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MCID: SLP005
MIFTS: 60

Sleep Disorder

Categories: Mental diseases, Neuronal diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Sleep Disorder

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MalaCards integrated aliases for Sleep Disorder:

Name: Sleep Disorder 12 15 17
Non-Organic Sleep Disorder 12 74
Sleep Disorders 44 74

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:535
ICD9CM 36 307.4
ICD10 34 F51 G47 G47.9
Sources

Summaries for Sleep Disorder

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MedlinePlus : 44 What is sleep? Sleep is a complex biological process. While you are sleeping, you are unconscious, but your brain and body functions are still active. They are doing a number of important jobs that help you stay healthy and function at your best. So when you don't get enough quality sleep, it does more than just make you feel tired. It can affect your physical and mental health, thinking, and daily functioning. What are sleep disorders? Sleep disorders are conditions that disturb your normal sleep patterns. There are more than 80 different sleep disorders. Some major types include Insomnia - being unable to fall asleep and stay asleep. This is the most common sleep disorder. Sleep apnea - a breathing disorder in which you stop breathing for 10 seconds or more during sleep Restless leg syndrome (RLS) - a tingling or prickly sensation in your legs, along with a powerful urge to move them Hypersomnia - being unable to stay awake during the day. This includes narcolepsy, which causes extreme daytime sleepiness. Circadian rhythm disorders - problems with the sleep-wake cycle. They make you unable to sleep and wake at the right times. Parasomnia - acting in unusual ways while falling asleep, sleeping, or waking from sleep, such as walking, talking, or eating Some people who feel tired during the day have a true sleep disorder. But for others, the real problem is not allowing enough time for sleep. It's important to get enough sleep every night. The amount of sleep you need depends on several factors, including your age, lifestyle, health, and whether you have been getting enough sleep recently. Most adults need about 7-8 hours each night. What causes sleep disorders? There are different causes for different sleep disorders, including Other conditions, such as heart disease, lung disease, nerve disorders, and pain Mental illnesses, including depression and anxiety Medicines Genetics Sometimes the cause is not known. There are also some factors that can contribute to sleep problems, including Caffeine and alcohol An irregular schedule, such as working the night shift Aging. As people age, they often get less sleep or spend less time in the deep, restful stage of sleep. They are also more easily awakened. What are the symptoms of sleep disorders? The symptoms of sleep disorders depend on the specific disorder. Some signs that you may have a sleep disorder include that You regularly take more than 30 minutes each night to fall asleep You regularly wake up several times each night and then have trouble falling back to sleep, or you wake up too early in the morning You often feel sleepy during the day, take frequent naps, or fall asleep at the wrong times during the day Your bed partner says that when you sleep, you snore loudly, snort, gasp, make choking sounds, or stop breathing for short periods You have creeping, tingling, or crawling feelings in your legs or arms that are relieved by moving or massaging them, especially in the evening and when trying to fall asleep Your bed partner notices that your legs or arms jerk often during sleep You have vivid, dreamlike experiences while falling asleep or dozing You have episodes of sudden muscle weakness when you are angry or fearful, or when you laugh You feel as though you cannot move when you first wake up How are sleep disorders diagnosed? To make a diagnosis, your health care provider will use your medical history, your sleep history, and a physical exam. You may also have a sleep study (polysomnogram). The most common types of sleep studies monitor and record data about your body during a full night of sleep. The data includes Brain wave changes Eye movements Breathing rate Blood pressure Heart rate and electrical activity of the heart and other muscles Other types of sleep studies may check how quickly you fall asleep during daytime naps or whether you are able to stay awake and alert during the day. What are the treatments for sleep disorders? Treatments for sleep disorders depend on which disorder you have. They may include Good sleep habits and other lifestyle changes, such as a healthy diet and exercise Cognitive behavioral therapy or relaxation techniques to reduce anxiety about getting enough sleep CPAP (continuous positive airway pressure) machine for sleep apnea Bright light therapy (in the morning) Medicines, including sleeping pills. Usually, providers recommend that you use sleeping pills for a short period of time. Natural products, such as melatonin. These products may help some people, but are generally for short-term use. Make sure to check with your health care provider before you take any of them.

