MCID: SLP005
MIFTS: 58

Sleep Disorder

Categories: Mental diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Sleep Disorder

MalaCards integrated aliases for Sleep Disorder:

Name: Sleep Disorder 12 15 17
Sleep Disorders 43 15 72 33
Non-Organic Sleep Disorder 12 72

Classifications:



External Ids:

Disease Ontology 12 DOID:535
ICD9CM 35 307.4
UMLS 72 C0154564 C0154565 C0851578

Summaries for Sleep Disorder

MedlinePlus : 43 What is sleep? Sleep is a complex biological process. While you are sleeping, you are unconscious, but your brain and body functions are still active. They are doing a number of important jobs that help you stay healthy and function at your best. So when you don't get enough quality sleep, it does more than just make you feel tired. It can affect your physical and mental health, thinking, and daily functioning. What are sleep disorders? Sleep disorders are conditions that disturb your normal sleep patterns. There are more than 80 different sleep disorders. Some major types include Insomnia - being unable to fall asleep and stay asleep. This is the most common sleep disorder. Sleep apnea - a breathing disorder in which you stop breathing for 10 seconds or more during sleep Restless leg syndrome (RLS) - a tingling or prickly sensation in your legs, along with a powerful urge to move them Hypersomnia - being unable to stay awake during the day. This includes narcolepsy, which causes extreme daytime sleepiness. Circadian rhythm disorders - problems with the sleep-wake cycle. They make you unable to sleep and wake at the right times. Parasomnia - acting in unusual ways while falling asleep, sleeping, or waking from sleep, such as walking, talking, or eating Some people who feel tired during the day have a true sleep disorder. But for others, the real problem is not allowing enough time for sleep. It's important to get enough sleep every night. The amount of sleep you need depends on several factors, including your age, lifestyle, health, and whether you have been getting enough sleep recently. Most adults need about 7-8 hours each night. What causes sleep disorders? There are different causes for different sleep disorders, including Other conditions, such as heart disease, lung disease, nerve disorders, and pain Mental illnesses, including depression and anxiety Medicines Genetics Sometimes the cause is not known. There are also some factors that can contribute to sleep problems, including Caffeine and alcohol An irregular schedule, such as working the night shift Aging. As people age, they often get less sleep or spend less time in the deep, restful stage of sleep. They are also more easily awakened. What are the symptoms of sleep disorders? The symptoms of sleep disorders depend on the specific disorder. Some signs that you may have a sleep disorder include that You regularly take more than 30 minutes each night to fall asleep You regularly wake up several times each night and then have trouble falling back to sleep, or you wake up too early in the morning You often feel sleepy during the day, take frequent naps, or fall asleep at the wrong times during the day Your bed partner says that when you sleep, you snore loudly, snort, gasp, make choking sounds, or stop breathing for short periods You have creeping, tingling, or crawling feelings in your legs or arms that are relieved by moving or massaging them, especially in the evening and when trying to fall asleep Your bed partner notices that your legs or arms jerk often during sleep You have vivid, dreamlike experiences while falling asleep or dozing You have episodes of sudden muscle weakness when you are angry or fearful, or when you laugh You feel as though you cannot move when you first wake up How are sleep disorders diagnosed? To make a diagnosis, your health care provider will use your medical history, your sleep history, and a physical exam. You may also have a sleep study (polysomnogram). The most common types of sleep studies monitor and record data about your body during a full night of sleep. The data includes Brain wave changes Eye movements Breathing rate Blood pressure Heart rate and electrical activity of the heart and other muscles Other types of sleep studies may check how quickly you fall asleep during daytime naps or whether you are able to stay awake and alert during the day. What are the treatments for sleep disorders? Treatments for sleep disorders depend on which disorder you have. They may include Good sleep habits and other lifestyle changes, such as a healthy diet and exercise Cognitive behavioral therapy or relaxation techniques to reduce anxiety about getting enough sleep CPAP (continuous positive airway pressure) machine for sleep apnea Bright light therapy (in the morning) Medicines, including sleeping pills. Usually, providers recommend that you use sleeping pills for a short period of time. Natural products, such as melatonin. These products may help some people, but are generally for short-term use. Make sure to check with your health care provider before you take any of them.

MalaCards based summary : Sleep Disorder, also known as sleep disorders, is related to advanced sleep phase syndrome and sleep apnea, and has symptoms including seizures, tremor and fever. An important gene associated with Sleep Disorder is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are Peptide ligand-binding receptors and Circadian rythm related genes. The drugs Naltrexone and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and eye, and related phenotypes are behavior/neurological and cardiovascular system

Disease Ontology : 12 A disease of mental health that involves disruption of sleep patterns.

Wikipedia : 75 A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal. Some... more...

Related Diseases for Sleep Disorder

Diseases in the Sleep Disorder family:

Rare Sleep Disorder

Diseases related to Sleep Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 677)
# Related Disease Score Top Affiliating Genes
1 advanced sleep phase syndrome 33.4 PER3 PER2 HCRT
2 sleep apnea 33.3 LEP HCRT CRP
3 narcolepsy 1 33.2 MOG HCRT
4 delayed sleep phase disorder 33.1 PER3 PER2 CRY1
5 narcolepsy 32.4 MOG LEP HCRTR2 HCRTR1 HCRT
6 migraine with or without aura 1 32.0 NPS HRH3 HCRT
7 cluster headache 30.3 PRL HCRTR2
8 disease of mental health 30.2 NPS MAPT HCRT
9 apnea, obstructive sleep 30.2 MMD LEP HCRT FXYD1 CRP ARIH1
10 rohhad 30.0 HCRTR2 HCRTR1 HCRT
11 inherited metabolic disorder 29.8 MMD LEP CRP
12 rare sleep disorder 12.2
13 non 24 hour sleep wake disorder 12.1
14 idiopathic hypersomnia 11.6
15 advanced sleep phase syndrome, familial, 1 11.5
16 kleine-levin hibernation syndrome 11.5
17 rem sleep behavior disorder 11.5
18 periodic limb movement disorder 11.4
19 hypersomnia 11.4
20 machado-joseph disease 11.4
21 short sleeper 11.4
22 bruxism 11.3
23 obesity-hypoventilation syndrome 11.3
24 recurrent hypersomnia 11.3
25 creutzfeldt-jakob disease 11.2
26 tuberous sclerosis 1 11.2
27 dementia, lewy body 11.2
28 narcolepsy 7 11.2
29 neurodevelopmental disorder with severe motor impairment and absent language 11.0
30 progeroid short stature with pigmented nevi 10.9
31 brunner syndrome 10.9
32 chromosome 1q21.1 deletion syndrome, 1.35-mb 10.9
33 mental retardation, autosomal recessive 37 10.9
34 lyme disease - neurological complications 10.9
35 central hypoventilation syndrome, congenital 10.8
36 restless legs syndrome 10.8
37 central sleep apnea 10.7
38 congestive heart failure 10.6
39 narcolepsy 2 10.6
40 heart disease 10.6
41 cerebrovascular disease 10.5
42 attention deficit-hyperactivity disorder 10.5
43 body mass index quantitative trait locus 1 10.5
44 stroke, ischemic 10.4
45 anxiety 10.4
46 movement disease 10.4
47 kidney disease 10.4
48 depression 10.4
49 down syndrome 10.4
50 chronic pain 10.4

Graphical network of the top 20 diseases related to Sleep Disorder:



Diseases related to Sleep Disorder

Symptoms & Phenotypes for Sleep Disorder

UMLS symptoms related to Sleep Disorder:


seizures, tremor, fever, dyspnea, edema, cachexia, back pain, vertigo, pain, headache, syncope, cyanosis, chronic pain, snoring, sciatica, sleep disturbances, icterus, signs and symptoms, signs and symptoms, digestive, hot flushes, vertigo/dizziness, sleeplessness, nervousness, psychiatric symptom, sluggishness, nightmares, hallucinations, hypnagogic

MGI Mouse Phenotypes related to Sleep Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 ADORA1 ANK3 CRY1 HAPLN1 HCRT HCRTR1
2 cardiovascular system MP:0005385 9.81 ADORA1 CRP CRY1 FXYD1 HCRT HRH3
3 muscle MP:0005369 9.5 CRY1 FXYD1 HCRT HCRTR2 LEP MAPT
4 nervous system MP:0003631 9.44 ADORA1 ANK3 CRY1 HCRT HCRTR1 HCRTR2

Drugs & Therapeutics for Sleep Disorder

DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Amitriptyline This drug in indicated for the following conditions [FDA label]: Major depressive disorder in adults Management of neuropathic pain in adults Prophylactic treatment of chronic tension-type headache (CTTH) in adults Prophylactic treatment of migraine in adults Treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products. This product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis [FDA label] Off-label uses: irritable bowel syndrome, sleep disorders, diabetic neuropathy, agitation, fibromyalgia, and insomnia DB00321
2 Armodafinil Investigated for use/treatment in sleep disorders, obstructive sleep apnea, schizophrenia and schizoaffective disorders, depression, and bipolar disorders. DB06413
3 Mirtazapine This drug is indicated for the treatment of major depressive disorder and its associated symptoms.[FDA label] Mirtazapine has been used off-label for a variety of conditions including panic disorder, generalized anxiety disorder, dysthymia, tension headaches, hot flushes, post-traumatic stress disorder (PTSD), sleep disorders, substance abuse disorders, and sexual disorders, among others.[A177811,A177946] DB00370

Drugs for Sleep Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 471)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
2
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4
Doxepin Approved, Investigational Phase 4 1668-19-5 667477 667468
5
Rasagiline Approved Phase 4 136236-51-6 3052776
6
Ropinirole Approved, Investigational Phase 4 91374-21-9, 91374-20-8 5095 497540
7
Citalopram Approved Phase 4 59729-33-8 2771
8
Cobicistat Approved Phase 4 1004316-88-4
9
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
10
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
11
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
12
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
13
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
14
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
15
Morphine Approved, Investigational Phase 4 57-27-2 5288826
16
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
17
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
18
Cetirizine Approved Phase 4 83881-51-0 2678
19
Levocetirizine Approved Phase 4 130018-77-8 1549000
20
Haloperidol Approved Phase 4 52-86-8 3559
21
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
22
Lacosamide Approved Phase 4 175481-36-4, 860352-01-8 219078
23
Eplerenone Approved Phase 4 107724-20-9 150310 443872
24
Zolpidem Approved Phase 4 82626-48-0 5732
25
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
26
Ethanol Approved Phase 4 64-17-5 702
27
Estazolam Approved, Illicit Phase 4 29975-16-4 3261
28
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
29
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
30
Flunarizine Approved Phase 4 52468-60-7 941361
31
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
32
Pramipexole Approved, Investigational Phase 4 104632-26-0 59868 119570
33
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
34
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
35
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
36
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
37
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
38
tannic acid Approved Phase 4 1401-55-4
39
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
40
Apomorphine Approved, Investigational Phase 4 41372-20-7, 58-00-4 6005
41
Rotigotine Approved Phase 4 99755-59-6, 92206-54-7 57537
42
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
43
Sodium oxybate Approved Phase 4 502-85-2 5360545
44
Galantamine Approved Phase 4 357-70-0 9651
45
Ribavirin Approved Phase 4 36791-04-5 37542
46
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
47
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
48
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
49
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
50
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896

Interventional clinical trials:

(show top 50) (show all 910)
# Name Status NCT ID Phase Drugs
1 Are Patients Suffering From DSPS Show Compromising in Everyday Functions and Abilities (Attention and Concentration, Mood and Fatigue) Before Handling the Disorder? And Whether the Treatment Fixes the Disorder? Unknown status NCT02962037 Phase 4
2 Double Bind Randomized Placebo-controlled Cross-over Study to Evaluate Effect of Continuous Apomorphine During the Night on Sleep Disorders in Insomniac Patients With Parkinson's Disease Unknown status NCT02940912 Phase 4 Apomorphine;Placebo
3 Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder Unknown status NCT00442481 Phase 4 Escitalopram
4 A Comparison Between Two Different Oral Appliance Therapies: Somnodent vs Herbst Appliance in Patients With Mild and Moderate OSA Unknown status NCT02724865 Phase 4
5 Evaluation of Cholecalciferol Supplementation in Chronic Kidney Disease Patients With Restless Leg Syndrome Unknown status NCT03063190 Phase 4 Vitamin D;Placebo Oral Tablet
6 Sleep Disturbances in Hospitalized Children Unknown status NCT00749814 Phase 4
7 Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? A Randomized, Double-blinded, Placebo-controlled, Crossover Study. Unknown status NCT02806440 Phase 4 Low dose naltrexone;Placebo
8 Pilot Study: The Effect of Rozerem on Sleep Disturbance After Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
9 Comparison of Effect of Peritonsillar Infiltration of Ketamine and Tramadol on Pediatric Posttonsillectomy Pain: A Double-blinded Randomized Placebo-controlled Clinical Trial Unknown status NCT03067103 Phase 4 Tramadol;Ketamine;Placebos
10 Effects of Gabapentin Enacarbil on Intensity of Cortical Arousal, Heart Rate, Blood Pressure and Anterior Tibialis EMG Responses Associated With PLMs During Sleep in Patients With RLS Using a Novel Computer Assisted Scoring System Unknown status NCT02424695 Phase 4 Gabapentin Enacarbil (GEn);Placebo
11 Assessments in Stress and Quality of Sleep/Life in Night-shift Nurses and Doctors Completed NCT02541747 Phase 4
12 Delayed Sleep Phase Syndrome in Adolescents and Young Adults. Sleep, Personality, Developmental History, Circadian Rhythm, Daytime Functioning and Treatment Completed NCT00834886 Phase 4
13 Phase IV 4 Way Crossover Study to Assess and Compare the Effect of a Single Nighttime Administration of Zolpidem, Silenor and Placebo on Arousability, Ataxia/Balance and Cognitive Performance in Healthy Volunteers. Completed NCT02353299 Phase 4 Silenor 6 mg;zolpidem 10 mg;Placebo;Placebo
14 The Effect of Armodafinil (Nuvigil) on Fatigue and Quality of Life in Peri- and Postmenopausal Women Completed NCT01460628 Phase 4 Armodafinil
15 Effects of Rasagiline on Sleep Disturbances in PD: A Single Center, Randomized, Double-blind, Placebo run-in, Polysomnographic Clinical Phase IV Trial Completed NCT01442610 Phase 4 Rasagiline;Placebo
16 Effect of Zolpidem vs Placebo on Insomnia and Daytime Function in Patients With Insomnia Associated With Osteoarthritis Completed NCT00530556 Phase 4 zolpidem
17 An Open Assessment of the Effect of Low-Dose Totelle® 1 mg on Menopausal Symptoms, Sexual Function and Quality of Life Completed NCT00195520 Phase 4 Totelle®
18 Single Blind, Multi-center, Post Marketing Clinical Study of Zolpidem (Myslee) in Adolescent Patients With Insomnia - Evaluation With Polysomnography Completed NCT00653562 Phase 4 zolpidem
19 National, Multicenter, Open Label, Phase IV, Before-after Design Study, in Adult Patients With Primary Insomnia to Evaluate Sleep Satisfaction and Psychomotor Performance After 1 Month of Treatment With Zolpidem CR (Ambien®CR) in 6 Sites in Argentina Completed NCT01097382 Phase 4 ZOLPIDEM
20 Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in ICD Patients Completed NCT00708786 Phase 4
21 Efficacy and Safety Assessment of ZOlpidem (Stilnox CR) Administered on as Needed Basis in Patients With Chronic insomNIA Completed NCT01024192 Phase 4 ZOLPIDEM SL800750
22 Switching From Atripla to Stribild Leads to Improvements in Central Nervous System Side Effects and Sleep Disturbances Completed NCT02477527 Phase 4 Stribild
23 Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome With Major Depressive Disorder or Dysthymic Disorder Completed NCT00518986 Phase 4 armodafinil;placebo
24 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed NCT01234675 Phase 4 Milnacipran;Placebo
