MCID: SLP010
MIFTS: 37

Slipped Capital Femoral Epiphysis

Categories: Rare diseases

Aliases & Classifications for Slipped Capital Femoral Epiphysis

MalaCards integrated aliases for Slipped Capital Femoral Epiphysis:

Name: Slipped Capital Femoral Epiphysis 53
Slipped Capital Femoral Epiphyses 73

Classifications:



External Ids:

UMLS 73 C0149887

Summaries for Slipped Capital Femoral Epiphysis

MalaCards based summary : Slipped Capital Femoral Epiphysis, also known as slipped capital femoral epiphyses, is related to hypothyroidism and turner syndrome. An important gene associated with Slipped Capital Femoral Epiphysis is NPR2 (Natriuretic Peptide Receptor 2), and among its related pathways/superpathways are Development IGF-1 receptor signaling and DNA Damage Response. The drugs Methyclothiazide and Gentamicins have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and kidney, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : 76 Slipped capital femoral epiphysis (SCFE or skiffy, slipped upper femoral epiphysis, SUFE or souffy, coxa... more...

Related Diseases for Slipped Capital Femoral Epiphysis

Diseases related to Slipped Capital Femoral Epiphysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 hypothyroidism 31.0 IGF1 IGFBP3
2 turner syndrome 30.6 IGF1 IGFBP3
3 growth hormone deficiency 30.5 IGF1 IGFBP3
4 hypopituitarism 30.2 IGF1 IGFBP3
5 silver-russell syndrome 30.2 IGF1 IGFBP3
6 prader-willi syndrome 30.1 IGF1 IGFBP3
7 epiphysiolysis of the hip 12.2
8 legg-calve-perthes disease 11.9
9 epiphyseal chondrodysplasia, miura type 11.6
10 osteonecrosis 10.7
11 hyperparathyroidism 10.7
12 body mass index quantitative trait locus 1 10.6
13 osteoarthritis 10.6
14 renal osteodystrophy 10.6
15 primary hyperparathyroidism 10.6
16 down syndrome 10.5
17 avascular necrosis of femoral head, primary, 1 10.5
18 arthritis 10.5
19 osteopetrosis 10.5
20 gigantism 10.5
21 coxa vara 10.4
22 chromosome 16p13.3 deletion syndrome, proximal 10.4
23 pseudohypoparathyroidism 10.4
24 precocious puberty 10.4
25 hypomagnesemia 3, renal 10.2
26 pycnodysostosis 10.2
27 spastic paraplegia 17, autosomal dominant 10.2
28 body mass index quantitative trait locus 11 10.2
29 growth hormone insensitivity, partial 10.2
30 body mass index quantitative trait locus 10 10.2
31 parathyroid carcinoma 10.2
32 body mass index quantitative trait locus 14 10.2
33 body mass index quantitative trait locus 18 10.2
34 body mass index quantitative trait locus 19 10.2
35 cerebral palsy 10.2
36 congenital hypothyroidism 10.2
37 scoliosis 10.2
38 bone disease 10.2
39 hypogonadotropic hypogonadism 10.2
40 rickets 10.2
41 nephrocalcinosis 10.2
42 blount's disease 10.2
43 hypogonadism 10.2
44 rhabdomyosarcoma 10.2
45 craniopharyngioma 10.2
46 pituitary hypoplasia 10.2
47 hypogonadotropism 10.2
48 septic arthritis 10.2
49 intracranial hypertension 10.2
50 sickle cell disease 10.2

Graphical network of the top 20 diseases related to Slipped Capital Femoral Epiphysis:



Diseases related to Slipped Capital Femoral Epiphysis

Symptoms & Phenotypes for Slipped Capital Femoral Epiphysis

MGI Mouse Phenotypes related to Slipped Capital Femoral Epiphysis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.33 IGF1 IGFBP3 NPR2
2 muscle MP:0005369 9.13 IGF1 IGFBP3 NPR2
3 respiratory system MP:0005388 8.8 IGF1 IGFBP3 NPR2

Drugs & Therapeutics for Slipped Capital Femoral Epiphysis

Drugs for Slipped Capital Femoral Epiphysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyclothiazide Approved Phase 4 135-07-9 4121
2 Gentamicins Phase 4
3 Anti-Bacterial Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Sodium Chloride Symporter Inhibitors Phase 4
6 diuretics Phase 4
7 Natriuretic Agents Phase 4
8 Hormones Phase 4
9 Hormone Antagonists Phase 4
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
11
Pamidronate Approved Not Applicable 40391-99-9 4674
12 Diphosphonates Not Applicable
13 Bone Density Conservation Agents Not Applicable

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Study to Assess the Long-term Performance of SmartSet® HV and SmartSet® GHV Bone Cements in Primary Total Hip Replacement Completed NCT00872066 Phase 4
2 A Randomised Single Centre Study to Compare the Long-term Wear Characteristics of Marathon™ and Enduron™ Polyethylene Cup Liners in Primary Total Hip Replacement Completed NCT00208442 Phase 4
3 Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome Completed NCT00266656 Phase 4 Humatrope
4 A Randomised Study to Compare Metal Ion Release and Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-Metal or a Metal-on-Metal Bearing Terminated NCT00873444 Phase 4
5 A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery Terminated NCT00872794 Phase 4
6 A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stem™ AMT in a Total Primary Hip Replacement Terminated NCT00872573 Phase 4
7 Multi-Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Resurfacing and Primary Total Hip Replacement Terminated NCT00872547 Phase 4
8 A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement Terminated NCT00872222 Phase 4
9 A Multi-centre Study to Assess the Long-term Performance of the Summit™ Hip in Primary Total Hip Replacement Terminated NCT00208390 Phase 4
10 A Multi-centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery Terminated NCT00208377 Phase 4
11 A Two Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Metal-on-Metal Bearing in Primary Total Hip Replacement Terminated NCT00208364 Phase 4
12 A Multi-centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Polyethylene-on-metal Bearing in Primary Total Hip Replacement Withdrawn NCT00208429 Phase 4
13 A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement Terminated NCT00208468 Phase 3
14 A Randomised Single Centre Study to Compare the Long-term Performance of 4 Designs of the DePuy Ultima LX Stem in Primary Total Hip Replacement Terminated NCT00208351 Phase 3
15 Evaluation of Skeletal Maturity for Slipped Capital Femoral Epiphysis Unknown status NCT01220882 Not Applicable
16 "Gait and Balance in Patients With SCFE" Recruiting NCT03326531
17 Slipped Capital Femoral Epiphysis Treatment Not yet recruiting NCT03229590
18 The Use of Bisphosphonates in the Treatment of Avascular Necrosis of the Femoral Head Terminated NCT02007915 Not Applicable Pamidronate Disodium

Search NIH Clinical Center for Slipped Capital Femoral Epiphysis

Genetic Tests for Slipped Capital Femoral Epiphysis

Anatomical Context for Slipped Capital Femoral Epiphysis

MalaCards organs/tissues related to Slipped Capital Femoral Epiphysis:

41
Bone, Testes, Kidney, Pituitary, Eye, Thyroid, Pineal

Publications for Slipped Capital Femoral Epiphysis

Articles related to Slipped Capital Femoral Epiphysis:

