MCID: SML002
MIFTS: 22

Small Cell Sarcoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Small Cell Sarcoma

MalaCards integrated aliases for Small Cell Sarcoma:

Name: Small Cell Sarcoma 12 15 17
Sarcoma, Small Cell 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3098
MeSH 44 D018228
NCIt 50 C3746
SNOMED-CT 67 73506006
UMLS 70 C0206652

Summaries for Small Cell Sarcoma

MalaCards based summary : Small Cell Sarcoma, also known as sarcoma, small cell, is related to spindle cell sarcoma and rhabdomyosarcoma 2. An important gene associated with Small Cell Sarcoma is CCNB3 (Cyclin B3). Affiliated tissues include kidney, bone and lymph node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Small Cell Sarcoma

Diseases in the Small Cell Sarcoma family:

Clear Cell Sarcoma

Diseases related to Small Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 30.0 EWSR1 CCNB3 CALD1
2 rhabdomyosarcoma 2 29.7 EWSR1 CCNB3
3 rhabdomyosarcoma 29.6 EWSR1 DUX4L1 DUX4
4 clear cell sarcoma 10.2 EWSR1 CCNB3
5 kidney rhabdoid cancer 10.2 EWSR1 CCNB3
6 askin's tumor 10.2 EWSR1 CCNB3
7 pediatric fibrosarcoma 10.2 EWSR1 CCNB3
8 sarcoma 10.1
9 endobronchial lipoma 10.1 EWSR1 CALD1
10 bladder leiomyoma 10.1 EWSR1 CALD1
11 bladder sarcoma 10.0 EWSR1 CALD1
12 sweat gland benign neoplasm 10.0 EWSR1 CALD1
13 pleomorphic liposarcoma 10.0 EWSR1 CALD1
14 connective tissue benign neoplasm 10.0 EWSR1 CALD1
15 lipomatosis, multiple 10.0 EWSR1 CALD1
16 well-differentiated liposarcoma 10.0 EWSR1 CALD1
17 skeletal muscle cancer 10.0 EWSR1 CALD1
18 muscle cancer 10.0 EWSR1 CALD1
19 myxofibrosarcoma 9.9 EWSR1 CALD1
20 mesenchymal cell neoplasm 9.9 EWSR1 CCNB3 CALD1
21 endometrial stromal tumor 9.9 EWSR1 CCNB3 CALD1
22 dedifferentiated liposarcoma 9.9 EWSR1 CALD1
23 endometrial stromal sarcoma 9.9 EWSR1 CCNB3 CALD1
24 sarcoma, synovial 9.9 EWSR1 DUX4 CCNB3
25 kidney sarcoma 9.8
26 embryonal sarcoma 9.8
27 soft tissue sarcoma 9.8
28 dysphagia 9.8
29 bone sarcoma 9.8 EWSR1 CCNB3
30 ewing sarcoma 9.8 EWSR1 DUX4 CCNB3
31 conventional central osteosarcoma 9.8 EWSR1 DUX4L8 DUX4L7 CCNB3
32 embryonal rhabdomyosarcoma 9.8 EWSR1 DUX4L1 DUX4
33 retinal telangiectasia 9.5 DUX4L8 DUX4L7 DUX4L1 DUX4
34 digenic disease 9.5 DUX4L8 DUX4L7 DUX4L1 DUX4
35 facioscapulohumeral muscular dystrophy 2 9.5 DUX4L8 DUX4L7 DUX4L1 DUX4
36 muscular dystrophy 9.5 DUX4L8 DUX4L7 DUX4L1 DUX4
37 coats disease 9.5 DUX4L8 DUX4L7 DUX4L1 DUX4
38 muscle tissue disease 9.5 DUX4L8 DUX4L7 DUX4L1 DUX4
39 muscular disease 9.5 DUX4L8 DUX4L7 DUX4L1 DUX4
40 facioscapulohumeral muscular dystrophy 1 9.5 DUX4L8 DUX4L7 DUX4L1 DUX4
41 neuromuscular disease 9.5 DUX4L8 DUX4L7 DUX4L1 DUX4
42 desmoplastic small round cell tumor 9.4 EWSR1 DUX4L8 DUX4L7 DUX4 CCNB3
43 extraosseous chondrosarcoma 9.3 EWSR1 DUX4L8 DUX4L7 DUX4L1 DUX4
44 small cell osteogenic sarcoma 9.1 EWSR1 DUX4L8 DUX4L7 DUX4L1 DUX4 CCNB3
45 kidney clear cell sarcoma 9.1 EWSR1 DUX4L8 DUX4L7 DUX4L1 DUX4 CCNB3
46 synovium cancer 9.1 EWSR1 DUX4L8 DUX4L7 DUX4L1 DUX4 CCNB3
47 chondrosarcoma, extraskeletal myxoid 9.1 EWSR1 DUX4L8 DUX4L7 DUX4L1 DUX4 CCNB3
48 bone osteosarcoma 9.1 EWSR1 DUX4L8 DUX4L7 DUX4L1 DUX4 CCNB3

Graphical network of the top 20 diseases related to Small Cell Sarcoma:



Diseases related to Small Cell Sarcoma

Symptoms & Phenotypes for Small Cell Sarcoma

GenomeRNAi Phenotypes related to Small Cell Sarcoma according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.97 DUX4L7
2 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.97 DUX4 DUX4L8
3 Increased shRNA abundance (Z-score > 2) GR00366-A-144 9.97 DUX4L7
4 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.97 DUX4 DUX4L8
5 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.97 DUX4L7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.97 DUX4 DUX4L7 DUX4L8
7 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.97 DUX4 DUX4L7 DUX4L8
8 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.97 DUX4 DUX4L8
9 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.97 DUX4 DUX4L7 DUX4L8
10 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.97 DUX4 DUX4L7 DUX4L8
11 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.97 DUX4L7
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-115 9.83 DUX4L7
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.83 DUX4 DUX4L7 DUX4L8
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.83 DUX4L7

Drugs & Therapeutics for Small Cell Sarcoma

Search Clinical Trials , NIH Clinical Center for Small Cell Sarcoma

Cochrane evidence based reviews: sarcoma, small cell

Genetic Tests for Small Cell Sarcoma

Anatomical Context for Small Cell Sarcoma

MalaCards organs/tissues related to Small Cell Sarcoma:

40
Kidney, Bone, Lymph Node, Skeletal Muscle

Publications for Small Cell Sarcoma

Articles related to Small Cell Sarcoma:

(show all 25)
# Title Authors PMID Year
1
Ewing sarcoma and Ewing-like tumors. 61
31802230 2020
2
Small round cell lesions of the bone: Diagnostic approach, differential diagnoses and impact on treatment. 61
30971540 2019
3
Fluorescent In Situ Hybridization for TP53 in the Diagnosis of Pediatric Osteogenic Sarcoma. 61
29543677 2018
4
Extraskeletal presentation of Ewing's Sarcoma. 61
29547686 2018
5
Defining the incidence and clinical significance of lymph node metastasis in soft tissue sarcoma. 61
29208319 2018
6
Oncologic outcomes in patients with nonurothelial bladder cancer. 61
29343911 2018
7
Metastatic Malignant Melanoma With Complete Loss of Differentiation Markers (Undifferentiated/Dedifferentiated Melanoma): Analysis of 14 Patients Emphasizing Phenotypic Plasticity and the Value of Molecular Testing as Surrogate Diagnostic Marker. 61
26448190 2016
8
Topotecan plus cyclophosphamide in adults with relapsed or refractory pediatric-type sarcoma: a retrospective analysis from the German Sarcoma Medical Oncology Group (AIO). 61
26163339 2015
9
Targeted polytherapy in small cell sarcoma and its association with doxorubicin. 61
24998445 2014
10
Pediatric cerebellopontine angle and internal auditory canal tumors: clinical article.. 61
23909617 2013
11
FLI-1 distinguishes Ewing sarcoma from small cell osteosarcoma and mesenchymal chondrosarcoma. 61
21084965 2011
12
Preliminary experience comparing routine cytology results with the composite results of digital image analysis and fluorescence in situ hybridization in patients undergoing EUS-guided FNA. 61
17725938 2007
13
Diagnosis and differential diagnosis of small-cell lesions of the liver. 61
9664180 1998
14
Molecular features in a biphenotypic small cell sarcoma with neuroectodermal and muscle differentiation. 61
9490279 1998
15
[Small-cell sarcoma of the esophagus as a fourth malignancy. Its palliative therapy with argon gas coagulation]. 61
9312458 1997
16
Implanted solid human tumours grow under the renal capsule of cyclosporin-immunosuppressed rats. 61
8009178 1994
17
Intrinsic and extrinsic characteristics of human tumors relevant to radiosurgery: comparative cellular radiosensitivity and hypoxic percentages. 61
7717130 1994
18
[Definition of the T parameter in nasosinusal neoplasms: a CT-MR comparison]. 61
8346361 1993
19
Nondifferentiated-type small cell sarcoma of kidney in a young woman. 61
1871901 1991
20
Steroid hormone receptors in meningiomas of Chinese patients. 61
2797392 1989
21
[Angiotensin II-induced hypertension chemotherapy of bone and soft-tissue sarcomas]. 61
2543322 1989
22
The in vitro growth, heterotransplantation, and differentiation of a human rhabdomyosarcoma cell line. 61
3777136 1986
23
Integrated imaging of hepatic tumors in childhood. Part I: Malignant lesions (primary and metastatic). 61
2981115 1985
24
Generalized urticaria to cyclophosphamide: Type I hypersensitivity to an immunosuppressive agent. 61
985658 1976
25
Rhabdomyosarcoma in childhood. 61
1153222 1975

Variations for Small Cell Sarcoma

Expression for Small Cell Sarcoma

Search GEO for disease gene expression data for Small Cell Sarcoma.

Pathways for Small Cell Sarcoma

GO Terms for Small Cell Sarcoma

Sources for Small Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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