MCID: SML015
MIFTS: 32

Small Intestinal Sarcoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Small Intestinal Sarcoma

MalaCards integrated aliases for Small Intestinal Sarcoma:

Name: Small Intestinal Sarcoma 12 15 73
Sarcoma of the Small Intestine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5272
NCIt 50 C5335
UMLS 73 C1336007

Summaries for Small Intestinal Sarcoma

Disease Ontology : 12 A sarcoma and malignant tumor of small intestine that is located in the small intestine.

MalaCards based summary : Small Intestinal Sarcoma, also known as sarcoma of the small intestine, is related to clear cell sarcoma and leiomyoma. An important gene associated with Small Intestinal Sarcoma is IHH (Indian Hedgehog), and among its related pathways/superpathways are Innate Lymphoid Cell Differentiation Pathways and C-MYB transcription factor network. Affiliated tissues include the small intestine, small intestine and myeloid, and related phenotypes are Decreased human papilloma virus 16 (HPV16) pseudovirus infection and cardiovascular system

Related Diseases for Small Intestinal Sarcoma

Diseases related to Small Intestinal Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 clear cell sarcoma 29.6 IGF2 KIT
2 leiomyoma 28.6 CD34 IGF2 KIT
3 small intestine leiomyosarcoma 26.9 ADAM17 ANO1 CD34 GCG IGF2 IHH
4 small bowel fibrosarcoma 10.9
5 malignant anus melanoma 10.4 ADAM17 KIT
6 sarcoma 10.3
7 osteochondrosis 10.2 IGF2 IHH
8 congenital mesoblastic nephroma 10.2 IGF2 KIT
9 myeloid sarcoma 10.0
10 endocrine pancreas disease 10.0 GCG IGF2
11 ovarian brenner tumor 10.0 ANO1 KIT
12 pancreas disease 10.0 GCG IGF2
13 gallbladder leiomyoma 10.0 CD34 KIT
14 lung leiomyosarcoma 10.0 CD34 KIT
15 deep leiomyoma 9.9 CD34 KIT
16 extracutaneous mastocytoma 9.9 CD34 KIT
17 gallbladder sarcoma 9.9 CD34 KIT
18 prostate leiomyosarcoma 9.9 CD34 KIT
19 diffuse cutaneous mastocytosis 9.9 CD34 KIT
20 sarcomatoid squamous cell skin carcinoma 9.9 CD34 KIT
21 breast angiosarcoma 9.9 CD34 KIT
22 leukemia 9.9
23 plexiform schwannoma 9.9 CD34 KIT
24 conventional fibrosarcoma 9.9 CD34 KIT
25 senile angioma 9.9 CD34 KIT
26 angiomyoma 9.9 CD34 KIT
27 spindle cell liposarcoma 9.9 CD34 KIT
28 leiomyosarcoma 9.8 IGF2 KIT
29 mesenchymal cell neoplasm 9.8 CD34 KIT
30 spindle cell synovial sarcoma 9.8 CD34 KIT
31 leiomyoma, uterine 9.7
32 sarcoma, synovial 9.7
33 chronic myelomonocytic leukemia 9.7
34 mast-cell sarcoma 9.7
35 extraosseous ewing's sarcoma 9.7
36 monophasic synovial sarcoma 9.7
37 follicular dendritic cell sarcoma 9.7
38 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.7
39 pdgfrb-associated chronic eosinophilic leukemia 9.7
40 histiocytic sarcoma 9.7
41 connective tissue cancer 9.7 CD34 KIT
42 periosteal osteogenic sarcoma 9.7 CD34 IGF2
43 organ system benign neoplasm 9.7 CD34 KIT
44 leukocyte disease 9.7 CD34 KIT
45 dermatofibrosarcoma protuberans 9.6 CD34 KIT
46 cell type cancer 9.4 CD34 KIT
47 muscle cancer 9.3 CD34 IGF2 KIT
48 liver leiomyoma 9.2 ANO1 CD34 KIT
49 meninges sarcoma 9.2 CD34 GCG IGF2
50 gastrointestinal system cancer 8.8 ADAM17 CD34 IGF2 KIT

Graphical network of the top 20 diseases related to Small Intestinal Sarcoma:



Diseases related to Small Intestinal Sarcoma

Symptoms & Phenotypes for Small Intestinal Sarcoma

GenomeRNAi Phenotypes related to Small Intestinal Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human papilloma virus 16 (HPV16) pseudovirus infection GR00306-A 8.92 GCG IGF2 IHH KIT

MGI Mouse Phenotypes related to Small Intestinal Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 IGF2 IHH KIT ADAM17 ANO1
2 digestive/alimentary MP:0005381 9.77 IGF2 IHH KIT ADAM17 ANO1
3 integument MP:0010771 9.72 IGF2 KIT ADAM17 ANO1 CD34
4 limbs/digits/tail MP:0005371 9.56 IGF2 IHH KIT ADAM17
5 muscle MP:0005369 9.55 IGF2 IHH KIT ADAM17 ANO1
6 respiratory system MP:0005388 9.35 IHH KIT ADAM17 ANO1 IGF2
7 skeleton MP:0005390 9.02 IGF2 IHH KIT ADAM17 ANO1

Drugs & Therapeutics for Small Intestinal Sarcoma

Search Clinical Trials , NIH Clinical Center for Small Intestinal Sarcoma

Genetic Tests for Small Intestinal Sarcoma

Anatomical Context for Small Intestinal Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Small Intestinal Sarcoma:

19
The Small Intestine

MalaCards organs/tissues related to Small Intestinal Sarcoma:

41
Small Intestine, Myeloid

Publications for Small Intestinal Sarcoma

Articles related to Small Intestinal Sarcoma:

(show all 11)
# Title Authors Year
1
Myeloid sarcoma of the small intestine in a patient without overt acute myeloid leukaemia: a challenging diagnosis of a rare condition. ( 29848520 )
2018
2
Follicular dendritic cell sarcoma of the small intestine detected by double-balloon enteroscopy. ( 28543909 )
2017
3
Primary Myeloid Sarcoma of the Small Intestine: Case Report and Literature Review. ( 27509642 )
2016
4
Granulocytic sarcoma of the small intestine in a patient with chronic myelomonocytic leukemia. ( 25251682 )
2014
5
The utility of balloon enteroscopy in the diagnosis of histiocytic sarcoma of the small intestine: a case report. ( 23464970 )
2013
6
Ewing's sarcoma of the small intestine misdiagnosed as a voluminous pedunculated uterine leiomyoma. ( 22410473 )
2012
7
Mast cell sarcoma of the small intestine: a case report. ( 21778298 )
2011
8
Management of monophasic synovial sarcoma of the small intestine. ( 21333201 )
2010
9
Clear-cell sarcoma of the small intestine detected by FDG-PET/CT during comprehensive examination of an inflammatory reaction. ( 19262017 )
2009
10
Primitive neurectodermal tumors: a case of extraosseous Ewing's sarcoma of the small intestine and review of the literature. ( 17309187 )
2006
11
Granulocytic sarcoma of the small intestine preceding acute myelomonocytic leukemia with abnormal eosinophils and inv(16). ( 3180024 )
1988

Variations for Small Intestinal Sarcoma

Expression for Small Intestinal Sarcoma

Search GEO for disease gene expression data for Small Intestinal Sarcoma.

Pathways for Small Intestinal Sarcoma

Pathways related to Small Intestinal Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.27 CD34 KIT
2 11.21 CD34 KIT
3 11.13 CD34 KIT
4 10.97 IGF2 IHH
5 10.68 CD34 KIT
6 10.35 IGF2 KIT

GO Terms for Small Intestinal Sarcoma

Cellular components related to Small Intestinal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.17 ADAM17 ANO1 CD34 GCG IGF2 IHH
2 apical plasma membrane GO:0016324 9.13 ADAM17 ANO1 CD34

Biological processes related to Small Intestinal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.67 ANO1 IGF2 IHH KIT
2 hemopoiesis GO:0030097 9.4 CD34 KIT
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.32 IGF2 KIT
4 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.26 ANO1 GCG
5 negative regulation of apoptotic process GO:0043066 9.26 GCG IGF2 IHH KIT
6 cell motility GO:0048870 9.16 ADAM17 CD34
7 positive regulation of cell proliferation GO:0008284 8.92 ADAM17 IGF2 IHH KIT

Sources for Small Intestinal Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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