SCFE
MCID: SLP010
MIFTS: 39

Slipped Capital Femoral Epiphysis (SCFE)

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Slipped Capital Femoral Epiphysis

MalaCards integrated aliases for Slipped Capital Femoral Epiphysis:

Name: Slipped Capital Femoral Epiphysis 52 58
Slipped Upper Femoral Epiphysis 52 58 32
Epiphysiolysis of the Upper Femur 52 58
Femoral Head Epiphysiolysis 52 58
Epiphysiolysis of the Hip 52 58
Scfe 52 58
Sufe 52 58
Slipped Capital Femoral Epiphysis. 52
Slipped Capital Femoral Epiphyses 71

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

ICD10 32 M93.0
ICD10 via Orphanet 33 M93.9
Orphanet 58 ORPHA399329
UMLS 71 C0149887

Summaries for Slipped Capital Femoral Epiphysis

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 399329 Definition Epiphysiolysis of the hip is a rare osteonecrosis disorder characterized by unilateral or bilateral disruption of the capital femoral physis with varying degrees of posterior epiphysis translation and simultaneous anterior metaphysis displacement. Patients typically present in pre-adolescence/adolescence with pain of variable intensity in varying locations (hip, groin, thigh, knee). Visit the Orphanet disease page for more resources.

MalaCards based summary : Slipped Capital Femoral Epiphysis, also known as slipped upper femoral epiphysis, is related to hypopituitarism and turner syndrome. An important gene associated with Slipped Capital Femoral Epiphysis is NPR2 (Natriuretic Peptide Receptor 2), and among its related pathways/superpathways are Development IGF-1 receptor signaling and DNA Damage Response. The drugs Gentamicins and Sodium Chloride Symporter Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and kidney, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : 74 Slipped capital femoral epiphysis (SCFE or skiffy, slipped upper femoral epiphysis, SUFE or souffy, coxa... more...

Related Diseases for Slipped Capital Femoral Epiphysis

Diseases related to Slipped Capital Femoral Epiphysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Related Disease Score Top Affiliating Genes
1 hypopituitarism 30.6 IGFBP3 IGF1
2 turner syndrome 30.5 IGFBP3 IGF1
3 cerebral palsy 30.1 IGFBP3 IGF1
4 pituitary gland disease 30.0 IGFBP3 IGF1
5 insulin-like growth factor i 30.0 IGFBP3 IGF1
6 congenital hypothyroidism 30.0 IGFBP3 IGF1
7 hyperinsulinism 29.9 IGFBP3 IGF1
8 glucose intolerance 29.8 IGFBP3 IGF1
9 prader-willi syndrome 29.6 IGFBP3 IGF1
10 legg-calve-perthes disease 12.1
11 epiphyseal chondrodysplasia, miura type 11.8
12 avascular necrosis 11.4
13 slipped femoral capital epiphyses 11.2
14 osteonecrosis 11.1
15 hypothyroidism 11.1
16 osteoarthritis 10.9
17 hyperparathyroidism 10.8
18 hypogonadism 10.8
19 coxa vara 10.8
20 pituitary hormone deficiency, combined, 2 10.8
21 body mass index quantitative trait locus 1 10.8
22 primary hyperparathyroidism 10.8
23 renal osteodystrophy 10.7
24 blount's disease 10.7
25 growth hormone deficiency 10.7
26 overgrowth syndrome 10.7
27 rickets 10.7
28 plica syndrome 10.7
29 synovitis 10.7
30 gonadal dysgenesis 10.6
31 adenoma 10.6
32 parathyroid adenoma 10.6
33 down syndrome 10.6
34 bone disease 10.6
35 chondromalacia 10.6
36 craniopharyngioma 10.6
37 gigantism 10.6
38 body mass index quantitative trait locus 11 10.5
39 body mass index quantitative trait locus 9 10.5
40 body mass index quantitative trait locus 8 10.5
41 body mass index quantitative trait locus 4 10.5
42 body mass index quantitative trait locus 10 10.5
43 body mass index quantitative trait locus 7 10.5
44 body mass index quantitative trait locus 12 10.5
45 body mass index quantitative trait locus 14 10.5
46 body mass index quantitative trait locus 18 10.5
47 body mass index quantitative trait locus 19 10.5
48 body mass index quantitative trait locus 20 10.5
49 scoliosis 10.5
50 osteopetrosis 10.5

Graphical network of the top 20 diseases related to Slipped Capital Femoral Epiphysis:



Diseases related to Slipped Capital Femoral Epiphysis

Symptoms & Phenotypes for Slipped Capital Femoral Epiphysis

MGI Mouse Phenotypes related to Slipped Capital Femoral Epiphysis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.13 IGF1 IGFBP3 NPR2
2 muscle MP:0005369 8.8 IGF1 IGFBP3 NPR2

