MCID: SML015
MIFTS: 33

Small Intestinal Sarcoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Small Intestinal Sarcoma

MalaCards integrated aliases for Small Intestinal Sarcoma:

Name: Small Intestinal Sarcoma 12 15 70
Sarcoma of the Small Intestine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5272
NCIt 50 C5335
UMLS 70 C1336007

Summaries for Small Intestinal Sarcoma

Disease Ontology : 12 A sarcoma and malignant tumor of small intestine that is located in the small intestine.

MalaCards based summary : Small Intestinal Sarcoma, also known as sarcoma of the small intestine, is related to sarcoma and myeloid sarcoma. An important gene associated with Small Intestinal Sarcoma is ANO1 (Anoctamin 1), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include small intestine, myeloid and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Small Intestinal Sarcoma

Diseases related to Small Intestinal Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 sarcoma 30.8 WT1 PDGFRA KIT EWSR1
2 myeloid sarcoma 30.3 PTPRC KIT CD68
3 rare tumor 30.2 KIT EWSR1
4 clear cell sarcoma 29.7 WT1 KIT EWSR1
5 sarcoma, synovial 29.6 WT1 KIT EWSR1
6 follicular dendritic cell sarcoma 29.6 KIT CD68
7 myeloproliferative neoplasm 29.5 WT1 PDGFRA KIT
8 leukemia, acute myeloid 29.0 WT1 PTPRC PDGFRA NTRK1 KIT
9 ewing sarcoma 28.9 WT1 PTPRC PDGFRA KIT EWSR1
10 small bowel fibrosarcoma 11.1
11 spindle cell sarcoma 11.0
12 reticulum cell sarcoma 10.4
13 cauda equina neoplasm 10.2 WT1 EWSR1
14 sarcomatosis 10.2 WT1 EWSR1
15 kaposi sarcoma 10.2
16 peritonitis 10.2
17 histiocytic sarcoma 10.2
18 benign peritoneal mesothelioma 10.2 WT1 ANO1
19 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.2 PTPRC EWSR1
20 prostate neuroendocrine neoplasm 10.1 PTPRC KLK3
21 pulmonary artery leiomyosarcoma 10.1 CD68 ANO1
22 olfactory nerve neoplasm 10.1 PTPRC EWSR1
23 cranial nerve malignant neoplasm 10.1 PTPRC EWSR1
24 microinvasive cervical squamous cell carcinoma 10.1 WT1 PTPRC
25 intravascular fasciitis 10.1 CD68 ANO1
26 cranial nerve neoplasm 10.1 PTPRC EWSR1
27 angiokeratoma circumscriptum 10.1 WT1 NTRK1
28 pediatric fibrosarcoma 10.1 NTRK1 EWSR1
29 congenital fibrosarcoma 10.1 NTRK1 EWSR1
30 epididymal neoplasm 10.1 WT1 CD68
31 benign struma ovarii 10.0 WT1 NTRK1
32 sweat gland disease 10.0 NTRK1 EWSR1
33 epithelioid cell synovial sarcoma 10.0 WT1 EWSR1 ANO1
34 leiomyoma, uterine 10.0
35 celiac disease 1 10.0
36 graft-versus-host disease 10.0
37 chronic myelomonocytic leukemia 10.0
38 epithelioid inflammatory myofibroblastic sarcoma 10.0
39 leukemia 10.0
40 acute leukemia 10.0
41 leiomyoma 10.0
42 melanoma 10.0
43 mast-cell sarcoma 10.0
44 monophasic synovial sarcoma 10.0
45 appendicitis 10.0
46 myeloid leukemia 10.0
47 hypereosinophilic syndrome 10.0
48 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.0
49 soft tissue sarcoma 10.0
50 rare soft tissue tumor 10.0

Graphical network of the top 20 diseases related to Small Intestinal Sarcoma:



Diseases related to Small Intestinal Sarcoma

Symptoms & Phenotypes for Small Intestinal Sarcoma

GenomeRNAi Phenotypes related to Small Intestinal Sarcoma according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-102 9.53 KIT
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-126 9.53 EWSR1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.53 EWSR1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-140 9.53 EWSR1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 9.53 EWSR1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.53 KIT
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.53 KIT
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.53 EWSR1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.53 WT1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-35 9.53 WT1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 9.53 KIT
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 9.53 EWSR1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.53 EWSR1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.53 EWSR1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 9.53 EWSR1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.53 EWSR1

