SNCV
MCID: SLW005
MIFTS: 32

Slowed Nerve Conduction Velocity, Autosomal Dominant (SNCV)

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Slowed Nerve Conduction Velocity, Autosomal Dominant

MalaCards integrated aliases for Slowed Nerve Conduction Velocity, Autosomal Dominant:

Name: Slowed Nerve Conduction Velocity, Autosomal Dominant 56 29 6 71
Slowed Nerve Conduction Velocity, Ad 56 13
Sncv 56 73
Nerve Conduction Velocity, Slowed, Autosomal Dominant 39
Autosomal Dominant Slowed Nerve Conduction Velocity 58
Slowed Nerve Conduction Velocity 73

Characteristics:

Orphanet epidemiological data:

58
autosomal dominant slowed nerve conduction velocity
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

OMIM:

56
Miscellaneous:
adult onset
usually clinically asymptomatic

Inheritance:
autosomal dominant


HPO:

31
slowed nerve conduction velocity, autosomal dominant:
Inheritance autosomal dominant inheritance
Onset and clinical course adult onset


Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

OMIM 56 608236
ICD10 via Orphanet 33 G60.0
UMLS via Orphanet 72 C1842357
Orphanet 58 ORPHA140481
MedGen 41 C1842357
SNOMED-CT via HPO 68 263681008
UMLS 71 C1842357

Summaries for Slowed Nerve Conduction Velocity, Autosomal Dominant

UniProtKB/Swiss-Prot : 73 Slowed nerve conduction velocity: Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant.

MalaCards based summary : Slowed Nerve Conduction Velocity, Autosomal Dominant, also known as slowed nerve conduction velocity, ad, is related to neuropathy, congenital hypomyelinating, 1, autosomal recessive and hypertrophic neuropathy of dejerine-sottas. An important gene associated with Slowed Nerve Conduction Velocity, Autosomal Dominant is ARHGEF10 (Rho Guanine Nucleotide Exchange Factor 10). The drug Ethanol has been mentioned in the context of this disorder. Affiliated tissues include testes, dorsal root ganglion and bone, and related phenotypes are decreased nerve conduction velocity and peripheral demyelination

More information from OMIM: 608236

Related Diseases for Slowed Nerve Conduction Velocity, Autosomal Dominant

Diseases related to Slowed Nerve Conduction Velocity, Autosomal Dominant via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 9, show less)
# Related Disease Score Top Affiliating Genes
1 neuropathy, congenital hypomyelinating, 1, autosomal recessive 11.6
2 hypertrophic neuropathy of dejerine-sottas 11.5
3 charcot-marie-tooth disease, demyelinating, type 1a 11.4
4 charcot-marie-tooth disease and deafness 11.4
5 neuropathy, congenital hypomyelinating, 2 11.4
6 neuropathy, congenital hypomyelinating, 3 11.4
7 kidney disease 10.3
8 peripheral nervous system disease 10.0
9 neuropathy 10.0

Graphical network of the top 20 diseases related to Slowed Nerve Conduction Velocity, Autosomal Dominant:



Diseases related to Slowed Nerve Conduction Velocity, Autosomal Dominant

Symptoms & Phenotypes for Slowed Nerve Conduction Velocity, Autosomal Dominant

Human phenotypes related to Slowed Nerve Conduction Velocity, Autosomal Dominant:

31 (showing 3, show less)
# Description HPO Frequency HPO Source Accession
1 decreased nerve conduction velocity 31 HP:0000762
2 peripheral demyelination 31 HP:0011096
3 onion bulb formation 31 HP:0003383

Symptoms via clinical synopsis from OMIM:

56
Neurologic Peripheral Nervous System:
slowed nerve conduction velocities (ncv)
nerve biopsy may show demyelination and remyelination
'onion bulb' formations (rare)

Clinical features from OMIM:

608236

Drugs & Therapeutics for Slowed Nerve Conduction Velocity, Autosomal Dominant

Drugs for Slowed Nerve Conduction Velocity, Autosomal Dominant (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 1, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved 64-17-5 702

Interventional clinical trials:

(showing 2, show less)
# Name Status NCT ID Phase Drugs
1 Cutaneous Denervation in Alcoholic Neuropathy Unknown status NCT00190073
2 Efficacy of Pulsed Radiofrequency of the Median Nerve Under Ultrasound Guidance in Patients With Carpal Tunnel Syndrome Completed NCT02217293

Search NIH Clinical Center for Slowed Nerve Conduction Velocity, Autosomal Dominant

Genetic Tests for Slowed Nerve Conduction Velocity, Autosomal Dominant

Genetic tests related to Slowed Nerve Conduction Velocity, Autosomal Dominant:

