Small Intestine Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Small Intestine Benign Neoplasm

MalaCards integrated aliases for Small Intestine Benign Neoplasm:

Name: Small Intestine Benign Neoplasm ¹² ¹⁵

Neoplasm of the Small Intestine ³⁰

Neoplasm of Small Intestine ¹²

Small Intestinal Neoplasm ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7505

NCIt ⁵¹ C4432

UMLS ⁷⁴ C0345832

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Summaries for Small Intestine Benign Neoplasm

MalaCards based summary : Small Intestine Benign Neoplasm, also known as neoplasm of the small intestine, is related to ileum cancer and small intestine cancer. An important gene associated with Small Intestine Benign Neoplasm is SST (Somatostatin), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Octreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and liver, and related phenotype is behavior/neurological.

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Related Diseases for Small Intestine Benign Neoplasm

Diseases related to Small Intestine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)

#	Related Disease	Score	Top Affiliating Genes
1	ileum cancer	30.4	ERBIN SST TOLLIP
2	small intestine cancer	11.6
3	small intestine leiomyoma	11.2
4	small intestine leiomyosarcoma	10.7
5	squamous cell carcinoma of the small intestine	10.7
6	duodenum cancer	10.3
7	meckel's diverticulum cancer	10.3
8	jejunal cancer	10.3
9	malignant glandular tumor of peripheral nerve sheath	10.1	SST SYP
10	pancreatic somatostatinoma	10.1	SST SYP
11	gastrointestinal neuroendocrine tumor	10.1	SST SYP
12	neuroendocrine tumor	10.1	SST SYP
13	pancreatic endocrine carcinoma	10.1	SST SYP
14	pancreatoblastoma	10.1	SST SYP
15	carcinoid tumors, intestinal	10.1	SST SYP
16	functional colonic disease	10.1	SST SYP
17	binswanger's disease	10.1	SST SYP
18	carcinoid syndrome	10.1	SST SYP
19	ectopic cushing syndrome	10.1	SST SYP
20	malignant pheochromocytoma	10.1	SST SYP
21	mixed ductal-endocrine carcinoma	10.1	SST SYP
22	colonic pseudo-obstruction	10.1	SST SYP
23	endocrine organ benign neoplasm	10.1	SST SYP
24	intestinal pseudo-obstruction	10.0	SST SYP
25	cell type benign neoplasm	10.0	SST SYP
26	merkel cell carcinoma	10.0	SST SYP
27	intestinal neuroendocrine benign tumor	10.0	BCAT1 MNX1
28	small intestine neuroendocrine neoplasm	10.0	BCAT1 MNX1
29	paraganglioma	10.0	SST SYP
30	intestinal benign neoplasm	10.0
31	multiple endocrine neoplasia, type i	9.9	SST SYP
32	small cell cancer of the lung	9.9	SST SYP
33	endocrine gland cancer	9.9	SST SYP
34	teratoma	9.8	MNX1 SYP
35	meningioma, familial	9.8	SST SYP

Graphical network of the top 20 diseases related to Small Intestine Benign Neoplasm:

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Symptoms & Phenotypes for Small Intestine Benign Neoplasm

MGI Mouse Phenotypes related to Small Intestine Benign Neoplasm:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.02	ERBIN GAN MNX1 SST SYP

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Drugs & Therapeutics for Small Intestine Benign Neoplasm

Drugs for Small Intestine Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Octreotide

Approved, Investigational

Phase 3

83150-76-9

6400441 383414

Synonyms:

(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide

10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa

10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide

10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide

79517-01-4 (acetate salt)

83150-76-9

AC1L1GVU

AC1L8LCD

AC1L9M4X

C07306

C5H12O2.C4H10

CHEBI:427278

CHEBI:611465

CHEMBL1680

CID383414

CID448601

CID54374

Compound 201 995

Compound 201995

Compound 201-995

D00442

D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide

D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide

D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide

DRG-0115

HMS2090C09

HS-2020

L000453

L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*

Longastatin

LS-177735

LS-187135

NCGC00181796-01

nchembio.184-comp3

NCI60_025753

Octreotida

Octreotida [Spanish]

Octreotide

Octreotide (USAN/INN)

Octreotide [USAN:INN:BAN]

Octreotide acetate

Octreotide acetate salt

Octreotide Acetate Salt

Octreotide-LAR

Octreotidum

Octreotidum [Latin]

Octrotide

SAN 201-995

Sandostatin

Sandostatine

Sandoz 201 995

Sandoz 201995

Sandoz 201-995

SM 201-995

SMS 201-995

SMS-201-995

UNII-RWM8CCW8GP

zacycloicosane-4-carboxamide acetate

2

Somatostatin

Approved, Investigational

Phase 3

38916-34-6, 51110-01-1

53481605

3

Antineoplastic Agents, Hormonal

Phase 3

4

Hormones

Phase 3

5

Gastrointestinal Agents

Phase 3

6

Hormone Antagonists

Phase 3

7

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3

8

Liver Extracts

Phase 1

9

Cola

Phase 1

10

Fluorodeoxyglucose F18

Interventional clinical trials:

(show all 12)

#	Name	Status	NCT ID	Phase	Drugs
1	Differences in Preparation for Small Bowel Capsule Endoscopy	Recruiting	NCT03351972	Phase 4	Klean Prep
2	A Study Comparing Treatment With 177Lu-DOTA0-Tyr3-Octreotate to Octreotide LAR in Patients With Inoperable, Progressive, Somatostatin Receptor Positive Midgut Carcinoid Tumours	Active, not recruiting	NCT01578239	Phase 3	Octreotide LAR;177Lu-DOTA0-Tyr3-Octreotate
3	Study of TCM Syndrome of Hepatocellular Carcinoma and Colorectal Cancer Based on System Science	Unknown status	NCT03189992	Phase 1	Bushen-Jianpi Dedoction;cinobufotalin injection
4	EnteroCT With Enteroclysis Versus Enterography-MRI for the Diagnosis of Tumors of the Small Intestine: a Pilot Study	Unknown status	NCT02872623	Not Applicable
5	IS There a Correlation Between Sypmtoms of Gastroparesis and the Duration of Video Caspule Retention in the Stomach	Unknown status	NCT01858220
6	Enteroscopy for Early Diagnosis of Tumors in Celiac Disease	Unknown status	NCT02325232	Not Applicable
7	European Novel Motorized Spiral Endoscopy Trial	Completed	NCT02965209	Not Applicable
8	Defining PET / CT Protocols With Optimized F18-FDG (Fluorodeoxyglucose) Dose, Focusing on Reduced Radiation Dose and Improved Image Quality	Completed	NCT02378337
9	Study of Small Bowel Tumor With Dual-phase Enhanced Computed Tomography (CTE) and Magnetic Resonance Enterography (MRE)	Recruiting	NCT03659357
10	Chromogranin A as Blood Marker in Cancer Patients	Recruiting	NCT03817866
11	PreOPerative Imaging of NeuroEndocrine Tumors	Active, not recruiting	NCT03958188
12	Phenotyping of Small Bowel Adenocarcinoma	Active, not recruiting	NCT02976090

Search NIH Clinical Center for Small Intestine Benign Neoplasm

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Genetic Tests for Small Intestine Benign Neoplasm

Genetic tests related to Small Intestine Benign Neoplasm:

#	Genetic test	Affiliating Genes
1	Neoplasm of the Small Intestine ³⁰

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Anatomical Context for Small Intestine Benign Neoplasm

MalaCards organs/tissues related to Small Intestine Benign Neoplasm:

⁴²

Small Intestine, Colon, Liver

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Publications for Small Intestine Benign Neoplasm

Articles related to Small Intestine Benign Neoplasm:

#	Title	Authors	Year
1	Three cases of small intestinal neoplasm. ( 13083804 )	RECHNITZER P	1953
2	Three cases of small-intestinal neoplasm with unusual clinical features. ( 13059482 )	RECHNITZER PA...BLAKE J	1953

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Genes for Small Intestine Benign Neoplasm

Genes related to Small Intestine Benign Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SST	Somatostatin	Protein Coding	15.14	DISEASES inferred ¹⁵
2	ERBIN	Erbb2 Interacting Protein	Protein Coding	15.02	DISEASES inferred ¹⁵
3	TOLLIP	Toll Interacting Protein	Protein Coding	14.76	DISEASES inferred ¹⁵
4	BCAT1	Branched Chain Amino Acid Transaminase 1	Protein Coding	14.71	DISEASES inferred ¹⁵
5	MNX1	Motor Neuron And Pancreas Homeobox 1	Protein Coding	14.66	DISEASES inferred ¹⁵
6	GAN	Gigaxonin	Protein Coding	14.61	DISEASES inferred ¹⁵
7	SYP	Synaptophysin	Protein Coding	14.58	DISEASES inferred ¹⁵

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Variations for Small Intestine Benign Neoplasm

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Expression for Small Intestine Benign Neoplasm

Search GEO for disease gene expression data for Small Intestine Benign Neoplasm.

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Pathways for Small Intestine Benign Neoplasm

Pathways related to Small Intestine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	10.52	MNX1 SYP

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GO Terms for Small Intestine Benign Neoplasm

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Sources for Small Intestine Benign Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

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⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

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⁵¹ NCIt

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⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

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⁶⁶ R&D Systems

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⁶⁹ SNOMED-CT

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⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

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⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia