Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: SLP005
MIFTS: 61

Sleep Disorder

Categories: Mental diseases, Neuronal diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Sleep Disorder

About this section

MalaCards integrated aliases for Sleep Disorder:

Name: Sleep Disorder 12 15 17
Sleep Disorders 42 15 70 32
Non-Organic Sleep Disorder 12 70
Sleep Dysfunction 6

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Mental diseases Neuronal diseases Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:535
ICD9CM 34 307.4
UMLS 70 C0154564 C0154565 C0851578
Sources

Summaries for Sleep Disorder

About this section
MedlinePlus : 42 What is sleep? Sleep is a complex biological process. While you are sleeping, you are unconscious, but your brain and body functions are still active. They are doing a number of important jobs that help you stay healthy and function at your best. So when you don't get enough quality sleep, it does more than just make you feel tired. It can affect your physical and mental health, thinking, and daily functioning. What are sleep disorders? Sleep disorders are conditions that disturb your normal sleep patterns. There are more than 80 different sleep disorders. Some major types include Insomnia - being unable to fall asleep and stay asleep. This is the most common sleep disorder. Sleep apnea - a breathing disorder in which you stop breathing for 10 seconds or more during sleep Restless leg syndrome (RLS) - a tingling or prickly sensation in your legs, along with a powerful urge to move them Hypersomnia - being unable to stay awake during the day. This includes narcolepsy, which causes extreme daytime sleepiness. Circadian rhythm disorders - problems with the sleep-wake cycle. They make you unable to sleep and wake at the right times. Parasomnia - acting in unusual ways while falling asleep, sleeping, or waking from sleep, such as walking, talking, or eating Some people who feel tired during the day have a true sleep disorder. But for others, the real problem is not allowing enough time for sleep. It's important to get enough sleep every night. The amount of sleep you need depends on several factors, including your age, lifestyle, health, and whether you have been getting enough sleep recently. Most adults need about 7-8 hours each night. What causes sleep disorders? There are different causes for different sleep disorders, including Other conditions, such as heart disease, lung disease, nerve disorders, and pain Mental illnesses, including depression and anxiety Medicines Genetics Sometimes the cause is unknown. There are also some factors that can contribute to sleep problems, including Caffeine and alcohol An irregular schedule, such as working the night shift Aging. As people age, they often get less sleep or spend less time in the deep, restful stage of sleep. They are also more easily awakened. What are the symptoms of sleep disorders? The symptoms of sleep disorders depend on the specific disorder. Some signs that you may have a sleep disorder include that You regularly take more than 30 minutes each night to fall asleep You regularly wake up several times each night and then have trouble falling back to sleep, or you wake up too early in the morning You often feel sleepy during the day, take frequent naps, or fall asleep at the wrong times during the day Your bed partner says that when you sleep, you snore loudly, snort, gasp, make choking sounds, or stop breathing for short periods You have creeping, tingling, or crawling feelings in your legs or arms that are relieved by moving or massaging them, especially in the evening and when trying to fall asleep Your bed partner notices that your legs or arms jerk often during sleep You have vivid, dreamlike experiences while falling asleep or dozing You have episodes of sudden muscle weakness when you are angry or fearful, or when you laugh You feel as though you cannot move when you first wake up How are sleep disorders diagnosed? To make a diagnosis, your health care provider will use your medical history, your sleep history, and a physical exam. You may also have a sleep study (polysomnogram). The most common types of sleep studies monitor and record data about your body during a full night of sleep. The data includes Brain wave changes Eye movements Breathing rate Blood pressure Heart rate and electrical activity of the heart and other muscles Other types of sleep studies may check how quickly you fall asleep during daytime naps or whether you are able to stay awake and alert during the day. What are the treatments for sleep disorders? Treatments for sleep disorders depend on which disorder you have. They may include Good sleep habits and other lifestyle changes, such as a healthy diet and exercise Cognitive behavioral therapy or relaxation techniques to reduce anxiety about getting enough sleep CPAP (continuous positive airway pressure) machine for sleep apnea Bright light therapy (in the morning) Medicines, including sleeping pills. Usually, providers recommend that you use sleeping pills for a short period of time. Natural products, such as melatonin. These products may help some people but are generally for short-term use. Make sure to check with your health care provider before you take any of them.

MalaCards based summary : Sleep Disorder, also known as sleep disorders, is related to sleep apnea and narcolepsy, and has symptoms including seizures, tremor and fever. An important gene associated with Sleep Disorder is GRIN2B (Glutamate Ionotropic Receptor NMDA Type Subunit 2B), and among its related pathways/superpathways are Neuroscience and AMP-activated Protein Kinase (AMPK) Signaling. The drugs Tramadol and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

Disease Ontology : 12 A disease of mental health that involves disruption of sleep patterns.

Wikipedia : 73 A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person. Some sleep... more...

Sources

Related Diseases for Sleep Disorder

About this section

Diseases in the Sleep Disorder family:

Rare Sleep Disorder

Diseases related to Sleep Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 543)
# Related Disease Score Top Affiliating Genes
1 sleep apnea 32.4 LEP INS HCRT
2 narcolepsy 32.4 MOG LEP HCRTR2 HCRTR1 HCRT
3 advanced sleep phase syndrome, familial, 1 32.4 PER3 PER2 CRY1 ARNTL
4 delayed sleep phase disorder 32.4 PER3 PER2 HCRT CRY1 ARNTL
5 advanced sleep phase syndrome 32.3 PER3 PER2 HCRTR2 HCRT CRY1 ARNTL
6 rem sleep behavior disorder 32.3 PER2 MAPT HCRT ARNTL
7 periodic limb movement disorder 32.2 HCRTR2 HCRT
8 narcolepsy 1 32.0 MOG HCRT
9 fatal familial insomnia 31.0 PER2 MAPT HCRT
10 body mass index quantitative trait locus 11 31.0 PER2 LEP INS HCRTR2 HCRT ARNTL
11 apnea, obstructive sleep 30.8 LEP INS HCRT
12 attention deficit-hyperactivity disorder 30.7 PRL PER2 MOG GRIN2B CRY1 ARNTL
13 eating disorder 30.7 LEP HCRTR1 HCRT
14 anxiety 30.7 PRL INS HCRTR1 HCRT GRIN2B ADORA1
15 mental depression 30.6 INS GRIN2B ARNTL
16 prader-willi syndrome 30.6 PRL LEP INS HCRT
17 autism 30.6 SLC9A6 PRL MAPT LEP HCRT GRIN2B
18 migraine with or without aura 1 30.5 PRL LEP INS HCRTR2 HCRT GRIN2B
19 dystonia 30.5 PRL INS HCRT GRIN2B GCH1
20 amenorrhea 30.5 PRL LEP INS
21 choreatic disease 30.5 SLC9A6 GRIN2B GCH1
22 disease of mental health 30.4 SLC9A6 PRL PER3 PER2 MOG MAPT
23 schizophrenia 30.3 PRL MOG MAPT LEP INS HCRT
24 bipolar i disorder 30.3 PER3 ARNTL ANK3
25 substance abuse 30.2 PRL MOG INS
26 hypopituitarism 30.2 PRL LEP INS
27 hyperthyroidism 30.2 PRL LEP INS
28 bipolar disorder 30.1 PRL PER3 PER2 MAPT LEP GRIN2B
29 focal epilepsy 30.1 PRL MAPT GRIN2B
30 major depressive disorder 30.1 PRL PER3 PER2 LEP HCRTR1 HCRT
31 non 24 hour sleep wake disorder 11.2
32 machado-joseph disease 11.1
33 rare sleep disorder 11.0
34 idiopathic hypersomnia 11.0
35 neurodevelopmental disorder with severe motor impairment and absent language 11.0
36 hypersomnia 10.9
37 dementia, lewy body 10.9
38 brunner syndrome 10.9
39 chromosome 1q21.1 deletion syndrome, 1.35-mb 10.9
40 multiple personality disorder 10.9
41 pure autonomic failure 10.9
42 lyme disease - neurological complications 10.9
43 bruxism 10.9
44 progeroid short stature with pigmented nevi 10.8
45 short sleep, familial natural, 1 10.8
46 narcolepsy 7 10.8
47 mental retardation, autosomal recessive 37 10.8
48 recurrent hypersomnia 10.8
49 rohhad 10.5 HCRTR2 HCRTR1 HCRT
50 von economo's disease 10.5 HCRTR2 HCRTR1 HCRT

Graphical network of the top 20 diseases related to Sleep Disorder:



Diseases related to Sleep Disorder
Sources

Symptoms & Phenotypes for Sleep Disorder

About this section

UMLS symptoms related to Sleep Disorder:


seizures; tremor; fever; back pain; dyspnea; vertigo; cachexia; headache; syncope; cyanosis; edema; pain; chronic pain; sciatica; snoring; sleep disturbances; icterus; signs and symptoms; signs and symptoms, digestive; hot flushes; vertigo/dizziness; sleeplessness; nervousness; psychiatric symptom; sluggishness; nightmares; hallucinations, hypnagogic

MGI Mouse Phenotypes related to Sleep Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.43 ADORA1 ANK3 ARNTL CRY1 DHX30 GCH1
2 homeostasis/metabolism MP:0005376 10.24 ADORA1 ARNTL ASXL3 CRY1 DHX30 GCH1
3 growth/size/body region MP:0005378 10.22 ADORA1 ARNTL CRY1 DHX30 GCH1 GRIN2B
4 cardiovascular system MP:0005385 10.13 ADORA1 ARNTL CRY1 GCH1 HCRT INS
5 nervous system MP:0003631 10.13 ADORA1 ANK3 ARNTL CRY1 DHX30 GCH1
6 integument MP:0010771 9.97 ADORA1 ARNTL CRY1 INS LEP MAPT
7 muscle MP:0005369 9.91 ARNTL CRY1 HCRT HCRTR2 INS LEP
8 renal/urinary system MP:0005367 9.56 ADORA1 ANK3 ARNTL INS LEP MAPT
9 vision/eye MP:0005391 9.28 ARNTL CRY1 INS LEP MAPT MOG
Sources

Drugs & Therapeutics for Sleep Disorder

About this section

Drugs for Sleep Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 253)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
2
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
3
Montelukast Approved Phase 4 158966-92-8 5281040
4
Levocetirizine Approved Phase 4 130018-77-8 1549000
5
Pantoprazole Approved Phase 4 102625-70-7 4679
6
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
7
Norepinephrine Approved Phase 4 51-41-2 439260
8
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
9
Citalopram Approved Phase 4 59729-33-8 2771
10
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
11
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
12
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
13
Suvorexant Approved, Investigational Phase 4 1030377-33-3
14
Losartan Approved Phase 4 114798-26-4 3961
15
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
16
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
17
Zolpidem Approved Phase 4 82626-48-0 5732
18
Promethazine Approved, Investigational Phase 4 60-87-7 4927
19
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
20
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
21
Buspirone Approved, Investigational Phase 4 36505-84-7 2477
22
Apomorphine Approved, Investigational Phase 4 58-00-4, 41372-20-7 6005
23
Iron Approved Phase 4 7439-89-6 23925 29936
24
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
25
Pramipexole Approved, Investigational Phase 4 104632-26-0 59868 119570
26
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
27
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
28
Testosterone Approved, Investigational Phase 4 58-22-0 6013
29
Leuprolide Approved, Investigational Phase 4 53714-56-0 3911 657181
30
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
31
Dexetimide Withdrawn Phase 4 21888-98-2
32
2,4-thiazolidinedione Investigational Phase 4 2295-31-0
33 Hormones Phase 4
34 Respiratory System Agents Phase 4
35 Anesthetics, Dissociative Phase 4
36 Excitatory Amino Acid Antagonists Phase 4
37 Anti-Asthmatic Agents Phase 4
38 Leukotriene Antagonists Phase 4
39 Histamine H1 Antagonists, Non-Sedating Phase 4
40 Antacids Phase 4
41 Anti-Ulcer Agents Phase 4
42 Proton Pump Inhibitors Phase 4
43 Coagulants Phase 4
44 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
45 Serotonin Uptake Inhibitors Phase 4
46 Cytochrome P-450 Enzyme Inhibitors Phase 4
47 Analgesics, Non-Narcotic Phase 4
48 Anti-Bacterial Agents Phase 4
49 Antibiotics, Antitubercular Phase 4
50 Antihypertensive Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 585)
# Name Status NCT ID Phase Drugs
1 Pilot Study: The Effect of Rozerem on Sleep Disturbance After Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
2 Sleep Disturbances in Hospitalized Children Unknown status NCT00749814 Phase 4
3 Comparison of Effect of Peritonsillar Infiltration of Ketamine and Tramadol on Pediatric Posttonsillectomy Pain: A Double-blinded Randomized Placebo-controlled Clinical Trial Unknown status NCT03067103 Phase 4 Tramadol;Ketamine;Placebos
4 Sleep Disordered Breathing in TIA/Ischemic Stroke: Effects on Short- and Long-term Outcome and CPAP Treatment Efficacy: an Open, Observational, Clinical, Multicentre Trial With a Randomized Arm Unknown status NCT01097967 Phase 4
5 The Effect of Nasal CPAP in Patients With Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
6 Inflammatory Response to Anti Inflammatory Therapy in Children With Sleep Disordered Breathing Unknown status NCT00299910 Phase 4 Montelukast
7 Are Patients Suffering From DSPS Show Compromising in Everyday Functions and Abilities (Attention and Concentration, Mood and Fatigue) Before Handling the Disorder? And Whether the Treatment Fixes the Disorder? Unknown status NCT02962037 Phase 4
8 Placebo Controlled Pilot Study on the Efficacy of Levocetirizine 5 mg in Reducing Symptoms, Airway Resistance, and Sleep Impairment in Patients With Persistent Allergic Rhinitis Completed NCT00355771 Phase 4 Levocetirizine;Placebo
9 Eszopiclone and Inflammatory Mediators in Patients With Acute Coronary Syndrome Completed NCT00822679 Phase 4 Eszopiclone
10 Paroxetine in the Treatment of Chronic Primary Insomnia: A Double-Blind, Randomized, Placebo-Controlled Study of Efficacy Over Six Weeks Completed NCT00178048 Phase 4 paroxetine
11 The Effects of a Parental Intervention on Electronic Media Exposure and Sleep Patterns in Adolescents Completed NCT02365025 Phase 4
12 Stacking Exercises Attenuate the Decline in Forced Vital Capacity and Sick Time (STEADFAST) Completed NCT01999075 Phase 4
13 Efficacy and Safety Assessment of ZOlpidem (Stilnox CR) Administered on as Needed Basis in Patients With Chronic insomNIA Completed NCT01024192 Phase 4 ZOLPIDEM SL800750
14 Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome With Major Depressive Disorder or Dysthymic Disorder Completed NCT00518986 Phase 4 armodafinil;placebo
15 National, Multicenter, Open Label, Phase IV, Before-after Design Study, in Adult Patients With Primary Insomnia to Evaluate Sleep Satisfaction and Psychomotor Performance After 1 Month of Treatment With Zolpidem CR (Ambien®CR) in 6 Sites in Argentina Completed NCT01097382 Phase 4 ZOLPIDEM
16 Effect of Zolpidem vs Placebo on Insomnia and Daytime Function in Patients With Insomnia Associated With Osteoarthritis Completed NCT00530556 Phase 4 zolpidem
17 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed NCT01234675 Phase 4 Milnacipran;Placebo
18 Psychobiology and Treatment Response in Primary Insomnia Completed NCT00177216 Phase 4 Zolpidem;Escitalopram;Placebo
19 A Randomized Placebo-controlled Trial Evaluating the Effect of Melatonin on Sleep Quality in Patients With Dementia Completed NCT03066518 Phase 4 Melatonin 5 mg
20 The Impact of Gastroesophageal Reflux Disease in Sleep Disorders: A Pilot Investigation of Rabeprazole, 20 mg Twice Daily for the Relief of GERD-Related Insomnia. Completed NCT00287391 Phase 4 Rabeprazole
21 Examination of the Effectiveness of Suvorexant in Improving Daytime Sleep in Shift Workers Completed NCT02491788 Phase 4 Suvorexant;Placebo
22 Assessments in Stress and Quality of Sleep/Life in Night-shift Nurses and Doctors Completed NCT02541747 Phase 4
23 A Double-Blind Placebo-Controlled, Randomized, Parallel-Group, Single-Site Study of Mometasone Furoate Nasal Spray (MFNS) In Subjects With Sleep-disordered Breathing Associated With Perennial Allergic Rhinitis (PAR) Using Home-Monitored Cardio-Respiratory Methodology. Completed NCT00359216 Phase 4 Mometasone furoate nasal spray;Placebo
24 Randomized, Placebo-Controlled Trial of Pantoprazole for Sleepiness Associated With Acid Reflux and Obstructive Sleep Disordered Breathing Completed NCT00307944 Phase 4 Pantoprazole
25 Randomized, Placebo-Controlled Multicenter Trial of the Effects of Orally Administered Xyrem (Sodium Oxybate) and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients Completed NCT00086281 Phase 4 Xyrem (X);Zolpidem (Z);Modafinil (M);Placebo (P)
26 Screening for Sleep-disordered Breathing in Routine Cardiology Practice: Validation of the Apnea + Hypopnea Detection by an Implantable Cardioverter Defibrillator (ICD) or Cardiac Resynchronization Therapy-defibrillator (CRT-D) With Impedance-based Respiration Sensor (ApneaScanTM) Completed NCT02045173 Phase 4
27 Sleep and Breathing in Health and Disease (Part 2A - Chemical Stimuli, Sleep and Breathing in the General Population) Completed NCT04720547 Phase 4 Zolpidem
28 Effect of Angiotensin Receptor Blockers on Periodic Breathing During Sleep in Hypoxia Completed NCT03335904 Phase 4 Losartan;Placebo
