MCID: SML002
MIFTS: 39

Small Cell Sarcoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Small Cell Sarcoma

MalaCards integrated aliases for Small Cell Sarcoma:

Name: Small Cell Sarcoma 12 15
Sarcoma, Small Cell 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3098
MeSH 44 D018228
NCIt 50 C3746
SNOMED-CT 68 73506006
UMLS 73 C0206652

Summaries for Small Cell Sarcoma

MalaCards based summary : Small Cell Sarcoma, also known as sarcoma, small cell, is related to small cell osteogenic sarcoma and monosomy 22. An important gene associated with Small Cell Sarcoma is BCOR (BCL6 Corepressor), and among its related pathways/superpathways are Human cytomegalovirus infection and PI3K-Akt signaling pathway. Affiliated tissues include skin, kidney and brain, and related phenotypes are Increased proliferation and immune system

Related Diseases for Small Cell Sarcoma

Diseases in the Small Cell Sarcoma family:

Clear Cell Sarcoma

Diseases related to Small Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 small cell osteogenic sarcoma 11.2
2 monosomy 22 10.2 NF2 SMARCB1
3 rhabdoid meningioma 10.2 NF2 SMARCB1
4 schwannomatosis 1 10.2 NF2 SMARCB1
5 malignant conjunctival melanoma 10.2 NRAS SOX10
6 splenic diffuse red pulp small b-cell lymphoma 10.2 BCOR TP53
7 conventional central osteosarcoma 10.2 BCOR MDM2
8 malignant spindle cell melanoma 10.2 NRAS SOX10
9 atypical neurofibroma 10.2 NF2 SOX10
10 cerebral convexity meningioma 10.2 NF2 TP53
11 olfactory groove meningioma 10.2 NF2 TP53
12 zika virus infection 10.2 MDM2 TP53
13 actinic cheilitis 10.2 MDM2 TP53
14 spinal cancer 10.2 NF2 TP53
15 cerebral ventricle cancer 10.2 SMARCB1 TP53
16 neurilemmoma 10.2 NF2 SMARCB1 SOX10
17 chordoid glioma 10.1 NF2 TP53
18 retroperitoneal sarcoma 10.1 BCOR MDM2 SMARCB1
19 undifferentiated embryonal sarcoma of the liver 10.1 CDK4 MDM2
20 sclerosing liposarcoma 10.1 MDM2 TP53
21 cornea cancer 10.1 CDK4 NF2
22 lip cancer 10.1 MDM2 TP53
23 spindle cell lipoma 10.1 CDK4 MDM2
24 cellular myxoid liposarcoma 10.1 CDK4 MDM2
25 rhabdoid cancer 10.1 BCOR SMARCB1 TP53
26 malignant ependymoma 10.1 NF2 TP53
27 breast angiosarcoma 10.1 MLANA SOX10
28 lipoblastoma 10.1 CDK4 MDM2
29 anterior cranial fossa meningioma 10.1 NF2 TP53
30 mixed liposarcoma 10.1 CDK4 MDM2
31 nervous system benign neoplasm 10.1 NF2 SMARCB1 TP53
32 anaplastic ependymoma 10.1 MDM2 NF2
33 periosteal chondrosarcoma 10.1 CDK4 MDM2
34 central nervous system cancer 10.1 NF2 SMARCB1 TP53
35 chondroid lipoma 10.1 CDK4 MDM2
36 cerebral neuroblastoma 10.1 ANXA5 TP53
37 meningioma, familial 10.1 NF2 SMARCB1 TP53
38 bone osteosarcoma 10.1 BCOR CDK4 MDM2
39 peripheral nervous system neoplasm 10.1 NF2 NRAS TP53
40 meningeal melanomatosis 10.1 NRAS TP53
41 atypical lipomatous tumor 10.1 CDK4 MDM2 SMARCB1
42 synovium cancer 10.1 CCNB3 SMARCB1
43 ischemic fasciitis 10.0 CDK4 MDM2
44 skin melanoma 10.0 MDM2 NRAS TP53
45 juxtacortical osteosarcoma 10.0 CDK4 HSP90AA1 MDM2
46 liver angiosarcoma 10.0 CDK4 NRAS TP53
47 human immunodeficiency virus type 1 10.0 CR2 HSP90AA1 SMARCB1 TAT
48 liposarcoma 10.0 CDK4 MDM2 TP53
49 ring chromosome 7 10.0 CDK4 MDM2 TP53
50 periosteal osteogenic sarcoma 10.0 CDK4 MDM2 TP53

Graphical network of the top 20 diseases related to Small Cell Sarcoma:



Diseases related to Small Cell Sarcoma

Symptoms & Phenotypes for Small Cell Sarcoma

GenomeRNAi Phenotypes related to Small Cell Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.8 NF2 SMARCB1 TP53

MGI Mouse Phenotypes related to Small Cell Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.1 ANXA5 BCOR CDK4 CR2 HSP90AA1 MDM2
2 embryo MP:0005380 10.03 BCOR CDK4 MDM2 NF2 NRAS SMARCB1
3 digestive/alimentary MP:0005381 9.93 CDK4 MDM2 NRAS SMARCB1 SOX10 TP53
4 integument MP:0010771 9.91 CDK4 MDM2 MLANA NF2 NRAS SOX10
5 mortality/aging MP:0010768 9.85 BCOR CDK4 CR2 HSP90AA1 MDM2 NF2
6 limbs/digits/tail MP:0005371 9.8 ANXA5 HSP90AA1 MDM2 NRAS SOX10 TP53
7 liver/biliary system MP:0005370 9.73 CDK4 MDM2 NF2 NRAS SMARCB1 TP53
8 neoplasm MP:0002006 9.5 CDK4 MDM2 NF2 NRAS SMARCB1 SOX10
9 pigmentation MP:0001186 9.1 CDK4 MDM2 MLANA NRAS SOX10 TP53

Drugs & Therapeutics for Small Cell Sarcoma

Search Clinical Trials , NIH Clinical Center for Small Cell Sarcoma

Cochrane evidence based reviews: sarcoma, small cell

Genetic Tests for Small Cell Sarcoma

Anatomical Context for Small Cell Sarcoma

MalaCards organs/tissues related to Small Cell Sarcoma:

41
Skin, Kidney, Brain, Liver, Bone, Spinal Cord, T Cells

Publications for Small Cell Sarcoma

Articles related to Small Cell Sarcoma:

# Title Authors Year
1
Targeted polytherapy in small cell sarcoma and its association with doxorubicin. ( 24998445 )
2014
2
Molecular features in a biphenotypic small cell sarcoma with neuroectodermal and muscle differentiation. ( 9490279 )
1998
3
Nondifferentiated-type small cell sarcoma of kidney in a young woman. ( 1871901 )
1991

Variations for Small Cell Sarcoma

Expression for Small Cell Sarcoma

Search GEO for disease gene expression data for Small Cell Sarcoma.

Pathways for Small Cell Sarcoma

Pathways related to Small Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 CCNB3 CDK4 MDM2 NRAS TP53
2
Show member pathways
12.84 CDK4 HSP90AA1 MDM2 NRAS TP53
3
Show member pathways
12.69 CDK4 HSP90AA1 MDM2 NRAS TP53
4 12.66 CDK4 HSP90AA1 MDM2 NRAS TP53
5
Show member pathways
12.38 HSP90AA1 MDM2 NRAS TP53
6
Show member pathways
12.19 CCNB3 CDK4 MDM2 TP53
7 12.17 CCNB3 CDK4 MDM2 TP53
8 12.1 CDK4 CR2 MDM2 TP53
9 12.08 CDK4 MDM2 NRAS TP53
10 12.01 CDK4 MDM2 TP53
11
Show member pathways
11.95 CCNB3 MDM2 NRAS
12
Show member pathways
11.9 CDK4 HSP90AA1 MDM2 NRAS TP53
13 11.86 MDM2 NRAS TP53
14 11.85 MDM2 NRAS TP53
15 11.71 CDK4 HSP90AA1 MDM2 NRAS TP53
16 11.7 CDK4 MDM2 TP53
17
Show member pathways
11.69 CCNB3 MDM2 TP53
18 11.66 HSP90AA1 MDM2 TP53
19 11.64 CDK4 HSP90AA1 TP53
20 11.56 CCNB3 CDK4 MDM2 NRAS TP53
21 11.42 CDK4 MDM2 NRAS TP53
22 11.37 HSP90AA1 MDM2 TP53
23 11.27 CDK4 MDM2 TP53
24 11.22 CDK4 MDM2 TP53
25 11.07 CDK4 MDM2 NF2 NRAS TP53
26 11.05 CDK4 MDM2 TP53
27 10.98 MDM2 TP53
28
Show member pathways
10.98 MDM2 TP53
29 10.91 CCNB3 TP53
30 10.78 HSP90AA1 TP53

GO Terms for Small Cell Sarcoma

Cellular components related to Small Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.02 CDK4 HSP90AA1 MDM2 SMARCB1 TP53

Biological processes related to Small Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell cycle GO:0045787 9.33 CCNB3 CDK4 MDM2
2 negative regulation of cell cycle arrest GO:0071157 9.32 CDK4 MDM2
3 positive regulation of protein export from nucleus GO:0046827 9.26 MDM2 TP53
4 cellular response to actinomycin D GO:0072717 8.96 MDM2 TP53
5 response to antibiotic GO:0046677 8.8 HSP90AA1 MDM2 TP53

Molecular functions related to Small Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone deacetylase binding GO:0042826 9.5 BCOR HSP90AA1 TP53
2 protein binding GO:0005515 9.5 ANXA5 BCOR CALD1 CCNB3 CDK4 CR2
3 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.43 SMARCB1 SOX10 TP53
4 p53 binding GO:0002039 9.33 MDM2 SMARCB1 TP53
5 disordered domain specific binding GO:0097718 9.13 HSP90AA1 MDM2 TP53

Sources for Small Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....