MCID: SML015
MIFTS: 34

Small Intestinal Sarcoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Small Intestinal Sarcoma

MalaCards integrated aliases for Small Intestinal Sarcoma:

Name: Small Intestinal Sarcoma 12 15 73
Sarcoma of the Small Intestine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5272
NCIt 50 C5335
UMLS 73 C1336007

Summaries for Small Intestinal Sarcoma

Disease Ontology : 12 A sarcoma and malignant tumor of small intestine that is located in the small intestine.

MalaCards based summary : Small Intestinal Sarcoma, also known as sarcoma of the small intestine, is related to small intestine leiomyosarcoma and clear cell sarcoma. An important gene associated with Small Intestinal Sarcoma is IHH (Indian Hedgehog), and among its related pathways/superpathways are Innate Lymphoid Cell Differentiation Pathways and C-MYB transcription factor network. Affiliated tissues include small intestine, bone and myeloid, and related phenotypes are Decreased human papilloma virus 16 (HPV16) pseudovirus infection and cardiovascular system

Related Diseases for Small Intestinal Sarcoma

Diseases related to Small Intestinal Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 small intestine leiomyosarcoma 30.2 KIT IHH IGF2 GCG CD34 ANO1
2 clear cell sarcoma 29.8 IGF2 KIT
3 leiomyoma 29.5 CD34 IGF2 KIT
4 small bowel fibrosarcoma 11.1
5 myeloid sarcoma 10.4
6 leiomyosarcoma 10.1 IGF2 KIT
7 embryoma 10.1 IGF2 KIT
8 malignant anus melanoma 10.1 ADAM17 KIT
9 leukemia 10.1
10 congenital mesoblastic nephroma 10.1 IGF2 KIT
11 sarcoma 10.0
12 gastric cardia carcinoma 10.0 ANO1 KIT
13 reticulum cell sarcoma 10.0
14 ovarian brenner tumor 10.0 ANO1 KIT
15 gallbladder leiomyoma 10.0 CD34 KIT
16 lung leiomyosarcoma 10.0 CD34 KIT
17 deep leiomyoma 10.0 CD34 KIT
18 extracutaneous mastocytoma 10.0 CD34 KIT
19 gallbladder sarcoma 10.0 CD34 KIT
20 prostate leiomyosarcoma 10.0 CD34 KIT
21 plexiform schwannoma 10.0 CD34 KIT
22 conventional fibrosarcoma 10.0 CD34 KIT
23 peritoneal benign neoplasm 10.0 CD34 KIT
24 diffuse peritoneal leiomyomatosis 10.0 CD34 KIT
25 breast angiosarcoma 10.0 CD34 KIT
26 senile angioma 10.0 CD34 KIT
27 angiomyoma 10.0 CD34 KIT
28 spindle cell liposarcoma 10.0 CD34 KIT
29 pancreas disease 10.0 GCG IGF2
30 mesenchymal cell neoplasm 9.9 CD34 KIT
31 cardiovascular organ benign neoplasm 9.9 CD34 KIT
32 periosteal osteogenic sarcoma 9.9 CD34 IGF2
33 benign perivascular tumor 9.9 CD34 KIT
34 nervous system benign neoplasm 9.9 CD34 KIT
35 vascular cancer 9.9 CD34 KIT
36 connective tissue cancer 9.9 CD34 KIT
37 gastrointestinal system disease 9.9 ADAM17 GCG KIT
38 gastric leiomyosarcoma 9.9 KIT IGF2 ANO1
39 neurofibroma 9.9 CD34 KIT
40 endocrine gland cancer 9.9 ADAM17 GCG IGF2
41 germ cell cancer 9.9 IGF2 KIT
42 leiomyoma, uterine 9.8
43 sarcoma, synovial 9.8
44 ewing sarcoma 9.8
45 chronic myelomonocytic leukemia 9.8
46 mast-cell sarcoma 9.8
47 extraosseous ewing's sarcoma 9.8
48 monophasic synovial sarcoma 9.8
49 follicular dendritic cell sarcoma 9.8
50 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.8

Graphical network of the top 20 diseases related to Small Intestinal Sarcoma:



Diseases related to Small Intestinal Sarcoma

Symptoms & Phenotypes for Small Intestinal Sarcoma

GenomeRNAi Phenotypes related to Small Intestinal Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human papilloma virus 16 (HPV16) pseudovirus infection GR00306-A 8.92 GCG IGF2 IHH KIT

MGI Mouse Phenotypes related to Small Intestinal Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 ADAM17 ANO1 IGF2 IHH KIT
2 digestive/alimentary MP:0005381 9.77 ADAM17 ANO1 IGF2 IHH KIT
3 integument MP:0010771 9.72 ADAM17 ANO1 CD34 IGF2 KIT
4 limbs/digits/tail MP:0005371 9.56 ADAM17 IGF2 IHH KIT
5 muscle MP:0005369 9.55 ADAM17 ANO1 IGF2 IHH KIT
6 respiratory system MP:0005388 9.35 ADAM17 ANO1 IGF2 IHH KIT
7 skeleton MP:0005390 9.02 ADAM17 ANO1 IGF2 IHH KIT

Drugs & Therapeutics for Small Intestinal Sarcoma

Search Clinical Trials , NIH Clinical Center for Small Intestinal Sarcoma

Genetic Tests for Small Intestinal Sarcoma

Anatomical Context for Small Intestinal Sarcoma

MalaCards organs/tissues related to Small Intestinal Sarcoma:

41
Small Intestine, Bone, Myeloid, Bone Marrow, Lung, Liver, Pancreas

The Foundational Model of Anatomy Ontology organs/tissues related to Small Intestinal Sarcoma:

19
The Small Intestine

Publications for Small Intestinal Sarcoma

Articles related to Small Intestinal Sarcoma:

(show all 36)
# Title Authors Year
1
Myeloid sarcoma of the small intestine in a patient without overt acute myeloid leukaemia: a challenging diagnosis of a rare condition. ( 29848520 )
2018
2
Follicular dendritic cell sarcoma of the small intestine detected by double-balloon enteroscopy. ( 28543909 )
2017
3
Primary Myeloid Sarcoma of the Small Intestine: Case Report and Literature Review. ( 27509642 )
2016
4
Granulocytic sarcoma of the small intestine in a patient with chronic myelomonocytic leukemia. ( 25251682 )
2014
5
The utility of balloon enteroscopy in the diagnosis of histiocytic sarcoma of the small intestine: a case report. ( 23464970 )
2013
6
A rare case of ewing's sarcoma of the small intestine. ( 23336641 )
2013
7
Ewing's sarcoma of the small intestine misdiagnosed as a voluminous pedunculated uterine leiomyoma. ( 22410473 )
2012
8
Mast cell sarcoma of the small intestine: a case report. ( 21778298 )
2011
9
Donor cell leukemia following unrelated donor bone marrow transplantation for primary granulocytic sarcoma of the small intestine. ( 21328426 )
2011
10
Low-grade fibromyxoid sarcoma of the small intestine: report of 4 cases with molecular cytogenetic confirmation. ( 21677541 )
2011
11
Management of monophasic synovial sarcoma of the small intestine. ( 21333201 )
2010
12
Granulocytic sarcoma of the small intestine: an unusual presentation of acute myelogenous leukaemia. ( 20209703 )
2010
13
Clear-cell sarcoma of the small intestine detected by FDG-PET/CT during comprehensive examination of an inflammatory reaction. ( 19262017 )
2009
14
Isolated granulocytic sarcoma of the small intestine successfully treated with chemotherapy and bone marrow transplantation. ( 18365139 )
2008
15
Primitive neurectodermal tumors: a case of extraosseous Ewing's sarcoma of the small intestine and review of the literature. ( 17309187 )
2006
16
Granulocytic sarcoma of the small intestine. ( 17090205 )
2006
17
Granulocytic sarcoma of the small intestine in a child without leukemia: report of a case with cytologic findings and immunophenotyping pitfalls. ( 15471256 )
2004
18
Granulocytic sarcoma of the small intestine with CBFbeta/MYH11 fusion gene: report of an aleukaemic case and review of the literature. ( 12859999 )
2003
19
Ewing sarcoma of the small intestine. ( 11878783 )
2001
20
Granulocytic sarcoma of the small intestine preceding acute myelomonocytic leukemia with abnormal eosinophils and inv(16). ( 3180024 )
1988
21
Granulocytic sarcoma of the small intestine: a case report. ( 3194190 )
1988
22
Multiple immunoblastic sarcoma of the small intestine following renal transplantation. ( 7020183 )
1981
23
Sarcoma of the small intestine. ( 5535906 )
1970
24
A case of Kaposi's Sarcoma of the small intestine. ( 6078917 )
1967
25
RETICULUM CELL SARCOMA OF THE SMALL INTESTINE DIAGNOSED BY PERORAL INTESTINAL BIOPSY. REPORT OF A CASE. ( 14043540 )
1963
26
Reticulum cell sarcoma of the small intestine in childhood. A review and case report. ( 13846808 )
1960
27
Sarcoma of the small intestine. ( 14408711 )
1959
28
Lymphoblastic sarcoma of the small intestine with primary manifestations in the skin. ( 18876750 )
1948
29
Large-round-cell sarcoma of the small intestine. ( 21025559 )
1946
30
SARCOMA OF THE SMALL INTESTINE: REPORT OF FOUR CASES. ( 17857997 )
1942
31
SARCOMA OF THE SMALL INTESTINE. ( 20774353 )
1928
32
Two Cases of Sarcoma of the Small Intestine. ( 19983463 )
1923
33
IX. Sarcoma of the Small Intestine. ( 17863189 )
1914
34
SARCOMA OF THE SMALL INTESTINE. ( 17862817 )
1912
35
SARCOMA OF THE SMALL INTESTINE AND MESENTERY: REPORT OF A CASE IN WHICH SIX FEET AND FIVE INCHES OF THE SMALL INTESTINE WERE REMOVED, WITH RECOVERY. ( 17861928 )
1907
36
A Case of Lympho-Sarcoma of the Small Intestine. ( 29003025 )
1903

Variations for Small Intestinal Sarcoma

Expression for Small Intestinal Sarcoma

Search GEO for disease gene expression data for Small Intestinal Sarcoma.

Pathways for Small Intestinal Sarcoma

Pathways related to Small Intestinal Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.27 CD34 KIT
2 11.21 CD34 KIT
3 11.13 CD34 KIT
4 10.97 IGF2 IHH
5 10.68 CD34 KIT
6 10.35 IGF2 KIT

GO Terms for Small Intestinal Sarcoma

Cellular components related to Small Intestinal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 ADAM17 ANO1 CD34

Biological processes related to Small Intestinal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.32 IGF2 IHH
2 hemopoiesis GO:0030097 9.26 CD34 KIT
3 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.16 ANO1 GCG
4 cell motility GO:0048870 8.96 ADAM17 CD34
5 positive regulation of cell proliferation GO:0008284 8.92 ADAM17 IGF2 IHH KIT

Sources for Small Intestinal Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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