MCID: SLP005
MIFTS: 59

Sleep Disorder

Categories: Mental diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Sleep Disorder

MalaCards integrated aliases for Sleep Disorder:

Name: Sleep Disorder 12 15 17
Sleep Disorders 42 15 71 32
Non-Organic Sleep Disorder 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:535
ICD9CM 34 307.4
UMLS 71 C0154564 C0154565 C0851578

Summaries for Sleep Disorder

MedlinePlus : 42 What is sleep? Sleep is a complex biological process. While you are sleeping, you are unconscious, but your brain and body functions are still active. They are doing a number of important jobs that help you stay healthy and function at your best. So when you don't get enough quality sleep, it does more than just make you feel tired. It can affect your physical and mental health, thinking, and daily functioning. What are sleep disorders? Sleep disorders are conditions that disturb your normal sleep patterns. There are more than 80 different sleep disorders. Some major types include Insomnia - being unable to fall asleep and stay asleep. This is the most common sleep disorder. Sleep apnea - a breathing disorder in which you stop breathing for 10 seconds or more during sleep Restless leg syndrome (RLS) - a tingling or prickly sensation in your legs, along with a powerful urge to move them Hypersomnia - being unable to stay awake during the day. This includes narcolepsy, which causes extreme daytime sleepiness. Circadian rhythm disorders - problems with the sleep-wake cycle. They make you unable to sleep and wake at the right times. Parasomnia - acting in unusual ways while falling asleep, sleeping, or waking from sleep, such as walking, talking, or eating Some people who feel tired during the day have a true sleep disorder. But for others, the real problem is not allowing enough time for sleep. It's important to get enough sleep every night. The amount of sleep you need depends on several factors, including your age, lifestyle, health, and whether you have been getting enough sleep recently. Most adults need about 7-8 hours each night. What causes sleep disorders? There are different causes for different sleep disorders, including Other conditions, such as heart disease, lung disease, nerve disorders, and pain Mental illnesses, including depression and anxiety Medicines Genetics Sometimes the cause is unknown. There are also some factors that can contribute to sleep problems, including Caffeine and alcohol An irregular schedule, such as working the night shift Aging. As people age, they often get less sleep or spend less time in the deep, restful stage of sleep. They are also more easily awakened. What are the symptoms of sleep disorders? The symptoms of sleep disorders depend on the specific disorder. Some signs that you may have a sleep disorder include that You regularly take more than 30 minutes each night to fall asleep You regularly wake up several times each night and then have trouble falling back to sleep, or you wake up too early in the morning You often feel sleepy during the day, take frequent naps, or fall asleep at the wrong times during the day Your bed partner says that when you sleep, you snore loudly, snort, gasp, make choking sounds, or stop breathing for short periods You have creeping, tingling, or crawling feelings in your legs or arms that are relieved by moving or massaging them, especially in the evening and when trying to fall asleep Your bed partner notices that your legs or arms jerk often during sleep You have vivid, dreamlike experiences while falling asleep or dozing You have episodes of sudden muscle weakness when you are angry or fearful, or when you laugh You feel as though you cannot move when you first wake up How are sleep disorders diagnosed? To make a diagnosis, your health care provider will use your medical history, your sleep history, and a physical exam. You may also have a sleep study (polysomnogram). The most common types of sleep studies monitor and record data about your body during a full night of sleep. The data includes Brain wave changes Eye movements Breathing rate Blood pressure Heart rate and electrical activity of the heart and other muscles Other types of sleep studies may check how quickly you fall asleep during daytime naps or whether you are able to stay awake and alert during the day. What are the treatments for sleep disorders? Treatments for sleep disorders depend on which disorder you have. They may include Good sleep habits and other lifestyle changes, such as a healthy diet and exercise Cognitive behavioral therapy or relaxation techniques to reduce anxiety about getting enough sleep CPAP (continuous positive airway pressure) machine for sleep apnea Bright light therapy (in the morning) Medicines, including sleeping pills. Usually, providers recommend that you use sleeping pills for a short period of time. Natural products, such as melatonin. These products may help some people but are generally for short-term use. Make sure to check with your health care provider before you take any of them.

MalaCards based summary : Sleep Disorder, also known as sleep disorders, is related to sleep apnea and advanced sleep phase syndrome, familial, 1, and has symptoms including seizures, tremor and fever. An important gene associated with Sleep Disorder is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are Peptide ligand-binding receptors and BMAL1-CLOCK,NPAS2 activates circadian gene expression. The drugs Clonidine and Naltrexone have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A disease of mental health that involves disruption of sleep patterns.

Wikipedia : 74 A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal. Some... more...

Related Diseases for Sleep Disorder

Diseases in the Sleep Disorder family:

Rare Sleep Disorder

Diseases related to Sleep Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 728)
# Related Disease Score Top Affiliating Genes
1 sleep apnea 33.5 NPS LEP INS HCRTR2 HCRT GHRL
2 advanced sleep phase syndrome, familial, 1 33.3 PER3 PER2 CRY1
3 narcolepsy 1 33.3 MOG HCRT
4 advanced sleep phase syndrome 33.2 PER3 PER2 HCRTR2 HCRT CRY1 CLOCK
5 periodic limb movement disorder 33.2 HCRTR2 HCRT FXYD1
6 delayed sleep phase disorder 33.0 PER3 PER2 HCRT CRY1 CLOCK ARNTL
7 rem sleep behavior disorder 33.0 PER2 MAPT HCRT FXYD1 ARNTL
8 narcolepsy 33.0 MOG LEP HCRTR2 HCRTR1 HCRT GHRL
9 recurrent hypersomnia 33.0 PER2 HCRTR2 HCRT
10 migraine with or without aura 1 32.4 PRL NPS LEP INS HCRTR2 HCRT
11 restless legs syndrome 31.9 PRL MAPT HCRT FXYD1 CLOCK
12 central sleep apnea 31.9 LEP HCRT FXYD1 CRP
13 apnea, obstructive sleep 31.7 LEP INS HCRT GHRL FXYD1 CRP
14 cerebrovascular disease 31.5 MAPT LEP INS CRP
15 anxiety 31.4 PRL NPS INS HCRT CRP
16 attention deficit-hyperactivity disorder 31.3 PRL PER2 MOG CLOCK ARNTL
17 fibromyalgia 31.3 LEP INS CRP
18 prader-willi syndrome 31.1 PRL LEP INS HCRT GHRL
19 glucose intolerance 31.1 LEP INS GHRL CRP
20 acromegaly 31.0 PRL LEP INS GHRL
21 hypothyroidism 30.9 PRL LEP INS GHRL CRP
22 substance abuse 30.9 PRL MOG INS
23 polycystic ovary syndrome 30.8 PRL LEP INS GHRL CRP
24 cluster headache 30.8 HCRTR2 CLOCK
25 uremia 30.8 LEP INS CRP
26 eating disorder 30.7 LEP HCRTR1 HCRT GHRL CLOCK
27 amenorrhea 30.6 PRL LEP INS GHRL
28 leptin deficiency or dysfunction 30.6 NPS LEP INS HCRT GHRL CRP
29 major depressive disorder 30.5 PRL PER3 PER2 LEP HCRTR1 HCRT
30 alcohol dependence 30.5 PRL LEP HCRT GHRL
31 body mass index quantitative trait locus 11 30.5 PRL PER2 NPS LEP INS HCRTR2
32 hypertension, essential 30.5 PRL NPS LEP INS GHRL CRP
33 hyperuricemia 30.4 LEP INS CRP
34 rohhad 30.4 HCRTR2 HCRTR1 HCRT
35 disease of mental health 30.4 NPS MAPT LEP INS HCRT CRP
36 peripheral nervous system disease 30.4 NPS MOG INS CRP
37 schizophrenia 30.4 PRL MOG MAPT LEP INS HCRT
38 hypothalamic obesity 30.4 LEP INS
39 bipolar i disorder 30.4 PER3 ARNTL ANK3
40 hyperthyroidism 30.3 PRL LEP INS GHRL CRP
41 bipolar disorder 30.3 PRL PER3 PER2 MAPT LEP CRY1
42 insulin-like growth factor i 30.3 PRL LEP INS
43 hypopituitarism 30.2 PRL LEP INS CRP
44 craniopharyngioma 30.2 PRL INS GHRL
45 glucose metabolism disease 30.2 LEP INS GHRL CRP
46 atypical depressive disorder 30.1 LEP CRP
47 diabetes mellitus, noninsulin-dependent 29.8 TFAP2B NPS LEP INS GHRL CRP
48 rare sleep disorder 12.2
49 non 24 hour sleep wake disorder 12.1
50 idiopathic hypersomnia 11.6

Graphical network of the top 20 diseases related to Sleep Disorder:



Diseases related to Sleep Disorder

Symptoms & Phenotypes for Sleep Disorder

UMLS symptoms related to Sleep Disorder:


seizures, tremor, fever, dyspnea, edema, cachexia, back pain, vertigo, pain, headache, syncope, cyanosis, snoring, chronic pain, sciatica, sleep disturbances, icterus, signs and symptoms, signs and symptoms, digestive, hot flushes, vertigo/dizziness, sleeplessness, nervousness, psychiatric symptom, sluggishness, nightmares, hallucinations, hypnagogic

GenomeRNAi Phenotypes related to Sleep Disorder according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.58 LEP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.58 HCRTR2 LEP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-130 9.58 HCRTR2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.58 FXYD1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.58 ARNTL
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.58 FXYD1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.58 ARNTL
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.58 ARNTL
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.58 LEP
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.58 LEP
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.58 ARNTL
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.58 ARNTL FXYD1 HCRTR2 LEP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.58 FXYD1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.58 ARNTL

MGI Mouse Phenotypes related to Sleep Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 ADORA1 ANK3 ARNTL CLOCK CRY1 GHRL
2 cardiovascular system MP:0005385 10.18 ADORA1 ARNTL CLOCK CRP CRY1 FXYD1
3 homeostasis/metabolism MP:0005376 10.18 ADORA1 ARNTL CLOCK CRP CRY1 GHRL
4 nervous system MP:0003631 10.06 ADORA1 ANK3 ARNTL CLOCK CRY1 HCRT
5 integument MP:0010771 10.02 ADORA1 ARNTL CLOCK CRY1 INS LEP
6 adipose tissue MP:0005375 10 ADORA1 ARNTL CLOCK CRY1 GHRL INS
7 muscle MP:0005369 9.96 ARNTL CRY1 FXYD1 HCRT HCRTR2 INS
8 renal/urinary system MP:0005367 9.56 ADORA1 ANK3 ARNTL INS LEP MAPT
9 vision/eye MP:0005391 9.28 ARNTL CRY1 INS LEP MAPT MOG

Drugs & Therapeutics for Sleep Disorder

Drugs for Sleep Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 478)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonidine Approved Phase 4 4205-90-7 2803
2
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
3
Flunarizine Approved Phase 4 52468-60-7 941361
4
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
5
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
6
Promethazine Approved, Investigational Phase 4 60-87-7 4927
7
Doxepin Approved, Investigational Phase 4 1668-19-5 667477 667468
8
Rasagiline Approved Phase 4 136236-51-6 3052776
9
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 5095 497540
10
Citalopram Approved Phase 4 59729-33-8 2771
11
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
12
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
13
Cobicistat Approved Phase 4 1004316-88-4
14
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
15
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
16
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
17
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
18
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
19
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
20
Cetirizine Approved Phase 4 83881-51-0 2678
21
Levocetirizine Approved Phase 4 130018-77-8 1549000
22
Haloperidol Approved Phase 4 52-86-8 3559
23
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
24
Lacosamide Approved Phase 4 860352-01-8, 175481-36-4 219078
25
Eplerenone Approved Phase 4 107724-20-9 150310 443872
26
Zolpidem Approved Phase 4 82626-48-0 5732
27
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
28
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
29
Ethanol Approved Phase 4 64-17-5 702
30
Estazolam Approved, Illicit Phase 4 29975-16-4 3261
31
Morphine Approved, Investigational Phase 4 57-27-2 5288826
32
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
33
Acetaminophen Approved Phase 4 103-90-2 1983
34
Nefopam Approved, Investigational Phase 4 13669-70-0
35
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
36
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
37
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
38
Pramipexole Approved, Investigational Phase 4 104632-26-0 59868 119570
39
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
40
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
41
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
42
tannic acid Approved Phase 4 1401-55-4
43
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
44
Apomorphine Approved, Investigational Phase 4 58-00-4, 41372-20-7 6005
45
Rotigotine Approved Phase 4 99755-59-6, 92206-54-7 57537
46
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
47
Sodium oxybate Approved Phase 4 502-85-2 5360545
48
Galantamine Approved Phase 4 357-70-0 9651
49
Ribavirin Approved Phase 4 36791-04-5 37542
50
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793

Interventional clinical trials:

(show top 50) (show all 950)
# Name Status NCT ID Phase Drugs
1 Double Bind Randomized Placebo-controlled Cross-over Study to Evaluate Effect of Continuous Apomorphine During the Night on Sleep Disorders in Insomniac Patients With Parkinson's Disease Unknown status NCT02940912 Phase 4 Apomorphine;Placebo
2 Are Patients Suffering From DSPS Show Compromising in Everyday Functions and Abilities (Attention and Concentration, Mood and Fatigue) Before Handling the Disorder? And Whether the Treatment Fixes the Disorder? Unknown status NCT02962037 Phase 4
3 Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder Unknown status NCT00442481 Phase 4 Escitalopram
4 A Comparison Between Two Different Oral Appliance Therapies: Somnodent vs Herbst Appliance in Patients With Mild and Moderate OSA Unknown status NCT02724865 Phase 4
5 Aggressive Behaviour in Children With Tourette's Syndrome (TS) and Comorbid Attention Deficit Hyperactivity Disorder (ADHD) Unknown status NCT00152750 Phase 4 APO-clonidine
6 Sleep Disturbances in Hospitalized Children Unknown status NCT00749814 Phase 4
7 Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? A Randomized, Double-blinded, Placebo-controlled, Crossover Study. Unknown status NCT02806440 Phase 4 Low dose naltrexone;Placebo
8 Pilot Study: The Effect of Rozerem on Sleep Disturbance After Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
9 Neurologic Signatures of Chronic Pain Disorders Unknown status NCT02747940 Phase 4 flunarizine and/or pregabalin
10 Influence on Incidence of Postoperative Delirium by Various Sedatives in Elderly Patients With Hip Fracture Under Lumbar Anesthesia: A Randomized, Control and Multi-center Trial Unknown status NCT03346226 Phase 4 Dexmedetomidine Hydrochloride;Propofol
11 Comparison of Effect of Peritonsillar Infiltration of Ketamine and Tramadol on Pediatric Posttonsillectomy Pain: A Double-blinded Randomized Placebo-controlled Clinical Trial Unknown status NCT03067103 Phase 4 Tramadol;Ketamine;Placebos
12 Effects of Gabapentin Enacarbil on Intensity of Cortical Arousal, Heart Rate, Blood Pressure and Anterior Tibialis EMG Responses Associated With PLMs During Sleep in Patients With RLS Using a Novel Computer Assisted Scoring System Unknown status NCT02424695 Phase 4 Gabapentin Enacarbil (GEn);Placebo
13 Examination of the Effectiveness of Suvorexant in Improving Daytime Sleep in Shift Workers Completed NCT02491788 Phase 4 Suvorexant;Placebo
14 Assessments in Stress and Quality of Sleep/Life in Night-shift Nurses and Doctors Completed NCT02541747 Phase 4
15 Delayed Sleep Phase Syndrome in Adolescents and Young Adults. Sleep, Personality, Developmental History, Circadian Rhythm, Daytime Functioning and Treatment Completed NCT00834886 Phase 4
16 Phase IV 4 Way Crossover Study to Assess and Compare the Effect of a Single Nighttime Administration of Zolpidem, Silenor and Placebo on Arousability, Ataxia/Balance and Cognitive Performance in Healthy Volunteers. Completed NCT02353299 Phase 4 Silenor 6 mg;zolpidem 10 mg;Placebo;Placebo
17 The Effect of Armodafinil (Nuvigil) on Fatigue and Quality of Life in Peri- and Postmenopausal Women Completed NCT01460628 Phase 4 Armodafinil
18 Effects of Rasagiline on Sleep Disturbances in PD: A Single Center, Randomized, Double-blind, Placebo run-in, Polysomnographic Clinical Phase IV Trial Completed NCT01442610 Phase 4 Rasagiline;Placebo
19 Effect of Zolpidem vs Placebo on Insomnia and Daytime Function in Patients With Insomnia Associated With Osteoarthritis Completed NCT00530556 Phase 4 zolpidem
20 An Open Assessment of the Effect of Low-Dose Totelle® 1 mg on Menopausal Symptoms, Sexual Function and Quality of Life Completed NCT00195520 Phase 4 Totelle®
21 Single Blind, Multi-center, Post Marketing Clinical Study of Zolpidem (Myslee) in Adolescent Patients With Insomnia - Evaluation With Polysomnography Completed NCT00653562 Phase 4 zolpidem
22 National, Multicenter, Open Label, Phase IV, Before-after Design Study, in Adult Patients With Primary Insomnia to Evaluate Sleep Satisfaction and Psychomotor Performance After 1 Month of Treatment With Zolpidem CR (Ambien®CR) in 6 Sites in Argentina Completed NCT01097382 Phase 4 ZOLPIDEM
23 Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome With Major Depressive Disorder or Dysthymic Disorder Completed NCT00518986 Phase 4 armodafinil;placebo
24 Switching From Atripla to Stribild Leads to Improvements in Central Nervous System Side Effects and Sleep Disturbances Completed NCT02477527 Phase 4 Stribild
25 Efficacy and Safety Assessment of ZOlpidem (Stilnox CR) Administered on as Needed Basis in Patients With Chronic insomNIA Completed NCT01024192 Phase 4 ZOLPIDEM SL800750
26 Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in ICD Patients Completed NCT00708786 Phase 4
27 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed NCT01234675 Phase 4 Milnacipran;Placebo
28 Randomized, Double-Blinded Clinical Trial to Evaluate the Incidence and Severity of Neuropsychiatric Side Effects and Antiviral Efficacy of Efavirenz Given as a Stepped Dosage Over 2 Weeks Versus the Usual Dosage in HIV-Infected Patients. Completed NCT00556634 Phase 4 Efavirenz
29 Behavioral and Pharmacological Treatment for Insomnia Completed NCT00042146 Phase 4 zolpidem
30 Paroxetine in the Treatment of Chronic Primary Insomnia: A Double-Blind, Randomized, Placebo-Controlled Study of Efficacy Over Six Weeks Completed NCT00178048 Phase 4 paroxetine
31 The Impact of Gastroesophageal Reflux Disease in Sleep Disorders: A Pilot Investigation of Rabeprazole, 20 mg Twice Daily for the Relief of GERD-Related Insomnia. Completed NCT00287391 Phase 4 Rabeprazole
32 An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue Completed NCT00678691 Phase 4 armodafinil;placebo
33 A Randomized Placebo-controlled Trial Evaluating the Effect of Melatonin on Sleep Quality in Patients With Dementia Completed NCT03066518 Phase 4 Melatonin 5 mg
34 Hydromorphone OROS in Korean Cancer Patients: Evaluation of Its Clinical Usefulness in Improvement of Sleep Disturbance Completed NCT00766831 Phase 4 Hydromorphone
35 Placebo Controlled Pilot Study on the Efficacy of Levocetirizine 5 mg in Reducing Symptoms, Airway Resistance, and Sleep Impairment in Patients With Persistent Allergic Rhinitis Completed NCT00355771 Phase 4 Levocetirizine;Placebo
36 A Phase IV 3-Way Double-blind, Randomized, Crossover Study to Compare the Awakening Threshold Effects (Responsivity) of Belsomra 10 mg and 20 mg to Placebo in Non-elderly Insomniacs Completed NCT03312517 Phase 4 Suvorexant 10 mg;Suvorexant 20 mg;Placebo oral capsule
37 Experimental Study of Mobile Base Station Related Radio-Frequency Electromagnetic Radiation in Healthy Adults and Adolescents Completed NCT00138905 Phase 4
38 Phase 4 Study of the Effects of Modafinil on Waking Function and on Sleep in Individuals With Primary Insomnia Completed NCT00124384 Phase 4 modafinil
39 Efficacy and Safety of Eszopiclone (Lunesta) in Nursing Home Patients Completed NCT00460993 Phase 4 Lunesta
40 Cognitive-Behavior Therapy for Insomnia: Component Analysis and Treatment Completed NCT00869934 Phase 4
41 A Single Dose, Open-Label, Randomized Two-Period Crossover Study in Healthy Young Subjects to Assess the Absolute Bioavailability of Tasimelteon (HETLIOZ™) Completed NCT02130999 Phase 4 tasimelteon 20 mg capsule;tasimelteon 2 mg I.V.
42 Progesterone Reduces Wakefulness in Sleep EEG and Has no Effect on Cognition in Healthy Postmenopausal Women Completed NCT00530582 Phase 4 progesterone
43 Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia Completed NCT03075657 Phase 4 Risperidone;Risperidone and Ramelteon;Haloperidol;Haloperidol and Ramelteon
44 Impact of Smoking Cessation on Sleep Completed NCT00132821 Phase 4 Bupropion;Transdermal Nicotine Patch;Placebo Bupropion;Placebo transdermal nicotine patch
45 Eszopiclone and Inflammatory Mediators in Patients With Acute Coronary Syndrome Completed NCT00822679 Phase 4 Eszopiclone
46 A Randomized, Double Blind, Study to Evaluate the Efficacy of Nasal Nicotine Spray to Reduce Post-Operative Opioid Requirements in Nonsmokers in Elective Laparoscopic Bariatric Surgical Patients Completed NCT01194089 Phase 4 Nasal Nicotine Spray;Nasal Normal Saline Spray
47 Improving Sleep in Nursing Homes Completed NCT00576927 Phase 4 Ramelteon;Placebo
48 Searching for "Sleep Friendly" Therapies for a Sleepy Population: A Double-Blind, Placebo-Controlled, Randomized Trial to Assess the Effects of Lacosamide on Sleep and Wake in Adults With Focal Epilepsy Completed NCT01190098 Phase 4 Lacosamide;Placebo
49 Sleep Apnea. Concordance Between Non-reference and Reference Centres Completed NCT00424658 Phase 4
50 Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil Completed NCT01965925 Phase 4 Modafinil;Placebo

Search NIH Clinical Center for Sleep Disorder

Inferred drug relations via UMLS 71 / NDF-RT 50 :


zolpidem
Zolpidem tartrate

Genetic Tests for Sleep Disorder

Anatomical Context for Sleep Disorder

MalaCards organs/tissues related to Sleep Disorder:

40
Brain, Heart, Eye, Testes, Kidney, Breast, Lung

Publications for Sleep Disorder

Articles related to Sleep Disorder:

(show top 50) (show all 12832)
# Title Authors PMID Year
1
Assessment of sleep and obesity in adults and children: Observational study. 42
31725607 2019
2
Traditional Chinese medicine non-pharmaceutical therapies for chronic adult insomnia: A Bayesian network meta-analysis protocol. 42
31725615 2019
3
Effectiveness and safety of acupuncture for insomnia: Protocol for a systematic review. 42
31702639 2019
4
Utility of the Sleep Disorders Inventory for Students in Clinically Referred Youth With Insomnia: Risk Identification and Relationship With Polysomnographic Measures. 61
30793972 2020
5
Sex and age differentially affect GABAergic neurons in the mouse prefrontal cortex and hippocampus following chronic intermittent hypoxia. 61
31837319 2020
6
Impact of an Individually Tailored Light Mask on Sleep Parameters in Older Adults With Advanced Phase Sleep Disorder. 61
30588849 2020
7
Premature birth, homeostatic plasticity and respiratory consequences of inflammation. 61
31733340 2020
8
The association of short-term effects of air pollution and sleep disorders among elderly residents in China. 61
31780155 2020
9
Insomnia and Cognitive Performance. 61
32005351 2020
10
Measurement invariance, validation and normative data of the Jenkins Sleep Scale-4 (JSS-4) in the German general population across the life span. 61
31951963 2020
11
A sleep intervention study comparing effects of sleep restriction and fragmentation on sleep and vigilance and the need for recovery. 61
31874181 2020
12
Insomnia Disorder and Behaviorally Induced Insufficient Sleep Syndrome: Prevalence and Relationship to Depression in College Students. 61
30789063 2020
13
[Using the FOCUS Family Intervention for Family-Centered Care in a Premature Infant With Grade IV Intraventricular Hemorrhage]. 61
31960402 2020
14
The impact of obstructive sleep apnoea on balance, gait and falls risk: a narrative review of the literature. 61
32039438 2020
15
Maternal sleep disturbances in late pregnancy and the association with emergency caesarean section: A prospective cohort study. 61
31919015 2020
16
Does insomnia predict a high risk of cancer? A systematic review and meta-analysis of cohort studies. 61
31352687 2020
17
Reduced structural connectivity in Insomnia Disorder. 61
31515853 2020
18
Positive oligoclonal bands and CSF pleocytosis in narcolepsy type 1: A case report supporting the immune-mediated hypothesis. 61
31756639 2020
19
Validity, potential clinical utility, and comparison of consumer and research-grade activity trackers in Insomnia Disorder I: In-lab validation against polysomnography. 61
31626361 2020
20
Long-term sleep disturbance and prescription sleep aid use among cancer survivors in the United States. 61
31081525 2020
21
Infographic. Sleep disorders in athletes. 61
31227492 2020
22
Sleep disorders in children with Angelman and Smith-Magenis syndromes: The assessment of potential causes of disrupted settling and night time waking. 61
31838315 2020
23
The Functional Impact of Sleep Disorders in Children With ADHD. 61
28093033 2020
24
An unbiased, efficient sleep-wake detection algorithm for a population with sleep disorders: Change Point Decoder. 61
32006429 2020
25
Insomnia, sleepiness, anxiety and depression among different types of gamers in African countries. 61
32029773 2020
26
Circadian Rhythm and Glaucoma: What do We Know? 61
31693644 2020
27
Childhood Dystonia-Parkinsonism Following Infantile Spasms-Clinical Clue to Diagnosis in Early Beta-Propeller Protein-Associated Neurodegeneration. 61
31505688 2020
28
Practice patterns of board-certified sleep medicine providers: A national analysis among older adult Medicare beneficiaries. 61
32024587 2020
29
Sleep disturbances among older adults following traumatic brain injury. 61
31547739 2020
30
Association of Sleep Apnea with Mortality in Patients with Advanced Kidney Disease. 61
31969341 2020
31
Association between symptoms of sleep apnea and problem behaviors in young adult twins and siblings. 61
32026794 2020
32
Artificial Intelligence in Sleep Medicine: An American Academy of Sleep Medicine Position Statement. 61
32022674 2020
33
Shift Workers at Risk for Metabolic Syndrome. 61
31985761 2020
34
A review of the incidence and risk factors for fibromyalgia and chronic widespread pain in population-based studies. 61
32040078 2020
35
Mental health issues and psychological factors in athletes: detection, management, effect on performance and prevention: American Medical Society for Sports Medicine Position Statement-Executive Summary. 61
31810972 2020
36
Excess abdominal fat is associated with cutaneous allodynia in individuals with migraine: a prospective cohort study. 61
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37
Squalene Synthase Deficiency 61
32027475 2020
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Overview of Sleep and Circadian Rhythm Disorders in Parkinson Disease. 61
31733692 2020
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Hypothalamic orexin and mechanistic target of rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex. 61
31605778 2020
40
Relations Between Sleep and Temperament in Preschool Children With ADHD. 61
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41
Why do older workers with chronic health conditions prefer to retire early? 61
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42
Giving a voice to Cataplectic experience: recalls from patients with narcolepsy type 1. 61
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43
Associations of occupational stress, workplace violence and organizational support on chronic fatigue symptoms among nurses. 61
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44
A novel sleep stage scoring system: Combining expert-based features with the generalized linear model. 61
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Sex differences in incidence and psychiatric comorbidity for alcohol dependence in patients with panic disorder. 61
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Therapy for Insomnia and Circadian Rhythm Disorder in Alzheimer Disease. 61
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Practical considerations for the evaluation and management of Attention Deficit Hyperactivity Disorder (ADHD) in adults. 61
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Atopic dermatitis and psychosocial comorbidities. 61
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Medical Cannabis as a Treatment for Patients With Epilepsy, Sleep Disorders, and Posttraumatic Stress Disorder. 61
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Insomnia and poor sleep quality are associated with poor seizure control in patients with epilepsy. 61
31937418 2020

Variations for Sleep Disorder

Expression for Sleep Disorder

Search GEO for disease gene expression data for Sleep Disorder.

Pathways for Sleep Disorder

Pathways related to Sleep Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 PRL NPS LEP HCRTR2 HCRTR1 HCRT
2
Show member pathways
11.99 PER2 CRY1 CLOCK ARNTL
4 11.31 PER2 CRY1 CLOCK ARNTL
5 11.28 PRL LEP INS
6
Show member pathways
11.19 PER3 PER2 CRY1 CLOCK ARNTL
7 10.92 PER3 PER2 CRY1 CLOCK ARNTL
8 10.86 PRL LEP INS GHRL
9 10.62 CLOCK ARNTL
10
Show member pathways
10.62 CRY1 CLOCK ARNTL

GO Terms for Sleep Disorder

Cellular components related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.17 TFAP2B MAPT HCRTR2 HCRTR1 HCRT GHRL
2 axolemma GO:0030673 9.16 MAPT ADORA1
3 chromatoid body GO:0033391 8.96 CLOCK ARNTL

Biological processes related to Sleep Disorder according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.16 PRL MAPT LEP INS HCRTR2 HCRTR1
2 G protein-coupled receptor signaling pathway GO:0007186 10.15 NPS INS HCRTR2 HCRTR1 HCRT GHRL
3 negative regulation of transcription, DNA-templated GO:0045892 10.04 TFAP2B PER2 CRY1 CLOCK ARNTL
4 glucose homeostasis GO:0042593 9.83 TFAP2B LEP INS CRY1
5 neuropeptide signaling pathway GO:0007218 9.8 NPS HCRTR2 HCRTR1 HCRT
6 positive regulation of cold-induced thermogenesis GO:0120162 9.78 PER2 LEP HCRT GHRL
7 excitatory postsynaptic potential GO:0060079 9.77 HCRT GHRL ADORA1
8 regulation of circadian rhythm GO:0042752 9.77 PER2 CRY1 CLOCK
9 rhythmic process GO:0048511 9.77 PER3 PER2 CRY1 CLOCK ARNTL
10 response to nutrient levels GO:0031667 9.76 PRL LEP GHRL
11 feeding behavior GO:0007631 9.71 HCRTR2 HCRTR1 HCRT
12 glucose metabolic process GO:0006006 9.71 TFAP2B LEP INS GHRL
13 response to light stimulus GO:0009416 9.69 PER3 PER2 CRY1
14 negative regulation of lipid catabolic process GO:0050995 9.65 INS ADORA1
15 fatty acid homeostasis GO:0055089 9.64 INS ADORA1
16 central nervous system neuron development GO:0021954 9.63 MAPT LEP
17 response to redox state GO:0051775 9.63 CLOCK ARNTL
18 negative regulation of circadian rhythm GO:0042754 9.62 PER2 CRY1
19 adult feeding behavior GO:0008343 9.62 LEP GHRL
20 negative regulation of lipid storage GO:0010888 9.61 LEP CRP
21 entrainment of circadian clock by photoperiod GO:0043153 9.61 PER3 PER2 CRY1
22 magnesium ion homeostasis GO:0010960 9.58 TFAP2B ANK3
23 negative regulation of acute inflammatory response GO:0002674 9.57 INS ADORA1
24 regulation of hair cycle GO:0042634 9.56 CLOCK ARNTL
25 regulation of type B pancreatic cell development GO:2000074 9.55 CLOCK ARNTL
26 regulation of insulin secretion GO:0050796 9.55 TFAP2B PER2 LEP CLOCK ARNTL
27 negative regulation of blood vessel diameter GO:0097756 9.5 INS CRP ADORA1
28 negative regulation of glucocorticoid receptor signaling pathway GO:2000323 9.43 CRY1 CLOCK ARNTL
29 circadian regulation of gene expression GO:0032922 9.35 PER3 PER2 CRY1 CLOCK ARNTL
30 circadian rhythm GO:0007623 9.1 PER3 PER2 LEP CRY1 CLOCK ARNTL

Molecular functions related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region sequence-specific DNA binding GO:0000976 9.43 PER3 PER2 ARNTL
2 E-box binding GO:0070888 9.33 CRY1 CLOCK ARNTL
3 transcription corepressor binding GO:0001222 9.32 PER3 PER2
4 hormone activity GO:0005179 9.26 PRL LEP INS GHRL
5 orexin receptor activity GO:0016499 8.62 HCRTR2 HCRTR1

Sources for Sleep Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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