# Genetic test Affiliating Genes
1 Slowed Nerve Conduction Velocity, Autosomal Dominant 29 ARHGEF10

Anatomical Context for Slowed Nerve Conduction Velocity, Autosomal Dominant

MalaCards organs/tissues related to Slowed Nerve Conduction Velocity, Autosomal Dominant:

40
Testes, Dorsal Root Ganglion, Bone, Spinal Cord

Publications for Slowed Nerve Conduction Velocity, Autosomal Dominant

Articles related to Slowed Nerve Conduction Velocity, Autosomal Dominant:

(showing 219, show less)
# Title Authors PMID Year
1
Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10. 56 6
14508709 2003
2
Mutation analysis of the nerve specific promoter of the peripheral myelin protein 22 gene in CMT1 disease and HNPP. 6 56
9678704 1998
3
Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10). 6
21719701 2011
4
A novel type of hereditary motor and sensory neuropathy characterized by a mild phenotype. 56
10520946 1999
5
Traditional Chinese medicine foot bath combined with acupoint massage for the treatment of diabetic peripheral neuropathy: A systematic review and meta-analysis of 31 RCTs. 61
31659861 2020
6
Curcumin Alleviates Oxaliplatin-Induced Peripheral Neuropathic Pain through Inhibiting Oxidative Stress-Mediated Activation of NF-κB and Mitigating Inflammation. 61
31776306 2020
7
Diagnosis and Management of Carpal Tunnel Syndrome in Children with Mucopolysaccharidosis: A 10 Year Experience. 61
31861915 2019
8
Ultrasound-guided insulin injection for carpal tunnel syndrome in type 2 diabetes mellitus patients. 61
31209710 2019
9
miRNA-155 silencing reduces sciatic nerve injury in diabetic peripheral neuropathy. 61
31404910 2019
10
Protective effect of ibuprofen in a rat model of chronic oxaliplatin-induced peripheral neuropathy. 61
31388734 2019
11
Saponins of Tribulus terrestris attenuated neuropathic pain induced with vincristine through central and peripheral mechanism. 61
29938333 2019
12
Dexamethasone versus Hyaluronidase as an Adjuvant to Local Anesthetics in the Ultrasound-guided Hydrodissection of the Median Nerve for the Treatment of Carpal Tunnel Syndrome Patients. 61
31602055 2019
13
The Effectiveness of Ultrasound-Guided Steroid Injection Combined with Miniscalpel-Needle Release in the Treatment of Carpal Tunnel Syndrome vs. Steroid Injection Alone: A Randomized Controlled Study. 61
30915366 2019
14
[Relationship of BMI and wrist joint index with carpal tunnel syndrome in manual laborers]. 61
30884585 2019
15
The Method of Activating Blood and Dredging Collaterals for Reducing Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis. 61
31281395 2019
16
Prevalence of Diabetic Neuropathy in Young Adults with Type 1 Diabetes and the Association with Insulin Pump Therapy. 61
30461290 2018
17
Prostaglandin E1 plus methylcobalamin combination therapy versus prostaglandin E1 monotherapy for patients with diabetic peripheral neuropathy: A meta-analysis of randomized controlled trials. 61
30383660 2018
18
PVT1 protects diabetic peripheral neuropathy via PI3K/AKT pathway. 61
30402856 2018
19
The LDIFLARE and CCM Methods Demonstrate Early Nerve Fiber Abnormalities in Untreated Hypothyroidism: A Prospective Study. 61
29860452 2018
20
Fasudil combined with methylcobalamin or lipoic acid can improve the nerve conduction velocity in patients with diabetic peripheral neuropathy: A meta-analysis. 61
29979431 2018
21
Efficacy of epalrestat plus α-lipoic acid combination therapy versus monotherapy in patients with diabetic peripheral neuropathy: a meta-analysis of 20 randomized controlled trials. 61
29926837 2018
22
Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR/p70S6K inhibition in Streptozotocin-induced diabetic rats. 61
29294366 2018
23
Extracorporeal shockwave therapy versus exercise program in patients with low back pain: short-term results of a randomised controlled trial. 61
29685023 2018
24
Morin exerts neuroprotection via attenuation of ROS induced oxidative damage and neuroinflammation in experimental diabetic neuropathy. 61
29193444 2018
25
The clinical efficacy of epalrestat combined with α-lipoic acid in diabetic peripheral neuropathy: Protocol for a systematic review and meta-analysis. 61
29419686 2018
26
Efficacy and Safety of the Injection of the Traditional Chinese Medicine Puerarin for the Treatment of Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis of 53 Randomized Controlled Trials. 61
29619066 2018
27
The role of host cell organelles in the development of Simkania negevensis. 61
29089243 2018
28
Gentiopicroside Ameliorates Diabetic Peripheral Neuropathy by Modulating PPAR- Γ/AMPK/ACC Signaling Pathway. 61
30308492 2018
29
Alpha lipoic acid combined with epalrestat: a therapeutic option for patients with diabetic peripheral neuropathy. 61
30233145 2018
30
The Electrophysiological Features in X-Linked Charcot-Marie-Tooth Disease With Transient Central Nervous System Deficits. 61
30013503 2018
31
Transthyretin familial amyloid polyneuropathy (TTR-FAP): Parameters for early diagnosis. 61
29568686 2018
32
Pathophysiological profiles of SDT fatty rats, a potential new diabetic peripheral neuropathy model. 61
28970182 2017
33
Lipoic Acid Combined with Epalrestat versus Lipoic Acid in Treating Diabetic Peripheral Neuropathy:A Meta-analysis. 61
29125108 2017
34
Association Between Manual Loading and Newly Developed Carpal Tunnel Syndrome in Subjects With Physical Disabilities: A Follow-Up Study. 61
28286203 2017
35
Effects of taping therapy for carpal space expansion on electrophysiological change in patients with carpal tunnel syndrome. 61
28702450 2017
36
Efficacy of Combined Ultrasound-Guided Steroid Injection and Splinting in Patients With Carpal Tunnel Syndrome: A Randomized Controlled Trial. 61
28209506 2017
37
Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation. 61
26957299 2017
38
Risk factors for autonomic and somatic nerve dysfunction in different stages of glucose tolerance. 61
27894750 2017
39
Reversible median nerve impairment after three weeks of repetitive work. 61
28060387 2017
40
Diabetic Neuropathy Evaluated by a Novel Device: Sural Nerve Conduction Is Associated with Glycemic Control and Ankle-Brachial Pressure Index in Japanese Patients with Diabetes. 61
28861044 2017
41
A Comparison of Screening Tools for the Early Detection of Peripheral Neuropathy in Adults with and without Type 2 Diabetes. 61
29250555 2017
42
MiR-106a Associated with Diabetic Peripheral Neuropathy Through the Regulation of 12/15-LOX-meidiated Oxidative/Nitrative Stress. 61
28393703 2017
43
Neuropathy in the spontaneously hypertensive rat: An electrophysiological and histological study. 61
26970072 2016
44
Quantitative assessment of chemotherapy-induced peripheral neurotoxicity using a point-of-care nerve conduction device. 61
27412083 2016
45
Nerve conduction velocity in CMT1A: what else can we tell? 61
27412484 2016
46
Efficacy and safety of prostaglandin E1 plus lipoic acid combination therapy versus monotherapy for patients with diabetic peripheral neuropathy. 61
26775115 2016
47
[Effect of Tanshinone IIA in Preventing and Treating Oxaliplatin Induced Peripheral Neuropathy]. 61
27386647 2016
48
[Acupuncture for distal symmetric multiple peripheral neuropathy of diabetes mellitus: a randomized controlled trial]. 61
27509606 2016
49
LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia. 61
27107575 2016
50
Long-Acting C-Peptide and Neuropathy in Type 1 Diabetes: A 12-Month Clinical Trial. 61
26884473 2016
51
Normal Motor and Sensory Nerve Conduction Velocity of Radial Nerve in Young Adult Medical Students. 61
26894058 2016
52
Study of Electrophysiological Changes in Sensory Nerves Among Diabetic Smokers. 61
26894060 2016
53
Proteomic analysis of the Simkania-containing vacuole: the central role of retrograde transport. 61
26374382 2016
54
Gallic acid and exercise training improve motor function, nerve conduction velocity but not pain sense reflex after experimental sciatic nerve crush in male rats. 61
26445710 2015
55
Assessment of chemotherapy-induced peripheral neuropathy using the LDIFLARE technique: a novel technique to detect neural small fiber dysfunction. 61
26221574 2015
56
Near-normoglycaemia and development of neuropathy: a 24-year prospective study from diagnosis of type 1 diabetes. 61
26109108 2015
57
Effects of prostaglandin E1 plus methylcobalamin alone and in combination with lipoic acid on nerve conduction velocity in patients with diabetic peripheral neuropathy: A meta-analysis. 61
25800109 2015
58
[Effects of Tongxinluo capsule on sciatic nerve apoptosis in spontaneous type II diabetic KK/Upj-Ay mice and mechanism research]. 61
26281568 2015
59
Antioxidation and anti-inflammatory activity of Tang Bi Kang in rats with diabetic peripheral neuropathy. 61
25887432 2015
60
Oxidative stress predicts progression of peripheral and cardiac autonomic nerve dysfunction over 6 years in diabetic patients. 61
24898524 2015
61
Peripheral Nerve Diffusion Tensor Imaging: Assessment of Axon and Myelin Sheath Integrity. 61
26114630 2015
62
Ultrasound-Guided Pulsed Radiofrequency for Carpal Tunnel Syndrome: A Single-Blinded Randomized Controlled Study. 61
26067628 2015
63
Assessment of diabetic neuropathy using a point-of-care nerve conduction device shows significant associations with the LDIFLARE method and clinical neuropathy scoring. 61
25231114 2015
64
Effects of colistin on the sensory nerve conduction velocity and F-wave in mice. 61
24861773 2014
65
[Dynamic changes of sciatic nerve conduction velocity in rats infected with Toxoplasma gondii]. 61
25902674 2014
66
Influence of the long term use of a computer on median, ulnar and radial sensory nerves in the wrist region. 61
25503896 2014
67
Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat. 61
25128849 2014
68
Meta-analysis of methylcobalamin alone and in combination with prostaglandin E1 in the treatment of diabetic peripheral neuropathy. 61
24522613 2014
69
Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions. 61
24559476 2014
70
Deterioration after corticosteroids in CIDP may be associated with pure focal demyelination pattern. 61
24708554 2014
71
The usefulness of terminal latency index of median nerve and f-wave difference between median and ulnar nerves in assessing the severity of carpal tunnel syndrome. 61
24691235 2014
72
Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice. 61
24843734 2014
73
A clinical and neuropathological study of Chinese patients with diabetic peripheral neuropathy. 61
24618902 2014
74
Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy. 61
24790009 2014
75
Clinical, electrophysiological and magnetic resonance findings in a family with hereditary neuropathy with liability to pressure palsies caused by a novel PMP22 mutation. 61
24239057 2014
76
Reliability and validity of a point-of-care sural nerve conduction device for identification of diabetic neuropathy. 61
24466129 2014
77
Glutamate carboxypeptidase II inhibition behaviorally and physiologically improves pyridoxine-induced neuropathy in rats. 61
25254647 2014
78
Calbindin content and differential vulnerability of midbrain efferent dopaminergic neurons in macaques. 61
25520629 2014
79
Diagnostic utility of F waves in clinically diagnosed patients of carpal tunnel syndrome. 61
24968575 2013
80
Cuprizone-induced demyelination in Wistar rats; electrophysiological and histological assessment. 61
24174351 2013
81
Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. 61
23664235 2013
82
A manual therapy intervention improves symptoms in patients with carpal tunnel syndrome: a pilot study. 61
23064542 2013
83
Nerve conduction studies in the upper limb in the malwa region-normative data. 61
23542663 2013
84
A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy. 61
22837391 2012
85
[Establishment of H reflex model in mice with minimal insult and measurement of nerve conduction velocity]. 61
22907309 2012
86
Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. 61
22687395 2012
87
Treatment with Actovegin® improves sensory nerve function and pathology in streptozotocin-diabetic rats via mechanisms involving inhibition of PARP activation. 61
22020669 2012
88
Effects of acute organophosphorus poisoning on function of peripheral nerves: a cohort study. 61
23185328 2012
89
Inactivation of TNF-α ameliorates diabetic neuropathy in mice. 61
21810933 2011
90
Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice. 61
21617845 2011
91
Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice. 61
21810596 2011
92
Effective compounds group of Mongolian prescriptions BAIMAI-SAN protect against peripheral neuropathy in lower limbs of rats through neuro protective effect. 61
21527327 2011
93
Evaluating the effectiveness of local dexamethasone injection in pregnant women with carpal tunnel syndrome. 61
22091293 2011
94
Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy. 61
21118710 2011
95
Sensory neuropathy in patients with cryoglobulin negative hepatitis-C infection. 61
20683606 2011
96
Treatment with statins and peripheral neuropathy: results of 36-months a prospective clinical and neurophysiological follow-up. 61
22167150 2011
97
Studies on oxidative stress induced nerve conduction deficits in cigarette smokers. 61
21888230 2011
98
Transplantation of bone marrow-derived mononuclear cells improves mechanical hyperalgesia, cold allodynia and nerve function in diabetic neuropathy. 61
22125614 2011
99
Minocycline with aspirin: a therapeutic approach in the treatment of diabetic neuropathy. 61
20213226 2010
100
Sensory nerve conduction and nociception in the equine lower forelimb during perineural bupivacaine infusion along the palmar nerves. 61
21197231 2010
101
Upgraded nerve growth factor expression induced by low-intensity continuous-wave ultrasound accelerates regeneration of neurotometicly injured sciatic nerve in rats. 61
20620698 2010
102
Electrophysiological sensory demyelination in typical chronic inflammatory demyelinating polyneuropathy. 61
20158514 2010
103
Autologous blood injection in carpal tunnel syndrome (CTS). 61
20058545 2009
104
Rosuvastatin positively changes nerve electrophysiology in diabetic rats. 61
19172598 2009
105
Interleukin-6 protects against paclitaxel, cisplatin and vincristine-induced neuropathies without impairing chemotherapeutic activity. 61
18270703 2008
106
Somatosensory evoked potentials and sensory nerve conduction velocities in the thoracic limb of mallard ducks (Anas platyrhynchos). 61
18980430 2008
107
Impact of anthropmetric measures on sural nerve conduction in healthy subjects. 61
19999220 2008
108
[Effects of lisinopril on diabetic peripheral neuropathy: experiment with rats]. 61
19080636 2008
109
Identification of differentially expressed genes in dorsal root ganglion in early diabetic rats. 61
18668150 2008
110
The effect of different warming methods on sensory nerve conduction velocity in shipyard workers occupationally exposed to hand-arm vibration. 61
18196262 2008
111
The effects of low level laser in clinical outcome and neurophysiological results of carpal tunnel syndrome. 61
18754533 2008
112
Muscle fiber conduction abnormalities in early diabetic polyneuropathy. 61
18387339 2008
113
Syndromes from segmental vibration and nerve entrapment: observations on case definitions for carpal tunnel syndrome. 61
17909837 2008
114
Thermal effect of sonophoresis for accelerating the analgesic effect of local anesthetics on rat tail nerve. 61
19163212 2008
115
MRI measurement of the canine auditory pathways and relationship with brainstem auditory evoked responses. 61
18536850 2008
116
Vascular and neural dysfunction in Zucker diabetic fatty rats: a difficult condition to reverse. 61
17970755 2008
117
Evaluation of the peroxynitrite decomposition catalyst Fe(III) tetra-mesitylporphyrin octasulfonate on peripheral neuropathy in a mouse model of type 1 diabetes. 61
17982684 2007
118
Treatment with statins and involvement of the peripheral nervous system: results of a prospective clinical and neurophysiological follow-up. 61
18345269 2007
119
[Effects of pricking bleeding at "Weizhong" (BL40) on sciatic nerve conduction velocity and interleukin-1alpha content in the lumbar vertebral nucleus pulposus in experimental lumbar intervertebral disc protrusion rabbits]. 61
18050623 2007
120
Towards development of a nonhuman primate model of carpal tunnel syndrome: performance of a voluntary, repetitive pinching task induces median mononeuropathy in Macaca fascicularis. 61
17318891 2007
121
Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice. 61
17475250 2007
122
Effect of cerivastatin on peripheral capillary permeability to albumin and peripheral nerve function in diabetic rats. 61
17379559 2007
123
Bortezomib-induced peripheral neurotoxicity: a neurophysiological and pathological study in the rat. 61
17214983 2007
124
Medial calcaneal neuropathy is associated with plantar fasciitis. 61
17095287 2007
125
Comparison of CMT1A and CMT2: similarities and differences. 61
16941080 2006
126
The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity. 61
17130477 2006
127
Rituximab therapy in monoclonal IgM-related neuropathies. 61
16753870 2006
128
Nerve conduction and sensorineural function in dental hygienists using high frequency ultrasound handpieces. 61
16570257 2006
129
Interleukin-6 attenuates the development of experimental diabetes-related neuropathy. 61
16521477 2006
130
Motor and sensory nerve conduction velocities in Yucatan minipigs. 61
16460588 2006
131
Intraepidermal nerve fiber density in rat foot pad: neuropathologic-neurophysiologic correlation. 61
15958131 2005
132
Low-dose poly(ADP-ribose) polymerase inhibitor-containing combination therapies reverse early peripheral diabetic neuropathy. 61
15855340 2005
133
Striatal expression of GDNF and differential vulnerability of midbrain dopaminergic cells. 61
15869477 2005
134
[Effects of Shenmai Huoxue Decoction on early diabetic peripheral neuropathy in rats]. 61
15644157 2005
135
Determination of functional and morphologic changes in palmar digital nerves after nonfocused extracorporeal shock wave treatment in horses. 61
15631039 2004
136
Expression of dopamine and vesicular monoamine transporters and differential vulnerability of mesostriatal dopaminergic neurons. 61
15452855 2004
137
Segmental nerve conduction velocity in vibration-exposed shipyard workers. 61
14985999 2004
138
Electrophysiological abnormalities in upper extremities after brachiocephalic A-V fistulas construction in predialysis patients. 61
15287193 2004
139
Paclitaxel and Cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine. 61
14654561 2003
140
BGP-15, a hydroximic acid derivative, protects against cisplatin- or taxol-induced peripheral neuropathy in rats. 61
12831778 2003
141
Effect of erythropoietin therapy on polyneuropathy in predialytic patients. 61
12649543 2003
142
[The clinical and pathologic features of Charcot-Marie-Tooth disease]. 61
12485517 2002
143
Effect of BRX-220 against peripheral neuropathy and insulin resistance in diabetic rat models. 61
12079878 2002
144
Risk factors of nerve injury during mandibular sagittal split osteotomy. 61
11936397 2002
145
Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of the rat. 61
11720843 2001
146
Muscle sympathetic nerve activity in patients with lumbar spinal canal stenosis. 61
11598620 2001
147
Sensory nerve somatosensory evoked potentials as add-on diagnostic procedure to imaging procedures in patients with sciatica. 61
11680856 2001
148
Neurophysiological changes in COPD patients with chronic respiratory insufficiency. 61
11817264 2001
149
Early diagnosis of carpal tunnel syndrome: comparison of digit 1 with wrist and distoproximal ratio. 61
12396863 2001
150
Methods for assessing diabetic polyneuropathy: validity and reproducibility of the measurement of sensory symptom severity and nerve function tests. 61
10670907 2000
151
Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs. 61
10732773 2000
152
Electrodiagnostic features of hereditary neuropathy with liability to pressure palsies. 61
10636123 2000
153
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy. 61
10499773 1999
154
Neurophysiological evaluation of areflexia in Holmes-Adie syndrome. 61
10431290 1999
155
Continuous inhibition of excessive polyol pathway flux in peripheral nerves by aldose reductase inhibitor fidarestat leads to improvement of diabetic neuropathy. 61
10509874 1999
156
A new technique for recording sensory conduction velocity of the inferior alveolar nerve. 61
10204779 1999
157
Assessment of dorsal nerve root and spinal cord dorsal horn function in clinically normal dogs by determination of cord dorsum potentials. 61
10048556 1999
158
Carpal tunnel syndrome involving unaffected limbs of stroke patients. 61
9933281 1999
159
Neuroprotective interactions in rats between paclitaxel and cisplatin. 61
10691031 1999
160
Glycemic control is related to the electrophysiologic severity of diabetic peripheral sensorimotor polyneuropathy. 61
9773742 1998
161
Carpal tunnel syndrome: reappraisal of five clinical tests. 61
9809232 1998
162
NT-3 attenuates functional and structural disorders in sensory nerves of galactose-fed rats. 61
9737543 1998
163
A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. 61
9686927 1998
164
Effects of the peptide HP228 on nerve disorders in diabetic rats. 61
9627361 1998
165
Serial changes of sensory nerve conduction velocity and minimal F-wave latency in streptozotocin-induced diabetic rats. 61
9593516 1998
166
BDNF attenuates functional and structural disorders in nerves of galactose-fed rats. 61
9413278 1997
167
Neurophysiological classification and sensitivity in 500 carpal tunnel syndrome hands. 61
9325471 1997
168
Surgical prognosis in carpal tunnel syndrome: usefulness of a preoperative neurophysiological assessment. 61
8947287 1996
169
Nerve conduction velocity in human limbs with late sequelae after local cold injury. 61
8817155 1996
170
Neuromyotonia, peripheral neuropathy and myasthenia gravis. 61
8622730 1996
171
Sympathetic vasomotor dysfunction in leprosy patients: comparison with electrophysiological measurement and qualitative sensation testing. 61
8848282 1996
172
A useful electrophysiologic parameter for diagnosis of carpal tunnel syndrome. 61
8538669 1996
173
Evaluating function of the inferior alveolar nerve with repeated nerve conduction tests during mandibular sagittal split osteotomy. 61
7861277 1995
174
Health status of the workers using mechanized hand tools in an electric parts' maker. 61
9150982 1995
175
BAEP and E.M.G. changes from whiplash injuries. 61
7709797 1994
176
Study of nerve conduction velocity, somatosensory-evoked potential and late responses (H-reflex and F-wave) of posterior tibial nerve in leprosy. 61
7868958 1994
177
Protection against cisplatin induced neurotoxicity by ORG 2766: histological and electrophysiological evidence. 61
7853014 1994
178
Sensory neural conduction of median nerve from digits and palm stimulation in carpal tunnel syndrome. 61
7525240 1994
179
Somatosensory evoked potentials (SSEPs); sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) in chronic renal failure. 61
7956880 1994
180
Reduced glutathione protects against cisplatin-induced neurotoxicity in rats. 61
8425186 1993
181
ACTH4-9 analogue ORG 2766 can improve existing neuropathy in streptozocin-induced diabetic rats. 61
8392402 1993
182
Cisplatin-induced neuropathy in mature rats: effects of the melanocortin-derived peptide ORG 2766. 61
8387400 1993
183
Electrophysiological study of four patients with Fisher syndrome: a mechanism of areflexia. 61
1443402 1992
184
[Pattern shift visual evoked potentials in diabetes mellitus]. 61
1433442 1992
185
Somatosensory evoked potentials, sensory nerve potentials and sensory nerve conduction in hereditary motor and sensory neuropathy type I. 61
1607892 1992
186
[Brainstem auditory evoked potentials in diabetes mellitus]. 61
1318148 1992
187
Neurophysiological markers of central and peripheral involvement of the nervous system in HIV-infection. 61
1657459 1991
188
Nerve function in workers with long term exposure to trichloroethene. 61
1998613 1991
189
Diagnostic and prognostic value of electrophysiologic tests in meralgia paresthetica. 61
1846938 1991
190
Asymptomatic ulnar neuropathy in carpal tunnel syndrome. 61
2241548 1990
191
Sensory nerve conduction study in forearm segment of superficial radial nerve: standardization of technique. 61
2123440 1990
192
[Palm stimulation in carpal tunnel syndrome]. 61
2100038 1990
193
Afferent information processing in patients with chronic alcoholism. An evoked potential study. 61
2390207 1990
194
Morphological and electrophysiological study of the effects of cisplatin and ORG.2766 on rat spinal ganglion neurons. 61
2156619 1990
195
Posterior antebrachial cutaneous neuropathy. Case report. 61
2154368 1990
196
Sensory nerve conduction velocities amongst healthy soldiers. 61
2636580 1989
197
[Clinical, electrophysiological and histological analysis of adult onset chronic sensory neuropathy]. 61
2805508 1989
198
[Evaluation of digital vibration threshold for asymptomatic ulnar neuropathy in patients with carpal tunnel syndrome]. 61
2553312 1989
199
[Clinical electrophysiological studies of peroneal muscular atrophy--report of 32 cases]. 61
2529984 1989
200
Cellular distribution of cis-diamminedichloroplatinum(II)-DNA binding in rat dorsal root spinal ganglia: effect of the neuroprotecting peptide ORG.2766. 61
2544043 1989
201
Diagnostic specificity of sensory and motor nerve conduction variables in early detection of carpal tunnel syndrome. 61
2760633 1989
202
Comparison of sensory nerve conduction velocities in horses versus ponies. 61
3266450 1988
203
The natural course of peripheral and autonomic neural function during the first two years after diagnosis of type 1 diabetes. 61
2853250 1988
204
Effects of one year of near-normoglycemia on peripheral nerve function in type 1 (insulin-dependent) diabetic patients. 61
2839729 1988
205
Electrophysiological aspects of nervous conduction in uremia. 61
3396225 1988
206
Somatic and autonomic nerve function during the first year after diagnosis of type 1 (insulin-dependent) diabetes. 61
3046819 1988
207
Effects of continuous subcutaneous insulin infusion and intensified conventional therapy on peripheral and autonomic nerve dysfunction. 61
3033010 1987
208
Peripheral and autonomic nerve function in long-term insulin-dependent diabetes. 61
3032493 1987
209
The influence of simultaneous exposure to carbon disulfide and hydrogen sulfide on the peripheral nerve toxicity and metabolism of carbon disulfide in rats. 61
3798477 1986
210
Assessment of tail nerve function in rats chronically exposed to vinyltoluene. 61
3952770 1986
211
A clinical and electrophysiological study of patients with polychlorinated biphenyl poisoning. 61
2995592 1985
212
Early electrodiagnosis of the ulnar entrapment neuropathy at the elbow. 61
6326345 1984
213
[Sural neurography: comparative study in stimulation with surface and needle electrodes]. 61
6407817 1983
214
New electrophysiological assessments for the early diagnosis of encephalopathy and peripheral neuropathy in chronic uraemia. 61
6302026 1982
215
[Measurements of nerve conduction velocity during decreasing toxic diphenylhydantoin levels and the beginning of carbamazepine medication. A clinical neurophysiological documentation (author's transl)]. 61
7212991 1981
216
Tibial nerve H-reflex and F-wave studies in patients with uremic neuropathy. 61
6252459 1980
217
The carpal tunnel syndrome: localization of conduction abnormalities within the distal segment of the median nerve. 61
497808 1979
218
A method for determining median nerve conduction velocity across the carpal tunnel. 61
702179 1978
219
Sensory (1a) and F-wave conduction velocity in the proximal segment of the tibial nerve. 61
750920 1978

Variations for Slowed Nerve Conduction Velocity, Autosomal Dominant

ClinVar genetic disease variations for Slowed Nerve Conduction Velocity, Autosomal Dominant:

6 (showing 23, show less) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 ARHGEF10 NM_014629.4(ARHGEF10):c.995C>T (p.Thr332Ile)SNV Pathogenic 2526 rs28940281 8:1830835-1830835 8:1882669-1882669
2 ARHGEF10 NM_014629.4(ARHGEF10):c.2063G>A (p.Ser688Asn)SNV Uncertain significance 374306 rs143290224 8:1857556-1857556 8:1909390-1909390
3 ARHGEF10 NM_014629.4(ARHGEF10):c.1812C>A (p.Tyr604Ter)SNV Uncertain significance 812165 8:1851608-1851608 8:1903442-1903442
4 ARHGEF10 NM_014629.4(ARHGEF10):c.133C>T (p.Gln45Ter)SNV Uncertain significance 453261 rs1467438651 8:1806221-1806221 8:1858055-1858055
5 ARHGEF10 NM_014629.4(ARHGEF10):c.3964_3965dup (p.Arg1323fs)duplication Uncertain significance 634605 rs1563343679 8:1905357-1905358 8:1957191-1957192
6 ARHGEF10 NM_014629.4(ARHGEF10):c.1720G>A (p.Glu574Lys)SNV Uncertain significance 590923 rs1437730951 8:1851516-1851516 8:1903350-1903350
7 ARHGEF10 NM_014629.4(ARHGEF10):c.401C>T (p.Ala134Val)SNV Uncertain significance 810896 8:1808270-1808270 8:1860104-1860104
8 ARHGEF10 NM_014629.4(ARHGEF10):c.2909C>T (p.Thr970Met)SNV Likely benign 810874 8:1876804-1876804 8:1928638-1928638
9 ARHGEF10 NM_014629.4(ARHGEF10):c.2259+8T>CSNV Likely benign 522267 rs1015159398 8:1871253-1871253 8:1923087-1923087
10 ARHGEF10 NM_014629.4(ARHGEF10):c.2812G>A (p.Val938Ile)SNV Likely benign 522268 rs61752020 8:1876707-1876707 8:1928541-1928541
11 ARHGEF10 NM_014629.4(ARHGEF10):c.38-10T>CSNV Benign/Likely benign 439416 rs138713415 8:1806116-1806116 8:1857950-1857950
12 ARHGEF10 NM_014629.4(ARHGEF10):c.2098G>A (p.Val700Ile)SNV Benign 439414 rs2294039 8:1857591-1857591 8:1909425-1909425
13 ARHGEF10 NM_014629.4(ARHGEF10):c.387A>G (p.Val129=)SNV Benign 518388 rs749822 8:1808256-1808256 8:1860090-1860090
14 ARHGEF10 NM_014629.4(ARHGEF10):c.630G>A (p.Glu210=)SNV Benign 518389 rs7003969 8:1817367-1817367 8:1869201-1869201
15 ARHGEF10 NM_014629.4(ARHGEF10):c.1075+13A>GSNV Benign 518390 rs4543586 8:1830928-1830928 8:1882762-1882762
16 ARHGEF10 NM_014629.4(ARHGEF10):c.2143+13T>GSNV Benign 518391 rs2294041 8:1857649-1857649 8:1909483-1909483
17 ARHGEF10 NM_014629.4(ARHGEF10):c.3398-16A>GSNV Benign 518392 rs7832438 8:1900855-1900855 8:1952689-1952689
18 ARHGEF10 NM_014629.4(ARHGEF10):c.141A>C (p.Pro47=)SNV Benign 522266 rs4875950 8:1806229-1806229 8:1858063-1858063
19 ARHGEF10 NM_014629.4(ARHGEF10):c.1110G>C (p.Leu370Phe)SNV Benign 618536 rs9657362 8:1833801-1833801 8:1885635-1885635
20 ARHGEF10 NM_014629.4(ARHGEF10):c.1113C>T (p.Phe371=)SNV Benign 618537 rs34655804 8:1833804-1833804 8:1885638-1885638
21 ARHGEF10 NM_014629.4(ARHGEF10):c.1991T>C (p.Met664Thr)SNV Benign 792097 8:1857484-1857484 8:1909318-1909318
22 ARHGEF10 NM_014629.4(ARHGEF10):c.474C>T (p.Asp158=)SNV Benign 726311 8:1808343-1808343 8:1860177-1860177
23 ARHGEF10 NM_014629.4(ARHGEF10):c.1260+4C>TSNV Benign 792096 8:1841816-1841816 8:1893650-1893650

UniProtKB/Swiss-Prot genetic disease variations for Slowed Nerve Conduction Velocity, Autosomal Dominant:

73 (showing 1, show less)
# Symbol AA change Variation ID SNP ID
1 ARHGEF10 p.Thr357Ile VAR_019118 rs28940281

Expression for Slowed Nerve Conduction Velocity, Autosomal Dominant

Search GEO for disease gene expression data for Slowed Nerve Conduction Velocity, Autosomal Dominant.

Pathways for Slowed Nerve Conduction Velocity, Autosomal Dominant

GO Terms for Slowed Nerve Conduction Velocity, Autosomal Dominant

Sources for Slowed Nerve Conduction Velocity, Autosomal Dominant

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