MCID: SLP005
MIFTS: 59

Sleep Disorder

Categories: Mental diseases, Neuronal diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Sleep Disorder

Summaries for Sleep Disorder

MedlinePlus: 41 What is sleep? Sleep is a complex biological process. While you are sleeping, you are unconscious, but your brain and body functions are still active. They are doing a number of important jobs that help you stay healthy and function at your best. So when you don't get enough quality sleep, it does more than just make you feel tired. It can affect your physical and mental health, thinking, and daily functioning. What are sleep disorders? Sleep disorders are conditions that disturb your normal sleep patterns. There are more than 80 different sleep disorders. Some major types include: Insomnia - being unable to fall asleep and stay asleep. This is the most common sleep disorder. Sleep apnea - a breathing disorder in which you stop breathing for 10 seconds or more during sleep Restless leg syndrome (RLS) - a tingling or prickly sensation in your legs, along with a powerful urge to move them Hypersomnia - being unable to stay awake during the day. This includes narcolepsy, which causes extreme daytime sleepiness. Circadian rhythm disorders - problems with the sleep-wake cycle. They make you unable to sleep and wake at the right times. Parasomnia - acting in unusual ways while falling asleep, sleeping, or waking from sleep, such as walking, talking, or eating Some people who feel tired during the day have a true sleep disorder. But for others, the real problem is not allowing enough time for sleep. It's important to get enough sleep every night. The amount of sleep you need depends on several factors, including your age, lifestyle, health, and whether you have been getting enough sleep recently. Most adults need about 7-8 hours each night. What causes sleep disorders? There are different causes for different sleep disorders, including: Other conditions, such as heart disease, lung disease, nerve disorders, and pain Mental illnesses, including depression and anxiety Medicines Genetics Sometimes the cause is unknown. There are also some factors that can contribute to sleep problems, including: Caffeine and alcohol An irregular schedule, such as working the night shift Aging. As people age, they often get less sleep or spend less time in the deep, restful stage of sleep. They are also more easily awakened. What are the symptoms of sleep disorders? The symptoms of sleep disorders depend on the specific disorder. Some signs that you may have a sleep disorder include that: You regularly take more than 30 minutes each night to fall asleep You regularly wake up several times each night and then have trouble falling back to sleep, or you wake up too early in the morning You often feel sleepy during the day, take frequent naps, or fall asleep at the wrong times during the day Your bed partner says that when you sleep, you snore loudly, snort, gasp, make choking sounds, or stop breathing for short periods You have creeping, tingling, or crawling feelings in your legs or arms that are relieved by moving or massaging them, especially in the evening and when trying to fall asleep Your bed partner notices that your legs or arms jerk often during sleep You have vivid, dreamlike experiences while falling asleep or dozing You have episodes of sudden muscle weakness when you are angry or fearful, or when you laugh You feel as though you cannot move when you first wake up How are sleep disorders diagnosed? To make a diagnosis, your health care provider will use your medical history, your sleep history, and a physical exam. You may also have a sleep study (polysomnogram). The most common types of sleep studies monitor and record data about your body during a full night of sleep. The data includes: Brain wave changes Eye movements Breathing rate Blood pressure Heart rate and electrical activity of the heart and other muscles Other types of sleep studies may check how quickly you fall asleep during daytime naps or whether you are able to stay awake and alert during the day. What are the treatments for sleep disorders? Treatments for sleep disorders depend on which disorder you have. They may include: Good sleep habits and other lifestyle changes, such as a healthy diet and exercise Cognitive behavioral therapy or relaxation techniques to reduce anxiety about getting enough sleep CPAP (continuous positive airway pressure) machine for sleep apnea Bright light therapy (in the morning) Medicines, including sleeping pills. Usually, providers recommend that you use sleeping pills for a short period of time. Natural products, such as melatonin. These products may help some people but are generally for short-term use. Make sure to check with your health care provider before you take any of them.

MalaCards based summary: Sleep Disorder, also known as sleep disorders, is related to narcolepsy 1 and idiopathic hypersomnia, and has symptoms including tremor, fever and back pain. An important gene associated with Sleep Disorder is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are IL-9 Signaling Pathways and Peptide hormone metabolism. The drugs Tramadol and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and lung, and related phenotypes are nervous system and homeostasis/metabolism

Disease Ontology: 11 A disease of mental health that involves disruption of sleep patterns.

Wikipedia: 75 A sleep disorder, or somnipathy, is a medical disorder of an individual's sleep patterns. Some sleep... more...

Related Diseases for Sleep Disorder

Diseases in the Sleep Disorder family:

Rare Sleep Disorder

Diseases related to Sleep Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1043)
# Related Disease Score Top Affiliating Genes
1 narcolepsy 1 32.4 MOG HLA-DQB1 HCRT
2 idiopathic hypersomnia 32.4 HLA-DQB1 HCRT
3 rem sleep behavior disorder 32.3 SNCA SLC6A3 PER2 HCRT BMAL1
4 delayed sleep phase disorder 32.3 PER3 PER2 HCRT CRY1 CLOCK BMAL1
5 hypersomnia 32.3 HLA-DQB1 HCRT
6 periodic limb movement disorder 32.2 SLC6A3 PER3 PER2 HLA-DQB1 HCRTR2 HCRT
7 sleep apnea 32.2 TNF REN LEP INS IL6 HCRT
8 advanced sleep phase syndrome 32.1 PER3 PER2 HCRTR2 HCRT CRY1 CLOCK
9 recurrent hypersomnia 32.1 HLA-DQB1 HCRTR2 HCRT
10 narcolepsy 32.0 TNF SLC6A3 MOG LEP IL6 HLA-DQB1
11 restless legs syndrome 31.3 SNCA SLC6A3 HCRT CLOCK
12 narcolepsy 2 31.2 HLA-DQB1 HCRT
13 apnea, obstructive sleep 31.1 TNF REN LEP INS IL6 HCRT
14 post-traumatic stress disorder 31.1 SLC6A3 IL6 HCRT CRP
15 kidney disease 31.1 TNF REN LEP INS IL6 GHRL
16 cerebral palsy 31.0 TNF LEP IL6 HLA-DQB1 CRP
17 stroke, ischemic 31.0 TNF REN INS IL6 CRP
18 prader-willi syndrome 30.9 TNF LEP INS IL6 HCRT GHRL
19 respiratory failure 30.8 TNF REN INS IL6 CRP
20 pre-eclampsia 30.8 TNF REN LEP INS IL6 CRP
21 disease of mental health 30.8 TNF SNCA SLC6A3 LEP INS IL6
22 chronic fatigue syndrome 30.8 TNF INS IL6 CRP
23 prediabetes syndrome 30.7 LEP INS GHRL CRP
24 spondyloarthropathy 1 30.7 TNF IL6 CRP
25 long covid 30.7 TNF REN IL6 CRP
26 vascular dementia 30.7 TNF SNCA INS IL6
27 cardiovascular system disease 30.7 TNF REN LEP INS IL6 GHRL
28 deficiency anemia 30.7 TNF REN LEP INS IL6 GHRL
29 autoimmune disease 30.7 TNF MOG INS IL6 HLA-DQB1 CRP
30 fibromyalgia 30.7 TNF LEP INS IL6 CRP
31 central sleep apnea 30.7 REN LEP HCRT CRP
32 attention deficit-hyperactivity disorder 30.6 TNF SNCA SLC6A3 PER2 LEP INS
33 gout 30.6 TNF INS IL6 CRP
34 eating disorder 30.6 SLC6A3 LEP INS HCRTR1 HCRT GHRL
35 polycystic ovary syndrome 30.6 LEP INS GHRL CRP
36 anxiety 30.6 TNF SNCA SLC6A3 LEP INS IL6
37 eclampsia 30.6 TNF REN IL6
38 nutritional deficiency disease 30.6 LEP IL6 GHRL CRP
39 neurotic disorder 30.6 TNF INS IL6 CRP
40 transient cerebral ischemia 30.6 REN INS IL6 CRP
41 abdominal obesity-metabolic syndrome 1 30.6 LEP INS GHRL
42 gestational diabetes 30.6 TNF LEP INS IL6 GHRL CRP
43 adult syndrome 30.6 TNF REN LEP INS IL6 CRP
44 vascular disease 30.5 TNF LEP INS IL6 CRP
45 optic nerve disease 30.5 TNF MOG INS IL6 CRP
46 amyotrophic lateral sclerosis 1 30.5 TNF SNCA SLC6A3 MOG INS IL6
47 autism 30.5 TNF SNCA SLC6A3 PER2 LEP IL6
48 mood disorder 30.5 SLC6A3 PER3 IL6 HCRT CLOCK ANK3
49 autism spectrum disorder 30.5 TNF SNCA SLC6A3 PER2 LEP IL6
50 mild cognitive impairment 30.5 SNCA SLC6A3 INS IL6

