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MCID: SLP005
MIFTS: 59

Sleep Disorder

Categories: Mental diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Sleep Disorder

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MalaCards integrated aliases for Sleep Disorder:

Name: Sleep Disorder 12 15
Non-Organic Sleep Disorder 12 73
Sleep Disorders 43 73

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:535
ICD9CM 35 307.4
ICD10 33 F51 G47 G47.9
Sources

Summaries for Sleep Disorder

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MedlinePlus : 43 Is it hard for you to fall asleep or stay asleep through the night? Do you wake up feeling tired or feel very sleepy during the day, even if you have had enough sleep? You might have a sleep disorder. The most common kinds are Insomnia - a hard time falling or staying asleep Sleep apnea - breathing interruptions during sleep Restless legs syndrome - a tingling or prickly sensation in the legs Narcolepsy - daytime "sleep attacks" Nightmares, night terrors, sleepwalking, sleep talking, head banging, wetting the bed and grinding your teeth are kinds of sleep problems called parasomnias. There are treatments for most sleep disorders. Sometimes just having good sleep habits can help.

MalaCards based summary : Sleep Disorder, also known as non-organic sleep disorder, is related to advanced sleep phase syndrome and sleep apnea, and has symptoms including back pain, cachexia and cyanosis. An important gene associated with Sleep Disorder is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are Circadian rythm related genes and Circadian rhythm. The drugs Lansoprazole and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related phenotypes are behavior/neurological and muscle

Disease Ontology : 12 A disease of mental health that involves disruption of sleep patterns.

Wikipedia : 76 A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal. Some... more...

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Related Diseases for Sleep Disorder

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Diseases related to Sleep Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
# Related Disease Score Top Affiliating Genes
1 advanced sleep phase syndrome 33.0 HCRT PER2 PER3
2 sleep apnea 32.3 CRP HCRT LEP
3 delayed sleep phase disorder 32.2 CRY1 PER2 PER3
4 periodic limb movement disorder 31.1 CTNNBL1 FXYD1
5 cluster headache 29.9 HCRT HCRTR2
6 narcolepsy 29.8 CTNNBL1 HAPLN1 HCRT HCRTR1 HCRTR2 LEP
7 rohhad 29.8 HCRT HCRTR1 HCRTR2
8 morbid obesity 29.7 CRP HCRT LEP
9 apnea, obstructive sleep 28.1 ARIH1 CRP CTNNBL1 FXYD1 HCRT LEP
10 non 24 hour sleep wake disorder 11.7
11 mental retardation, autosomal recessive 37 11.4
12 idiopathic hypersomnia 11.3
13 rem sleep behavior disorder 11.1
14 machado-joseph disease 11.1
15 recurrent hypersomnia 11.0
16 bruxism 11.0
17 hypersomnia 11.0
18 angelman syndrome 10.9
19 creutzfeldt-jakob disease 10.9
20 advanced sleep phase syndrome, familial, 1 10.9
21 narcolepsy 1 10.7
22 short sleeper 10.7
23 migraine with or without aura 1 10.6
24 progeroid short stature with pigmented nevi 10.6
25 brunner syndrome 10.6
26 fatal familial insomnia 10.6
27 chromosome 1q21.1 deletion syndrome, 1.35-mb 10.6
28 narcolepsy 7 10.6
29 neurodevelopmental disorder with severe motor impairment and absent language 10.6
30 lyme disease - neurological complications 10.6
31 hallucinogen dependence 10.5 HCRTR1 HCRTR2
32 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.4 CRP LEP
33 melancholia 10.4 CRP PRL
34 acute disseminated encephalomyelitis 10.3 HCRT MOG
35 anorexia nervosa 10.2 HCRT LEP PRL
36 acquired metabolic disease 10.2 CRP LEP PRL
37 depression 10.1
38 kleine-levin hibernation syndrome 10.0
39 central hypoventilation syndrome, congenital 10.0
40 epilepsy 10.0
41 neuromuscular disease 10.0
42 restless legs syndrome 10.0
43 achondroplasia 10.0
44 prader-willi syndrome 10.0
45 multiple system atrophy 1 9.9
46 diabetes mellitus 9.9
47 inherited metabolic disorder 9.9 CRP LEP MMD
48 attention deficit-hyperactivity disorder 9.9
49 anxiety 9.9
50 systolic heart failure 9.9