Drugs & Therapeutics for Slipped Capital Femoral Epiphysis

Drugs for Slipped Capital Femoral Epiphysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Gentamicins Phase 4
2 Sodium Chloride Symporter Inhibitors Phase 4
3 diuretics Phase 4
4 Hormone Antagonists Phase 4
5 Hormones Phase 4
6
Pamidronate Approved 40391-99-9 4674
7 Diphosphonates

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomised, Uncontrolled, Single-Centre, Post-Market Surveillance Study To Evaluate The Performance Of SmartSet® HV and SmartSet® GHV Bone Cements In Primary Cemented Total Hip Arthroplasty(THA) Completed NCT00872066 Phase 4
2 A Prospective, Randomised, Controlled, Single Centre, Blinded Study of the Wear Characteristics of Two Polyethylene Bearing Surfaces, Enduron vs. Marathon Completed NCT00208442 Phase 4
3 Prospective, Uncontrolled, Multi-Centre, Post-Marketing Surveillance Study to Evaluate the Long-Term Performance of Summit Tapered Hip in Cementless Total Hip Arthroplasty Terminated NCT00208390 Phase 4
4 Prospective, Uncontrolled, Two-centre, RSA, Post-market Surveillance Study to Evaluate the Stability of the C-Stem™ AMT Femoral Component in Primary Total Hip Arthroplasty. Terminated NCT00872573 Phase 4
5 Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle™ Acetabular Cup Prosthesis With a Ceramic-on-ceramic Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement Terminated NCT00872222 Phase 4
6 Randomised, Controlled, Prospective, Multi-Centre, Post Market Surveillance Study Comparing a Ceramic-on-Metal Bearing and a Metal-on-Metal Bearing in Subjects Requiring Primary Total Hip Arthroplasty for Non-Inflammatory Degenerative Joint Disease Terminated NCT00873444 Phase 4
7 Prospective Single-centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-term Performance of the DePuy ASR™ Hip in Subjects With Suitable Indications for a Primary Resurfacing Hip Arthroplasty Terminated NCT00872794 Phase 4
8 Prospective, International Multi-centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-term Performance of a Large Metal-on-Metal (MoM) Bearing Comprising a DePuy ASR™ Cup in Conjunction With Either a DePuy ASR™ Hip Resurfacing Femoral Component or a DePuy ASR™ XL Head in Subjects With Indications Suitable for Either a Primary Resurfacing Arthroplasty or Primary Total Hip Arthroplasty Terminated NCT00872547 Phase 4
9 Prospective Multi-Centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-Term Performance of the DePuy ASR Hip System in Subjects With Suitable Indications for a Primary Resurfacing Hip Arthroplasty Terminated NCT00208377 Phase 4
10 Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle Acetabular Cup Prosthesis With a Metal on Metal Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement Terminated NCT00208364 Phase 4
11 A Multicenter Study of the Effect of Recombinant Human Growth Hormone on Leptin and Cytokines in Relation to Body Composition in Pediatric Patients With Growth Failure Due to Chronic Kidney Disease (CKD) Terminated NCT00194961 Phase 4 Recombinant Human Growth Hormone
12 Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle Acetabular Cup System With a Metal on Enduron Polyethylene Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement Withdrawn NCT00208429 Phase 4
13 A Multi-centre, Randomised, Parallel Group, Controlled Study to Compare the Performance of the Future Hip Against Three Currently Used Implants in Total Hip Replacement Terminated NCT00208468 Phase 3
14 Clinical and Radiographic Evaluation to Compare a Polished and Non-polished Collared Stem and a Polished and Non Polished Collarless Stem in Primary Total Hip Replacement Terminated NCT00208351 Phase 3
15 Skeletal Age Assessment From the Olecranon For Slipped Capital Femoral Epiphysis Unknown status NCT01220882
16 The Effect of Somatic Dysfunction of the Pelvis, Sacrum and Lower Lumbar Spine on Weight Bearing Completed NCT01097109
17 Study on the Diagnostic Qualities of the Positron Emission Tomography Coupled to the Scanner (PET / CT) in the Assessment of Response to Non-Hodgkin's Lymphoma Therapy in Children and Adolescents Completed NCT02488369
18 SLIP Registry - SCFE Longitudinal International Prospective Registry Recruiting NCT04117841
19 Slipped Capital Femoral Epiphysis; Changes in Gait, Balance and Muscle Activity Patterns in Patients Treated With Single Screw in Situ Fixation Investigated Using Computer Assisted Rehabilitation ENvironment (CAREN) Recruiting NCT03326531
20 Intraoperative Monitoring of Femoral Head Perfusion in Femoral Neck Fractures Enrolling by invitation NCT04110639
21 Safe Surgical Dislocation in Slipped Capital Femoral Epiphysis Not yet recruiting NCT03229590
22 Prospective Randomized Controlled Study Utilizing the Stryker Hip-Check Software Platform Not yet recruiting NCT04265222
23 The Use of Bisphosphonates in the Treatment of Avascular Necrosis of the Femoral Head Terminated NCT02007915 Pamidronate Disodium

