MCID: SML014
MIFTS: 31

Small Intestine Leiomyosarcoma

Categories: Cancer diseases, Gastrointestinal diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Small Intestine Leiomyosarcoma

MalaCards integrated aliases for Small Intestine Leiomyosarcoma:

Name: Small Intestine Leiomyosarcoma 12 15 70
Smooth Muscle Connective Tissue Tumor 12
Leiomyosarcoma of the Small Bowel 12
Leiomyosarcoma of Small Intestine 58

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


External Ids:

Disease Ontology 12 DOID:5271
NCIt 50 C7085
SNOMED-CT 67 716651004
ICD10 via Orphanet 33 C17.0 C17.1 C17.2 more
UMLS via Orphanet 71 C0920305
Orphanet 58 ORPHA104076
UMLS 70 C0920305

Summaries for Small Intestine Leiomyosarcoma

Disease Ontology : 12 A small intestine sarcoma that affects the involuntary smooth muscles of the small intestines.

MalaCards based summary : Small Intestine Leiomyosarcoma, also known as smooth muscle connective tissue tumor, is related to leiomyoma and parasagittal meningioma. An important gene associated with Small Intestine Leiomyosarcoma is ANO1 (Anoctamin 1), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drugs Ondansetron and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include small intestine, smooth muscle and liver, and related phenotype is Upregulation of Wnt pathway.

Related Diseases for Small Intestine Leiomyosarcoma

Diseases related to Small Intestine Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 leiomyoma 30.1 KIT CD34
2 parasagittal meningioma 10.1 CD34 ANO1
3 pulmonary artery leiomyosarcoma 10.1 CD34 ANO1
4 intravascular fasciitis 10.1 CD34 ANO1
5 epithelioid cell synovial sarcoma 10.1 CD34 ANO1
6 benign peritoneal mesothelioma 10.1 CD34 ANO1
7 liposarcoma 10.1
8 hypoglycemia 10.1
9 ring chromosome 13 10.1
10 gastric leiomyoma 10.0 KIT ANO1
11 gastric leiomyosarcoma 10.0 KIT ANO1
12 small intestinal sarcoma 10.0 KIT ANO1
13 esophageal adenoid cystic carcinoma 10.0 KIT ANO1
14 gastric hemangioma 10.0 KIT ANO1
15 mucinous stomach adenocarcinoma 10.0 KIT ANO1
16 inguinal hernia 10.0
17 myoma 10.0 KIT CD34
18 active peptic ulcer disease 10.0 KIT ANO1
19 spinal cord sarcoma 10.0 KIT CD34
20 gallbladder leiomyoma 10.0 KIT CD34
21 neuronal intestinal dysplasia, type b 10.0 KIT CD34
22 mucocele of appendix 10.0 KIT CD34
23 gallbladder leiomyosarcoma 10.0 KIT CD34
24 angiomyoma 10.0 KIT CD34
25 benign fibrous mesothelioma 10.0 KIT CD34
26 retroperitoneal hemangiopericytoma 10.0 KIT CD34
27 breast leiomyosarcoma 10.0 KIT CD34
28 neurofibroma 10.0 KIT CD34
29 liver fibroma 10.0 KIT CD34
30 benign perivascular tumor 10.0 KIT CD34
31 plexiform schwannoma 10.0 KIT CD34
32 heart sarcoma 10.0 KIT CD34
33 skin sarcoma 10.0 KIT CD34
34 chondroma 10.0 KIT ANO1
35 cutaneous ganglioneuroma 10.0 KIT CD34
36 vaginal endometrial stromal sarcoma 10.0 KIT CD34
37 breast malignant phyllodes tumor 10.0 KIT CD34
38 nasal cavity benign neoplasm 10.0 KIT CD34
39 glomangiomatosis 10.0 KIT CD34
40 vagina sarcoma 10.0 KIT CD34
41 benign breast phyllodes tumor 10.0 KIT CD34
42 liver leiomyosarcoma 10.0 KIT CD34
43 lung leiomyosarcoma 10.0 KIT CD34
44 esophagus sarcoma 10.0 KIT CD34
45 leiomyosarcoma 10.0
46 conventional fibrosarcoma 10.0 KIT CD34
47 meckel diverticulum 10.0 KIT CD34
48 mediastinal cancer 10.0 KIT CD34
49 uterine corpus sarcoma 10.0 KIT CD34
50 heart cancer 10.0 KIT CD34

