Small Intestine Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Small Intestine Benign Neoplasm

MalaCards integrated aliases for Small Intestine Benign Neoplasm:

Name: Small Intestine Benign Neoplasm ¹² ¹⁵

Neoplasm of the Small Intestine ²⁹

Neoplasm of Small Intestine ¹²

Small Intestinal Neoplasm ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7505

NCIt ⁵⁰ C4432

SNOMED-CT ⁶⁷ 126832004

UMLS ⁷⁰ C0345832

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Summaries for Small Intestine Benign Neoplasm

MalaCards based summary : Small Intestine Benign Neoplasm, also known as neoplasm of the small intestine, is related to small intestine leiomyoma and small intestine leiomyosarcoma. An important gene associated with Small Intestine Benign Neoplasm is HOOK3 (Hook Microtubule Tethering Protein 3), and among its related pathways/superpathways is C-MYB transcription factor network. Affiliated tissues include small intestine, and related phenotypes are growth/size/body region and nervous system

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Related Diseases for Small Intestine Benign Neoplasm

Diseases related to Small Intestine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 322)

#	Related Disease	Score	Top Affiliating Genes
1	small intestine leiomyoma	31.9	KIT CD34 ANO1
2	small intestine leiomyosarcoma	31.0	KIT CD34 ANO1
3	small intestine neuroendocrine neoplasm	30.6	SST PNMA2 NONO MLF1 MIR3137 MEN1
4	rare tumor	30.6	SST KIT
5	neurilemmoma	29.5	KIT ENO2 CD34 ANO1
6	small intestine cancer	11.3
7	squamous cell carcinoma of the small intestine	10.6
8	type c thymoma	10.4	SST KIT
9	ectopic cushing syndrome	10.4	SST CHGA
10	rectum neuroendocrine neoplasm	10.4	SYP SST
11	glucagonoma	10.4	SST CHGA
12	primary hepatic neuroendocrine carcinoma	10.4	SYP CHGA
13	esophageal neuroendocrine tumor	10.4	SYP CHGA
14	acinar cell cystadenocarcinoma	10.3	SYP CHGA
15	vulvar eccrine porocarcinoma	10.3	SYP CHGA
16	pancreatic serous cystadenocarcinoma	10.3	SYP CHGA
17	vaginal tubulovillous adenoma	10.3	SYP CHGA
18	mixed ductal-endocrine carcinoma	10.3	SYP CHGA
19	papillary thymic adenocarcinoma	10.3	SYP CHGA
20	breast papillary carcinoma	10.3	SYP CHGA
21	appendix adenocarcinoma	10.3	SYP CHGA
22	gastric leiomyoma	10.3	KIT ANO1
23	gastric leiomyosarcoma	10.3	KIT ANO1
24	small intestinal sarcoma	10.3	KIT ANO1
25	pulmonary large cell neuroendocrine carcinoma	10.3	SYP CHGA
26	vaginal adenoma	10.3	SYP CHGA
27	duodenal somatostatinoma	10.3	SST MEN1
28	vaginal benign neoplasm	10.3	SYP CHGA
29	pituitary infarct	10.3	SST MEN1
30	mucinous stomach adenocarcinoma	10.3	KIT ANO1
31	chordoid meningioma	10.3	SYP CHGA
32	pancreatic acinar cell adenocarcinoma	10.3	SYP CHGA
33	extra-adrenal pheochromocytoma	10.3	SYP CHGA
34	papillary ependymoma	10.3	SYP MEN1
35	familial isolated pituitary adenoma	10.3	MEN1 CDKN1B
36	peritoneal serous adenocarcinoma	10.3	SYP CHGA
37	tanycytic ependymoma	10.3	SYP MEN1
38	spinal cord sarcoma	10.3	KIT CD34
39	laryngeal neuroendocrine tumor	10.3	SYP SST CHGA
40	glomangioma	10.2	SYP CD34
41	hormone producing pituitary cancer	10.2	SST MEN1
42	gallbladder leiomyoma	10.2	KIT CD34
43	binswanger's disease	10.2	SYP SST CHGA
44	adrenal medulla cancer	10.2	SYP SST CHGA
45	laryngeal small cell carcinoma	10.2	SYP KIT CHGA
46	pancreatoblastoma	10.2	SYP SST CHGA
47	mucocele of appendix	10.2	KIT CD34
48	pulmonary blastoma	10.2	SYP SST CHGA
49	gallbladder leiomyosarcoma	10.2	KIT CD34
50	benign fibrous mesothelioma	10.2	KIT CD34

Graphical network of the top 20 diseases related to Small Intestine Benign Neoplasm:

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Symptoms & Phenotypes for Small Intestine Benign Neoplasm

MGI Mouse Phenotypes related to Small Intestine Benign Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.7	ANO1 APC CDKN1B CHGA ENO2 HOOK3
2	nervous system	MP:0003631	9.32	ANO1 APC CDKN1B CHGA ENO2 IPMK

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Drugs & Therapeutics for Small Intestine Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Small Intestine Benign Neoplasm

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Genetic Tests for Small Intestine Benign Neoplasm

Genetic tests related to Small Intestine Benign Neoplasm:

#	Genetic test	Affiliating Genes
1	Neoplasm of the Small Intestine ²⁹

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Anatomical Context for Small Intestine Benign Neoplasm

MalaCards organs/tissues related to Small Intestine Benign Neoplasm:

⁴⁰

Small Intestine

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Publications for Small Intestine Benign Neoplasm

Articles related to Small Intestine Benign Neoplasm:

#	Title	Authors	PMID	Year
1	[Clinical analysis of primary small intestinal neoplasms in 305 cases]. ⁶¹	Yang WL...Wang YJ	18396694	2007
2	[A case of primary jejunal adenocarcinoma diagnosed by enteroscopy using pediatric colonoscope]. ⁶¹	Lee CH...Jeon YS	17132927	2006
3	Usefulness of MR imaging for diseases of the small intestine: comparison with CT. ⁶¹	Kim JH...Auh YH	11752928	2000
4	Imaging of primary small intestinal tumours by enteroclysis and CT with pathological correlation. ⁶¹	Gourtsoyiannis N...Mako E	9166558	1997
5	A case of extragenital choriocarcinoma in the jejunum. ⁶¹	Harada N...Nawata H	1858745	1991
6	Tumors of the small intestine. ⁶¹	Ashley SW...Wells SA	3285475	1988
7	Three cases of small-intestinal neoplasm with unusual clinical features. ⁶¹	RECHNITZER PA...BLAKE J	13059482	1953
8	Three cases of small intestinal neoplasm. ⁶¹	RECHNITZER P	13083804	1953

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Genes for Small Intestine Benign Neoplasm

Genes related to Small Intestine Benign Neoplasm (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HOOK3	Hook Microtubule Tethering Protein 3	Protein Coding	6.74	DISEASES inferred ¹⁵
2	SST	Somatostatin	Protein Coding	6.4	DISEASES inferred ¹⁵
3	MIR3137	MicroRNA 3137	RNA Gene	6.07	DISEASES inferred ¹⁵
4	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	6.01	DISEASES inferred ¹⁵
5	CHGA	Chromogranin A	Protein Coding	5.96	DISEASES inferred ¹⁵
6	MLF1	Myeloid Leukemia Factor 1	Protein Coding	5.95	DISEASES inferred ¹⁵
7	SYP	Synaptophysin	Protein Coding	5.78	DISEASES inferred ¹⁵
8	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	5.78	DISEASES inferred ¹⁵
9	ANO1	Anoctamin 1	Protein Coding	5.67	DISEASES inferred ¹⁵
10	MEN1	Menin 1	Protein Coding	5.67	DISEASES inferred ¹⁵
11	NONO	Non-POU Domain Containing Octamer Binding	Protein Coding	5.67	DISEASES inferred ¹⁵
12	PNMA2	PNMA Family Member 2	Protein Coding	5.38	DISEASES inferred ¹⁵
13	IPMK	Inositol Polyphosphate Multikinase	Protein Coding	5.38	DISEASES inferred ¹⁵
14	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	5.36	DISEASES inferred ¹⁵
15	ENO2	Enolase 2	Protein Coding	5.34	DISEASES inferred ¹⁵
16	CD34	CD34 Molecule	Protein Coding	5.32	DISEASES inferred ¹⁵

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Variations for Small Intestine Benign Neoplasm

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Expression for Small Intestine Benign Neoplasm

Search GEO for disease gene expression data for Small Intestine Benign Neoplasm.

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Pathways for Small Intestine Benign Neoplasm

Pathways related to Small Intestine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	C-MYB transcription factor network ¹	10.69	KIT CDKN1B CD34

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GO Terms for Small Intestine Benign Neoplasm

Biological processes related to Small Intestine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell cycle arrest	GO:0007050	9.58	MLF1 CDKN1B APC
2	mast cell degranulation	GO:0043303	9.37	KIT CHGA
3	positive regulation of pseudopodium assembly	GO:0031274	9.32	KIT APC
4	myeloid progenitor cell differentiation	GO:0002318	9.26	MLF1 KIT
5	mast cell chemotaxis	GO:0002551	9.16	KIT CHGA
6	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO:0045736	9.13	MEN1 CDKN1B APC
7	mast cell cytokine production	GO:0032762	8.62	KIT CHGA

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Sources for Small Intestine Benign Neoplasm

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