Small-Cell Carcinoma of the Ovary of Hypercalcemic Type disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SML041 MIFTS: 35	Small-Cell Carcinoma of the Ovary of Hypercalcemic Type Categories: Cancer diseases, Endocrine diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

MalaCards integrated aliases for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type:

Name: Small-Cell Carcinoma of the Ovary of Hypercalcemic Type ¹² ¹⁵

Small Cell Carcinoma of the Ovary, Hypercalcemic Type ⁶

Hypercalcemic Type Ovarian Small Cell Carcinoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7651

NCIt ⁵⁰ C40439

UMLS ⁷¹ C1518736

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Summaries for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Disease Ontology : ¹² An ovarian small cell carcinoma that is associated with paraneoplastic hypercalcemia.

MalaCards based summary : Small-Cell Carcinoma of the Ovary of Hypercalcemic Type, also known as small cell carcinoma of the ovary, hypercalcemic type, is related to ovarian small cell carcinoma and rhabdoid cancer. An important gene associated with Small-Cell Carcinoma of the Ovary of Hypercalcemic Type is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Gastric cancer and BRCA1 Pathway. Affiliated tissues include ovary, uterus and cervix, and related phenotypes are Decreased TP53 mRNA expression and Decreased TP53 mRNA expression

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Related Diseases for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Diseases related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)

#	Related Disease	Score	Top Affiliating Genes
1	ovarian small cell carcinoma	31.2	SMARCA4 MSANTD2
2	rhabdoid cancer	30.5	TP53 SMARCA4
3	rare tumor	10.7
4	small cell carcinoma	10.6
5	rhabdoid tumor predisposition syndrome 2	10.3
6	atypical teratoid rhabdoid tumor	10.3
7	li-fraumeni syndrome	10.3
8	ovarian cancer	10.3
9	li-fraumeni syndrome 2	10.3
10	pelvic inflammatory disease	10.3
11	sarcoma	10.3
12	liposarcoma	10.3
13	spindle cell sarcoma	10.3
14	pleomorphic liposarcoma	10.3
15	juvenile type testicular granulosa cell tumor	10.3
16	47,xyy	10.3
17	uterine sarcoma	10.3
18	endometrioid ovary carcinoma	10.2	TP53 SMARCA4
19	ovarian clear cell adenocarcinoma	10.1	TP53 SMARCA4
20	choroid plexus cancer	10.1	TP53 SMARCA4
21	childhood medulloblastoma	10.1	TP53 SMARCA4
22	spinal canal and spinal cord meningioma	10.1	SMARCA4 DPF1
23	spinal meningioma	10.1	SMARCA4 DPF1
24	neuroblastoma 1	10.0	TP53 SMARCA4
25	neurilemmomatosis	10.0	SMARCA4 DPF1
26	burkitt lymphoma	9.8	TP53 BCL7C BCL7B
27	clark-baraitser syndrome	9.4	SS18L1 SMARCA4 DPF2 DPF1
28	autosomal dominant non-syndromic intellectual disability	8.7	TP53 SS18L1 SMARCD2 SMARCA4 DPF2 DPF1

Graphical network of the top 20 diseases related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type:

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Symptoms & Phenotypes for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

GenomeRNAi Phenotypes related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased TP53 mRNA expression	GR00389-S-5	9.13	TP53
2	Decreased TP53 mRNA expression	GR00389-S-6	9.13	SMARCD2 TP53
3	Increased Nanog expression	GR00371-A-1	9.02	DPF1 DPF2 SMARCA4
4	Increased Nanog expression	GR00371-A-2	9.02	DPF2
5	Increased Nanog expression	GR00371-A-3	9.02	DPF2

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Drugs & Therapeutics for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Search Clinical Trials , NIH Clinical Center for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

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Genetic Tests for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

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Anatomical Context for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

MalaCards organs/tissues related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type:

⁴⁰

Ovary, Uterus, Cervix

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Publications for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Articles related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type:

(show top 50) (show all 80)

#	Title	Authors	PMID	Year
1	Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases. ⁶¹	Holdhof D...Schuller U	33331994	2021
2	Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines. ⁶¹	Karnezis AN...Wang Y	33328126	2021
3	SMARCA4 (BRG1) and SMARCB1 (INI1) expression in TTF-1 negative neuroendocrine carcinomas including merkel cell carcinoma. ⁶¹	Gandhi JS...Gradowski JF	33581550	2021
4	Reprogramming of Nucleotide Metabolism Mediates Synergy between Epigenetic Therapy and MAP Kinase Inhibition. ⁶¹	Shorstova T...Witcher M	33087508	2021
5	Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism. ⁶¹	Orlando KA...Weissman BE	33355532	2020
6	Dose-intensive regimen treatment for small-cell carcinoma of the ovary of hypercalcemic type (SCCOHT). ⁶¹	Blanc-Durand F...Pautier P	32723678	2020
7	Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): Comprehensive management of a newly diagnosed young adult. ⁶¹	Pressey JG...Szabo S	32654763	2020
8	Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines. ⁶¹	Tischkowitz M...Weissman BE	32156746	2020
9	Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase-Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type. ⁶¹	Ji JX...Huntsman DG	32409304	2020
10	Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) beyond SMARCA4 Mutations: A Comprehensive Genomic Analysis. ⁶¹	Auguste A...Leary A	32575483	2020
11	Successful pregnancy following chemotherapy in a survivor of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): A case report and review of literature. ⁶¹	Phoolcharoen N...Schmeler K	32405521	2020
12	Optimal age for genetic cancer predisposition testing in hereditary SMARCA4 Ovarian Cancer Families: How young is too young? ⁶¹	Podwika SE...Modesitt SC	32382648	2020
13	Germline mutations of SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type and in SMARCA4-deficient undifferentiated uterine sarcoma: Clinical features of a single family and comparison of large cohorts. ⁶¹	Connor YD...Shea M	31954538	2020
14	Loss of BRG1 (SMARCA4) Immunoexpression in a Pediatric Non-Central Nervous System Tumor Cohort. ⁶¹	Saunders J...Bush J	31403913	2020
15	Small Cell Carcinoma of Ovary, Hypercalcemic Type (Malignant Rhabdoid Tumor of Ovary) with Loss of SMARCA4 (BRG1) Expression: Report of Two Cases. ⁶¹	Sahay A...Deodhar KK	32149361	2020
16	Mixed Serous and Clear Cell Adenocarcinoma of the Ovary Presenting with Symptomatic Hypercalcemia: A Case Report and Clinical Considerations. ⁶¹	Boland JL...Shahbazi SZ	32069206	2020
17	The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer. ⁶¹	Soldi R...Sharma S	32649682	2020
18	Combined CDK4/6 and PD-1 Inhibition in Refractory SMARCA4-Deficient Small-Cell Carcinoma of the Ovary, Hypercalcemic Type. ⁶¹	Lee EK...Konstantinopoulos PA	32704608	2020
19	[Pathological and molecular features of malignancies underlined by BAF complexes inactivation]. ⁶¹	Le Quang M...Le Loarer F	31255411	2019
20	SMARCA4 inactivation defines a subset of undifferentiated uterine sarcomas with rhabdoid and small cell features and germline mutation association. ⁶¹	Lin DI...Elvin JA	31190001	2019
21	Pembrolizumab-Induced Thyroiditis. ⁶¹	Imblum BA...LiVolsi VA	31111437	2019
22	The dilemma of early preventive oophorectomy in familial small cell carcinoma of the ovary of hypercalcemic type. ⁶¹	Pejovic T...Foulkes WD	30886884	2019
23	Ovarian small cell carcinoma in one of a pair of monozygous twins. ⁶¹	Fahiminiya S...Foulkes WD	30284660	2019
24	SMARCA4-deficient Thoracic Sarcomas: Clinicopathologic Study of 30 Cases With an Emphasis on Their Nosology and Differential Diagnoses. ⁶¹	Perret R...Le Loarer F	30451731	2019
25	The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting. ⁶¹	Pan J...Kadoch C	30858614	2019
26	CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary. ⁶¹	Xue Y...Huang S	30718512	2019
27	An In-Depth Look at Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT): Clinical Implications from Recent Molecular Findings. ⁶¹	Lu B...Shi H	30662543	2019
28	Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): a challenge for clinicopathological diagnosis. ⁶¹	Li R...Feng Z	31934039	2019
29	Histone Deacetylase Inhibitors Synergize with Catalytic Inhibitors of EZH2 to Exhibit Antitumor Activity in Small Cell Carcinoma of the Ovary, Hypercalcemic Type. ⁶¹	Wang Y...Huntsman DG	30232145	2018
30	SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications. ⁶¹	Fukumoto T...Zhang R	30037854	2018
31	Multimodal molecular analysis of an atypical small cell carcinoma of the ovary, hypercalcemic type. ⁶¹	David MP...Fisher KE	30275002	2018
32	Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Clinical and Imaging Review. ⁶¹	Korivi BR...Prasad SR	28943050	2018
33	SMARCA4-deficient undifferentiated uterine sarcoma (malignant rhabdoid tumor of the uterus): a clinicopathologic entity distinct from undifferentiated carcinoma. ⁶¹	Kolin DL...Howitt BE	29700418	2018
34	Two types of small cell carcinoma of the ovary: Two typical case reports. ⁶¹	Yoshida Y...Kato K	30094313	2018
35	Immune-Active Microenvironment in Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Rationale for Immune Checkpoint Blockade. ⁶¹	Jelinic P...Zamarin D	29365144	2018
36	Hereditary SWI/SNF complex deficiency syndromes. ⁶¹	Agaimy A...Foulkes WD	29397238	2018
37	Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition. ⁶¹	Lang JD...Trent JM	29440177	2018
38	Cytological features of small cell carcinoma of the ovary-hypercalcemic type/malignant ovarian rhabdoid tumor in ascitic fluid. ⁶¹	Lae M...Klijanienko J	29446248	2018
39	Identification of Driver Mutations in Rare Cancers: The Role of SMARCA4 in Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT). ⁶¹	Lang JD...Hendricks WPD	29423809	2018
40	Successful treatment of a stage IIIC small-cell carcinoma of the ovary hypercalcemic subtype using multi-modality therapeutic approach. ⁶¹	Qin Q...Singh M	29910829	2018
41	Comprehensive genomic profiling reveals inactivating SMARCA4 mutations and low tumor mutational burden in small cell carcinoma of the ovary, hypercalcemic-type. ⁶¹	Lin DI...Elvin JA	29102090	2017
42	Rhabdoid Tumor Predisposition Syndrome ⁶¹	Nemes K...Fruhwald MC	29215836	2017
43	Association of Li-Fraumeni Syndrome With Small Cell Carcinoma of the Ovary, Hypercalcemic Type and Concurrent Pleomorphic Liposarcoma of the Cervix. ⁶¹	Tandon B...Al-Kateb H	28177947	2017
44	SMARCA4 germline gene mutation in a patient with epithelial ovarian: A case report. ⁶¹	Muppala R...Schlumbrecht MP	29204511	2017
45	The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases. ⁶¹	Witkowski L...Foulkes WD	27866340	2017
46	Cancer Surveillance in Gorlin Syndrome and Rhabdoid Tumor Predisposition Syndrome. ⁶¹	Foulkes WD...Diller L	28620006	2017
47	Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models. ⁶¹	Chan-Penebre E...Ribich SA	28292935	2017
48	Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): A rare case after in vitro fertilization (IVF). ⁶¹	Ghazi A...Islam N	28367208	2017
49	SMARCA4-Deficient Carcinoma of Unknown Primary Presenting with Fatal Paraneoplastic Hypercalcemia in a Heart Transplant Recipient: First Report in a Male Patient. ⁶¹	Agaimy A...Strecker T	29158936	2017
50	Refractory Small Cell Carcinoma of the Ovary - Hypercalcemic Type (SCCOHT) Treated with Romidepsin and Topotecan: A Case Report and Review of the Literature. ⁶¹	Rao V...Vredenburgh JJ	29772136	2016

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Genes for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Genes related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TP53	Tumor Protein P53	Protein Coding	25	Likely pathogenic ⁶
2	SMARCA4	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4	Protein Coding	14.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	MSANTD2	Myb/SANT DNA Binding Domain Containing 2	Protein Coding	6.17	DISEASES inferred ¹⁵
4	BCL7C	BAF Chromatin Remodeling Complex Subunit BCL7C	Protein Coding	5.6	DISEASES inferred ¹⁵
5	BCL7B	BAF Chromatin Remodeling Complex Subunit BCL7B	Protein Coding	5.52	DISEASES inferred ¹⁵
6	TBC1D21	TBC1 Domain Family Member 21	Protein Coding	5.5	DISEASES inferred ¹⁵
7	DPF2	Double PHD Fingers 2	Protein Coding	5.41	DISEASES inferred ¹⁵
8	DPF1	Double PHD Fingers 1	Protein Coding	5.4	DISEASES inferred ¹⁵
9	SMARCD2	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily D, Member 2	Protein Coding	5.37	DISEASES inferred ¹⁵
10	SS18L1	SS18L1 Subunit Of BAF Chromatin Remodeling Complex	Protein Coding	5.35	DISEASES inferred ¹⁵
11	BICRAL	BRD4 Interacting Chromatin Remodeling Complex Associated Protein Like	Protein Coding	5.32	DISEASES inferred ¹⁵

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Variations for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

ClinVar genetic disease variations for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	TP53	NM_000546.5(TP53):c.594_611del (p.Gly199_Glu204del)	Deletion	Likely pathogenic	560921	rs1567551704	17:7578238-7578255	17:7674920-7674937

Cosmic variations for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type:

⁹ (show top 50) (show all 660)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM113486751	WT1	ovary,NS,carcinoma,small cell carcinoma	c.1240A>C	p.K414Q	11:32396266-32396266	6
2	COSM91385090	WT1	ovary,NS,carcinoma,small cell carcinoma	c.1240A>C	p.K414Q	11:32396266-32396266	6
3	COSM100783551	WT1	ovary,NS,carcinoma,small cell carcinoma	c.604A>C	p.K202Q	11:32396266-32396266	6
4	COSM111540839	WT1	ovary,NS,carcinoma,small cell carcinoma	c.1189A>C	p.K397Q	11:32396266-32396266	6
5	COSM147428189	WT1	ovary,NS,carcinoma,small cell carcinoma	c.1189A>C	p.K397Q	11:32396266-32396266	6
6	COSM130520647	WT1	ovary,NS,carcinoma,small cell carcinoma	c.553A>C	p.K185Q	11:32396266-32396266	6
7	COSM149741943	WT1	ovary,NS,carcinoma,small cell carcinoma	c.1240A>C	p.K414Q	11:32396266-32396266	6
8	COSM148595596	WT1	ovary,NS,carcinoma,small cell carcinoma	c.1240A>C	p.K414Q	11:32396266-32396266	6
9	COSM93210112	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.584T>A	p.I195N	17:7674947-7674947	6
10	COSM105626718	TP53	ovary,NS,carcinoma,small cell carcinoma	c.761T>A	p.I254N	17:7674202-7674202	6
11	COSM112265718	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.376-2A>G	p.?	17:7675238-7675238	6
12	COSM143944155	TP53	ovary,NS,carcinoma,small cell carcinoma	c.367C>T	p.R123W	17:7673776-7673776	6
13	COSM121883757	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.379G>T	p.D127Y	17:7674188-7674188	6
14	COSM144315359	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.658G>T	p.D220Y	17:7674188-7674188	6
15	COSM121876472	TP53	ovary,NS,carcinoma,small cell carcinoma	c.448C>T	p.R150W	17:7673776-7673776	6
16	COSM143377204	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.658G>T	p.D220Y	17:7674188-7674188	6
17	COSM87905712	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.775G>T	p.D259Y	17:7674188-7674188	6
18	COSM121890133	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.-23A>G	p.?	17:7675238-7675238	6
19	COSM112259562	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.775G>T	p.D259Y	17:7674188-7674188	6
20	COSM87929008	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.584T>A	p.I195N	17:7674947-7674947	6
21	COSM145017220	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.457C>T	p.Q153*	17:7674957-7674957	6
22	COSM144013113	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.491G>A	p.R164H	17:7675088-7675088	6
23	COSM106052835	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.574C>T	p.Q192*	17:7674957-7674957	6
24	COSM106065581	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.376-2A>G	p.?	17:7675238-7675238	6
25	COSM143384685	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.259-2A>G	p.?	17:7675238-7675238	6
26	COSM145027383	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.802+1G>T	p.?	17:7673700-7673700	6
27	COSM143370507	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.457C>T	p.Q153*	17:7674957-7674957	6
28	COSM122760210	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.188T>A	p.I63N	17:7674947-7674947	6
29	COSM93193704	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.919+1G>T	p.?	17:7673700-7673700	6
30	COSM111758217	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.818G>A	p.R273H	17:7673802-7673802	6
31	COSM143381454	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.802+1G>T	p.?	17:7673700-7673700	6
32	COSM143167165	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.-104A>G	p.?	17:7675238-7675238	6
33	COSM145017326	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.407G>A	p.R136H	17:7675088-7675088	6
34	COSM121875437	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.178C>T	p.Q60*	17:7674957-7674957	6
35	COSM122271291	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.128G>A	p.R43H	17:7675088-7675088	6
36	COSM142841840	TP53	ovary,NS,carcinoma,small cell carcinoma	c.761T>A	p.I254N	17:7674202-7674202	6
37	COSM144012970	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.541C>T	p.Q181*	17:7674957-7674957	6
38	COSM142846634	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.376-2A>G	p.?	17:7675238-7675238	6
39	COSM144650676	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.457C>T	p.Q153*	17:7674957-7674957	6
40	COSM112253051	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.574C>T	p.Q192*	17:7674957-7674957	6
41	COSM112253106	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.818G>A	p.R273H	17:7673802-7673802	6
42	COSM143943506	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.97C>T	p.Q33*	17:7674957-7674957	6
43	COSM111758876	TP53	ovary,NS,carcinoma,small cell carcinoma	c.844C>T	p.R282W	17:7673776-7673776	6
44	COSM122739712	TP53	ovary,NS,carcinoma,small cell carcinoma	c.365T>A	p.I122N	17:7674202-7674202	6
45	COSM143157023	TP53	ovary,NS,carcinoma,small cell carcinoma	c.367C>T	p.R123W	17:7673776-7673776	6
46	COSM145029876	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.259-2A>G	p.?	17:7675238-7675238	6
47	COSM111758247	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.524G>A	p.R175H	17:7675088-7675088	6
48	COSM143949177	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.298G>T	p.D100Y	17:7674188-7674188	6
49	COSM112259092	TP53	ovary,NS,carcinoma,small cell carcinoma	c.761T>A	p.I254N	17:7674202-7674202	6
50	COSM121887348	TP53	ovary,NS,carcinoma,undifferentiated carcinoma	c.523+1G>T	p.?	17:7673700-7673700	6