(show top 50) (show all 951)
# Title Authors Year
1
Incremental Value of SPECT/CT in the Detection of Femoral Head Viability in Slipped Capital Femoral Epiphysis. ( 29438004 )
2018
2
Diagnosing slipped capital femoral epiphysis amongst various medical specialists. ( 29707055 )
2018
3
Slipped Capital Femoral Epiphysis: The European Perspective. ( 29877936 )
2018
4
Diagnosis and treatment of slipped capital femoral epiphysis: Recent trends to note. ( 29361376 )
2018
5
Comparison between modified Dunn procedure and in situ fixation for severe stable slipped capital femoral epiphysis. ( 29451057 )
2018
6
The reliability of radiostereometric analysis in determining physeal motion in slipped capital femoral epiphysis in standard uniplanar and low-dose EOS biplanar radiography: a phantom model study. ( 29762188 )
2018
7
CORR InsightsAr: Morphologic Features of the Contralateral Femur in Patients With Unilateral Slipped Capital Femoral Epiphysis Resembles Mild Slip Deformity: A Matched Cohort Study. ( 29481357 )
2018
8
The modified Dunn procedure provides superior short-term outcomes in the treatment of the unstable slipped capital femoral epiphysis as compared to the inadvertent closed reduction and percutaneous pinning: a comparative clinical study. ( 29797165 )
2018
9
Increased time between diagnosis and surgery in slipped capital femoral epiphysis results in increased radiographic deformity. ( 29951122 )
2018
10
Persisting CAM deformity is associated with early cartilage degeneration after Slipped Capital Femoral Epiphysis: 11-year follow-up including dGEMRIC. ( 29426010 )
2018
11
The Peritubercle Lucency Sign is a Common and Early Radiographic Finding in Slipped Capital Femoral Epiphysis. ( 29889771 )
2018
12
Valgus Slipped Capital Femoral Epiphysis: Pathophysiology of Motion and Results of Intracapsular Realignment. ( 29373445 )
2018
13
Surgical treatment of femoroacetabular impingement after slipped capital femoral epiphysis. ( 29206650 )
2018
14
Obesity-related metabolic and endocrine disorders diagnosed during postoperative follow-up of slipped capital femoral epiphysis. ( 29521181 )
2018
15
The S Sign: A New Radiographic Tool to Aid in the Diagnosis of Slipped Capital Femoral Epiphysis. ( 29550284 )
2018
16
Morphologic Features of the Contralateral Femur in Patients With Unilateral Slipped Capital Femoral Epiphysis Resembles Mild Slip Deformity: A Matched Cohort Study. ( 29481345 )
2018
17
Femoral pseudoaneurysm as a complication of slipped capital femoral epiphysis treatment. ( 29367918 )
2018
18
Intracapsular cuneiform osteotomy compared with in-situ pinning for the management of slipped capital femoral epiphysis. ( 29878978 )
2018
19
Xanthomatous hypophysitis causing hypogonadotropic hypogonadism resulting in delayed presentation of slipped capital femoral epiphysis. ( 30450996 )
2018
20
Pediatric Hip Disorders: Slipped Capital Femoral Epiphysis and Legg-Calvé-Perthes Disease. ( 30171056 )
2018
21
Osteonecrosis After Contralateral in Situ Prophylactic Pinning for a Slipped Capital Femoral Epiphysis: A Case Report. ( 30095469 )
2018
22
Similar femoral growth and deformity with one screw versus two smooth pins for slipped capital femoral epiphysis. ( 30039196 )
2018
23
Moderate and severe SCFE (Slipped Capital Femoral Epiphysis) arthroscopic osteoplasty vs open neck osteotomy-a retrospective analysis of results. ( 30135982 )
2018
24
Epidemiology of Slipped Capital Femoral Epiphysis in Ontario, Canada. ( 30199462 )
2018
25
Slipped Capital Femoral Epiphysis: A Review for Pediatricians. ( 30208198 )
2018
26
The Epidemiology of Slipped Capital Femoral Epiphysis in American Samoa. ( 30221075 )
2018
27
Trends in slipped capital femoral epiphysis: is the rate declining? ( 30294366 )
2018
28
Outcomes after slipped capital femoral epiphysis: a population-based study with three-year follow-up. ( 30294367 )
2018
29
Acetabular morphology in slipped capital femoral epiphysis: comparison at treatment onset and skeletal maturity. ( 30294368 )
2018
30
MRI in idiopathic, stable, slipped capital femoral epiphysis: evaluation of contralateral pre-slip. ( 30294369 )
2018
31
Childhood Obesity and Slipped Capital Femoral Epiphysis. ( 30348751 )
2018
32
The results of osteotomy at the base of femoral neck with osteoplasty in restoration of abductor function and strength in slipped capital femoral epiphysis. ( 30418052 )
2018
33
Patterns of Pain in Adolescents with Slipped Capital Femoral Epiphysis. ( 30454962 )
2018
34
Avascular necrosis post unstable slipped capital femoral epiphysis: a treatment algorithm with staged hinged hip distraction: mid-term results. ( 30456991 )
2018
35
What Is the Prevalence of Cam Deformity After Prophylactic Pinning of the Contralateral Asymptomatic Hip in Unilateral Slipped Capital Femoral Epiphysis? A 10-year Minimum Followup Study. ( 30550402 )
2018
36
Suprasellar Germinoma Presenting with Slipped Capital Femoral Epiphysis: Case Report. ( 29487768 )
2017
37
Asynchronous slipped capital femoral epiphysis in a patient with a seizure disorder: case report and review of the literature. ( 28657919 )
2017
38
Residual Femoral Deformity and Femoroacetabular Impingement after Intertrochanteric Osteotomy for Slipped Capital Femoral Epiphysis. ( 28824187 )
2017
39
Femoral and acetabular re-alignment in slipped capital femoral epiphysis. ( 28529662 )
2017
40
Outcome of pinning in patients with slipped capital femoral epiphysis: risk factors associated with avascular necrosis, chondrolysis, and femoral impingement. ( 29210310 )
2017
41
3-dimensional metrics of proximal femoral shape deformities in Legg-CalvAc-Perthes disease and slipped capital femoral epiphysis. ( 29087625 )
2017
42
Treatment of stable slipped capital femoral epiphysis: systematic review and exploratory patient level analysis. ( 28831651 )
2017
43
Special symposium issue: slipped capital femoral epiphysis (SCFE). ( 28529653 )
2017
44
Treatment of chronic, stable slipped capital femoral epiphysis via surgical hip dislocation with combined osteochondroplasty and Imhauser osteotomy. ( 28904634 )
2017
45
The modified Dunn procedure for slipped capital femoral epiphysis: the Bernese experience. ( 28529663 )
2017
46
Opinion survey of members of British Society of Children's Orthopaedic Surgery related to specific case scenarios in slipped capital femoral epiphysis. ( 28079739 )
2017
47
Slipped capital femoral epiphysis in children younger than 10 years old: clinical characteristics and efficacy of physeal-sparing procedures. ( 28704299 )
2017
48
Biomechanical Evaluation of the Depth of Resection During Femoral Neck Osteoplasty for Anterior Impingement Following Slipped Capital Femoral Epiphysis. ( 28244926 )
2017
49
A nationwide cohort study of slipped capital femoral epiphysis. ( 28663349 )
2017
50
Slipped capital femoral epiphysis management and the arthroscope. ( 28529661 )
2017

Variations for Slipped Capital Femoral Epiphysis

Expression for Slipped Capital Femoral Epiphysis

Search GEO for disease gene expression data for Slipped Capital Femoral Epiphysis.

Pathways for Slipped Capital Femoral Epiphysis

GO Terms for Slipped Capital Femoral Epiphysis

Cellular components related to Slipped Capital Femoral Epiphysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
2 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Slipped Capital Femoral Epiphysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.16 IGF1 IGFBP3
2 positive regulation of MAPK cascade GO:0043410 8.96 IGF1 IGFBP3
3 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.62 IGF1 IGFBP3

Sources for Slipped Capital Femoral Epiphysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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