MGI Mouse Phenotypes related to Small Intestinal Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.8 ANO1 KIT KLK3 NTRK1 PDGFRA WT1
2 no phenotypic analysis MP:0003012 9.73 CD68 KIT NTRK1 PDGFRA PTPRC WT1
3 normal MP:0002873 9.63 KIT KLK3 NTRK1 PDGFRA PTPRC WT1
4 renal/urinary system MP:0005367 9.35 ANO1 KIT PDGFRA PTPRC WT1
5 respiratory system MP:0005388 9.02 ANO1 KIT PDGFRA PTPRC WT1

Drugs & Therapeutics for Small Intestinal Sarcoma

Search Clinical Trials , NIH Clinical Center for Small Intestinal Sarcoma

Genetic Tests for Small Intestinal Sarcoma

Anatomical Context for Small Intestinal Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Small Intestinal Sarcoma:

19
Small Intestine

MalaCards organs/tissues related to Small Intestinal Sarcoma:

40
Small Intestine, Myeloid, Bone Marrow, Ovary, Thyroid, Skin

Publications for Small Intestinal Sarcoma

Articles related to Small Intestinal Sarcoma:

(show top 50) (show all 100)
# Title Authors PMID Year
1
Primary Ewing's sarcoma of the small intestine. 61
33486963 2021
2
[Myeloid sarcoma of the small intestine with CBFβ-MYH11 as the primary manifestation of acute myeloid leukemia with inv(16)and+22: a case report]. 61
33190452 2020
3
Primary granulocytic sarcoma of the small intestine diagnosed by single-balloon enteroscopy: A case report. 61
31858650 2020
4
[Epithelioid inflammatory myofibroblastic sarcoma of the small intestine: report of two cases]. 61
31594049 2019
5
Myeloid sarcoma of the small intestine in a patient without overt acute myeloid leukaemia: a challenging diagnosis of a rare condition. 61
29848520 2018
6
Follicular dendritic cell sarcoma of the small intestine detected by double-balloon enteroscopy. 61
28543909 2017
7
Primary Myeloid Sarcoma of the Small Intestine: Case Report and Literature Review. 61
27509642 2016
8
Granulocytic sarcoma of the small intestine in a patient with chronic myelomonocytic leukemia. 61
25251682 2014
9
A rare case of ewing's sarcoma of the small intestine. 61
23336641 2013
10
The utility of balloon enteroscopy in the diagnosis of histiocytic sarcoma of the small intestine: a case report. 61
23464970 2013
11
Ewing's sarcoma of the small intestine misdiagnosed as a voluminous pedunculated uterine leiomyoma. 61
22410473 2012
12
Mast cell sarcoma of the small intestine: a case report. 61
21778298 2011
13
Low-grade fibromyxoid sarcoma of the small intestine: report of 4 cases with molecular cytogenetic confirmation. 61
21677541 2011
14
Donor cell leukemia following unrelated donor bone marrow transplantation for primary granulocytic sarcoma of the small intestine. 61
21328426 2011
15
Management of monophasic synovial sarcoma of the small intestine. 61
21333201 2010
16
Granulocytic sarcoma of the small intestine: an unusual presentation of acute myelogenous leukaemia. 61
20209703 2010
17
Myeloid sarcoma of the small bowel associated with a CBFbeta/MYH11 fusion and inv(16)(p13q22): a case report. 61
19638550 2009
18
[Histiocytic sarcoma of the small intestine: Report of one case]. 61
19543651 2009
19
Clear-cell sarcoma of the small intestine detected by FDG-PET/CT during comprehensive examination of an inflammatory reaction. 61
19262017 2009
20
Isolated granulocytic sarcoma of the small intestine successfully treated with chemotherapy and bone marrow transplantation. 61
18365139 2008
21
Primitive neurectodermal tumors: a case of extraosseous Ewing's sarcoma of the small intestine and review of the literature. 61
17309187 2006
22
Granulocytic sarcoma of the small intestine. 61
17090205 2006
23
Granulocytic sarcoma of the small intestine in a child without leukemia: report of a case with cytologic findings and immunophenotyping pitfalls. 61
15471256 2004
24
Eosinophilic gastroenteritis or eosinophilic chloroma? 61
15345900 2004
25
Granulocytic sarcoma of the small intestine with CBFbeta/MYH11 fusion gene: report of an aleukaemic case and review of the literature. 61
12859999 2003
26
Ewing sarcoma of the small intestine. 61
11878783 2001
27
Treatment of solid tumors following allogeneic bone marrow transplantation. 61
10808212 2000
28
[Isolated Kaposi sarcoma of the small intestine disclosed by occlusion in an HIV-positive patient]. 61
9033738 1996
29
Granulocytic sarcoma of the small intestine preceding acute myelomonocytic leukemia with abnormal eosinophils and inv(16). 61
3180024 1988
30
Granulocytic sarcoma of the small intestine: a case report. 61
3194190 1988
31
Multiple immunoblastic sarcoma of the small intestine following renal transplantation. 61
7020183 1981
32
Unusual histiocytic tumor of the small intestine. 61
6249716 1980
33
[Primary Hodgkin's sarcoma of the small intestine in the sprue syndrome with steatorrhea]. 61
860533 1977
34
[Reticular cell sarcoma of the small intestine with metastasis to the thyroid gland]. 61
323001 1977
35
[Sarcomas of the small intestine]. 61
857200 1977
36
[Hemoperitoneum in angioblastic sarcoma of the small intestine. Report of a case with a 5-year healing period]. 61
1034380 1976
37
[Eosinophilia and sarcoma of the small intestine (author's transl)]. 61
933987 1976
38
[Complications of sarcoma of the small intestine]. 61
1228317 1975
39
[Radiographic findings of primary reticulum cell sarcoma of the small intestine]. 61
1094155 1975
40
[2 cases of sarcoma of the small intestine with successful surgical treatment]. 61
4606078 1974
41
[Long-term celiac disease complicated by primary reticular sarcoma of the small intestine]. 61
4618728 1974
42
[Case of sarcoma of the small intestine mesentery complicated by hemorrhage]. 61
4541681 1973
43
Sarcoma of the small intestine. 61
5535906 1970
44
[Sarcoma of the small intestine]. 61
5419555 1970
45
[Perforative syndrome associated with development of lympho-reticulo-sarcoma of the small intestine]. 61
4906748 1968
46
[16 years of follow-up on a patient with sarcoma of the small intestine]. 61
5721608 1968
47
[2 new cases of steatorrhea revealing a reticulo-sarcoma of the small intestine]. 61
4878377 1968
48
A case of Kaposi's Sarcoma of the small intestine. 61
6078917 1967
49
[A rare case of sarcoma of the small intestine]. 61
6000647 1966
50
[On a rare case of reticulum cell sarcoma of the small intestine and ovary]. 61
5334166 1966

Variations for Small Intestinal Sarcoma

Expression for Small Intestinal Sarcoma

Search GEO for disease gene expression data for Small Intestinal Sarcoma.

Pathways for Small Intestinal Sarcoma

GO Terms for Small Intestinal Sarcoma

Cellular components related to Small Intestinal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.55 PTPRC PDGFRA NTRK1 KIT ANO1
2 receptor complex GO:0043235 9.13 PDGFRA NTRK1 KIT
3 cell surface GO:0009986 8.92 PTPRC PDGFRA NTRK1 KIT

Biological processes related to Small Intestinal Sarcoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.7 PTPRC PDGFRA NTRK1
2 protein autophosphorylation GO:0046777 9.69 PDGFRA NTRK1 KIT
3 peptidyl-tyrosine phosphorylation GO:0018108 9.61 PDGFRA NTRK1 KIT
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.58 PDGFRA NTRK1 KIT
5 T cell differentiation GO:0030217 9.56 PTPRC KIT
6 response to radiation GO:0009314 9.55 NTRK1 KIT
7 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.54 PDGFRA KIT
8 positive regulation of MAPK cascade GO:0043410 9.5 PTPRC NTRK1 KIT
9 adrenal gland development GO:0030325 9.49 WT1 PDGFRA
10 male genitalia development GO:0030539 9.48 WT1 PDGFRA
11 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.46 NTRK1 ANO1
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.43 PDGFRA NTRK1 KIT
13 positive regulation of phospholipase C activity GO:0010863 9.37 PDGFRA KIT
14 B cell differentiation GO:0030183 9.33 PTPRC NTRK1 KIT
15 positive regulation of kinase activity GO:0033674 9.13 PDGFRA NTRK1 KIT
16 hematopoietic progenitor cell differentiation GO:0002244 8.8 PTPRC PDGFRA KIT

Molecular functions related to Small Intestinal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.46 PDGFRA NTRK1 KIT ANO1
2 protein tyrosine kinase activity GO:0004713 9.13 PDGFRA NTRK1 KIT
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 PDGFRA NTRK1 KIT

Sources for Small Intestinal Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....