Graphical network of the top 20 diseases related to Sleep Disorder:



Diseases related to Sleep Disorder
Sources

Symptoms & Phenotypes for Sleep Disorder

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UMLS symptoms related to Sleep Disorder:


back pain, cachexia, cyanosis, dyspnea, edema, fever, headache, icterus, nervousness, nightmares, pain, sciatica, seizures, signs and symptoms, signs and symptoms, digestive, sleep disturbances, snoring, syncope, tremor, vertigo, chronic pain, psychiatric symptom, hallucinations, hypnagogic, vertigo/dizziness, hot flushes, sleeplessness, sluggishness

MGI Mouse Phenotypes related to Sleep Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 PER2 PER3 PRL TFAP2B ANK3 CRY1
2 muscle MP:0005369 9.56 CRY1 FXYD1 HCRT HCRTR2 LEP MOG
3 nervous system MP:0003631 9.36 ANK3 CRY1 HCRT HCRTR1 HCRTR2 LEP
Sources

Drugs & Therapeutics for Sleep Disorder

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Drugs for Sleep Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 886)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lansoprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 103577-45-3 3883
2
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 137-58-6 3676
3
Mirtazapine Approved Phase 4,Phase 3,Phase 2,Phase 1 85650-52-8, 61337-67-5 4205
4
Sertraline Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 79617-96-2 68617
5
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2216-51-5 16666
6
Acetazolamide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-66-5 1986
7
Amlodipine Approved Phase 4,Phase 2,Phase 3 88150-42-9 2162
8
Varenicline Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 249296-44-4 5310966
9
Trazodone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 19794-93-5 5533
10
Imipramine Approved Phase 4,Phase 3 50-49-7 3696
11
Mianserin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 24219-97-4 4184
12
Bupivacaine Approved, Investigational Phase 4,Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
13
Clonidine Approved Phase 4,Phase 2,Not Applicable 4205-90-7 2803
14
Esomeprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
15
Allopurinol Approved Phase 4,Phase 2,Not Applicable 315-30-0 2094
16
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
17
Valsartan Approved, Investigational Phase 4,Not Applicable 137862-53-4 60846
18
Acetylcholine Approved Phase 4,Phase 2,Phase 1 51-84-3 187
19
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
20
Budesonide Approved Phase 4,Phase 3,Phase 2 51333-22-3 63006 5281004
21
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 52485-79-7 40400 644073
22
Modafinil Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 68693-11-8 4236
23
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
24
Guanfacine Approved, Investigational Phase 4,Phase 3 29110-47-2 3519
25 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 979-32-8
26
Carbidopa Approved Phase 4,Phase 3,Phase 2,Not Applicable 28860-95-9 34359 38101
27
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 6740-88-1 3821
28
Eszopiclone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 138729-47-2 969472
29
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 60142-96-3 3446
30
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 22916-47-8 4189
31
Amitriptyline Approved Phase 4,Phase 2,Phase 3,Not Applicable 50-48-6 2160
32
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 57-27-2 5288826
33 Piracetam Approved, Investigational Phase 4,Phase 3,Phase 2 7491-74-9
34
Ropinirole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 91374-20-8, 91374-21-9 5095 497540
35
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
36
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 148553-50-8 5486971
37
Pramipexole Approved, Investigational Phase 4,Phase 3,Phase 2 104632-26-0 59868 119570
38
Nitric Oxide Approved Phase 4 10102-43-9 145068 160954
39
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
40
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 113775-47-6 68602 5311068
41
Valproic Acid Approved, Investigational Phase 4,Phase 1,Phase 2 99-66-1 3121
42
Montelukast Approved Phase 4,Phase 3,Phase 2,Not Applicable 158966-92-8 5281040
43
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-24-8 5755
44
Citalopram Approved Phase 4,Phase 3,Phase 2,Not Applicable 59729-33-8 2771
45
Ibuprofen Approved Phase 4,Phase 3,Not Applicable 15687-27-1 3672
46
Efavirenz Approved, Investigational Phase 4,Phase 3,Not Applicable 154598-52-4 64139
47
Diphenhydramine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-24-0, 58-73-1 3100
48
Levodopa Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-92-7 6047
49
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 2078-54-8 4943
50
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 75614-87-8, 51-45-6 774

Interventional clinical trials:

(show top 50) (show all 4173)
# Name Status NCT ID Phase Drugs
1 Sleep Disturbances in Hospitalized Children Unknown status NCT00749814 Phase 4
2 Esomeprazole Plus Alginate vs. Esomeprazole Alone for Treatment of Nighttime Reflux Symptom and Sleep Disturbances Unknown status NCT02277886 Phase 4 sodium alginate;esomeprazole
3 Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease Unknown status NCT02768077 Phase 4 Melatonin(Circadin®);Placebo
4 Effect of Rozerem on Sleep Among People With Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
5 Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD Unknown status NCT00152750 Phase 4 APO-clonidine
6 Somnodent vs Herbst in Mild and Moderate OSA Patients Unknown status NCT02724865 Phase 4
7 Treatment for Alcohol Dependence With Gabapentin Unknown status NCT02771925 Phase 4 Gabapentin 2g/day divided in two doses for 24 weeks;Placebo 2g/day divided in two doses for 24 weeks
8 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
9 Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
10 Herbal Alternatives for Menopause Symptoms (HALT Study) Unknown status NCT00169299 Phase 4 Black cohosh;Multibotanical preparation;Multibotanical preparation + dietary soy counseling;Conjugated equine estrogen +/- medroxyprogesterone acetate
11 Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status Unknown status NCT02135055 Phase 4 Midazolam;Morphine
12 Levetiracetam Treatment of Children With Subclinical Sleep-Activated Epileptiform Activity (SSEA) Unknown status NCT00393614 Phase 4 levetiracetam
13 Neurochemical, Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder Unknown status NCT02346682 Phase 4 venlafaxine
14 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
15 Efficacy and Safety of 5 mg Sublingual Zolpidem vs 10mg Oral Zolpidem in the Induction and Maintenance of Sleep in Patients With Primary Insomnia Unknown status NCT01896336 Phase 4 Zolpidem Hemitartrate
16 Effects of Ramelteon (8mg) Alone and in Combination With Multi-Component Behavioral Therapy on Sleep and Circadian Phase in Patients With Chronic Insomnia Unknown status NCT01180855 Phase 4 Placebo;Rozerem 8mg
17 Study to Observe the Effect of Mirapex ER® Once-daily (QD) Versus Twice-daily (BID) Unknown status NCT01515774 Phase 4 Mirapex ER
18 Clinical Trial to Evaluate the Efficacy of FITOGYN Versus Placebo on the Vasomotor Symptomatology Associated With Menopause Unknown status NCT01116310 Phase 4 Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L);Placebo
19 Imipramine and Pregabalin Combination in Painful Polyneuropathy Unknown status NCT01047488 Phase 4 Imipramine;Pregabalin;Imipramine, pregabalin;Placebo
20 Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy Unknown status NCT01328652 Phase 4 dexlansoprazole
21 Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans Unknown status NCT01662297 Phase 4 Quetiapine;Trazodone
22 Effects of Gabapentin Enacarbil on Arousals, Heart Rate, Blood Pressure and PLMs in Restless Legs Syndrome Unknown status NCT02424695 Phase 4 Gabapentin Enacarbil (GEn);Placebo
23 Effect of Atomoxetine on ADHD-Related Insomnia in Children and Adolescents Unknown status NCT00252278 Phase 4 atomoxetine
24 Benefit of One Month Zopiclone Intake on Adaptative Servoventilation Compliance Unknown status NCT02820441 Phase 4 Zopiclone;Placebo
25 A Six Week, Randomized, Double-Blind Placebo-Controlled, Suvorexant Augmentation Study of Antidepressant Treatment of Major Depressive Disorder With Residual Insomnia Unknown status NCT02669030 Phase 4 suvorexant;Placebo
26 Effect of Nasal CPAP on Lipid Profile in Patients With Dyslipidaemia and Sleep Apnea Unknown status NCT02557412 Phase 4
27 CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients. Unknown status NCT01771406 Phase 4 Nebivolol
28 Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic Unknown status NCT02699125 Phase 4 Guanfacine;Hydrochlorothiazide
29 Intermittent Hypoxia 2: Cardiovascular and Metabolism Unknown status NCT02058823 Phase 4 Placebo;Placebo;Valsartan;Amlodipine
30 Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving CPAP Compliance in Low Cardiovascular Risk Sleep Apnea Patients : OPTISAS 1 Study Unknown status NCT01796769 Phase 4
31 PROMAD: Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea Unknown status NCT01532050 Phase 4
32 Blood Pressure Reduction Induced by CPAP in Sleep Apnea Patients at High Cardiovascular Risk : OPTISAS 2 Study Unknown status NCT01505959 Phase 4
33 Comparison of the Pentax AWS® With the Macintosh Laryngoscopic Intubation in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01428570 Phase 4
34 Brain Mechanisms and Targeting Insomnia in Major Depression Unknown status NCT00628914 Phase 4 escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
35 Cost-utility Study of Continuous Positive Airway Pressure Treatment in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01590420 Phase 4
36 Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients Unknown status NCT01524510 Phase 4
37 Donepezil Treatment for Sleep Apnea Patients Unknown status NCT00912457 Phase 4 donepezil;placebo
38 Study on Magnetic Field Therapy to Improve Quality of Sleep and Reduction of Chronic Spine Pain Unknown status NCT00445133 Phase 4
39 Continuous Positive Airway Pressure in Sleep Apnea Syndrome: Effects on Metabolic Syndrome and Cardiac Damage Unknown status NCT00517777 Phase 4
40 Effects of Zolpidem CR® in Sleep and Heart Recovery in Cardiac Intensive Care Unit Patients Unknown status NCT01920334 Phase 4 Zolpidem CR 12.5mg;Placebo
41 Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression Unknown status NCT00291239 Phase 4
42 Sleep Disorders and Gastroesophageal Reflux Disease (GERD) Completed NCT00287391 Phase 4 Rabeprazole
43 Atripla to Stribild Switch Study to Evaluate Sleep Disturbances Completed NCT02477527 Phase 4 Stribild
44 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed NCT01234675 Phase 4 Milnacipran;Milnacipran
45 Effects of Rasagiline on Sleep Disturbances in Parkinson's Disease Completed NCT01442610 Phase 4 Rasagiline;Placebo
46 A Phase IV Trial With Pramipexole to Investigate the Effects on RLS Symptoms and Sleep Disturbance in Patients With RLS Completed NCT00349531 Phase 4 Pramipexole
47 Vonoprazan Study of Investigating the Effect on Sleep Disturbance Associated With Reflux Esophagitis- Exploratory Evaluation Completed NCT03116841 Phase 4 Vonoprazan
48 An Efficacy and Safety Study of Hydromorphone Oral Osmotic System (OROS) in Korean Participants With Cancer Pain Completed NCT00766831 Phase 4 Hydromorphone
49 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg qd and 40 mg qd to Placebo qd in Patients With Heartburn and Sleep Disturbances Associated With Gastroesophageal Reflux Disea Completed NCT00628342 Phase 4 Esomeprazole;Esomeprazole;Placebo
50 Eszopiclone for Sleep Disturbance and Nightmares in Post-Traumatic Stress Disorder Completed NCT00120250 Phase 4 Eszopiclone

Search NIH Clinical Center for Sleep Disorder

Inferred drug relations via UMLS 73 / NDF-RT 51 :
Sources

Genetic Tests for Sleep Disorder

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Sources

Anatomical Context for Sleep Disorder

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MalaCards organs/tissues related to Sleep Disorder:

41
Heart, Brain, Testes, Lung, Endothelial, Kidney, Liver
Sources

Publications for Sleep Disorder

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Articles related to Sleep Disorder:

(show top 50) (show all 641)
# Title Authors Year
1
Zaleplon loaded bi-layered chronopatch: A novel buccal chronodelivery approach to overcome circadian rhythm related sleep disorder. ( 29526622 )
2018
2
Sleep Disorders and Their Management in Children With Ehlers-Danlos Syndrome Referred to Sleep Clinics. ( 29609717 )
2018
3
Prevalence and characteristics of sleep-disordered breathing in familial dysautonomia. ( 29680425 )
2018
4
Sleep disorders in children with incidental pineal cyst on MRI: aA pilotA study. ( 29906628 )
2018
5
Sleep disorder prevalence in at-risk adolescents and potential effects of nightmare triad syndrome. ( 29453926 )
2018
6
The association of neck circumference with incident congestive heart failure and coronary heart disease mortality in a community-based population with or without sleep-disordered breathing. ( 29855261 )
2018
7
The risk of alopecia areata and other related autoimmune diseases in patients with sleep disorders: a Korean population-based retrospective cohort study. ( 29955877 )
2018
8
N-WRETS: Near-Lossless Wireless Real-time Efficient Electroencephalogram Transmission Solution to Support Sleep Disorder Monitoring Platforms. ( 29877756 )
2018
9
Chronic thromboembolic pulmonary hypertension: Reversal of pulmonary hypertension but not sleep disordered breathing following pulmonary endarterectomy. ( 29776563 )
2018
10
Sleep disorder risk factors among student athletes. ( 29530373 )
2018
11
Shift work and sleep disorder comorbidity tend to go hand in hand. ( 29157012 )
2018
12
Association of sleep-disordered breathing with severe chronic vascular disease in patients with type 2 diabetes. ( 29859478 )
2018
13
Association between Long-term Exposure to Air Pollution and Sleep Disorder in Chinese Children: The Seven Northeastern Cities (SNEC) Study. ( 29939357 )
2018
14
An analysis of whether sleep disorder will result in postpartum depression. ( 29861873 )
2018
15
Clinical impact of physical exercise on sleep disorder as assessed by actigram in patients with chronic pancreatitis: a study protocol for a randomised controlled trial. ( 29527314 )
2018
16
Sleep disorders in children with brain tumors: a pilot study based on a sleep disorder questionnaire. ( 29700571 )
2018
17
Association between obesity and sleep disorders in postmenopausal women. ( 28926516 )
2018
18
The Sleep Disorder in Anti-lgLON5 Disease. ( 29796717 )
2018
19
Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice. ( 29288667 )
2018
20
Assessing the sleeping habits of patients in a sleep disorder centre: a review of sleep diary accuracy. ( 29445542 )
2018
21
Severe obstructive sleep disorders in Prader-Willi syndrome patients in southern Italy. ( 29318372 )
2018
22
Non-Apnea Sleep Disorder Increases the Risk of Subsequent Female Infertility-A Nationwide Population-Based Cohort Study. ( 29136234 )
2018
23
The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. ( 29908682 )
2018
24
Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis. ( 29652034 )
2018
25
Sleep-disordered breathing in hospitalized patients with congestive heart failure: a concise review and proposed algorithm. ( 29850982 )
2018
26
Sleep disorder and altered locomotor activity as biomarkers of the Parkinson's disease cholinopathy in rat. ( 29170000 )
2018
27
Cost-effectiveness of cognitive-behavioural therapy for sleep disorder added to usual care in patients with schizophrenia: the BEST study. ( 29971156 )
2018
28
The clinical usefulness of a self-administered questionnaire for sleep-disordered breathing in patients with neuromuscular disease. ( 29445539 )
2018
29
Restless Sleep Disorder in Children: A Pilot Study on a Tentative New Diagnostic Category. ( 29771368 )
2018
30
REM sleep disorder following general anesthesia in rats. ( 27771371 )
2017
31
Epilepsy and sleep disorders improve in adolescents and adults with Angelman syndrome: A multicenter study on 46 patients. ( 28827041 )
2017
32
Dante Alighieri: evidence for sleep disorder-related cardiac autonomic dysfunctions. ( 28000594 )
2017
33
Sleep Disordered Breathing and Magnetic Resonance Imaging Findings in Children With Chiari Malformation Type I. ( 28943363 )
2017
34
Sleep-Disordered Breathing During Congestive Heart Failure: To Intervene or Not to Intervene? ( 29387467 )
2017
35
Refractory sleep-disordered breathing due to unilateral lingual tonsillar hypertrophy in a child with Proteus Syndrome. ( 28576518 )
2017
36
Predictors of failure of DISE-directed adenotonsillectomy in children with sleep disordered breathing. ( 28476166 )
2017
37
The Functional Impact of Sleep Disorders in Children With ADHD. ( 28093033 )
2017
38
Obesity, Cardiovascular Disease and Sleep Disorders: Insights into the Rising Epidemic. ( 28638745 )
2017
39
Dissociation of Objective and Subjective Daytime Sleepiness and Biomarkers of Systemic Inflammation in Sleep-Disordered Breathing and Systolic Heart Failure. ( 29065958 )
2017
40
Trauma associated sleep disorder: A parasomnia induced by trauma. ( 28363448 )
2017
41
Sleep Disorder as a Triggering Factor for Relapse in Multiple Sclerosis. ( 28359058 )
2017
42
Hyperbaric oxygen therapy is safe and effective for the treatment of sleep disorders in children with cerebral palsy. ( 28079475 )
2017
43
Risk factors of sleep disorder after stroke: a meta-analysis. ( 27686181 )
2017
44
Sleep Disorder Diagnosis During Pregnancy and Risk of Preterm Birth. ( 28796676 )
2017
45
Sleep Disorders, Restless Legs Syndrome, and Uremic Pruritus: Diagnosis and Treatment of Common Symptoms in DialysisA Patients. ( 27693261 )
2017
46
Spa therapy (balneotherapy) relieves mental stress, sleep disorder, and general health problems in sub-healthy people. ( 28936572 )
2017
47
The influence of sleep disordered breathing in REM sleep behavior disorder. ( 28673760 )
2017
48
Serum brain-derived neurotrophic factor levels and sleep disorders in Chinese healthy and newly diagnosed type 2 diabetic subjects. ( 27038292 )
2017
49
Sleep disorder, an independent risk associated with arterial stiffness in menopause. ( 28507296 )
2017
50
Feasibility of a respiratory nurse specialist-led sleep disorder service in a district general hospital. ( 28675190 )
2017
Sources

