MCID: SLP010
MIFTS: 37

Slipped Capital Femoral Epiphysis

Categories: Rare diseases

Aliases & Classifications for Slipped Capital Femoral Epiphysis

MalaCards integrated aliases for Slipped Capital Femoral Epiphysis:

Name: Slipped Capital Femoral Epiphysis 53
Slipped Capital Femoral Epiphyses 73

Classifications:



External Ids:

UMLS 73 C0149887

Summaries for Slipped Capital Femoral Epiphysis

MalaCards based summary : Slipped Capital Femoral Epiphysis, also known as slipped capital femoral epiphyses, is related to turner syndrome and central precocious puberty. An important gene associated with Slipped Capital Femoral Epiphysis is NPR2 (Natriuretic Peptide Receptor 2), and among its related pathways/superpathways are DNA Damage Response and Transcriptional misregulation in cancer. The drugs Methyclothiazide and diuretics have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and pituitary, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : 76 Slipped capital femoral epiphysis (SCFE or skiffy, slipped upper femoral epiphysis, SUFE or souffy, coxa... more...

Related Diseases for Slipped Capital Femoral Epiphysis

Diseases related to Slipped Capital Femoral Epiphysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 turner syndrome 29.9 IGF1 IGFBP3
2 central precocious puberty 29.9 IGF1 IGFBP3
3 growth hormone deficiency 29.8 IGF1 IGFBP3
4 hypothyroidism 29.7 IGF1 IGFBP3
5 prader-willi syndrome 29.2 IGF1 IGFBP3
6 epiphysiolysis of the hip 11.5
7 epiphyseal chondrodysplasia, miura type 11.4
8 legg-calve-perthes disease 11.4
9 osteonecrosis 10.6
10 aging 10.6
11 body mass index quantitative trait locus 1 10.5
12 hyperparathyroidism 10.5
13 osteoarthritis 10.5
14 primary hyperparathyroidism 10.5
15 avascular necrosis of femoral head, primary, 1 10.4
16 arthritis 10.4
17 osteopetrosis 10.4
18 gigantism 10.4
19 down syndrome 10.4
20 renal osteodystrophy 10.4
21 chromosome 16p13.3 deletion syndrome, proximal 10.3
22 pseudohypoparathyroidism 10.3
23 precocious puberty 10.3
24 blount's disease 10.2
25 seizure disorder 10.2
26 cerebritis 10.2
27 craniopharyngioma 10.2
28 cerebral palsy 10.2
29 pituitary hypoplasia 10.2
30 septic arthritis 10.2
31 intracranial hypertension 10.2
32 coxa vara 10.2
33 congenital hypothyroidism 10.2
34 sickle cell disease 10.2
35 scoliosis 10.2
36 bone disease 10.2
37 neonatal hypothyroidism 10.2
38 hypomagnesemia 3, renal 10.2
39 nephrocalcinosis 10.2
40 headache 10.2
41 parathyroid carcinoma 10.2
42 pituitary tumors 10.2
43 secondary adrenal insufficiency 9.8 IGF1 IGFBP3
44 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 9.8 IGF1 IGFBP3
45 pituitary adenoma 1, multiple types 9.8 IGF1 IGFBP3
46 diffuse idiopathic skeletal hyperostosis 9.8 IGF1 IGFBP3
47 mammographic density 9.8 IGF1 IGFBP3
48 hyperpituitarism 9.8 IGF1 IGFBP3
49 isolated growth hormone deficiency, type ib 9.8 IGF1 IGFBP3
50 acid-labile subunit deficiency 9.8 IGF1 IGFBP3

Graphical network of the top 20 diseases related to Slipped Capital Femoral Epiphysis:



Diseases related to Slipped Capital Femoral Epiphysis

Symptoms & Phenotypes for Slipped Capital Femoral Epiphysis

MGI Mouse Phenotypes related to Slipped Capital Femoral Epiphysis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.33 IGF1 IGFBP3 NPR2
2 muscle MP:0005369 9.13 NPR2 IGF1 IGFBP3
3 respiratory system MP:0005388 8.8 NPR2 IGF1 IGFBP3

Drugs & Therapeutics for Slipped Capital Femoral Epiphysis

Drugs for Slipped Capital Femoral Epiphysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyclothiazide Approved Phase 4 135-07-9 4121
2 diuretics Phase 4
3 Natriuretic Agents Phase 4
4 Sodium Chloride Symporter Inhibitors Phase 4
5 Gentamicins Phase 4
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9 Anti-Bacterial Agents Phase 4
10 Anti-Infective Agents Phase 4
11
Pamidronate Approved Not Applicable 40391-99-9 4674
12 Diphosphonates Not Applicable
13 Bone Density Conservation Agents Not Applicable

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Study to Assess the Long-term Performance of SmartSet® HV and SmartSet® GHV Bone Cements in Primary Total Hip Replacement Completed NCT00872066 Phase 4
2 A Randomised Single Centre Study to Compare the Long-term Wear Characteristics of Marathon™ and Enduron™ Polyethylene Cup Liners in Primary Total Hip Replacement Completed NCT00208442 Phase 4
3 Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome Completed NCT00266656 Phase 4 Humatrope
4 A Randomised Study to Compare Metal Ion Release and Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-Metal or a Metal-on-Metal Bearing Terminated NCT00873444 Phase 4
5 A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery Terminated NCT00872794 Phase 4
6 A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stem™ AMT in a Total Primary Hip Replacement Terminated NCT00872573 Phase 4
7 Multi-Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Resurfacing and Primary Total Hip Replacement Terminated NCT00872547 Phase 4
8 A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement Terminated NCT00872222 Phase 4
9 A Multi-centre Study to Assess the Long-term Performance of the Summit™ Hip in Primary Total Hip Replacement Terminated NCT00208390 Phase 4
10 A Multi-centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery Terminated NCT00208377 Phase 4
11 A Two Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Metal-on-Metal Bearing in Primary Total Hip Replacement Terminated NCT00208364 Phase 4
12 A Multi-centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Polyethylene-on-metal Bearing in Primary Total Hip Replacement Withdrawn NCT00208429 Phase 4
13 A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement Terminated NCT00208468 Phase 3
14 A Randomised Single Centre Study to Compare the Long-term Performance of 4 Designs of the DePuy Ultima LX Stem in Primary Total Hip Replacement Terminated NCT00208351 Phase 3
15 Evaluation of Skeletal Maturity for Slipped Capital Femoral Epiphysis Unknown status NCT01220882 Not Applicable
16 "Gait and Balance in Patients With SCFE" Recruiting NCT03326531
17 Slipped Capital Femoral Epiphysis Treatment Not yet recruiting NCT03229590
18 The Use of Bisphosphonates in the Treatment of Avascular Necrosis of the Femoral Head Terminated NCT02007915 Not Applicable Pamidronate Disodium

Search NIH Clinical Center for Slipped Capital Femoral Epiphysis

Genetic Tests for Slipped Capital Femoral Epiphysis

Anatomical Context for Slipped Capital Femoral Epiphysis

MalaCards organs/tissues related to Slipped Capital Femoral Epiphysis:

41
Bone, Testes, Pituitary, Eye

Publications for Slipped Capital Femoral Epiphysis

Articles related to Slipped Capital Femoral Epiphysis:

(show top 50) (show all 654)
# Title Authors Year
1
Incremental Value of SPECT/CT in the Detection of Femoral Head Viability in Slipped Capital Femoral Epiphysis. ( 29438004 )
2018
2
Diagnosing slipped capital femoral epiphysis amongst various medical specialists. ( 29707055 )
2018
3
Slipped Capital Femoral Epiphysis: The European Perspective. ( 29877936 )
2018
4
Diagnosis and treatment of slipped capital femoral epiphysis: Recent trends to note. ( 29361376 )
2018
5
Comparison between modified Dunn procedure and in situ fixation for severe stable slipped capital femoral epiphysis. ( 29451057 )
2018
6
The reliability of radiostereometric analysis in determining physeal motion in slipped capital femoral epiphysis in standard uniplanar and low-dose EOS biplanar radiography: a phantom model study. ( 29762188 )
2018
7
CORR InsightsAr: Morphologic Features of the Contralateral Femur in Patients With Unilateral Slipped Capital Femoral Epiphysis Resembles Mild Slip Deformity: A Matched Cohort Study. ( 29481357 )
2018
8
The modified Dunn procedure provides superior short-term outcomes in the treatment of the unstable slipped capital femoral epiphysis as compared to the inadvertent closed reduction and percutaneous pinning: a comparative clinical study. ( 29797165 )
2018
9
Increased time between diagnosis and surgery in slipped capital femoral epiphysis results in increased radiographic deformity. ( 29951122 )
2018
10
Persisting CAM deformity is associated with early cartilage degeneration after Slipped Capital Femoral Epiphysis: 11-year follow-up including dGEMRIC. ( 29426010 )
2018
11
The Peritubercle Lucency Sign is a Common and Early Radiographic Finding in Slipped Capital Femoral Epiphysis. ( 29889771 )
2018
12
Valgus Slipped Capital Femoral Epiphysis: Pathophysiology of Motion and Results of Intracapsular Realignment. ( 29373445 )
2018
13
Surgical treatment of femoroacetabular impingement after slipped capital femoral epiphysis. ( 29206650 )
2018
14
Obesity-related metabolic and endocrine disorders diagnosed during postoperative follow-up of slipped capital femoral epiphysis. ( 29521181 )
2018
15
The S Sign: A New Radiographic Tool to Aid in the Diagnosis of Slipped Capital Femoral Epiphysis. ( 29550284 )
2018
16
Morphologic Features of the Contralateral Femur in Patients With Unilateral Slipped Capital Femoral Epiphysis Resembles Mild Slip Deformity: A Matched Cohort Study. ( 29481345 )
2018
17
Femoral pseudoaneurysm as a complication of slipped capital femoral epiphysis treatment. ( 29367918 )
2018
18
Intracapsular cuneiform osteotomy compared with in-situ pinning for the management of slipped capital femoral epiphysis. ( 29878978 )
2018
19
Suprasellar Germinoma Presenting with Slipped Capital Femoral Epiphysis: Case Report. ( 29487768 )
2017
20
Asynchronous slipped capital femoral epiphysis in a patient with a seizure disorder: case report and review of the literature. ( 28657919 )
2017
21
Residual Femoral Deformity and Femoroacetabular Impingement after Intertrochanteric Osteotomy for Slipped Capital Femoral Epiphysis. ( 28824187 )
2017
22
Femoral and acetabular re-alignment in slipped capital femoral epiphysis. ( 28529662 )
2017
23
Outcome of pinning in patients with slipped capital femoral epiphysis: risk factors associated with avascular necrosis, chondrolysis, and femoral impingement. ( 29210310 )
2017
24
3-dimensional metrics of proximal femoral shape deformities in Legg-CalvAc-Perthes disease and slipped capital femoral epiphysis. ( 29087625 )
2017
25
Treatment of stable slipped capital femoral epiphysis: systematic review and exploratory patient level analysis. ( 28831651 )
2017
26
Special symposium issue: slipped capital femoral epiphysis (SCFE). ( 28529653 )
2017
27
Treatment of chronic, stable slipped capital femoral epiphysis via surgical hip dislocation with combined osteochondroplasty and Imhauser osteotomy. ( 28904634 )
2017
28
The modified Dunn procedure for slipped capital femoral epiphysis: the Bernese experience. ( 28529663 )
2017
29
Opinion survey of members of British Society of Children's Orthopaedic Surgery related to specific case scenarios in slipped capital femoral epiphysis. ( 28079739 )
2017
30
Slipped capital femoral epiphysis in children younger than 10 years old: clinical characteristics and efficacy of physeal-sparing procedures. ( 28704299 )
2017
31
Biomechanical Evaluation of the Depth of Resection During Femoral Neck Osteoplasty for Anterior Impingement Following Slipped Capital Femoral Epiphysis. ( 28244926 )
2017
32
A nationwide cohort study of slipped capital femoral epiphysis. ( 28663349 )
2017
33
Slipped capital femoral epiphysis management and the arthroscope. ( 28529661 )
2017
34
Biomechanical considerations in slipped capital femoral epiphysis and insights into prophylactic fixation. ( 28529660 )
2017
35
Acetabular Retroversion, but Not Increased Acetabular Depth or Coverage, in Slipped Capital Femoral Epiphysis: A Matched-Cohort Study. ( 28632591 )
2017
36
Patient-specific 3D models aid planning for triplane proximal femoral osteotomy in slipped capital femoral epiphysis. ( 28529664 )
2017
37
Slipped capital femoral epiphysis: a spectrum of surgical care and changes over time. ( 28529665 )
2017
38
Slipped capital femoral epiphysis: a population-based study. ( 28720145 )
2017
39
Arthroscopic Subcapital Realignment in Chronic and Stable Slipped Capital Femoral Epiphysis. ( 28706815 )
2017
40
A comparison study of radiographic and computerized tomographic angles in slipped capital femoral epiphysis. ( 29062815 )
2017
41
Femoral head fracture similar to slipped capital femoral epiphysis in an elderly woman with antecedent hip osteoarthritis after subchondral insufficiency fracture: A case report. ( 28967534 )
2017
42
Instability of the hip after anatomical re-alignment in patients with a slipped capital femoral epiphysis. ( 28053252 )
2017
43
Seasonal Variation in Slipped Capital Femoral Epiphysis: New Findings Using a National Children's Hospital Database. ( 28961634 )
2017
44
Fixation in slipped capital femoral epiphysis avoiding femoral-acetabular impingement. ( 29084548 )
2017
45
Good inter- and intraobserver reliability for assessment of the slip angle in 77 hip radiographs of children with a slipped capital femoral epiphysis. ( 29212388 )
2017
46
Surgical treatment of femoroacetabular impingement following slipped capital femoral epiphysis: A systematic review. ( 28790036 )
2017
47
Magnetic resonance imaging at primary diagnosis cannot predict subsequent contralateral slip in slipped capital femoral epiphysis. ( 28785827 )
2017
48
Slipped Capital Femoral Epiphysis: Diagnosis and Management. ( 28671425 )
2017
49
Early osteoarthritis after slipped capital femoral epiphysis. ( 29172934 )
2017
50
Prepubertal onset of slipped capital femoral epiphysis associated with hypothyroidism: a case report and literature review. ( 28923047 )
2017

Variations for Slipped Capital Femoral Epiphysis

Expression for Slipped Capital Femoral Epiphysis

Search GEO for disease gene expression data for Slipped Capital Femoral Epiphysis.

Pathways for Slipped Capital Femoral Epiphysis

GO Terms for Slipped Capital Femoral Epiphysis

Cellular components related to Slipped Capital Femoral Epiphysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
2 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Slipped Capital Femoral Epiphysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.16 IGF1 IGFBP3
2 positive regulation of MAPK cascade GO:0043410 8.96 IGF1 IGFBP3
3 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.62 IGF1 IGFBP3

Sources for Slipped Capital Femoral Epiphysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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