MCID: SLP006
MIFTS: 71

Sleep Apnea

Categories: Mental diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Sleep Apnea

MalaCards integrated aliases for Sleep Apnea:

Name: Sleep Apnea 12 54 29 6 43 15 63 17
Sleep Apnea Syndromes 44 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050847
ICD9CM 35 780.57
MeSH 44 D012891
NCIt 50 C26884
SNOMED-CT 68 73430006
ICD10 33 G47.3 G47.30
UMLS 72 C0037315

Summaries for Sleep Apnea

NINDS : 54 Sleep apnea is a common sleep disorder characterized by brief interruptions of breathing during sleep.  These episodes usually last 10 seconds or more and occur repeatedly throughout the night.  People with sleep apnea will partially awaken as they struggle to breathe, but in the morning they will not be aware of the disturbances in their sleep.  The most common type of sleep apnea is obstructive sleep apnea (OSA), caused by relaxation of soft tissue in the back of the throat that blocks the passage of air.  Central sleep apnea (CSA) is caused by irregularities in the brain’s normal signals to breathe.  Most people with sleep apnea will have a combination of both types.  The hallmark symptom of the disorder is excessive daytime sleepiness. Additional symptoms of sleep apnea include restless sleep, loud snoring (with periods of silence followed by gasps), falling asleep during the day, morning headaches, trouble concentrating, irritability, forgetfulness, mood or behavior changes, anxiety, and depression.  Not everyone who has these symptoms will have sleep apnea, but it is recommended that people who are experiencing even a few of these symptoms visit their doctor for evaluation.  Sleep apnea is more likely to occur in men than women, and in people who are overweight or obese.

MalaCards based summary : Sleep Apnea, also known as sleep apnea syndromes, is related to central sleep apnea and obesity-hypoventilation syndrome, and has symptoms including seizures, tremor and dyspnea. An important gene associated with Sleep Apnea is AHDC1 (AT-Hook DNA Binding Motif Containing 1), and among its related pathways/superpathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and AMP-activated Protein Kinase (AMPK) Signaling. The drugs Spironolactone and Dexlansoprazole have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep.

MedlinePlus : 43 Sleep apnea is a common disorder that causes your breathing to stop or get very shallow. Breathing pauses can last from a few seconds to minutes. They may occur 30 times or more an hour. The most common type is obstructive sleep apnea. It causes your airway to collapse or become blocked during sleep. Normal breathing starts again with a snort or choking sound. People with sleep apnea often snore loudly. However, not everyone who snores has sleep apnea. You are more at risk for sleep apnea if you are overweight, male, or have a family history or small airways. Children with enlarged tonsils or adenoids may also get it. Doctors diagnose sleep apnea based on medical and family histories, a physical exam, and sleep study results. When your sleep is interrupted throughout the night, you can be drowsy during the day. People with sleep apnea are at higher risk for car crashes, work-related accidents, and other medical problems. If you have it, it is important to get treatment. Lifestyle changes, mouthpieces, surgery, and breathing devices can treat sleep apnea in many people. NIH: National Heart, Lung, and Blood Institute

PubMed Health : 63 About sleep apnea: Sleep apnea (AP-ne-ah) is a common disorder in which you have one or more pauses in breathing or shallow breaths while you sleep. Breathing pauses can last from a few seconds to minutes. They may occur 30 times or more an hour. Typically, normal breathing then starts again, sometimes with a loud snort or choking sound. Sleep apnea usually is a chronic (ongoing) condition that disrupts your sleep. When your breathing pauses or becomes shallow, you’ll often move out of deep sleep and into light sleep. As a result, the quality of your sleep is poor, which makes you tired during the day. Sleep apnea is a leading cause of excessive daytime sleepiness.

Wikipedia : 75 Sleep apnea, also spelled sleep apnoea, is a sleep disorder where a person has pauses in breathing or... more...

Related Diseases for Sleep Apnea

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1026)
# Related Disease Score Top Affiliating Genes
1 central sleep apnea 35.3 NPPB NOS3 LEP
2 obesity-hypoventilation syndrome 33.6 LEP IL6 ADIPOQ
3 sleep disorder 33.2 LEP INS IL6 HCRT CRP
4 apnea, obstructive sleep 32.9 TNF REN LEP INS IL6 HTR2A
5 pulmonary disease, chronic obstructive 32.0 TNF NPPB IL6 CRP
6 congestive heart failure 31.8 REN NPPB EDN1 ACE
7 narcolepsy 31.8 TNF LEP HCRT
8 lung disease 31.7 TNF NPPB IL6 EDN1
9 end stage renal failure 31.6 TNF LEP IL6 CRP ACE
10 acromegaly 31.6 INS IGF1 GHRL
11 sexual disorder 31.5 NOS3 EDN1 ACE
12 ischemia 31.5 NOS3 ICAM1 EDN1 ACE
13 cerebral palsy 31.5 TNF IL6 APOE
14 nonarteritic anterior ischemic optic neuropathy 31.4 NOS3 EDN1 ACE
15 intermediate coronary syndrome 31.4 IL6 CRP ACE
16 lipid metabolism disorder 31.4 LEP INS CRP APOE ADIPOQ ACE
17 acute myocardial infarction 31.3 NPPB EDN1 CRP ACE
18 fatty liver disease, nonalcoholic 1 31.3 LEP INS ADIPOQ
19 coronary artery anomaly 31.3 NPPB NOS3 EDN1 CRP ACE
20 poliomyelitis 31.3 TNF LEP ICAM1
21 pulmonary hypertension 31.3 REN NPPB NOS3 EDN1 ACE
22 post-traumatic stress disorder 31.2 HTR2A CRP APOE
23 periodontitis 31.2 TNF IL6 CRP
24 vascular dementia 31.2 TNF APOE ACE
25 diabetic neuropathy 31.2 LEP INS ACE
26 fatty liver disease 31.2 TNF LEPR LEP INS IL6 ADIPOQ
27 major depressive disorder 31.2 TNF IL6 HTR2A HCRT APOE
28 peripheral vascular disease 31.2 IL6 CRP ACE
29 eclampsia 31.1 TNF REN EDN1
30 systolic heart failure 31.1 NPPB IL6 EDN1 CRP ACE
31 carotid stenosis 31.1 TNF CRP APOE ACE
32 uremia 31.1 LEP INS CRP
33 retinal vascular disease 31.1 INS ICAM1 ACE
34 peripheral artery disease 31.0 NOS3 IL6 CRP ACE
35 stroke, ischemic 31.0 REN NOS3 CRP APOE ACE
36 fibromyalgia 31.0 IL6 IGF1 HTR2A
37 adult respiratory distress syndrome 31.0 TNF IL6 ACE
38 liver disease 31.0 TNF LEPR LEP INS IL6 ADIPOQ
39 juvenile rheumatoid arthritis 31.0 TNF IL6 CRP
40 arteritic anterior ischemic optic neuropathy 30.9 NOS3 CRP ACE
41 diabetic macular edema 30.9 NOS3 IL6 ICAM1
42 spondylitis 30.8 TNF IL6 CRP CHI3L1
43 traumatic brain injury 30.8 IL6 IGF1 APOE
44 brain injury 30.8 IL6 IGF1 APOE
45 gestational diabetes 30.8 LEP INS ADIPOQ
46 diastolic heart failure 30.8 NPPB NOS3 ACE
47 complex regional pain syndrome 30.8 TNF IL6 EDN1
48 cardiogenic shock 30.7 TNF NPPB IL6
49 asthma 30.7 TNF LEP IL6 ICAM1 EDN1 CHI3L1
50 liver cirrhosis 30.7 REN LEP EDN1 ADIPOQ

Comorbidity relations with Sleep Apnea via Phenotypic Disease Network (PDN):


Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Pulmonary Hypertension, Primary, 1 Respiratory Failure

Graphical network of the top 20 diseases related to Sleep Apnea:



Diseases related to Sleep Apnea

Symptoms & Phenotypes for Sleep Apnea

UMLS symptoms related to Sleep Apnea:


seizures, tremor, dyspnea, back pain, apnea, pain, headache, syncope, excessive daytime somnolence, chronic pain, snoring, wheezing, sciatica, sleep disturbances, cheyne-stokes respiration, coughing, vertigo/dizziness, sleeplessness, labored breathing, insomnia with sleep apnea, unspecified, hypersomnia with sleep apnea, unspecified, disruption of 24 hour sleep wake cycle, unspecified

MGI Mouse Phenotypes related to Sleep Apnea:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.46 ACE ADIPOQ APOE CRP EDN1 HCRT
2 homeostasis/metabolism MP:0005376 10.43 ACE ADIPOQ APOE CRP EDN1 GHRL
3 behavior/neurological MP:0005386 10.4 ACE ADIPOQ APOE GHRL HCRT HTR2A
4 endocrine/exocrine gland MP:0005379 10.4 ACE ADIPOQ APOE EDN1 GHRL HTR2A
5 growth/size/body region MP:0005378 10.39 ACE ADIPOQ APOE EDN1 HCRT ICAM1
6 immune system MP:0005387 10.36 ACE ADIPOQ APOE CHI3L1 CRP ICAM1
7 hematopoietic system MP:0005397 10.35 ACE ADIPOQ APOE CHI3L1 ICAM1 IGF1
8 adipose tissue MP:0005375 10.34 ACE ADIPOQ APOE GHRL IGF1 IL6
9 cellular MP:0005384 10.32 ADIPOQ APOE CHI3L1 ICAM1 IGF1 IL6
10 digestive/alimentary MP:0005381 10.31 APOE EDN1 GHRL HTR2A ICAM1 IL6
11 muscle MP:0005369 10.28 ADIPOQ APOE EDN1 HCRT HTR2A ICAM1
12 mortality/aging MP:0010768 10.27 ACE ADIPOQ APOE EDN1 ICAM1 IGF1
13 nervous system MP:0003631 10.18 ADIPOQ APOE EDN1 HCRT ICAM1 IGF1
14 integument MP:0010771 10.15 ADIPOQ APOE ICAM1 IGF1 IL6 INS
15 liver/biliary system MP:0005370 10.13 ACE ADIPOQ APOE IL6 INS LEP
16 renal/urinary system MP:0005367 10.06 ACE ADIPOQ APOE EDN1 IGF1 IL6
17 neoplasm MP:0002006 10.01 ACE ADIPOQ ICAM1 IGF1 IL6 LEP
18 reproductive system MP:0005389 9.96 ACE APOE IGF1 IL6 INS LEP
19 respiratory system MP:0005388 9.81 ADIPOQ APOE HCRT IGF1 IL6 LEP
20 skeleton MP:0005390 9.7 ADIPOQ APOE EDN1 HTR2A IGF1 IL6
21 vision/eye MP:0005391 9.23 APOE ICAM1 IL6 INS LEP LEPR

Drugs & Therapeutics for Sleep Apnea

PubMed Health treatment related to Sleep Apnea: 63

Sleep apnea is treated with lifestyle changes, mouthpieces, breathing devices, and surgery. Medicines typically aren't used to treat the condition. The goals of treating sleep apnea are to: Restore regular breathing during sleepRelieve symptoms such as loud snoring and daytime sleepiness Treatment may improve other medical problems linked to sleep apnea, such as high blood pressure. Treatment also can reduce your risk for heart disease, stroke, and diabetes. If you have sleep apnea, talk with your doctor or sleep specialist about the treatment options that will work best for you. Lifestyle changes and/or mouthpieces may relieve mild sleep apnea. People who have moderate or severe sleep apnea may need breathing devices or surgery. If you continue to have daytime sleepiness despite treatment, your doctor may ask whether you're getting enough sleep. (Adults should get at least 7 to 8 hours of sleep; children and teens need more. For more information, go to the Health Topics Sleep Deprivation and Deficiency article.) If treatment and enough sleep don't relieve your daytime sleepiness, your doctor will consider other treatment options.

Drugs for Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 499)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
3
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
4
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
5
Clonidine Approved Phase 4 4205-90-7 2803
6
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
7
Phentermine Approved, Illicit Phase 4 122-09-8 4771
8
Topiramate Approved Phase 4 97240-79-4 5284627
9
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
10
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
11
Sodium citrate Approved, Investigational Phase 4 68-04-2
12
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
13
Promethazine Approved, Investigational Phase 4 60-87-7 4927
14
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
15
Adalimumab Approved Phase 4 331731-18-1 16219006
16
Zolpidem Approved Phase 4 82626-48-0 5732
17
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
18
Budesonide Approved Phase 4 51333-22-3 63006 5281004
19
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
20
Phenylephrine Approved Phase 4 59-42-7 6041
21
Pantoprazole Approved Phase 4 102625-70-7 4679
22
Testosterone enanthate Approved Phase 4 315-37-7 9416
23
Methyltestosterone Approved Phase 4 58-18-4 6010
24
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
25
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
26
Eplerenone Approved Phase 4 107724-20-9 150310 443872
27
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
28
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
29
Doxepin Approved, Investigational Phase 4 1668-19-5 667477 667468
30
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
31
Interferon beta-1b Approved Phase 4 145155-23-3
32
Lacosamide Approved Phase 4 175481-36-4, 860352-01-8 219078
33
Dutasteride Approved, Investigational Phase 4 164656-23-9 152945 6918296
34
Desflurane Approved Phase 4 57041-67-5 42113
35
Ephedrine Approved Phase 4 299-42-3 9294
36
Pseudoephedrine Approved Phase 4 90-82-4 7028
37
Liraglutide Approved Phase 4 204656-20-2 44147092
38
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
39
Levodopa Approved Phase 4 59-92-7 6047
40
Carbidopa Approved Phase 4 28860-95-9 34359
41
Finasteride Approved Phase 4 98319-26-7 57363
42
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
43
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
44
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
45
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
46
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
47
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
48
Norepinephrine Approved Phase 4 51-41-2 439260
49
Losartan Approved Phase 4 114798-26-4 3961
50
Opium Approved, Illicit Phase 4 8008-60-4

Interventional clinical trials:

(show top 50) (show all 2237)
# Name Status NCT ID Phase Drugs
1 Effects of Continuous Positive Airway Pressure (CPAP) and Nebivolol Treatment on Arterial Blood Pressure and Endothelial Function in Hypertensive OSA Patients. Unknown status NCT01771406 Phase 4 Nebivolol
2 Effects of the Continuous Positive Airway Pressure Ventilation on the Prevalence of the Metabolic Syndrome and Cardiac Morpho-Functional Characteristics in Sleep Apnea Syndrome Unknown status NCT00517777 Phase 4
3 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
4 Blood Pressure Reduction Induced by Continuous Positive Airway Pressure (CPAP) in Sleep Apnea Patients at High Cardiovascular Risk : A Randomized Controlled Trial Comparing Usual CPAP Care Versus a Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform Unknown status NCT01505959 Phase 4
5 Adaptative Servoventilation Compliance in Left Ventricular Dysfunction Patients With Central Sleep Apnea: Benefit of One Month Hypnotic (Zopiclone) Versus Placebo Unknown status NCT02820441 Phase 4 Zopiclone;Placebo
6 Donepezil Treatment for Sleep Apnea Patients: A Double Blind Placebo-Controlled Study Unknown status NCT00912457 Phase 4 donepezil;placebo
7 Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving Continuous Positive Airway Pressure (CPAP) Compliance in Low Cardiovascular Risk Sleep Apnea Patients Unknown status NCT01796769 Phase 4
8 Inflammatory Response to Anti Inflammatory Therapy in Children With Sleep Disordered Breathing Unknown status NCT00299910 Phase 4 Montelukast
9 Comparison of the Pentax AWS® With the Macintosh Laryngoscope for Tracheal Intubation in Patients With Obstructive Sleep Apnea Syndrome: a Randomized Comparative Study Unknown status NCT01428570 Phase 4
10 Open, Prospective Study for the Validation of the Predictive Value of Upper Airway Segmentation and CFD Analysis on Outcome Parameters of the Mandibular Replacement Appliance (MRA) Therapy in Obstructive Sleep Apnea Hypopnea Syndrome OSAHS) Patients Unknown status NCT01524510 Phase 4
11 PROMAD : Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea Unknown status NCT01532050 Phase 4
12 Cost-utility Study of CPAP Treatment in Obstructive Sleep Apnea Patients Unknown status NCT01590420 Phase 4
13 Auto-PAP for Pulmonary Hypertension Treatment in Decompensated Heart Failure Patients With Obstructive Sleep Apnea: A Two Center Pilot Study Unknown status NCT02963597 Phase 4
14 The Effect of Nasal CPAP in Patients With Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
15 A Placebo Controlled Double Blinded Crossover Study of the Antihypertensive Efficacy of Guanfacine vs Hydrochlorothiazide in Obstructive Sleep Apnea (OSA) Associated Hypertension Unknown status NCT02699125 Phase 4 Guanfacine;Hydrochlorothiazide
16 Sleep Disordered Breathing in TIA/Ischemic Stroke: Effects on Short- and Long-term Outcome and CPAP Treatment Efficacy: an Open, Observational, Clinical, Multicentre Trial With a Randomized Arm Unknown status NCT01097967 Phase 4
17 A Comparison Between Two Different Oral Appliance Therapies: Somnodent vs Herbst Appliance in Patients With Mild and Moderate OSA Unknown status NCT02724865 Phase 4
18 Comparing Treatment Efficacy With High and Medium Dose of Fluticasone in Combination With Salmeterol in COPD Patients Unknown status NCT01657487 Phase 4 Fluticasone/Salmeterol high dose
19 A Randomized, Double-blind, Placebo-controlled Study of Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy Unknown status NCT01328652 Phase 4 dexlansoprazole
20 Multicenter Study of Patients With Hypertension Resistant to Patient Identification and Standardization of Therapeutic Unknown status NCT01643434 Phase 4 Spironolactone;Clonidine
21 Impact of the Preservation of the Gastric Antrum in the Technique of Sleeve Gastrectomy for the Treatment of the Morbid Obesity: a Prospective,Controlled, Randomized, Multicentrique Study. Unknown status NCT01550601 Phase 4
22 Pilot Study: The Effect of Rozerem on Sleep Disturbance After Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
23 Behavior and Exercise Versus Drug Treatment in Men With Nocturia Unknown status NCT00824200 Phase 4 tamsulosin (alpha-adrenergic antagonist medication);placebo
24 Prospective Randomized Equivalence Trial Comparing the Analgesic Efficacy of Ofirmev® Compared to a 1.5 Gram Dose of Oral Acetaminophen for Arthroscopic Rotator Cuff Repair Unknown status NCT01711229 Phase 4 IV acetaminophen;oral acetaminophen
25 Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea Before and After Treatment With CPAP. Completed NCT00360659 Phase 4
26 Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude Completed NCT00714740 Phase 4 acetazolamide
27 Cardiovascular Impact of Obstructive Sleep Apnea in Normotensive Patients and the Effects of Continuous Positive Airway Pressure Completed NCT00741520 Phase 4
28 Respiratory Impact of Short Life Agents Used in Balanced Anesthesia on Patients Suffering or Suspected of Obstructive Sleep Apnea (OSA) Syndrome Completed NCT02717780 Phase 4 Fentanyl and sevoflurane;Remifentanil and desflurane
29 Does Nasal Decongestion Improve Obstructive Sleep Apnea ? Completed NCT00630474 Phase 4 xylometazoline
30 Continuous Positive Airway Pressure (CPAP) and Acetazolamide for Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude Completed NCT00928655 Phase 4 acetazolamide;placebo
31 Efficacy of Sibutramine-induced Weight Loss vs. Continuous Positive Airway Pressure (CPAP) in the Treatment of Obese Patients With Obstructive Sleep Apnea Completed NCT00729963 Phase 4 Sibutramine
32 Serotonin and the Upper Airway in Obstructive Sleep Apnea Completed NCT00100464 Phase 4 Paroxetine;5HTP
33 Randomized, Double-blind Study to Compare Safety and Effectiveness of the ProventTM Professional Sleep Apnea Therapy Device to Sham for the Non-invasive Treatment of OSAH Completed NCT00772044 Phase 4
34 Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome With Major Depressive Disorder or Dysthymic Disorder Completed NCT00518986 Phase 4 armodafinil;placebo
35 CPAP Effect on Nocturnal Evolution of Chemosensitivity Determinants in Sleep Apnea-hypopnea Patients With Isolated Nocturnal Hypertension or Day-nigh Sustained Hypertension Completed NCT02398032 Phase 4
36 Effect Of Nasal CPAP On Glycemic Control In Patients With Poorly Controlled Type 2 Diabetes And Sleep Apnea-Hypopnea Syndrome Completed NCT01801150 Phase 4
37 Effect of CPAP on Arterial Hypertension and Cardiovascular Morbi-Mortality in Patients With Sleep Apnea and Without Daytime Sleepiness Completed NCT00127348 Phase 4
38 Efficacy and Safety of Adalimumab in Patients With Psoriasis and Obstructive Sleep Apnea Completed NCT01181570 Phase 4 Adalimumab;Placebo
39 Randomized, Placebo-Controlled Multicenter Trial of the Effects of Orally Administered Xyrem (Sodium Oxybate) and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients Completed NCT00086281 Phase 4 Xyrem (X);Zolpidem (Z);Modafinil (M);Placebo (P)
40 Efficacy of Continuous Positive Airway Pressure (CPAP) on Blood Pressure Control of Resistant Hypertension Patients With Obstructive Sleep Apnea Syndrome (OSAS). Completed NCT01508754 Phase 4
41 Nitrate and Oxidative Stress in Sleep Apnea Syndrome. Effect of Continuous Positive Airway Pressure Completed NCT00547937 Phase 4
42 The Effect of Sodium-Restricted Diet and Diuretic in the Severe Sleep Apnea: a Randomized Controlled Trial - DESALT Study Completed NCT01945801 Phase 4 Lasilactone;Placebo
43 Ketamine Infusion for Pediatric Patients With Obstructive Sleep Apnea Syndrome After Tonsillectomy: A Randomized Controlled Trial Completed NCT02425202 Phase 4 Ketamine
44 Pillar Palatal Implant System Multi-Institutional, Randomized Placebo-Controlled Study for Obstructive Sleep Apnea Completed NCT00307957 Phase 4
45 Obstructive Sleep Apnea in the Absence of Metabolic Syndrome: Pulse Wave Velocity, Inflammatory and Oxidative Stress Markers Completed NCT01635010 Phase 4
46 Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome Completed NCT00603044 Phase 4 fluticasone furoate
47 Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome (OSAS) in Children Completed NCT00912171 Phase 4 budesonide (Aircort 50 nasal spray);montelukast (Singulair)
48 Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in ICD Patients Completed NCT00708786 Phase 4
49 Renal Hemodynamics and Tubular Function in Patients With Obstructive Sleep Apnea and Healthy Controls Completed NCT00410085 Phase 4 L-NMMA (N-mono.methyl-L-arginine)
50 Prospective, Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effect of Eszoplicone on Initial Continuous Positive Airway Pressure (CPAP) Compliance Completed NCT00612157 Phase 4 Eszopiclone;Placebo control

Search NIH Clinical Center for Sleep Apnea

Cochrane evidence based reviews: sleep apnea syndromes

Genetic Tests for Sleep Apnea

Genetic tests related to Sleep Apnea:

# Genetic test Affiliating Genes
1 Sleep Apnea 29

Anatomical Context for Sleep Apnea

MalaCards organs/tissues related to Sleep Apnea:

41
Heart, Testes, Endothelial, Tongue, Brain, Lung, Kidney

Publications for Sleep Apnea

Articles related to Sleep Apnea:

(show top 50) (show all 28333)
# Title Authors PMID Year
1
Effects of continuous positive airway pressure (CPAP) therapy on neurological and functional rehabilitation in Basal Ganglia Stroke patients with obstructive sleep apnea: A prospective multicenter study. 38 17
31305423 2019
2
Towards Patient-centered Diagnosis of Pediatric Obstructive Sleep Apnea-A Review of Biomedical Engineering Strategies. 38 17
31159603 2019
3
Eyelid laxity and sleep apnea syndrome: a review. 38 17
31198891 2019
4
Ballistocardiogram signal processing: a review. 38
31114676 2019
5
Overexpressed long noncoding RNA CPS1-IT alleviates pulmonary arterial hypertension in obstructive sleep apnea by reducing interleukin-1β expression via HIF1 transcriptional activity. 38
30982984 2019
6
Rhomboid Intercostal and Subserratus Plane block for modified radical mastectomy and axillary curettage in a patient with severe obstructive sleep apnea and morbid obesity. 38
30933855 2019
7
Exposure to different intrauterine environments: implications for telomere attrition in early life. 38
29681194 2019
8
Normalization of breathing with adenotonsillectomy in Japanese pediatric OSA. 38
30799139 2019
9
Single versus double suspension sutures for selected cases of obstructive sleep apnea. 38
30626548 2019
10
Association between inflammatory potential of the diet and sleep parameters in sleep apnea patients. 38
31177057 2019
11
Comparison between auto-trilevel and bilevel positive airway pressure ventilation for treatment of patients with concurrent obesity hypoventilation syndrome and obstructive sleep apnea syndrome. 38
30426457 2019
12
Self-reported snoring and incident cardiovascular disease events: results from the Jackson Heart Study. 38
30756321 2019
13
Thoracic Manifestations of Ankylosing Spondylitis, Inflammatory Bowel Disease, and Relapsing Polychondritis. 38
31376894 2019
14
Posterior segment assessment in patients with obstructive sleep apnea syndrome. 38
30949928 2019
15
A novel intermittent negative air pressure device ameliorates obstructive sleep apnea syndrome in adults. 38
30690676 2019
16
The association between obstructive sleep apnea syndrome and metabolic syndrome: a confirmatory factor analysis. 38
30820851 2019
17
Sex differences in mandibular repositioning device therapy effectiveness in patients with obstructive sleep apnea syndrome. 38
30580418 2019
18
Successful upper airway stimulation therapy in an adult Down syndrome patient with severe obstructive sleep apnea. 38
30430373 2019
19
Obstructive Sleep Apnea in Neuro-Ophthalmology. 38
30300256 2019
20
The effect of continuous positive airway pressure (CPAP) treatment on serum levels of proBDNF and mature BDNF in patients with obstructive sleep apnea. 38
30498925 2019
21
Inducers of post-apneic blood pressure fluctuation monitored by pulse transfer time measurement in obstructive sleep apnea varied with syndrome severity. 38
30637570 2019
22
Psychometric properties of the Ethos Brief Index (EBI) using factorial structure and Rasch Analysis among patients with obstructive sleep apnea before and after CPAP treatment is initiated. 38
30523558 2019
23
Application of Neck Circumference in Four-Variable Screening Tool for Early Prediction of Obstructive Sleep Apnea in Acute Ischemic Stroke Patients. 38
31296477 2019
24
A Couples-Oriented Intervention for Positive Airway Pressure Therapy Adherence: A Pilot Study of Obstructive Sleep Apnea Patients and Their Partners. 38
29388827 2019
25
Stroke Volume Predicts Nocturnal Hypoxemia in the Acute Ischemic Stroke after Intravenous Thrombolysis. 38
31277996 2019
26
Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder. 38
31238203 2019
27
Factors Influencing Sleep Difficulty and Sleep Quantity in the Citizen Pscientist Psoriatic Cohort. 38
31177381 2019
28
The estimation of excessive daytime sleepiness in post-stroke patients - a polysomnographic study. 38
31136826 2019
29
Precision Medicine for Obstructive Sleep Apnea. 38
31375207 2019
30
Further Development of P4 Approach to Obstructive Sleep Apnea. 38
31375206 2019
31
Obstructive sleep apnea severity and subsequent risk for cancer incidence. 38
31193286 2019
32
MRI-based methodology to monitor the impact of positional changes on the airway caliber in obstructive sleep apnea patients. 38
31150812 2019
33
Lack of associations between thyroid function and obstructive sleep apnea severity in adults with prediabetes and diabetes mellitus. 38
30456738 2019
34
The association between obstructive sleep apnea during REM sleep and autonomic dysfunction as measured by heart rate variability. 38
30685848 2019
35
Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA). 38
30467691 2019
36
Measurement of fractional exhaled nitric oxide and nasal nitric oxide in male patients with obstructive sleep apnea. 38
30542936 2019
37
Perioperative complications in patients with sleep apnea following primary total shoulder arthroplasty: An analysis of 33,366 patients. 38
31110398 2019
38
Expression profile of long non-coding RNAs in rat models of OSA-induced cardiovascular disease: new insight into pathogenesis. 38
30535531 2019
39
The Swiss Narcolepsy Scale (SNS) and its short form (sSNS) for the discrimination of narcolepsy in patients with hypersomnolence: a cohort study based on the Bern Sleep-Wake Database. 38
31127382 2019
40
The utility of current criteria for split-night polysomnography for predicting CPAP eligibility. 38
30397738 2019
41
[Arterial hypertension and renal denervation : fantasy or reality ?] 38
31070325 2019
42
Postoperative Respiratory Depression May Be Related to Undiagnosed Sleep-Disordered Breathing or Obstructive Sleep Apnea. 38
31425241 2019
43
Obstructive Sleep Apnea and Perioperative Outcomes: We Should Not Confuse the Probability With the Established Diagnosis. 38
31425244 2019
44
A validation study on three screening questionnaires for obstructive sleep apnea in a Korean community sample. 38
30448963 2019
45
A false alarm of narcolepsy: obstructive sleep apnea masquerading as narcolepsy and depression. 38
30523556 2019
46
Short-term effects of continuous positive airway pressure on oxidative stress in severe sleep apnea. 38
30685847 2019
47
Benefit of continuous positive airway pressure on work quality in patients with severe obstructive sleep apnea. 38
30685849 2019
48
High risk of obstructive sleep apnea, insomnia, and daytime sleepiness among commercial motor vehicle drivers. 38
30805834 2019
49
Utility of transthoracic impedance and novel algorithm for sleep apnea screening in pacemaker patient. 38
30470999 2019
50
Comparative assessment of drug-induced sleep endoscopy scoring systems in pediatric sleep apnea. 38
30671952 2019

Variations for Sleep Apnea

ClinVar genetic disease variations for Sleep Apnea:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 AHDC1 NM_001029882.3(AHDC1): c.2371_2372TG[1] (p.Cys791fs) short repeat Pathogenic rs587779766 1:27876253-27876254 1:27549742-27549743
2 AHDC1 NM_001029882.3(AHDC1): c.2898del (p.Tyr967fs) deletion Pathogenic rs587779767 1:27875729-27875729 1:27549218-27549218
3 AHDC1 NM_001029882.3(AHDC1): c.2547del (p.Ser850fs) deletion Pathogenic rs587779768 1:27876080-27876080 1:27549569-27549569
4 46;XX;t(2;11)(q11.2;p13)dn Translocation Pathogenic
5 MT-CO3 NC_012920.1: m.9355A> T single nucleotide variant Uncertain significance rs1556423663 MT:9355-9355 MT:9355-9355

Expression for Sleep Apnea

Search GEO for disease gene expression data for Sleep Apnea.

Pathways for Sleep Apnea

Pathways related to Sleep Apnea according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 TNF LEP INS IL6 ADIPOQ
2
Show member pathways
12.32 LEPR LEP INS IGF1 ADIPOQ
4
Show member pathways
12.19 TNF IL6 IGF1 ACE
5
Show member pathways
12.13 TNF INS IL6 ICAM1 CRP APOE
6
Show member pathways
12.08 TNF NPPB IGF1 EDN1
7 12.01 TNF NOS3 ICAM1 EDN1
8 11.93 TNF LEP IL6 ICAM1
9 11.89 TNF IL6 ICAM1 EDN1
10
Show member pathways
11.89 REN LEP INS IGF1 GHRL ACE
11
Show member pathways
11.87 TNF NOS3 INS IL6
12 11.84 NOS3 INS IL6 IGF1 EDN1
13 11.79 TNF IL6 ICAM1
14 11.77 TNF NOS3 IL6 ICAM1 EDN1
15 11.66 TNF IL6 IGF1
16 11.62 TNF LEPR LEP ADIPOQ
17
Show member pathways
11.6 TNF IL6 ICAM1
18 11.56 TNF IL6 IGF1 EDN1
19 11.49 LEPR LEP INS
20 11.47 TNF IL6 ICAM1
21 11.46 TNF IL6 ICAM1
22 11.45 INS IL6 IGF1
23 11.44 TNF IL6 ICAM1
24 11.39 TNF IL6 IGF1 APOE
25 11.3 TNF IL6 ICAM1
26 11.22 TNF LEP INS IL6 IGF1 ADIPOQ
27
Show member pathways
11.03 LEPR LEP EDN1 CRP
28 10.95 TNF IL6 CRP
29 10.6 TNF LEP IL6 ADIPOQ