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Expression for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Search GEO for disease gene expression data for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type.

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Pathways for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Pathways related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	11.92	TP53 SMARCD2 SMARCA4 DPF1
2	BRCA1 Pathway ⁶³ Show member pathways Fanconi's Anaemia Pathway ⁶³	10.72	TP53 SMARCD2 SMARCA4

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GO Terms for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Cellular components related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatin	GO:0000785	9.55	TP53 SMARCD2 SMARCA4 DPF2 DPF1
2	SWI/SNF complex	GO:0016514	9.13	SMARCD2 SMARCA4 BICRAL
3	nBAF complex	GO:0071565	8.92	SS18L1 SMARCA4 DPF2 DPF1

Biological processes related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.73	TP53 SS18L1 SMARCA4 BICRAL
2	negative regulation of transcription, DNA-templated	GO:0045892	9.62	TP53 SMARCA4 DPF2 DPF1
3	chromatin organization	GO:0006325	9.46	SS18L1 SMARCD2 SMARCA4 DPF2
4	positive regulation of pri-miRNA transcription by RNA polymerase II	GO:1902895	9.4	TP53 SMARCA4
5	ATP-dependent chromatin remodeling	GO:0043044	9.37	SMARCD2 SMARCA4
6	apoptotic process	GO:0006915	9.35	TP53 DPF2 DPF1 BCL7C BCL7B
7	nucleosome disassembly	GO:0006337	9.26	SMARCD2 SMARCA4
8	positive regulation of transcription by RNA polymerase II	GO:0045944	9.1	TP53 SS18L1 SMARCD2 SMARCA4 DPF2 DPF1

Molecular functions related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	histone binding	GO:0042393	9.33	SMARCA4 DPF2 DPF1
2	nucleosomal DNA binding	GO:0031492	9.26	SMARCD2 SMARCA4
3	lysine-acetylated histone binding	GO:0070577	8.96	SMARCA4 DPF2
4	transcription coactivator activity	GO:0003713	8.92	SS18L1 SMARCD2 SMARCA4 BICRAL

Sources

Sources for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia