MCID: SML039
MIFTS: 26

Small Intestine Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Small Intestine Benign Neoplasm

MalaCards integrated aliases for Small Intestine Benign Neoplasm:

Name: Small Intestine Benign Neoplasm 12 15
Neoplasm of the Small Intestine 30
Neoplasm of Small Intestine 12
Small Intestinal Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7505
NCIt 51 C4432
UMLS 74 C0345832

Summaries for Small Intestine Benign Neoplasm

MalaCards based summary : Small Intestine Benign Neoplasm, also known as neoplasm of the small intestine, is related to ileum cancer and small intestine cancer. An important gene associated with Small Intestine Benign Neoplasm is SST (Somatostatin), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Octreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and liver, and related phenotype is behavior/neurological.

Related Diseases for Small Intestine Benign Neoplasm

Diseases related to Small Intestine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 ileum cancer 30.4 ERBIN SST TOLLIP
2 small intestine cancer 11.6
3 small intestine leiomyoma 11.2
4 small intestine leiomyosarcoma 10.7
5 squamous cell carcinoma of the small intestine 10.7
6 duodenum cancer 10.3
7 meckel's diverticulum cancer 10.3
8 jejunal cancer 10.3
9 malignant glandular tumor of peripheral nerve sheath 10.1 SST SYP
10 pancreatic somatostatinoma 10.1 SST SYP
11 gastrointestinal neuroendocrine tumor 10.1 SST SYP
12 neuroendocrine tumor 10.1 SST SYP
13 pancreatic endocrine carcinoma 10.1 SST SYP
14 pancreatoblastoma 10.1 SST SYP
15 carcinoid tumors, intestinal 10.1 SST SYP
16 functional colonic disease 10.1 SST SYP
17 binswanger's disease 10.1 SST SYP
18 carcinoid syndrome 10.1 SST SYP
19 ectopic cushing syndrome 10.1 SST SYP
20 malignant pheochromocytoma 10.1 SST SYP
21 mixed ductal-endocrine carcinoma 10.1 SST SYP
22 colonic pseudo-obstruction 10.1 SST SYP
23 endocrine organ benign neoplasm 10.1 SST SYP
24 intestinal pseudo-obstruction 10.0 SST SYP
25 cell type benign neoplasm 10.0 SST SYP
26 merkel cell carcinoma 10.0 SST SYP
27 intestinal neuroendocrine benign tumor 10.0 BCAT1 MNX1
28 small intestine neuroendocrine neoplasm 10.0 BCAT1 MNX1
29 paraganglioma 10.0 SST SYP
30 intestinal benign neoplasm 10.0
31 multiple endocrine neoplasia, type i 9.9 SST SYP
32 small cell cancer of the lung 9.9 SST SYP
33 endocrine gland cancer 9.9 SST SYP
34 teratoma 9.8 MNX1 SYP
35 meningioma, familial 9.8 SST SYP

Graphical network of the top 20 diseases related to Small Intestine Benign Neoplasm:



Diseases related to Small Intestine Benign Neoplasm

Symptoms & Phenotypes for Small Intestine Benign Neoplasm

MGI Mouse Phenotypes related to Small Intestine Benign Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.02 ERBIN GAN MNX1 SST SYP

Drugs & Therapeutics for Small Intestine Benign Neoplasm

Drugs for Small Intestine Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 3 83150-76-9 6400441 383414
2
Somatostatin Approved, Investigational Phase 3 38916-34-6, 51110-01-1 53481605
3 Antineoplastic Agents, Hormonal Phase 3
4 Hormones Phase 3
5 Gastrointestinal Agents Phase 3
6 Hormone Antagonists Phase 3
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
8 Liver Extracts Phase 1
9 Cola Phase 1
10 Fluorodeoxyglucose F18

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Differences in Preparation for Small Bowel Capsule Endoscopy Recruiting NCT03351972 Phase 4 Klean Prep
2 A Study Comparing Treatment With 177Lu-DOTA0-Tyr3-Octreotate to Octreotide LAR in Patients With Inoperable, Progressive, Somatostatin Receptor Positive Midgut Carcinoid Tumours Active, not recruiting NCT01578239 Phase 3 Octreotide LAR;177Lu-DOTA0-Tyr3-Octreotate
3 Study of TCM Syndrome of Hepatocellular Carcinoma and Colorectal Cancer Based on System Science Unknown status NCT03189992 Phase 1 Bushen-Jianpi Dedoction;cinobufotalin injection
4 EnteroCT With Enteroclysis Versus Enterography-MRI for the Diagnosis of Tumors of the Small Intestine: a Pilot Study Unknown status NCT02872623 Not Applicable
5 IS There a Correlation Between Sypmtoms of Gastroparesis and the Duration of Video Caspule Retention in the Stomach Unknown status NCT01858220
6 Enteroscopy for Early Diagnosis of Tumors in Celiac Disease Unknown status NCT02325232 Not Applicable
7 European Novel Motorized Spiral Endoscopy Trial Completed NCT02965209 Not Applicable
8 Defining PET / CT Protocols With Optimized F18-FDG (Fluorodeoxyglucose) Dose, Focusing on Reduced Radiation Dose and Improved Image Quality Completed NCT02378337
9 Study of Small Bowel Tumor With Dual-phase Enhanced Computed Tomography (CTE) and Magnetic Resonance Enterography (MRE) Recruiting NCT03659357
10 Chromogranin A as Blood Marker in Cancer Patients Recruiting NCT03817866
11 PreOPerative Imaging of NeuroEndocrine Tumors Active, not recruiting NCT03958188
12 Phenotyping of Small Bowel Adenocarcinoma Active, not recruiting NCT02976090

Search NIH Clinical Center for Small Intestine Benign Neoplasm

Genetic Tests for Small Intestine Benign Neoplasm

Genetic tests related to Small Intestine Benign Neoplasm:

# Genetic test Affiliating Genes
1 Neoplasm of the Small Intestine 30

Anatomical Context for Small Intestine Benign Neoplasm

MalaCards organs/tissues related to Small Intestine Benign Neoplasm:

42
Small Intestine, Colon, Liver

Publications for Small Intestine Benign Neoplasm

Articles related to Small Intestine Benign Neoplasm:

# Title Authors Year
1
Three cases of small intestinal neoplasm. ( 13083804 )
1953
2
Three cases of small-intestinal neoplasm with unusual clinical features. ( 13059482 )
1953

Variations for Small Intestine Benign Neoplasm

Expression for Small Intestine Benign Neoplasm

Search GEO for disease gene expression data for Small Intestine Benign Neoplasm.

Pathways for Small Intestine Benign Neoplasm

Pathways related to Small Intestine Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 MNX1 SYP

GO Terms for Small Intestine Benign Neoplasm

Sources for Small Intestine Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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