GO Terms for Sleep Apnea

Cellular components related to Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 TNF REN NPPB LEPR LEP INS
2 extracellular space GO:0005615 9.5 TNF REN NPPB LEP INS IL6

Biological processes related to Sleep Apnea according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 TNF NOS3 INS IL6 IGF1 CRP
2 response to hypoxia GO:0001666 9.97 LEP ICAM1 EDN1 ADIPOQ
3 positive regulation of protein kinase B signaling GO:0051897 9.96 TNF LEP INS CHI3L1
4 response to lipopolysaccharide GO:0032496 9.96 REN NOS3 ICAM1 EDN1
5 negative regulation of gene expression GO:0010629 9.95 TNF IGF1 EDN1 APOE ACE
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.94 HTR2A HCRT GHRL EDN1
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 TNF INS IL6 ICAM1
8 cholesterol metabolic process GO:0008203 9.91 LEPR LEP APOE
9 cellular response to interleukin-1 GO:0071347 9.91 ICAM1 EDN1 CHI3L1
10 positive regulation of MAPK cascade GO:0043410 9.9 LEP INS IL6 IGF1
11 cartilage development GO:0051216 9.89 GHRL EDN1 CHI3L1
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 LEP IL6 IGF1
13 response to glucocorticoid GO:0051384 9.88 TNF IL6 ADIPOQ
14 cellular response to drug GO:0035690 9.87 REN EDN1 ADIPOQ
15 positive regulation of MAP kinase activity GO:0043406 9.87 TNF HTR2A EDN1
16 response to nutrient levels GO:0031667 9.86 LEP GHRL ADIPOQ
17 glucose homeostasis GO:0042593 9.86 LEPR LEP INS ADIPOQ
18 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.83 TNF IGF1 EDN1
19 negative regulation of fat cell differentiation GO:0045599 9.83 TNF IL6 ADIPOQ
20 response to activity GO:0014823 9.81 LEP EDN1 ADIPOQ
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 TNF ICAM1 EDN1
22 negative regulation of endothelial cell proliferation GO:0001937 9.78 TNF GHRL APOE
23 acute-phase response GO:0006953 9.77 INS IL6 CRP
24 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.76 TNF LEP INS IGF1
25 positive regulation of glucose import GO:0046326 9.75 INS IGF1 ADIPOQ
26 regulation of protein secretion GO:0050708 9.74 TNF INS
27 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.74 CRP ADIPOQ
28 phosphatidylinositol 3-kinase signaling GO:0014065 9.74 IGF1 HTR2A EDN1
29 response to dietary excess GO:0002021 9.73 LEP APOE
30 sexual reproduction GO:0019953 9.73 LEPR LEP
31 response to leptin GO:0044321 9.73 LEPR EDN1
32 negative regulation of hormone secretion GO:0046888 9.73 EDN1 ADIPOQ
33 angiotensin maturation GO:0002003 9.72 REN ACE
34 negative regulation of blood vessel diameter GO:0097756 9.72 INS CRP
35 artery smooth muscle contraction GO:0014824 9.72 HTR2A EDN1
36 adult feeding behavior GO:0008343 9.72 LEP GHRL
37 positive regulation of cold-induced thermogenesis GO:0120162 9.72 LEPR LEP HCRT GHRL ADIPOQ
38 negative regulation of smooth muscle cell apoptotic process GO:0034392 9.71 IGF1 EDN1
39 negative regulation of platelet activation GO:0010544 9.71 NOS3 APOE
40 leptin-mediated signaling pathway GO:0033210 9.71 LEPR LEP
41 body fluid secretion GO:0007589 9.71 NPPB EDN1
42 positive regulation of mitotic nuclear division GO:0045840 9.71 INS IGF1 EDN1
43 positive regulation of smooth muscle cell proliferation GO:0048661 9.71 TNF IL6 IGF1 EDN1
44 ovulation from ovarian follicle GO:0001542 9.7 NOS3 LEP
45 neutrophil mediated immunity GO:0002446 9.69 IL6 ACE
46 negative regulation of hydrolase activity GO:0051346 9.69 NOS3 LEPR
47 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.68 NOS3 EDN1
48 regulation of bone remodeling GO:0046850 9.68 LEPR LEP
49 positive regulation of neuroinflammatory response GO:0150078 9.68 TNF IL6
50 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.67 TNF ICAM1

Molecular functions related to Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.56 TNF IL6 EDN1 ADIPOQ
2 signaling receptor binding GO:0005102 9.55 REN NPPB LEP EDN1 ADIPOQ
3 hormone activity GO:0005179 9.17 NPPB LEP INS IGF1 GHRL EDN1
4 insulin-like growth factor receptor binding GO:0005159 9.13 REN INS IGF1

Sources for Sleep Apnea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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