MCID: SML014
MIFTS: 39

Small Intestine Leiomyosarcoma

Categories: Gastrointestinal diseases, Rare diseases, Cancer diseases, Muscle diseases

Aliases & Classifications for Small Intestine Leiomyosarcoma

MalaCards integrated aliases for Small Intestine Leiomyosarcoma:

Name: Small Intestine Leiomyosarcoma 12 15 73
Smooth Muscle Connective Tissue Tumor 12
Leiomyosarcoma of the Small Bowel 12
Leiomyosarcoma of Small Intestine 59

Classifications:



External Ids:

Disease Ontology 12 DOID:5271
NCIt 50 C7085
Orphanet 59 ORPHA104076
ICD10 via Orphanet 34 C17.1 C17.2 C17.3 more
UMLS via Orphanet 74 C0920305
UMLS 73 C0920305

Summaries for Small Intestine Leiomyosarcoma

Disease Ontology : 12 A small intestine sarcoma that affects the involuntary smooth muscles of the small intestines.

MalaCards based summary : Small Intestine Leiomyosarcoma, also known as smooth muscle connective tissue tumor, is related to leiomyosarcoma and malignant anus melanoma. An important gene associated with Small Intestine Leiomyosarcoma is IHH (Indian Hedgehog), and among its related pathways/superpathways are Innate Lymphoid Cell Differentiation Pathways and C-MYB transcription factor network. The drugs Oxaliplatin and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include small intestine, smooth muscle and breast, and related phenotypes are Decreased human papilloma virus 16 (HPV16) pseudovirus infection and cardiovascular system

Related Diseases for Small Intestine Leiomyosarcoma

Diseases related to Small Intestine Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 29.5 IGF2 KIT
2 malignant anus melanoma 10.4 ADAM17 KIT
3 osteochondrosis 10.2 IGF2 IHH
4 congenital mesoblastic nephroma 10.2 IGF2 KIT
5 endocrine pancreas disease 10.0 GCG IGF2
6 ovarian brenner tumor 10.0 ANO1 KIT
7 clear cell sarcoma 10.0 IGF2 KIT
8 pancreas disease 10.0 GCG IGF2
9 gallbladder leiomyoma 10.0 CD34 KIT
10 lung leiomyosarcoma 10.0 CD34 KIT
11 deep leiomyoma 9.9 CD34 KIT
12 extracutaneous mastocytoma 9.9 CD34 KIT
13 gallbladder sarcoma 9.9 CD34 KIT
14 prostate leiomyosarcoma 9.9 CD34 KIT
15 diffuse cutaneous mastocytosis 9.9 CD34 KIT
16 sarcomatoid squamous cell skin carcinoma 9.9 CD34 KIT
17 breast angiosarcoma 9.9 CD34 KIT
18 plexiform schwannoma 9.9 CD34 KIT
19 conventional fibrosarcoma 9.9 CD34 KIT
20 senile angioma 9.9 CD34 KIT
21 angiomyoma 9.9 CD34 KIT
22 spindle cell liposarcoma 9.9 CD34 KIT
23 mesenchymal cell neoplasm 9.8 CD34 KIT
24 spindle cell synovial sarcoma 9.8 CD34 KIT
25 connective tissue cancer 9.7 CD34 KIT
26 periosteal osteogenic sarcoma 9.7 CD34 IGF2
27 organ system benign neoplasm 9.7 CD34 KIT
28 leukocyte disease 9.7 CD34 KIT
29 dermatofibrosarcoma protuberans 9.6 CD34 KIT
30 cell type cancer 9.4 CD34 KIT
31 muscle cancer 9.3 CD34 IGF2 KIT
32 leiomyoma 9.3 CD34 IGF2 KIT
33 liver leiomyoma 9.2 ANO1 CD34 KIT
34 meninges sarcoma 9.2 CD34 GCG IGF2
35 gastrointestinal system cancer 8.8 ADAM17 CD34 IGF2 KIT
36 gastric leiomyosarcoma 8.6 ANO1 CD34 IGF2 KIT
37 gastrointestinal stromal tumor 8.6 ANO1 CD34 IGF2 KIT
38 ewing sarcoma 8.5 CD34 IGF2 KIT
39 small intestinal sarcoma 7.0 ADAM17 ANO1 CD34 GCG IGF2 IHH

Graphical network of the top 20 diseases related to Small Intestine Leiomyosarcoma:



Diseases related to Small Intestine Leiomyosarcoma

Symptoms & Phenotypes for Small Intestine Leiomyosarcoma

GenomeRNAi Phenotypes related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human papilloma virus 16 (HPV16) pseudovirus infection GR00306-A 8.92 GCG IGF2 IHH KIT

MGI Mouse Phenotypes related to Small Intestine Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 IGF2 IHH KIT ADAM17 ANO1
2 digestive/alimentary MP:0005381 9.77 IGF2 IHH KIT ADAM17 ANO1
3 integument MP:0010771 9.72 IGF2 KIT ADAM17 ANO1 CD34
4 limbs/digits/tail MP:0005371 9.56 IGF2 IHH KIT ADAM17
5 muscle MP:0005369 9.55 IGF2 IHH KIT ADAM17 ANO1
6 respiratory system MP:0005388 9.35 IHH KIT ADAM17 ANO1 IGF2
7 skeleton MP:0005390 9.02 IGF2 IHH KIT ADAM17 ANO1

Drugs & Therapeutics for Small Intestine Leiomyosarcoma

Drugs for Small Intestine Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 112)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 4,Phase 1 61825-94-3 5310940 9887054 43805 6857599
2 Liver Extracts Phase 4,Phase 3,Phase 1,Not Applicable
3 Cola Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
4
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
5
Ondansetron Approved Phase 3 99614-02-5 4595
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
7
Cyproheptadine Approved Phase 3 129-03-3 2913
8
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
9 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
10 Dexamethasone acetate Phase 3,Phase 2 1177-87-3
11 Analgesics Phase 3
12 glucocorticoids Phase 3
13
protease inhibitors Phase 3
14 Central Nervous System Depressants Phase 3
15 Adjuvants, Anesthesia Phase 3
16 Serotonin Agents Phase 3
17 Serotonin Antagonists Phase 3
18 Gastrointestinal Agents Phase 3,Phase 2
19 Narcotics Phase 3
20 Neurotransmitter Agents Phase 3
21 Analgesics, Opioid Phase 3
22 HIV Protease Inhibitors Phase 3
23 Anesthetics Phase 3
24 Hormone Antagonists Phase 3
25 Anesthetics, General Phase 3
26 Dermatologic Agents Phase 3,Not Applicable
27 Anesthetics, Intravenous Phase 3
28 Tranquilizing Agents Phase 3
29 Hormones Phase 3
30 Anti-Anxiety Agents Phase 3
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
32 Peripheral Nervous System Agents Phase 3
33 Antiemetics Phase 3
34 Anti-Inflammatory Agents Phase 3
35 Antipruritics Phase 3
36 Antipsychotic Agents Phase 3
37 Psychotropic Drugs Phase 3
38 BB 1101 Phase 3,Phase 2
39 Autonomic Agents Phase 3
40 Antineoplastic Agents, Hormonal Phase 3,Phase 2
41
Histamine Phosphate Phase 3 51-74-1 65513
42 Histamine Antagonists Phase 3
43 Histamine H1 Antagonists Phase 3
44 Anti-Allergic Agents Phase 3
45
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
46
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
47
Gemcitabine Approved Phase 2 95058-81-4 60750
48
Lenograstim Approved, Investigational Phase 2 135968-09-1
49
Etoposide Approved Phase 2 33419-42-0 36462
50
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Relationship Between Platinum Levels in the Blood and Neurotoxicity in Patients Who Are Receiving Oxaliplatin for Gastrointestinal Cancer Unknown status NCT00274885 Phase 4 oxaliplatin
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Ondansetron With or Without Dexamethasone to Prevent Vomiting in Patients Receiving Radiation Therapy to the Upper Abdomen Completed NCT00016380 Phase 3 dexamethasone;ondansetron
4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
6 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
7 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
8 Gemcitabine, Docetaxel, and Filgrastim in Treating Patients With Recurrent or Persistent Leiomyosarcoma or Soft Tissue Sarcoma Completed NCT00004066 Phase 2 docetaxel;gemcitabine hydrochloride
9 Nitrocamptothecin in Treating Patients With Soft Tissue Sarcomas Completed NCT00005874 Phase 2 rubitecan
10 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
11 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
12 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
13 Endoscopic Placement of Metal Stent in Patients With Cancer-Related Bowel Obstruction Completed NCT00004911 Phase 1, Phase 2
14 Endoscopic Placement of Metal Stents in Treating Patients With Cancer- Related Duodenal Obstruction Completed NCT00004910 Phase 1, Phase 2
15 Octreotide as Palliative Therapy for Cancer-Related Bowel Obstruction That Cannot Be Removed by Surgery Completed NCT00004895 Phase 2 octreotide acetate
16 Combination Chemotherapy in Treating Patients With Stage III Ovarian Epithelial Cancer or Gastrointestinal Cancer Completed NCT00005049 Phase 2 carboplatin;cisplatin;floxuridine
17 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
18 Irinotecan and Capecitabine in Treating Patients With Solid Tumors Unknown status NCT00003867 Phase 1 capecitabine;irinotecan hydrochloride
19 Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer Completed NCT00397384 Phase 1 cetuximab;erlotinib hydrochloride
20 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
21 Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Gastrointestinal Cancer Completed NCT00654160 Phase 1 fluorouracil;irinotecan hydrochloride;leucovorin calcium
22 Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum Completed NCT00005860 Phase 1 floxuridine;leucovorin calcium;oxaliplatin
23 PV701 in Treating Patients With Advanced or Recurrent Peritoneal Cancer Completed NCT00055705 Phase 1
24 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
25 Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer Completed NCT00019773 Phase 1 capecitabine;oxaliplatin
26 Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients Completed NCT00253383 Not Applicable
27 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
28 EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer Terminated NCT00087191 Not Applicable EF5;motexafin lutetium
29 Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection Withdrawn NCT00378781 Not Applicable Heparin;Minocycline-EDTA

Search NIH Clinical Center for Small Intestine Leiomyosarcoma

Genetic Tests for Small Intestine Leiomyosarcoma

Anatomical Context for Small Intestine Leiomyosarcoma

MalaCards organs/tissues related to Small Intestine Leiomyosarcoma:

41
Small Intestine, Smooth Muscle, Breast, Lung, Appendix, Liver

Publications for Small Intestine Leiomyosarcoma

Articles related to Small Intestine Leiomyosarcoma:

# Title Authors Year
1
A leiomyosarcoma of the small bowels causing obscure gastrointestinal bleeding diagnosed by capsule endoscopy. ( 21409947 )
2010

Variations for Small Intestine Leiomyosarcoma

Expression for Small Intestine Leiomyosarcoma

Search GEO for disease gene expression data for Small Intestine Leiomyosarcoma.

Pathways for Small Intestine Leiomyosarcoma

Pathways related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.27 CD34 KIT
2 11.21 CD34 KIT
3 11.13 CD34 KIT
4 10.97 IGF2 IHH
5 10.68 CD34 KIT
6 10.35 IGF2 KIT

GO Terms for Small Intestine Leiomyosarcoma

Cellular components related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.17 ADAM17 ANO1 CD34 GCG IGF2 IHH
2 apical plasma membrane GO:0016324 9.13 ADAM17 ANO1 CD34

Biological processes related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.67 ANO1 IGF2 IHH KIT
2 hemopoiesis GO:0030097 9.4 CD34 KIT
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.32 IGF2 KIT
4 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.26 ANO1 GCG
5 negative regulation of apoptotic process GO:0043066 9.26 GCG IGF2 IHH KIT
6 cell motility GO:0048870 9.16 ADAM17 CD34
7 positive regulation of cell proliferation GO:0008284 8.92 ADAM17 IGF2 IHH KIT

Sources for Small Intestine Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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