MCID: SML009
MIFTS: 55

Small Intestine Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Small Intestine Adenocarcinoma

MalaCards integrated aliases for Small Intestine Adenocarcinoma:

Name: Small Intestine Adenocarcinoma 12 15
Small Intestinal Adenocarcinoma 12 53 17
Adenocarcinoma of the Small Instestine 53 59
Adenocarcinoma of the Small Bowel 53 59
Adenocarcinoma of Small Instestine 53
Adenocarcinoma of Small Intestine 12
Adenocarcinoma of Small Bowel 53
Small Bowel Adenocarcinoma 53

Classifications:



External Ids:

Disease Ontology 12 DOID:4906
NCIt 50 C7888
ICD10 via Orphanet 34 D01.4
UMLS via Orphanet 73 C0278803
Orphanet 59 ORPHA104075
UMLS 72 C0278803

Summaries for Small Intestine Adenocarcinoma

NIH Rare Diseases : 53 Small intestine adenocarcinoma is one type of small bowel cancer, usually occurring in the duodenum or jejunum, that begins in the gland cells. The small intestine is part of the body's digestive system, which also includes the esophagus, stomach, and large intestine. The exact cause is still unknown, but it may be due to DNA changes in the small intestine adenocarcinoma cells. The symptoms of small bowel tumors are often vague. The most common symptoms are pain in the belly (which may be the first symptom), weight loss, weakness, fatigue and low red blood cell counts (anemia). The treatment and prognosis for small intestine cancer depends on its stage (tumor size and site) and the presence of metastases. For early stage cancer, surgery may be all that is needed. For more advanced cancer chemotherapy or radiation therapy may be required. Please visit the National Cancer Institute website for additional information: Small Intestine Cancer Treatment (PDQR)-Patient Version

MalaCards based summary : Small Intestine Adenocarcinoma, also known as small intestinal adenocarcinoma, is related to adenoma and attenuated familial adenomatous polyposis. An important gene associated with Small Intestine Adenocarcinoma is USP10 (Ubiquitin Specific Peptidase 10), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Endometrial cancer. The drugs Oxaliplatin and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and t cells, and related phenotypes are mortality/aging and neoplasm

Disease Ontology : 12 A small intestine carcinoma that derives from epithelial cells of glandular origin.

Related Diseases for Small Intestine Adenocarcinoma

Diseases in the Large Intestine Adenocarcinoma family:

Small Intestine Adenocarcinoma

Diseases related to Small Intestine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 adenoma 29.6 SMAD4 MSH2 MLH1
2 attenuated familial adenomatous polyposis 29.5 MSH6 MSH2
3 colorectal adenocarcinoma 29.1 MSH6 MSH2 MLH1
4 lynch syndrome 29.0 MSH6 MSH2 MLH1
5 gastric cancer 28.4 SMAD4 MUC6 MSH2 MLH1
6 small intestine cancer 28.4 MUC6 MSH6 MSH2 MLH1
7 gastrointestinal system cancer 28.3 SMAD4 MSH6 MSH2 MLH1
8 familial adenomatous polyposis 28.2 SMAD4 MSH6 MSH2 MLH1
9 colorectal cancer 27.9 SMAD4 MUC6 MSH6 MSH2 MLH1
10 adenocarcinoma 10.7
11 duodenum adenocarcinoma 10.3
12 polyposis syndrome, hereditary mixed, 1 10.2 MUC6 MLH1
13 adenomyoma 10.2 MUC6 MLH1
14 colorectal cancer, hereditary nonpolyposis, type 7 10.2 MSH2 MLH1
15 lower lip cancer 10.2 MSH2 MLH1
16 anal fistula 10.2 MSH2 MLH1
17 deficiency anemia 10.2
18 ileus 10.2
19 crohn's disease 10.1
20 melanocytic nevus syndrome, congenital 10.1 MSH2 MLH1
21 childhood kidney cell carcinoma 10.1 MSH2 MLH1
22 colorectal cancer, hereditary nonpolyposis, type 4 10.1 MSH2 MLH1
23 gastrointestinal carcinoma 10.1
24 iron deficiency anemia 10.1
25 intussusception 10.1
26 tubular adenocarcinoma 10.1
27 intestinal benign neoplasm 10.1 MSH2 MLH1
28 mixed ductal-endocrine carcinoma 10.0 SMAD4 MUC6
29 keratoacanthoma 10.0 MSH2 MLH1
30 small intestine lymphoma 10.0
31 peritonitis 10.0
32 acute sensory ataxic neuropathy 10.0
33 pancreatic ductal carcinoma 10.0 SMAD4 MUC6
34 colorectal cancer 1 10.0 MUC6 MSH2
35 familial colorectal cancer 9.9 MSH2 MLH1
36 celiac disease 1 9.9
37 osteogenic sarcoma 9.9
38 familial adenomatous polyposis 2 9.9
39 lymphoma 9.9
40 crohn's colitis 9.9
41 neutropenia 9.9
42 gastritis 9.9
43 lymphocytic gastritis 9.9
44 peripheral nervous system disease 9.9
45 active peptic ulcer disease 9.9
46 neuropathy 9.9
47 colorectal cancer 5 9.9 MSH6 MLH1
48 gastric leiomyoma 9.9 MSH6 MLH1
49 exanthem 9.9
50 colorectal adenoma 9.9 MSH2 MLH1

Graphical network of the top 20 diseases related to Small Intestine Adenocarcinoma:



Diseases related to Small Intestine Adenocarcinoma

Symptoms & Phenotypes for Small Intestine Adenocarcinoma

MGI Mouse Phenotypes related to Small Intestine Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.5 CPS1 MLH1 MSH2 MSH6 S100A14 SMAD4
2 neoplasm MP:0002006 8.92 MLH1 MSH2 MSH6 SMAD4

Drugs & Therapeutics for Small Intestine Adenocarcinoma

Drugs for Small Intestine Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 4 61825-94-3 5310940 9887054 43805 6857599
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
4
Ondansetron Approved Phase 3 99614-02-5 4595
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
6
Fluorouracil Approved Phase 3 51-21-8 3385
7 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
8 Gastrointestinal Agents Phase 3
9 Cola Phase 3
10 Antineoplastic Agents, Hormonal Phase 3
11 Liver Extracts Phase 3
12 Hormone Antagonists Phase 3
13 Neurotransmitter Agents Phase 3
14 Antiemetics Phase 3
15 Central Nervous System Depressants Phase 3
16 HIV Protease Inhibitors Phase 3
17 Anti-Inflammatory Agents Phase 3
18 Serotonin Antagonists Phase 3
19 Tranquilizing Agents Phase 3
20 Psychotropic Drugs Phase 3
21 Hormones Phase 3
22 glucocorticoids Phase 3
23 Peripheral Nervous System Agents Phase 3
24 Anti-Anxiety Agents Phase 3
25 Serotonin Agents Phase 3
26 Dermatologic Agents Phase 3
27 Antipruritics Phase 3
28
protease inhibitors Phase 3
29 Antipsychotic Agents Phase 3
30 Autonomic Agents Phase 3
31 BB 1101 Phase 3
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
33 Analgesics Phase 3
34 Anesthetics, Intravenous Phase 3
35 Narcotics Phase 3
36 Analgesics, Opioid Phase 3
37 Adjuvants, Anesthesia Phase 3
38 Anesthetics, General Phase 3
39 Anesthetics Phase 3
40
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
41
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
42
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
43
Bevacizumab Approved, Investigational Phase 2 216974-75-3
44
Panitumumab Approved, Investigational Phase 2 339177-26-3 50070211
45
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
46
Hydroxyurea Approved Phase 2 127-07-1 3657
47
Lenograstim Approved, Investigational Phase 2 135968-09-1
48
Floxuridine Approved Phase 2 50-91-9 5790
49
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
50
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Study of the Relationship Between the Rate of Residual Platinum in the Blood and the Incidence of Persistent Neurotoxicity in Patients Treated for Gastrointestinal Cancer With Oxaliplatin Unknown status NCT00274885 Phase 4 oxaliplatin
2 Endoscopic Detection of Small Bowel Dysplasia and Cancer in Patients With Jejuna or Ileal Crohn Disease : Prospective Study in a Cohort of High Risk Patients Completed NCT01180452 Phase 4
3 A Randomized Phase III Double-Blind Study Of Ondansetron And Dexamethasone Versus Ondansetron And Placebo In The Prophylaxis Of Radiation-Induced Emesis Completed NCT00016380 Phase 3 dexamethasone;ondansetron
4 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
5 PRODIGE 33 - BALLAD - Phase III Trial Investigating the Potential Benefit of Adjvant Chemotherapy for Small Bowel Adenocarcinoma Not yet recruiting NCT02502370 Phase 3 observation alone;LV5FU2;FOLFOX
6 A Phase II Trial of Pharmacogenetic-Based Dosing of Irinotecan, Oxaliplatin, and Capecitabine as First-Line Therapy for Advanced Small Bowel Adenocarcinoma Completed NCT00433550 Phase 2 capecitabine;irinotecan hydrochloride;oxaliplatin
7 Phase II Study of Bevacizumab Combined With Capecitabine and Oxaliplatin (CAPOX) in Patients With Advanced Adenocarcinoma of the Small Bowel or Ampulla of Vater Completed NCT01208103 Phase 2 Capecitabine;Oxaliplatin
8 Phase II Study of Panitumumab in KRAS Wild-type Locally Advanced or Metastatic Adenocarcinoma of the Small Bowel or Ampulla of Vater Completed NCT01202409 Phase 2 Panitumumab
9 A Pilot Phase I/II Trial of Enteral Wallstents for Colonic Obstruction in the Setting of Malignancy Completed NCT00004911 Phase 1, Phase 2
10 A Pilot Phase I/II Trial of Enteral Wallstents for Duodenal Obstruction in the Setting of Malignancy Completed NCT00004910 Phase 1, Phase 2
11 Octreotide for Palliation of Inoperable Bowel Obstruction: A Phase II Study Completed NCT00004895 Phase 2 octreotide acetate
12 A Phase II Study of Capecitabine and Oxaliplatin (XELOX) in Adenocarcinoma of the Small Bowel and Ampulla of Vater Completed NCT00354887 Phase 2 Capecitabine;Oxaliplatin
13 Phase II Trial of 2-Fluorouracil Recombinant Alpha-2a-Interferon and Intravenous Hydroxyurea With Filgrastim in Patients With Refractory GI Malignancies Grant Application Title: Parenteral Hydroxyurea: A Modulator in Pancreatic Cancer Completed NCT00019474 Phase 2 fluorouracil;hydroxyurea
14 Pilot Study of Intraperitoneal (IP) Therapy With Cisplatin or Carboplatin and Floxuridine (FUdR) as Consolidation for Ovarian and Gastrointestinal Malignancies Completed NCT00005049 Phase 2 carboplatin;cisplatin;floxuridine
15 A Phase II Study Of Hepatic Arterial Infusion Of Melphalan With Venous Filtration Via Peripheral Hepatic Perfusion (PHP) For Unresectable Primary And Metastatic Cancers Of The Liver Completed NCT00096083 Phase 2 isolated perfusion;melphalan
16 Pilot Study to Investigate the Safety and Efficacy of Avelumab Monotherapy in Patients With Advanced or Metastatic Adenocarcinoma of the Small Intestine Active, not recruiting NCT03000179 Phase 2 Avelumab
17 A Multicenter Phase II Study of Pembrolizumab (MK-3475) in Patients With Advanced Small Bowel Adenocarcinomas Active, not recruiting NCT02949219 Phase 2
18 A Trial Of Vaccination With The Carcinoembryonic Antigen (CEA) Peptide Cap 1-6D With Montanide ISA 51 Adjuvant Or Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) In HLA-A2+ Patients With CEA Producing Adenocarcinomas Of Gastrointestinal (GI) Tract Origin Terminated NCT00012246 Phase 2
19 Phase Ib Trial of Gemcitabine and Oxaliplatin (GEMOX) With Erlotinib in Patients With Advanced Biliary Tract Cancer. Completed NCT00987766 Phase 1 erlotinib hydrochloride;gemcitabine hydrochloride;oxaliplatin
20 Pilot Study of Oxaliplatin in Combination With Capecitabine in Adult Cancer Patients Completed NCT00019773 Phase 1 capecitabine;oxaliplatin
21 A Phase I Study of Intraperitoneal Oxaliplatin Alone and in Combination With Intraperitoneal Floxuridine and Leucovorin in Patients With Advanced Metastatic Cancer Confined to the Peritoneal Cavity Completed NCT00005860 Phase 1 floxuridine;leucovorin calcium;oxaliplatin
22 Phase I Clinical Study of Every Three Week Irinotecan With Oral Capecitabine Given Twice Daily for Two Weeks Out of Three in Patients With Gastrointestinal and Other Solid Malignancies Completed NCT00003867 Phase 1 capecitabine;irinotecan hydrochloride
23 A Phase I Dose-Escalating Study of Recombinant Human Interleukin-12 (NSC # 672423) Administered by Intraperitoneal Infusion in Refractory Advanced Stage Ovarian Cancer and Other Abdominal Carcinomatosis Completed NCT00003439 Phase 1
24 Phase I Study of Intraperitoneal Recombinant Human Interleukin-12 (rhIL-12) in Patients With Peritoneal Carcinomatosis, Associated With Mullerian and Gastrointestinal Carcinomas Completed NCT00003046 Phase 1
25 Pilot Study of Gemcitabine and IORT/EBRT in Locally Advanced Upper Gastrointestinal Malignancies Completed NCT00544193 Phase 1 gemcitabine hydrochloride
26 A Pharmacogenetic-Based Phase I Trial of Irinotecan, 5-Fluorouracil, and Leucovorin (FOLFIRI) in Patients With Advanced Gastrointestinal Cancer Completed NCT00654160 Phase 1 fluorouracil;irinotecan hydrochloride;leucovorin calcium
27 A Phase I, Multi-Dose Study of RAV12 (ANTI-RAAG12 MAB) in Patients With Metastatic or Recurrent Adenocarcinoma Completed NCT00101972 Phase 1
28 Phase I Study of T Cells Modified With Chimeric AntiCEA Immunoglobulin-T Cell Receptors (IgTCR) in Adenocarcinoma Completed NCT00004178 Phase 1
29 A Phase I Clinical Trial To Assess The Safety And Efficacy Of Intraperitoneal PV701 Administrations In Patients With Advanced Or Recurrent Malignancy Largely Confined To The Peritoneal Cavity Completed NCT00055705 Phase 1
30 A Phase I Study of Oral Fluoropyrimidine Capecitabine (Xeloda Roche) Combined With Intravenous Cisplatin in Patients With Advanced Cancer of the Digestive System Completed NCT00010023 Phase 1 capecitabine;cisplatin
31 A Phase I, Pharmacokinetic, and Biologic Correlative Study of R115777 (NSC 702818) and Herceptin in Patients With Advanced Cancer Completed NCT00005842 Phase 1 tipifarnib
32 Phase I Pharmacokinetic Trial of Thalidomide and Docetaxel: A Regimen Based on Anti-Angiogenic Therapeutic Principles Completed NCT00049296 Phase 1 docetaxel;thalidomide
33 Prospective Randomized Comparison Between Axial- and Lateral-viewing Capsule Endoscopy Systems in Celiac Patients: a Pilot Study Unknown status NCT03095573
34 A Capsule Endoscopy and Double Balloon Enteroscopy Sequential Approach for Early Detection of Gastrointestinal Tumors in Celiac Disease: a Prospective Trial Unknown status NCT02325232
35 Visceral Lymphatic Mapping Project: A Pilot Study Completed NCT00489515
36 Improving Palliative Care for Patients With Cancer Completed NCT00253383
37 Study of Survival and Description of Care for Patients With Degenerate Vaterian Ampulloma Recruiting NCT03800212 treatment for ampullary adenocarcinoma
38 Phenotyping of Small Bowel Adenocarcinoma Active, not recruiting NCT02976090

Search NIH Clinical Center for Small Intestine Adenocarcinoma

Genetic Tests for Small Intestine Adenocarcinoma

Anatomical Context for Small Intestine Adenocarcinoma

MalaCards organs/tissues related to Small Intestine Adenocarcinoma:

41
Small Intestine, Liver, T Cells, Colon, Endothelial, Lymph Node

Publications for Small Intestine Adenocarcinoma

Articles related to Small Intestine Adenocarcinoma:

(show top 50) (show all 102)
# Title Authors PMID Year
1
Detection of the Bacteroides fragilis toxin gene in sheep with and without small intestinal adenocarcinoma. 38
31378159 2019
2
Celiac disease: a comprehensive current review. 38
31331324 2019
3
Assessment of the external validity of the AJCC 8th staging system for small intestinal adenocarcinoma: a time to reconsider the role of tumor location? 38
31183191 2019
4
DNA mismatch repair deficiency but not ARID1A loss is associated with prognosis in small intestinal adenocarcinoma. 38
30381262 2019
5
Retrospective study of survival time and prognostic factors for dogs with small intestinal adenocarcinoma treated by tumor excision with or without adjuvant chemotherapy. 38
30605388 2019
6
Dual loss of USP10 and p14ARF protein expression is associated with poor prognosis in patients with small intestinal adenocarcinoma. 38
30375264 2018
7
[A Case of Intussusception in the Jejunum Due to Small Intestinal Adenocarcinoma]. 38
30237385 2018
8
Influence of marital status on small intestinal adenocarcinoma survival: an analysis of the Surveillance, Epidemiology, and End Results (SEER) database. 38
30532589 2018
9
Pancreatic non-functioning neuroendocrine tumor: a new entity genetically related to Lynch syndrome. 38
29184699 2017
10
Could the PD-1 Pathway Be a Potential Target for Treating Small Intestinal Adenocarcinoma? 38
28821192 2017
11
Metastatic intestinal adenocarcinoma to a lymph node involved by follicular lymphoma: The importance of looking beyond the apparent. 38
28476376 2017
12
Lynch syndrome-related small intestinal adenocarcinomas. 38
28206961 2017
13
Value of SATB2 immunostaining in the distinction between small intestinal and colorectal adenocarcinomas. 38
27169755 2016
14
[A Case of Ileocecal Intussusception Due to Small Intestinal Adenocarcinoma]. 38
28133155 2016
15
Clinicopathologic and prognostic associations of KRAS and BRAF mutations in small intestinal adenocarcinoma. 38
26892442 2016
16
[A Case of Long-Term Survival in a Patient with Small Intestinal Adenocarcinoma with Peritoneal Dissemination]. 38
26809539 2016
17
Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) as a Useful Immunohistochemical Marker for the Diagnosis of Adenocarcinoma of Small Intestine. 38
26855452 2015
18
[A Case of Small Bowel Cancer Treated with Laparoscopic Surgery]. 38
26805147 2015
19
Prognostic Significance of CD44v6, CD133, CD166, and ALDH1 Expression in Small Intestinal Adenocarcinoma. 38
25710579 2015
20
[Four Cases of Primary Small Intestinal Cancer]. 38
26805145 2015
21
Increased risk of additional cancers among patients with gastrointestinal stromal tumors: A population-based study. 38
25930983 2015
22
SMALL INTESTINAL ADENOCARCINOMA WITH CARCINOMATOSIS IN A SWIFT FOX (VULPES VELOX). 38
26352968 2015
23
Lifestyle factors and small intestine adenocarcinoma risk: A systematic review and meta-analysis. 38
25736860 2015
24
Mucinous phenotype and CD10 expression of primary adenocarcinoma of the small intestine. 38
25759539 2015
25
Small bowel imaging in celiac disease. 38
25925931 2015
26
[A case of long-term survival of small intestinal adenocarcinoma treated by resection and chemotherapy]. 38
25731553 2014
27
Prognostic significance of CDX2 and mucin expression in small intestinal adenocarcinoma. 38
24603585 2014
28
Notch3 signaling is associated with MUC5AC expression and favorable prognosis in patients with small intestinal adenocarcinomas. 38
24810798 2014
29
Recovering a stuck capsule … and discovering a rare small-intestinal adenocarcinoma. 38
24679662 2014
30
[A case report of primary adenocarcinoma of the small intestine with peritoneal dissemination treated with multidisciplinary therapy]. 38
25129097 2014
31
S100A4 expression is a prognostic indicator in small intestine adenocarcinoma. 38
24062356 2014
32
Coexistence of granulomatous enteric inflammation and neoplasia in an adult sheep. 38
23456963 2013
33
Epithelial-mesenchymal transition phenotype is associated with patient survival in small intestinal adenocarcinoma. 38
24018801 2013
34
Molecular alterations of EGFR in small intestinal adenocarcinoma. 38
23644682 2013
35
Small intestinal adenocarcinoma: rarely considered, often missed? 38
23412393 2013
36
Loss of S100A14 expression is associated with the progression of adenocarcinomas of the small intestine. 38
23038644 2013
37
Expression of PI3K, PTEN and Akt in small intestinal adenocarcinoma detected by quantum dots-based immunofluorescence technology. 38
24240591 2013
38
Genome-wide gene expression profile of jejunal pouch mucosa as a gastric substitute. 38
22281974 2012
39
[A case of primary adenocarcinoma of small intestine responding to XELOX chemotherapy and leading to a partial metabolic response]. 38
22584343 2012
40
[Expression of Bcl-w protein in human small intestinal adenocarcinoma and effect of Bcl-w siRNA on apoptosis in intestinal adenocarcinoma HuTu-80 cells]. 38
22780970 2012
41
Small bowel adenocarcinoma complicating coeliac disease: a report of three cases and the literature review. 38
23243535 2012
42
Coeliac disease in endocrine diseases of autoimmune origin. 38
22744631 2012
43
High susceptibility to zymbal gland and intestinal carcinogenesis in diabetic Otsuka long-evans Tokushima Fatty rats. 38
22319230 2011
44
[A case report of multiple adenocarcinoma in small intestine after total gastrectomy by Roux-en-Y re-construction]. 38
22202278 2011
45
Surgical versus non-surgical treatment of feline small intestinal adenocarcinoma and the influence of metastasis on long-term survival in 18 cats (2000-2007). 38
22467965 2011
46
Genetics and epigenetics of small bowel adenocarcinoma: the interactions of CIN, MSI, and CIMP. 38
21297586 2011
47
Lack of HER2 overexpression and amplification in small intestinal adenocarcinoma. 38
21088150 2010
48
[A case report of primary adenocarcinoma of small intestine]. 38
21224715 2010
49
Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma. 38
20846270 2010
50
Small intestinal adenocarcinoma in common marmosets (Callithrix jacchus). 38
20460447 2010

Variations for Small Intestine Adenocarcinoma

Cosmic variations for Small Intestine Adenocarcinoma:

9 (show top 50) (show all 22429)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6971229 ZRSR2 small intestine,duodenum,carcinoma,adenocarcinoma c.611G>A p.S204N 23:15815730-15815730 24
2 COSM6973250 ZFHX3 small intestine,jejunum,carcinoma,adenocarcinoma c.1691C>T p.A564V 16:72958455-72958455 24
3 COSM6845179 ZFHX3 small intestine,jejunum,carcinoma,adenocarcinoma c.8576C>T p.T2859M 16:72794106-72794106 24
4 COSM6913839 WT1 small intestine,duodenum,carcinoma,adenocarcinoma c.538G>T p.D180Y 11:32428524-32428524 24
5 COSM1130534 U2AF1 small intestine,duodenum,carcinoma,adenocarcinoma c.692C>T p.S231L 21:43093133-43093133 24
6 COSM6917759 TSC2 small intestine,jejunum,carcinoma,adenocarcinoma c.3551C>A p.A1184E 16:2080318-2080318 24
7 COSM6968949 TSC2 small intestine,duodenum,carcinoma,adenocarcinoma c.710C>T p.P237L 16:2056705-2056705 24
8 COSM44218 TP53 small intestine,duodenum,carcinoma,adenocarcinoma c.536A>C p.H179P 17:7675076-7675076 24
9 COSM43970 TP53 small intestine,duodenum,carcinoma,adenocarcinoma c.380C>A p.S127Y 17:7675232-7675232 24
10 COSM10738 TP53 small intestine,duodenum,carcinoma,adenocarcinoma c.542G>A p.R181H 17:7675070-7675070 24
11 COSM10788 TP53 small intestine,jejunum,carcinoma,adenocarcinoma c.764T>G p.I255S 17:7674199-7674199 24
12 COSM5731186 TP53 small intestine,jejunum,carcinoma,adenocarcinoma c.1052A>G p.K351R 17:7670657-7670657 24
13 COSM4116810 TGFBR2 small intestine,jejunum,carcinoma,adenocarcinoma c.1277C>T p.A426V 3:30674127-30674127 24
14 COSM6961805 TGFBR1 small intestine,duodenum,carcinoma,adenocarcinoma c.1124C>A p.T375K 9:99144882-99144882 24
15 COSM6968905 TET2 small intestine,duodenum,carcinoma,adenocarcinoma c.1124A>G p.E375G 4:105235066-105235066 24
16 COSM6973233 TENT5C small intestine,jejunum,carcinoma,adenocarcinoma c.839A>G p.D280G 1:117623707-117623707 24
17 COSM6971222 SUZ12 small intestine,duodenum,carcinoma,adenocarcinoma c.1058C>A p.P353H 17:31988354-31988354 24
18 COSM25847 STK11 small intestine,duodenum,carcinoma,adenocarcinoma c.580G>A p.D194N 19:1220488-1220488 24
19 COSM6973254 STK11 small intestine,jejunum,carcinoma,adenocarcinoma c.719C>T p.S240L 19:1220702-1220702 24
20 COSM6968955 STAT3 small intestine,duodenum,carcinoma,adenocarcinoma c.635A>G p.Q212R 17:42337773-42337773 24
21 COSM6946712 STAG2 small intestine,duodenum,carcinoma,adenocarcinoma c.3018T>G p.F1006L 23:124083514-124083514 24
22 COSM1227526 SRC small intestine,duodenum,carcinoma,adenocarcinoma c.1460C>T p.P487L 20:37403228-37403228 24
23 COSM2087949 SPEN small intestine,duodenum,carcinoma,adenocarcinoma c.4586G>A p.R1529H 1:15930826-15930826 24
24 COSM6968895 SPEN small intestine,duodenum,carcinoma,adenocarcinoma c.617G>A p.R206H 1:15876414-15876414 24
25 COSM6959363 SOX9 small intestine,duodenum,carcinoma,adenocarcinoma c.242T>C p.L81P 17:72121633-72121633 24
26 COSM6968916 SMO small intestine,duodenum,carcinoma,adenocarcinoma c.1571C>T p.A524V 7:129210467-129210467 24
27 COSM6971224 SMARCA4 small intestine,duodenum,carcinoma,adenocarcinoma c.2647G>T p.G883C 19:11021755-11021755 24
28 COSM14123 SMAD4 small intestine,jejunum,carcinoma,adenocarcinoma c.1087T>A p.C363S 18:51065554-51065554 24
29 COSM988907 SMAD4 small intestine,duodenum,carcinoma,adenocarcinoma c.1612G>A p.E538K 18:51078420-51078420 24
30 COSM6972746 SMAD3 small intestine,duodenum,carcinoma,adenocarcinoma c.1027T>G p.F343V 15:67187382-67187382 24
31 COSM6023570 SMAD3 small intestine,duodenum,carcinoma,adenocarcinoma c.772G>A p.D258N 15:67181354-67181354 24
32 COSM6968957 SMAD2 small intestine,duodenum,carcinoma,adenocarcinoma c.938T>C p.L313S 18:47848534-47848534 24
33 COSM6959364 SMAD2 small intestine,duodenum,carcinoma,adenocarcinoma c.1298G>A p.S433N 18:47841933-47841933 24
34 COSM6968893 SH2B3 small intestine,duodenum,carcinoma,adenocarcinoma c.616G>A p.A206T 12:111418761-111418761 24
35 COSM6973235 SF3B1 small intestine,jejunum,carcinoma,adenocarcinoma c.1226C>A p.P409Q 2:197408011-197408011 24
36 COSM6968956 RPTOR small intestine,duodenum,carcinoma,adenocarcinoma c.2875T>C p.F959L 17:80925436-80925436 24
37 COSM2804280 RPTOR small intestine,duodenum,carcinoma,adenocarcinoma c.3104C>T p.T1035M 17:80945745-80945745 24
38 COSM5839152 RPS6KA4 small intestine,jejunum,carcinoma,adenocarcinoma c.806C>T p.A269V 11:64361902-64361902 24
39 COSM4638831 RPS6KA4 small intestine,duodenum,carcinoma,adenocarcinoma c.1355G>A p.R452H 11:64368724-64368724 24
40 COSM6961801 ROS1 small intestine,duodenum,carcinoma,adenocarcinoma c.1289G>A p.G430D 6:117389820-117389820 24
41 COSM6917742 REL small intestine,duodenum,carcinoma,adenocarcinoma c.323G>A p.R108Q 2:60901012-60901012 24
42 COSM6960242 RECQL4 small intestine,duodenum,carcinoma,adenocarcinoma c.1649C>T p.A550V 8:144514497-144514497 24
43 COSM181063 RAF1 small intestine,jejunum,carcinoma,adenocarcinoma c.770C>T p.S257L 3:12604200-12604200 24
44 COSM1536534 RAF1 small intestine,jejunum,carcinoma,adenocarcinoma c.776C>T p.S259F 3:12604194-12604194 24
45 COSM6968897 RAD54L small intestine,duodenum,carcinoma,adenocarcinoma c.1181G>A p.R394Q 1:46272477-46272477 24
46 COSM6954429 RAD50 small intestine,duodenum,carcinoma,adenocarcinoma c.3419G>A p.R1140H 5:132642261-132642261 24
47 COSM6968919 RAD21 small intestine,duodenum,carcinoma,adenocarcinoma c.1642G>A p.D548N 8:116849008-116849008 24
48 COSM6968969 PTPRT small intestine,duodenum,carcinoma,adenocarcinoma c.4300A>G p.T1434A 20:42081920-42081920 24
49 COSM6973262 PTPRS small intestine,jejunum,carcinoma,adenocarcinoma c.341G>T p.G114V 19:5273480-5273480 24
50 COSM6973259 PTPRS small intestine,jejunum,carcinoma,adenocarcinoma c.2698A>G p.T900A 19:5223094-5223094 24

Copy number variations for Small Intestine Adenocarcinoma from CNVD:

7 (show all 22)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 13776 1 1 39600000 Copy number LCK Small bowel adenocarcinoma
2 13777 1 1 39600000 Copy number MDS2 Small bowel adenocarcinoma
3 13778 1 1 39600000 Copy number PAX7 Small bowel adenocarcinoma
4 13779 1 1 39600000 Copy number PRDM16 Small bowel adenocarcinoma
5 13780 1 1 39600000 Copy number RPL22 Small bowel adenocarcinoma
6 13781 1 1 39600000 Copy number SDHB Small bowel adenocarcinoma
7 76578 13 32900000 93800000 Copy number LCP1 Small bowel adenocarcinoma
8 76579 13 32900000 93800000 Copy number LHFP Small bowel adenocarcinoma
9 76580 13 32900000 93800000 Copy number RB1 Small bowel adenocarcinoma
10 106872 17 1 6800000 Copy number USP6 Small bowel adenocarcinoma
11 180663 4 10900000 191273063 Copy number CHIC2 Small bowel adenocarcinoma
12 180664 4 10900000 191273063 Copy number FBXW7 Small bowel adenocarcinoma
13 180665 4 10900000 191273063 Copy number FIP1L1 Small bowel adenocarcinoma
14 180666 4 10900000 191273063 Copy number IL2 Small bowel adenocarcinoma
15 180667 4 10900000 191273063 Copy number KIT Small bowel adenocarcinoma
16 180668 4 10900000 191273063 Copy number PDGFRA Small bowel adenocarcinoma
17 180669 4 10900000 191273063 Copy number PHOX2B Small bowel adenocarcinoma
18 180670 4 10900000 191273063 Copy number RAP1GDS1 Small bowel adenocarcinoma
19 244962 9 1 51800000 Copy number FANCG Small bowel adenocarcinoma
20 244963 9 1 51800000 Copy number JAK2 Small bowel adenocarcinoma
21 244964 9 1 51800000 Copy number MLLT3 Small bowel adenocarcinoma
22 244965 9 1 51800000 Copy number PAX5 Small bowel adenocarcinoma

Expression for Small Intestine Adenocarcinoma

Search GEO for disease gene expression data for Small Intestine Adenocarcinoma.

Pathways for Small Intestine Adenocarcinoma

Pathways related to Small Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 USP10 MSH6 MSH2 MLH1
2
Show member pathways
12.48 SMAD4 MSH6 MSH2 MLH1
3 12.39 SMAD4 MSH6 MSH2 MLH1
4 11.93 USP10 MSH6 MSH2 MLH1
5 11.77 SMAD4 MSH6 MSH2
6
Show member pathways
11.48 MSH6 MSH2 MLH1
7 11.47 SMAD4 MSH6 MSH2 MLH1
8
Show member pathways
11.46 MSH6 MSH2
9 11.3 MSH6 MSH2 MLH1
10 11.23 MSH6 MSH2 MLH1
11 11.17 MSH6 MSH2
12
Show member pathways
11.14 MSH2 MLH1
13
Show member pathways
11.08 MSH2 MLH1
14 10.26 MSH6 MSH2 MLH1

GO Terms for Small Intestine Adenocarcinoma

Cellular components related to Small Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutSalpha complex GO:0032301 8.96 MSH6 MSH2
2 mismatch repair complex GO:0032300 8.8 MSH6 MSH2 MLH1

Biological processes related to Small Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.84 USP10 MSH6 MSH2 MLH1
2 DNA repair GO:0006281 9.81 USP10 MSH6 MSH2 MLH1
3 negative regulation of DNA recombination GO:0045910 9.56 MSH6 MSH2
4 determination of adult lifespan GO:0008340 9.55 MSH6 MSH2
5 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.54 MSH6 MSH2 MLH1
6 positive regulation of isotype switching to IgG isotypes GO:0048304 9.52 MSH2 MLH1
7 positive regulation of helicase activity GO:0051096 9.49 MSH6 MSH2
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.46 MSH2 MLH1
9 maintenance of DNA repeat elements GO:0043570 9.43 MSH6 MSH2
10 mismatch repair GO:0006298 9.43 MSH6 MSH2 MLH1
11 somatic hypermutation of immunoglobulin genes GO:0016446 9.33 MSH6 MSH2 MLH1
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MSH2 MLH1
13 interstrand cross-link repair GO:0036297 9.27 MSH6
14 pyrimidine dimer repair GO:0006290 9.18 MSH6
15 isotype switching GO:0045190 9.13 MSH6 MSH2 MLH1
16 meiotic mismatch repair GO:0000710 9.1 MSH6
17 somatic recombination of immunoglobulin gene segments GO:0016447 8.8 MSH6 MSH2 MLH1

Molecular functions related to Small Intestine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.71 SMAD4 MSH6 MSH2 MLH1
2 enzyme binding GO:0019899 9.69 MSH6 MSH2 MLH1
3 ATPase activity GO:0016887 9.63 MSH6 MSH2 MLH1
4 damaged DNA binding GO:0003684 9.52 MSH6 MSH2
5 DNA-dependent ATPase activity GO:0008094 9.49 MSH6 MSH2
6 ADP binding GO:0043531 9.48 MSH6 MSH2
7 four-way junction DNA binding GO:0000400 9.43 MSH6 MSH2
8 oxidized purine DNA binding GO:0032357 9.37 MSH6 MSH2
9 MutLalpha complex binding GO:0032405 9.32 MSH6 MSH2
10 single thymine insertion binding GO:0032143 9.26 MSH6 MSH2
11 single guanine insertion binding GO:0032142 9.16 MSH6 MSH2
12 mismatched DNA binding GO:0030983 9.13 MSH6 MSH2 MLH1
13 guanine/thymine mispair binding GO:0032137 8.8 MSH6 MSH2 MLH1

Sources for Small Intestine Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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