MCID: SML039
MIFTS: 28

Small Intestine Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Small Intestine Benign Neoplasm

MalaCards integrated aliases for Small Intestine Benign Neoplasm:

Name: Small Intestine Benign Neoplasm 12 15
Neoplasm of the Small Intestine 29
Neoplasm of Small Intestine 12
Small Intestinal Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7505
NCIt 49 C4432
SNOMED-CT 67 126832004
UMLS 71 C0345832

Summaries for Small Intestine Benign Neoplasm

MalaCards based summary : Small Intestine Benign Neoplasm, also known as neoplasm of the small intestine, is related to small intestine leiomyoma and small intestine leiomyosarcoma. An important gene associated with Small Intestine Benign Neoplasm is SPINK5 (Serine Peptidase Inhibitor Kazal Type 5), and among its related pathways/superpathways is Neuroscience. The drugs Linaclotide and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include small intestine, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Small Intestine Benign Neoplasm

Diseases related to Small Intestine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)
# Related Disease Score Top Affiliating Genes
1 small intestine leiomyoma 32.5 KIT ANO1
2 small intestine leiomyosarcoma 31.8 KIT ANO1
3 duodenum cancer 31.1 SST SPINK5 MEN1
4 rare tumor 30.4 SST KIT
5 intestinal obstruction 30.1 SST KIT ANO1
6 neurilemmoma 29.8 KIT ENO2 ANO1
7 carcinoid syndrome 29.5 SYP SST MEN1 ENO2 CHGA
8 adenoma 29.3 SYP SST MEN1 CHGA APC
9 hemangioma 29.2 SYP MEN1 KIT ENO2 CHGA
10 small intestine neuroendocrine neoplasm 28.8 SSTR1 SST SPINK5 NONO MLF1 MIR3137
11 small intestine cancer 11.8
12 squamous cell carcinoma of the small intestine 10.8
13 appendiceal neoplasm 10.5 SPINK5 CHGA
14 tricuspid valve stenosis 10.5 SST SPINK5
15 primary hepatic neuroendocrine carcinoma 10.5 SYP CHGA
16 acinar cell cystadenocarcinoma 10.5 SYP CHGA
17 rectum neuroendocrine neoplasm 10.5 SYP SST
18 vulvar eccrine porocarcinoma 10.5 SYP CHGA
19 cervical large cell neuroendocrine carcinoma 10.5 SYP CHGA
20 glucagonoma 10.5 SST CHGA
21 mixed ductal-endocrine carcinoma 10.4 SYP CHGA
22 pancreatic serous cystadenocarcinoma 10.4 SYP CHGA
23 type c thymoma 10.4 SST KIT
24 meckel's diverticulum cancer 10.4
25 ileum cancer 10.4
26 jejunal cancer 10.4
27 vaginal tubulovillous adenoma 10.4 SYP CHGA
28 papillary thymic adenocarcinoma 10.4 SYP CHGA
29 breast papillary carcinoma 10.4 SYP CHGA
30 laryngeal neuroendocrine tumor 10.4 SYP CHGA
31 appendix adenocarcinoma 10.4 SYP CHGA
32 benign perivascular tumor 10.4 SYP KIT
33 deep leiomyoma 10.4 KIT ANO1
34 gastric liposarcoma 10.4 KIT ANO1
35 ectopic cushing syndrome 10.4 SYP SST
36 pulmonary large cell neuroendocrine carcinoma 10.4 SYP CHGA
37 vaginal adenoma 10.4 SYP CHGA
38 gastric leiomyoma 10.4 KIT ANO1
39 liver leiomyoma 10.4 KIT ANO1
40 gastric leiomyosarcoma 10.4 KIT ANO1
41 colon leiomyosarcoma 10.4 KIT ANO1
42 pancreatic acinar cell adenocarcinoma 10.4 SYP CHGA
43 familial isolated pituitary adenoma 10.4 MEN1 CDKN1B
44 pituitary infarct 10.4 SST MEN1
45 vaginal benign neoplasm 10.4 SYP CHGA
46 extra-adrenal pheochromocytoma 10.3 SYP CHGA
47 retroperitoneal leiomyosarcoma 10.3 KIT ANO1
48 chordoid meningioma 10.3 SYP CHGA
49 esophageal neuroendocrine tumor 10.3 SYP SPINK5 CHGA
50 cecal disease 10.3 SYP SPINK5 CHGA

Graphical network of the top 20 diseases related to Small Intestine Benign Neoplasm:



Diseases related to Small Intestine Benign Neoplasm

Symptoms & Phenotypes for Small Intestine Benign Neoplasm

MGI Mouse Phenotypes related to Small Intestine Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.65 ANO1 APC CDKN1B ENO2 HOOK3 KIT
2 nervous system MP:0003631 9.36 ANO1 APC CDKN1B CHGA ENO2 IPMK

Drugs & Therapeutics for Small Intestine Benign Neoplasm

Drugs for Small Intestine Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Linaclotide Approved Phase 4 851199-59-2 65351
2 Gastrointestinal Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single-dose Linaclotide for Capsule Endoscopy Preparation Completed NCT02465385 Phase 4 Linaclotide

Search NIH Clinical Center for Small Intestine Benign Neoplasm

Genetic Tests for Small Intestine Benign Neoplasm

Genetic tests related to Small Intestine Benign Neoplasm:

# Genetic test Affiliating Genes
1 Neoplasm of the Small Intestine 29

Anatomical Context for Small Intestine Benign Neoplasm

MalaCards organs/tissues related to Small Intestine Benign Neoplasm:

40
Small Intestine

Publications for Small Intestine Benign Neoplasm

Articles related to Small Intestine Benign Neoplasm:

# Title Authors PMID Year
1
[Clinical analysis of primary small intestinal neoplasms in 305 cases]. 61
18396694 2007
2
[A case of primary jejunal adenocarcinoma diagnosed by enteroscopy using pediatric colonoscope]. 61
17132927 2006
3
Usefulness of MR imaging for diseases of the small intestine: comparison with CT. 61
11752928 2000
4
Imaging of primary small intestinal tumours by enteroclysis and CT with pathological correlation. 61
9166558 1997
5
A case of extragenital choriocarcinoma in the jejunum. 61
1858745 1991
6
Tumors of the small intestine. 61
3285475 1988
7
Three cases of small-intestinal neoplasm with unusual clinical features. 61
13059482 1953
8
Three cases of small intestinal neoplasm. 61
13083804 1953

Variations for Small Intestine Benign Neoplasm

Expression for Small Intestine Benign Neoplasm

Search GEO for disease gene expression data for Small Intestine Benign Neoplasm.

Pathways for Small Intestine Benign Neoplasm

Pathways related to Small Intestine Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 SYP SSTR1 ENO2 ANO1

GO Terms for Small Intestine Benign Neoplasm

Biological processes related to Small Intestine Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.72 SSTR1 SST MEN1 CDKN1B APC
2 cell cycle arrest GO:0007050 9.61 MLF1 CDKN1B APC
3 mast cell degranulation GO:0043303 9.4 KIT CHGA
4 positive regulation of pseudopodium assembly GO:0031274 9.37 KIT APC
5 myeloid progenitor cell differentiation GO:0002318 9.26 MLF1 KIT
6 mast cell chemotaxis GO:0002551 9.16 KIT CHGA
7 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.13 MEN1 CDKN1B APC
8 mast cell cytokine production GO:0032762 8.62 KIT CHGA

Sources for Small Intestine Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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