MCID: SML003
MIFTS: 25

Small Cell Osteogenic Sarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Small Cell Osteogenic Sarcoma

MalaCards integrated aliases for Small Cell Osteogenic Sarcoma:

Name: Small Cell Osteogenic Sarcoma 12 15
Small Cell Osteosarcoma 12 71
Round Cell Osteosarcoma 12
Osteosarcoma Small Cell 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3377
NCIt 50 C4023
SNOMED-CT 67 12302002
UMLS 71 C0279622

Summaries for Small Cell Osteogenic Sarcoma

MalaCards based summary : Small Cell Osteogenic Sarcoma, also known as small cell osteosarcoma, is related to mesenchymal chondrosarcoma and connective tissue benign neoplasm, and has symptoms including pain An important gene associated with Small Cell Osteogenic Sarcoma is ENO2 (Enolase 2). Affiliated tissues include bone and spinal cord, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Small Cell Osteogenic Sarcoma

Diseases related to Small Cell Osteogenic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 mesenchymal chondrosarcoma 30.7 SYP ENO2
2 connective tissue benign neoplasm 29.7 EWSR1 ENO2
3 ewing sarcoma 29.7 SYP EWSR1 ENO2 DUX4 CD99 CCNB3
4 sarcoma, synovial 29.6 EWSR1 DUX4 CD99 CCNB3
5 askin's tumor 29.5 SYP EWSR1 ENO2 CD99 CCNB3
6 small cell sarcoma 28.8 EWSR1 DUX4L8 DUX4L7 DUX4L1 DUX4 CCNB3
7 bone osteosarcoma 26.7 SYP SNRNP25 SATB2 MIR6859-1 EWSR1 ENO2
8 extraskeletal mesenchymal chondrosarcoma 10.3 EWSR1 CD99
9 retroperitoneal neuroblastoma 10.3 ENO2 CD99
10 ectomesenchymoma 10.3 ENO2 CD99
11 sarcomatosis 10.3 EWSR1 CREB3L1
12 ossifying fibromyxoid tumor 10.3 ENO2 CCNB3
13 bladder sarcoma 10.3 EWSR1 CD99
14 pediatric fibrosarcoma 10.3 EWSR1 CCNB3
15 chondrosarcoma 10.2
16 malignant melanocytic neoplasm of the peripheral nerve sheath 10.2 SYP ENO2
17 anal neuroendocrine tumor 10.2 SYP ENO2
18 optic nerve astrocytoma 10.2 SYP ENO2
19 cerebral neuroblastoma 10.2 SYP ENO2
20 neuronal intestinal dysplasia, type b 10.2 SYP ENO2
21 lung meningioma 10.2 SYP ENO2
22 sinonasal undifferentiated carcinoma 10.2 SYP ENO2
23 auditory system benign neoplasm 10.2 SYP ENO2
24 papillary tumor of the pineal region 10.2 SYP ENO2
25 small cell carcinoma of the bladder 10.2 SYP ENO2
26 auditory system cancer 10.2 SYP ENO2
27 cloacogenic carcinoma 10.2 SYP ENO2
28 pineal region teratoma 10.2 SYP ENO2
29 bile duct mucinous adenocarcinoma 10.2 SYP ENO2
30 ewing sarcoma of bone 10.2 EWSR1 ENO2 CD99
31 nodular prostate 10.2 SYP ENO2
32 ampulla of vater neoplasm 10.2 SYP ENO2
33 central nervous system mesenchymal non-meningothelial tumor 10.2 EWSR1 ENO2 CD99
34 appendix carcinoid tumor 10.2 SYP ENO2
35 carotid body cancer 10.2 SYP ENO2
36 gallbladder small cell carcinoma 10.2 SYP ENO2
37 ureter small cell carcinoma 10.2 SYP ENO2
38 cerebellar liponeurocytoma 10.2 SYP ENO2
39 middle ear adenoma 10.2 SYP ENO2
40 myocardium cancer 10.2 SYP CD99
41 urinary bladder small cell neuroendocrine carcinoma 10.2 SYP ENO2
42 gastric small cell carcinoma 10.2 SYP ENO2
43 jejunal neoplasm 10.2 SYP ENO2
44 frontal lobe neoplasm 10.2 SYP ENO2
45 sensory organ benign neoplasm 10.2 SYP ENO2
46 ovarian large-cell neuroendocrine carcinoma 10.2 SYP ENO2
47 gastric hemangioma 10.2 SYP ENO2
48 subependymoma 10.2 SYP ENO2
49 pineocytoma 10.2 SYP ENO2
50 pineal parenchymal tumor of intermediate differentiation 10.2 SYP ENO2

Graphical network of the top 20 diseases related to Small Cell Osteogenic Sarcoma:



Diseases related to Small Cell Osteogenic Sarcoma

Symptoms & Phenotypes for Small Cell Osteogenic Sarcoma

UMLS symptoms related to Small Cell Osteogenic Sarcoma:


pain

GenomeRNAi Phenotypes related to Small Cell Osteogenic Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-115 9.02 DUX4L7
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.02 DUX4 DUX4L7 DUX4L8
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.02 DUX4L7

Drugs & Therapeutics for Small Cell Osteogenic Sarcoma

Search Clinical Trials , NIH Clinical Center for Small Cell Osteogenic Sarcoma

Genetic Tests for Small Cell Osteogenic Sarcoma

Anatomical Context for Small Cell Osteogenic Sarcoma

MalaCards organs/tissues related to Small Cell Osteogenic Sarcoma:

40
Bone, Spinal Cord

Publications for Small Cell Osteogenic Sarcoma

Articles related to Small Cell Osteogenic Sarcoma:

(show top 50) (show all 99)
# Title Authors PMID Year
1
[Pathologic diagnosis of primary small round cell tumors of the bone]. 61 54
12920805 2003
2
NKX3.1 a useful marker for mesenchymal chondrosarcoma: An immunohistochemical study. 61
33302222 2021
3
An EWSR1-CREB3L1 Fusion Gene in Extraskeletal Undifferentiated Round Cell Sarcoma Expands the Spectrum of Genetic Landscape in the "Ewing-Like" Undifferentiated Round Cell Sarcomas. 61
32506986 2021
4
Clarifying prognostic factors of small cell osteosarcoma: A pooled analysis of 20 cases and the literature. 61
32775179 2020
5
SATB2 and TLE1 Expression in BCOR-CCNB3 (Ewing-like) Sarcoma, Mimicking Small Cell Osteosarcoma and Poorly Differentiated Synovial Sarcoma. 61
29084055 2020
6
Ewing sarcoma and Ewing-like tumors. 61
31802230 2020
7
Endobronchial metastasis as an uncommon pattern of metastatic dissemination from small cell osteosarcoma. 61
31366615 2019
8
Small round cell lesions of the bone: Diagnostic approach, differential diagnoses and impact on treatment. 61
30971540 2019
9
Laryngeal sarcomas: A case series of 5 cases. 61
30241033 2018
10
A Comparison of the Histopathologic Growth Patterns Between Non-Merkel Cell Small Round Blue Cell Tumors and Merkel Cell Carcinoma. 61
30045067 2018
11
PAX7 immunohistochemical evaluation of Ewing sarcoma and other small round cell tumours. 61
29920735 2018
12
Ewing Sarcoma and the History of Similar and Possibly Related Small Round Cell Tumors: From Whence Have We Come and Where are We Going? 61
29911999 2018
13
Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information. 61
29572501 2018
14
Osteosarcoma of the jaws in Koreans: analysis of 26 cases. 61
29142865 2017
15
Identification of the miRNA-mRNA regulatory network of small cell osteosarcoma based on RNA-seq. 61
28477009 2017
16
Small round blue cell tumors of the sinonasal tract: a differential diagnosis approach. 61
28060373 2017
17
The utility of SATB2 immunohistochemical expression in distinguishing between osteosarcomas and their malignant bone tumor mimickers, such as Ewing sarcomas and chondrosarcomas. 61
27465835 2016
18
Establishment and Characterization of a Human Small Cell Osteosarcoma Cancer Stem Cell Line: A New Possible In Vitro Model for Discovering Small Cell Osteosarcoma Biology. 61
27651797 2016
19
Small cell osteosarcoma of the parietal region: a unique case at an unusual site. 61
26628304 2015
20
Small cell osteosarcoma: clinicopathologic, immunohistochemical, and molecular analysis of 36 cases. 61
25723116 2015
21
Cytological diagnosis of small cell osteosarcoma of the bone. 61
26229255 2015
22
Utility of transmission electron microscopy in small round cell tumors. 61
25812730 2015
23
[Bone tumours in lizards and snakes. A rare clinical finding]. 61
25609210 2015
24
Round cell tumors of bone: an update on recent molecular genetic advances. 61
25105937 2014
25
Metastatic small cell osteosarcoma to the liver: a diagnostic pitfall for fine-needle aspiration cytology. 61
22865770 2014
26
Small cell extraskeletal osteosarcoma: a rare case report. 61
24711902 2014
27
Osteogenic tumors of bone. 61
24680179 2014
28
Contralateral referred pain in a patient with intramedullary spinal cord metastasis from extraskeletal small cell osteosarcoma. 61
24090113 2013
29
Small cell osteosarcoma with Ewing sarcoma breakpoint region 1 gene rearrangement detected by interphase fluorescence in situ hybridization. 61
22971270 2013
30
The role of immunohistochemistry in the analysis of the spectrum of small round cell tumours at a tertiary care centre. 61
23998069 2013
31
Galectin-1 (GAL-1) expression is a useful tool to differentiate between small cell osteosarcoma and Ewing sarcoma. 61
23681112 2013
32
[Small cell malignant tumors of bone: comparison between diagnosis using core needle biopsies and surgical specimens]. 61
23769434 2013
33
Osteosarcoma of the femur mimicking Ewing sarcoma/primitive neuroectodermal tumour on biopsy and metastatic carcinoma on resection. 61
22565380 2012
34
Small cell osteosarcoma successfully treated by high-dose ifosfamide and methotrexate, combined with carboplatin and pirarubicin. 61
22399618 2012
35
Small cell osteosarcoma of rib: diagnosis and treatment of the rare case. 61
22779940 2012
36
A novel EWSR1-CREB3L1 fusion transcript in a case of small cell osteosarcoma. 61
21987447 2011
37
Small cell osteosarcoma of the mandible: Case report and review of its diagnostic aspects. 61
22144840 2011
38
FLI-1 distinguishes Ewing sarcoma from small cell osteosarcoma and mesenchymal chondrosarcoma. 61
21084965 2011
39
Histopathological characterization of small cell osteosarcoma with immunohistochemistry and molecular genetic support. A study of 10 cases. 61
20557371 2010
40
Small cell osteosarcoma of a toe phalanx: a case report and review of literature. 61
20525255 2010
41
Small cell osteosarcoma: cytopathologic characteristics and differential diagnosis. 61
20395522 2010
42
Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and beta-catenin, Sox9, and osteocalcin immunostaining of 22 cases. 61
20138330 2010
43
Small cell tumors of bone. 61
20032633 2010
44
Small cell osteosarcoma: a case report. 61
19886558 2009
45
Malignant small round cell tumors. 61
21938141 2009
46
Small round cell tumors of bone. 61
17284103 2007
47
Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma. 61
16596382 2006
48
Femoral mesenchymal chondrosarcoma with secondary aneurysmal bone cysts mimicking a small-cell osteosarcoma. 61
16328381 2006
49
"Undifferentiated" small round cell tumors of the sinonasal tract: differential diagnosis update. 61
16468421 2005
50
Cytogenetic and spectral karyotype analyses of benign and malignant cartilage tumours. 61
15138578 2004

Variations for Small Cell Osteogenic Sarcoma

Expression for Small Cell Osteogenic Sarcoma

Search GEO for disease gene expression data for Small Cell Osteogenic Sarcoma.

Pathways for Small Cell Osteogenic Sarcoma

GO Terms for Small Cell Osteogenic Sarcoma

Biological processes related to Small Cell Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to organic substance GO:0071310 8.62 SYP SATB2

Sources for Small Cell Osteogenic Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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