related? 61
33595995 2021
40
Adherence to Positive Airway Pressure Therapy in Obesity Hypoventilation Syndrome. 61
33485531 2021
41
Restricted Diffusion in the Optic Nerve Head After Shock-Induced Anterior Ischemic Optic Neuropathy. 61
32028450 2021
42
Randomized Trial of 2 Self-Titrated Oral Appliances for Airway Management. 61
32942939 2021
43
Association between morningness-eveningness, sleep duration, weekend catch-up sleep and depression among Korean high-school students. 61
32391631 2021
44
Minireview: The Role of Angiotensin II in in Chronic Intermittent Hypoxia-Induced Hypertension and Cognitive Decline. 61
33595364 2021
45
Uvulopalatopharyngoplasty. 61
33581977 2021
46
The Assessment of Risk and Predictors of Sleep Disorders in Patients with Psoriasis-A Questionnaire-Based Cross-Sectional Analysis. 61
33572270 2021
47
Hepatic steatosis and respiratory diseases: a new panorama. 61
33549735 2021
48
Impact of COVID-19 Lockdown on Short-Term Results After Laparoscopic Sleeve Gastrectomy. 61
33608818 2021
49
Phenotypic variance in pediatric obstructive sleep apnea. 61
33543838 2021
50
The treatment of mild OSA with CPAP or mandibular advancement device and the effect on blood pressure and endothelial function after one year of treatment. 61
32964829 2021
Sources

Variations for Sleep Apnea

About this section

ClinVar genetic disease variations for Sleep Apnea:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 AHDC1 NM_001029882.3(AHDC1):c.2371_2372TG[1] (p.Cys791fs) Microsatellite Pathogenic 133326 rs587779766 1:27876253-27876254 1:27549742-27549743
2 AHDC1 NM_001029882.3(AHDC1):c.2898del (p.Tyr967fs) Deletion Pathogenic 133327 rs587779767 1:27875729-27875729 1:27549218-27549218
3 AHDC1 NM_001029882.3(AHDC1):c.2547del (p.Ser850fs) Deletion Pathogenic 133328 rs587779768 1:27876080-27876080 1:27549569-27549569
4 AHDC1 NM_001029882.3(AHDC1):c.2371_2372TG[1] (p.Cys791fs) Microsatellite Pathogenic 133326 rs587779766 1:27876253-27876254 1:27549742-27549743
5 AHDC1 NM_001029882.3(AHDC1):c.2898del (p.Tyr967fs) Deletion Pathogenic 133327 rs587779767 1:27875729-27875729 1:27549218-27549218
6 AHDC1 NM_001029882.3(AHDC1):c.2547del (p.Ser850fs) Deletion Pathogenic 133328 rs587779768 1:27876080-27876080 1:27549569-27549569
7 MT-CO3 NC_012920.1:m.9355A>T SNV Uncertain significance 523307 rs1556423663 MT:9355-9355 MT:9355-9355
Sources

Expression for Sleep Apnea

About this section
Search GEO for disease gene expression data for Sleep Apnea.
Sources

Pathways for Sleep Apnea

About this section

Pathways related to Sleep Apnea according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 14.12 TNF LEPR LEP INS IL6 IGF1
2
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 65
Show member pathways
 13.22 TNF NPPB LEPR LEP INS IL6
3
p70S6K Signaling 63
Show member pathways
 13.01 REN INS IL6 IGF1 HIF1A ACE
4
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 64
Show member pathways
 12.74 TNF LEP INS IL6 ADIPOQ
5
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.45 LEPR LEP INS IGF1 ADIPOQ
7
Folate Metabolism 1
Show member pathways
 12.27 TNF INS IL6 CRP APOE
8
Dilated cardiomyopathy 36
Show member pathways
 12.19 TNF IL6 IGF1 EDN1 ACE
9
Peptide hormone metabolism 65
Show member pathways
 12.17 REN LEP INS IGF1 GHRL ACE
10
MicroRNAs in cardiomyocyte hypertrophy 1
Show member pathways
 12.1 TNF NPPB IGF1 EDN1
11
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.05 TNF PHOX2B IL6 HTR2A HIF1A CXCL8
12
Spinal Cord Injury 1
11.96 TNF LEP IL6 CXCL8
13
Interleukin-4 and 13 signaling 65
11.93 TNF IL6 HIF1A CXCL8
14
HIF-1 signaling pathway 36
11.91 INS IL6 IGF1 HIF1A EDN1
15
Senescence and Autophagy in Cancer 1
11.89 INS IL6 IGF1 CXCL8
16
AGE-RAGE signaling pathway in diabetic complications 36
11.85 TNF IL6 EDN1 CXCL8
17
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.83 LEP INS IL6 IGF1 ADIPOQ
18
Pertussis 36
11.73 TNF IL6 CXCL8
19
Renin secretion 36
11.68 REN EDN1 ACE
20
HIF-1-alpha transcription factor network 1
11.65 LEP HIF1A EDN1
21
Adipocytokine signaling pathway 36
11.65 TNF LEPR LEP ADIPOQ
22
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.62 TNF IL6 CXCL8
23
Legionellosis 36
11.57 TNF IL6 CXCL8
24
ATF-2 transcription factor network 1
11.55 INS IL6 CXCL8
25
Hepatitis C and Hepatocellular Carcinoma 1
11.52 IL6 HIF1A CXCL8
26
Signaling events mediated by PTP1B 1
11.5 LEPR LEP INS
27
Malaria 36
11.5 TNF IL6 CXCL8
28
Interleukin-10 signaling 65
11.48 TNF IL6 CXCL8
29
Differentiation Pathway 1
11.46 INS IL6 IGF1
30
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.45 TNF IL6 IGF1 APOE
31
Lung fibrosis 1
11.35 TNF IL6 IGF1 EDN1 CXCL8
32
Adipogenesis 1
11.29 TNF LEP INS IL6 IGF1 HIF1A
33
Transcription factor regulation in adipogenesis 1
11.05 TNF LEP IL6 ADIPOQ
34
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.92 LEPR LEP INS GHRL
35
Overview of nanoparticle effects 1
10.84 TNF IL6 CXCL8 CRP
36
Development_Leptin signaling via JAK/STAT and MAPK cascades 23
Show member pathways
 10.83 LEPR LEP HIF1A EDN1 CRP
Sources

GO Terms for Sleep Apnea

About this section

Cellular components related to Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 TNF REN NPPB LEP INS IL6
2 extracellular region GO:0005576 9.53 TNF REN NPPB LEPR LEP INS

Biological processes related to Sleep Apnea according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Name GO ID