MalaCards based summary : Sleep Disorder, also known as non-organic sleep disorder, is related to advanced sleep phase syndrome and sleep apnea, and has symptoms including seizures, tremor and fever. An important gene associated with Sleep Disorder is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are Circadian rythm related genes and Circadian rhythm. The drugs Esomeprazole and Apomorphine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related phenotypes are Decreased human papilloma virus 16 (HPV16) pseudovirus infection and behavior/neurological

Disease Ontology : 12 A disease of mental health that involves disruption of sleep patterns.

Wikipedia : 77 A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal. ... more...

Sources

Related Diseases for Sleep Disorder

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Diseases related to Sleep Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 397)
# Related Disease Score Top Affiliating Genes
1 advanced sleep phase syndrome 32.8 HCRT PER2 PER3
2 sleep apnea 32.6 CRP HCRT LEP
3 delayed sleep phase disorder 32.5 CRY1 PER2 PER3
4 narcolepsy 1 32.5 HCRT MOG
5 narcolepsy 31.9 HCRT HCRTR1 HCRTR2 LEP MOG
6 periodic limb movement disorder 31.6 CTNNBL1 FXYD1
7 cluster headache 30.2 HCRTR2 PRL
8 disease of mental health 29.9 HCRT MAPT NPS
9 rohhad 29.8 HCRT HCRTR1 HCRTR2
10 apnea, obstructive sleep 28.8 ARIH1 CRP CTNNBL1 FXYD1 HCRT LEP
11 non 24 hour sleep wake disorder 12.0
12 idiopathic hypersomnia 11.5
13 recurrent hypersomnia 11.4
14 rem sleep behavior disorder 11.3
15 machado-joseph disease 11.3
16 kleine-levin hibernation syndrome 11.2
17 bruxism 11.2
18 hypersomnia 11.1
19 migraine with or without aura 1 11.1
20 advanced sleep phase syndrome, familial, 1 11.1
21 creutzfeldt-jakob disease 11.1
22 short sleeper 10.9
23 neurodevelopmental disorder with severe motor impairment and absent language 10.9
24 dementia, lewy body 10.8
25 progeroid short stature with pigmented nevi 10.8
26 brunner syndrome 10.8
27 chromosome 1q21.1 deletion syndrome, 1.35-mb 10.8
28 narcolepsy 7 10.8
29 mental retardation, autosomal recessive 37 10.8
30 lyme disease - neurological complications 10.8
31 rere-related disorders 10.4
32 congestive heart failure 10.3
33 depression 10.3
34 central hypoventilation syndrome, congenital 10.2
35 epilepsy 10.2
36 panencephalitis, subacute sclerosing 10.2 MAPT MOG
37 neuromuscular disease 10.2
38 down syndrome 10.2
39 prader-willi syndrome 10.2
40 multiple system atrophy 1 10.2
41 restless legs syndrome 10.2
42 rhinitis 10.2
43 attention deficit-hyperactivity disorder 10.1
44 anxiety 10.1
45 diabetes mellitus 10.1
46 pol iii-related leukodystrophies 10.1
47 allergic rhinitis 10.1
48 fibromyalgia 10.1
49 anovulation 10.1 CRP LEP PRL
50 anorexia nervosa 10.1 HCRT LEP PRL

Graphical network of the top 20 diseases related to Sleep Disorder:



Diseases related to Sleep Disorder
Sources

Symptoms & Phenotypes for Sleep Disorder

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UMLS symptoms related to Sleep Disorder:


seizures, tremor, fever, dyspnea, edema, back pain, cachexia, vertigo, pain, headache, syncope, cyanosis, snoring, chronic pain, sciatica, sleep disturbances, icterus, signs and symptoms, signs and symptoms, digestive, hot flushes, vertigo/dizziness, sleeplessness, nervousness, psychiatric symptom, sluggishness, nightmares, hallucinations, hypnagogic

GenomeRNAi Phenotypes related to Sleep Disorder according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human papilloma virus 16 (HPV16) pseudovirus infection GR00306-A 9.1 ADORA1 CTNNBL1 FXYD1 HAPLN1 HCRTR1 PRL

MGI Mouse Phenotypes related to Sleep Disorder:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 ADORA1 ANK3 CRY1 HAPLN1 HCRT HCRTR1
2 cardiovascular system MP:0005385 9.81 ADORA1 CRP CRY1 FXYD1 HCRT LEP
3 muscle MP:0005369 9.56 CRY1 FXYD1 HCRT HCRTR2 LEP MAPT
4 nervous system MP:0003631 9.4 ADORA1 ANK3 CRY1 HCRT HCRTR1 HCRTR2
Sources

Drugs & Therapeutics for Sleep Disorder

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Drugs for Sleep Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 987)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Esomeprazole Approved, Investigational Phase 4,Phase 3 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
2
Apomorphine Approved, Investigational Phase 4 58-00-4, 41372-20-7 6005
3
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 62-31-7, 51-61-6 681
4
Clonidine Approved Phase 4,Phase 2,Not Applicable 4205-90-7 2803
5
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 27203-92-5 33741
6
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 6740-88-1 3821
7
Parathyroid hormone Approved, Investigational Phase 4,Phase 2,Not Applicable 9002-64-6
8
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 60142-96-3 3446
9
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 64-17-5 702
10
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 57-27-2 5288826
11
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
12
Levetiracetam Approved, Investigational Phase 4,Phase 3,Phase 2 102767-28-2 441341
13
Clonazepam Approved, Illicit Phase 4,Phase 2,Not Applicable 1622-61-3 2802
14
Norepinephrine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 51-41-2 439260
15
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 51-84-3 187
16
Zolpidem Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 82626-48-0 5732
17
Diphenhydramine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 147-24-0, 58-73-1 3100
18
Promethazine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 60-87-7 4927
19
Trazodone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 19794-93-5 5533
20
Ropinirole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 91374-20-8, 91374-21-9 5095 497540
21
Pramipexole Approved, Investigational Phase 4,Phase 3,Phase 2 104632-26-0 119570 59868
22
Imipramine Approved Phase 4,Phase 3 50-49-7 3696
23
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 148553-50-8 5486971
24
Dexlansoprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 138530-94-6, 103577-45-3 9578005
25
Lansoprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 103577-45-3 3883
26
Zopiclone Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 43200-80-2 5735
27
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
28
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
29
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
30
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1401-55-4
31
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
32
Citalopram Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 59729-33-8 2771
33
Eszopiclone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 138729-47-2 969472
34
Donepezil Approved Phase 4,Phase 2,Phase 1 120014-06-4 3152
35
Montelukast Approved Phase 4,Phase 3,Phase 2,Not Applicable 158966-92-8 5281040
36
Efavirenz Approved, Investigational Phase 4,Phase 3,Not Applicable 154598-52-4 64139
37
mometasone furoate Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 83919-23-7
38
Acetazolamide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-66-5 1986
39
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 51-45-6 774
40
Modafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 68693-11-8 4236
41
Allopurinol Approved Phase 4,Phase 2,Not Applicable 315-30-0 2094
42
Lithium carbonate Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 554-13-2
43
Valproic Acid Approved, Investigational Phase 4,Phase 1,Phase 2 99-66-1 3121
44
Sertraline Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 79617-96-2 68617
45
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 61869-08-7 43815
46
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 52485-79-7 644073 40400
47
Methylphenidate Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 113-45-1 4158
48
Estazolam Approved, Illicit Phase 4,Phase 3 29975-16-4 3261
49
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 54910-89-3 3386
50
Sodium oxybate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 502-85-2 5360545

Interventional clinical trials:

(show top 50) (show all 4780)
# Name Status NCT ID Phase Drugs
1 Sleep Disturbances in Hospitalized Children Unknown status NCT00749814 Phase 4
2 Esomeprazole Plus Alginate vs. Esomeprazole Alone for Treatment of Nighttime Reflux Symptom and Sleep Disturbances Unknown status NCT02277886 Phase 4 sodium alginate;esomeprazole
3 Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease Unknown status NCT02768077 Phase 4 Melatonin(Circadin®);Placebo
4 Effect of Continuous Apomorphine During the Night on Sleep Disorders in Insomniac Patients With Parkinson's Disease Unknown status NCT02940912 Phase 4 Apomorphine;Placebo
5 Effect of Rozerem on Sleep Among People With Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
6 Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD Unknown status NCT00152750 Phase 4 APO-clonidine
7 Comparison of Peritonsillar Infiltration of Tramadol Ketamine and Placebo on Pediatric Posttonsillectomy Pain Unknown status NCT03067103 Phase 4 Tramadol;Ketamine;Placebos
8 Somnodent vs Herbst in Mild and Moderate OSA Patients Unknown status NCT02724865 Phase 4
9 Cholecalciferol Supplementation in Restless Leg Syndrome in Patients With Chronic Kidney Disease Unknown status NCT03063190 Phase 4 Vitamin D;Placebo Oral Tablet
10 Treatment for Alcohol Dependence With Gabapentin Unknown status NCT02771925 Phase 4 Gabapentin 2g/day divided in two doses for 24 weeks;Placebo 2g/day divided in two doses for 24 weeks
11 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
12 Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
13 Are Patients Suffering From DSPS Show Compromising in Everyday Functions and Abilities Before Handling the Disorder? Unknown status NCT02962037 Phase 4
14 Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status Unknown status NCT02135055 Phase 4 Midazolam;Morphine
15 Levetiracetam Treatment of Children With Subclinical Sleep-Activated Epileptiform Activity (SSEA) Unknown status NCT00393614 Phase 4 levetiracetam
16 Neurochemical, Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder Unknown status NCT02346682 Phase 4 venlafaxine
17 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
18 Effect of Slow-release Melatonin (Circadin®) Therapy on Idiopathic RBD: a Pilot Study Unknown status NCT02836743 Phase 4 Circadin;Placebo
19 Bioboosti Device for Insomnia Treatment Unknown status NCT02924116 Phase 4
20 Efficacy and Safety of 5 mg Sublingual Zolpidem vs 10mg Oral Zolpidem in the Induction and Maintenance of Sleep in Patients With Primary Insomnia Unknown status NCT01896336 Phase 4 Zolpidem Hemitartrate
21 Sequenced Therapies for Comorbid and Primary Insomnias Unknown status NCT01651442 Phase 4 Zolpidem;Trazodone
22 Effects of Ramelteon (8mg) Alone and in Combination With Multi-Component Behavioral Therapy on Sleep and Circadian Phase in Patients With Chronic Insomnia Unknown status NCT01180855 Phase 4 Placebo;Rozerem 8mg
23 Study to Observe the Effect of Mirapex ER® Once-daily (QD) Versus Twice-daily (BID) Unknown status NCT01515774 Phase 4 Mirapex ER
24 Clinical Trial to Evaluate the Efficacy of FITOGYN Versus Placebo on the Vasomotor Symptomatology Associated With Menopause Unknown status NCT01116310 Phase 4 Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L);Placebo
25 Imipramine and Pregabalin Combination in Painful Polyneuropathy Unknown status NCT01047488 Phase 4 Imipramine;Pregabalin;Imipramine, pregabalin;Placebo
26 Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy Unknown status NCT01328652 Phase 4 dexlansoprazole
27 Effects of Gabapentin Enacarbil on Arousals, Heart Rate, Blood Pressure and PLMs in Restless Legs Syndrome Unknown status NCT02424695 Phase 4 Gabapentin Enacarbil (GEn);Placebo
28 Effect of Atomoxetine on ADHD-Related Insomnia in Children and Adolescents Unknown status NCT00252278 Phase 4 atomoxetine
29 Benefit of One Month Zopiclone Intake on Adaptative Servoventilation Compliance Unknown status NCT02820441 Phase 4 Zopiclone;Placebo
30 CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients. Unknown status NCT01771406 Phase 4 Nebivolol
31 Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic Unknown status NCT02699125 Phase 4 Guanfacine;Hydrochlorothiazide
32 Auto-PAP for Pulmonary Hypertension Treatment in Decompensated HF Patients With Sleep Apnea. Unknown status NCT02963597 Phase 4
33 Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving CPAP Compliance in Low Cardiovascular Risk Sleep Apnea Patients : OPTISAS 1 Study Unknown status NCT01796769 Phase 4
34 PROMAD: Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea Unknown status NCT01532050 Phase 4
35 Blood Pressure Reduction Induced by CPAP in Sleep Apnea Patients at High Cardiovascular Risk : OPTISAS 2 Study Unknown status NCT01505959 Phase 4
36 Comparison of the Pentax AWS® With the Macintosh Laryngoscopic Intubation in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01428570 Phase 4
37 Brain Mechanisms and Targeting Insomnia in Major Depression Unknown status NCT00628914 Phase 4 escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
38 Cost-utility Study of Continuous Positive Airway Pressure Treatment in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01590420 Phase 4
39 Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients Unknown status NCT01524510 Phase 4
40 Study on Magnetic Field Therapy to Improve Quality of Sleep and Reduction of Chronic Spine Pain Unknown status NCT00445133 Phase 4
41 Donepezil Treatment for Sleep Apnea Patients Unknown status NCT00912457 Phase 4 donepezil;placebo
42 Sleep Disordered Breathing in Transient Ischemic Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy Unknown status NCT01097967 Phase 4
43 Inflammatory Response to Anti Inflammatory Therapy in Children With Sleep Disordered Breathing Unknown status NCT00299910 Phase 4 Montelukast
44 Continuous Positive Airway Pressure in Sleep Apnea Syndrome: Effects on Metabolic Syndrome and Cardiac Damage Unknown status NCT00517777 Phase 4
45 Effects of Zolpidem CR® in Sleep and Heart Recovery in Cardiac Intensive Care Unit Patients Unknown status NCT01920334 Phase 4 Zolpidem CR 12.5mg;Placebo
46 Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression Unknown status NCT00291239 Phase 4
47 Sleep Disorders and Gastroesophageal Reflux Disease (GERD) Completed NCT00287391 Phase 4 Rabeprazole
48 Atripla to Stribild Switch Study to Evaluate Sleep Disturbances Completed NCT02477527 Phase 4 Stribild
49 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed NCT01234675 Phase 4 Milnacipran;Milnacipran
50 Effects of Rasagiline on Sleep Disturbances in Parkinson's Disease Completed NCT01442610 Phase 4 Rasagiline;Placebo

Search NIH Clinical Center for Sleep Disorder

Inferred drug relations via UMLS 74 / NDF-RT 52 :
Sources

Genetic Tests for Sleep Disorder

About this section
Sources

Anatomical Context for Sleep Disorder

About this section

MalaCards organs/tissues related to Sleep Disorder:

42
Heart, Brain, Testes, Kidney, Liver, Endothelial, Prostate
Sources

Publications for Sleep Disorder

About this section

Articles related to Sleep Disorder:

(show top 50) (show all 288)
# Title Authors Year
1
Relationship between serum IL-1β and insomnia and liver depression in patients with perimenopausal non-organic sleep disorder. ( 30651860 )
2019
2
The Relationship Between Severity of Epilepsy and Sleep Disorder in Epileptic Children. ( 31037081 )
2019
3
Trauma-Associated Sleep Disorder: A Posttraumatic Stress/REM Sleep Behavior Disorder Mash-Up? ( 30736880 )
2019
4
N-WRETS: Near-Lossless Wireless Real-time Efficient Electroencephalogram Transmission Solution to Support Sleep Disorder Monitoring Platforms. ( 29877756 )
2019
5
Analysis of patients' sleep disorder after total knee arthroplasty-A retrospective study. ( 30146382 )
2019
6
Self-reported Sleep Disorder and Ambulatory Blood Pressure Phenotypes in Patients with or without Chronic Kidney Disease: Findings from Ibadan CRECKID Study. ( 30924118 )
2019
7
Amyloid Î² and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A(1) receptor. ( 30365112 )
2019
8
Pediatric sleep disorder medicine training in Canada: past, present and future. ( 30458976 )
2019
9
Video-Polysomnographic Characterization of Sleep Movements in Children with Restless Sleep Disorder. ( 30602036 )
2019
10
Non-Apnea Sleep Disorder associates with increased risk of incident heart failure-A nationwide population-based cohort study. ( 30650103 )
2019
11
Neurological profiles beyond the sleep disorder in patients with anti-IgLON5 disease. ( 30694925 )
2019
12
Association between sarcopenia and sleep disorder in older patients with diabetes. ( 30773802 )
2019
13
Delayed Sleep Phase Syndrome: A common sleep disorder in adolescents, with important quality of life repercussions. ( 30876698 )
2019
14
Sleep disorder-related headaches. ( 30906963 )
2019
15
Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models. ( 30951822 )
2019
16
The prevalence of restless sleep disorder among a clinical sample of children and adolescents referred to a sleep centre. ( 31087450 )
2019
17
Thermo-parasomnia. Prediction of a possible sleep disorder or entity. ( 31105898 )
2019
18
The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. ( 29908682 )
2018
19
Anti-Ma1- and Anti-Ma2-Associated Encephalitis Manifesting With Rapid Eye Movement Sleep Disorder and Narcolepsy With Cataplexy: A Case Report. ( 28117047 )
2018
20
Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice. ( 29288667 )
2018
21
Non-Apnea Sleep Disorder Increases the Risk of Subsequent Female Infertility-A Nationwide Population-Based Cohort Study. ( 29136234 )
2018
22
Clinical impact of physical exercise on sleep disorder as assessed by actigram in patients with chronic pancreatitis: a study protocol for a randomised controlled trial. ( 29527314 )
2018
23
Association between sleep disorder and panic disorder in South Korea: Nationwide nested case-control study of data from 2004 to 2013. ( 29223044 )
2018
24
Cost-effectiveness of cognitive-behavioural therapy for sleep disorder added to usual care in patients with schizophrenia: the BEST study. ( 29971156 )
2018
25
Trauma associated sleep disorder: A parasomnia induced by trauma. ( 28363448 )
2018
26
Spa therapy (balneotherapy) relieves mental stress, sleep disorder, and general health problems in sub-healthy people. ( 28936572 )
2018
27
Shift work and sleep disorder comorbidity tend to go hand in hand. ( 29157012 )
2018
28
Sleep disorder and altered locomotor activity as biomarkers of the Parkinson's disease cholinopathy in rat. ( 29170000 )
2018
29
Sleep disorder diagnoses and clinical outcomes among hospitalized breast cancer patients: a nationwide inpatient sample study. ( 29264658 )
2018
30
Assessing the sleeping habits of patients in a sleep disorder centre: a review of sleep diary accuracy. ( 29445542 )
2018
31
Sleep disorder prevalence in at-risk adolescents and potential effects of nightmare triad syndrome. ( 29453926 )
2018
32
Zaleplon loaded bi-layered chronopatch: A novel buccal chronodelivery approach to overcome circadian rhythm related sleep disorder. ( 29526622 )
2018
33
Sleep disorder risk factors among student athletes. ( 29530373 )
2018
34
Sleep disorders in children with brain tumors: a pilot study based on a sleep disorder questionnaire. ( 29700571 )
2018
35
Restless sleep disorder in children: a pilot study on a tentative new diagnostic category. ( 29771368 )
2018
36
The Sleep Disorder in Anti-lgLON5 Disease. ( 29796717 )
2018
37
Association between long-term exposure to air pollution and sleep disorder in Chinese children: the Seven Northeastern Cities study. ( 29939357 )
2018
38
Association between long-term exposure to air pollution and sleep disorder in Chinese children: the Seven Northeastern Cities study. ( 30053274 )
2018
39
Prevalence and correlates of sleep disorder symptoms in psychiatric disorders. ( 30072039 )
2018
40
Cognitive behavioral therapy for insomnia combined with eszopiclone for the treatment of sleep disorder patients transferred out of the intensive care unit: A single-centred retrospective observational study. ( 30213004 )
2018
41
Magnesium Intake and Sleep Disorder Symptoms: Findings from the Jiangsu Nutrition Study of Chinese Adults at Five-Year Follow-Up. ( 30248967 )
2018
42
Melatonin: A New-Generation Therapy for Reducing Chronic Pain and Improving Sleep Disorder-Related Pain. ( 30306528 )
2018
43
An analysis of whether sleep disorder will result in postpartum depression. ( 29861873 )
2018
44
Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis. ( 29652034 )
2018
45
Interactive Sleep Stage Labelling Tool For Diagnosing Sleep Disorder Using Deep Learning. ( 30440368 )
2018
46
The Association between Migraine and Types of Sleep Disorder. ( 30486273 )
2018
47
Impact of an Individually Tailored Light Mask on Sleep Parameters in Older Adults With Advanced Phase Sleep Disorder. ( 30588849 )
2018
48
Sleep disorder, Mediterranean Diet and learning performance among nursing students: inSOMNIA, a cross-sectional study. ( 30614496 )
2018
49
Trauma-Associated Sleep Disturbances: a Distinct Sleep Disorder? ( 30656131 )
2018
50
REM sleep disorder following general anesthesia in rats. ( 27771371 )
2017
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Variations for Sleep Disorder

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Expression for Sleep Disorder

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Search GEO for disease gene expression data for Sleep Disorder.
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Pathways for Sleep Disorder

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Pathways related to Sleep Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
2
Circadian rhythm 38
Show member pathways
 10.97 CRY1 PER2 PER3
3
Melatonin metabolism and effects 1
10.7 CRY1 PER2 PER3
Sources

GO Terms for Sleep Disorder

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Cellular components related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axolemma GO:0030673 8.62 ADORA1 MAPT

Biological processes related to Sleep Disorder according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 rhythmic process GO:0048511 9.69 CRY1 PER2 PER3
2 positive regulation of cold-induced thermogenesis GO:0120162 9.65 HCRT LEP PER2
3 eating behavior GO:0042755 9.54 HCRT LEP
4 temperature homeostasis GO:0001659 9.52 ADORA1 HCRT
5 circadian regulation of gene expression GO:0032922 9.5 CRY1 PER2 PER3
6 positive regulation of superoxide anion generation GO:0032930 9.49 CRP MAPT
7 central nervous system neuron development GO:0021954 9.46 LEP MAPT
8 neuropeptide signaling pathway GO:0007218 9.46 HCRT HCRTR1 HCRTR2 NPS
9 negative regulation of blood vessel diameter GO:0097756 9.43 ADORA1 CRP
10 feeding behavior GO:0007631 9.43 HCRT HCRTR1 HCRTR2
11 negative regulation of circadian rhythm GO:0042754 9.4 CRY1 PER2
12 negative regulation of lipid storage GO:0010888 9.37 CRP LEP
13 entrainment of circadian clock by photoperiod GO:0043153 9.13 CRY1 PER2 PER3
14 circadian rhythm GO:0007623 8.92 CRY1 LEP PER2 PER3

Molecular functions related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription corepressor binding GO:0001222 8.96 PER2 PER3
2 orexin receptor activity GO:0016499 8.62 HCRTR1 HCRTR2
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Sources for Sleep Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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