MCID: SML016
MIFTS: 51

Small Intestine Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Small Intestine Cancer

MalaCards integrated aliases for Small Intestine Cancer:

Name: Small Intestine Cancer 12 53 15
Small Intestine Carcinoma 12 15 17 72
Malignant Neoplasms of the Small Intestine 53
Malignant Tumor of Small Intestine 72
Neoplasm of Small Intestine 72
Small Intestinal Carcinoma 12
Cancer of the Small Bowel 12
Small Bowel Cancer 12
Small Bowel Tumors 53

Classifications:



External Ids:

Disease Ontology 12 DOID:10154 DOID:4907
ICD9CM 35 152.9
NCIt 50 C7523 C7724
SNOMED-CT 68 94048009
ICD10 33 C17 C17.9
UMLS 72 C0153425 C0238196 C0345832

Summaries for Small Intestine Cancer

Disease Ontology : 12 A small intestine cancer that develops from epithelial cells and is located in the small intestine.

MalaCards based summary : Small Intestine Cancer, also known as small intestine carcinoma, is related to small intestine adenocarcinoma and gallbladder cancer. An important gene associated with Small Intestine Cancer is MLH1 (MutL Homolog 1), and among its related pathways/superpathways are DNA Double-Strand Break Repair and fMLP Pathway. The drugs Prucalopride and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and t cells, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Synthetic lethal with vaccinia virus (VACV) infection

Wikipedia : 75 Small intestine cancer is a cancer of the small intestine. It is relatively rare compared to other... more...

Related Diseases for Small Intestine Cancer

Diseases in the Small Intestine Cancer family:

Large Intestine Cancer Intestine Carcinoma in Situ
Rare Carcinoma of Small Intestine

Diseases related to Small Intestine Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
# Related Disease Score Top Affiliating Genes
1 small intestine adenocarcinoma 32.8 USP10 MUC6 MLH1
2 gallbladder cancer 31.6 TP53 MUC1 MLH1 KRAS
3 duodenum cancer 30.3 MUC6 MUC1 KRT7 KRAS HRAS CDX2
4 neurofibromatosis, type iv, of riccardi 30.2 PMS2 MSH6 HRAS
5 familial colorectal cancer 30.2 TP53 MSH2 MLH1
6 appendix adenocarcinoma 30.0 KRT7 CDX2
7 jejunal adenocarcinoma 29.7 MSH6 KRT7 CDX2
8 peutz-jeghers syndrome 29.7 TP53 SMAD4 CTNNB1
9 colon adenocarcinoma 29.6 MSH6 MLH1 KRAS CTNNB1
10 duodenum adenocarcinoma 29.6 MUC6 KRT7 KRAS CDX2
11 mismatch repair cancer syndrome 29.4 PMS2 MSH6 MSH2 MLH1 CTNNB1
12 papillary adenocarcinoma 29.4 TP53 MUC1 KRT7
13 sarcoma 29.3 TP53 KRAS HRAS CTNNB1
14 lynch syndrome 29.1 TP53 PMS2 MSH6 MSH2 MLH1 KRAS
15 signet ring cell adenocarcinoma 29.1 MUC6 MUC1 KRT7 CDX2
16 mucinous adenocarcinoma 28.8 MUC1 MLH1 KRT7 KRAS CDX2
17 adenoma 28.7 TP53 SMAD4 MSH2 MLH1 KRAS CTNNB1
18 gastrointestinal system disease 28.7 TP53 MSH2 MLH1 KRAS HRAS CTNNB1
19 familial adenomatous polyposis 28.3 TP53 SMAD4 MSH6 MSH2 MLH1 KRAS
20 adenocarcinoma 28.3 TP53 SMAD4 MUC1 MLH1 KRAS HRAS
21 pseudomyxoma peritonei 28.2 TP53 MUC6 MUC1 KRT7 KRAS CDX2
22 esophageal cancer 27.9 TP53 SMAD4 MUC1 KRAS HRAS CTNNB1
23 gastric cancer 27.7 TP53 SMAD4 MUC6 MSH2 MLH1 KRAS
24 colonic disease 27.5 TP53 PMS2 MSH6 MSH2 MLH1 KRAS
25 intestinal disease 27.4 TP53 PMS2 MSH6 MSH2 MLH1 KRAS
26 endometrial cancer 27.1 TP53 PMS2 MSH6 MSH2 MLH1 KRT7
27 colorectal adenocarcinoma 27.0 TP53 MSH6 MSH2 MLH1 KRT7 KRAS
28 gastric adenocarcinoma 26.5 TP53 SMAD4 MUC1 MLH1 KRT7 KRAS
29 gastrointestinal system cancer 26.1 TP53 SMAD4 PMS2 MSH6 MSH2 MLH1
30 colorectal cancer 25.1 TP53 SMAD4 PMS2 MUC6 MUC1 MSH6
31 small intestine cancer, childhood 12.4
32 small intestine carcinoid neuroendocrine tumor 11.1
33 ileum cancer 11.1
34 colorectal cancer, hereditary nonpolyposis, type 7 10.7 MSH2 MLH1
35 spindle cell intraocular melanoma 10.7 PMS2 MLH1
36 lower lip cancer 10.7 MSH2 MLH1
37 attenuated familial adenomatous polyposis 10.7 MSH6 MSH2
38 anal fistula 10.6 MSH2 MLH1
39 polyposis syndrome, hereditary mixed, 1 10.6 MUC6 MLH1
40 colorectal cancer 5 10.6 MSH6 MLH1
41 sigmoid neoplasm 10.6 KRAS HRAS
42 mucinous intrahepatic cholangiocarcinoma 10.6 MUC6 CDX2
43 actinic cheilitis 10.5 TP53 MSH2
44 lip cancer 10.5 TP53 MSH2
45 paronychia 10.5 KRAS HRAS
46 cervical polyp 10.5 MUC6 CDX2
47 colorectal cancer, hereditary nonpolyposis, type 4 10.5 PMS2 MSH2 MLH1
48 colorectal cancer, hereditary nonpolyposis, type 5 10.5 MSH6 MSH2 MLH1
49 periampullary adenoma 10.5 KRAS HRAS
50 rare adenocarcinoma of the breast 10.5 TP53 KRAS

Comorbidity relations with Small Intestine Cancer via Phenotypic Disease Network (PDN):


Colorectal Cancer Deficiency Anemia
Intestinal Obstruction

Graphical network of the top 20 diseases related to Small Intestine Cancer:



Diseases related to Small Intestine Cancer

Symptoms & Phenotypes for Small Intestine Cancer

GenomeRNAi Phenotypes related to Small Intestine Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.35 MLH1 MSH2 MSH6 PMS2 TP53
2 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 CDX2 KRAS MLH1 MSH6 PMS2

MGI Mouse Phenotypes related to Small Intestine Cancer:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 ARID1A CDX2 CTNNB1 KRAS KRT7 MLH1
2 homeostasis/metabolism MP:0005376 10.18 ARID1A CDX2 CTNNB1 HRAS KRAS KRT7
3 digestive/alimentary MP:0005381 10.13 CDX2 CTNNB1 HRAS KRAS MLH1 MSH2
4 endocrine/exocrine gland MP:0005379 10.11 ARID1A CDX2 CTNNB1 HRAS KRAS MLH1
5 hematopoietic system MP:0005397 10.09 ARID1A CTNNB1 KRAS MLH1 MSH2 MSH6
6 mortality/aging MP:0010768 10.03 ARID1A CDX2 CTNNB1 HRAS KRAS MLH1
7 immune system MP:0005387 10.02 ARID1A CTNNB1 KRAS MLH1 MSH2 MSH6
8 craniofacial MP:0005382 9.97 ARID1A CTNNB1 HRAS KRAS SMAD4 TP53
9 integument MP:0010771 9.92 CTNNB1 HRAS KRAS MLH1 MSH2 MSH6
10 neoplasm MP:0002006 9.9 ARID1A CDX2 CTNNB1 HRAS KRAS MLH1
11 renal/urinary system MP:0005367 9.43 CTNNB1 HRAS KRAS KRT7 SMAD4 TP53
12 reproductive system MP:0005389 9.23 ARID1A CDX2 CTNNB1 KRAS MLH1 PMS2

