MCID: SML004
MIFTS: 31

Small Intestine Neuroendocrine Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Small Intestine Neuroendocrine Neoplasm

MalaCards integrated aliases for Small Intestine Neuroendocrine Neoplasm:

Name: Small Intestine Neuroendocrine Neoplasm 12 15
Small Intestine Neuroendocrine Tumor 12 17
Small Intestinal Neuroendocrine Neoplasm 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4434
NCIt 51 C5803
UMLS 74 C1336005

Summaries for Small Intestine Neuroendocrine Neoplasm

MalaCards based summary : Small Intestine Neuroendocrine Neoplasm, also known as small intestine neuroendocrine tumor, is related to neuroendocrine tumor and intestinal neuroendocrine benign tumor. An important gene associated with Small Intestine Neuroendocrine Neoplasm is BCAT1 (Branched Chain Amino Acid Transaminase 1), and among its related pathways/superpathways are Circadian rythm related genes and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and pituitary, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Small Intestine Neuroendocrine Neoplasm

Diseases related to Small Intestine Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 10.1
2 intestinal neuroendocrine benign tumor 10.1 BCAT1 MNX1 SSTR1
3 oncogenic osteomalacia 10.0 SSTR1 SSTR3 SSTR5
4 hormone producing pituitary cancer 10.0 SSTR2 SSTR5
5 acromegaly 9.9 SSTR1 SSTR2 SSTR5
6 thyroid carcinoma, familial medullary 9.9 SSTR1 SSTR2 SSTR5
7 pancreatic endocrine carcinoma 9.8 SSTR2 SSTR5
8 pituitary adenoma, prolactin-secreting 9.8 SSTR1 SSTR2 SSTR3 SSTR5

Graphical network of the top 20 diseases related to Small Intestine Neuroendocrine Neoplasm:



Diseases related to Small Intestine Neuroendocrine Neoplasm

Symptoms & Phenotypes for Small Intestine Neuroendocrine Neoplasm

MGI Mouse Phenotypes related to Small Intestine Neuroendocrine Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 ADORA2A APOE MNX1 NONO SSTR1 SSTR2
2 homeostasis/metabolism MP:0005376 9.4 ADORA2A APOE BNIP3 GADD45A MNX1 MUTYH

Drugs & Therapeutics for Small Intestine Neuroendocrine Neoplasm

Drugs for Small Intestine Neuroendocrine Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnostic Performances of Urine and Plasma 5-hydroxyindolacetic Acid (5HIAA) Values in Patients With Small-intestine Neuroendocrine Tumors Recruiting NCT02826928 Not Applicable
2 Resection of the Primary Tumor vs no Resection in Asymptomatic Patients With Unresectable Synchronous Liver Metastases From siNEN Recruiting NCT03442959
3 PreOPerative Imaging of NeuroEndocrine Tumors Active, not recruiting NCT03958188

Search NIH Clinical Center for Small Intestine Neuroendocrine Neoplasm

Genetic Tests for Small Intestine Neuroendocrine Neoplasm

Anatomical Context for Small Intestine Neuroendocrine Neoplasm

MalaCards organs/tissues related to Small Intestine Neuroendocrine Neoplasm:

42
Small Intestine, Liver, Pituitary, Thyroid

Publications for Small Intestine Neuroendocrine Neoplasm

Articles related to Small Intestine Neuroendocrine Neoplasm:

# Title Authors Year
1
Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to 177Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine Tumor. ( 29331677 )
2018
2
Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu[Lu]-octreotate therapy. ( 29502008 )
2018
3
Small Intestine Neuroendocrine Tumor in a Patient With MUTYH Adenomatous Polyposis-Case Report and SEER Analysis. ( 29843990 )
2018
4
Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1. ( 28097640 )
2017
5
Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines. ( 19634160 )
2009

Variations for Small Intestine Neuroendocrine Neoplasm

Expression for Small Intestine Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Small Intestine Neuroendocrine Neoplasm.

Pathways for Small Intestine Neuroendocrine Neoplasm

Pathways related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
2 11.34 SSTR1 SSTR2 TPH1
3 11.25 ADORA2A SSTR1 SSTR2 SSTR5
4 10.72 BNIP3 BNIP3L

GO Terms for Small Intestine Neuroendocrine Neoplasm

Cellular components related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.43 ADORA2A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
2 mitochondrial envelope GO:0005740 8.62 BNIP3 BNIP3L

Biological processes related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.85 ADORA2A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
2 cerebellum development GO:0021549 9.65 SSTR1 SSTR2 SSTR3
3 neuropeptide signaling pathway GO:0007218 9.65 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
4 forebrain development GO:0030900 9.62 SSTR1 SSTR2 SSTR3 SSTR4
5 cellular response to estradiol stimulus GO:0071392 9.61 SSTR1 SSTR2 SSTR3
6 response to starvation GO:0042594 9.58 SSTR1 SSTR2 SSTR3
7 positive regulation of macroautophagy GO:0016239 9.56 BNIP3 BNIP3L
8 synaptic transmission, cholinergic GO:0007271 9.55 ADORA2A APOE
9 vasodilation GO:0042311 9.54 ADORA2A APOE
10 mitochondrial outer membrane permeabilization GO:0097345 9.52 BNIP3 BNIP3L
11 negative regulation of mitochondrial membrane potential GO:0010917 9.51 BNIP3 BNIP3L
12 mitochondrial protein catabolic process GO:0035694 9.49 BNIP3 BNIP3L
13 cellular response to glucocorticoid stimulus GO:0071385 9.46 SSTR2 SSTR3 SSTR4 SSTR5
14 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.35 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
15 somatostatin signaling pathway GO:0038170 9.02 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
16 G protein-coupled receptor signaling pathway GO:0007186 10 ADORA2A APOE SSTR1 SSTR2 SSTR3 SSTR4

Molecular functions related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.73 ADORA2A APOE BCAT1 BNIP3 BNIP3L NONO
2 G protein-coupled receptor activity GO:0004930 9.63 ADORA2A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
3 protein heterodimerization activity GO:0046982 9.62 ADORA2A BNIP3 BNIP3L GADD45A
4 neuropeptide binding GO:0042923 9.35 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
5 somatostatin receptor activity GO:0004994 9.02 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5

Sources for Small Intestine Neuroendocrine Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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