Search NIH Clinical Center for Slipped Capital Femoral Epiphysis

Genetic Tests for Slipped Capital Femoral Epiphysis

Anatomical Context for Slipped Capital Femoral Epiphysis

MalaCards organs/tissues related to Slipped Capital Femoral Epiphysis:

40
Bone, Testes, Kidney, Pituitary, Thyroid, Bone Marrow, Eye

Publications for Slipped Capital Femoral Epiphysis

Articles related to Slipped Capital Femoral Epiphysis:

(show top 50) (show all 1568)
# Title Authors PMID Year
1
Risk Factors for Contralateral Slipped Capital Femoral Epiphysis: A Meta-analysis of Cohort and Case-control Studies. 61
32501913 2020
2
Valgus slipped capital femoral epiphysis: a systematic review. 61
32558777 2020
3
Quantitative Evaluation of Hip Muscle Atrophy in Patients with Unilateral Slipped Capital Femoral Epiphysis Based on Magnetic Resonance Imaging. 61
32540199 2020
4
Consensus recommendations on the classification, definition and diagnostic criteria of hip-related pain in young and middle-aged active adults from the International Hip-related Pain Research Network, Zurich 2018. 61
31959678 2020
5
The point of epiphyseal penetration affects rotational stability of screw fixation in slipped capital femoral epiphysis: A biomechanical study. 61
32427362 2020
6
Patients' delay is the major cause for late diagnosis of slipped capital femoral epiphysis. 61
32371650 2020
7
Evaluation of the Three-Dimensional Translational and Angular Deformity in Slipped Capital Femoral Epiphysis. 61
31793021 2020
8
Slipped Capital Femoral Epiphysis: A Review of the New Zealand Literature. 61
32453109 2020
9
Predicting Growth Quantitatively Through Proximal Tibia Radiograph Markers. 61
32404656 2020
10
Femoral head fracture similar to slipped capital femoral epiphysis in an elderly woman with antecedent hip osteoarthritis after subchondral insufficiency fracture: A case report. 61
28967534 2020
11
CORR Insights®: What is the Accuracy and Reliability of the Peritubercle Lucency Sign on Radiographs for Early Diagnosis of Slipped Capital Femoral Epiphysis Compared With MRI as the Gold Standard? 61
32217861 2020
12
Normative Values for Capital Femoral Epiphyseal Extension of the Developing Hip Based on Age, Sex, and Oxford Bone Age. 61
31821249 2020
13
Contralateral slip after unilateral slipped capital femoral epiphysis is associated with acetabular retroversion but not increased acetabular depth and overcoverage. 61
31305365 2020
14
Intertrochanteric Imhäuser osteotomy combined with osteochondroplasty in treatment of moderate-severe stable slipped capital femoral epiphysis: a case series study. 61
31651754 2020
15
What Is the Accuracy and Reliability of the Peritubercle Lucency Sign on Radiographs for Early Diagnosis of Slipped Capital Femoral Epiphysis Compared With MRI as the Gold Standard? 61
31977443 2020
16
Effect of seasonal variation on the peak presentation of slipped capital femoral epiphysis. A comparison of children in Johannesburg, South Africa and London, UK. 61
31688335 2020
17
Fate of patients with slipped capital femoral epiphysis (SCFE) in later life: risk of obesity, hypothyroidism, and death in 2,564 patients with SCFE compared with 25,638 controls. 61
32285743 2020
18
The Role of Hyperinsulinemia in Slipped Capital Femoral Epiphysis. 61
32251114 2020
19
Primary hyperparathyroidism presenting as slipped capital femoral epiphysis. 61
31615926 2020
20
The characteristics of the whole pelvic morphology in slipped capital femoral epiphysis: A retrospective observational study. 61
32243382 2020
21
Predicting subsequent contralateral slipped capital femoral epiphysis: an evidence-based approach. 61
32351620 2020
22
Valgus slipped capital femoral epiphysis: presentation, treatment, and clinical outcomes using patient-reported measurements. 61
32301822 2020
23
Causes of Delayed Diagnosis of Slipped Capital Femoral Epiphysis: The Importance of the Frog Lateral Pelvis Projection. 61
32431996 2020
24
The Outside-In Technique for Slipped Capital Femoral Epiphysis: A Safe and Reproducible Approach in Hip Arthroscopy. 61
32368469 2020
25
Surgical treatment of symptomatic post-slipped capital femoral epiphysis deformity: a comparative study between hip arthroscopy and surgical hip dislocation with or without intertrochanteric osteotomy. 61
32351621 2020
26
Pelvic Bone Deformity and Its Correlation with Acetabular Center-edge Angle. 61
32346202 2020
27
Increased Hip Intracapsular Pressure Decreases Perfusion of the Capital Femoral Epiphysis in a Skeletally Immature Porcine Model. 61
32132447 2020
28
Slipped Capital Femoral Epiphysis in Children without Obesity. 61
31955882 2020
29
Application of functional data analysis to explore movements: walking, running and jumping - A systematic review. 61
32058281 2020
30
The Atypical Patient With Slipped Capital Femoral Epiphyses May Be at Increased Risk for a Missed Contralateral Slip. 61
31930409 2020
31
Functional Outcomes of Hip Arthroscopy for Pediatric and Adolescent Hip Disorders. 61
32117544 2020
32
Salvage of failed in-situ pinning in severe unstable slipped capital femoral physis by surgical dislocation and capital realignment. 61
32099283 2020
33
Proximal Femoral Deformity Following Threaded Prophylactic Fixation for Slipped Capital Femoral Epiphysis: Risk Stratification Using the Modified Oxford Score. 61
32218015 2020
34
Pediatric Hip and Pelvis. 61
31779829 2020
35
Pediatric Anesthesia Concerns and Management for Orthopedic Procedures. 61
31779838 2020
36
Capital Femoral Epiphyseal Cupping and Extension May Be Protective in Slipped Capital Femoral Epiphysis: A Dual-Center Matching Cohort Study. 61
32040063 2020
37
Predicting epiphyseal stability of slipped capital femoral epiphysis with preoperative CT imaging. 61
32165983 2020
38
Factors Affecting Outcomes of Slipped Capital Femoral Epiphysis. 61
32190446 2020
39
A novel surgical navigation technology for placement of implants in slipped capital femoral epiphysis. 61
31875353 2020
40
Moon (or Eid) Crescent Sign of the Femoral Head. 61
32181099 2020
41
Age- and sex-specific morphologic changes in the metaphyseal fossa adjacent to epiphyseal tubercle in children and adolescents without hip disorders. 61
32091139 2020
42
Treatment for Post-Slipped Capital Femoral Epiphysis Deformity. 61
31739878 2020
43
Vascular Supply to the Femoral Head in Patients With Healed Slipped Capital Femoral Epiphysis. 61
30969198 2020
44
Slipped capital femoral epiphysis after treatment of femoral neck fracture. 61
31933615 2020
45
Hip Pain in Children. 61
32070474 2020
46
Smaller Epiphyseal Tubercle and Larger Peripheral Cupping in Slipped Capital Femoral Epiphysis Compared with Healthy Hips: A 3-Dimensional Computed Tomography Study. 61
31596801 2020
47
Total Hip Arthroplasty for Secondary Causes of Arthritis An Increase in Time and Money. 61
31785135 2019
48
Orthopaedic Manifestations in Turner Syndrome. 61
31567543 2019
49
Radiation-free methods for navigated screw placement in slipped capital femoral epiphysis surgery. 61
31321601 2019
50
Alpha Angle as a Predictor of Impending Contralateral Slipped Capital Femoral Epiphysis in an Asian Population. 61
31788171 2019

Variations for Slipped Capital Femoral Epiphysis

Expression for Slipped Capital Femoral Epiphysis

Search GEO for disease gene expression data for Slipped Capital Femoral Epiphysis.

Pathways for Slipped Capital Femoral Epiphysis

Pathways related to Slipped Capital Femoral Epiphysis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 IGFBP3 IGF1
2
Show member pathways
11.69 IGFBP3 IGF1
3 11.54 IGFBP3 IGF1
4 11.18 IGFBP3 IGF1
5 10.93 IGFBP3 IGF1
6 9.95 IGFBP3 IGF1

GO Terms for Slipped Capital Femoral Epiphysis

Cellular components related to Slipped Capital Femoral Epiphysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor ternary complex GO:0042567 8.96 IGFBP3 IGF1
2 insulin-like growth factor binding protein complex GO:0016942 8.62 IGFBP3 IGF1

Biological processes related to Slipped Capital Femoral Epiphysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.16 IGFBP3 IGF1
2 positive regulation of MAPK cascade GO:0043410 8.96 IGFBP3 IGF1
3 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.62 IGFBP3 IGF1

Sources for Slipped Capital Femoral Epiphysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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