Small Intestine Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Small Intestine Benign Neoplasm

MalaCards integrated aliases for Small Intestine Benign Neoplasm:

Name: Small Intestine Benign Neoplasm ¹² ¹⁵

Neoplasm of the Small Intestine ²⁹

Neoplasm of Small Intestine ¹²

Small Intestinal Neoplasm ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7505

NCIt ⁴⁹ C4432

SNOMED-CT ⁶⁷ 126832004

UMLS ⁷¹ C0345832

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Summaries for Small Intestine Benign Neoplasm

MalaCards based summary : Small Intestine Benign Neoplasm, also known as neoplasm of the small intestine, is related to small intestine leiomyoma and small intestine leiomyosarcoma. An important gene associated with Small Intestine Benign Neoplasm is SPINK5 (Serine Peptidase Inhibitor Kazal Type 5), and among its related pathways/superpathways is Neuroscience. The drugs Linaclotide and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include small intestine, and related phenotypes are behavior/neurological and nervous system

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Related Diseases for Small Intestine Benign Neoplasm

Diseases related to Small Intestine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)

#	Related Disease	Score	Top Affiliating Genes
1	small intestine leiomyoma	32.5	KIT ANO1
2	small intestine leiomyosarcoma	31.8	KIT ANO1
3	duodenum cancer	31.1	SST SPINK5 MEN1
4	rare tumor	30.4	SST KIT
5	intestinal obstruction	30.1	SST KIT ANO1
6	neurilemmoma	29.8	KIT ENO2 ANO1
7	carcinoid syndrome	29.5	SYP SST MEN1 ENO2 CHGA
8	adenoma	29.3	SYP SST MEN1 CHGA APC
9	hemangioma	29.2	SYP MEN1 KIT ENO2 CHGA
10	small intestine neuroendocrine neoplasm	28.8	SSTR1 SST SPINK5 NONO MLF1 MIR3137
11	small intestine cancer	11.8
12	squamous cell carcinoma of the small intestine	10.8
13	appendiceal neoplasm	10.5	SPINK5 CHGA
14	tricuspid valve stenosis	10.5	SST SPINK5
15	primary hepatic neuroendocrine carcinoma	10.5	SYP CHGA
16	acinar cell cystadenocarcinoma	10.5	SYP CHGA
17	rectum neuroendocrine neoplasm	10.5	SYP SST
18	vulvar eccrine porocarcinoma	10.5	SYP CHGA
19	cervical large cell neuroendocrine carcinoma	10.5	SYP CHGA
20	glucagonoma	10.5	SST CHGA
21	mixed ductal-endocrine carcinoma	10.4	SYP CHGA
22	pancreatic serous cystadenocarcinoma	10.4	SYP CHGA
23	type c thymoma	10.4	SST KIT
24	meckel's diverticulum cancer	10.4
25	ileum cancer	10.4
26	jejunal cancer	10.4
27	vaginal tubulovillous adenoma	10.4	SYP CHGA
28	papillary thymic adenocarcinoma	10.4	SYP CHGA
29	breast papillary carcinoma	10.4	SYP CHGA
30	laryngeal neuroendocrine tumor	10.4	SYP CHGA
31	appendix adenocarcinoma	10.4	SYP CHGA
32	benign perivascular tumor	10.4	SYP KIT
33	deep leiomyoma	10.4	KIT ANO1
34	gastric liposarcoma	10.4	KIT ANO1
35	ectopic cushing syndrome	10.4	SYP SST
36	pulmonary large cell neuroendocrine carcinoma	10.4	SYP CHGA
37	vaginal adenoma	10.4	SYP CHGA
38	gastric leiomyoma	10.4	KIT ANO1
39	liver leiomyoma	10.4	KIT ANO1
40	gastric leiomyosarcoma	10.4	KIT ANO1
41	colon leiomyosarcoma	10.4	KIT ANO1
42	pancreatic acinar cell adenocarcinoma	10.4	SYP CHGA
43	familial isolated pituitary adenoma	10.4	MEN1 CDKN1B
44	pituitary infarct	10.4	SST MEN1
45	vaginal benign neoplasm	10.4	SYP CHGA
46	extra-adrenal pheochromocytoma	10.3	SYP CHGA
47	retroperitoneal leiomyosarcoma	10.3	KIT ANO1
48	chordoid meningioma	10.3	SYP CHGA
49	esophageal neuroendocrine tumor	10.3	SYP SPINK5 CHGA
50	cecal disease	10.3	SYP SPINK5 CHGA

Graphical network of the top 20 diseases related to Small Intestine Benign Neoplasm:

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Symptoms & Phenotypes for Small Intestine Benign Neoplasm

MGI Mouse Phenotypes related to Small Intestine Benign Neoplasm:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.65	ANO1 APC CDKN1B ENO2 HOOK3 KIT
2	nervous system	MP:0003631	9.36	ANO1 APC CDKN1B CHGA ENO2 IPMK

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Drugs & Therapeutics for Small Intestine Benign Neoplasm

Drugs for Small Intestine Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Linaclotide

Approved

Phase 4

851199-59-2

65351

2

Gastrointestinal Agents

Phase 4

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Single-dose Linaclotide for Capsule Endoscopy Preparation	Completed	NCT02465385	Phase 4	Linaclotide

Search NIH Clinical Center for Small Intestine Benign Neoplasm

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Genetic Tests for Small Intestine Benign Neoplasm

Genetic tests related to Small Intestine Benign Neoplasm:

#	Genetic test	Affiliating Genes
1	Neoplasm of the Small Intestine ²⁹

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Anatomical Context for Small Intestine Benign Neoplasm

MalaCards organs/tissues related to Small Intestine Benign Neoplasm:

⁴⁰

Small Intestine

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Publications for Small Intestine Benign Neoplasm

Articles related to Small Intestine Benign Neoplasm:

#	Title	Authors	PMID	Year
1	[Clinical analysis of primary small intestinal neoplasms in 305 cases]. ⁶¹	Yang WL...Wang YJ	18396694	2007
2	[A case of primary jejunal adenocarcinoma diagnosed by enteroscopy using pediatric colonoscope]. ⁶¹	Lee CH...Jeon YS	17132927	2006
3	Usefulness of MR imaging for diseases of the small intestine: comparison with CT. ⁶¹	Kim JH...Auh YH	11752928	2000
4	Imaging of primary small intestinal tumours by enteroclysis and CT with pathological correlation. ⁶¹	Gourtsoyiannis N...Mako E	9166558	1997
5	A case of extragenital choriocarcinoma in the jejunum. ⁶¹	Harada N...Nawata H	1858745	1991
6	Tumors of the small intestine. ⁶¹	Ashley SW...Wells SA	3285475	1988
7	Three cases of small-intestinal neoplasm with unusual clinical features. ⁶¹	RECHNITZER PA...BLAKE J	13059482	1953
8	Three cases of small intestinal neoplasm. ⁶¹	RECHNITZER P	13083804	1953

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Genes for Small Intestine Benign Neoplasm

Genes related to Small Intestine Benign Neoplasm (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SPINK5	Serine Peptidase Inhibitor Kazal Type 5	Protein Coding	7.13	DISEASES inferred ¹⁵
2	HOOK3	Hook Microtubule Tethering Protein 3	Protein Coding	6.77	DISEASES inferred ¹⁵
3	MIR3137	MicroRNA 3137	RNA Gene	6.41	DISEASES inferred ¹⁵
4	SST	Somatostatin	Protein Coding	6.35	DISEASES inferred ¹⁵
5	CHGA	Chromogranin A	Protein Coding	6.01	DISEASES inferred ¹⁵
6	MLF1	Myeloid Leukemia Factor 1	Protein Coding	5.99	DISEASES inferred ¹⁵
7	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	5.96	DISEASES inferred ¹⁵
8	SYP	Synaptophysin	Protein Coding	5.82	DISEASES inferred ¹⁵
9	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	5.72	DISEASES inferred ¹⁵
10	ANO1	Anoctamin 1	Protein Coding	5.68	DISEASES inferred ¹⁵
11	MEN1	Menin 1	Protein Coding	5.68	DISEASES inferred ¹⁵
12	IPMK	Inositol Polyphosphate Multikinase	Protein Coding	5.41	DISEASES inferred ¹⁵
13	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	5.41	DISEASES inferred ¹⁵
14	ENO2	Enolase 2	Protein Coding	5.38	DISEASES inferred ¹⁵
15	CDR2L	Cerebellar Degeneration Related Protein 2 Like	Protein Coding	5.36	DISEASES inferred ¹⁵
16	SSTR1	Somatostatin Receptor 1	Protein Coding	5.35	DISEASES inferred ¹⁵
17	NONO	Non-POU Domain Containing Octamer Binding	Protein Coding	5.35	DISEASES inferred ¹⁵

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Variations for Small Intestine Benign Neoplasm

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Expression for Small Intestine Benign Neoplasm

Search GEO for disease gene expression data for Small Intestine Benign Neoplasm.

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Pathways for Small Intestine Benign Neoplasm

Pathways related to Small Intestine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	11.46	SYP SSTR1 ENO2 ANO1

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GO Terms for Small Intestine Benign Neoplasm

Biological processes related to Small Intestine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell proliferation	GO:0008285	9.72	SSTR1 SST MEN1 CDKN1B APC
2	cell cycle arrest	GO:0007050	9.61	MLF1 CDKN1B APC
3	mast cell degranulation	GO:0043303	9.4	KIT CHGA
4	positive regulation of pseudopodium assembly	GO:0031274	9.37	KIT APC
5	myeloid progenitor cell differentiation	GO:0002318	9.26	MLF1 KIT
6	mast cell chemotaxis	GO:0002551	9.16	KIT CHGA
7	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO:0045736	9.13	MEN1 CDKN1B APC
8	mast cell cytokine production	GO:0032762	8.62	KIT CHGA

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Sources for Small Intestine Benign Neoplasm

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