Sleep Disorder

Categories: Mental diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Sleep Disorder

MalaCards integrated aliases for Sleep Disorder:

Name: Sleep Disorder 12 15 17
Sleep Disorders 42 15 71 32
Non-Organic Sleep Disorder 12 71


External Ids:

Disease Ontology 12 DOID:535
ICD9CM 34 307.4
UMLS 71 C0154564 C0154565 C0851578

Summaries for Sleep Disorder

MedlinePlus : 42 What is sleep? Sleep is a complex biological process. While you are sleeping, you are unconscious, but your brain and body functions are still active. They are doing a number of important jobs that help you stay healthy and function at your best. So when you don't get enough quality sleep, it does more than just make you feel tired. It can affect your physical and mental health, thinking, and daily functioning. What are sleep disorders? Sleep disorders are conditions that disturb your normal sleep patterns. There are more than 80 different sleep disorders. Some major types include Insomnia - being unable to fall asleep and stay asleep. This is the most common sleep disorder. Sleep apnea - a breathing disorder in which you stop breathing for 10 seconds or more during sleep Restless leg syndrome (RLS) - a tingling or prickly sensation in your legs, along with a powerful urge to move them Hypersomnia - being unable to stay awake during the day. This includes narcolepsy, which causes extreme daytime sleepiness. Circadian rhythm disorders - problems with the sleep-wake cycle. They make you unable to sleep and wake at the right times. Parasomnia - acting in unusual ways while falling asleep, sleeping, or waking from sleep, such as walking, talking, or eating Some people who feel tired during the day have a true sleep disorder. But for others, the real problem is not allowing enough time for sleep. It's important to get enough sleep every night. The amount of sleep you need depends on several factors, including your age, lifestyle, health, and whether you have been getting enough sleep recently. Most adults need about 7-8 hours each night. What causes sleep disorders? There are different causes for different sleep disorders, including Other conditions, such as heart disease, lung disease, nerve disorders, and pain Mental illnesses, including depression and anxiety Medicines Genetics Sometimes the cause is unknown. There are also some factors that can contribute to sleep problems, including Caffeine and alcohol An irregular schedule, such as working the night shift Aging. As people age, they often get less sleep or spend less time in the deep, restful stage of sleep. They are also more easily awakened. What are the symptoms of sleep disorders? The symptoms of sleep disorders depend on the specific disorder. Some signs that you may have a sleep disorder include that You regularly take more than 30 minutes each night to fall asleep You regularly wake up several times each night and then have trouble falling back to sleep, or you wake up too early in the morning You often feel sleepy during the day, take frequent naps, or fall asleep at the wrong times during the day Your bed partner says that when you sleep, you snore loudly, snort, gasp, make choking sounds, or stop breathing for short periods You have creeping, tingling, or crawling feelings in your legs or arms that are relieved by moving or massaging them, especially in the evening and when trying to fall asleep Your bed partner notices that your legs or arms jerk often during sleep You have vivid, dreamlike experiences while falling asleep or dozing You have episodes of sudden muscle weakness when you are angry or fearful, or when you laugh You feel as though you cannot move when you first wake up How are sleep disorders diagnosed? To make a diagnosis, your health care provider will use your medical history, your sleep history, and a physical exam. You may also have a sleep study (polysomnogram). The most common types of sleep studies monitor and record data about your body during a full night of sleep. The data includes Brain wave changes Eye movements Breathing rate Blood pressure Heart rate and electrical activity of the heart and other muscles Other types of sleep studies may check how quickly you fall asleep during daytime naps or whether you are able to stay awake and alert during the day. What are the treatments for sleep disorders? Treatments for sleep disorders depend on which disorder you have. They may include Good sleep habits and other lifestyle changes, such as a healthy diet and exercise Cognitive behavioral therapy or relaxation techniques to reduce anxiety about getting enough sleep CPAP (continuous positive airway pressure) machine for sleep apnea Bright light therapy (in the morning) Medicines, including sleeping pills. Usually, providers recommend that you use sleeping pills for a short period of time. Natural products, such as melatonin. These products may help some people but are generally for short-term use. Make sure to check with your health care provider before you take any of them.

MalaCards based summary : Sleep Disorder, also known as sleep disorders, is related to sleep apnea and advanced sleep phase syndrome, and has symptoms including seizures, fever and dyspnea. An important gene associated with Sleep Disorder is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are Peptide ligand-binding receptors and AMP-activated Protein Kinase (AMPK) Signaling. The drugs Clonidine and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A disease of mental health that involves disruption of sleep patterns.

Wikipedia : 74 A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person. Some sleep... more...

Related Diseases for Sleep Disorder

Diseases in the Sleep Disorder family:

Rare Sleep Disorder

Diseases related to Sleep Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 736)
# Related Disease Score Top Affiliating Genes
1 sleep apnea 33.6 NPS LEP INS HCRT GHRL CRP
2 advanced sleep phase syndrome 33.4 PER3 PER2 HCRTR2 HCRT CRY1 ARNTL
3 narcolepsy 1 33.3 MOG HCRT
4 kleine-levin hibernation syndrome 33.3 SLC6A3 HCRT
5 periodic limb movement disorder 33.2 HCRTR2 HCRT FXYD1
6 delayed sleep phase disorder 33.2 PER3 PER2 HCRT CRY1 ARNTL
7 narcolepsy 33.0 SLC6A3 MOG LEP HCRTR2 HCRTR1 HCRT
8 recurrent hypersomnia 32.9 SLC6A3 HCRTR2 HCRT
9 rem sleep behavior disorder 32.9 SLC6A3 PER2 MAPT HCRT FXYD1 ARNTL
10 advanced sleep phase syndrome, familial, 1 32.9 PER3 PER2 CRY1
11 migraine with or without aura 1 32.4 SLC6A3 PRL NPS LEP INS HCRTR2
12 central sleep apnea 32.0 LEP HCRT CRP
13 restless legs syndrome 32.0 SLC6A3 PRL MAPT HCRT FXYD1
14 apnea, obstructive sleep 31.8 LEP INS HCRT GHRL FXYD1 CRP
15 attention deficit-hyperactivity disorder 31.4 SLC6A3 PRL PER2 MOG ARNTL
16 fibromyalgia 31.4 PRL LEP CRP
17 anxiety 31.4 SLC6A3 PRL NPS INS HCRT CRP
18 cerebrovascular disease 31.3 MAPT LEP INS CRP
19 prader-willi syndrome 31.2 PRL LEP INS HCRT GHRL
20 mental depression 31.2 SLC6A3 NPS CRP
21 glucose intolerance 31.2 LEP INS GHRL CRP
22 fatal familial insomnia 31.1 PER2 MAPT HCRT
23 alcohol dependence 31.1 SLC6A3 PRL LEP HCRT GHRL
24 acromegaly 31.1 PRL LEP INS GHRL
25 substance abuse 31.1 SLC6A3 PRL MOG INS
26 chronic fatigue syndrome 31.0 PRL LEP INS
27 hypothyroidism 31.0 PRL LEP INS GHRL CRP
28 supranuclear palsy, progressive, 1 30.9 SLC6A3 MAPT HCRT
29 polycystic ovary syndrome 30.9 PRL LEP INS GHRL CRP
30 uremia 30.9 LEP INS CRP
31 autism 30.7 SLC6A3 PRL MAPT LEP HCRT ANK3
32 eating disorder 30.7 SLC6A3 LEP HCRTR1 HCRT GHRL
33 panic disorder 30.6 SLC6A3 PRL HCRTR1 GHRL ADORA1
34 amenorrhea 30.6 PRL LEP INS GHRL
35 leptin deficiency or dysfunction 30.6 NPS LEP INS HCRT GHRL CRP
36 hypertension, essential 30.6 PRL NPS LEP INS GHRL CRP
37 body mass index quantitative trait locus 11 30.5 SLC6A3 PRL PER2 NPS LEP INS
38 schizophrenia 30.5 SLC6A3 PRL MOG MAPT LEP INS
39 hyperuricemia 30.5 LEP INS CRP
40 rohhad 30.4 HCRTR2 HCRTR1 HCRT
41 hypothalamic obesity 30.4 LEP INS
42 peripheral nervous system disease 30.4 NPS MOG LEP INS CRP
43 hyperthyroidism 30.4 PRL LEP INS GHRL CRP
44 major depressive disorder 30.4 SLC6A3 PRL PER3 PER2 NPS LEP
45 bipolar disorder 30.4 SLC6A3 PRL PER3 PER2 MAPT LEP
46 bipolar i disorder 30.4 PER3 ARNTL ANK3
47 neuromyelitis optica 30.4 MOG HCRT CRP
48 disease of mental health 30.4 SLC6A3 NPS MAPT LEP INS HCRT
49 insulin-like growth factor i 30.3 PRL LEP INS
50 hypopituitarism 30.3 PRL LEP INS CRP

Graphical network of the top 20 diseases related to Sleep Disorder:

Diseases related to Sleep Disorder

Symptoms & Phenotypes for Sleep Disorder

UMLS symptoms related to Sleep Disorder:

seizures, fever, dyspnea, edema, tremor, cachexia, back pain, vertigo, headache, syncope, cyanosis, pain, chronic pain, sciatica, snoring, sleep disturbances, icterus, signs and symptoms, signs and symptoms, digestive, hot flushes, vertigo/dizziness, sleeplessness, nervousness, psychiatric symptom, sluggishness, nightmares, hallucinations, hypnagogic

GenomeRNAi Phenotypes related to Sleep Disorder according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-100 9.5 FXYD1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-122 9.5 FXYD1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 9.5 HCRTR2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.5 FXYD1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.5 ARNTL
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-185 9.5 HCRTR2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-190 9.5 FXYD1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-199 9.5 ARNTL
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.5 HCRTR2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-4 9.5 FXYD1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 9.5 ARNTL
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 9.5 FXYD1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.5 ARNTL
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.5 ARNTL
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.5 FXYD1

MGI Mouse Phenotypes related to Sleep Disorder:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 ADORA1 ANK3 ARNTL CRY1 GHRL HCRT
2 homeostasis/metabolism MP:0005376 10.18 ADORA1 ARNTL CRP CRY1 GHRL HCRT
3 cardiovascular system MP:0005385 10.14 ADORA1 ARNTL CRP CRY1 FXYD1 HCRT
4 nervous system MP:0003631 10.06 ADORA1 ANK3 ARNTL CRY1 HCRT HCRTR1
5 integument MP:0010771 10.02 ADORA1 ARNTL CRY1 INS LEP MAPT
6 muscle MP:0005369 10 ARNTL CRY1 FXYD1 HCRT HCRTR2 INS
7 renal/urinary system MP:0005367 9.56 ADORA1 ANK3 ARNTL INS LEP MAPT
8 vision/eye MP:0005391 9.28 ARNTL CRY1 INS LEP MAPT MOG

Drugs & Therapeutics for Sleep Disorder

Drugs for Sleep Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 444)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Clonidine Approved Phase 4 4205-90-7 2803
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
Flunarizine Approved Phase 4 52468-60-7 941361
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Doxepin Approved, Investigational Phase 4 1668-19-5 667477 667468
Rasagiline Approved Phase 4 136236-51-6 3052776
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 497540 5095
Citalopram Approved Phase 4 59729-33-8 2771
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
Cobicistat Approved Phase 4 1004316-88-4
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
Levocetirizine Approved Phase 4 130018-77-8 1549000
Haloperidol Approved Phase 4 52-86-8 3559
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
Lacosamide Approved Phase 4 175481-36-4, 860352-01-8 219078
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
Eplerenone Approved Phase 4 107724-20-9 150310 443872
Zolpidem Approved Phase 4 82626-48-0 5732
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
Ethanol Approved Phase 4 64-17-5 702
Estazolam Approved, Illicit Phase 4 29975-16-4 3261
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Acetaminophen Approved Phase 4 103-90-2 1983
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Nefopam Approved, Investigational Phase 4 13669-70-0
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Pramipexole Approved, Investigational Phase 4 104632-26-0 119570 59868
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
tannic acid Approved Phase 4 1401-55-4
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
Apomorphine Approved, Investigational Phase 4 41372-20-7, 58-00-4 6005
Rotigotine Approved Phase 4 99755-59-6, 92206-54-7 57537
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
Sodium oxybate Approved Phase 4 502-85-2 5360545
Galantamine Approved Phase 4 357-70-0 9651
Ribavirin Approved Phase 4 36791-04-5 37542
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205

Interventional clinical trials:

(show top 50) (show all 1024)
# Name Status NCT ID Phase Drugs
1 Double Bind Randomized Placebo-controlled Cross-over Study to Evaluate Effect of Continuous Apomorphine During the Night on Sleep Disorders in Insomniac Patients With Parkinson's Disease Unknown status NCT02940912 Phase 4 Apomorphine;Placebo
2 Are Patients Suffering From DSPS Show Compromising in Everyday Functions and Abilities (Attention and Concentration, Mood and Fatigue) Before Handling the Disorder? And Whether the Treatment Fixes the Disorder? Unknown status NCT02962037 Phase 4
3 Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder Unknown status NCT00442481 Phase 4 Escitalopram
4 A Comparison Between Two Different Oral Appliance Therapies: Somnodent vs Herbst Appliance in Patients With Mild and Moderate OSA Unknown status NCT02724865 Phase 4
5 Aggressive Behaviour in Children With Tourette's Syndrome (TS) and Comorbid Attention Deficit Hyperactivity Disorder (ADHD) Unknown status NCT00152750 Phase 4 APO-clonidine
6 Sleep Disturbances in Hospitalized Children Unknown status NCT00749814 Phase 4
7 Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? A Randomized, Double-blinded, Placebo-controlled, Crossover Study. Unknown status NCT02806440 Phase 4 Low dose naltrexone;Placebo
8 Pilot Study: The Effect of Rozerem on Sleep Disturbance After Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
9 Neurologic Signatures of Chronic Pain Disorders Unknown status NCT02747940 Phase 4 flunarizine and/or pregabalin
10 Influence on Incidence of Postoperative Delirium by Various Sedatives in Elderly Patients With Hip Fracture Under Lumbar Anesthesia: A Randomized, Control and Multi-center Trial Unknown status NCT03346226 Phase 4 Dexmedetomidine Hydrochloride;Propofol
11 Comparison of Effect of Peritonsillar Infiltration of Ketamine and Tramadol on Pediatric Posttonsillectomy Pain: A Double-blinded Randomized Placebo-controlled Clinical Trial Unknown status NCT03067103 Phase 4 Tramadol;Ketamine;Placebos
12 Effects of Gabapentin Enacarbil on Intensity of Cortical Arousal, Heart Rate, Blood Pressure and Anterior Tibialis EMG Responses Associated With PLMs During Sleep in Patients With RLS Using a Novel Computer Assisted Scoring System Unknown status NCT02424695 Phase 4 Gabapentin Enacarbil (GEn);Placebo
13 Examination of the Effectiveness of Suvorexant in Improving Daytime Sleep in Shift Workers Completed NCT02491788 Phase 4 Suvorexant;Placebo
14 Assessments in Stress and Quality of Sleep/Life in Night-shift Nurses and Doctors Completed NCT02541747 Phase 4
15 Delayed Sleep Phase Syndrome in Adolescents and Young Adults. Sleep, Personality, Developmental History, Circadian Rhythm, Daytime Functioning and Treatment Completed NCT00834886 Phase 4
16 Phase IV 4 Way Crossover Study to Assess and Compare the Effect of a Single Nighttime Administration of Zolpidem, Silenor and Placebo on Arousability, Ataxia/Balance and Cognitive Performance in Healthy Volunteers. Completed NCT02353299 Phase 4 Silenor 6 mg;zolpidem 10 mg;Placebo;Placebo
17 The Effect of Armodafinil (Nuvigil) on Fatigue and Quality of Life in Peri- and Postmenopausal Women Completed NCT01460628 Phase 4 Armodafinil
18 Effects of Rasagiline on Sleep Disturbances in PD: A Single Center, Randomized, Double-blind, Placebo run-in, Polysomnographic Clinical Phase IV Trial Completed NCT01442610 Phase 4 Rasagiline;Placebo
19 Effect of Zolpidem vs Placebo on Insomnia and Daytime Function in Patients With Insomnia Associated With Osteoarthritis Completed NCT00530556 Phase 4 zolpidem
20 An Open Assessment of the Effect of Low-Dose Totelle® 1 mg on Menopausal Symptoms, Sexual Function and Quality of Life Completed NCT00195520 Phase 4 Totelle®
21 Single Blind, Multi-center, Post Marketing Clinical Study of Zolpidem (Myslee) in Adolescent Patients With Insomnia - Evaluation With Polysomnography Completed NCT00653562 Phase 4 zolpidem
22 National, Multicenter, Open Label, Phase IV, Before-after Design Study, in Adult Patients With Primary Insomnia to Evaluate Sleep Satisfaction and Psychomotor Performance After 1 Month of Treatment With Zolpidem CR (Ambien®CR) in 6 Sites in Argentina Completed NCT01097382 Phase 4 ZOLPIDEM
23 Switching From Atripla to Stribild Leads to Improvements in Central Nervous System Side Effects and Sleep Disturbances Completed NCT02477527 Phase 4 Stribild