Graphical network of the top 20 diseases related to Sleep Disorder:



Diseases related to Sleep Disorder

Symptoms & Phenotypes for Sleep Disorder

UMLS symptoms related to Sleep Disorder:


tremor; fever; back pain; dyspnea; vertigo; cachexia; headache; syncope; cyanosis; edema; pain; chronic pain; sciatica; snoring; sleep disturbances; icterus; seizures; signs and symptoms; signs and symptoms, digestive; hot flushes; vertigo/dizziness; sleeplessness; nervousness; psychiatric symptom; sluggishness; nightmares; hallucinations, hypnagogic

GenomeRNAi Phenotypes related to Sleep Disorder according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.15 ANK3 BMAL1 CLOCK CRP CRY1 GHRL
2 no effect GR00402-S-2 10.15 ANK3 CLOCK CRP GHRL HCRTR1 HCRTR2

MGI Mouse Phenotypes related to Sleep Disorder:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.51 ANK3 BMAL1 CLOCK CRY1 HCRT HCRTR1
2 homeostasis/metabolism MP:0005376 10.37 BMAL1 CLOCK CRP CRY1 GHRL HCRT
3 growth/size/body region MP:0005378 10.32 BMAL1 CLOCK CRY1 HCRT HLA-DQB1 IL6
4 muscle MP:0005369 10.31 BMAL1 CRY1 HCRT HCRTR2 HLA-DQB1 IL6
5 behavior/neurological MP:0005386 10.3 ANK3 BMAL1 CLOCK CRY1 GHRL HCRT
6 endocrine/exocrine gland MP:0005379 10.23 BMAL1 CLOCK CRY1 GHRL HLA-DQB1 IL6
7 cardiovascular system MP:0005385 10.21 BMAL1 CLOCK CRP CRY1 HCRT HLA-DQB1
8 renal/urinary system MP:0005367 10.2 ANK3 BMAL1 HLA-DQB1 IL6 INS LEP
9 cellular MP:0005384 10.18 BMAL1 CLOCK CRY1 HLA-DQB1 IL6 INS
10 liver/biliary system MP:0005370 10.13 BMAL1 CLOCK HLA-DQB1 IL6 INS LEP
11 adipose tissue MP:0005375 10.11 BMAL1 CLOCK CRY1 GHRL IL6 INS
12 digestive/alimentary MP:0005381 10.09 CLOCK GHRL HLA-DQB1 IL6 INS LEP
13 immune system MP:0005387 10.03 BMAL1 CRP CRY1 HLA-DQB1 IL6 INS
14 reproductive system MP:0005389 9.93 BMAL1 CLOCK CRY1 HLA-DQB1 IL6 INS
15 hematopoietic system MP:0005397 9.73 BMAL1 CRY1 HLA-DQB1 IL6 INS LEP
16 integument MP:0010771 9.32 BMAL1 CLOCK CRY1 IL6 INS LEP

Drugs & Therapeutics for Sleep Disorder

Drugs for Sleep Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 265)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tramadol Approved, Investigational Phase 4 27203-92-5 33741 5523
2
Ketamine Approved, Vet_approved Phase 4 6740-88-1, 1867-66-9 3821
3
Zolpidem Approved Phase 4 82626-48-0 5732
4
Rabeprazole Approved, Investigational Phase 4 117976-89-3, 117976-90-6 5029
5
Bupropion Approved Phase 4 31677-93-7, 34841-39-9, 34911-55-2 444
6
Norepinephrine Approved Phase 4 51-41-2 439260
7
Citalopram Approved Phase 4 59729-32-7, 59729-33-8 2771
8
Cobicistat Approved Phase 4 1004316-88-4 24950485 25151504
9
Elvitegravir Approved Phase 4 697761-98-1 23083982 5277135
10
Racivir Approved, Investigational Phase 4 143491-57-0, 143491-54-7 60877
11
Milnacipran Approved, Investigational Phase 4 92623-85-3, 96847-54-0 11622909 65833 6917779
12
Losartan Approved Phase 4 114798-26-4 3961
13
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198
14
Levodopa Approved Phase 4 59-92-7, 63-84-3 6047
15
Opicapone Approved, Investigational Phase 4 923287-50-7 135565903
16
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
17
Lemborexant Approved, Investigational Phase 4 1369764-02-2 76469283 56944144
18
Morphine Approved, Investigational Phase 4 57-27-2 5288826
19
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
20
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
21
Promethazine Approved, Investigational Phase 4 60-87-7 4927
22
Apomorphine Approved, Investigational Phase 4 41372-20-7, 58-00-4 6005
23
Suvorexant Approved, Investigational Phase 4 1030377-33-3 57505028 24965990
24
Iron Approved Phase 4 7439-89-6 29936
25
Dexmedetomidine Approved, Experimental, Vet_approved Phase 4 86347-14-0, 113775-47-6 68602 5311068
26
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
27
Mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7 4240 441336
28
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
29
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
30
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
31
Dexetimide Withdrawn Phase 4 21888-98-2 30843
32
Tenofovir Experimental, Investigational Phase 4 147127-20-6, 202138-50-9 464205 6398764
33
1,2-Dihydroxybenzene Experimental Phase 4 120-80-9 289
34 S 20098 Phase 4
35 Excitatory Amino Acid Antagonists Phase 4
36 Anesthetics, Dissociative Phase 4
37 Anti-Ulcer Agents Phase 4
38 Antacids Phase 4
39 Proton Pump Inhibitors Phase 4
40 GABA Agonists Phase 4
41 Antiviral Agents Phase 4
42 Nicotinic Agonists Phase 4
43 Cholinergic Agents Phase 4
44 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
45 Anti-Retroviral Agents Phase 4
46 Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
47 Anti-HIV Agents Phase 4
48 Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
49 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
50 Coagulants Phase 4

Interventional clinical trials:

(show top 50) (show all 552)
# Name Status NCT ID Phase Drugs
1 A Multicenter, Randomized, Double-blind, Placebo-controlled Study: Evaluation of the Efficacy and Safety of Agomelatine in the Treatment of Sleep Disorders and Depression in Patients With Parkinson's Disease Unknown status NCT03977441 Phase 4 Agomelatine or PIacebo
2 Sleep Disturbances in Hospitalized Children Unknown status NCT00749814 Phase 4
3 Are Patients Suffering From DSPS Show Compromising in Everyday Functions and Abilities (Attention and Concentration, Mood and Fatigue) Before Handling the Disorder? And Whether the Treatment Fixes the Disorder? Unknown status NCT02962037 Phase 4
4 Comparison of Effect of Peritonsillar Infiltration of Ketamine and Tramadol on Pediatric Posttonsillectomy Pain: A Double-blinded Randomized Placebo-controlled Clinical Trial Unknown status NCT03067103 Phase 4 Tramadol;Ketamine;Placebos
5 The Impact of Gastroesophageal Reflux Disease in Sleep Disorders: A Pilot Investigation of Rabeprazole, 20 mg Twice Daily for the Relief of GERD-Related Insomnia. Completed NCT00287391 Phase 4 Rabeprazole
6 A Randomized Placebo-controlled Trial Evaluating the Effect of Melatonin on Sleep Quality in Patients With Dementia Completed NCT03066518 Phase 4 Melatonin 5 mg
7 Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome With Major Depressive Disorder or Dysthymic Disorder Completed NCT00518986 Phase 4 armodafinil;placebo
8 Effect of Zolpidem vs Placebo on Insomnia and Daytime Function in Patients With Insomnia Associated With Osteoarthritis Completed NCT00530556 Phase 4 zolpidem
9 Impact of Low-Dose Dexmedetomidine on Sleep Quality in Mechanical Ventilation Patients After Surgery in Intensive Care Unit: a Pilot Randomized, Double-Blind, Placebo-Controlled Trial Completed NCT03335527 Phase 4 Dexmedetomidine;Placebo (normal saline)
10 Melatonin Replacement for Treatment of Sleep Disruption Completed NCT00507546 Phase 4 Ramelteon;Placebo
11 Impact of Smoking Cessation on Sleep Completed NCT00132821 Phase 4 Bupropion;Transdermal Nicotine Patch;Placebo Bupropion;Placebo transdermal nicotine patch
12 Psychobiology and Treatment Response in Primary Insomnia Completed NCT00177216 Phase 4 Zolpidem;Escitalopram;Placebo
13 Efficacy and Safety Assessment of ZOlpidem (Stilnox CR) Administered on as Needed Basis in Patients With Chronic insomNIA Completed NCT01024192 Phase 4 ZOLPIDEM SL800750
14 Switching From Atripla to Stribild Leads to Improvements in Central Nervous System Side Effects and Sleep Disturbances Completed NCT02477527 Phase 4 Stribild
15 National, Multicenter, Open Label, Phase IV, Before-after Design Study, in Adult Patients With Primary Insomnia to Evaluate Sleep Satisfaction and Psychomotor Performance After 1 Month of Treatment With Zolpidem CR (Ambien®CR) in 6 Sites in Argentina Completed NCT01097382 Phase 4 ZOLPIDEM
16 An Open Assessment of the Effect of Low-Dose Totelle® 1 mg on Menopausal Symptoms, Sexual Function and Quality of Life Completed NCT00195520 Phase 4 Totelle®
17 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed NCT01234675 Phase 4 Milnacipran;Placebo
18 A Single Dose, Open-Label, Randomized Two-Period Crossover Study in Healthy Young Subjects to Assess the Absolute Bioavailability of Tasimelteon (HETLIOZ™) Completed NCT02130999 Phase 4 tasimelteon 20 mg capsule;tasimelteon 2 mg I.V.
19 Delayed Sleep Phase Syndrome in Adolescents and Young Adults. Sleep, Personality, Developmental History, Circadian Rhythm, Daytime Functioning and Treatment Completed NCT00834886 Phase 4
20 Examination of the Effectiveness of Suvorexant in Improving Daytime Sleep in Shift Workers Completed NCT02491788 Phase 4 Suvorexant;Placebo
21 Assessments in Stress and Quality of Sleep/Life in Night-shift Nurses and Doctors Completed NCT02541747 Phase 4
22 Eszopiclone and Inflammatory Mediators in Patients With Acute Coronary Syndrome Completed NCT00822679 Phase 4 Eszopiclone
23 Effect of Angiotensin Receptor Blockers on Periodic Breathing During Sleep in Hypoxia Completed NCT03335904 Phase 4 Losartan;Placebo
24 A Double-Blind Placebo-Controlled, Randomized, Parallel-Group, Single-Site Study of Mometasone Furoate Nasal Spray (MFNS) In Subjects With Sleep-disordered Breathing Associated With Perennial Allergic Rhinitis (PAR) Using Home-Monitored Cardio-Respiratory Methodology. Completed NCT00359216 Phase 4 Mometasone furoate nasal spray;Placebo
25 SERVE-HF: Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation Completed NCT01164592 Phase 4
26 Open-label, Single-arm, Pilot Study to Evaluate the Effect of Opicapone 50 mg on Parkinson's Disease Patients With End-of-dose Motor Fluctuations and Associated Sleep Disorders Recruiting NCT04986995 Phase 4 Opicapone
