MCID: SML041
MIFTS: 39

Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases
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Aliases & Classifications for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

MalaCards integrated aliases for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type:

Name: Small-Cell Carcinoma of the Ovary of Hypercalcemic Type 11 14
Small Cell Carcinoma of the Ovary, Hypercalcemic Type 5
Ovarian Small Cell Carcinoma, Hypercalcemic Type 71
Hypercalcemic Type Ovarian Small Cell Carcinoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:7651
NCIt 49 C40439
UMLS 71 C1518736

Summaries for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Disease Ontology: 11 An ovarian small cell carcinoma that is associated with paraneoplastic hypercalcemia.

MalaCards based summary: Small-Cell Carcinoma of the Ovary of Hypercalcemic Type, also known as small cell carcinoma of the ovary, hypercalcemic type, is related to small cell carcinoma and ovarian small cell carcinoma, and has symptoms including abdominal pain An important gene associated with Small-Cell Carcinoma of the Ovary of Hypercalcemic Type is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and AMPK Enzyme Complex Pathway. The drug Lysine has been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and cervix, and related phenotype is Increased Nanog expression.

Related Diseases for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Diseases related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 31.4 TP53 SMARCA4
2 ovarian small cell carcinoma 30.7 SMARCA4 SMARCA2 MSANTD2 ARID1A
3 juvenile type testicular granulosa cell tumor 30.6 SMARCA4 SMARCA2
4 atypical teratoid rhabdoid tumor 30.5 TP53 SMARCA4 SMARCA2
5 rhabdoid cancer 30.2 TP53 SMARCA4 SMARCA2 ARID1A
6 bap1 tumor predisposition syndrome 10.8
7 inherited cancer-predisposing syndrome 10.8
8 rare tumor 10.7
9 ovarian cancer 10.4
10 sarcoma 10.4
11 paine syndrome 10.3
12 endometrial cancer 10.3
13 rhabdoid tumor predisposition syndrome 1 10.3
14 rhabdoid tumor predisposition syndrome 2 10.3
15 li-fraumeni syndrome 10.3
16 small cell cancer of the lung 10.3
17 smith-magenis syndrome 10.3
18 down syndrome 10.3
19 ovarian cancer 1 10.3
20 pelvic inflammatory disease 10.3
21 serous cystadenocarcinoma 10.3
22 liposarcoma 10.3
23 uterine corpus sarcoma 10.3
24 pleomorphic liposarcoma 10.3
25 47 xxx syndrome 10.3
26 49, xxxxy syndrome 10.3
27 uterine sarcoma 10.3
28 malignant teratoma 10.2 TP53 SMARCA4
29 smarca4-deficient sarcoma of thorax 10.2 SMARCA4 SMARCA2
30 sinonasal undifferentiated carcinoma 10.2 SMARCA4 SMARCA2
31 atypical neurofibroma 10.2 TP53 SMARCA2
32 basan syndrome 10.2 SMARCA4 SMARCA2
33 adenofibroma 10.2 TP53 ARID1A
34 clear cell adenofibroma 10.2 SMARCA4 ARID1A
35 testicular granulosa cell tumor 10.1 SMARCA4 SMARCA2
36 alpha-thalassemia myelodysplasia syndrome 10.1 SMARCA4 SMARCA2
37 ovarian carcinosarcoma 10.1 TP53 ARID1A
38 ovarian clear cell adenocarcinoma 10.1 TP53 ARID1A
39 clear cell adenocarcinoma 10.1 TP53 ARID1A
40 papillary adenofibroma 10.1 SMARCA4 ARID1A
41 schimke immunoosseous dysplasia 10.1 SMARCA4 SMARCA2
42 floating-harbor syndrome 10.1 SMARCA4 SMARCA2
43 female reproductive endometrioid cancer 10.1 TP53 ARID1A
44 nasal cavity cancer 10.1 SMARCA4 SMARCA2
45 alpha thalassemia-x-linked intellectual disability syndrome 10.1 SMARCA4 SMARCA2
46 bartholin's gland adenoid cystic carcinoma 10.1 SMARCA2 ARID1A
47 developmental and epileptic encephalopathy 14 10.1 SMARCA4 SMARCA2
48 childhood medulloblastoma 10.1 TP53 SMARCA4
49 endometrial serous adenocarcinoma 10.1 TP53 ARID1A
50 large cell carcinoma with rhabdoid phenotype 10.0 TP53 SMARCA4 SMARCA2

