MCID: SML014
MIFTS: 39

Small Intestine Leiomyosarcoma

Categories: Cancer diseases, Gastrointestinal diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Small Intestine Leiomyosarcoma

MalaCards integrated aliases for Small Intestine Leiomyosarcoma:

Name: Small Intestine Leiomyosarcoma 12 15 73
Smooth Muscle Connective Tissue Tumor 12
Leiomyosarcoma of the Small Bowel 12
Leiomyosarcoma of Small Intestine 59

Classifications:



External Ids:

Disease Ontology 12 DOID:5271
NCIt 50 C7085
Orphanet 59 ORPHA104076
ICD10 via Orphanet 34 C17.1 C17.2 C17.3 more
UMLS via Orphanet 74 C0920305
UMLS 73 C0920305

Summaries for Small Intestine Leiomyosarcoma

Disease Ontology : 12 A small intestine sarcoma that affects the involuntary smooth muscles of the small intestines.

MalaCards based summary : Small Intestine Leiomyosarcoma, also known as smooth muscle connective tissue tumor, is related to leiomyosarcoma and embryoma. An important gene associated with Small Intestine Leiomyosarcoma is IHH (Indian Hedgehog), and among its related pathways/superpathways are Innate Lymphoid Cell Differentiation Pathways and C-MYB transcription factor network. The drugs Oxaliplatin and Cola have been mentioned in the context of this disorder. Affiliated tissues include small intestine, smooth muscle and liver, and related phenotypes are Decreased human papilloma virus 16 (HPV16) pseudovirus infection and cardiovascular system

Related Diseases for Small Intestine Leiomyosarcoma

Diseases related to Small Intestine Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 30.3 IGF2 KIT
2 embryoma 10.1 IGF2 KIT
3 malignant anus melanoma 10.1 ADAM17 KIT
4 congenital mesoblastic nephroma 10.1 IGF2 KIT
5 gastric cardia carcinoma 10.0 ANO1 KIT
6 clear cell sarcoma 10.0 IGF2 KIT
7 ovarian brenner tumor 10.0 ANO1 KIT
8 gallbladder leiomyoma 10.0 CD34 KIT
9 lung leiomyosarcoma 10.0 CD34 KIT
10 deep leiomyoma 10.0 CD34 KIT
11 extracutaneous mastocytoma 10.0 CD34 KIT
12 gallbladder sarcoma 10.0 CD34 KIT
13 prostate leiomyosarcoma 10.0 CD34 KIT
14 plexiform schwannoma 10.0 CD34 KIT
15 conventional fibrosarcoma 10.0 CD34 KIT
16 peritoneal benign neoplasm 10.0 CD34 KIT
17 diffuse peritoneal leiomyomatosis 10.0 CD34 KIT
18 breast angiosarcoma 10.0 CD34 KIT
19 senile angioma 10.0 CD34 KIT
20 angiomyoma 10.0 CD34 KIT
21 spindle cell liposarcoma 10.0 CD34 KIT
22 pancreas disease 10.0 GCG IGF2
23 mesenchymal cell neoplasm 9.9 CD34 KIT
24 cardiovascular organ benign neoplasm 9.9 CD34 KIT
25 periosteal osteogenic sarcoma 9.9 CD34 IGF2
26 benign perivascular tumor 9.9 CD34 KIT
27 nervous system benign neoplasm 9.9 CD34 KIT
28 vascular cancer 9.9 CD34 KIT
29 connective tissue cancer 9.9 CD34 KIT
30 gastrointestinal system disease 9.9 ADAM17 GCG KIT
31 gastric leiomyosarcoma 9.9 ANO1 IGF2 KIT
32 neurofibroma 9.9 CD34 KIT
33 endocrine gland cancer 9.9 ADAM17 GCG IGF2
34 germ cell cancer 9.9 IGF2 KIT
35 leukocyte disease 9.8 CD34 KIT
36 leiomyoma 9.8 CD34 IGF2 KIT
37 muscle cancer 9.8 CD34 IGF2 KIT
38 dermatofibrosarcoma protuberans 9.8 CD34 KIT
39 gastrointestinal system cancer 9.8 ADAM17 CD34 KIT
40 muscular disease 9.8 CD34 IGF2 KIT
41 meninges sarcoma 9.8 CD34 GCG IGF2
42 liver leiomyoma 9.8 ANO1 CD34 KIT
43 gastrointestinal stromal tumor 9.6 ANO1 CD34 IGF2 KIT
44 small intestinal sarcoma 9.1 ADAM17 ANO1 CD34 GCG IGF2 IHH

