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MCID: SLP005
MIFTS: 57

Sleep Disorder

Categories: Mental diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Sleep Disorder

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MalaCards integrated aliases for Sleep Disorder:

Name: Sleep Disorder 12 15
Non-Organic Sleep Disorder 12 73
Sleep Disorders 43 73

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:535
ICD9CM 35 307.4
ICD10 33 F51 G47 G47.9
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Summaries for Sleep Disorder

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MedlinePlus : 43 Is it hard for you to fall asleep or stay asleep through the night? Do you wake up feeling tired or feel very sleepy during the day, even if you have had enough sleep? You might have a sleep disorder. The most common kinds are Insomnia - a hard time falling or staying asleep Sleep apnea - breathing interruptions during sleep Restless legs syndrome - a tingling or prickly sensation in the legs Narcolepsy - daytime "sleep attacks" Nightmares, night terrors, sleepwalking, sleep talking, head banging, wetting the bed and grinding your teeth are kinds of sleep problems called parasomnias. There are treatments for most sleep disorders. Sometimes just having good sleep habits can help.

MalaCards based summary : Sleep Disorder, also known as non-organic sleep disorder, is related to advanced sleep phase syndrome and sleep apnea, and has symptoms including seizures, tremor and fever. An important gene associated with Sleep Disorder is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are Circadian rythm related genes and Circadian rhythm. The drugs Alginic acid and Esomeprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and heart, and related phenotypes are behavior/neurological and muscle

Disease Ontology : 12 A disease of mental health that involves disruption of sleep patterns.

Wikipedia : 76 A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal. ... more...

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Related Diseases for Sleep Disorder

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Diseases related to Sleep Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 327)
# Related Disease Score Top Affiliating Genes
1 advanced sleep phase syndrome 32.6 HCRT PER2 PER3
2 sleep apnea 32.5 CRP HCRT LEP
3 delayed sleep phase disorder 32.2 CRY1 PER2 PER3
4 narcolepsy 1 32.2 HCRT MOG
5 narcolepsy 31.9 HCRT HCRTR1 HCRTR2 LEP MOG
6 periodic limb movement disorder 31.7 CTNNBL1 FXYD1
7 cluster headache 29.9 HCRTR2 PRL
8 rohhad 29.6 HCRT HCRTR1 HCRTR2
9 morbid obesity 29.5 CRP HCRT LEP
10 apnea, obstructive sleep 29.2 ARIH1 CRP CTNNBL1 FXYD1 HCRT LEP
11 non 24 hour sleep wake disorder 11.6
12 mental retardation, autosomal recessive 37 11.5
13 idiopathic hypersomnia 11.5
14 recurrent hypersomnia 11.3
15 rem sleep behavior disorder 11.2
16 machado-joseph disease 11.2
17 kleine-levin hibernation syndrome 11.1
18 bruxism 11.1
19 hypersomnia 11.1
20 migraine with or without aura 1 11.1
21 creutzfeldt-jakob disease 11.1
22 advanced sleep phase syndrome, familial, 1 11.1
23 short sleeper 10.9
24 neurodevelopmental disorder with severe motor impairment and absent language 10.9
25 progeroid short stature with pigmented nevi 10.7
26 brunner syndrome 10.7
27 fatal familial insomnia 10.7
28 chromosome 1q21.1 deletion syndrome, 1.35-mb 10.7
29 narcolepsy 7 10.7
30 lyme disease - neurological complications 10.7
31 depression 10.2
32 neuromuscular disease 10.2
33 central hypoventilation syndrome, congenital 10.2
34 epilepsy 10.2
35 restless legs syndrome 10.1
36 prader-willi syndrome 10.1
37 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.1 CRP LEP
38 melancholia 10.1 CRP PRL
39 diabetes mellitus 10.1
40 rhinitis 10.1
41 anovulation 10.1 CRP LEP PRL
42 multiple system atrophy 1 10.1
43 chiari malformation 10.1
44 anorexia nervosa 10.1 HCRT LEP PRL
45 acquired metabolic disease 10.1 CRP LEP PRL
46 achondroplasia 10.1
47 down syndrome 10.1
48 allergic rhinitis 10.1
49 anxiety 10.1
50 muscular dystrophy 10.0

Graphical network of the top 20 diseases related to Sleep Disorder:



Diseases related to Sleep Disorder
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Symptoms & Phenotypes for Sleep Disorder

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UMLS symptoms related to Sleep Disorder:


seizures, tremor, fever, dyspnea, edema, back pain, cachexia, vertigo, pain, headache, syncope, cyanosis, chronic pain, sciatica, sleep disturbances, snoring, nervousness, icterus, signs and symptoms, signs and symptoms, digestive, hot flushes, vertigo/dizziness, sleeplessness, psychiatric symptom, sluggishness, nightmares, hallucinations, hypnagogic

MGI Mouse Phenotypes related to Sleep Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 ANK3 CRY1 HAPLN1 HCRT HCRTR1 HCRTR2
2 muscle MP:0005369 9.56 CRY1 FXYD1 HCRT HCRTR2 LEP MOG
3 nervous system MP:0003631 9.36 ANK3 CRY1 HCRT HCRTR1 HCRTR2 LEP
Sources

Drugs & Therapeutics for Sleep Disorder

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Drugs for Sleep Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 928)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alginic acid Approved, Investigational Phase 4,Not Applicable 9005-32-7
2
Esomeprazole Approved, Investigational Phase 4,Phase 3 161796-78-7, 119141-88-7 4594 9579578
3
Apomorphine Approved, Investigational Phase 4 41372-20-7, 58-00-4 6005
4
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-61-6, 62-31-7 681
5
Clonidine Approved Phase 4,Phase 2,Not Applicable 4205-90-7 2803
6
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 56-12-2 119
7
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 60142-96-3 3446
8
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 64-17-5 702
9
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 57-27-2 5288826
10
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
11 Piracetam Approved, Investigational Phase 4,Phase 3,Phase 2 7491-74-9
12
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
13
Clonazepam Approved, Illicit Phase 4,Phase 2,Not Applicable 1622-61-3 2802
14
Acetylcholine Approved Phase 4,Phase 2,Phase 1 51-84-3 187
15
Zolpidem Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 82626-48-0 5732
16
Ropinirole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 91374-21-9, 91374-20-8 497540 5095
17
Pramipexole Approved, Investigational Phase 4,Phase 3,Phase 2 104632-26-0 119570 59868
18
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 148553-50-8 5486971
19
Imipramine Approved Phase 4,Phase 3 50-49-7 3696
20
Dexlansoprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 103577-45-3, 138530-94-6 9578005
21
Lansoprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 103577-45-3 3883
22
Zopiclone Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 43200-80-2 5735
23
Suvorexant Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1030377-33-3
24
Promethazine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 60-87-7 4927
25
Diphenhydramine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 147-24-0, 58-73-1 3100
26
Nebivolol Approved, Investigational Phase 4 99200-09-6, 152520-56-4, 118457-14-0 71301
27 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
29
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
30
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
31
Citalopram Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 59729-33-8 2771
32
Eszopiclone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 138729-47-2 969472
33
Donepezil Approved Phase 4,Phase 3,Phase 2,Phase 1 120014-06-4 3152
34
Montelukast Approved Phase 4,Phase 3,Phase 2,Not Applicable 158966-92-8 5281040
35
Efavirenz Approved, Investigational Phase 4,Phase 3,Not Applicable 154598-52-4 64139
36
Acetazolamide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-66-5 1986
37
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 51-45-6, 75614-87-8 774
38
Armodafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 112111-43-0
39
Modafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 68693-11-8 4236
40
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 6740-88-1 3821
41
Allopurinol Approved Phase 4,Phase 2,Not Applicable 315-30-0 2094
42
Lithium carbonate Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 554-13-2
43
Valproic Acid Approved, Investigational Phase 4,Phase 1,Phase 2 99-66-1 3121
44
Sertraline Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 79617-96-2 68617
45
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 61869-08-7 43815
46
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 52485-79-7 40400 644073
47
Methylphenidate Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 113-45-1 4158
48
Estazolam Approved, Illicit Phase 4,Phase 3 29975-16-4 3261
49
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 113775-47-6 68602 5311068
50
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 54910-89-3 3386

Interventional clinical trials:

(show top 50) (show all 4514)
# Name Status NCT ID Phase Drugs
1 Sleep Disturbances in Hospitalized Children Unknown status NCT00749814 Phase 4
2 Esomeprazole Plus Alginate vs. Esomeprazole Alone for Treatment of Nighttime Reflux Symptom and Sleep Disturbances Unknown status NCT02277886 Phase 4 sodium alginate;esomeprazole
3 Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease Unknown status NCT02768077 Phase 4 Melatonin(Circadin®);Placebo
4 Effect of Continuous Apomorphine During the Night on Sleep Disorders in Insomniac Patients With Parkinson's Disease Unknown status NCT02940912 Phase 4 Apomorphine;Placebo
5 Effect of Rozerem on Sleep Among People With Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
6 Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD Unknown status NCT00152750 Phase 4 APO-clonidine
7 Somnodent vs Herbst in Mild and Moderate OSA Patients Unknown status NCT02724865 Phase 4
8 Treatment for Alcohol Dependence With Gabapentin Unknown status NCT02771925 Phase 4 Gabapentin 2g/day divided in two doses for 24 weeks;Placebo 2g/day divided in two doses for 24 weeks
9 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
10 Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
11 Are Patients Suffering From DSPS Show Compromising in Everyday Functions and Abilities Before Handling the Disorder? Unknown status NCT02962037 Phase 4
12 Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status Unknown status NCT02135055 Phase 4 Midazolam;Morphine
13 Levetiracetam Treatment of Children With Subclinical Sleep-Activated Epileptiform Activity (SSEA) Unknown status NCT00393614 Phase 4 levetiracetam
14 Neurochemical, Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder Unknown status NCT02346682 Phase 4 venlafaxine
15 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
16 Bioboosti Device for Insomnia Treatment Unknown status NCT02924116 Phase 4
17 Efficacy and Safety of 5 mg Sublingual Zolpidem vs 10mg Oral Zolpidem in the Induction and Maintenance of Sleep in Patients With Primary Insomnia Unknown status NCT01896336 Phase 4 Zolpidem Hemitartrate
18 Effects of Ramelteon (8mg) Alone and in Combination With Multi-Component Behavioral Therapy on Sleep and Circadian Phase in Patients With Chronic Insomnia Unknown status NCT01180855 Phase 4 Placebo;Rozerem 8mg
19 Study to Observe the Effect of Mirapex ER® Once-daily (QD) Versus Twice-daily (BID) Unknown status NCT01515774 Phase 4 Mirapex ER
20 Clinical Trial to Evaluate the Efficacy of FITOGYN Versus Placebo on the Vasomotor Symptomatology Associated With Menopause Unknown status NCT01116310 Phase 4 Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L);Placebo
21 Imipramine and Pregabalin Combination in Painful Polyneuropathy Unknown status NCT01047488 Phase 4 Imipramine;Pregabalin;Imipramine, pregabalin;Placebo
22 Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy Unknown status NCT01328652 Phase 4 dexlansoprazole
23 Effects of Gabapentin Enacarbil on Arousals, Heart Rate, Blood Pressure and PLMs in Restless Legs Syndrome Unknown status NCT02424695 Phase 4 Gabapentin Enacarbil (GEn);Placebo
24 Effect of Atomoxetine on ADHD-Related Insomnia in Children and Adolescents Unknown status NCT00252278 Phase 4 atomoxetine
25 Benefit of One Month Zopiclone Intake on Adaptative Servoventilation Compliance Unknown status NCT02820441 Phase 4 Zopiclone;Placebo
26 Cardiovascular Impact, Quality e Quantity of Sleep in Bed Partners of Patients With Obstructive Sleep Apnea Unknown status NCT03011294 Phase 4
27 A Six Week, Randomized, Double-Blind Placebo-Controlled, Suvorexant Augmentation Study of Antidepressant Treatment of Major Depressive Disorder With Residual Insomnia Unknown status NCT02669030 Phase 4 suvorexant;Placebo
28 CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients. Unknown status NCT01771406 Phase 4 Nebivolol
29 Auto-PAP for Pulmonary Hypertension Treatment in Decompensated HF Patients With Sleep Apnea. Unknown status NCT02963597 Phase 4
30 Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic Unknown status NCT02699125 Phase 4 Guanfacine;Hydrochlorothiazide
31 Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving CPAP Compliance in Low Cardiovascular Risk Sleep Apnea Patients : OPTISAS 1 Study Unknown status NCT01796769 Phase 4
32 Impact of Obstructive Sleep Apnea Treatment in Patients With Metabolic Syndrome Unknown status NCT02295202 Phase 4
33 PROMAD: Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea Unknown status NCT01532050 Phase 4
34 Blood Pressure Reduction Induced by CPAP in Sleep Apnea Patients at High Cardiovascular Risk : OPTISAS 2 Study Unknown status NCT01505959 Phase 4
35 Comparison of the Pentax AWS® With the Macintosh Laryngoscopic Intubation in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01428570 Phase 4
36 Brain Mechanisms and Targeting Insomnia in Major Depression Unknown status NCT00628914 Phase 4 escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
37 Cost-utility Study of Continuous Positive Airway Pressure Treatment in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01590420 Phase 4
38 Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients Unknown status NCT01524510 Phase 4
39 Donepezil Treatment for Sleep Apnea Patients Unknown status NCT00912457 Phase 4 donepezil;placebo
40 Sleep Disordered Breathing in Transient Ischemic Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy Unknown status NCT01097967 Phase 4
41 Study on Magnetic Field Therapy to Improve Quality of Sleep and Reduction of Chronic Spine Pain Unknown status NCT00445133 Phase 4
42 Inflammatory Response to Anti Inflammatory Therapy in Children With Sleep Disordered Breathing Unknown status NCT00299910 Phase 4 Montelukast
43 Continuous Positive Airway Pressure in Sleep Apnea Syndrome: Effects on Metabolic Syndrome and Cardiac Damage Unknown status NCT00517777 Phase 4
44 Effects of Zolpidem CR® in Sleep and Heart Recovery in Cardiac Intensive Care Unit Patients Unknown status NCT01920334 Phase 4 Zolpidem CR 12.5mg;Placebo
45 Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression Unknown status NCT00291239 Phase 4
46 Sleep Disorders and Gastroesophageal Reflux Disease (GERD) Completed NCT00287391 Phase 4 Rabeprazole
47 Atripla to Stribild Switch Study to Evaluate Sleep Disturbances Completed NCT02477527 Phase 4 Stribild
48 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed NCT01234675 Phase 4 Milnacipran;Milnacipran
49 Effects of Rasagiline on Sleep Disturbances in Parkinson's Disease Completed NCT01442610 Phase 4 Rasagiline;Placebo
50 A Phase IV Trial With Pramipexole to Investigate the Effects on RLS Symptoms and Sleep Disturbance in Patients With RLS Completed NCT00349531 Phase 4 Pramipexole

Search NIH Clinical Center for Sleep Disorder

Inferred drug relations via UMLS 73 / NDF-RT 51 :
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Genetic Tests for Sleep Disorder

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Anatomical Context for Sleep Disorder

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MalaCards organs/tissues related to Sleep Disorder:

41
Testes, Brain, Heart, Skin, Lung, Kidney, Liver
Sources

Publications for Sleep Disorder

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Articles related to Sleep Disorder:

(show top 50) (show all 272)
# Title Authors Year
1
Amyloid Î² and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A(1) receptor. ( 30365112 )
2019
2
Zaleplon loaded bi-layered chronopatch: A novel buccal chronodelivery approach to overcome circadian rhythm related sleep disorder. ( 29526622 )
2018
3
Sleep disorder prevalence in at-risk adolescents and potential effects of nightmare triad syndrome. ( 29453926 )
2018
4
N-WRETS: Near-Lossless Wireless Real-time Efficient Electroencephalogram Transmission Solution to Support Sleep Disorder Monitoring Platforms. ( 29877756 )
2018
5
Sleep disorder risk factors among student athletes. ( 29530373 )
2018
6
Shift work and sleep disorder comorbidity tend to go hand in hand. ( 29157012 )
2018
7
Association between Long-term Exposure to Air Pollution and Sleep Disorder in Chinese Children: The Seven Northeastern Cities (SNEC) Study. ( 29939357 )
2018
8
An analysis of whether sleep disorder will result in postpartum depression. ( 29861873 )
2018
9
Clinical impact of physical exercise on sleep disorder as assessed by actigram in patients with chronic pancreatitis: a study protocol for a randomised controlled trial. ( 29527314 )
2018
10
Sleep disorders in children with brain tumors: a pilot study based on a sleep disorder questionnaire. ( 29700571 )
2018
11
The Sleep Disorder in Anti-lgLON5 Disease. ( 29796717 )
2018
12
Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice. ( 29288667 )
2018
13
Assessing the sleeping habits of patients in a sleep disorder centre: a review of sleep diary accuracy. ( 29445542 )
2018
14
Non-Apnea Sleep Disorder Increases the Risk of Subsequent Female Infertility-A Nationwide Population-Based Cohort Study. ( 29136234 )
2018
15
The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. ( 29908682 )
2018
16
Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis. ( 29652034 )
2018
17
Sleep disorder and altered locomotor activity as biomarkers of the Parkinson's disease cholinopathy in rat. ( 29170000 )
2018
18
Cost-effectiveness of cognitive-behavioural therapy for sleep disorder added to usual care in patients with schizophrenia: the BEST study. ( 29971156 )
2018
19
Restless sleep disorder in children: a pilot study on a tentative new diagnostic category. ( 29771368 )
2018
20
Association between long-term exposure to air pollution and sleep disorder in Chinese children: the Seven Northeastern Cities study. ( 30053274 )
2018
21
Prevalence and correlates of sleep disorder symptoms in psychiatric disorders. ( 30072039 )
2018
22
Analysis of patients' sleep disorder after total knee arthroplasty-A retrospective study. ( 30146382 )
2018
23
Cognitive behavioral therapy for insomnia combined with eszopiclone for the treatment of sleep disorder patients transferred out of the intensive care unit: A single-centred retrospective observational study. ( 30213004 )
2018
24
Magnesium Intake and Sleep Disorder Symptoms: Findings from the Jiangsu Nutrition Study of Chinese Adults at Five-Year Follow-Up. ( 30248967 )
2018
25
Melatonin: A New-Generation Therapy for Reducing Chronic Pain and Improving Sleep Disorder-Related Pain. ( 30306528 )
2018
26
Interactive Sleep Stage Labelling Tool For Diagnosing Sleep Disorder Using Deep Learning. ( 30440368 )
2018
27
Pediatric sleep disorder medicine training in Canada: past, present and future. ( 30458976 )
2018
28
The Association between Migraine and Types of Sleep Disorder. ( 30486273 )
2018
29
REM sleep disorder following general anesthesia in rats. ( 27771371 )
2017
30
Dante Alighieri: evidence for sleep disorder-related cardiac autonomic dysfunctions. ( 28000594 )
2017
31
Trauma associated sleep disorder: A parasomnia induced by trauma. ( 28363448 )
2017
32
Sleep Disorder as a Triggering Factor for Relapse in Multiple Sclerosis. ( 28359058 )
2017
33
Risk factors of sleep disorder after stroke: a meta-analysis. ( 27686181 )
2017
34
Sleep Disorder Diagnosis During Pregnancy and Risk of Preterm Birth. ( 28796676 )
2017
35
Spa therapy (balneotherapy) relieves mental stress, sleep disorder, and general health problems in sub-healthy people. ( 28936572 )
2017
36
Sleep disorder, an independent risk associated with arterial stiffness in menopause. ( 28507296 )
2017
37
Feasibility of a respiratory nurse specialist-led sleep disorder service in a district general hospital. ( 28675190 )
2017
38
Association between sleep disorder and panic disorder in South Korea: Nationwide nested case-control study of data from 2004 to 2013. ( 29223044 )
2017
39
Incidence of Prosthetic Complications associated with Implant-borne Prosthesis in a Sleep Disorder Center. ( 28874648 )
2017
40
Sleep disorder diagnoses and clinical outcomes among hospitalized breast cancer patients: a nationwide inpatient sample study. ( 29264658 )
2017
41
Frequency of Prosthetic Complications Related to Implant-Borne Prosthesis in a Sleep Disorder Unit. ( 27700231 )
2017
42
A Case of Undiagnosed Sleep Disorder with Hearing Difficulty and Dizziness. ( 27280102 )
2016
43
Text Mining of Journal Articles for Sleep Disorder Terminologies. ( 27203858 )
2016
44
Shift Work and Shift Work Sleep Disorder: Clinical and Organizational Perspectives. ( 28012806 )
2016
45
How to Prepare for an Emergency or Disaster When You Have Lung Disease or a Sleep Disorder. ( 27689713 )
2016
46
Diagnosis of insomnia sleep disorder using short time frequency analysis of PSD approach applied on EEG signal using channel ROC-LOC. ( 28123658 )
2016
47
Sleep Disorder, Gastrointestinal Problems and Behaviour Problems Seen in Autism Spectrum Disorder Children and Yoga as Therapy: A Descriptive Review. ( 28050484 )
2016
48
Parkinson disease. Sleep disorder deficits suggest signature for early Parkinson disease. ( 26635212 )
2016
49
Sleep disorder or simple sleep ontogeny? Tendency for morningness is associated with worse sleep quality in the elderly. ( 27737315 )
2016
50
Relationships between nutritional knowledge, obesity, and sleep disorder severity. ( 26843133 )
2016
Sources

