Small Intestine Neuroendocrine Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Small Intestine Neuroendocrine Neoplasm

MalaCards integrated aliases for Small Intestine Neuroendocrine Neoplasm:

Name: Small Intestine Neuroendocrine Neoplasm ¹² ¹⁵

Small Intestine Neuroendocrine Tumor ¹² ¹⁷

Small Intestinal Neuroendocrine Neoplasm ⁷⁴

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4434

NCIt ⁵¹ C5803

EFO ¹⁷ EFO_1001928

UMLS ⁷⁴ C1336005

Sources

Summaries for Small Intestine Neuroendocrine Neoplasm

MalaCards based summary : Small Intestine Neuroendocrine Neoplasm, also known as small intestine neuroendocrine tumor, is related to neuroendocrine tumor and intestinal neuroendocrine benign tumor. An important gene associated with Small Intestine Neuroendocrine Neoplasm is BCAT1 (Branched Chain Amino Acid Transaminase 1), and among its related pathways/superpathways are Circadian rythm related genes and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include small intestine, and related phenotypes are behavior/neurological and homeostasis/metabolism

Sources

Related Diseases for Small Intestine Neuroendocrine Neoplasm

Diseases related to Small Intestine Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	neuroendocrine tumor	10.1
2	intestinal neuroendocrine benign tumor	10.1	BCAT1 MNX1 SSTR1
3	oncogenic osteomalacia	10.0	SSTR1 SSTR3 SSTR5
4	hormone producing pituitary cancer	10.0	SSTR2 SSTR5
5	acromegaly	9.9	SSTR1 SSTR2 SSTR5
6	thyroid carcinoma, familial medullary	9.9	SSTR1 SSTR2 SSTR5
7	pancreatic endocrine carcinoma	9.8	SSTR2 SSTR5
8	pituitary adenoma, prolactin-secreting	9.8	SSTR1 SSTR2 SSTR3 SSTR5

Graphical network of the top 20 diseases related to Small Intestine Neuroendocrine Neoplasm:

Sources

Symptoms & Phenotypes for Small Intestine Neuroendocrine Neoplasm

MGI Mouse Phenotypes related to Small Intestine Neuroendocrine Neoplasm:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.56	ADORA2A APOE MNX1 NONO SSTR1 SSTR2
2	homeostasis/metabolism	MP:0005376	9.4	ADORA2A APOE BNIP3 GADD45A MNX1 MUTYH

Sources

Drugs & Therapeutics for Small Intestine Neuroendocrine Neoplasm

Drugs for Small Intestine Neuroendocrine Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Liver Extracts

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Diagnostic Performances of Urine and Plasma 5-hydroxyindolacetic Acid (5HIAA) Values in Patients With Small-intestine Neuroendocrine Tumors	Recruiting	NCT02826928	Not Applicable
2	Resection of the Primary Tumor vs no Resection in Asymptomatic Patients With Unresectable Synchronous Liver Metastases From siNEN	Recruiting	NCT03442959

Search NIH Clinical Center for Small Intestine Neuroendocrine Neoplasm

Sources

Genetic Tests for Small Intestine Neuroendocrine Neoplasm

Sources

Anatomical Context for Small Intestine Neuroendocrine Neoplasm

MalaCards organs/tissues related to Small Intestine Neuroendocrine Neoplasm:

⁴²

Small Intestine

Sources

Publications for Small Intestine Neuroendocrine Neoplasm

Articles related to Small Intestine Neuroendocrine Neoplasm:

#	Title	Authors	Year
1	Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to<sup>177</sup>Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine Tumor. ( 29331677 )	Montelius M....Forssell-Aronsson E.	2018
2	Small Intestine Neuroendocrine Tumor in a Patient With MUTYH Adenomatous Polyposis-Case Report and SEER Analysis. ( 29843990 )	Weidner T.K....Mishra N.	2018
3	Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu[Lu]-octreotate therapy. ( 29502008 )	Spetz J...Forssell-Aronsson E	2018
4	Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1. ( 28097640 )	Dalmo J...Forssell-Aronsson E	2017
5	Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines. ( 19634160 )	Drozdov I....Modlin I.M.	2009

Sources

Genes for Small Intestine Neuroendocrine Neoplasm

Genes related to Small Intestine Neuroendocrine Neoplasm (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	BCAT1	Branched Chain Amino Acid Transaminase 1	Protein Coding	15.58	DISEASES inferred ¹⁵
2	MNX1	Motor Neuron And Pancreas Homeobox 1	Protein Coding	15.55	DISEASES inferred ¹⁵
3	SSTR1	Somatostatin Receptor 1	Protein Coding	15.33	DISEASES inferred ¹⁵
4	NONO	Non-POU Domain Containing Octamer Binding	Protein Coding	14.87	DISEASES inferred ¹⁵
5	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	14.55	DISEASES inferred ¹⁵
6	MUTYH	MutY DNA Glycosylase	Protein Coding	14.45	DISEASES inferred ¹⁵
7	SSTR3	Somatostatin Receptor 3	Protein Coding	14.44	DISEASES inferred ¹⁵
8	SSTR5	Somatostatin Receptor 5	Protein Coding	14.33	DISEASES inferred ¹⁵
9	ADORA2A	Adenosine A2a Receptor	Protein Coding	14.21	DISEASES inferred ¹⁵
10	SSTR2	Somatostatin Receptor 2	Protein Coding	14.19	DISEASES inferred ¹⁵
11	APOE	Apolipoprotein E	Protein Coding	13.74	DISEASES inferred ¹⁵
12	TPH1	Tryptophan Hydroxylase 1	Protein Coding	13.18	DISEASES inferred ¹⁵
13	BNIP3L	BCL2 Interacting Protein 3 Like	Protein Coding	5.4	DISEASES inferred ¹⁵
14	BNIP3	BCL2 Interacting Protein 3	Protein Coding	4.66	DISEASES inferred ¹⁵
15	SSTR4	Somatostatin Receptor 4	Protein Coding	4.47	DISEASES inferred ¹⁵

Sources

Variations for Small Intestine Neuroendocrine Neoplasm

Sources

Expression for Small Intestine Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Small Intestine Neuroendocrine Neoplasm.

Sources

Pathways for Small Intestine Neuroendocrine Neoplasm

Pathways related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Circadian rythm related genes ¹	11.75	ADORA2A NONO TPH1
2	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.34	SSTR1 SSTR2 TPH1
3	cAMP signaling pathway ³⁸	11.25	ADORA2A SSTR1 SSTR2 SSTR5
4	Photodynamic therapy-induced HIF-1 survival signaling ¹	10.72	BNIP3 BNIP3L

Sources

GO Terms for Small Intestine Neuroendocrine Neoplasm

Cellular components related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.43	ADORA2A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
2	mitochondrial envelope	GO:0005740	8.62	BNIP3 BNIP3L

Biological processes related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell proliferation	GO:0008285	9.85	ADORA2A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
2	cerebellum development	GO:0021549	9.65	SSTR1 SSTR2 SSTR3
3	neuropeptide signaling pathway	GO:0007218	9.65	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
4	forebrain development	GO:0030900	9.62	SSTR1 SSTR2 SSTR3 SSTR4
5	cellular response to estradiol stimulus	GO:0071392	9.61	SSTR1 SSTR2 SSTR3
6	response to starvation	GO:0042594	9.58	SSTR1 SSTR2 SSTR3
7	positive regulation of macroautophagy	GO:0016239	9.56	BNIP3 BNIP3L
8	synaptic transmission, cholinergic	GO:0007271	9.55	ADORA2A APOE
9	vasodilation	GO:0042311	9.54	ADORA2A APOE
10	mitochondrial outer membrane permeabilization	GO:0097345	9.52	BNIP3 BNIP3L
11	negative regulation of mitochondrial membrane potential	GO:0010917	9.51	BNIP3 BNIP3L
12	mitochondrial protein catabolic process	GO:0035694	9.49	BNIP3 BNIP3L
13	cellular response to glucocorticoid stimulus	GO:0071385	9.46	SSTR2 SSTR3 SSTR4 SSTR5
14	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:0007187	9.35	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
15	somatostatin signaling pathway	GO:0038170	9.02	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
16	G protein-coupled receptor signaling pathway	GO:0007186	10	ADORA2A APOE SSTR1 SSTR2 SSTR3 SSTR4

Molecular functions related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.73	ADORA2A APOE BCAT1 BNIP3 BNIP3L NONO
2	G protein-coupled receptor activity	GO:0004930	9.63	ADORA2A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
3	protein heterodimerization activity	GO:0046982	9.62	ADORA2A BNIP3 BNIP3L GADD45A
4	neuropeptide binding	GO:0042923	9.35	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
5	somatostatin receptor activity	GO:0004994	9.02	SSTR1 SSTR2 SSTR3 SSTR4 SSTR5

Sources

Sources for Small Intestine Neuroendocrine Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia