MCID: SML002
MIFTS: 35

Small Cell Sarcoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Small Cell Sarcoma

MalaCards integrated aliases for Small Cell Sarcoma:

Name: Small Cell Sarcoma 12 15 17
Sarcoma, Small Cell 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3098
MeSH 45 D018228
NCIt 51 C3746
SNOMED-CT 69 73506006
UMLS 74 C0206652

Summaries for Small Cell Sarcoma

MalaCards based summary : Small Cell Sarcoma, also known as sarcoma, small cell, is related to ewing sarcoma and small cell osteogenic sarcoma. An important gene associated with Small Cell Sarcoma is BCOR (BCL6 Corepressor), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Human cytomegalovirus infection. Affiliated tissues include bone, kidney and skin, and related phenotypes are Increased proliferation and behavior/neurological

Related Diseases for Small Cell Sarcoma

Diseases in the Small Cell Sarcoma family:

Clear Cell Sarcoma

Diseases related to Small Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma 28.2 ANXA5 BCOR CCNB3 CDK4 MDM2 PAX3
2 small cell osteogenic sarcoma 11.6
3 monosomy 22 10.4 NF2 SMARCB1
4 rhabdoid meningioma 10.4 NF2 SMARCB1
5 schwannomatosis 1 10.4 NF2 SMARCB1
6 splenic diffuse red pulp small b-cell lymphoma 10.4 BCOR TP53
7 malignant conjunctival melanoma 10.4 NRAS SOX10
8 cerebral convexity meningioma 10.3 NF2 TP53
9 malignant spindle cell melanoma 10.3 NRAS SOX10
10 conventional central osteosarcoma 10.3 BCOR MDM2
11 olfactory groove meningioma 10.3 NF2 TP53
12 spinal cancer 10.3 NF2 TP53
13 zika virus infection 10.3 MDM2 TP53
14 atypical neurofibroma 10.3 NF2 SOX10
15 actinic cheilitis 10.3 MDM2 TP53
16 cornea cancer 10.3 CDK4 NF2
17 cerebral ventricle cancer 10.3 SMARCB1 TP53
18 chordoid glioma 10.3 NF2 TP53
19 neurilemmoma 10.3 NF2 SMARCB1 SOX10
20 sclerosing liposarcoma 10.3 MDM2 TP53
21 lip cancer 10.3 MDM2 TP53
22 rhabdoid cancer 10.2 BCOR SMARCB1 TP53
23 undifferentiated embryonal sarcoma of the liver 10.2 CDK4 MDM2
24 spindle cell lipoma 10.2 CDK4 MDM2
25 retroperitoneal sarcoma 10.2 BCOR MDM2 SMARCB1
26 cellular myxoid liposarcoma 10.2 CDK4 MDM2
27 sapho syndrome 10.2 MDM2 TP53
28 lipoblastoma 10.2 CDK4 MDM2
29 cerebral neuroblastoma 10.2 ANXA5 TP53
30 waardenburg syndrome, type 3 10.2 PAX3 SOX10
31 central nervous system cancer 10.2 NF2 SMARCB1 TP53
32 waardenburg syndrome, type 4b 10.2 PAX3 SOX10
33 malignant ependymoma 10.2 NF2 TP53
34 peripheral nervous system neoplasm 10.2 NF2 NRAS TP53
35 meningioma, familial 10.2 NF2 SMARCB1 TP53
36 mixed liposarcoma 10.2 CDK4 MDM2
37 breast angiosarcoma 10.2 MLANA SOX10
38 anterior cranial fossa meningioma 10.2 NF2 TP53
39 bone osteosarcoma 10.1 BCOR CDK4 MDM2
40 periosteal chondrosarcoma 10.1 CDK4 MDM2
41 tietz albinism-deafness syndrome 10.1 PAX3 SOX10
42 chondroid lipoma 10.1 CDK4 MDM2
43 atypical lipomatous tumor 10.1 CDK4 MDM2 SMARCB1
44 skin melanoma 10.1 MDM2 NRAS TP53
45 liver angiosarcoma 10.1 CDK4 NRAS TP53
46 liposarcoma 10.1 CDK4 MDM2 TP53
47 ring chromosome 7 10.1 CDK4 MDM2 TP53
48 juxtacortical osteosarcoma 10.1 CDK4 HSP90AA1 MDM2
49 periosteal osteogenic sarcoma 10.1 CDK4 MDM2 TP53
50 dedifferentiated liposarcoma 10.1 CDK4 MDM2 TP53

Graphical network of the top 20 diseases related to Small Cell Sarcoma:



Diseases related to Small Cell Sarcoma

Symptoms & Phenotypes for Small Cell Sarcoma

GenomeRNAi Phenotypes related to Small Cell Sarcoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.8 NF2 SMARCB1 TP53

MGI Mouse Phenotypes related to Small Cell Sarcoma:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.21 CDK4 HSP90AA1 MDM2 NF2 NRAS PAX3
2 cellular MP:0005384 10.2 BCOR CDK4 HSP90AA1 MDM2 NRAS PAX3
3 growth/size/body region MP:0005378 10.18 BCOR CDK4 HSP90AA1 MDM2 NF2 NRAS
4 embryo MP:0005380 10.16 BCOR CDK4 MDM2 NF2 NRAS PAX3
5 immune system MP:0005387 10.16 ANXA5 BCOR CDK4 HSP90AA1 MDM2 NF2
6 endocrine/exocrine gland MP:0005379 10.1 CDK4 HSP90AA1 MDM2 NF2 NRAS PAX3
7 digestive/alimentary MP:0005381 10.07 CDK4 MDM2 NRAS PAX3 SMARCB1 SOX10
8 integument MP:0010771 10.03 CDK4 MDM2 MLANA NF2 NRAS PAX3
9 mortality/aging MP:0010768 10.02 BCOR CDK4 HSP90AA1 MDM2 NF2 NRAS
10 craniofacial MP:0005382 10.01 HSP90AA1 MDM2 NF2 NRAS PAX3 TP53
11 liver/biliary system MP:0005370 9.91 CDK4 MDM2 NF2 NRAS PAX3 SMARCB1
12 limbs/digits/tail MP:0005371 9.88 ANXA5 MDM2 NRAS PAX3 SOX10 TP53
13 neoplasm MP:0002006 9.86 CDK4 MDM2 NF2 NRAS PAX3 SMARCB1
14 no phenotypic analysis MP:0003012 9.63 MDM2 MLANA NRAS PAX3 SOX10 TP53
15 normal MP:0002873 9.5 ANXA5 CDK4 MDM2 NRAS PAX3 SOX10
16 pigmentation MP:0001186 9.17 CDK4 MDM2 MLANA NRAS PAX3 SOX10

Drugs & Therapeutics for Small Cell Sarcoma

Search Clinical Trials , NIH Clinical Center for Small Cell Sarcoma

Cochrane evidence based reviews: sarcoma, small cell

Genetic Tests for Small Cell Sarcoma

Anatomical Context for Small Cell Sarcoma

MalaCards organs/tissues related to Small Cell Sarcoma:

42
Bone, Kidney, Skin, Liver, B Cells, Brain, Myeloid

Publications for Small Cell Sarcoma

Articles related to Small Cell Sarcoma:

# Title Authors Year
1
Targeted polytherapy in small cell sarcoma and its association with doxorubicin. ( 24998445 )
2014
2
Molecular features in a biphenotypic small cell sarcoma with neuroectodermal and muscle differentiation. ( 9490279 )
1998
3
Nondifferentiated-type small cell sarcoma of kidney in a young woman. ( 1871901 )
1991

Variations for Small Cell Sarcoma

Expression for Small Cell Sarcoma

Search GEO for disease gene expression data for Small Cell Sarcoma.

Pathways for Small Cell Sarcoma

Pathways related to Small Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 CDK4 HSP90AA1 MDM2 NRAS TP53
2
Show member pathways
12.82 CCNB3 CDK4 MDM2 NRAS TP53
3
Show member pathways
12.69 CDK4 HSP90AA1 MDM2 NRAS TP53
4 12.66 CDK4 HSP90AA1 MDM2 NRAS TP53
5
Show member pathways
12.38 HSP90AA1 MDM2 NRAS TP53
6
Show member pathways
12.19 CCNB3 CDK4 MDM2 TP53
7 12.17 CCNB3 CDK4 MDM2 TP53
8 12.1 CDK4 MDM2 NRAS TP53
9 12.01 CDK4 MDM2 TP53
10 11.97 BCOR NF2 PAX3
11
Show member pathways
11.95 CCNB3 MDM2 NRAS
12
Show member pathways
11.9 CDK4 HSP90AA1 MDM2 NRAS TP53
13 11.86 MDM2 NRAS TP53
14 11.85 MDM2 NRAS TP53
15 11.71 CDK4 HSP90AA1 MDM2 NRAS TP53
16 11.7 CDK4 MDM2 TP53
17
Show member pathways
11.69 CCNB3 MDM2 TP53
18 11.66 HSP90AA1 MDM2 TP53
19 11.64 CDK4 HSP90AA1 TP53
20 11.56 CCNB3 CDK4 MDM2 NRAS TP53
21 11.42 CDK4 MDM2 NRAS TP53
22 11.4 MDM2 PAX3 SMARCB1
23 11.37 HSP90AA1 MDM2 TP53
24 11.27 CDK4 MDM2 TP53
25 11.22 CDK4 MDM2 TP53
26 11.07 CDK4 MDM2 NF2 NRAS TP53
27 11.05 CDK4 MDM2 TP53
28 10.99 MDM2 TP53
29
Show member pathways
10.98 MDM2 TP53
30 10.91 CCNB3 TP53
31 10.78 HSP90AA1 TP53

GO Terms for Small Cell Sarcoma

Cellular components related to Small Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.02 CDK4 HSP90AA1 MDM2 SMARCB1 TP53

Biological processes related to Small Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell cycle GO:0045787 9.33 CCNB3 CDK4 MDM2
2 negative regulation of cell cycle arrest GO:0071157 9.32 CDK4 MDM2
3 positive regulation of protein export from nucleus GO:0046827 9.26 MDM2 TP53
4 cellular response to actinomycin D GO:0072717 8.96 MDM2 TP53
5 response to antibiotic GO:0046677 8.8 HSP90AA1 MDM2 TP53

Molecular functions related to Small Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone deacetylase binding GO:0042826 9.5 BCOR HSP90AA1 TP53
2 protein binding GO:0005515 9.5 ANXA5 BCOR CALD1 CCNB3 CDK4 HSP90AA1
3 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.43 SMARCB1 SOX10 TP53
4 p53 binding GO:0002039 9.33 MDM2 SMARCB1 TP53
5 disordered domain specific binding GO:0097718 9.13 HSP90AA1 MDM2 TP53

Sources for Small Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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