Drugs & Therapeutics for Small Intestine Cancer

Drugs for Small Intestine Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prucalopride Approved Phase 4 179474-81-8
2 Gastrointestinal Agents Phase 4
3 Neurotransmitter Agents Phase 4
4 Serotonin Agents Phase 4
5 Serotonin Receptor Agonists Phase 4
6 Cathartics Phase 4
7 Laxatives Phase 4
8
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
9
Ondansetron Approved Phase 3 99614-02-5 4595
10
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
11 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
12 Cola Phase 3
13 Liver Extracts Phase 3
14 Antineoplastic Agents, Hormonal Phase 3
15 Antiemetics Phase 3
16 Peripheral Nervous System Agents Phase 3
17 Serotonin Antagonists Phase 3
18 Autonomic Agents Phase 3
19 Hormone Antagonists Phase 3
20 Central Nervous System Depressants Phase 3
21 HIV Protease Inhibitors Phase 3
22 Anti-Inflammatory Agents Phase 3
23 Tranquilizing Agents Phase 3
24 Psychotropic Drugs Phase 3
25 glucocorticoids Phase 3
26 Anti-Anxiety Agents Phase 3
27 Dermatologic Agents Phase 3
28 Antipruritics Phase 3
29
protease inhibitors Phase 3
30 Antipsychotic Agents Phase 3
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
32 Analgesics Phase 3
33 Anesthetics, Intravenous Phase 3
34 Narcotics Phase 3
35 Analgesics, Opioid Phase 3
36 Adjuvants, Anesthesia Phase 3
37 Anesthetics, General Phase 3
38 Anesthetics Phase 3
39
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
40
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 43805 6857599
41
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
42
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
43
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
44
Gemcitabine Approved Phase 2 95058-81-4 60750
45
Lenograstim Approved, Investigational Phase 2 135968-09-1
46
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
47
Fluorouracil Approved Phase 2 51-21-8 3385
48
Hydroxyurea Approved Phase 2 127-07-1 3657
49
Floxuridine Approved Phase 2 50-91-9 5790
50
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Study of the Relationship Between the Rate of Residual Platinum in the Blood and the Incidence of Persistent Neurotoxicity in Patients Treated for Gastrointestinal Cancer With Oxaliplatin Unknown status NCT00274885 Phase 4 oxaliplatin
2 The Effect of Prucalopride on Small Bowel Transit Time in Patients Undergoing Capsule Endoscopy: A Randomized Controlled Trial Unknown status NCT02806206 Phase 4 Prucalopride;Placebo
3 Does Bowel Preparation (Either as a Single or Divided Dose) Produce Better Cleansing and Diagnostic Yield Than no Preparation at All in Small Bowel Capsule Endoscopy Recruiting NCT03351972 Phase 4 Klean Prep
4 A Randomized Phase III Double-Blind Study Of Ondansetron And Dexamethasone Versus Ondansetron And Placebo In The Prophylaxis Of Radiation-Induced Emesis Completed NCT00016380 Phase 3 dexamethasone;ondansetron
5 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
6 Randomized Phase II Study of Brostallicin (PNU-166196A) Versus Doxorubicin as First Line Chemotherapy in Patients With Advanced or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
7 A Phase I/II Study of NB1011 Administered Intravenously by Continuous Infusion in an Every Second Week Regimen With Open-label Continuation in Cancers That Overexpress the Enzyme Thymidylate Synthase Completed NCT00248404 Phase 1, Phase 2 NB1011
8 A Pilot Phase I/II Trial of Enteral Wallstents for Colonic Obstruction in the Setting of Malignancy Completed NCT00004911 Phase 1, Phase 2
9 A Pilot Phase I/II Trial of Enteral Wallstents for Duodenal Obstruction in the Setting of Malignancy Completed NCT00004910 Phase 1, Phase 2
10 Octreotide for Palliation of Inoperable Bowel Obstruction: A Phase II Study Completed NCT00004895 Phase 2 octreotide acetate
11 A Phase II Trial of Gemcitabine and Docetaxel in Patients With Unresectable Leiomyosarcoma Completed NCT00004066 Phase 2 docetaxel;gemcitabine hydrochloride
12 Phase II Study of Abraxane in CIMP-High Colorectal Adenocarcinomas and Small Bowel Adenocarcinomas Completed NCT01730586 Phase 2 Abraxane
13 Phase II Trial of 2-Fluorouracil Recombinant Alpha-2a-Interferon and Intravenous Hydroxyurea With Filgrastim in Patients With Refractory GI Malignancies Grant Application Title: Parenteral Hydroxyurea: A Modulator in Pancreatic Cancer Completed NCT00019474 Phase 2 fluorouracil;hydroxyurea
14 Pilot Study of Intraperitoneal (IP) Therapy With Cisplatin or Carboplatin and Floxuridine (FUdR) as Consolidation for Ovarian and Gastrointestinal Malignancies Completed NCT00005049 Phase 2 carboplatin;cisplatin;floxuridine
15 Phase II Study of Panitumumab in KRAS Wild-type Locally Advanced or Metastatic Adenocarcinoma of the Small Bowel or Ampulla of Vater Completed NCT01202409 Phase 2 Panitumumab
16 A Phase II Study Of Hepatic Arterial Infusion Of Melphalan With Venous Filtration Via Peripheral Hepatic Perfusion (PHP) For Unresectable Primary And Metastatic Cancers Of The Liver Completed NCT00096083 Phase 2 isolated perfusion;melphalan
17 A Phase II Trial of Pharmacogenetic-Based Dosing of Irinotecan, Oxaliplatin, and Capecitabine as First-Line Therapy for Advanced Small Bowel Adenocarcinoma Completed NCT00433550 Phase 2 capecitabine;irinotecan hydrochloride;oxaliplatin
18 A Phase II Study of Capecitabine and Oxaliplatin (XELOX) in Adenocarcinoma of the Small Bowel and Ampulla of Vater Completed NCT00354887 Phase 2 Capecitabine;Oxaliplatin
19 Pilot Study to Investigate the Safety and Efficacy of Avelumab Monotherapy in Patients With Advanced or Metastatic Adenocarcinoma of the Small Intestine Active, not recruiting NCT03000179 Phase 2 Avelumab
20 Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms Active, not recruiting NCT00445965 Phase 2
21 Phase II Study of Antineoplastons A10 and AS2-1 In Patients With Carcinoma of the Small Intestine Terminated NCT00003522 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
22 A Trial Of Vaccination With The Carcinoembryonic Antigen (CEA) Peptide Cap 1-6D With Montanide ISA 51 Adjuvant Or Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) In HLA-A2+ Patients With CEA Producing Adenocarcinomas Of Gastrointestinal (GI) Tract Origin Terminated NCT00012246 Phase 2
23 A Pilot Phase II, Randomized, Double Blind Trial of Palonosetron Versus Placebo to Prevent Radiation Therapy Induced Nausea and Vomiting Terminated NCT00903396 Phase 2 palonosetron hydrochloride
24 Study of "Same TCM Syndrome for Different Diseases" and "Same Treatment for Different Diseases" of Primary Hepatocellular Carcinoma and Colorectal Cancer Under the Perspective of System Science Unknown status NCT03189992 Phase 1 Bushen-Jianpi Dedoction;cinobufotalin injection
25 A Phase I Clinical Trial of Intrapleural Adenoviral-Mediated Interferon-beta (IFN-ß) Gene Transfer for Pleural Malignancies Unknown status NCT00066404 Phase 1
26 Pilot Study of Oxaliplatin in Combination With Capecitabine in Adult Cancer Patients Completed NCT00019773 Phase 1 capecitabine;oxaliplatin
27 Phase I Study of Intraperitoneal Recombinant Human Interleukin-12 (rhIL-12) in Patients With Peritoneal Carcinomatosis, Associated With Mullerian and Gastrointestinal Carcinomas Completed NCT00003046 Phase 1
28 A Phase I Study of Intraperitoneal Oxaliplatin Alone and in Combination With Intraperitoneal Floxuridine and Leucovorin in Patients With Advanced Metastatic Cancer Confined to the Peritoneal Cavity Completed NCT00005860 Phase 1 floxuridine;leucovorin calcium;oxaliplatin
29 Phase I Clinical Study of Every Three Week Irinotecan With Oral Capecitabine Given Twice Daily for Two Weeks Out of Three in Patients With Gastrointestinal and Other Solid Malignancies Completed NCT00003867 Phase 1 capecitabine;irinotecan hydrochloride
30 Phase I Study of Intraperitoneal Administration of 9-Amino-20(S)-Camptothecin to Patients With Cancer Predominantly Confined to the Peritoneal Cavity Completed NCT00003548 Phase 1 aminocamptothecin colloidal dispersion
31 A Phase I Dose-Escalating Study of Recombinant Human Interleukin-12 (NSC # 672423) Administered by Intraperitoneal Infusion in Refractory Advanced Stage Ovarian Cancer and Other Abdominal Carcinomatosis Completed NCT00003439 Phase 1
32 Phase I Study to Evaluate the Combination Chemotherapy Regimen of Oxaliplatin Plus Irinotecan in Previously Treated Patients With Metastatic Gastrointestinal Cancer Completed NCT00003427 Phase 1 irinotecan hydrochloride;oxaliplatin
33 A Pharmacogenetic-Based Phase I Trial of Irinotecan, 5-Fluorouracil, and Leucovorin (FOLFIRI) in Patients With Advanced Gastrointestinal Cancer Completed NCT00654160 Phase 1 fluorouracil;irinotecan hydrochloride;leucovorin calcium
34 A Phase I, Multi-Dose Study of RAV12 (ANTI-RAAG12 MAB) in Patients With Metastatic or Recurrent Adenocarcinoma Completed NCT00101972 Phase 1
35 Phase I Study of T Cells Modified With Chimeric AntiCEA Immunoglobulin-T Cell Receptors (IgTCR) in Adenocarcinoma Completed NCT00004178 Phase 1
36 A Phase I Clinical Trial To Assess The Safety And Efficacy Of Intraperitoneal PV701 Administrations In Patients With Advanced Or Recurrent Malignancy Largely Confined To The Peritoneal Cavity Completed NCT00055705 Phase 1
37 PHASE I PILOT STUDY OF SEQUENTIAL HIGH DOSE CYCLES OF CISPLATIN, CYCLOPHOSPHAMIDE, ETOPOSIDE AND IFOSFAMIDE, CARBOPLATIN AND TAXOL WITH AUTOLOGOUS STEM CELL SUPPORT Completed NCT00002854 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;mesna;paclitaxel
38 A Phase I Study of Oral Fluoropyrimidine Capecitabine (Xeloda Roche) Combined With Intravenous Cisplatin in Patients With Advanced Cancer of the Digestive System Completed NCT00010023 Phase 1 capecitabine;cisplatin
39 A Phase I, Pharmacokinetic, and Biologic Correlative Study of R115777 (NSC 702818) and Herceptin in Patients With Advanced Cancer Completed NCT00005842 Phase 1 tipifarnib
40 Phase I Pharmacokinetic Trial of Thalidomide and Docetaxel: A Regimen Based on Anti-Angiogenic Therapeutic Principles Completed NCT00049296 Phase 1 docetaxel;thalidomide
41 A Capsule Endoscopy and Double Balloon Enteroscopy Sequential Approach for Early Detection of Gastrointestinal Tumors in Celiac Disease: a Prospective Trial Unknown status NCT02325232
42 Open Prospective Single Center Study for the Determination of Correlation Between Video Capsule Period of Retention in the Stomach and Symptoms of Gastroparesis Unknown status NCT01858220
43 Endoscopic Evaluation of the Incidence and Etiology of Lower Gastrointestinal Bleeding in Patients Presenting With Melena Completed NCT00164723
44 Vegetable Garden Feasibility Trial to Promote Function in Older Cancer Survivors Completed NCT02150148
45 Capsule Endoscopy in Lynch Syndrome for Small Intestinal Tumor Screening Completed NCT00898768 Early Phase 1
46 Assessing the Clinical Significance of Real-time Quality of Life Data in Cancer Patients Treated With Radiation Therapy Completed NCT00836992
47 Improving Palliative Care for Patients With Cancer Completed NCT00253383
48 A Prospective Comparison of Diagnostic Efficacy and Radiomics Study in the Diagnosis and Therapeutic Efficacy Evaluation of Small Bowel Tumor With Dual-phase Enhanced Computed Tomography (CTE) and Magnetic Resonance Enterography (MRE) Recruiting NCT03659357
49 Development of a Prospective Clinicobiological Database in Metastatic Digestive Cancers Recruiting NCT03978078
50 The Role of TAB3 Protein in Tumorigenesis Terminated NCT00899132

Search NIH Clinical Center for Small Intestine Cancer

Genetic Tests for Small Intestine Cancer

Anatomical Context for Small Intestine Cancer

MalaCards organs/tissues related to Small Intestine Cancer:

41
Small Intestine, Liver, T Cells, Colon, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Small Intestine Cancer:

19
Small Intestine

Publications for Small Intestine Cancer

Articles related to Small Intestine Cancer:

(show top 50) (show all 56)
# Title Authors PMID Year
1
Epidemiology of Cancers of the Small Intestine: Trends, Risk Factors, and Prevention. 38
30884915 2019
2
Diabetes in midlife and risk of cancer in late life: A nationwide Swedish twin study. 38
29566433 2018
3
Adiposity and risks of colorectal and small intestine cancer in Chinese adults: a prospective study of 0.5 million people. 38
29872150 2018
4
Body mass index and gastrointestinal cancer mortality in Korean adults: A prospective cohort study. 38
29406580 2018
5
[Asystole during surgery to manage small intestine cancer: are we dealing with anaphylaxis or carcinoid crisis]. 38
30344876 2018
6
Incidentally Detected Small Intestine Intussusception Caused by Primary Small Intestine Carcinoma on 18F-FDG PET/CT. 38
28878855 2017
7
Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis. 38
28416491 2017
8
A systematic review of the possible carcinogenic role of the aristolochic acid. 38
28523296 2017
9
[A Case of a Single Incisional Laparoscopic Assisted Partial Jejunectomy Performed to Treat a Primary Small Intestine Cancer in a Young Woman]. 38
28133098 2016
10
Temporal Trends, Predictors, and Outcomes of In-Hospital Gastrointestinal Bleeding Associated With Percutaneous Coronary Intervention. 38
27642112 2016
11
Cost of specific emergency general surgery diseases and factors associated with high-cost patients. 38
26502214 2016
12
Chemoprevention trials of GI cancers in Asia. 38
26651257 2015
13
[A Case of Small Intestinal Cancer Repeating an Ileus Symptom Complicated with Refractory Arrhythmia]. 38
26805146 2015
14
Survival for oesophageal, stomach and small intestine cancers in Europe 1999-2007: Results from EUROCARE-5. 38
26421818 2015
15
Empirical Likelihood for Censored Linear Regression and Variable Selection. 38
31097849 2015
16
Focus on the diagnostic problems of primary adenocarcinoma of the third and fourth portion of the duodenum. Case report. 38
26712074 2015
17
[A case of an elderly patient who underwent single-incision laparoscopic surgery for small intestine cancer]. 38
25731551 2014
18
Is additional enrichment of diet in branched-chain amino acids or glutamine beneficial for patients receiving total parenteral nutrition after gastrointestinal cancer surgery? 38
24979515 2014
19
Increased incidence of gastrointestinal cancers among patients with pyogenic liver abscess: a population-based cohort study. 38
24095786 2014
20
An unusual cause of the ileus: non-specific stenosing ulceration of the small intestine. 38
23390850 2012
21
Incidence, prevalence and survival of patients with rare epithelial digestive cancers diagnosed in Europe in 1995-2002. 38
22169462 2012
22
Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine--a pooled analysis of over 500,000 subjects in the Asia Cohort Consortium. 38
22147734 2012
23
Antioxidants in patients receiving total parenteral nutrition after gastrointestinal cancer surgery. 38
22125185 2012
24
Role of solar UVB irradiance and smoking in cancer as inferred from cancer incidence rates by occupation in Nordic countries. 38
22928078 2012
25
Sugars in diet and risk of cancer in the NIH-AARP Diet and Health Study. 38
21328345 2012
26
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. 38
22180306 2012
27
[A case report of multiple adenocarcinoma in small intestine after total gastrectomy by Roux-en-Y re-construction]. 38
22202278 2011
28
Epidemiology of cancer of the small intestine. 38
21461167 2011
29
[Two cases of the primary small intestine cancer successfully treated with S-1 and UFT/LV therapy]. 38
21224714 2010
30
SEMIPARAMETRIC ADDITIVE RISKS REGRESSION FOR TWO-STAGE DESIGN SURVIVAL STUDIES. 38
21931467 2010
31
Small intestinal adenocarcinoma in common marmosets (Callithrix jacchus). 38
20460447 2010
32
Small intestinal cancer: a population-based study of incidence and survival patterns in the United States, 1992 to 2006. 38
20647399 2010
33
Patient with eight metachronous gastrointestinal cancers thought to be hereditary nonpolyposis colorectal cancer (HNPCC). 38
20118596 2010
34
Hemorrhagic small intestine cancer with solitary pulmonary metastasis initially presented as suspected primary lung cancer: an autopsy report. 38
18432067 2007
35
Socioeconomic and geographic determinants of survival of patients with digestive cancer in France. 38
16969351 2006
36
Associations between small intestine cancer and other primary cancers: an international population-based study. 38
16003748 2006
37
[Case with double primary cancers occurring synchronously in both the lung and jejunum diagnosed according to TTF-1 expression]. 38
15770938 2005
38
Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases. 38
15231648 2004
39
Up-regulation in dihydropyrimidine dehydrogenase activity by raltitrexed causes antagonism in combination with 5-fluorouracil. 38
14981911 2003
40
Leiomyosarcoma of the small intestine found within an inguinal hernia sac: a case report. 38
12914376 2003
41
Cancer incidence among Swedish patients exposed to radioactive thorotrast: a forty-year follow-up survey. 38
11893244 2002
42
Iron deficiency anemia as the sole symptom of small intestine carcinoma. 38
11386025 2001
43
[Metastatic small intestine carcinoma--delayed diagnosis due to misinterpretation of diagnostic imaging and symptom confusion due to Bechterew disease and duodenal ulcer]. 38
10923361 2000
44
Cyclic core dendrimer as a new kind of vector for gene transfer into mammalian cells. 38
11145421 2000
45
Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) criteria and results of genetic diagnosis. 38
10378593 1999
46
Effect of tea extracts, polyphenols, and epigallocatechin gallate on azoxymethane-induced colon cancer. 38
9421213 1998
47
[Duodenal adenocarcinoma in celiac disease with late diagnosis and treatment]. 38
9280612 1997
48
[Study of p53 protein expression in cancers of small intestine and its relationship to clinical course and prognosis]. 38
9387321 1996
49
Risk factors for small intestine cancer. 38
8481495 1993
50
Small intestine carcinoma in the Peutz-Jeghers syndrome. 38
2634217 1989

Variations for Small Intestine Cancer

Expression for Small Intestine Cancer

Search GEO for disease gene expression data for Small Intestine Cancer.

Pathways for Small Intestine Cancer

Pathways related to Small Intestine Cancer according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.13 USP10 TP53 PMS2 MSH6 MSH2 MLH1
2
Show member pathways
12.92 TP53 KRAS HRAS CTNNB1 CDX2
3
Show member pathways
12.87 TP53 SMAD4 KRAS HRAS CTNNB1
4
Show member pathways
12.82 TP53 MSH6 MSH2 MLH1 KRAS HRAS
5
Show member pathways
12.67 TP53 SMAD4 MSH6 MSH2 MLH1 KRAS
6
Show member pathways
12.51 TP53 MSH2 KRAS HRAS CTNNB1
7 12.48 TP53 SMAD4 MSH6 MSH2 MLH1 KRAS
8 12.42 USP10 TP53 MSH6 MSH2 MLH1
9
Show member pathways
12.36 TP53 KRAS HRAS CTNNB1
10
Show member pathways
12.35 MUC6 MUC1 KRAS HRAS
11 12.23 TP53 SMAD4 KRAS HRAS CTNNB1
12 12.22 TP53 KRAS HRAS CTNNB1
13
Show member pathways
12.22 TP53 SMAD4 MLH1 KRAS HRAS CTNNB1
14 12.03 SMAD4 KRAS HRAS CTNNB1
15 11.98 TP53 PMS2 MSH2 MLH1
16 11.94 KRAS HRAS CTNNB1
17 11.92 TP53 KRAS HRAS
18 11.92 TP53 SMAD4 KRAS HRAS CTNNB1
19 11.92 TP53 SMAD4 MSH6 MSH2 KRAS CTNNB1
20 11.91 TP53 KRAS HRAS CTNNB1
21 11.87 TP53 SMAD4 HRAS
22 11.87 TP53 KRAS HRAS CTNNB1
23 11.83 SMAD4 KRAS HRAS
24
Show member pathways
11.79 PMS2 MSH6 MSH2 MLH1
25
Show member pathways
11.75 TP53 MSH6 MSH2
26 11.67 TP53 KRAS HRAS
27 11.64 TP53 MSH6 MSH2 MLH1
28 11.63 TP53 KRAS HRAS
29 11.62 TP53 HRAS ARID1A
30 11.61 TP53 KRAS HRAS
31 11.55 SMAD4 HRAS CTNNB1
32 11.45 TP53 MSH6 MSH2 MLH1 KRAS HRAS
33 11.44 TP53 MSH6 MSH2
34 11.38 TP53 SMAD4 MSH6 MSH2 MLH1 KRAS
35
Show member pathways
11.37 TP53 MSH2 MLH1
36 11.25 TP53 KRAS HRAS
37 11.21 SMAD4 KRAS HRAS CTNNB1
38 11.17 PMS2 MSH6 MSH2 MLH1
39 10.78 KRAS HRAS

GO Terms for Small Intestine Cancer

Cellular components related to Small Intestine Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.97 USP10 TP53 SMAD4 PMS2 MUC1 MSH6
2 nucleoplasm GO:0005654 9.96 USP10 TP53 SMAD4 PMS2 MSH6 MSH2
3 MutLalpha complex GO:0032389 9.37 PMS2 MLH1
4 nuclear chromatin GO:0000790 9.35 TP53 SMAD4 MUC1 MSH6 ARID1A
5 MutSalpha complex GO:0032301 9.32 MSH6 MSH2
6 mismatch repair complex GO:0032300 8.92 PMS2 MSH6 MSH2 MLH1

Biological processes related to Small Intestine Cancer according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 DNA repair GO:0006281 9.88 USP10 PMS2 MSH6 MSH2 MLH1
2 cellular response to DNA damage stimulus GO:0006974 9.88 USP10 TP53 PMS2 MSH6 MSH2 MLH1
3 cell proliferation GO:0008283 9.81 TP53 SMAD4 CTNNB1
4 Ras protein signal transduction GO:0007265 9.74 TP53 KRAS HRAS
5 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.69 MSH6 MSH2 MLH1
6 gastrulation with mouth forming second GO:0001702 9.63 SMAD4 CTNNB1
7 negative regulation of DNA recombination GO:0045910 9.63 MSH6 MSH2
8 intrinsic apoptotic signaling pathway GO:0097193 9.63 TP53 MSH6 HRAS
9 epithelial tube branching involved in lung morphogenesis GO:0060441 9.62 KRAS CTNNB1
10 positive regulation of histone H3-K4 methylation GO:0051571 9.62 SMAD4 CTNNB1
11 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.61 USP10 TP53
12 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.61 TP53 MUC1
13 positive regulation of isotype switching to IgG isotypes GO:0048304 9.59 MSH2 MLH1
14 chromatin-mediated maintenance of transcription GO:0048096 9.58 CTNNB1 ARID1A
15 positive regulation of helicase activity GO:0051096 9.58 MSH6 MSH2
16 response to isolation stress GO:0035900 9.56 KRAS HRAS
17 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.56 MUC6 MUC1 KRAS HRAS
18 positive regulation of isotype switching to IgA isotypes GO:0048298 9.54 MSH2 MLH1
19 isotype switching GO:0045190 9.54 MSH6 MSH2 MLH1
20 maintenance of DNA repeat elements GO:0043570 9.52 MSH6 MSH2
21 determination of adult lifespan GO:0008340 9.5 TP53 MSH6 MSH2
22 mismatch repair GO:0006298 9.46 PMS2 MSH6 MSH2 MLH1
23 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.43 MSH2 MLH1
24 pyrimidine dimer repair GO:0006290 9.25 MSH6
25 meiotic mismatch repair GO:0000710 9.19 MSH6
26 somatic recombination of immunoglobulin gene segments GO:0016447 9.13 MSH6 MSH2 MLH1
27 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 PMS2 MSH6 MSH2 MLH1
28 positive regulation of transcription, DNA-templated GO:0045893 10 TP53 SMAD4 CTNNB1 CDX2 ARID1A

Molecular functions related to Small Intestine Cancer according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.81 PMS2 MSH6 MSH2 MLH1
2 double-stranded DNA binding GO:0003690 9.73 MSH6 MSH2 CDX2
3 enzyme binding GO:0019899 9.72 TP53 MSH6 MSH2 MLH1 CTNNB1
4 single-stranded DNA binding GO:0003697 9.71 PMS2 MSH2 MLH1
5 chromatin binding GO:0003682 9.63 TP53 SMAD4 MSH6 MSH2 MLH1 CTNNB1
6 p53 binding GO:0002039 9.61 USP10 TP53 MUC1
7 four-way junction DNA binding GO:0000400 9.55 MSH6 MSH2
8 RNA polymerase II transcription factor binding GO:0001085 9.54 TP53 SMAD4 CTNNB1
9 I-SMAD binding GO:0070411 9.52 SMAD4 CTNNB1
10 oxidized purine DNA binding GO:0032357 9.49 MSH6 MSH2
11 MutSalpha complex binding GO:0032407 9.48 PMS2 MLH1
12 MutLalpha complex binding GO:0032405 9.46 MSH6 MSH2
13 single thymine insertion binding GO:0032143 9.4 MSH6 MSH2
14 single guanine insertion binding GO:0032142 9.26 MSH6 MSH2
15 guanine/thymine mispair binding GO:0032137 9.13 MSH6 MSH2 MLH1
16 mismatched DNA binding GO:0030983 8.92 PMS2 MSH6 MSH2 MLH1

Sources for Small Intestine Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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