Graphical network of the top 20 diseases related to Small Intestine Leiomyosarcoma:



Diseases related to Small Intestine Leiomyosarcoma

Symptoms & Phenotypes for Small Intestine Leiomyosarcoma

GenomeRNAi Phenotypes related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human papilloma virus 16 (HPV16) pseudovirus infection GR00306-A 8.92 GCG IGF2 IHH KIT

MGI Mouse Phenotypes related to Small Intestine Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 ADAM17 ANO1 IGF2 IHH KIT
2 digestive/alimentary MP:0005381 9.77 ADAM17 ANO1 IGF2 IHH KIT
3 integument MP:0010771 9.72 ADAM17 ANO1 CD34 IGF2 KIT
4 limbs/digits/tail MP:0005371 9.56 ADAM17 IGF2 IHH KIT
5 muscle MP:0005369 9.55 ADAM17 ANO1 IGF2 IHH KIT
6 respiratory system MP:0005388 9.35 ADAM17 ANO1 IGF2 IHH KIT
7 skeleton MP:0005390 9.02 ADAM17 ANO1 IGF2 IHH KIT

Drugs & Therapeutics for Small Intestine Leiomyosarcoma

Drugs for Small Intestine Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 113)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 4,Phase 1 61825-94-3 43805 6857599 5310940 9887054
2 Cola Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
3 Liver Extracts Phase 4,Phase 3,Phase 1,Not Applicable
4
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
5
Ondansetron Approved Phase 3 99614-02-5 4595
6
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
7
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2 1177-87-3
8
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
9
Cyproheptadine Approved Phase 3 129-03-3 2913
10 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
11 Central Nervous System Depressants Phase 3
12 Adjuvants, Anesthesia Phase 3
13 Anesthetics, Intravenous Phase 3
14 Analgesics, Opioid Phase 3
15 Peripheral Nervous System Agents Phase 3
16 Anesthetics, General Phase 3
17 Analgesics Phase 3
18 Narcotics Phase 3
19 Anesthetics Phase 3
20 BB 1101 Phase 3,Phase 2
21 Antipruritics Phase 3
22 Serotonin Agents Phase 3
23 Anti-Inflammatory Agents Phase 3
24 Hormone Antagonists Phase 3
25 Antipsychotic Agents Phase 3
26 Dermatologic Agents Phase 3,Not Applicable
27 Gastrointestinal Agents Phase 3,Phase 2
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
29 glucocorticoids Phase 3
30 Serotonin Antagonists Phase 3
31 Tranquilizing Agents Phase 3
32 Hormones Phase 3
33 Antineoplastic Agents, Hormonal Phase 3,Phase 2
34 Antiemetics Phase 3
35 Anti-Anxiety Agents Phase 3
36
protease inhibitors Phase 3
37 Autonomic Agents Phase 3
38 Psychotropic Drugs Phase 3
39 HIV Protease Inhibitors Phase 3
40 Neurotransmitter Agents Phase 3
41 Anti-Allergic Agents Phase 3
42 Histamine H1 Antagonists Phase 3
43
Histamine Phosphate Phase 3 51-74-1 65513
44 Histamine Antagonists Phase 3
45
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
46
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
47
Lenograstim Approved, Investigational Phase 2 135968-09-1
48
Dactinomycin Approved, Investigational Phase 2 50-76-0 457193 2019
49
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
50
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Relationship Between Platinum Levels in the Blood and Neurotoxicity in Patients Who Are Receiving Oxaliplatin for Gastrointestinal Cancer Unknown status NCT00274885 Phase 4 oxaliplatin
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Ondansetron With or Without Dexamethasone to Prevent Vomiting in Patients Receiving Radiation Therapy to the Upper Abdomen Completed NCT00016380 Phase 3 dexamethasone;ondansetron
4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
6 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
7 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
8 Gemcitabine, Docetaxel, and Filgrastim in Treating Patients With Recurrent or Persistent Leiomyosarcoma or Soft Tissue Sarcoma Completed NCT00004066 Phase 2 docetaxel;gemcitabine hydrochloride
9 Nitrocamptothecin in Treating Patients With Soft Tissue Sarcomas Completed NCT00005874 Phase 2 rubitecan
10 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
11 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
12 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
13 Endoscopic Placement of Metal Stent in Patients With Cancer-Related Bowel Obstruction Completed NCT00004911 Phase 1, Phase 2
14 Endoscopic Placement of Metal Stents in Treating Patients With Cancer- Related Duodenal Obstruction Completed NCT00004910 Phase 1, Phase 2
15 Octreotide as Palliative Therapy for Cancer-Related Bowel Obstruction That Cannot Be Removed by Surgery Completed NCT00004895 Phase 2 octreotide acetate
16 Combination Chemotherapy in Treating Patients With Stage III Ovarian Epithelial Cancer or Gastrointestinal Cancer Completed NCT00005049 Phase 2 carboplatin;cisplatin;floxuridine
17 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
18 Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer Completed NCT00397384 Phase 1 cetuximab;erlotinib hydrochloride
19 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
20 Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Gastrointestinal Cancer Completed NCT00654160 Phase 1 fluorouracil;irinotecan hydrochloride;leucovorin calcium
21 Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum Completed NCT00005860 Phase 1 floxuridine;leucovorin calcium;oxaliplatin
22 Irinotecan and Capecitabine in Treating Patients With Solid Tumors Completed NCT00003867 Phase 1 capecitabine;irinotecan hydrochloride
23 PV701 in Treating Patients With Advanced or Recurrent Peritoneal Cancer Completed NCT00055705 Phase 1
24 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
25 Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer Completed NCT00019773 Phase 1 capecitabine;oxaliplatin
26 Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients Completed NCT00253383 Not Applicable
27 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
28 EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer Terminated NCT00087191 Not Applicable EF5;motexafin lutetium
29 Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection Withdrawn NCT00378781 Not Applicable Heparin;Minocycline-EDTA

Search NIH Clinical Center for Small Intestine Leiomyosarcoma

Genetic Tests for Small Intestine Leiomyosarcoma

Anatomical Context for Small Intestine Leiomyosarcoma

MalaCards organs/tissues related to Small Intestine Leiomyosarcoma:

41
Small Intestine, Smooth Muscle, Liver, Colon, Lung, Prostate, Pancreas

Publications for Small Intestine Leiomyosarcoma

Articles related to Small Intestine Leiomyosarcoma:

# Title Authors Year
1
Leiomyosarcoma of the small bowel: Report of a case and review of the literature. ( 25506852 )
2015

Variations for Small Intestine Leiomyosarcoma

Expression for Small Intestine Leiomyosarcoma

Search GEO for disease gene expression data for Small Intestine Leiomyosarcoma.

Pathways for Small Intestine Leiomyosarcoma

Pathways related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.27 CD34 KIT
2 11.21 CD34 KIT
3 11.13 CD34 KIT
4 10.97 IGF2 IHH
5 10.68 CD34 KIT
6 10.35 IGF2 KIT

GO Terms for Small Intestine Leiomyosarcoma

Cellular components related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 ADAM17 ANO1 CD34

Biological processes related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.32 IGF2 IHH
2 hemopoiesis GO:0030097 9.26 CD34 KIT
3 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.16 ANO1 GCG
4 cell motility GO:0048870 8.96 ADAM17 CD34
5 positive regulation of cell proliferation GO:0008284 8.92 ADAM17 IGF2 IHH KIT

Sources for Small Intestine Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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