Variations for Sleep Disorder

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Expression for Sleep Disorder

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Search GEO for disease gene expression data for Sleep Disorder.
Sources

Pathways for Sleep Disorder

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Pathways related to Sleep Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
2
Circadian rhythm 37
Show member pathways
 10.97 CRY1 PER2 PER3
3
Melatonin metabolism and effects 1
10.7 CRY1 PER2 PER3
Sources

GO Terms for Sleep Disorder

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Biological processes related to Sleep Disorder according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 rhythmic process GO:0048511 9.7 CRY1 PER2 PER3
2 glucose homeostasis GO:0042593 9.67 CRY1 LEP TFAP2B
3 regulation of insulin secretion GO:0050796 9.61 LEP PER2 TFAP2B
4 circadian regulation of gene expression GO:0032922 9.58 CRY1 PER2 PER3
5 neuropeptide signaling pathway GO:0007218 9.56 HCRT HCRTR1 HCRTR2 NPS
6 positive regulation of JAK-STAT cascade GO:0046427 9.54 LEP PRL
7 response to peptide GO:1901652 9.51 HCRTR1 HCRTR2
8 feeding behavior GO:0007631 9.5 HCRT HCRTR1 HCRTR2
9 negative regulation of lipid storage GO:0010888 9.48 CRP LEP
10 negative regulation of circadian rhythm GO:0042754 9.46 CRY1 PER2
11 circadian rhythm GO:0007623 9.46 CRY1 LEP PER2 PER3
12 magnesium ion homeostasis GO:0010960 9.37 ANK3 TFAP2B
13 entrainment of circadian clock by photoperiod GO:0043153 9.13 CRY1 PER2 PER3
14 regulation of circadian sleep/wake cycle, sleep GO:0045187 8.8 HCRTR1 HCRTR2 PER3

Molecular functions related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription corepressor binding GO:0001222 9.16 PER2 PER3
2 orexin receptor activity GO:0016499 8.96 HCRTR1 HCRTR2
3 transcription factor activity, transcription factor binding GO:0000989 8.8 CRY1 PER2 PER3
Sources

Sources for Sleep Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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