Variations for Sleep Disorder

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Expression for Sleep Disorder

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Search GEO for disease gene expression data for Sleep Disorder.
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Pathways for Sleep Disorder

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Pathways related to Sleep Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
2
Circadian rhythm 37
Show member pathways
 10.97 CRY1 PER2 PER3
3
Melatonin metabolism and effects 1
10.7 CRY1 PER2 PER3
Sources

GO Terms for Sleep Disorder

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Biological processes related to Sleep Disorder according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 rhythmic process GO:0048511 9.69 CRY1 PER2 PER3
2 glucose homeostasis GO:0042593 9.67 CRY1 LEP TFAP2B
3 positive regulation of cold-induced thermogenesis GO:0120162 9.65 HCRT LEP PER2
4 regulation of insulin secretion GO:0050796 9.58 LEP PER2 TFAP2B
5 positive regulation of JAK-STAT cascade GO:0046427 9.54 LEP PRL
6 eating behavior GO:0042755 9.52 HCRT LEP
7 circadian regulation of gene expression GO:0032922 9.5 CRY1 PER2 PER3
8 negative regulation of circadian rhythm GO:0042754 9.46 CRY1 PER2
9 neuropeptide signaling pathway GO:0007218 9.46 HCRT HCRTR1 HCRTR2 NPS
10 negative regulation of lipid storage GO:0010888 9.43 CRP LEP
11 feeding behavior GO:0007631 9.43 HCRT HCRTR1 HCRTR2
12 magnesium ion homeostasis GO:0010960 9.37 ANK3 TFAP2B
13 entrainment of circadian clock by photoperiod GO:0043153 9.13 CRY1 PER2 PER3
14 circadian rhythm GO:0007623 9.02 CRY1 LEP PER2 PER3 PRL

Molecular functions related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription corepressor binding GO:0001222 8.96 PER2 PER3
2 orexin receptor activity GO:0016499 8.62 HCRTR1 HCRTR2
Sources

Sources for Sleep Disorder

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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