Small Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SML001 MIFTS: 46	Small Cell Carcinoma Categories: Cancer diseases, Genetic diseases, Mental diseases, Rare diseases, Respiratory diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Drugs Expand all tables

Sources

Aliases & Classifications for Small Cell Carcinoma

MalaCards integrated aliases for Small Cell Carcinoma:

Name: Small Cell Carcinoma ¹¹ ¹⁴ ¹⁶

Small Cell Carcinoma, Intermediate Cell ¹¹ ⁷¹

Small Cell Carcinoma - Intermediate Cell ¹¹

Intermediate Cell Small Cell Carcinoma ¹¹

Small Cell Carcinoma of Lung ⁷¹

Carcinoma, Small Cell ⁷¹

Small-Cell Carcinoma ⁷⁵

Classifications:

MalaCards categories:
Global: Cancer diseases Genetic diseases Rare diseases
Anatomical: Respiratory diseases Skin diseases Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0050685

NCIt ⁴⁹ C4099

SNOMED-CT ⁶⁸ 5958006

EFO ¹⁶ EFO_0008524

UMLS ⁷¹ C0149925 C0262584 C0334239

Sources

Summaries for Small Cell Carcinoma

Disease Ontology: ¹¹ A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells.

MalaCards based summary: Small Cell Carcinoma, also known as small cell carcinoma, intermediate cell, is related to ovarian small cell carcinoma and bladder small cell carcinoma. An important gene associated with Small Cell Carcinoma is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways are Neuroscience and Clear cell renal cell carcinoma pathways. The drugs BCG vaccine and Atezolizumab have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and prostate, and related phenotypes are Decreased viability in pancreas lineage and nervous system

Wikipedia: ⁷⁵ Small-cell carcinoma is a type of highly malignant cancer that most commonly arises within the lung,... more...

Sources

Related Diseases for Small Cell Carcinoma

Diseases in the Small Cell Carcinoma family:

Basal Cell Carcinoma 1	Basal Cell Carcinoma 2
Basal Cell Carcinoma 3	Basal Cell Carcinoma 4
Basal Cell Carcinoma 5	Basal Cell Carcinoma 6
Basal Cell Carcinoma 7	Basal Cell Carcinoma
Large Cell Carcinoma	Basal Cell Carcinoma, Multiple

Diseases related to Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 878)

#	Related Disease	Score	Top Affiliating Genes
1	ovarian small cell carcinoma	33.1	SYP ENO2 CHGA
2	bladder small cell carcinoma	33.1	SYP NCAM1 ENO2
3	prostate small cell carcinoma	32.8	SYP ENO2
4	endometrial small cell carcinoma	32.7	SYP NCAM1 ENO2 CHGA
5	thymus small cell carcinoma	32.6	SYP ENO2 CHGA
6	cervix small cell carcinoma	32.6	SYP NCAM1 ENO2 CHGA
7	gastric small cell carcinoma	32.5	SYP NCAM1 ENO2 CHGA
8	laryngeal small cell carcinoma	32.5	SYP NKX2-1 NCAM1 CHGA
9	gallbladder small cell carcinoma	32.2	SYP NCAM1 ENO2 CHGA
10	small cell cancer of the lung	32.2	SYP PTEN NKX2-1 NCAM1 MYCN KRT7
11	ureter small cell carcinoma	32.1	SYP NKX2-1 NCAM1 KRT7 ENO2 CHGA
12	merkel cell carcinoma	31.5	SYP NKX2-1 NCAM1 KRT7 ENO2 CHGA
13	lung large cell carcinoma	31.4	SYP NKX2-1 NCAM1 KRT7 ENO2 CHGA
14	prostate cancer	31.3	XAGE1B XAGE1A PTEN PDPK1 MSR1 HOXB13
15	carcinoid tumors, intestinal	31.2	SYP NKX2-1 ENO2 CHGA
16	lung oat cell carcinoma	31.2	SYP PTEN ENO2 CHGA
17	carcinoid syndrome	31.1	SYP ENO2 CHGA
18	gallbladder adenocarcinoma	31.1	SYP KRT7 CHGA
19	neuroendocrine tumor	31.0	SYP NKX2-1 NCAM1 ENO2 CHGA
20	neuroendocrine carcinoma	30.9	SYP PTEN NKX2-1 NCAM1 KRT7 ENO2
21	suppression of tumorigenicity 12	30.8	SYP PTEN MYCN ENO2 CHGA
22	large cell carcinoma	30.7	SYP NKX2-1 KRT7 ENO2 CHGA
23	diffuse gastric cancer	30.7	PTEN MSR1 CHEK2
24	carcinosarcoma	30.6	SYP PTEN KRT7
25	adenosquamous carcinoma	30.6	NKX2-1 KRT7 CHGA
26	large cell neuroendocrine carcinoma	30.6	SYP NKX2-1 NCAM1 KRT7 ENO2 CHGA
27	appendix adenocarcinoma	30.5	SYP KRT7 CHGA
28	serous cystadenocarcinoma	30.5	PTEN KRT7 HNF1B
29	rhabdomyosarcoma 2	30.5	SYP NCAM1 MYCN ENO2
30	thyroid gland medullary carcinoma	30.5	SYP NKX2-1 CHGA
31	adenoid cystic carcinoma	30.4	PTEN NCAM1 MYCN KRT7 CHEK2
32	lung benign neoplasm	30.4	SYP NKX2-1 NCAM1 KRT7 ENO2 CHGA
33	ewing sarcoma	30.4	SYP NCAM1 MYCN ENO2 CHGA
34	adrenal carcinoma	30.4	SYP ENO2 CHGA
35	teratoma	30.3	SYP PTEN NKX2-1 KRT7 ENO2 CHGA
36	pleomorphic carcinoma	30.3	NKX2-1 KRT7
37	mixed cell type cancer	30.3	SYP PTEN KRT7 ENO2 CHGA
38	breast ductal carcinoma	30.3	SYP PTEN KRT7 CHGA
39	trachea carcinoma	30.3	NKX2-1 KRT7
40	gastrointestinal stromal tumor	30.2	SYP PTEN NCAM1 ENO2 CHGA
41	islet cell tumor	30.2	SYP NCAM1 ENO2 CHGA
42	papillary carcinoma	30.2	NKX2-1 KRT7 CHGA
43	embryonal rhabdomyosarcoma	30.2	NCAM1 MYCN ENO2
44	thymic carcinoma	30.2	SYP NKX2-1 KRT7
45	pulmonary large cell neuroendocrine carcinoma	30.2	SYP NKX2-1 NCAM1 ENO2 CHGA
46	ectopic cushing syndrome	30.2	SYP CHGA
47	neuroblastoma	30.1	SYP PTEN NCAM1 MYCN ENO2 DDX1
48	horner's syndrome	30.1	SYP MYCN ENO2
49	tubular adenocarcinoma	30.1	SYP NCAM1 KRT7 ENO2 CHGA
50	lung combined large cell neuroendocrine carcinoma	30.1	SYP ENO2 CHGA

Graphical network of the top 20 diseases related to Small Cell Carcinoma:

Sources

Symptoms & Phenotypes for Small Cell Carcinoma

GenomeRNAi Phenotypes related to Small Cell Carcinoma according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability in pancreas lineage	GR00235-A	8.62	CHEK2 KRT7

MGI Mouse Phenotypes related to Small Cell Carcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.73	CHEK2 CHGA ENO2 HOXB13 MSR1 MYCN
2	mortality/aging	MP:0010768	9.47	CHEK2 CHGA DDX1 ENO1 HNF1B HOXB13

Sources

Drugs & Therapeutics for Small Cell Carcinoma

Drugs for Small Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 226)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

BCG vaccine

Approved, Investigational

Phase 3

Atezolizumab

Approved, Investigational

Phase 2, Phase 3

1380723-44-3

Picropodophyllin

Approved, Investigational

Phase 2, Phase 3

518-28-5, 477-47-4

10607 72435

Memantine

Approved, Investigational

Phase 3

41100-52-1, 19982-08-2

4054

Dopamine

Approved

Phase 3

62-31-7, 51-61-6

681

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 2, Phase 3

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 2, Phase 3

50-02-2

3003 5743

Ichthammol

Approved

Phase 2, Phase 3

8029-68-3

Mecobalamin

Approved, Investigational

Phase 2, Phase 3

13422-55-4

Hydroxocobalamin

Approved

Phase 2, Phase 3

13422-51-0

15589840 44475014

Bevacizumab

Approved, Investigational

Phase 3

216974-75-3

135329020

Osimertinib

Approved

Phase 3

1421373-65-0

71496458

Cisplatin

Approved

Phase 3

15663-27-1

2767 5702198 441203

Carboplatin

Approved

Phase 3

41575-94-4

10339178 38904

Etoposide

Approved

Phase 3

33419-42-0

36462

Cyanocobalamin

Approved, Nutraceutical

Phase 2, Phase 3

68-19-9

24892734 16212801 44176380

Camptothecin

Experimental

Phase 3

7689-03-4

24360

Belotecan

Investigational

Phase 3

256411-32-2

9824190

Cobalamin

Experimental

Phase 2, Phase 3

13408-78-1

6857388

Lexatumumab

Investigational

Phase 3

845816-02-6

Vaccines

Phase 3

Keratolytic Agents

Phase 2, Phase 3

Dermatologic Agents

Phase 2, Phase 3

Dopamine Agents

Phase 3

Antiparkinson Agents

Phase 3

Excitatory Amino Acid Antagonists

Phase 3

Vitamin B12

Phase 2, Phase 3

Vitamin B 12

Phase 2, Phase 3

Antiemetics

Phase 2, Phase 3

BB 1101

Phase 2, Phase 3

Gastrointestinal Agents

Phase 2, Phase 3

Endothelial Growth Factors

Phase 3

Immunoglobulins, Intravenous

Phase 3

Etoposide phosphate

Phase 3

16760419

Hematinics

Phase 3

Epoetin Alfa

Phase 3

Vorinostat

Approved, Investigational

Phase 1, Phase 2

149647-78-9

5311

Doxorubicin

Approved, Investigational

Phase 2

23214-92-8

31703

Arsenic trioxide

Approved, Investigational

Phase 2

1327-53-3

518740

Gefitinib

Approved, Investigational

Phase 2

184475-35-2

123631

Lenograstim

Approved, Investigational

Phase 2

135968-09-1

Azacitidine

Approved, Investigational

Phase 2

320-67-2

9444

Somatostatin

Approved, Investigational

Phase 1, Phase 2

38916-34-6, 51110-01-1

53481605 16129706

Temozolomide

Approved, Investigational

Phase 2

85622-93-1

5394

Sargramostim

Approved, Investigational

Phase 2

123774-72-1

Trastuzumab

Approved, Investigational

Phase 1, Phase 2

180288-69-1

Lamivudine

Approved, Investigational

Phase 2

134678-17-4

60825

Melphalan

Approved

Phase 1, Phase 2

148-82-3

4053 460612

Infliximab

Approved

Phase 1, Phase 2

170277-31-3

Vedolizumab

Approved

Phase 1, Phase 2

943609-66-3

Interventional clinical trials:

(show top 50) (show all 338)

#	Name	Status	NCT ID	Phase	Drugs
1	International Multi-center Open-label Randomized Clinical Trial of Efficacy, Safety and Pharmacokinetics of BCD-100 (JSC "BIOCAD", Russia) Monotherapy Compared to Docetaxel as Second-line Therapy of Patients With Advanced Inoperable or Metastatic Non-small Cell Lung Cancer	Unknown status	NCT03288870	Phase 2, Phase 3	BCD-100;Docetaxel
2	Phase III Randomized Study of Hypofractionated vs Conventionally Fractionated Concurrent Chemo-radiotherapy for Limited Disease Small Cell Lung Cancer	Unknown status	NCT02688036	Phase 3
3	A PHASE III STUDY OF ADJUVANT CHEMOTHERAPY AFTER RESECTION FOR PATIENTS WITH T2N0 STAGE I NON-SMALL CELL CARCINOMA OF THE LUNG	Completed	NCT00002852	Phase 3	paclitaxel;carboplatin
4	Randomized Trial of Mediastinal Lymph Node Sampling Versus Complete Lymphadenectomy During Pulmonary Resection in the Patient With N0 and N1 (Less Than Hilar) Non-Small Cell Carcinoma	Completed	NCT00003831	Phase 3
5	A Randomized Prospective Multicenter Trial of Belotecan/Cisplatin Versus Etoposide/Cisplatin in Patients With Previously Untreated, Extensive-stage Small-cell Lung Cancer	Completed	NCT00826644	Phase 3	Belotecan;Etoposide;Cisplatin
6	The SILVA Study: Survival in an International Phase III Prospective Randomized LD Small Cell Lung Cancer Vaccination Study With Adjuvant BEC2 and BCG	Completed	NCT00037713	Phase 3
7	A Placebo-Controlled Study on the Effect of Epoetin Alfa in Patients With Malignancy Receiving Chemotherapy	Completed	NCT00270166	Phase 3	epoetin alfa
8	Randomized Phase III Study of Combination Osimertinib (AZD9291) and Bevacizumab Versus Osimertinib (AZD9291) Alone as First-Line Treatment for Patients With Metastatic EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC)	Recruiting	NCT04181060	Phase 3	Osimertinib
9	MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)	Recruiting	NCT04155034	Phase 3
10	Integration of Immunotherapy Into Adjuvant Therapy for Resected NSCLC: ALCHEMIST Chemo-IO (ACCIO)	Recruiting	NCT04267848	Phase 3	Carboplatin;Cisplatin;Gemcitabine Hydrochloride;Paclitaxel;Pemetrexed Disodium
11	Randomized Phase III Trial of MEDI4736 (Durvalumab) as Concurrent and Consolidative Therapy or Consolidative Therapy Alone for Unresectable Stage 3 NSCLC	Recruiting	NCT04092283	Phase 3	Carboplatin;Cisplatin;Etoposide;Paclitaxel;Pemetrexed Disodium
12	A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy With or Without SBRT for PD-L1-Negative, Advanced Non-Small Cell Lung Cancer	Recruiting	NCT04929041	Phase 2, Phase 3	Carboplatin;Nab-paclitaxel;Paclitaxel;Pemetrexed
13	Phase III Trial of Stereotactic Radiosurgery (SRS) Versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for 10 or Fewer Brain Metastases From Small Cell Lung Cancer	Recruiting	NCT04804644	Phase 3	Memantine Hydrochloride
14	A Phase II/III Study of N-803 (ALT-803) Plus Pembrolizumab Versus Standard of Care in Participants With Stage IV or Recurrent Non-Small Cell Lung Cancer Previously Treated With Anti-PD-1 or Anti-PD-L1 Therapy (Lung-MAP Non-Match Sub-Study)	Recruiting	NCT05096663	Phase 2, Phase 3	Dexamethasone;Docetaxel;Gemcitabine;Nogapendekin Alfa;Pemetrexed
15	Limited Stage Small Cell Lung Cancer (LS-SCLC): A Phase III Randomized Study of Chemoradiation Versus Chemoradiation Plus Atezolizumab	Recruiting	NCT03811002	Phase 2, Phase 3	Atezolizumab;Carboplatin;Cisplatin;Etoposide
16	EA5163/S1709 INSIGNA : A Randomized, Phase III Study of Firstline Immunotherapy Alone or in Combination With Chemotherapy in Induction/Maintenance or Postprogression in Advanced Nonsquamous Non-Small Cell Lung Cancer (NSCLC) With Immunobiomarker SIGNature-Driven Analysis	Recruiting	NCT03793179	Phase 3	Carboplatin;Pemetrexed
17	Role of Radiotherapy to the Primary Lesion in Metastatic Non-small Cell Lung Cancer Patients After First Line Systemic Therapy	Recruiting	NCT04776083	Phase 3	first line systemic therapy
18	PD-1 Inhibitor and Chemotherapy With Concurrent Irradiation at Varied Tumour Sites in Advanced Non-small Cell Lung Cancer	Recruiting	NCT03774732	Phase 3	Pembrolizumab;Chemotherapy
19	Phase III Trial of Salvage Stereotactic Radiosurgery (SRS) or SRS + Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for First or Second Distant Brain Relapse After Upfront SRS With Brain Metastasis Velocity >/= 4 Brain Metastases/Year	Recruiting	NCT04588246	Phase 3	Memantine
20	A Randomized Phase III Trial of Induction/Consolidation Atezolizumab (NSC #783608) + SBRT Versus SBRT Alone in High Risk, Early Stage NSCLC	Recruiting	NCT04214262	Phase 3	Atezolizumab
21	Randomized Phase III Trial of Local Consolidation Therapy (LCT) After Nivolumab and Ipilimumab for Immunotherapy-Naive Patients With Metastatic Non-Small Cell Lung Cancer (LONESTAR)	Recruiting	NCT03391869	Phase 3
22	Randomized Phase II/III Trial of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR Trial	Recruiting	NCT04402788	Phase 2, Phase 3	Atezolizumab
23	Randomized Phase II/III Trial of First Line Platinum/Etoposide With or Without Atezolizumab (NSC#783608) in Patients With Poorly Differentiated Extrapulmonary Small Cell Neuroendocrine Carcinomas (NEC)	Recruiting	NCT05058651	Phase 2, Phase 3	Carboplatin;Cisplatin;Etoposide
24	Randomized Study of Erlotinib vs Observation in Patients With Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-Small Cell Lung Cancer (NSCLC)	Active, not recruiting	NCT02193282	Phase 3	Erlotinib Hydrochloride
25	Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) - A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers	Active, not recruiting	NCT02595944	Phase 3
26	A Phase III Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab for Patients With Completely Resected Stage IB (≥ 4 cm) - IIIA Non-small Cell Lung Cancer (NSCLC)	Active, not recruiting	NCT00324805	Phase 3	Cisplatin;Docetaxel;Gemcitabine Hydrochloride;Pemetrexed Disodium;Vinorelbine Tartrate
27	Qualitative Study on Experiences Related to Anorexia and the Effects of Anamorelin and Placebo in Advanced Non-Small-Cell Lung Cancer Patients With Anorexia-Cachexia: A Preliminary Study	Active, not recruiting	NCT03637816	Phase 2, Phase 3	Anamorelin Hydrochloride
28	REPLATINUM: A Phase 3, Controlled, Open-label, Global Randomized Study of RRx-001 Administered Sequentially With a Platinum Doublet or a Platinum Doublet in Third-Line or Beyond Small Cell Lung Cancer	Active, not recruiting	NCT05566041	Phase 3	RRx-001 + eLOOP Device;Cisplatin/carboplatin plus etoposide
29	Phase III Prospective Randomized Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally Advanced Non-Small Cell Lung Cancer	Not yet recruiting	NCT05624996	Phase 3	Carboplatin;Cisplatin;Etoposide;Paclitaxel;Pemetrexed
30	Phase III Study Comparing Osimertinib Monotherapy to Combination Therapy With Osimertinib,Carboplatin and Pemetrexed for Untreated Patients With Advanced Non-squamous Non-Small Cell Lung Cancer With Concurrent EGFR and TP53 Mutations	Not yet recruiting	NCT04695925	Phase 3	Osimertinib 80 MG [Tagrisso];Pemetrexed 500 MG Injection;Carboplatin
31	Pragmatica-Lung: A Prospective Randomized Study of Ramucirumab (LY3009806; NSC 749128) Plus Pembrolizumab (MK-3475; NSC 776864) Versus Standard of Care for Participants Previously Treated With Immunotherapy for Stage IV or Recurrent Non-Small Cell Lung Cancer	Not yet recruiting	NCT05633602	Phase 3	Chemotherapy
32	Randomized Trial of Epoetin Alfa in Patients With Advanced Non-Small Cell Carcinoma of the Lung (EPO-CAN-20)	Terminated	NCT00310232	Phase 3	Epoetin Alfa
33	A Phase 3, Controlled, Open-label, Randomized Study of RRx-001 Administered Sequentially With a Platinum Doublet or a Platinum Doublet in Third-Line or Beyond Small Cell Lung Cancer	Terminated	NCT03699956	Phase 3	Cisplatin/carboplatin plus etoposide
34	A Randomized, Phase III Dose Response Study of Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Lung	Withdrawn	NCT00006344	Phase 3
35	The Effect Of Aspirin On Survival Following Potentially Curative Resection Of Non Small Cell Carcinoma Of The Lung The Big A Trial	Withdrawn	NCT01058902	Phase 3	Aspirin 75 mg
36	Prospective Phase II Trial of a Combination of Gemcitabine and UFT as First-Line Treatment in Elderly Patients With Advanced Non-Small Cell Carcinoma	Unknown status	NCT00625352	Phase 2	Gemcitabine, UFT
37	Phase I/II Study of Vorinostat and Gefitinib in Relapsed/ or Refractory Patients With Advanced Non-small Cell Carcinoma (NSCLC)	Unknown status	NCT01027676	Phase 1, Phase 2	Study treatment
38	Phase II Study of Surgery Combined With Recombinant Adenoviral Human p53 Gene Therapy in Treatment Advanced Non-small-cell Carcinoma	Unknown status	NCT01574729	Phase 2	Surgery combined with rAd-p53 gene therapy
39	Phase II Clinical Trial of Toripalimab (JS001), a Recombinant Humanized Anti-PD-1 Monoclonal PD1 Antibody, as Monotherapy for Patients With Small Cell Esophageal Carcinoma Who Failed Chemotherapy	Unknown status	NCT03811379	Phase 2	Toripalimab
40	Phase Ⅱ Study of Relationship Between UGT1A1 Gene Polymorphism and Toxicity and Efficacy of Irinotecan in Small Cell Lung Cancer	Unknown status	NCT01635400	Phase 2	Irinotecan
41	Phase 2 Study of Temozolomide as Maintenance Therapy After Initial Induction Chemotherapy in Small Cell Lung Cancer	Unknown status	NCT01900951	Phase 2	Temozolomide
42	Combination Chemotherapy With or Without Maintenance Sunitinib Malate (NSC 736511) for Untreated Extensive Stage Small Cell Lung Cancer: A Phase IB/Randomized Phase II Study	Completed	NCT00453154	Phase 1, Phase 2	Carboplatin;Cisplatin;Etoposide;Sunitinib Malate
43	A Phase II Trial of Erlotinib and Concurrent Palliative Thoracic Radiation Therapy for Patients With Non-small Cell Carcinoma of the Lung. (PEARL Trial)	Completed	NCT00391248	Phase 2	Erlotinib
44	A Pilot Phase II Protocol Of Arsenic Trioxide (Trisenox) In Subjects With Advanced Non-Small Cell Carcinoma Of The Lung	Completed	NCT00075426	Phase 2	arsenic trioxide
45	A Randomized Trial of Pivanex Plus Docetaxel or Docetaxel Monotherapy in Patients With Chemotherapy Resistant Advanced Non-Small Cell Carcinoma of the Lung (NSCLC)	Completed	NCT00073385	Phase 2	Pivanex;Docetaxel
46	Phase I/II Trial of Infusional Gemcitabine in Combination With Carboplatin in Chemonaive Non-small Cell Carcinoma	Completed	NCT00212043	Phase 2	carboplatin and gemcitabine
47	LCCC 0215: Induction Chemotherapy Using Paclitaxel, Carboplatin, CPT-11 With Pegfilgrastim Support Followed by Conformal Radiotherapy and Paclitaxel/Carboplatin/ZD1839 in Locally Advanced Unresectable Stage IIIA/B Non-Small Cell Carcinoma of the Lung	Completed	NCT00280787	Phase 2	Paclitaxel;Carboplatin;CPT-11;Pegfilgrastim
48	A Phase II Study of RRx-001 in Platinum Refractory/Resistant Small Cell Carcinoma, EGFR TKI Resistant EGFR+ T790M Negative Non-Small Cell Lung Cancer, High Grade Neuroendocrine Tumors and Resistant/Refractory Ovarian Cancer Prior to Re-administration of Platinum Based Doublet Regimens (QUADRUPLE THREAT)	Completed	NCT02489903	Phase 2	RRx-001;Cisplatin;Etoposide;Carboplatin;Irinotecan;Vinorelbine;Doxil;Gemcitabine;Taxane;Paclitaxel;Nab-Paclitaxel;Pemetrexed
49	Utility of Preoperative FDG-PET/CT Scanning Prior to Primary Chemoradiation Therapy to Detect Retroperitoneal Lymph Node Metastasis in Patients With Locoregionally Advanced Carcinoma of the Cervix (IB2, IIA ≥ 4 CM, IIB-IVA) or Endometrium (Grade 3 Endometrioid Endometrial Carcinoma; Serous Papillary Carcinoma, Clear Cell Carcinoma, or Carcinosarcoma (Any Grade); and Grade 1 OR 2 Endometrioid Endometrial Carcinoma With Cervical Stromal Involvement Overt in Clinical Examination or Confirmed by Endocervical Curettage	Completed	NCT00416455	Phase 1, Phase 2	ferumoxtran-10
50	Pilot Study to Evaluate the Effect of Intrapleural Docetaxel Administration Using Medical Pleuroscopy in Malignant Effusion With Lung Cancer	Completed	NCT03394105	Phase 2	intrapleural docetaxel administration

Search NIH Clinical Center for Small Cell Carcinoma

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Cisplatin

CISPLATIN PWDR

Teniposide

Topotecan

Topotecan Hydrochloride

Sources

Genetic Tests for Small Cell Carcinoma

Sources

Anatomical Context for Small Cell Carcinoma

Organs/tissues related to Small Cell Carcinoma:

MalaCards : Lung, Cervix, Prostate, Lymph Node, Brain, Bone Marrow, Ovary

Sources

Publications for Small Cell Carcinoma

Articles related to Small Cell Carcinoma:

(show top 50) (show all 7281)

#	Title	Authors	PMID	Year
1	Small-Cell Carcinoma of Nasopharynx: A Case Report of Unusual Localization. ⁶²	Mesolella M...Motta G	33371727	2023
2	Opium use and risk of lung cancer: A multicenter case-control study in Iran. ⁶²	Rashidian H...Zendehdel K	36043555	2023
3	Small-cell neuroendocrine carcinoma of the vagina: A case report. ⁶²	Kalampokas E...Marinis S	36453163	2022
4	Influence of ABO blood group on susceptibility to different pathological types of lung cancer: a retrospective study. ⁶²	Yang H...Zhong N	36464709	2022
5	Surgical resection combined with perioperative chemotherapy for a patient with locally recurrent, previously stage IV thymic small-cell carcinoma: A case report. ⁶²	Terada J...Shinohara T	36345130	2022
6	ASO Visual Abstract: Prognostic Factors and Survival in Gastrointestinal Extrapulmonary Small Cell Carcinoma-A Retrospective Cohort Study. ⁶²	Ulanja MB...Alese OB	36036843	2022
7	ASO Author Reflections: Prognostic Factors in Gastrointestinal Extrapulmonary Small Cell Carcinoma Using Real-World Data. ⁶²	Ulanja MB...Alese OB	36006493	2022
8	Limited-stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study. ⁶²	Gu YM...Chen LQ	36036894	2022
9	Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): A review and novel case with dual germline SMARCA4 and BRCA2 mutations. ⁶²	Sanders BE...Brubaker LW	36249907	2022
10	Prognostic Factors and Survival in Gastrointestinal Extrapulmonary Small Cell Carcinoma: A Retrospective Cohort Study. ⁶²	Ulanja MB...Alese OB	35978206	2022
11	Prostate cancer recurring as small-cell carcinoma with a BRCA2 somatic mutation. ⁶²	Yabusaki R...Suzuki M	36341199	2022
12	Real-world experience managing unresectable or metastatic small cell carcinoma of the prostate. ⁶²	Ko JJ...Parimi S	35704939	2022
13	Leptomeningeal carcinomatosis in small cell carcinoma of the prostate. ⁶²	Fukuta K...Kanayama HO	36341201	2022
14	Sequential small cell transformation and T790M mutation in an epidermal growth factor-mutant lung adenocarcinoma: A rare occurrence with significant management implications. ⁶²	Shastri M...Khosla D	35867808	2022
15	[Two Cases of TKI-resistant Small Cell Lung Cancer Transformation  in Advanced Adenocarcinoma and Literature Review]. ⁶²	Wu J...Wang H	36419397	2022
16	Small Cell and Other Rare Histologic Types of Cervical Cancer. ⁶²	Marchocki Z...Covens A	35947285	2022
17	NOL4 is a novel nuclear marker of small cell carcinoma and other neuroendocrine neoplasms. ⁶²	Lee JH...Kim JY	36282054	2022
18	Small Biopsy and Cytology of Pulmonary Neuroendocrine Neoplasms: Brief Overview of Classification, Immunohistochemistry, Molecular Profiles, and World Health Organization Updates. ⁶²	Sung S...Saqi A	36053019	2022
19	[Clinical analysis of 12 cases of laryngeal neuroendocrine carcinoma]. ⁶²	Xu NW...Zhao CQ	36404660	2022
20	Cutaneous metastases of non-cutaneous neuroendocrine neoplasms: A histopathologic review of 15 cases. ⁶²	Hobbs MM...Sokumbi O	36222210	2022
21	RhoA and vigilin are candidates for immunohistochemical markers for epithelioid malignant mesothelioma. ⁶²	Hiratsuka T...Tsuruyama T	36323745	2022
22	[Early onset of small cell carcinom of the lung in a young patient in Benin]. ⁶²	Fiogbe A...Agodokpessi G	36088182	2022
23	Cardiac metastasis from small cell lung cancer origin: A case report and review of the literature. ⁶²	Tian L...Zhang H	36117246	2022
24	Metastatic lung carcinoma in thyroid aspirates: A case series and literature review illustrating diagnostic challenges. ⁶²	Ng JKM...Li JJX	35808980	2022
25	Low-grade tracheal adenocarcinoma with ETV6::NTRK3 fusion: unique morphology akin to subsets of sinonasal low-grade non-intestinal-type adenocarcinoma. ⁶²	Kishikawa S...Yao T	35670854	2022
26	Patterns of Extrathoracic Metastasis in Lung Cancer Patients. ⁶²	Park HK...Bae GE	36421344	2022
27	Lung cancer incidence attributable to residential radon exposure in Finland. ⁶²	Kurkela O...Auvinen A	36344858	2022
28	Oral formulation of bendamustine hydrochloride for patients with advanced solid tumors; a phase 1 study. ⁶²	Shimizu T...Takeda M	36331674	2022
29	Immunosensitivity and specificity of insulinoma-associated protein 1 (INSM1) for neuroendocrine neoplasms of the uterine cervix. ⁶²	Kuji S...Suzuki N	36245222	2022
30	[Study on the relationship between the pathological type of lung cancer caused by coke oven discharge and the contact type and exposure time]. ⁶²	Wang LL...He YP	36348558	2022
31	TENS Improves Cisplatin-Induced Neuropathy in Lung Cancer Patients. ⁶²	Tomanovic Vujadinovic S...Jovanovic D	36295566	2022
32	Small cell neuroendocrine carcinoma of vagina: Report of a unique case with literature review. ⁶²	Pongsuvareeyakul T...Singh K	36274474	2022
33	Semi-Supervised Adversarial Learning for Improving the Diagnosis of Pulmonary Nodules. ⁶²	Fu Y...Dong E	36269913	2022
34	A case report of pulmonary combined small cell carcinoma with enteric adenocarcinoma. ⁶²	Wang S...Li B	36388049	2022
35	Metastatic prostate cancer diagnosed by fine needle aspiration: Contemporary cytopathologic and biomarker assessment with clinical correlates. ⁶²	Cantley RL...Mehra R	36264673	2022
36	Cytomorphology, immunoprofile, and clinicopathologic correlation of metastatic prostatic carcinoma. ⁶²	Lin X...Yang XJ	36244466	2022
37	Preoperative Chemotherapy for Limited-stage Small Cell Carcinoma of the Esophagus. ⁶²	Cai G...Chen Y	34610332	2022
38	Surgical treatment of intermediate to high grade thymic neuroendocrine neoplasms: case series of five patients and literature review. ⁶²	Huang C...Tong HF	36388024	2022
39	Atypical Carcinoid Syndrome in a Patient Presenting With Pericarditis and Supraventricular Tachycardia: A Case Report. ⁶²	Khan Z...Patel N	36381843	2022
40	Comprehensive genomic profiling of Finnish lung adenocarcinoma cohort reveals high clinical actionability and SMARCA4 altered tumors with variable histology and poor prognosis. ⁶²	Talvitie EM...Taimen P	35964518	2022
41	Small Cell Carcinoma of Ovary, Hypercalcemic Type: A Rare Case Report. ⁶²	Coskun C...Kutluk T	36243275	2022
42	Lymphadenectomy Benefits Small Cell Carcinoma of Ovary: A Population-Based Analysis. ⁶²	Wang J...Kang Y	36290894	2022
43	Small Cell Carcinoma of the Vagina: First Systematic Review of Case Reports and Proposal of a Management Algorithm. ⁶²	Capote S...Romeo M	36282979	2022
44	Long-term Outcomes of Local and Metastatic Small Cell Carcinoma of the Urinary Bladder and Genomic Analysis of Patients Treated With Neoadjuvant Chemotherapy. ⁶²	Teo MY...Al-Ahmadie H	35676169	2022
45	Fulminant Myocarditis for Non-small-cell Carcinoma of the Lung with Nivolumab and Ipilimumab Plus Chemotherapy: A Case Report. ⁶²	Nishimura T...Kiura K	36130891	2022
46	Small-cell carcinoma of the gall bladder: Report of three cases and review of the literature. ⁶²	Pandey L...Gupta M	36147409	2022
47	Umbilical metastasis as an initial presentation of gastrointestinal stromal tumour diagnosed on aspiration cytology. ⁶²	Kundu R...Dey P	35689547	2022
48	Diagnostic accuracy and adequacy of peripheral pulmonary nodules samples obtained by transthoracic needle aspiration. ⁶²	Lovrenski A...Miljkovic D	36062401	2022
49	Transformation from lung adenocarcinoma to combined small cell carcinoma in pleural effusion after treatment with osimertinib. ⁶²	Frankel D...Roll P	35689552	2022
50	Clinical characteristics and treatment outcomes of patients with small cell carcinoma of the urinary bladder. ⁶²	Muranaka T...Masumori N	36204354	2022

Sources

Genes for Small Cell Carcinoma

Genes related to Small Cell Carcinoma (0 elite genes):

(show all 37)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PTEN	Phosphatase And Tensin Homolog	Protein Coding	21.79	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
2	MYCN	MYCN Proto-Oncogene, BHLH Transcription Factor	Protein Coding	20.68	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Functions (show sections)
3	ENO1	Enolase 1	Protein Coding	19.24	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Proteins (show sections)
4	DDX1	DEAD-Box Helicase 1	Protein Coding	14.86	GeneCards inferred via : Publications Functions (show sections)
5	CHEK2	Checkpoint Kinase 2	Protein Coding	11.86	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
6	HOXB13	Homeobox B13	Protein Coding	11.7	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
7	HNF1B	HNF1 Homeobox B	Protein Coding	11.08	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
8	XAGE1A	X Antigen Family Member 1A	Protein Coding	10.66	DISEASES inferred ¹⁴ GeneCards inferred via : Expressions (show sections)
9	XAGE1B	X Antigen Family Member 1B	Protein Coding	10.66	DISEASES inferred ¹⁴ GeneCards inferred via : Expressions (show sections)
10	MSR1	Macrophage Scavenger Receptor 1	Protein Coding	10.43	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
11	SYP	Synaptophysin	Protein Coding	8.82	DISEASES inferred ¹⁴
12	ENO2	Enolase 2	Protein Coding	8.57	DISEASES inferred ¹⁴
13	CHGA	Chromogranin A	Protein Coding	8.38	DISEASES inferred ¹⁴
14	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	8.12	DISEASES inferred ¹⁴
15	NKX2-1	NK2 Homeobox 1	Protein Coding	8.09	DISEASES inferred ¹⁴
16	AGAP2-AS1	AGAP2 Antisense RNA 1	RNA Gene	7.52	GeneCards inferred via : Summaries (show sections)
17	KDM3B	Lysine Demethylase 3B	Protein Coding	7.52	GeneCards inferred via : Summaries (show sections)
18	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	7.52	GeneCards inferred via : Summaries (show sections)
19	TENT5A	Terminal Nucleotidyltransferase 5A	Protein Coding	7.52	GeneCards inferred via : Summaries (show sections)
20	KRT7	Keratin 7	Protein Coding	7.51	DISEASES inferred ¹⁴
21	EHBP1	EH Domain Binding Protein 1	Protein Coding	7.5	GeneCards inferred via : Disorders (show sections)
22	ELAC2	ElaC Ribonuclease Z 2	Protein Coding	7.5	GeneCards inferred via : Disorders (show sections)
23	EPHB2	EPH Receptor B2	Protein Coding	7.5	GeneCards inferred via : Disorders (show sections)
24	KLF6	KLF Transcription Factor 6	Protein Coding	7.5	GeneCards inferred via : Disorders (show sections)
25	MSMB	Microseminoprotein Beta	Protein Coding	7.5	GeneCards inferred via : Disorders (show sections)
26	MXI1	MAX Interactor 1, Dimerization Protein	Protein Coding	7.5	GeneCards inferred via : Disorders (show sections)
27	RNASEL	Ribonuclease L	Protein Coding	7.5	GeneCards inferred via : Disorders (show sections)
28	SMARCA4	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4	Protein Coding	7.48	DISEASES inferred ¹⁴
29	GRP	Gastrin Releasing Peptide	Protein Coding	7.33	DISEASES inferred ¹⁴
30	NAPSA	Napsin A Aspartic Peptidase	Protein Coding	7.27	DISEASES inferred ¹⁴
31	TP53	Tumor Protein P53	Protein Coding	7.22	DISEASES inferred ¹⁴
32	EGFR	Epidermal Growth Factor Receptor	Protein Coding	7.19	DISEASES inferred ¹⁴
33	KRT20	Keratin 20	Protein Coding	7.16	DISEASES inferred ¹⁴
34	KRT5	Keratin 5	Protein Coding	7.14	DISEASES inferred ¹⁴
35	SDCBP	Syndecan Binding Protein	Protein Coding	6.98	GeneCards inferred via : Expressions (show sections)
36	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	6.93	DISEASES inferred ¹⁴
37	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	6.89	DISEASES inferred ¹⁴

Sources

Variations for Small Cell Carcinoma

Sources

Expression for Small Cell Carcinoma

Search GEO for disease gene expression data for Small Cell Carcinoma.

Sources

Pathways for Small Cell Carcinoma

Pathways related to Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ³	11.89	SYP NKX2-1 NCAM1 MYCN ENO2
2	Clear cell renal cell carcinoma pathways ⁷⁴	11.26	PTEN ENO2 ENO1
3	GDNF signaling ⁷⁴	11.14	SYP PTEN PDPK1 NCAM1 MYCN