MCID: SML006
MIFTS: 26

Small Intestine Leiomyoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Small Intestine Leiomyoma

MalaCards integrated aliases for Small Intestine Leiomyoma:

Name: Small Intestine Leiomyoma 12 15
Leiomyoma of Small Intestine 70
Leiomyoma, Small Bowel 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1738
NCIt 50 C7725
SNOMED-CT 67 424279009
UMLS 70 C0238197

Summaries for Small Intestine Leiomyoma

Disease Ontology : 12 A small intestine benign neoplasm that is located in the small intestine.

MalaCards based summary : Small Intestine Leiomyoma, also known as leiomyoma of small intestine, is related to leiomyoma and cerebral convexity meningioma. An important gene associated with Small Intestine Leiomyoma is ANO1 (Anoctamin 1), and among its related pathways/superpathways are Neuroscience and Glioblastoma Multiforme. Affiliated tissues include small intestine, and related phenotypes are integument and hearing/vestibular/ear

Related Diseases for Small Intestine Leiomyoma

Diseases related to Small Intestine Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
# Related Disease Score Top Affiliating Genes
1 leiomyoma 29.4 PTCH1 PDGFRA KIT CD34
2 cerebral convexity meningioma 10.3 NF2 ANO1
3 neurilemmoma of the fifth cranial nerve 10.3 NF2 NF1
4 trigeminal nerve neoplasm 10.3 NF2 NF1
5 cerebral falx meningioma 10.3 NF2 NF1
6 peripheral nerve schwannoma 10.3 NF2 NF1
7 optic nerve sheath meningioma 10.2 NF2 NF1
8 urethra leiomyoma 10.2 KIT CALD1
9 esophageal adenoid cystic carcinoma 10.2 KIT ANO1
10 prostate embryonal rhabdomyosarcoma 10.2 KIT CALD1
11 gastric hemangioma 10.2 KIT ANO1
12 optic nerve neoplasm 10.2 NF2 NF1
13 corpus callosum lipoma 10.2 NF2 NF1
14 cerebral hemisphere lipoma 10.2 NF2 NF1
15 spinal canal and spinal cord meningioma 10.2 NF2 NF1
16 spinal meningioma 10.2 NF2 NF1
17 perineurioma 10.2 NF1 KIT
18 ovarian melanoma 10.2 MLANA CALD1
19 active peptic ulcer disease 10.2 KIT ANO1
20 reticular perineurioma 10.2 PDGFRA KIT
21 rare tumor 10.2 NF2 KIT
22 laryngeal small cell carcinoma 10.2 PDGFRA KIT
23 uterus perivascular epithelioid cell tumor 10.2 MLANA CALD1
24 pulmonary vein stenosis 10.2 PDGFRA KIT
25 spinal cancer 10.2 NF2 NF1
26 esophagus leiomyoma 10.2 PDGFRA NF1
27 mixed glioma 10.2 PDGFRA NF1
28 melanotic neurilemmoma 10.2 NF2 MLANA
29 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.2 PDGFRA KIT
30 hypereosinophilic syndrome, idiopathic 10.2 PDGFRA KIT
31 sm-ahnmd 10.1 PDGFRA KIT
32 malignant triton tumor 10.1 NF1 MLANA
33 endometrial small cell carcinoma 10.1 PDGFRA KIT
34 salpingitis isthmica nodosa 10.1 NF2 MBP
35 obstructive hydrocephalus 10.1 NF2 NF1
36 nasal cavity adenocarcinoma 10.1 MLANA ANO1
37 benign ependymoma 10.1 NF2 NF1
38 malignant anus melanoma 10.1 MLANA KIT
39 brain stem cancer 10.1 PDGFRA NF1
40 malignant dermis tumor 10.1 MLANA KIT
41 carney triad 10.1 PDGFRA KIT
42 malignant skin fibrous histiocytoma 10.1 MLANA KIT
43 orbit rhabdomyosarcoma 10.1 NF1 MLANA
44 tinea capitis 10.1 PTCH1 NF2
45 thymus clear cell carcinoma 10.1 MLANA KIT
46 neurofibromatosis 10.1 PDGFRA NF2 NF1
47 glomangioma 10.1 CD34 CALD1
48 cerebellum cancer 10.1 PTCH1 NF1
49 glomus tumor 10.1 CD34 CALD1
50 gastric leiomyosarcoma 10.0 PDGFRA KIT ANO1

Graphical network of the top 20 diseases related to Small Intestine Leiomyoma:



Diseases related to Small Intestine Leiomyoma

Symptoms & Phenotypes for Small Intestine Leiomyoma

MGI Mouse Phenotypes related to Small Intestine Leiomyoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.92 ANO1 CD34 KIT MLANA NF1 NF2
2 hearing/vestibular/ear MP:0005377 9.77 KIT MBP NF1 NF2 PTCH1
3 neoplasm MP:0002006 9.73 CD34 KIT NF1 NF2 PDGFRA PTCH1
4 pigmentation MP:0001186 9.55 KIT MLANA NF1 PDGFRA PTCH1
5 renal/urinary system MP:0005367 9.43 ANO1 KIT NF1 NF2 PDGFRA PTCH1
6 respiratory system MP:0005388 9.1 ANO1 KIT NF1 NF2 PDGFRA PTCH1

Drugs & Therapeutics for Small Intestine Leiomyoma

Search Clinical Trials , NIH Clinical Center for Small Intestine Leiomyoma

Genetic Tests for Small Intestine Leiomyoma

Anatomical Context for Small Intestine Leiomyoma

The Foundational Model of Anatomy Ontology organs/tissues related to Small Intestine Leiomyoma:

19
Small Intestine

MalaCards organs/tissues related to Small Intestine Leiomyoma:

40
Small Intestine

Publications for Small Intestine Leiomyoma

Articles related to Small Intestine Leiomyoma:

# Title Authors PMID Year
1
[Complications of the small intestine leiomyoma]. 61
14997826 2003
2
[Small intestine leiomyoma]. 61
13612049 1958

Variations for Small Intestine Leiomyoma

Expression for Small Intestine Leiomyoma

Search GEO for disease gene expression data for Small Intestine Leiomyoma.

Pathways for Small Intestine Leiomyoma

Pathways related to Small Intestine Leiomyoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 NF2 NF1 MBP ANO1
2 11.18 PDGFRA NF2 NF1
3
Show member pathways
10.69 PDGFRA KIT

GO Terms for Small Intestine Leiomyoma

Cellular components related to Small Intestine Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.76 PTCH1 PDGFRA NF2 MBP KIT CD34
2 integral component of plasma membrane GO:0005887 9.65 PDGFRA MLANA KIT CD34 ANO1
3 membrane GO:0016020 9.32 PTCH1 PDGFRA NF2 NF1 MLANA MBP
4 cell surface GO:0009986 9.26 PDGFRA MBP KIT CD34

Biological processes related to Small Intestine Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.5 PTCH1 NF2 KIT
2 pigmentation GO:0043473 9.43 NF1 KIT
3 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.4 PDGFRA KIT
4 negative regulation of MAPK cascade GO:0043409 9.37 NF2 NF1
5 adrenal gland development GO:0030325 9.26 PDGFRA NF1
6 positive regulation of phospholipase C activity GO:0010863 9.16 PDGFRA KIT
7 smooth muscle tissue development GO:0048745 8.96 PTCH1 NF1
8 MAPK cascade GO:0000165 8.92 PDGFRA NF1 MBP KIT

Sources for Small Intestine Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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