29 Delayed Sleep Phase Syndrome in Adolescents and Young Adults. Sleep, Personality, Developmental History, Circadian Rhythm, Daytime Functioning and Treatment Completed NCT00834886 Phase 4
30 A Single Dose, Open-Label, Randomized Two-Period Crossover Study in Healthy Young Subjects to Assess the Absolute Bioavailability of Tasimelteon (HETLIOZâ„¢) Completed NCT02130999 Phase 4 tasimelteon 20 mg capsule;tasimelteon 2 mg I.V.
31 A Randomized Controlled Trial of Telephone-delivered Cognitive Behavioral-therapy, Modafinil, and Combination Therapy of Both Interventions for Fatigue in Multiple Sclerosis Recruiting NCT03621761 Phase 4 Modafinil
32 Central Sleep Apnea: Physiologic Mechanisms to Inform Treatment Recruiting NCT04118387 Phase 4 Acetazolamide + supplemental oxygen + PAP therapy;Zolpidem + PAP therapy;Buspirone + PAP therapy
33 Double Bind Randomized Placebo-controlled Cross-over Study to Evaluate Effect of Continuous Apomorphine During the Night on Sleep Disorders in Insomniac Patients With Parkinson's Disease Active, not recruiting NCT02940912 Phase 4 Apomorphine;Placebo
34 Effect of Acetazolamide on Sleep Disordered Breathing in Lowlanders Older Than 40 Years at Altitude: A Randomized, Placebo-controlled, Double-blind Parallel Trial Active, not recruiting NCT03536507 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule
35 Optimum Frequency and Timing of Oral Iron Administration for Childhood Restless Leg Syndrome/Periodic Limb Movement Disorder Enrolling by invitation NCT04610827 Phase 4 Ferrous sulfate
36 Yangzheng Compound Mixture in the Treatment of Sleep Disorder in Cancer Patients With Qi-Yin Deficiency Syndrome During Chemotherapy: a Multicenter, Randomized, Prospective, Real-world Study Not yet recruiting NCT04641819 Phase 4 Yangzheng Compound Mixture
37 A Multicenter, Randomized, Double-blind, Placebo-controlled Study: Evaluation of the Efficacy and Safety of Agomelatine in the Treatment of Sleep Disorders and Depression in Patients With Parkinson's Disease Not yet recruiting NCT03977441 Phase 4 Agomelatine or PIacebo
38 A Parallel, Double-blind Comparison of Tolterodine vs. Placebo Treatments for Nocturia in Postmenopausal Women. Terminated NCT00323635 Phase 4 tolterodine
39 Sleep, Metabolic, and Cardiovascular Dysfunction in Polycystic Ovary Syndrome Terminated NCT00203996 Phase 4 depot leuprolide plus estrogen/progestin replacement;pioglitazone
40 Controlled-Release Melatonin (Melatonin CR)for the Treatment of Impaired Sleep Maintenance (ISM) in 4-8 Year Old Children With Autism Spectrum Disorders (ASD). Terminated NCT01033565 Phase 4 Natrol
41 Intranasal Steroids for the Treatment of Nocturnal Enuresis With Associated Obstructive Sleep Apnea Withdrawn NCT01861145 Phase 4 Nasonex
42 Effects of Cognitive-Behavioral Therapy on Sleep Disturbance in Peritoneal Dialysis Patients Unknown status NCT00155441 Phase 3
43 A Randomized, Prospective, Double Blind, Placebo-Controlled Trial of Two Different Doses of Oral Melatonin Supplements in Chronic Kidney Disease (CKD)-Associated Sleep Disorders Unknown status NCT01922999 Phase 2, Phase 3 Melatonin
44 Mirtazapine for the Treatment of Sleep Disorders in Alzheimer's Disease: a Randomized, Double-blind, Placebo-controlled Study Unknown status NCT01867775 Phase 3 Mirtazapine
45 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
46 Open-Label Safety Study of a 1-Year 20 mg Dose Regimen of Tasimelteon for Treatment of Non-24-Hour-Sleep-Wake Disorder (N24HSWD) in Blind Individuals With No Light Perception Unknown status NCT01218789 Phase 3 tasimelteon
47 A 12-Week, Double-Blind, Placebo Controlled, Parallel Group Study to Assess the Efficacy and Safety of Ropinirole in Patients Suffering From Restless Legs Syndrome (RLS) Completed NCT00363857 Phase 3 Ropinirole
48 Investigating Cognitive Function for Patients Participating in the SOFT Trial in Selected Centers Completed NCT00659373 Phase 3 Tamoxifen;triptorelin;Exemestane
49 Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer Completed NCT00902330 Phase 3
50 The Use Of Valeriana Officinalis (Valerian) In Improving Sleep In Patients Who Are Undergoing Adjuvant Treatment For Cancer" A Phase III Randomized, Placebo-Controlled, Double-Blind Study Completed NCT00075842 Phase 3

Search NIH Clinical Center for Sleep Disorder

Inferred drug relations via UMLS 70 / NDF-RT 51 :


zolpidem
Zolpidem tartrate
Sources

Genetic Tests for Sleep Disorder

About this section
Sources

Anatomical Context for Sleep Disorder

About this section

MalaCards organs/tissues related to Sleep Disorder:

40
Eye, Heart, Brain, Spinal Cord, Pituitary, Liver, Ovary
Sources

Publications for Sleep Disorder

About this section

Articles related to Sleep Disorder:

(show top 50) (show all 14255)
# Title Authors PMID Year
1
Whole-genome sequencing of patients with rare diseases in a national health system. 6
32581362 2020
2
Prenatal and postnatal exposure to Tangshan earthquake and CRHR1 gene polymorphism influence risk of sleep disturbance in adulthood. 42
33725938 2021
3
Impact of rapid eye movement sleep behavior disorder and autonomic disorders on Parkinson's disease: a review. 42
33759983 2021
4
The association between perceived stress with sleep quality, insomnia, anxiety and depression in kidney transplant recipients during Covid-19 pandemic. 42
33684159 2021
5
Sleep disorders in Alzheimer's disease: the predictive roles and potential mechanisms. 61
33642368 2021
6
Neuroendocrine, neuroinflammatory and pathological outcomes of chronic stress: A story of microglial remodeling. 61
33587954 2021
7
The Association Between Dietary Zinc Intake and Health Status, Including Mental Health and Sleep Quality, Among Iranian Female Students. 61
32743763 2021
8
Oxidative stress in cardiac hypertrophy: From molecular mechanisms to novel therapeutic targets. 61
33675957 2021
9
Video-polysomnographic findings after acute COVID-19: REM sleep without atonia as sign of CNS pathology? 61
33588262 2021
10
Elevated risk of depression among adolescents presenting with sleep disorders. 61
33196433 2021
11
Sleep quality and sleep disturbances among volunteer and professional French firefighters: FIRESLEEP study. 61
33610069 2021
12
Sleep-related (psychogenic) dissociative disorders as parasomnias associated with a psychiatric disorder: update on reported cases. 61
33382034 2021
13
Dietary intake and menopausal symptoms in postmenopausal women: a systematic review. 61
33112163 2021
14
Efficacy and safety of modafinil in patients with idiopathic hypersomnia without long sleep time: a multicenter, randomized, double-blind, placebo-controlled, parallel-group comparison study. 61
33631500 2021
15
The Arousal Disorders Questionnaire: a new and effective screening tool for confusional arousals, Sleepwalking and Sleep Terrors in epilepsy and sleep disorders units. 61
33610075 2021
16
Restless sleep disorder in children with attention-deficit/hyperactivity disorder. 61
33155540 2021
17
Impact of methylphenidate on sleep problems in adults with ADHD: a pilot polysomnography study. 61
33100096 2021
18
Primary care providers perform more neurologic visits than neurologists among Medicare beneficiaries. 61
32754960 2021
19
Restless sleep in children: A systematic review. 61
33341437 2021
20
Sleep phenotype of individuals with autism spectrum disorder bearing mutations in the PER2 circadian rhythm gene. 61
33474825 2021
21
Autism Spectrum Disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin. 61
33657458 2021
22
Association of Sleep Quality With Greater Left Ventricular Mass in Children Aged 9 to 11 Years. 61
33534393 2021
23
Patient experiences of sleep in dialysis: systematic review of qualitative studies. 61
33571871 2021
24
Impact of EMA regulatory label changes on hydroxyzine initiation, discontinuation and switching to other medicines in Denmark, Scotland, England and the Netherlands: An interrupted time series regression analysis. 61
33386650 2021
25
Sleep disorders and cancer: State of the art and future perspectives. 61
33333427 2021
26
Subjective and polysomnographic evaluation of sleep in mitochondrial optic neuropathies. 61
32524698 2021
27
Altered ioflupane single-photon emission computed tomography in anti-IgLON5 disease: A new case mimicking probable progressive supranuclear palsy and review of the literature. 61
33175431 2021
28
The Toxicological Risk Assessment of Lead and Cadmium in Valeriana officinalis L., radix (Valerian root) as Herbal Medicinal Product for the Relief of Mild Nervous Tension and Sleep Disorders Available in Polish Pharmacies. 61
33792859 2021
29
Exploding head syndrome, chronotype, parasomnias and mental health in young adults. 61
32282101 2021
30
Sleep profile and Polysomnography in patients with drug-resistant temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) and the effect of epilepsy surgery on sleep-a prospective cohort study. 61
33601230 2021
31
Objective sleep data as predictors of cognitive decline in dementia with Lewy Bodies and Parkinson's disease. 61
33610074 2021
32
Effects of Epidural Anesthesia on Quality of Life in Elderly Patients Undergoing Esophagectomy. 61
32805363 2021
33
Comfort rules for face masks among healthcare workers during COVID-19 spread. 61
33797548 2021
34
Prevalence of and risk factors associated with sleep disturbances among HPCD exposed to COVID-19 in China. 61
33540240 2021
35
Two sides of a coin: differential response to COVID-19 distancing measures in children with narcolepsy. 61
33295278 2021
36
Sleep and Interpersonal Violence: A Systematic Review. 61
31131736 2021
37
Automatic identification of insomnia using optimal antisymmetric biorthogonal wavelet filter bank with ECG signals. 61
33631498 2021
38
Who Is Seeking Help for Sleep? A Clinical Profile of Patients in a Sleep Psychology Clinic. 61
32405918 2021
39
The influence of sleep disturbances and sleep disorders on pain outcomes among veterans: A systematic scoping review. 61
33348172 2021
40
Noise sensitivity associated with nonrestorative sleep in Chinese adults: a cross-sectional study. 61
33794830 2021
41
Cultural adaptations of psychological interventions for prevalent sleep disorders and sleep disturbances: A systematic review of randomized controlled trials in the United States. 61
33735638 2021
42
Sleep health in Indigenous Australian children: a systematic review. 61
33618099 2021
43
Alteration in the psychologic status and family environment of pregnant women before and during the COVID-19 pandemic. 61
33403679 2021
44
Combined melatonin and adrenocorticotropic hormone treatment attenuates N-methyl-d-aspartate-induced infantile spasms in a rat model by regulating activation of the HPA axis. 61
33571576 2021
45
Birds of a Feather Flock Together: Disadvantageous Decision Making in Augmented Restless Legs Syndrome Patients with and without Impulse Control Disorders. 61
33802756 2021
46
Autoimmune dysautonomia in women with silicone breast implants. 61
33799099 2021
47
A Primary Care Agenda for Brain Health: A Scientific Statement From the American Heart Association. 61
33719523 2021
48
Narcolepsy and psychosis: a systematic review. 61
33779983 2021
49
Brotizolam During Pregnancy and Lactation: Brotizolam Levels in Maternal Serum, Cord Blood, Breast Milk, and Neonatal Serum. 61
33666494 2021
50
Assessing Sleep Concerns in Individuals With Acquired Brain Injury: The Feasibility of a Smartpad Sleep Tool. 61
33706533 2021
Sources

Variations for Sleep Disorder

About this section

ClinVar genetic disease variations for Sleep Disorder:

6 (show all 11)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 overlap with 49 genes GRCh37/hg19 17p11.2(chr17:16782546-20294038) copy number loss Pathogenic 523256 GRCh37: 17:16782546-20294038
GRCh38:
2 DHX30 NM_138615.3(DHX30):c.1685A>G (p.His562Arg) SNV Pathogenic 402130 rs1060499733 GRCh37: 3:47888247-47888247
GRCh38: 3:47846757-47846757
3 GRIN2B NM_000834.5(GRIN2B):c.1439_1446del (p.Leu480fs) Deletion Pathogenic 916029 GRCh37: 12:13768481-13768488
GRCh38: 12:13615547-13615554
4 GCH1 NM_000161.3(GCH1):c.655C>T (p.Gln219Ter) SNV Likely pathogenic 523338 rs1555358382 GRCh37: 14:55310833-55310833
GRCh38: 14:54844115-54844115
5 SLC9A6 NM_001042537.1(SLC9A6):c.1299_1300del (p.Phe434fs) Deletion Likely pathogenic 418996 rs1064793575 GRCh37: X:135098865-135098866
GRCh38: X:136016706-136016707
6 ASXL3 NM_030632.3(ASXL3):c.4376del (p.Gly1459fs) Deletion Likely pathogenic 813001 rs1599573759 GRCh37: 18:31324184-31324184
GRCh38: 18:33744220-33744220
7 KIF4A NM_012310.5(KIF4A):c.1553G>C (p.Arg518Pro) SNV Uncertain significance 523498 rs766819113 GRCh37: X:69573536-69573536
GRCh38: X:70353686-70353686
8 DNMT1 NM_001130823.3(DNMT1):c.3362G>T (p.Ser1121Ile) SNV Uncertain significance 599001 rs1202584286 GRCh37: 19:10251813-10251813
GRCh38: 19:10141137-10141137
9 PCDH19 NM_001184880.2(PCDH19):c.2359C>T (p.Arg787Cys) SNV Uncertain significance 159556 rs376390125 GRCh37: X:99657779-99657779
GRCh38: X:100402781-100402781
10 CHAT NM_020549.4(CHAT):c.403C>T (p.Pro135Ser) SNV Uncertain significance 523530 rs1554802473 GRCh37: 10:50827786-50827786
GRCh38: 10:49619740-49619740
11 PER2 NM_022817.3(PER2):c.1793A>G (p.Asn598Ser) SNV Uncertain significance 977454 GRCh37: 2:239167024-239167024
GRCh38: 2:238258383-238258383
Sources

Expression for Sleep Disorder

About this section
Search GEO for disease gene expression data for Sleep Disorder.
Sources

Pathways for Sleep Disorder

About this section

Pathways related to Sleep Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
12.25 TFAP2B MAPT HCRT GRIN2B ARNTL
2
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.22 MAPT LEP INS CRY1
4
Signaling events mediated by PTP1B 1
11.28 PRL LEP INS
5
Diurnally Regulated Genes with Circadian Orthologs 1
11.23 PER2 CRY1 ARNTL
6
Circadian rhythm 36
Show member pathways
 11.09 PER3 PER2 CRY1 ARNTL
7
Melatonin metabolism and effects 1
10.82 PER3 PER2 CRY1 ARNTL
8
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.73 PRL LEP INS
9
Metabolic States and Circadian Oscillators 63
Show member pathways
 10.51 CRY1 ARNTL
Sources

GO Terms for Sleep Disorder

About this section

Cellular components related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 9.16 PRL INS
2 synapse GO:0045202 9.1 HCRTR2 HCRTR1 HCRT GRIN2B ANK3 ADORA1
3 axolemma GO:0030673 8.96 MAPT ADORA1

Biological processes related to Sleep Disorder according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.87 HCRTR2 HCRTR1 HCRT GRIN2B
2 neuropeptide signaling pathway GO:0007218 9.76 HCRTR2 HCRTR1 HCRT
3 positive regulation of cold-induced thermogenesis GO:0120162 9.75 PER2 LEP HCRT
4 rhythmic process GO:0048511 9.73 PER3 PER2 CRY1 ARNTL
5 excitatory postsynaptic potential GO:0060079 9.71 HCRT GRIN2B ADORA1
6 glucose metabolic process GO:0006006 9.7 TFAP2B LEP INS
7 regulation of synaptic plasticity GO:0048167 9.65 MAPT INS GRIN2B
8 glucose homeostasis GO:0042593 9.62 TFAP2B LEP INS CRY1
9 central nervous system neuron development GO:0021954 9.61 MAPT LEP
10 negative regulation of lipid catabolic process GO:0050995 9.61 INS ADORA1
11 negative regulation of gluconeogenesis GO:0045721 9.6 INS CRY1
12 fatty acid homeostasis GO:0055089 9.59 INS ADORA1
13 positive regulation of neuron death GO:1901216 9.58 MAPT GRIN2B ADORA1
14 negative regulation of circadian rhythm GO:0042754 9.56 PER2 CRY1
15 negative regulation of acute inflammatory response GO:0002674 9.55 INS ADORA1
16 feeding behavior GO:0007631 9.54 HCRTR2 HCRTR1 HCRT
17 negative regulation of blood vessel diameter GO:0097756 9.51 INS ADORA1
18 magnesium ion homeostasis GO:0010960 9.49 TFAP2B ANK3
19 negative regulation of glucocorticoid receptor signaling pathway GO:2000323 9.46 CRY1 ARNTL
20 circadian rhythm GO:0007623 9.46 PER2 LEP CRY1 ARNTL
21 entrainment of circadian clock by photoperiod GO:0043153 9.43 PER3 PER2 CRY1
22 regulation of insulin secretion GO:0050796 9.26 TFAP2B PER2 LEP ARNTL
23 circadian regulation of gene expression GO:0032922 8.92 PER3 PER2 CRY1 ARNTL

Molecular functions related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 PRL LEP INS
2 transcription corepressor binding GO:0001222 8.96 PER3 PER2
3 orexin receptor activity GO:0016499 8.62 HCRTR2 HCRTR1
Sources

Sources for Sleep Disorder

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....