27 The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Interventional) Recruiting NCT05247125 Phase 4 Melatonin treatment
28 Lemborexant in Delayed Sleep Phase Syndrome Recruiting NCT05463861 Phase 4 Lemborexant;Placebo
29 Yangzheng Compound Mixture in the Treatment of Sleep Disorder in Cancer Patients With Qi-Yin Deficiency Syndrome During Chemotherapy: a Multicenter, Randomized, Prospective, Real-world Study Recruiting NCT04641819 Phase 4 Yangzheng Compound Mixture
30 Melatonin - Production and Release in Children and Adolescents With ADHD and Chronic Sleep Problems and Effects of Melatonin on Sleep Recruiting NCT04318067 Phase 4 Melatonin 3 mg
31 Fremanezumab, Migraine and Sleep Recruiting NCT04693533 Phase 4 Fremanezumab Prefilled Syringe [Ajovy]
32 Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia: A Randomized Placebo-Controlled Crossover Trial Recruiting NCT04706091 Phase 4 Suvorexant
33 Opioid-Free Versus Transitional Anesthetic With Opioids From Tonsillectomy Recruiting NCT04528173 Phase 4 Ketorolac;Dexmedetomidine;Morphine;Fentanyl
34 Double Bind Randomized Placebo-controlled Cross-over Study to Evaluate Effect of Continuous Apomorphine During the Night on Sleep Disorders in Insomniac Patients With Parkinson's Disease Active, not recruiting NCT02940912 Phase 4 Apomorphine;Placebo
35 Effect of Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes: A Randomized 3-month Clinical Trial Using a Sequential Parallel Comparison Design Active, not recruiting NCT03818581 Phase 4 Suvorexant
36 Optimum Frequency and Timing of Oral Iron Administration for Childhood Restless Leg Syndrome/Periodic Limb Movement Disorder Enrolling by invitation NCT04610827 Phase 4 Ferrous sulfate
37 Effect of Propofol on Postoperative Sleep Quality in Elderly Patients With Sleep Disorders: a Multicentre, Randomized, Controlled Clinical Study Not yet recruiting NCT05325762 Phase 4 Propofol;Dexmedetomidine;Saline
38 Efficacy of Intranasal Steroid for Children With Sleep-Disordered Breathing Non-Responsive to Initial Treatment With Intranasal Saline: A Randomized Trial Not yet recruiting NCT05382494 Phase 4 Mometasone Furoate 50mcg Nasal Spray;Sodium Chloride 0.9 % Nasal Spray
39 Effect of Guanfacine Extended-Release on Attention Deficit Hyperactivity Disorder (ADHD)-Associated Insomnia Terminated NCT01156051 Phase 4 Guanfacine extended-release tablets;Placebo comparator
40 Controlled-Release Melatonin (Melatonin CR)for the Treatment of Impaired Sleep Maintenance (ISM) in 4-8 Year Old Children With Autism Spectrum Disorders (ASD). Terminated NCT01033565 Phase 4 Natrol
41 Stabilisation de la qualité du Sommeil Chez le Sujet en Douleurs Orofaciales Chroniques - étude expérimentale en chassé croisé : Trazodone/ Placebo Terminated NCT03522207 Phase 4 Trazodone;Placebos;placebos
42 A Randomized, Prospective, Double Blind, Placebo-Controlled Trial of Two Different Doses of Oral Melatonin Supplements in Chronic Kidney Disease (CKD)-Associated Sleep Disorders Unknown status NCT01922999 Phase 2, Phase 3 Melatonin
43 Mirtazapine for the Treatment of Sleep Disorders in Alzheimer's Disease: a Randomized, Double-blind, Placebo-controlled Study Unknown status NCT01867775 Phase 3 Mirtazapine
44 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
45 Effects of Cognitive-Behavioral Therapy on Sleep Disturbance in Peritoneal Dialysis Patients Unknown status NCT00155441 Phase 3
46 Open-Label Safety Study of a 1-Year 20 mg Dose Regimen of Tasimelteon for Treatment of Non-24-Hour-Sleep-Wake Disorder (N24HSWD) in Blind Individuals With No Light Perception Unknown status NCT01218789 Phase 3 tasimelteon
47 Phase II/III Clinical Trial of NPC-15 - Verification of the Efficacy for Sleep Disorders of Children With Autism Spectrum Disorders - Completed NCT02757066 Phase 2, Phase 3 NPC-15 Granules Lower Dose;NPC-15 Granules Higher Dose;NPC-15 Placebo Granule
48 Z-Drugs for the Treatment of Sleep Disorders in Alzheimer's Disease: a Randomized, Triple-blind, Placebo-controlled Study Completed NCT03075241 Phase 3 Zolpidem;Zoplicone;Placebo
49 Phase III Clinical Trial of NPC-15 - Study of the Efficacy and Safety for Sleep Disorders of Children With Neurodevelopmental Disorders - Completed NCT02757079 Phase 3 NPC-15
50 A Phase 3, Randomized, Open-Label, Two-Arm, Parallel-Group, Multicenter, Multinational Trial to Compare the Efficacy of Rotigotine Transdermal Patch to That of Ropinirole on Early Morning Motor Impairment and Sleep Disorders in Subjects With Early-Stage, Idiopathic Parkinson's Disease Completed NCT00243971 Phase 3 SPM 962

Search NIH Clinical Center for Sleep Disorder

Inferred drug relations via UMLS 71 / NDF-RT 50 :


zolpidem
Zolpidem tartrate

Genetic Tests for Sleep Disorder

Anatomical Context for Sleep Disorder

Organs/tissues related to Sleep Disorder:

MalaCards : Heart, Brain, Lung, Eye, Breast, Spinal Cord, Kidney

Publications for Sleep Disorder

Articles related to Sleep Disorder:

(show top 50) (show all 16749)
# Title Authors PMID Year
1
Sleep and health-related quality of life in women following a cancer diagnosis: results from the Women's Wellness after Cancer Program in Australia. 41
36350379 2022
2
Effect of Intraoperative Esketamine Infusion on Postoperative Sleep Disturbance After Gynecological Laparoscopy: A Randomized Clinical Trial. 41
36454569 2022
3
The Effects of Cognitive Behavioral Therapy for Insomnia among College Students with Irritable Bowel Syndrome: A Randomized Controlled Trial. 41
36361052 2022
4
Agomelatine: a potential novel approach for the treatment of memory disorder in neurodegenerative disease. 62
36204828 2023
5
Discrimination and insomnia: Examining depressive symptoms and nicotine withdrawal through a serial mediation model in a sample of smokers. 62
36244244 2023
6
Lavender essential oil fractions alleviate sleep disorders induced by the combination of anxiety and caffeine in mice. 62
36309115 2023
7
Tinnitus and risk of attempted suicide: A one year follow-up study. 62
36372122 2023
8
Occurrence of Z-drugs, benzodiazepines, and ketamine in wastewater in the United States and Mexico during the Covid-19 pandemic. 62
36243065 2023
9
Prevalence and associated factors of poor sleep quality among Chinese retirees: A multicenter cross-sectional study. 62
36179777 2023
10
Interactions between heavy metals and sleep duration among pre-and postmenopausal women: A current approach to molecular mechanisms involved. 62
36347409 2023
11
Microglial homeostasis disruption modulates non-rapid eye movement sleep duration and neuronal activity in adult female mice. 62
36202169 2023
12
Network pharmacology and pharmacological evaluation for deciphering novel indication of Sishen Wan in insomnia treatment. 62
36288650 2023
13
The prevalence and risk factors of mental problems in medical students during COVID-19 pandemic: A systematic review and meta-analysis. 62
36341802 2023
14
Evaluation of the Regulatory Role of Circadian Rhythm Related Long Non-Coding RNAs in ADHD Etiogenesis. 62
36254757 2023
15
Risk factors for Meniere disease: a systematic review and meta-analysis. 62
35794275 2022
16
Clinical features of definite vestibular migraine through the lens of central sensitization: a cross-sectional study. 62
34370217 2022
17
Prospective evaluation of sleep disturbances in chronic pancreatitis and its impact on quality of life: a pilot study. 62
34981297 2022
18
Clinical and polysomnographic features of trauma associated sleep disorder. 62
35962771 2022
19
Cardiovascular diseases and sleep disorders in South Asians: A scoping review. 62
36054942 2022
20
Sleep disorders and polysomnography findings in patients with autoimmune encephalitis. 62
36454441 2022
21
Sleep-related hypoventilation and hypercapnia in multiple system atrophy detected by polysomnography with transcutaneous carbon dioxide monitoring. 62
35025012 2022
22
Brachycephalic obstructive airway syndrome: much more than a surgical problem. 62
36342210 2022
23
Total esophagogastric dissociation (TEGD) in neurologically impaired children: the floor to parents. 62
36129620 2022
24
Sex-specific incidences and risk profiles of suicide mortality in people with alcohol dependence in Taiwan. 62
35913020 2022
25
The lncRNA MRPL20-AS1 is associated with severe OSAS and downregulated upon hypoxic injury of endothelial cells. 62
35988669 2022
26
Inflammation markers in moderate and severe obstructive sleep apnea: the influence of sex. 62
34988848 2022
27
Prevalence of obstructive sleep apnea as assessed by polysomnography in psychiatric patients with sleep-related problems. 62
35029795 2022
28
Oxygen saturation as a predictor of inflammation in obstructive sleep apnea. 62
34792741 2022
29
Cognitive Complaints and Comorbidities in Obstructive Sleep Apnea. 62
36333083 2022
30
The Relationship Between Epilepsy, Obstructive Sleep Apnea, and Treatment Outcome. 62
36333082 2022
31
Patient preferences in obstructive sleep apnea-a discrete choice experiment. 62
35001351 2022
32
Combination of atomoxetine with the novel antimuscarinic aroxybutynin improves mild to moderate OSA. 62
35975547 2022
33
Spinal cord injury-induced cognitive impairment: a narrative review. 62
35662196 2022
34
Association between clinical outcomes and restless legs syndrome in Japanese patients with ulcerative colitis. 62
35852410 2022
35
Sex Differences in Mental Health Problems and Psychiatric Hospitalization in Autistic Young Adults. 62
36287538 2022
36
Role of Oxidative Stress and Inflammation in Insomnia Sleep Disorder and Cardiovascular Diseases: Herbal Antioxidants and Anti-inflammatory Coupled with Insomnia Detection Using Machine Learning. 62
36464881 2022
37
Associations between age-related macular degeneration and sleep dysfunction: A systematic review. 62
36054031 2022
38
Use of Benzodiazepines and Z-Drugs in Inflammatory Bowel Disease. 62
36288107 2022
39
Possible association between vitamin B12 deficiency and restless legs syndrome. 62
36401952 2022
40
Prevalence of sleep disorders in a large French cohort of aircrew members and risk of in-flight sleepiness. 62
36087520 2022
41
Supine sleep patterns as a part of phenotyping patients with sleep apnea-a pilot study. 62
35020131 2022
42
Sleep disorders are associated with testosterone deficiency and erectile dysfunction-a U.S. claims database analysis. 62
36473958 2022
43
The association between sleep deprivation and arterial pressure variations: a systematic literature review. 62
35169694 2022
44
Neuropsychiatric symptoms in post-COVID-19 long haulers. 62
35543105 2022
45
Epileptic seizures in patients with anti-IgLON5 disease. 62
36395637 2022
46
Prevalence of late and long-term effects of cancer (treatment) and use of complementary and alternative medicine in Norway. 62
36471296 2022
47
Psychiatric symptoms and emotional impact of the COVID-19 pandemic on Italian adolescents during the third lockdown: a cross-sectional cohort study. 62
36463342 2022
48
Prospective association of short sleep duration in newborns with bruxism behavior in children: The Japan Environment and Children's Study (JECS). 62
36029753 2022
49
Effects of anti-seizure therapies on sleep in patients with epilepsy: A literature review. 62
36071677 2022
50
Listening to COVID-19 survivors: what they need after early discharge from hospital - a qualitative study. 62
35080475 2022

