MCID: SML004
MIFTS: 26

Small Intestine Neuroendocrine Neoplasm

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Small Intestine Neuroendocrine Neoplasm

MalaCards integrated aliases for Small Intestine Neuroendocrine Neoplasm:

Name: Small Intestine Neuroendocrine Neoplasm 12 15
Small Intestine Neuroendocrine Tumor 12 17
Neuroendocrine Neoplasm of the Small Intestine 58
Neuroendocrine Tumor of the Small Intestine 58
Small Intestinal Neuroendocrine Neoplasm 70
Neuroendocrine Tumor of Small Bowel 58
Net of the Small Intestine 58

Classifications:

Orphanet: 58  
Rare gastroenterological diseases
Rare endocrine diseases


External Ids:

Disease Ontology 12 DOID:4434
NCIt 50 C5803
Orphanet 58 ORPHA423975
UMLS 70 C1336005

Summaries for Small Intestine Neuroendocrine Neoplasm

MalaCards based summary : Small Intestine Neuroendocrine Neoplasm, also known as small intestine neuroendocrine tumor, is related to carcinoid syndrome and neuroendocrine tumor. An important gene associated with Small Intestine Neuroendocrine Neoplasm is HOOK3 (Hook Microtubule Tethering Protein 3), and among its related pathways/superpathways is Transcriptional misregulation in cancer. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include small intestine and liver.

Related Diseases for Small Intestine Neuroendocrine Neoplasm

Diseases related to Small Intestine Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 carcinoid syndrome 30.6 SST MEN1
2 neuroendocrine tumor 30.4 SST MEN1 CDKN1B
3 hereditary neuroendocrine tumor of small intestine 11.4
4 familial isolated pituitary adenoma 10.3 MEN1 CDKN1B
5 gastrointestinal neuroendocrine benign tumor 10.2 SST MEN1
6 non-functioning pancreatic endocrine tumor 10.2 SST MEN1
7 duodenal gastrinoma 10.2 SST MEN1
8 gastrinoma 10.2 SST MEN1
9 gastric neuroendocrine neoplasm 10.2 SST MEN1
10 multiple endocrine neoplasia, type iv 10.2 MEN1 CDKN1B
11 endocrine pancreas disease 10.2 SST MEN1
12 duodenal somatostatinoma 10.2 SST MEN1
13 somatostatinoma 10.2 SST MEN1
14 pancreatic gastrinoma 10.2 SST MEN1
15 pituitary infarct 10.2 SST MEN1
16 gastrointestinal neuroendocrine tumor 10.2 SST MEN1
17 carcinoid tumors, intestinal 10.2 SST MEN1
18 pancreatic cholera 10.2 SST MEN1
19 hormone producing pituitary cancer 10.2 SST MEN1
20 pulmonary neuroendocrine tumor 10.2 SST MEN1
21 pituitary apoplexy 10.2 SST MEN1
22 hyperpituitarism 10.1 SST MEN1
23 pituitary adenoma 1, multiple types 10.1 SST MEN1
24 serotonin syndrome 10.1 SST MEN1
25 pancreatic endocrine carcinoma 10.1 SST MEN1
26 duodenum cancer 10.1 SST MEN1
27 ewing sarcoma 10.1
28 neuroendocrine carcinoma 10.1
29 duodenum disease 10.1 SST MEN1
30 pituitary carcinoma 10.1 SST MEN1
31 pituitary tumors 10.1 SST MEN1
32 vipoma 10.1 SST MEN1
33 zollinger-ellison syndrome 10.1 SST MEN1
34 acth-secreting pituitary adenoma 10.1 SST MEN1 CDKN1B
35 pituitary adenoma 10.1 SST MEN1 CDKN1B
36 carney complex variant 10.1 SST MEN1 CDKN1B
37 thyroid gland medullary carcinoma 10.0 SST MEN1
38 multiple endocrine neoplasia 10.0 SST MEN1 CDKN1B
39 multiple endocrine neoplasia, type i 10.0 SST MEN1 CDKN1B
40 pancreatic cystadenoma 10.0 SST MEN1
41 functioning pituitary adenoma 10.0 SST MEN1
42 growth hormone secreting pituitary adenoma 9.9 SST MEN1
43 familial hypocalciuric hypercalcemia 9.9 MEN1 CDKN1B
44 small intestine benign neoplasm 9.0 SST PNMA2 NONO MLF1 MIR3137 MEN1

Graphical network of the top 20 diseases related to Small Intestine Neuroendocrine Neoplasm:



Diseases related to Small Intestine Neuroendocrine Neoplasm

Symptoms & Phenotypes for Small Intestine Neuroendocrine Neoplasm

Drugs & Therapeutics for Small Intestine Neuroendocrine Neoplasm

Drugs for Small Intestine Neuroendocrine Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Volumetric Imaging Follow up of Patients With Liver Metastases of Small Intestinal Neuroendocrine Tumors (NETs). Unknown status NCT03689231
2 Prophylactic Cholecystectomy is Not Mandatory in Patients Candidate to the Resection for Small Intestine Neuroendocrine Neoplasms: a Propensity Score-matched and Cost-minimization Analysis Completed NCT04780737
3 Diagnostic Performances of Urine and Plasma 5-hydroxyindolacetic Acid (5HIAA) Values in Patients With Small-intestine Neuroendocrine Tumors Recruiting NCT02826928
4 Resection of the Primary Tumor vs no Resection in Asymptomatic Patients With Unresectable Synchronous Liver Metastases From siNEN Recruiting NCT03442959

Search NIH Clinical Center for Small Intestine Neuroendocrine Neoplasm

Genetic Tests for Small Intestine Neuroendocrine Neoplasm

Anatomical Context for Small Intestine Neuroendocrine Neoplasm

MalaCards organs/tissues related to Small Intestine Neuroendocrine Neoplasm:

40
Small Intestine, Liver

Publications for Small Intestine Neuroendocrine Neoplasm

Articles related to Small Intestine Neuroendocrine Neoplasm:

(show all 15)
# Title Authors PMID Year
1
First Ex Vivo Results of Beta-Radioguided Surgery in Small Intestine Neuroendocrine Tumors with Y-90-DOTATOC. 61
33601932 2021
2
Current practice in approaching controversial diagnostic and therapeutic topics in gastroenteropancreatic neuroendocrine neoplasm management. Belgian multidisciplinary expert discussion based on a modified Delphi method. 61
33321023 2020
3
Assessment of serotonin concentration in patients with a small-intestine neuroendocrine neoplasm and carcinoid syndrome treated with somatostatin analogues. 61
32643913 2020
4
Evaluation of 5-hydroxyindoloacetic acid excretion in urine in patients with small intestine neuroendocrine neoplasm and carcinoid syndrome treated with somatostatin analogues. 61
32304367 2019
5
ONCOGENE PANEL SEQUENCING ANALYSIS IDENTIFIES CANDIDATE ACTIONABLE GENES IN ADVANCED WELL-DIFFERENTIATED GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS. 61
30865533 2019
6
Transcriptional effects of 177Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice. 61
30895393 2019
7
Small Intestine Neuroendocrine Tumor in a Patient With MUTYH Adenomatous Polyposis-Case Report and SEER Analysis. 61
29843990 2018
8
Prognostic Utility of 24-Hour Urinary 5-HIAA Doubling Time in Patients With Neuroendocrine Tumors. 61
30084688 2018
9
Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu[Lu]-octreotate therapy. 61
29502008 2018
10
Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to 177Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine Tumor. 61
29331677 2018
11
Functional Defects From Endocrine Disease-Associated Mutations in HLXB9 and Its Interacting Partner, NONO. 61
29309627 2018
12
Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1. 61
28097640 2017
13
Genetic associations with neuroendocrine tumor risk: results from a genome-wide association study. 61
27492634 2016
14
Feasibility of Radio-Guided Surgery with ⁶⁸Gallium-DOTATATE in Patients with Gastro-Entero-Pancreatic Neuroendocrine Tumors. 61
26350374 2015
15
Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines. 61
19634160 2009

Variations for Small Intestine Neuroendocrine Neoplasm

Expression for Small Intestine Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Small Intestine Neuroendocrine Neoplasm.

Pathways for Small Intestine Neuroendocrine Neoplasm

Pathways related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.21 MLF1 MEN1 FEV CDKN1B

GO Terms for Small Intestine Neuroendocrine Neoplasm

Biological processes related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to amino acid GO:0043200 9.16 SST CDKN1B
2 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 8.96 MEN1 CDKN1B
3 early endosome to late endosome transport GO:0045022 8.62 KIF16B HOOK3

Sources for Small Intestine Neuroendocrine Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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