24 Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome With Major Depressive Disorder or Dysthymic Disorder Completed NCT00518986 Phase 4 armodafinil;placebo
25 Efficacy and Safety Assessment of ZOlpidem (Stilnox CR) Administered on as Needed Basis in Patients With Chronic insomNIA Completed NCT01024192 Phase 4 ZOLPIDEM SL800750
26 Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in ICD Patients Completed NCT00708786 Phase 4
27 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed NCT01234675 Phase 4 Milnacipran;Placebo
28 Randomized, Double-Blinded Clinical Trial to Evaluate the Incidence and Severity of Neuropsychiatric Side Effects and Antiviral Efficacy of Efavirenz Given as a Stepped Dosage Over 2 Weeks Versus the Usual Dosage in HIV-Infected Patients. Completed NCT00556634 Phase 4 Efavirenz
29 Paroxetine in the Treatment of Chronic Primary Insomnia: A Double-Blind, Randomized, Placebo-Controlled Study of Efficacy Over Six Weeks Completed NCT00178048 Phase 4 paroxetine
30 Behavioral and Pharmacological Treatment for Insomnia Completed NCT00042146 Phase 4 zolpidem
31 The Impact of Gastroesophageal Reflux Disease in Sleep Disorders: A Pilot Investigation of Rabeprazole, 20 mg Twice Daily for the Relief of GERD-Related Insomnia. Completed NCT00287391 Phase 4 Rabeprazole
32 An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue Completed NCT00678691 Phase 4 armodafinil;placebo
33 A Randomized Placebo-controlled Trial Evaluating the Effect of Melatonin on Sleep Quality in Patients With Dementia Completed NCT03066518 Phase 4 Melatonin 5 mg
34 Hydromorphone OROS in Korean Cancer Patients: Evaluation of Its Clinical Usefulness in Improvement of Sleep Disturbance Completed NCT00766831 Phase 4 Hydromorphone
35 Placebo Controlled Pilot Study on the Efficacy of Levocetirizine 5 mg in Reducing Symptoms, Airway Resistance, and Sleep Impairment in Patients With Persistent Allergic Rhinitis Completed NCT00355771 Phase 4 Levocetirizine;Placebo
36 Cognitive-Behavior Therapy for Insomnia: Component Analysis and Treatment Completed NCT00869934 Phase 4
37 Experimental Study of Mobile Base Station Related Radio-Frequency Electromagnetic Radiation in Healthy Adults and Adolescents Completed NCT00138905 Phase 4
38 Phase 4 Study of the Effects of Modafinil on Waking Function and on Sleep in Individuals With Primary Insomnia Completed NCT00124384 Phase 4 modafinil
39 A Single Dose, Open-Label, Randomized Two-Period Crossover Study in Healthy Young Subjects to Assess the Absolute Bioavailability of Tasimelteon (HETLIOZ™) Completed NCT02130999 Phase 4 tasimelteon 20 mg capsule;tasimelteon 2 mg I.V.
40 A Phase IV 3-Way Double-blind, Randomized, Crossover Study to Compare the Awakening Threshold Effects (Responsivity) of Belsomra 10 mg and 20 mg to Placebo in Non-elderly Insomniacs Completed NCT03312517 Phase 4 Suvorexant 10 mg;Suvorexant 20 mg;Placebo oral capsule
41 Efficacy and Safety of Eszopiclone (Lunesta) in Nursing Home Patients Completed NCT00460993 Phase 4 Lunesta
42 Progesterone Reduces Wakefulness in Sleep EEG and Has no Effect on Cognition in Healthy Postmenopausal Women Completed NCT00530582 Phase 4 progesterone
43 Eszopiclone and Inflammatory Mediators in Patients With Acute Coronary Syndrome Completed NCT00822679 Phase 4 Eszopiclone
44 Improving Sleep in Nursing Homes Completed NCT00576927 Phase 4 Ramelteon;Placebo
45 A Randomized, Double Blind, Study to Evaluate the Efficacy of Nasal Nicotine Spray to Reduce Post-Operative Opioid Requirements in Nonsmokers in Elective Laparoscopic Bariatric Surgical Patients Completed NCT01194089 Phase 4 Nasal Nicotine Spray;Nasal Normal Saline Spray
46 Impact of Smoking Cessation on Sleep Completed NCT00132821 Phase 4 Bupropion;Transdermal Nicotine Patch;Placebo Bupropion;Placebo transdermal nicotine patch
47 Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia Completed NCT03075657 Phase 4 Risperidone;Risperidone and Ramelteon;Haloperidol;Haloperidol and Ramelteon
48 Searching for "Sleep Friendly" Therapies for a Sleepy Population: A Double-Blind, Placebo-Controlled, Randomized Trial to Assess the Effects of Lacosamide on Sleep and Wake in Adults With Focal Epilepsy Completed NCT01190098 Phase 4 Lacosamide;Placebo
49 Sleep Apnea. Concordance Between Non-reference and Reference Centres Completed NCT00424658 Phase 4
50 Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil Completed NCT01965925 Phase 4 Modafinil;Placebo

Search NIH Clinical Center for Sleep Disorder

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Zolpidem tartrate

Genetic Tests for Sleep Disorder

Anatomical Context for Sleep Disorder

MalaCards organs/tissues related to Sleep Disorder:

Brain, Heart, Eye, Testes, Breast, Kidney, Lung

Publications for Sleep Disorder

Articles related to Sleep Disorder:

(show top 50) (show all 13213)
# Title Authors PMID Year
Effects of progressive muscle relaxation on anxiety and sleep quality in patients with COVID-19. 42
32379667 2020
Comparison between acupuncture and cognitive behavioral therapy for primary insomnia: A protocol for systematic review and network meta-analysis. 42
32481348 2020
Constructing gene network for type 1 narcolepsy based on genome-wide association study and differential gene expression analysis (STROBE). 42
32358372 2020
A survey of chronic pain in China. 61
32066339 2020
Recent advances in modulators of circadian rhythms: an update and perspective. 61
32506972 2020
Anxiety predicts dyadic sleep characteristics in couples experiencing insomnia but not in couples without sleep disorders. 61
32421592 2020
Metabolomics and proteomics profiles of some medicinal plants and correlation with BDNF activity. 61
30979692 2020
Sleep, premenstrual mood disorder, and women's health. 61
31610482 2020
Impact of childhood Dravet syndrome on care givers of patients with DS, a major impact on mothers. 61
32375095 2020
Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. 61
32437679 2020
Association between major depressive disorder and multiple disease outcomes: a phenome-wide Mendelian randomisation study in the UK Biobank. 61
31427754 2020
Brief digital sleep questionnaire powered by machine learning prediction models identifies common sleep disorders. 61
32502852 2020
Behavioral phenotype and sleep problems in SATB2-associated syndrome. 61
31420882 2020
Clinical analysis of anti-NMDAR encephalitis combined with MOG antibody in children. 61
32234601 2020
Cytokines in narcolepsy: A systematic review and meta-analysis. 61
32315956 2020
Repetitive TMS for sleep disorders: are we ready? 61
32386885 2020
Social timing influences sleep quality in patients with sleep disorders. 61
32460138 2020
The mutagenic effect of psychostimulant modafinil in Wistar rats in vivo. 61
30293447 2020
The Humanistic and Economic Burden of Pediatric Focal Seizures in the United States. 61
32223583 2020
EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke. 61
32314498 2020
Dietary natural cocoa ameliorates disrupted circadian rhythms in locomotor activity and sleep-wake cycles in mice with chronic sleep disorders caused by psychophysiological stress. 61
32247223 2020
The influence of sleep quality on the development of periocular hyperchromia: a case-control study. 61
31663247 2020
Potential use of actigraphy to measure sleep in monkeys: comparison with behavioral analysis from videography. 61
32400976 2020
Clinical implication of high-density EEG sleep recordings in Parkinson's disease. 61
32330466 2020
Modafinil reduces choice impulsivity while increasing motor activity in preadolescent rats treated prenatally with alcohol. 61
32360693 2020
Effects of exercise on sleep in neurodegenerative disease. 61
32243913 2020
Effects of repetitive transcranial magnetic stimulation in subjects with sleep disorders. 61
32173186 2020
Night shift work in resident physicians: does it affect mood states and cognitive levels? 61
32553370 2020
Association of socioeconomic factors and prevalence of hypertension with sleep disorder among the elderly in rural southwest China. 61
32505023 2020
Advances in pathophysiology and neuroimaging: Implications for sleep and dementia. 61
31726479 2020
[Circadian rhythm sleep disorders: clinical picture, diagnosis and treatment]. 61
32558452 2020
[Comparative analysis of serum glutamate and gamma-aminobutyric acid levels in patients with bipolar depressive disorder and major depression disorder]. 61
32536126 2020
Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HT2B Receptors and Triggers Depressive-Like Behaviors via Stimulating P2X7 Receptors in Mice. 61
32506374 2020
Sleep disorders in migrants and refugees: a systematic review with implications for personalized medical approach. 61
32549917 2020
Comorbid psychiatric disorders among patients with narcolepsy. 61
31280401 2020
Use of Recorded Poetic Audios to Manage Levels of Anxiety and Sleep Disorders. 61
31696376 2020
Sleep in the Aging Population. 61
32386704 2020
A review of the incidence and risk factors for fibromyalgia and chronic widespread pain in population-based studies. 61
32040078 2020
Efficacy of an m-Health Physical Activity and Sleep Intervention to Improve Sleep Quality in Middle-Aged Adults: The Refresh Study Randomized Controlled Trial. 61
31942918 2020
Sleep disturbance and depression in adolescence: an integrative review of literature. 61
32549166 2020
Effect of Huatan Jieyu granules in treatment of Parkinson's disease patients with sleep disorder identified as symptom pattern of phlegma-heat-stirring wind. 61
32506861 2020
Physiological and pharmacological perspectives of melatonin. 61
32520581 2020
Narcolepsy treatment: pharmacological and behavioral strategies in adults and children. 61
31290083 2020
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Variations for Sleep Disorder

Expression for Sleep Disorder

Search GEO for disease gene expression data for Sleep Disorder.

Pathways for Sleep Disorder

GO Terms for Sleep Disorder

Cellular components related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.17 TFAP2B MAPT HCRTR2 HCRTR1 HCRT GHRL
2 axolemma GO:0030673 8.96 MAPT ADORA1

Biological processes related to Sleep Disorder according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.22 PRL LEP INS HCRTR2 HCRTR1 GHRL
2 G protein-coupled receptor signaling pathway GO:0007186 10.1 NPS INS HCRTR2 HCRTR1 HCRT GHRL
3 rhythmic process GO:0048511 9.81 PER3 PER2 CRY1 ARNTL
4 glucose homeostasis GO:0042593 9.78 TFAP2B LEP INS CRY1
5 response to nutrient levels GO:0031667 9.75 PRL LEP GHRL
6 excitatory postsynaptic potential GO:0060079 9.72 HCRT GHRL ADORA1
7 neuropeptide signaling pathway GO:0007218 9.71 NPS HCRTR2 HCRTR1 HCRT
8 feeding behavior GO:0007631 9.67 HCRTR2 HCRTR1 HCRT
9 positive regulation of cold-induced thermogenesis GO:0120162 9.67 PER2 LEP HCRT GHRL
10 entrainment of circadian clock by photoperiod GO:0043153 9.63 PER3 PER2 CRY1
11 fatty acid homeostasis GO:0055089 9.62 INS ADORA1
12 regulation of insulin secretion GO:0050796 9.62 TFAP2B PER2 LEP ARNTL
13 negative regulation of lipid catabolic process GO:0050995 9.61 INS ADORA1
14 central nervous system neuron development GO:0021954 9.61 MAPT LEP
15 response to light stimulus GO:0009416 9.61 PER3 PER2 CRY1
16 adult feeding behavior GO:0008343 9.6 LEP GHRL
17 negative regulation of circadian rhythm GO:0042754 9.59 PER2 CRY1
18 negative regulation of lipid storage GO:0010888 9.58 LEP CRP
19 negative regulation of acute inflammatory response GO:0002674 9.57 INS ADORA1
20 circadian regulation of gene expression GO:0032922 9.56 PER3 PER2 CRY1 ARNTL
21 magnesium ion homeostasis GO:0010960 9.54 TFAP2B ANK3
22 negative regulation of glucocorticoid receptor signaling pathway GO:2000323 9.52 CRY1 ARNTL
23 glucose metabolic process GO:0006006 9.46 TFAP2B LEP INS GHRL
24 negative regulation of blood vessel diameter GO:0097756 9.13 INS CRP ADORA1
25 circadian rhythm GO:0007623 9.02 PER3 PER2 LEP CRY1 ARNTL

Molecular functions related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.26 PRL LEP INS GHRL
2 transcription corepressor binding GO:0001222 9.16 PER3 PER2
3 orexin receptor activity GO:0016499 8.62 HCRTR2 HCRTR1

Sources for Sleep Disorder

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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