MCID: SML004
MIFTS: 26

Small Intestine Neuroendocrine Neoplasm

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Small Intestine Neuroendocrine Neoplasm

MalaCards integrated aliases for Small Intestine Neuroendocrine Neoplasm:

Name: Small Intestine Neuroendocrine Neoplasm 12 15
Small Intestine Neuroendocrine Tumor 12 17
Neuroendocrine Neoplasm of the Small Intestine 59
Neuroendocrine Tumor of the Small Intestine 59
Small Intestinal Neuroendocrine Neoplasm 72
Neuroendocrine Tumor of Small Bowel 59
Net of the Small Intestine 59

Classifications:



External Ids:

Disease Ontology 12 DOID:4434
NCIt 50 C5803
Orphanet 59 ORPHA423975
UMLS 72 C1336005

Summaries for Small Intestine Neuroendocrine Neoplasm

MalaCards based summary : Small Intestine Neuroendocrine Neoplasm, also known as small intestine neuroendocrine tumor, is related to hereditary neuroendocrine tumor of small intestine and neuroendocrine tumor. An important gene associated with Small Intestine Neuroendocrine Neoplasm is SPINK5 (Serine Peptidase Inhibitor, Kazal Type 5), and among its related pathways/superpathways are Transcriptional misregulation in cancer and G-protein signaling N-RAS regulation pathway. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and lung.

Related Diseases for Small Intestine Neuroendocrine Neoplasm

Graphical network of the top 20 diseases related to Small Intestine Neuroendocrine Neoplasm:



Diseases related to Small Intestine Neuroendocrine Neoplasm

Symptoms & Phenotypes for Small Intestine Neuroendocrine Neoplasm

Drugs & Therapeutics for Small Intestine Neuroendocrine Neoplasm

Drugs for Small Intestine Neuroendocrine Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Resection of the Primary Tumor vs no Resection in Asymptomatic Patients With Unresectable Synchronous Liver Metastases From siNEN Recruiting NCT03442959

Search NIH Clinical Center for Small Intestine Neuroendocrine Neoplasm

Genetic Tests for Small Intestine Neuroendocrine Neoplasm

Anatomical Context for Small Intestine Neuroendocrine Neoplasm

MalaCards organs/tissues related to Small Intestine Neuroendocrine Neoplasm:

41
Small Intestine, Liver, Lung

Publications for Small Intestine Neuroendocrine Neoplasm

Articles related to Small Intestine Neuroendocrine Neoplasm:

(show all 11)
# Title Authors PMID Year
1
ONCOGENE PANEL SEQUENCING ANALYSIS IDENTIFIES CANDIDATE ACTIONABLE GENES IN ADVANCED WELL-DIFFERENTIATED GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS. 38
30865533 2019
2
Transcriptional effects of 177Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice. 38
30895393 2019
3
Small Intestine Neuroendocrine Tumor in a Patient With MUTYH Adenomatous Polyposis-Case Report and SEER Analysis. 38
29843990 2018
4
Prognostic Utility of 24-Hour Urinary 5-HIAA Doubling Time in Patients With Neuroendocrine Tumors. 38
30084688 2018
5
Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu[Lu]-octreotate therapy. 38
29502008 2018
6
Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to 177Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine Tumor. 38
29331677 2018
7
Functional Defects From Endocrine Disease-Associated Mutations in HLXB9 and Its Interacting Partner, NONO. 38
29309627 2018
8
Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1. 38
28097640 2017
9
Genetic associations with neuroendocrine tumor risk: results from a genome-wide association study. 38
27492634 2016
10
Feasibility of Radio-Guided Surgery with ⁶⁸Gallium-DOTATATE in Patients with Gastro-Entero-Pancreatic Neuroendocrine Tumors. 38
26350374 2015
11
Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines. 38
19634160 2009

Variations for Small Intestine Neuroendocrine Neoplasm

Expression for Small Intestine Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Small Intestine Neuroendocrine Neoplasm.

Pathways for Small Intestine Neuroendocrine Neoplasm

Pathways related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.53 SMAD1 MLF1
2
Show member pathways
11.11 DCHS1 CDH19
3 10.94 DCHS1 CDH19
4 10.71 DCHS1 CDH19

GO Terms for Small Intestine Neuroendocrine Neoplasm

Biological processes related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.16 DCHS1 CDH19
2 cell-cell adhesion GO:0098609 8.96 DCHS1 CDH19
3 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 8.62 DCHS1 CDH19

Sources for Small Intestine Neuroendocrine Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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