Variations for Sleep Disorder

Expression for Sleep Disorder

Search GEO for disease gene expression data for Sleep Disorder.

Pathways for Sleep Disorder

Pathways related to Sleep Disorder according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 TNF LEP INS IL6 HLA-DQB1
2
Show member pathways
12.06 REN LEP INS GHRL
3
Show member pathways
12.01 PER3 PER2 CRY1 CLOCK BMAL1
4 11.93 TNF LEP INS IL6
5 11.57 TNF IL6 CRP
6 11.54 IL6 CRY1 CLOCK BMAL1
7 11.3 PER2 CRY1 CLOCK BMAL1
8 11.26 LEP IL6 CRY1 CLOCK BMAL1
9 11.22 TNF LEP INS IL6
10
Show member pathways
11.15 CRY1 CLOCK BMAL1
11 11 TNF LEP IL6
12 10.93 LEP INS GHRL
13 10.89 CRP IL6 TNF
14 10.6 HCRTR2 HCRTR1
15 10.51 PER3 PER2 CRY1 CLOCK BMAL1
16
Show member pathways
10.24 TNF IL6
17 10.23 HCRTR2 HCRTR1 HCRT

GO Terms for Sleep Disorder

Cellular components related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CLOCK-BMAL transcription complex GO:1990513 8.92 CLOCK BMAL1

Biological processes related to Sleep Disorder according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 10.16 TNF LEP INS IL6 GHRL
2 glucose homeostasis GO:0042593 10.14 LEP INS IL6 CRY1
3 positive regulation of cold-induced thermogenesis GO:0120162 10.1 PER2 LEP HCRT GHRL
4 acute-phase response GO:0006953 10.03 INS IL6 CRP
5 glucose metabolic process GO:0006006 10.03 GHRL INS LEP TNF
6 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.02 TNF LEP IL6
7 response to activity GO:0014823 10.01 TNF LEP IL6 CRY1
8 circadian regulation of gene expression GO:0032922 9.96 PER3 PER2 CRY1 CLOCK BMAL1
9 entrainment of circadian clock by photoperiod GO:0043153 9.95 PER3 PER2 CRY1
10 feeding behavior GO:0007631 9.91 HCRT HCRTR1 HCRTR2
11 dopamine uptake involved in synaptic transmission GO:0051583 9.88 SNCA SLC6A3
12 regulation of hair cycle GO:0042634 9.87 CLOCK BMAL1
13 regulation of type B pancreatic cell development GO:2000074 9.83 CLOCK BMAL1
14 negative regulation of glucocorticoid receptor signaling pathway GO:2000323 9.8 CRY1 CLOCK BMAL1
15 rhythmic process GO:0048511 9.77 PER3 PER2 CRY1 CLOCK BMAL1
16 negative regulation of lipid storage GO:0010888 9.76 CRP IL6 LEP TNF
17 regulation of insulin secretion GO:0050796 9.73 TNF PER2 LEP IL6 CLOCK BMAL1
18 circadian rhythm GO:0007623 9.44 TNF PER3 PER2 LEP CRY1 CLOCK

Molecular functions related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription cis-regulatory region binding GO:0000976 9.85 TNF SNCA PER3 PER2 BMAL1
2 signaling receptor binding GO:0005102 9.61 TNF SLC6A3 REN MOG LEP IL6
3 orexin receptor activity GO:0016499 8.92 HCRTR2 HCRTR1

Sources for Sleep Disorder

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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