Graphical network of the top 20 diseases related to Small Intestine Leiomyosarcoma:



Diseases related to Small Intestine Leiomyosarcoma

Symptoms & Phenotypes for Small Intestine Leiomyosarcoma

GenomeRNAi Phenotypes related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Upregulation of Wnt pathway GR00057-A-1 8.62 CD34 YWHAH

Drugs & Therapeutics for Small Intestine Leiomyosarcoma

Drugs for Small Intestine Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ondansetron Approved Phase 3 99614-02-5 4595
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
4
Cyproheptadine Approved Phase 3 129-03-3 2913
5 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
6 Psychotropic Drugs Phase 3
7 Cola Phase 3
8 Hormones Phase 3
9 glucocorticoids Phase 3
10 Hormone Antagonists Phase 3
11 Antiemetics Phase 3
12 Liver Extracts Phase 3
13 Antineoplastic Agents, Hormonal Phase 3
14 Anti-Inflammatory Agents Phase 3
15 Antipsychotic Agents Phase 3
16 Anti-Anxiety Agents Phase 3
17 Anesthetics Phase 3
18 Narcotics Phase 3
19 Analgesics, Opioid Phase 3
20 Analgesics Phase 3
21 Anesthetics, Intravenous Phase 3
22 Anesthetics, General Phase 3
23 Neurotransmitter Agents Phase 3
24 Gastrointestinal Agents Phase 3
25 Dermatologic Agents Phase 3
26
Histamine Phosphate Phase 3 51-74-1 65513
27 Histamine H1 Antagonists Phase 3
28 Histamine Antagonists Phase 3
29 Anti-Allergic Agents Phase 3
30
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
31
Floxuridine Approved Phase 2 50-91-9 5790
32
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
33
Gemcitabine Approved Phase 2 95058-81-4 60750
34
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
35
Lenograstim Approved, Investigational Phase 2 135968-09-1
36
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
37
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
38
Etoposide Approved Phase 2 33419-42-0 36462
39
Epirubicin Approved Phase 2 56420-45-2 41867
40
Dactinomycin Approved, Investigational Phase 2 50-76-0 2019 457193
41
Ifosfamide Approved Phase 2 3778-73-2 3690
42
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
43
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
44
Octreotide Approved, Investigational Phase 2 83150-76-9 6400441 383414
45
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
46
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
47
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
48
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
49
Acetaminophen Approved Phase 2 103-90-2 1983
50
Promethazine Approved, Investigational Phase 2 60-87-7 4927

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Study of the Relationship Between the Rate of Residual Platinum in the Blood and the Incidence of Persistent Neurotoxicity in Patients Treated for Gastrointestinal Cancer With Oxaliplatin Unknown status NCT00274885 Phase 4 oxaliplatin
2 A Randomized Phase III Double-Blind Study Of Ondansetron And Dexamethasone Versus Ondansetron And Placebo In The Prophylaxis Of Radiation-Induced Emesis Completed NCT00016380 Phase 3 dexamethasone;ondansetron
3 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Randomized Phase II Study of Brostallicin (PNU-166196A) Versus Doxorubicin as First Line Chemotherapy in Patients With Advanced or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
6 A Multicenter Phase II Study of Continuous Dosing of Sunitinib (Sutent®, SU11248) in Non-GIST Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
7 Phase II Study of RFS 2000 (9-Nitro-Camptothecin, 9-NC) in Patients With Soft-Tissue Sarcomas Completed NCT00005874 Phase 2 rubitecan
8 A Phase II Trial of Gemcitabine and Docetaxel in Patients With Unresectable Leiomyosarcoma Completed NCT00004066 Phase 2 docetaxel;gemcitabine hydrochloride
9 MMT 98 Study For Metastatic Disease Rhabdomyosarcoma And Other Malignant Soft Tissue Sarcoma Of Childhood Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
10 A Pilot Phase I/II Trial of Enteral Wallstents for Colonic Obstruction in the Setting of Malignancy Completed NCT00004911 Phase 1, Phase 2
11 A Pilot Phase I/II Trial of Enteral Wallstents for Duodenal Obstruction in the Setting of Malignancy Completed NCT00004910 Phase 1, Phase 2
12 Octreotide for Palliation of Inoperable Bowel Obstruction: A Phase II Study Completed NCT00004895 Phase 2 octreotide acetate
13 Dose Finding and Phase II Study of STI 571 in Advanced Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
14 Pilot Study of Intraperitoneal (IP) Therapy With Cisplatin or Carboplatin and Floxuridine (FUdR) as Consolidation for Ovarian and Gastrointestinal Malignancies Completed NCT00005049 Phase 2 carboplatin;cisplatin;floxuridine
15 Phase II Study on ET-743 in Advanced Soft Tissue Sarcomas of the Adult Completed NCT00003939 Phase 2 trabectedin
16 Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms Active, not recruiting NCT00445965 Phase 2
17 A Phase I Study of Intraperitoneal Oxaliplatin Alone and in Combination With Intraperitoneal Floxuridine and Leucovorin in Patients With Advanced Metastatic Cancer Confined to the Peritoneal Cavity Completed NCT00005860 Phase 1 floxuridine;leucovorin calcium;oxaliplatin
18 Phase I Clinical Study of Every Three Week Irinotecan With Oral Capecitabine Given Twice Daily for Two Weeks Out of Three in Patients With Gastrointestinal and Other Solid Malignancies Completed NCT00003867 Phase 1 capecitabine;irinotecan hydrochloride
19 A Phase I Clinical Trial To Assess The Safety And Efficacy Of Intraperitoneal PV701 Administrations In Patients With Advanced Or Recurrent Malignancy Largely Confined To The Peritoneal Cavity Completed NCT00055705 Phase 1
20 Pilot Study of Oxaliplatin in Combination With Capecitabine in Adult Cancer Patients Completed NCT00019773 Phase 1 capecitabine;oxaliplatin
21 Phase I Pharmacokinetic Trial of Thalidomide and Docetaxel: A Regimen Based on Anti-Angiogenic Therapeutic Principles Completed NCT00049296 Phase 1 docetaxel;thalidomide
22 A Pharmacogenetic-Based Phase I Trial of Irinotecan, 5-Fluorouracil, and Leucovorin (FOLFIRI) in Patients With Advanced Gastrointestinal Cancer Completed NCT00654160 Phase 1 fluorouracil;irinotecan hydrochloride;leucovorin calcium
23 Improving Palliative Care for Patients With Cancer Completed NCT00253383
24 Prospective, Randomized Trial Comparing Heparin and Minocycline-EDTA Flush for the Prevention of Catheter-Related Infections and Occlusions Withdrawn NCT00378781 Heparin;Minocycline-EDTA

Search NIH Clinical Center for Small Intestine Leiomyosarcoma

Genetic Tests for Small Intestine Leiomyosarcoma

Anatomical Context for Small Intestine Leiomyosarcoma

MalaCards organs/tissues related to Small Intestine Leiomyosarcoma:

40
Small Intestine, Smooth Muscle, Liver

Publications for Small Intestine Leiomyosarcoma

Articles related to Small Intestine Leiomyosarcoma:

# Title Authors PMID Year
1
Laparoscopic resection of small bowel sarcoma. 61
23752024 2013
2
[Application of digital subtraction angiography and interventional treatment in gastrointestinal arterial hemorrhage]. 61
19434532 2009
3
[Imaging evaluation and interventional therapy of hepatic metastases from small intestinal leiomyosarcoma]. 61
11782295 2001
4
[Myogenic tumors of the digestive tract]. 61
10566204 1999
5
[Chemoembolization of hepatic metastases of small intestine leiomyosarcoma. 2 cases]. 61
9161505 1997

Variations for Small Intestine Leiomyosarcoma

Expression for Small Intestine Leiomyosarcoma

Search GEO for disease gene expression data for Small Intestine Leiomyosarcoma.

Pathways for Small Intestine Leiomyosarcoma

GO Terms for Small Intestine Leiomyosarcoma

Biological processes related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemopoiesis GO:0030097 8.62 KIT CD34

Sources for Small Intestine Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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