MCID: SML016
MIFTS: 53

Small Intestine Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Small Intestine Cancer

MalaCards integrated aliases for Small Intestine Cancer:

Name: Small Intestine Cancer 12 53 15
Small Intestine Carcinoma 12 15 73
Neoplasm of Small Intestine 12 73
Small Intestine Neoplasm 12 15
Malignant Neoplasms of the Small Intestine 53
Malignant Tumor of Small Intestine 73
Neoplasm of the Small Intestine 29
Small Intestinal Carcinoma 12
Cancer of the Small Bowel 12
Small Intestinal Neoplasm 12
Small Bowel Cancer 12
Small Bowel Tumors 53

Classifications:



External Ids:

Disease Ontology 12 DOID:10154 DOID:4907 DOID:7505
ICD10 33 C17 C17.9
ICD9CM 35 152.9
SNOMED-CT 68 94048009

Summaries for Small Intestine Cancer

Disease Ontology : 12 A small intestine cancer that develops from epithelial cells and is located in the small intestine.

MalaCards based summary : Small Intestine Cancer, also known as small intestine carcinoma, is related to small intestine adenocarcinoma and gallbladder cancer. An important gene associated with Small Intestine Cancer is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are TCR Signaling (Qiagen) and Endometrial cancer. The drugs Oxaliplatin and Cola have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Synthetic lethal with vaccinia virus (VACV) infection

Wikipedia : 76 In oncology, small intestine cancer, also small bowel cancer and cancer of the small bowel, is a cancer... more...

Related Diseases for Small Intestine Cancer

Diseases in the Small Intestine Cancer family:

Large Intestine Cancer Intestine Carcinoma in Situ

Diseases related to Small Intestine Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 small intestine adenocarcinoma 31.9 MLH1 MUC2 MUC6
2 gallbladder cancer 31.5 KRAS MLH1 MUC2
3 duodenum cancer 30.2 SST MUC6 MUC2 MEN1 KRT7 KRAS
4 mismatch repair cancer syndrome 29.7 MLH1 MSH2 MSH6 PMS2
5 lynch syndrome 29.1 PMS2 MUC2 MSH6 MSH2 MLH1 KRAS
6 duodenum adenocarcinoma 29.1 MUC6 MUC2 KRT7 KRAS CDX2
7 intestinal benign neoplasm 29.0 MUC2 MSH2 MLH1 KRAS HRAS CDX2
8 colorectal cancer 27.9 PMS2 MUC6 MUC2 MSH6 MSH2 MLH1
9 small intestine cancer, childhood 12.2
10 small intestine carcinoid neuroendocrine tumor 11.0
11 ileum cancer 11.0
12 squamous cell carcinoma of the small intestine 10.6
13 endocervical carcinoma 10.3 KRT7 MUC6
14 monophasic synovial sarcoma 10.3 KRT7 MLH1
15 chondroid lipoma 10.3 KRT7 MEN1
16 anal fistula 10.3 MLH1 MSH2
17 gastric leiomyoma 10.3 MLH1 MSH6
18 bladder lymphoma 10.3 KRT20 KRT7
19 vulval paget's disease 10.3 KRT20 KRT7
20 papillary serous adenocarcinoma 10.3 KRT20 KRT7
21 medulloepithelioma 10.3 KRT20 KRT7
22 small intestine leiomyosarcoma 10.3
23 renal pelvis carcinoma 10.3 KRT20 KRT7
24 glycogen-rich clear cell breast carcinoma 10.3 KRT20 KRT7
25 bile duct adenoma 10.3 KRT20 KRT7
26 adenoid squamous cell carcinoma 10.3 KRT20 KRT7
27 intratubular embryonal carcinoma 10.3 KRT20 KRT7
28 meibomian cyst 10.3 KRT20 KRT7
29 small cell carcinoma of the bladder 10.3 KRT20 KRT7
30 attenuated familial adenomatous polyposis 10.3 MSH2 MSH6
31 meckel's diverticulum cancer 10.3
32 jejunal cancer 10.3
33 chronic ethmoiditis 10.3 MUC2 MUC6
34 bile duct mucoepidermoid carcinoma 10.3 KRT7 MUC2
35 clear cell adenoma 10.2 MEN1 MUC2
36 carcinoid tumors, intestinal 10.2 MEN1 SST
37 hormone producing pituitary cancer 10.2 MEN1 SST
38 colorectal cancer, hereditary nonpolyposis, type 7 10.2 MLH1 MSH2
39 cystic basal cell carcinoma 10.2 KRT20 KRT7
40 prostate squamous cell carcinoma 10.2 HRAS KRT7
41 solid adenocarcinoma with mucin production 10.2 KRT7 MUC6
42 spindle cell intraocular melanoma 10.2 MLH1 PMS2
43 seminal vesicle adenocarcinoma 10.2 KRT20 KRT7
44 transverse colon cancer 10.2 KRT20 KRT7
45 malignant syringoma 10.2 KRT20 KRT7
46 colorectal cancer 5 10.2 MLH1 MSH6
47 adenomyoma 10.2 KRT7 MLH1 MUC6
48 papillary transitional carcinoma 10.2 KRT20 KRT7
49 polyposis syndrome, hereditary mixed, 1 10.2 MLH1 MUC6
50 thymic neuroendocrine tumor 10.2 HRAS MEN1

Comorbidity relations with Small Intestine Cancer via Phenotypic Disease Network (PDN):


Colorectal Cancer Deficiency Anemia
Intestinal Obstruction

Graphical network of the top 20 diseases related to Small Intestine Cancer:



Diseases related to Small Intestine Cancer

Symptoms & Phenotypes for Small Intestine Cancer

GenomeRNAi Phenotypes related to Small Intestine Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.35 MEN1 MLH1 MSH2 MSH6 PMS2
2 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 CDX2 KRAS MLH1 MSH6 PMS2

MGI Mouse Phenotypes related to Small Intestine Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 CDX2 KRAS KRT7 MEN1 MLH1 MSH2
2 digestive/alimentary MP:0005381 9.91 CDX2 HRAS KRAS MEN1 MLH1 MSH2
3 homeostasis/metabolism MP:0005376 9.9 CDX2 HRAS KRAS KRT7 MEN1 MLH1
4 mortality/aging MP:0010768 9.65 CDX2 HRAS KRAS MEN1 MLH1 MSH2
5 neoplasm MP:0002006 9.28 CDX2 HRAS KRAS MEN1 MLH1 MSH2

Drugs & Therapeutics for Small Intestine Cancer

Drugs for Small Intestine Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 218)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 4,Phase 2,Phase 1 61825-94-3 43805 6857599 5310940 9887054
2 Cola Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
3 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
4 Orange Approved Phase 3
5
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
6
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
7
Ondansetron Approved Phase 3 99614-02-5 4595
8
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
9
Ofloxacin Approved Phase 3 82419-36-1 4583
10
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
11
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
12
Morphine Approved, Investigational Phase 3 57-27-2 5288826
13
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
14
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
15
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2 1177-87-3
16 Pancreatic Polypeptide Investigational Phase 3,Phase 2,Phase 1 59763-91-6
17 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
18 Clavulanic Acids Phase 3
19 Cytochrome P-450 Enzyme Inhibitors Phase 3
20 beta-Lactamase Inhibitors Phase 3
21 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
22 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
23 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
24 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable
25 Antitubercular Agents Phase 3
26 Amoxicillin-Potassium Clavulanate Combination Phase 3
27 Dermatologic Agents Phase 3,Phase 2,Phase 1,Not Applicable
28 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
29 Hormone Antagonists Phase 3,Phase 2,Phase 1
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
31 glucocorticoids Phase 3,Phase 2,Phase 1
32 Hormones Phase 3,Phase 2,Phase 1
33 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Phase 1
34 Antirheumatic Agents Phase 2, Phase 3,Phase 1
35 Autonomic Agents Phase 3,Phase 1
36 Central Nervous System Depressants Phase 3,Phase 1
37 Antiemetics Phase 3,Phase 1
38 Antipsychotic Agents Phase 3
39 Serotonin Antagonists Phase 3,Phase 2
40 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
41 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
42 Psychotropic Drugs Phase 3
43 Anti-Anxiety Agents Phase 3
44 Serotonin Agents Phase 3,Phase 2
45 Tranquilizing Agents Phase 3
46 Neurotransmitter Agents Phase 3,Phase 2,Phase 1
47 Antipruritics Phase 3
48 Hematinics Phase 3
49 Epoetin alfa Phase 3 113427-24-0
50 Anti-Infective Agents, Urinary Phase 3

Interventional clinical trials:

(show top 50) (show all 119)
# Name Status NCT ID Phase Drugs
1 Relationship Between Platinum Levels in the Blood and Neurotoxicity in Patients Who Are Receiving Oxaliplatin for Gastrointestinal Cancer Unknown status NCT00274885 Phase 4 oxaliplatin
2 Differences in Preparation for Small Bowel Capsule Endoscopy Recruiting NCT03351972 Phase 4 Klean Prep
3 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
4 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
5 Epoetin Alfa in Treating Anemia in Patients Who Are Receiving Chemotherapy Completed NCT00003600 Phase 3
6 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
7 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
8 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
9 Ondansetron With or Without Dexamethasone to Prevent Vomiting in Patients Receiving Radiation Therapy to the Upper Abdomen Completed NCT00016380 Phase 3 dexamethasone;ondansetron
10 Exisulind in Preventing Polyps in Patients With Familial Adenomatous Polyposis Withdrawn NCT00026468 Phase 2, Phase 3 exisulind
11 High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Intestinal T-Cell Lymphoma Unknown status NCT00669812 Phase 2 carmustine;cyclophosphamide;cytarabine;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;melphalan;methotrexate;prednisolone;vincristine sulfate
12 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
13 Irinotecan, Oxaliplatin, and Capecitabine as First-Line Therapy in Treating Patients With Metastatic or Unresectable Locally Advanced Small Bowel Cancer Completed NCT00433550 Phase 2 capecitabine;irinotecan hydrochloride;oxaliplatin
14 Interferon Alfa-2b in Treating Patients With Advanced Low-Grade Non-Hodgkin's Lymphoma Completed NCT00006039 Phase 2
15 Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone With or Without Gemcitabine in Treating Patients With Previously Untreated Aggressive Non-Hodgkin's Lymphoma Completed NCT00079261 Phase 2 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;gemcitabine hydrochloride;prednisone;vincristine sulfate
16 Gemcitabine, Docetaxel, and Filgrastim in Treating Patients With Recurrent or Persistent Leiomyosarcoma or Soft Tissue Sarcoma Completed NCT00004066 Phase 2 docetaxel;gemcitabine hydrochloride
17 Nitrocamptothecin in Treating Patients With Soft Tissue Sarcomas Completed NCT00005874 Phase 2 rubitecan
18 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
19 Abraxane in CIMP-High Colorectal and Small Bowel Adenocarcinomas Completed NCT01730586 Phase 2 Abraxane
20 CAPOX in KRAS Wild-Type Advanced Adenocarcinoma of the Small Bowel or Ampulla of Vater Completed NCT01202409 Phase 2 Panitumumab
21 Combination Chemotherapy Plus Interferon Alfa Followed by Filgrastim in Treating Patients With Gastrointestinal Tract Cancer Completed NCT00019474 Phase 2 fluorouracil;hydroxyurea
22 Endoscopic Placement of Metal Stent in Patients With Cancer-Related Bowel Obstruction Completed NCT00004911 Phase 1, Phase 2
23 Endoscopic Placement of Metal Stents in Treating Patients With Cancer- Related Duodenal Obstruction Completed NCT00004910 Phase 1, Phase 2
24 Octreotide as Palliative Therapy for Cancer-Related Bowel Obstruction That Cannot Be Removed by Surgery Completed NCT00004895 Phase 2 octreotide acetate
25 Combination Chemotherapy in Treating Patients With Stage III Ovarian Epithelial Cancer or Gastrointestinal Cancer Completed NCT00005049 Phase 2 carboplatin;cisplatin;floxuridine
26 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
27 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
28 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
29 Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant For Hematological Cancer Completed NCT00589563 Phase 2 cyclophosphamide;etoposide;fludarabine phosphate;melphalan;methotrexate;sirolimus;tacrolimus
30 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00005804 Phase 2 cyclophosphamide
31 Non-Ablative Allo HSCT For Hematologic Malignancies or SAA Completed NCT00006379 Phase 2 cyclophosphamide;fludarabine phosphate
32 Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer Completed NCT00096083 Phase 2 isolated perfusion;melphalan
33 Capecitabine and Oxaliplatin in Adenocarcinoma of the Small Bowel and Ampulla of Vater Completed NCT00354887 Phase 2 Capecitabine;Oxaliplatin
34 NB1011 Administered by Continuous Infusion in Cancers That Overexpress Thymidylate Synthase (TS) Completed NCT00248404 Phase 1, Phase 2 NB1011
35 Clofarabine in Treating Patients With T-Cell or Natural Killer-Cell Non-Hodgkin's Lymphoma That Has Relapsed or Not Responded to Previous Treatment Active, not recruiting NCT00416351 Phase 1, Phase 2 clofarabine
36 Pembrolizumab in Treating Patients With Small Bowel Adenocarcinoma That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery Active, not recruiting NCT02949219 Phase 2
37 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
38 Antineoplaston Therapy in Treating Patients With Cancer of the Small Intestine Terminated NCT00003522 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
39 Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy in Patients With Primary Abdominal Cancer Terminated NCT00903396 Phase 2 palonosetron hydrochloride
40 Vaccine Therapy in Treating Patients With Cancer of the Gastrointestinal Tract Terminated NCT00012246 Phase 2
41 Effects of S-1 and Capecitabine on Coronary Artery Blood Flow Terminated NCT02216149 Phase 2 S-1;Capecitabine;Oxaliplatin
42 Vaccine Therapy and GM-CSF in Treating Patients With CNS Lymphoma Withdrawn NCT00621036 Phase 2 methotrexate;thiotepa
43 Alemtuzumab and Combination Chemotherapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IV Peripheral T-Cell Lymphoma Unknown status NCT00562068 Phase 1 cyclophosphamide;doxorubicin hydrochloride;prednisolone;vincristine sulfate
44 Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions Unknown status NCT00066404 Phase 1
45 Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer Completed NCT00019773 Phase 1 capecitabine;oxaliplatin
46 Vorinostat After Stem Cell Transplant in Treating Patients With High-Risk Lymphoma Completed NCT00561418 Phase 1 vorinostat
47 Monoclonal Antibody Therapy in Treating Patients With Advanced or Recurrent Lymphoma Completed NCT00006009 Phase 1
48 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in Treating Patients With an Advanced Solid Tumor or Lymphoma Completed NCT00088868 Phase 1 alvespimycin hydrochloride
49 Combination Chemotherapy With or Without Biological Therapy in Treating Patients With Refractory Solid Tumor or Lymphoma Completed NCT00005021 Phase 1 carboplatin;paclitaxel;topotecan hydrochloride
50 PS-341 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00004002 Phase 1 bortezomib

Search NIH Clinical Center for Small Intestine Cancer

Genetic Tests for Small Intestine Cancer

Genetic tests related to Small Intestine Cancer:

# Genetic test Affiliating Genes
1 Neoplasm of the Small Intestine 29

Anatomical Context for Small Intestine Cancer

MalaCards organs/tissues related to Small Intestine Cancer:

41
Small Intestine, Liver, Colon, T Cells, Lung, Ovary, Pancreas

The Foundational Model of Anatomy Ontology organs/tissues related to Small Intestine Cancer:

19
The Small Intestine

Publications for Small Intestine Cancer

Articles related to Small Intestine Cancer:

(show all 11)
# Title Authors Year
1
Adiposity and risks of colorectal and small intestine cancer in Chinese adults: a prospective study of 0.5 million people. ( 29872150 )
2018
2
Incidentally Detected Small Intestine Intussusception Caused by Primary Small Intestine Carcinoma on (18)F-FDG PET/CT. ( 28878855 )
2017
3
Hemorrhagic small intestine cancer with solitary pulmonary metastasis initially presented as suspected primary lung cancer: an autopsy report. ( 18432067 )
2007
4
Associations between small intestine cancer and other primary cancers: an international population-based study. ( 16003748 )
2006
5
Small Intestine Cancer Treatment (PDQAr): Patient Version ( 26389461 )
2002
6
Small Intestine Cancer Treatment (PDQAr): Health Professional Version ( 26889555 )
2002
7
Small Intestine Cancer Treatment (PDQAr): Health Professional Version ( 26389423 )
2002
8
Small Intestine Cancer Treatment (PDQAr): Patient Version ( 27390834 )
2002
9
Iron deficiency anemia as the sole symptom of small intestine carcinoma. ( 11386025 )
2001
10
Risk factors for small intestine cancer. ( 8481495 )
1993
11
Small intestine carcinoma in the Peutz-Jeghers syndrome. ( 2634217 )
1989

Variations for Small Intestine Cancer

Expression for Small Intestine Cancer

Search GEO for disease gene expression data for Small Intestine Cancer.

Pathways for Small Intestine Cancer

Pathways related to Small Intestine Cancer according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 HRAS KRAS MLH1 MSH2 MSH6
2
Show member pathways
12.58 HRAS KRAS MLH1 MSH2 MSH6
3 12.49 HRAS KRAS MLH1 MSH2 MSH6
4
Show member pathways
12.39 CDX2 HRAS KRAS MLH1 MUC2
5
Show member pathways
12.19 HRAS KRAS MUC2 MUC6
6 11.93 KRAS MSH2 MSH6
7 11.82 MLH1 MSH2 PMS2
8 11.78 KRAS MLH1 MSH2 MSH6
9 11.5 MLH1 MSH2 MSH6
10
Show member pathways
11.45 MLH1 MSH2 MSH6 PMS2
11 10.96 HRAS KRAS MLH1 MSH2 MSH6
12 10.92 HRAS KRAS
13 10.89 HRAS KRAS
14 10.84 HRAS KRAS
15 10.62 HRAS KRAS
16 10.39 MLH1 MSH2 MSH6 PMS2
17 10.25 MUC6 SCT

GO Terms for Small Intestine Cancer

Cellular components related to Small Intestine Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 MLH1 PMS2
2 MutSalpha complex GO:0032301 8.96 MSH2 MSH6
3 mismatch repair complex GO:0032300 8.92 MLH1 MSH2 MSH6 PMS2

Biological processes related to Small Intestine Cancer according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.91 MEN1 MLH1 MSH2 MSH6 PMS2
2 DNA repair GO:0006281 9.8 MEN1 MLH1 MSH2 MSH6 PMS2
3 negative regulation of neuron apoptotic process GO:0043524 9.77 HRAS KRAS MSH2
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.63 MLH1 MSH2 MSH6
5 regulation of long-term neuronal synaptic plasticity GO:0048169 9.61 HRAS KRAS
6 negative regulation of DNA recombination GO:0045910 9.59 MSH2 MSH6
7 determination of adult lifespan GO:0008340 9.58 MSH2 MSH6
8 maintenance of gastrointestinal epithelium GO:0030277 9.58 MUC2 MUC6
9 positive regulation of isotype switching to IgG isotypes GO:0048304 9.57 MLH1 MSH2
10 positive regulation of helicase activity GO:0051096 9.56 MSH2 MSH6
11 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.56 HRAS KRAS MUC2 MUC6
12 pyrimidine dimer repair GO:0006290 9.55 MSH2 MSH6
13 response to isolation stress GO:0035900 9.54 HRAS KRAS
14 replication fork arrest GO:0043111 9.52 MSH2 MSH6
15 isotype switching GO:0045190 9.5 MLH1 MSH2 MSH6
16 maintenance of DNA repeat elements GO:0043570 9.49 MSH2 MSH6
17 positive regulation of isotype switching to IgA isotypes GO:0048298 9.48 MLH1 MSH2
18 mismatch repair GO:0006298 9.46 MLH1 MSH2 MSH6 PMS2
19 meiotic mismatch repair GO:0000710 9.43 MSH2 MSH6
20 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.37 MLH1 MSH2
21 somatic recombination of immunoglobulin gene segments GO:0016447 9.13 MLH1 MSH2 MSH6
22 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 MLH1 MSH2 MSH6 PMS2

Molecular functions related to Small Intestine Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.83 MEN1 MLH1 MSH2 MSH6
2 ATPase activity GO:0016887 9.8 MLH1 MSH2 MSH6 PMS2
3 single-stranded DNA binding GO:0003697 9.69 MLH1 MSH2 PMS2
4 double-stranded DNA binding GO:0003690 9.56 CDX2 MEN1 MSH2 MSH6
5 MutLalpha complex binding GO:0032405 9.48 MSH2 MSH6
6 MutSalpha complex binding GO:0032407 9.46 MLH1 PMS2
7 oxidized purine DNA binding GO:0032357 9.43 MSH2 MSH6
8 Y-form DNA binding GO:0000403 9.4 MEN1 MSH2
9 single thymine insertion binding GO:0032143 9.37 MSH2 MSH6
10 four-way junction DNA binding GO:0000400 9.33 MEN1 MSH2 MSH6
11 single guanine insertion binding GO:0032142 9.32 MSH2 MSH6
12 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
13 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS2

Sources for Small Intestine Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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