Graphical network of the top 20 diseases related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type:



Diseases related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Symptoms & Phenotypes for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

UMLS symptoms related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type:


abdominal pain

GenomeRNAi Phenotypes related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.02 ARID1A DPF1 SMARCA4
2 Increased Nanog expression GR00371-A-3 9.02 ARID1A
3 Increased Nanog expression GR00371-A-5 9.02 ARID1A

Drugs & Therapeutics for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Drugs for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lysine Approved, Nutraceutical 56-87-1 5962

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Tazemetostat Expanded Access Program for Adults With Solid Tumors Temporarily not available NCT03874455 Tazemetostat

Search NIH Clinical Center for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Genetic Tests for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Anatomical Context for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Organs/tissues related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type:

MalaCards : Ovary, Uterus, Cervix, Breast, Heart

Publications for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Articles related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type:

(show top 50) (show all 92)
# Title Authors PMID Year
1
Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): A review and novel case with dual germline SMARCA4 and BRCA2 mutations. 62
36249907 2022
2
Small Cell Carcinoma of Ovary, Hypercalcemic Type: A Rare Case Report. 62
36243275 2022
3
The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms. 62
35331811 2022
4
In Vitro Effects of Mitochondria-Targeted Antioxidants in a Small-Cell Carcinoma of the Ovary of Hypercalcemic Type and in Type 1 and Type 2 Endometrial Cancer. 62
35453550 2022
5
Case Report of Small Cell Carcinoma of the Ovary, Hypercalcemic Type (Ovarian Rhabdoid Tumor) with SMARCB1 Mutation: A Literature Review of a Rare and Aggressive Condition. 62
35200537 2022
6
Hereditary Gynecologic Cancer Syndromes - A Narrative Review. 62
35422633 2022
7
Case Report: A Durable Response to Camrelizumab and Apatinib Combination Therapy in a Heavily Treated Small Cell Carcinoma of the Ovary, Hypercalcemic Type. 62
35903699 2022
8
Ovarian carcinoma in children with constitutional mutation of SMARCA4: single-family report and literature review. 62
33907931 2021
9
Histologic and genomic features of breast cancers with alterations affecting the SWI/SNF (SMARC) genes. 62
34079072 2021
10
Infrequent loss of SMARCA4, SMARCA2, and SMARCB1 expression in uterine mesenchymal tumors. 62
34271067 2021
11
Small Cell Carcinoma of the Ovary, Hypercalcemic Type, in a 12-Month-Old Girl. 62
34047234 2021
12
SMARCA4 (BRG1) and SMARCB1 (INI1) expression in TTF-1 negative neuroendocrine carcinomas including merkel cell carcinoma. 62
33581550 2021
13
Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines. 62
33328126 2021
14
Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases. 62
33331994 2021
15
Reprogramming of Nucleotide Metabolism Mediates Synergy between Epigenetic Therapy and MAP Kinase Inhibition. 62
33087508 2021
16
Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism. 62
33355532 2020
17
Dose-intensive regimen treatment for small-cell carcinoma of the ovary of hypercalcemic type (SCCOHT). 62
32723678 2020
18
Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): Comprehensive management of a newly diagnosed young adult. 62
32654763 2020
19
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines. 62
32156746 2020
20
Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase-Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type. 62
32409304 2020
21
Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) beyond SMARCA4 Mutations: A Comprehensive Genomic Analysis. 62
32575483 2020
22
Optimal age for genetic cancer predisposition testing in hereditary SMARCA4 Ovarian Cancer Families: How young is too young? 62
32382648 2020
23
Successful pregnancy following chemotherapy in a survivor of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): A case report and review of literature. 62
32405521 2020
24
Germline mutations of SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type and in SMARCA4-deficient undifferentiated uterine sarcoma: Clinical features of a single family and comparison of large cohorts. 62
31954538 2020
25
Loss of BRG1 (SMARCA4) Immunoexpression in a Pediatric Non-Central Nervous System Tumor Cohort. 62
31403913 2020
26
Combined CDK4/6 and PD-1 Inhibition in Refractory SMARCA4-Deficient Small-Cell Carcinoma of the Ovary, Hypercalcemic Type. 62
32704608 2020
27
Small Cell Carcinoma of Ovary, Hypercalcemic Type (Malignant Rhabdoid Tumor of Ovary) with Loss of SMARCA4 (BRG1) Expression: Report of Two Cases. 62
32149361 2020
28
The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer. 62
32649682 2020
29
Mixed Serous and Clear Cell Adenocarcinoma of the Ovary Presenting with Symptomatic Hypercalcemia: A Case Report and Clinical Considerations. 62
32069206 2020
30
[Pathological and molecular features of malignancies underlined by BAF complexes inactivation]. 62
31255411 2019
31
SMARCA4 inactivation defines a subset of undifferentiated uterine sarcomas with rhabdoid and small cell features and germline mutation association. 62
31190001 2019
32
Pembrolizumab-Induced Thyroiditis. 62
31111437 2019
33
The dilemma of early preventive oophorectomy in familial small cell carcinoma of the ovary of hypercalcemic type. 62
30886884 2019
34
SMARCA4-deficient Thoracic Sarcomas: Clinicopathologic Study of 30 Cases With an Emphasis on Their Nosology and Differential Diagnoses. 62
30451731 2019
35
The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting. 62
30858614 2019
36
Ovarian small cell carcinoma in one of a pair of monozygous twins. 62
30284660 2019
37
CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary. 62
30718512 2019
38
An In-Depth Look at Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT): Clinical Implications from Recent Molecular Findings. 62
30662543 2019
39
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): a challenge for clinicopathological diagnosis. 62
31934039 2019
40
SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications. 62
30037854 2018
41
Histone Deacetylase Inhibitors Synergize with Catalytic Inhibitors of EZH2 to Exhibit Antitumor Activity in Small Cell Carcinoma of the Ovary, Hypercalcemic Type. 62
30232145 2018
42
Multimodal molecular analysis of an atypical small cell carcinoma of the ovary, hypercalcemic type. 62
30275002 2018
43
SMARCA4-deficient undifferentiated uterine sarcoma (malignant rhabdoid tumor of the uterus): a clinicopathologic entity distinct from undifferentiated carcinoma. 62
29700418 2018
44
Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Clinical and Imaging Review. 62
28943050 2018
45
Two types of small cell carcinoma of the ovary: Two typical case reports. 62
30094313 2018
46
Immune-Active Microenvironment in Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Rationale for Immune Checkpoint Blockade. 62
29365144 2018
47
Hereditary SWI/SNF complex deficiency syndromes. 62
29397238 2018
48
Cytological features of small cell carcinoma of the ovary-hypercalcemic type/malignant ovarian rhabdoid tumor in ascitic fluid. 62
29446248 2018
49
Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition. 62
29440177 2018
50
Identification of Driver Mutations in Rare Cancers: The Role of SMARCA4 in Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT). 62
29423809 2018

Variations for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

ClinVar genetic disease variations for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TP53 NM_000546.6(TP53):c.594_611del (p.Gly199_Glu204del) DEL Likely Pathogenic
560921 rs1567551704 GRCh37: 17:7578238-7578255
GRCh38: 17:7674920-7674937
2 SMARCA4 NM_003072.5(SMARCA4):c.4533+6C>A SNV Not Provided
571659 rs1311909722 GRCh37: 19:11169045-11169045
GRCh38: 19:11058369-11058369

Cosmic variations for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type:

8 (show top 50) (show all 660)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM113486751 WT1 ovary,NS,carcinoma,small cell carcinoma c.1240A>C p.K414Q 11:32396266-32396266 12
2 COSM91385090 WT1 ovary,NS,carcinoma,small cell carcinoma c.1240A>C p.K414Q 11:32396266-32396266 12
3 COSM100783551 WT1 ovary,NS,carcinoma,small cell carcinoma c.604A>C p.K202Q 11:32396266-32396266 12
4 COSM111540839 WT1 ovary,NS,carcinoma,small cell carcinoma c.1189A>C p.K397Q 11:32396266-32396266 12
5 COSM147428189 WT1 ovary,NS,carcinoma,small cell carcinoma c.1189A>C p.K397Q 11:32396266-32396266 12
6 COSM130520647 WT1 ovary,NS,carcinoma,small cell carcinoma c.553A>C p.K185Q 11:32396266-32396266 12
7 COSM149741943 WT1 ovary,NS,carcinoma,small cell carcinoma c.1240A>C p.K414Q 11:32396266-32396266 12
8 COSM148595596 WT1 ovary,NS,carcinoma,small cell carcinoma c.1240A>C p.K414Q 11:32396266-32396266 12
9 COSM105626718 TP53 ovary,NS,carcinoma,small cell carcinoma c.761T>A p.I254N 17:7674202-7674202 12
10 COSM143944155 TP53 ovary,NS,carcinoma,small cell carcinoma c.367C>T p.R123W 17:7673776-7673776 12
11 COSM121876472 TP53 ovary,NS,carcinoma,small cell carcinoma c.448C>T p.R150W 17:7673776-7673776 12
12 COSM142841840 TP53 ovary,NS,carcinoma,small cell carcinoma c.761T>A p.I254N 17:7674202-7674202 12
13 COSM111758876 TP53 ovary,NS,carcinoma,small cell carcinoma c.844C>T p.R282W 17:7673776-7673776 12
14 COSM122739712 TP53 ovary,NS,carcinoma,small cell carcinoma c.365T>A p.I122N 17:7674202-7674202 12
15 COSM143157023 TP53 ovary,NS,carcinoma,small cell carcinoma c.367C>T p.R123W 17:7673776-7673776 12
16 COSM112259092 TP53 ovary,NS,carcinoma,small cell carcinoma c.761T>A p.I254N 17:7674202-7674202 12
17 COSM143161659 TP53 ovary,NS,carcinoma,small cell carcinoma c.284T>A p.I95N 17:7674202-7674202 12
18 COSM121883167 TP53 ovary,NS,carcinoma,small cell carcinoma c.365T>A p.I122N 17:7674202-7674202 12
19 COSM142837558 TP53 ovary,NS,carcinoma,small cell carcinoma c.844C>T p.R282W 17:7673776-7673776 12
20 COSM93189470 TP53 ovary,NS,carcinoma,small cell carcinoma c.761T>A p.I254N 17:7674202-7674202 12
21 COSM106058857 TP53 ovary,NS,carcinoma,small cell carcinoma c.761T>A p.I254N 17:7674202-7674202 12
22 COSM142565824 TP53 ovary,NS,carcinoma,small cell carcinoma c.644T>A p.I215N 17:7674202-7674202 12
23 COSM144087276 TP53 ovary,NS,carcinoma,small cell carcinoma c.367C>T p.R123W 17:7673776-7673776 12
24 COSM122277229 TP53 ovary,NS,carcinoma,small cell carcinoma c.365T>A p.I122N 17:7674202-7674202 12
25 COSM112253888 TP53 ovary,NS,carcinoma,small cell carcinoma c.844C>T p.R282W 17:7673776-7673776 12
26 COSM143371151 TP53 ovary,NS,carcinoma,small cell carcinoma c.727C>T p.R243W 17:7673776-7673776 12
27 COSM144657689 TP53 ovary,NS,carcinoma,small cell carcinoma c.644T>A p.I215N 17:7674202-7674202 12
28 COSM87905212 TP53 ovary,NS,carcinoma,small cell carcinoma c.761T>A p.I254N 17:7674202-7674202 12
29 COSM93184004 TP53 ovary,NS,carcinoma,small cell carcinoma c.844C>T p.R282W 17:7673776-7673776 12
30 COSM143948714 TP53 ovary,NS,carcinoma,small cell carcinoma c.284T>A p.I95N 17:7674202-7674202 12
31 COSM122734401 TP53 ovary,NS,carcinoma,small cell carcinoma c.448C>T p.R150W 17:7673776-7673776 12
32 COSM144651445 TP53 ovary,NS,carcinoma,small cell carcinoma c.727C>T p.R243W 17:7673776-7673776 12
33 COSM145023609 TP53 ovary,NS,carcinoma,small cell carcinoma c.644T>A p.I215N 17:7674202-7674202 12
34 COSM144019250 TP53 ovary,NS,carcinoma,small cell carcinoma c.728T>A p.I243N 17:7674202-7674202 12
35 COSM106053444 TP53 ovary,NS,carcinoma,small cell carcinoma c.844C>T p.R282W 17:7673776-7673776 12
36 COSM145017953 TP53 ovary,NS,carcinoma,small cell carcinoma c.727C>T p.R243W 17:7673776-7673776 12
37 COSM144091102 TP53 ovary,NS,carcinoma,small cell carcinoma c.284T>A p.I95N 17:7674202-7674202 12
38 COSM144310437 TP53 ovary,NS,carcinoma,small cell carcinoma c.727C>T p.R243W 17:7673776-7673776 12
39 COSM142560558 TP53 ovary,NS,carcinoma,small cell carcinoma c.727C>T p.R243W 17:7673776-7673776 12
40 COSM87898714 TP53 ovary,NS,carcinoma,small cell carcinoma c.844C>T p.R282W 17:7673776-7673776 12
41 COSM144013682 TP53 ovary,NS,carcinoma,small cell carcinoma c.811C>T p.R271W 17:7673776-7673776 12
42 COSM111764771 TP53 ovary,NS,carcinoma,small cell carcinoma c.761T>A p.I254N 17:7674202-7674202 12
43 COSM105620649 TP53 ovary,NS,carcinoma,small cell carcinoma c.782+405C>T p.? 17:7673776-7673776 12
44 COSM122271827 TP53 ovary,NS,carcinoma,small cell carcinoma c.448C>T p.R150W 17:7673776-7673776 12
45 COSM144314970 TP53 ovary,NS,carcinoma,small cell carcinoma c.644T>A p.I215N 17:7674202-7674202 12
46 COSM143376769 TP53 ovary,NS,carcinoma,small cell carcinoma c.644T>A p.I215N 17:7674202-7674202 12
47 COSM131034075 SMARCA4 ovary,NS,carcinoma,small cell carcinoma c.2362C>T p.Q788* 19:11013036-11013036 12
48 COSM148052745 SMARCA4 ovary,NS,carcinoma,small cell carcinoma c.2275-1G>T p.? 19:11012948-11012948 12
49 COSM151629014 SMARCA4 ovary,NS,carcinoma,small cell carcinoma c.3546+1G>A p.? 19:11030894-11030894 12
50 COSM151620795 SMARCA4 ovary,NS,carcinoma,small cell carcinoma c.3496C>T p.Q1166* 19:11030843-11030843 12

Expression for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Search GEO for disease gene expression data for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type.

Pathways for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Pathways related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.02 SMARCA4 SMARCA2 ARID1A
2
Show member pathways
11.8 SMARCA4 SMARCA2 ARID1A
3
Show member pathways
11.46 TP53 SMARCA4 SMARCA2
4
Show member pathways
11.34 SMARCA4 SMARCA2 ARID1A
5 11.23 TP53 SMARCA2 ARID1A
6 11.14 SMARCA4 SMARCA2
7
Show member pathways
10.98 SMARCA4 SMARCA2 DPF1 ARID1A
8 10.91 SMARCA4 SMARCA2 ARID1A
9
Show member pathways
10.66 SMARCA4 DPF1 ARID1A

GO Terms for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

Cellular components related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 10.34 TP53 SMARCA4 SMARCA2 HOXD11 DPF1 BCL7C
2 npBAF complex GO:0071564 9.88 SMARCA4 SMARCA2 ARID1A
3 bBAF complex GO:0140092 9.85 SMARCA4 SMARCA2 ARID1A
4 brahma complex GO:0035060 9.76 SMARCA2 ARID1A
5 GBAF complex GO:0140288 9.76 SMARCA4 SMARCA2 BCL7C BCL7B
6 SWI/SNF complex GO:0016514 9.65 SMARCA4 SMARCA2 BCL7C BCL7B ARID1A
7 DNA packaging complex GO:0044815 9.5 ARID1A SMARCA2 SMARCA4
8 SWI/SNF superfamily-type complex GO:0070603 9.43 SMARCA4 SMARCA2 ARID1A
9 nBAF complex GO:0071565 9.32 SS18L1 SMARCA4 SMARCA2 DPF1 ARID1A

Biological processes related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 10.41 ARID1A BCL7B BCL7C DPF1 HOXD11 SMARCA2
2 chromatin remodeling GO:0006338 10.18 ARID1A BCL7B BCL7C DPF1 SMARCA2 SMARCA4
3 regulation of G1/S transition of mitotic cell cycle GO:2000045 10.1 SMARCA4 SMARCA2 DPF1 BCL7C BCL7B ARID1A
4 positive regulation of stem cell population maintenance GO:1902459 10.07 SMARCA4 SMARCA2 BCL7C BCL7B ARID1A
5 positive regulation of cell differentiation GO:0045597 10.06 ARID1A DPF1 SMARCA2 SMARCA4
6 negative regulation of cell differentiation GO:0045596 10.03 SMARCA4 SMARCA2 BCL7C BCL7B
7 positive regulation of double-strand break repair GO:2000781 10.03 ARID1A BCL7B BCL7C DPF1 SMARCA2 SMARCA4
8 negative regulation of cell growth GO:0030308 10.02 TP53 SMARCA4 SMARCA2
9 positive regulation of myoblast differentiation GO:0045663 9.97 SMARCA4 SMARCA2 ARID1A
10 positive regulation of T cell differentiation GO:0045582 9.95 SMARCA4 SMARCA2 ARID1A
11 regulation of mitotic metaphase/anaphase transition GO:0030071 9.93 SMARCA4 SMARCA2 DPF1 BCL7C BCL7B ARID1A
12 chromatin organization GO:0006325 9.92 SS18L1 SMARCA4 SMARCA2 ARID1A
13 transcription initiation-coupled chromatin remodeling GO:0045815 9.86 TP53 ARID1A
14 nucleosome disassembly GO:0006337 9.84 SMARCA4 ARID1A
15 regulation of nucleotide-excision repair GO:2000819 9.73 ARID1A BCL7B BCL7C DPF1 SMARCA2 SMARCA4
16 regulation of G0 to G1 transition GO:0070316 9.4 SMARCA4 SMARCA2 DPF1 BCL7C BCL7B ARID1A

Molecular functions related to Small-Cell Carcinoma of the Ovary of Hypercalcemic Type according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription coactivator activity GO:0003713 9.23 SS18L1 SMARCA4 SMARCA2 ARID1A

Sources for Small-Cell Carcinoma of the Ovary of Hypercalcemic Type

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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