25 The Impact of Gastroesophageal Reflux Disease in Sleep Disorders: A Pilot Investigation of Rabeprazole, 20 mg Twice Daily for the Relief of GERD-Related Insomnia. Completed NCT00287391 Phase 4 Rabeprazole
26 Paroxetine in the Treatment of Chronic Primary Insomnia: A Double-Blind, Randomized, Placebo-Controlled Study of Efficacy Over Six Weeks Completed NCT00178048 Phase 4 paroxetine
27 Behavioral and Pharmacological Treatment for Insomnia Completed NCT00042146 Phase 4 zolpidem
28 Randomized, Double-Blinded Clinical Trial to Evaluate the Incidence and Severity of Neuropsychiatric Side Effects and Antiviral Efficacy of Efavirenz Given as a Stepped Dosage Over 2 Weeks Versus the Usual Dosage in HIV-Infected Patients. Completed NCT00556634 Phase 4 Efavirenz
29 An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue Completed NCT00678691 Phase 4 armodafinil;placebo
30 A Randomized Placebo-controlled Trial Evaluating the Effect of Melatonin on Sleep Quality in Patients With Dementia Completed NCT03066518 Phase 4 Melatonin 5 mg
31 Hydromorphone OROS in Korean Cancer Patients: Evaluation of Its Clinical Usefulness in Improvement of Sleep Disturbance Completed NCT00766831 Phase 4 Hydromorphone
32 Placebo Controlled Pilot Study on the Efficacy of Levocetirizine 5 mg in Reducing Symptoms, Airway Resistance, and Sleep Impairment in Patients With Persistent Allergic Rhinitis Completed NCT00355771 Phase 4 Levocetirizine;Placebo
33 Efficacy and Safety of Eszopiclone (Lunesta) in Nursing Home Patients Completed NCT00460993 Phase 4 Lunesta
34 A Phase IV 3-Way Double-blind, Randomized, Crossover Study to Compare the Awakening Threshold Effects (Responsivity) of Belsomra 10 mg and 20 mg to Placebo in Non-elderly Insomniacs Completed NCT03312517 Phase 4 Suvorexant 10 mg;Suvorexant 20 mg;Placebo oral capsule
35 A Single Dose, Open-Label, Randomized Two-Period Crossover Study in Healthy Young Subjects to Assess the Absolute Bioavailability of Tasimelteon (HETLIOZ™) Completed NCT02130999 Phase 4 tasimelteon 20 mg capsule;tasimelteon 2 mg I.V.
36 Cognitive-Behavior Therapy for Insomnia: Component Analysis and Treatment Completed NCT00869934 Phase 4
37 Phase 4 Study of the Effects of Modafinil on Waking Function and on Sleep in Individuals With Primary Insomnia Completed NCT00124384 Phase 4 modafinil
38 Experimental Study of Mobile Base Station Related Radio-Frequency Electromagnetic Radiation in Healthy Adults and Adolescents Completed NCT00138905 Phase 4
39 Progesterone Reduces Wakefulness in Sleep EEG and Has no Effect on Cognition in Healthy Postmenopausal Women Completed NCT00530582 Phase 4 progesterone
40 A Randomized, Double Blind, Study to Evaluate the Efficacy of Nasal Nicotine Spray to Reduce Post-Operative Opioid Requirements in Nonsmokers in Elective Laparoscopic Bariatric Surgical Patients Completed NCT01194089 Phase 4 Nasal Nicotine Spray;Nasal Normal Saline Spray
41 Eszopiclone and Inflammatory Mediators in Patients With Acute Coronary Syndrome Completed NCT00822679 Phase 4 Eszopiclone
42 Improving Sleep in Nursing Homes Completed NCT00576927 Phase 4 Ramelteon;Placebo
43 Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia Completed NCT03075657 Phase 4 Risperidone;Risperidone and Ramelteon;Haloperidol;Haloperidol and Ramelteon
44 Impact of Smoking Cessation on Sleep Completed NCT00132821 Phase 4 Bupropion;Transdermal Nicotine Patch;Placebo Bupropion;Placebo transdermal nicotine patch
45 Searching for "Sleep Friendly" Therapies for a Sleepy Population: A Double-Blind, Placebo-Controlled, Randomized Trial to Assess the Effects of Lacosamide on Sleep and Wake in Adults With Focal Epilepsy Completed NCT01190098 Phase 4 Lacosamide;Placebo
46 Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil Completed NCT01965925 Phase 4 Modafinil;Placebo
47 Sleep Apnea. Concordance Between Non-reference and Reference Centres Completed NCT00424658 Phase 4
48 Psychobiology and Treatment Response in Primary Insomnia Completed NCT00177216 Phase 4 Zolpidem;Escitalopram;Placebo
49 Randomized, Double-blind, Placebo-controlled Trial to Measure the Efficacy and Safety of Vitamin D3 in Patients With Fibromyalgia. Completed NCT03369379 Phase 4 D3 Vitamin
50 Effects of Eplerenone on Left Ventricular Hypertrophy in Patients With Resistant Hypertension and Obstructive Sleep Apnoea Completed NCT03186742 Phase 4 Eplerenone 50 mg Tab

Search NIH Clinical Center for Sleep Disorder

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Amitriptyline
Armodafinil
Mirtazapine
zolpidem
Zolpidem tartrate

Genetic Tests for Sleep Disorder

Anatomical Context for Sleep Disorder

MalaCards organs/tissues related to Sleep Disorder:

41
Brain, Heart, Eye, Testes, Breast, Lung, Kidney

Publications for Sleep Disorder

Articles related to Sleep Disorder:

(show top 50) (show all 12374)
# Title Authors PMID Year
1
Optimal Melatonin Dose in Older Adults: A Clinical Review of the Literature. 38 17
31383052 2019
2
Effectiveness and safety of Chinese herbal medicine Xiaoyao san for the treatment of insomnia: Protocol for a systematic review and meta-analysis. 17
31335711 2019
3
Impaired emotional memory and decision-making following primary insomnia. 17
31335727 2019
4
Normalization of breathing with adenotonsillectomy in Japanese pediatric OSA. 38
30799139 2019
5
Research progress on adenosine in central nervous system diseases. 38
31334608 2019
6
Review article: the incidence and risk factors for irritable bowel syndrome in population-based studies. 38
31313850 2019
7
Cannabidiol affects circadian clock core complex and its regulation in microglia cells. 38
30307084 2019
8
Vitamin D and the nervous system. 38
31142227 2019
9
Sleep disturbances in ankylosing spondylitis: a systematic review and meta-analysis. 38
31012756 2019
10
An autopsy case of MM2-thalamic subtype of sporadic Creutzfeldt-Jakob disease with Lewy bodies presenting as a sleep disorder mimicking anti-IgLON5 disease. 38
31325665 2019
11
Untangling narcolepsy and diabetes: Pathomechanisms with eyes on therapeutic options. 38
30998932 2019
12
Sleep disorders in patients with psoriasis: a cross-sectional study using non-polysomnographical methods. 38
30859369 2019
13
Sleep, Sleep Disorders, and Sexual Dysfunction. 38
30209897 2019
14
Utility of transthoracic impedance and novel algorithm for sleep apnea screening in pacemaker patient. 38
30470999 2019
15
Sleep and Memory: The Promise of Precision Medicine. 38
31375205 2019
16
Insomnia and cardiovascular autonomic control. 38
31331688 2019
17
Insomnia severity index: a psychometric investigation among Saudi nurses. 38
30850944 2019
18
An intervention to reduce neuropsychiatric symptoms and caregiver burden in dementia: Preliminary results from a randomized trial of the tailored activity program-outpatient version. 38
30035341 2019
19
Digital cognitive behavioral therapy for insomnia - The first Georgian version. Can we use it in practice? 38
30963032 2019
20
Benefits of selenium in the treatment of depression and sleep disorders : Commentaries of the article "The selenium-containing compound 3-((4-chlorophenyl)selanyl)-1-methyl-1H-indole reverses depressive-like behavior induced by acute restraint stress in mice: modulation of oxido-nitrosative stress and inflammatory pathway". 38
30840199 2019
21
Relationships among personality, coping, and concurrent health-related quality of life in women with breast cancer. 38
30747373 2019
22
Sleep Pharmacogenetics: The Promise of Precision Medicine. 38
31375201 2019
23
Precision Medicine for Sleep Loss and Fatigue Management. 38
31375208 2019
24
Sleep quality is associated with vasopressin methylation in pregnant and postpartum women with a history of psychosocial stress. 38
31132568 2019
25
Measuring Sleep in the Intensive Care Unit: A Critical Appraisal of the Use of Subjective Methods. 38
28631532 2019
26
Alleviation of diazepam-induced conditioned place preference and its withdrawal-associated neurobehavioral deficits following pre-exposure to enriched environment in rats. 38
31145918 2019
27
Prevalence of shift work disorder among hospital personnel: A cross-sectional study using objective working hour data. 38
31410909 2019
28
An automatic single-channel EEG-based sleep stage scoring method based on hidden Markov Model. 38
31228517 2019
29
The prevalence of type 2 diabetes and associated risk factors with generalized osteoarthritis: a retrospective study using ICD codes for clinical data repository system. 38
31392561 2019
30
Sleep and female reproduction. 38
31082843 2019
31
Light therapies to improve sleep in intrinsic circadian rhythm sleep disorders and neuro-psychiatric illness: A systematic review and meta-analysis. 38
31108433 2019
32
Use of antidepressants and the risk of Parkinson's disease in the Local Health Trust of Bologna: A historical cohort study. 38
31422283 2019
33
Sleepwalking and Sleep Paralysis: Prevalence in Colombian Families With Genetic Generalized Epilepsy. 38
31012364 2019
34
Sleep disorders and behavioral disorders in Jamaican children with epilepsy: A case-control study. 38
31425974 2019
35
Postoperative pain following Descemet membrane endothelial keratoplasty (DMEK): a prospective study. 38
31399786 2019
36
Effectiveness of Yi-Zhi-An-Shen granules on cognition and sleep quality in older adults with amnestic mild cognitive impairment: protocol for a randomized, double-blind, placebo-controlled trial. 38
31429790 2019
37
Depressive symptoms and sleep problems as risk factors for heart disease: a prospective community study. 38
31426879 2019
38
Trauma Associated Sleep Disorder: Clinical Developments 5 Years After Discovery. 38
31410580 2019
39
Increased risks of psychiatric disorders in patients with primary Sjögren's syndrome-a secondary cohort analysis of nationwide, population-based health claim data. 38
31372849 2019
40
Associations between tooth wear and dental sleep disorders: A narrative overview. 38
31038764 2019
41
Tics and Tourette Syndrome. 38
31356288 2019
42
[The most common food allergy in children is cow's milk protein allergy]. 38
31401863 2019
43
Insomnia and hot flashes. 38
31239118 2019
44
The association between obstructive sleep apnea and hearing loss: a cross-sectional analysis. 38
31098873 2019
45
Predicting initiation of preventive migraine medications: exploratory study in a large U.S. medical claims database. 38
31422701 2019
46
Neurofibromatosis type 1 (Nf1)-mutant mice exhibit increased sleep fragmentation. 38
30609083 2019
47
Clustering of co-occurring conditions in autism spectrum disorder during early childhood: A retrospective analysis of medical claims data. 38
31149786 2019
48
Use of PROMIS-29® in US Veterans: Diagnostic Concordance and Domain Comparisons with the General Population. 38
31144276 2019
49
The Endocannabinoid System May Modulate Sleep Disorders In Aging. 38
31368874 2019
50
Health-care resource use and current treatment of adult atopic dermatitis patients in Japan: A retrospective claims database analysis. 38
31245879 2019

Variations for Sleep Disorder

Expression for Sleep Disorder

Search GEO for disease gene expression data for Sleep Disorder.

Pathways for Sleep Disorder

GO Terms for Sleep Disorder

Cellular components related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axolemma GO:0030673 8.62 MAPT ADORA1

Biological processes related to Sleep Disorder according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.78 HRH3 HCRTR2 HCRTR1 HCRT
2 rhythmic process GO:0048511 9.71 PER3 PER2 CRY1
3 positive regulation of cold-induced thermogenesis GO:0120162 9.69 PER2 LEP HCRT
4 positive regulation of JAK-STAT cascade GO:0046427 9.57 PRL LEP
5 eating behavior GO:0042755 9.56 LEP HCRT
6 temperature homeostasis GO:0001659 9.55 HCRT ADORA1
7 positive regulation of superoxide anion generation GO:0032930 9.52 MAPT CRP
8 circadian regulation of gene expression GO:0032922 9.5 PER3 PER2 CRY1
9 central nervous system neuron development GO:0021954 9.49 MAPT LEP
10 negative regulation of blood vessel diameter GO:0097756 9.46 CRP ADORA1
11 neuropeptide signaling pathway GO:0007218 9.46 NPS HCRTR2 HCRTR1 HCRT
12 negative regulation of lipid storage GO:0010888 9.43 LEP CRP
13 feeding behavior GO:0007631 9.43 HCRTR2 HCRTR1 HCRT
14 negative regulation of circadian rhythm GO:0042754 9.4 PER2 CRY1
15 negative regulation of glutamate secretion GO:0014050 9.37 HRH3 ADORA1
16 entrainment of circadian clock by photoperiod GO:0043153 9.13 PER3 PER2 CRY1
17 circadian rhythm GO:0007623 8.92 PER3 PER2 LEP CRY1
18 G protein-coupled receptor signaling pathway GO:0007186 10.05 NPS HRH3 HCRTR2 HCRTR1 HCRT ADORA1

Molecular functions related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription corepressor binding GO:0001222 8.96 PER3 PER2
2 orexin receptor activity GO:0016499 8.62 HCRTR2 HCRTR1

Sources for Sleep Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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