Small Intestine Neuroendocrine Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Small Intestine Neuroendocrine Neoplasm

MalaCards integrated aliases for Small Intestine Neuroendocrine Neoplasm:

Name: Small Intestine Neuroendocrine Neoplasm ¹² ¹⁵

Small Intestine Neuroendocrine Tumor ¹² ¹⁷

Neuroendocrine Neoplasm of the Small Intestine ⁵⁸

Neuroendocrine Tumor of the Small Intestine ⁵⁸

Small Intestinal Neuroendocrine Neoplasm ⁷⁰

Neuroendocrine Tumor of Small Bowel ⁵⁸

Net of the Small Intestine ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Gastrointestinal diseases Endocrine diseases Neuronal diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare gastroenterological diseases

Rare endocrine diseases

External Ids:

Disease Ontology ¹² DOID:4434

NCIt ⁵⁰ C5803

Orphanet ⁵⁸ ORPHA423975

EFO ¹⁷ EFO_1001928

UMLS ⁷⁰ C1336005

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Summaries for Small Intestine Neuroendocrine Neoplasm

MalaCards based summary : Small Intestine Neuroendocrine Neoplasm, also known as small intestine neuroendocrine tumor, is related to carcinoid syndrome and neuroendocrine tumor. An important gene associated with Small Intestine Neuroendocrine Neoplasm is HOOK3 (Hook Microtubule Tethering Protein 3), and among its related pathways/superpathways is Transcriptional misregulation in cancer. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include small intestine and liver.

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Related Diseases for Small Intestine Neuroendocrine Neoplasm

Diseases related to Small Intestine Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)

#	Related Disease	Score	Top Affiliating Genes
1	carcinoid syndrome	30.6	SST MEN1
2	neuroendocrine tumor	30.4	SST MEN1 CDKN1B
3	hereditary neuroendocrine tumor of small intestine	11.4
4	familial isolated pituitary adenoma	10.3	MEN1 CDKN1B
5	gastrointestinal neuroendocrine benign tumor	10.2	SST MEN1
6	non-functioning pancreatic endocrine tumor	10.2	SST MEN1
7	duodenal gastrinoma	10.2	SST MEN1
8	gastrinoma	10.2	SST MEN1
9	gastric neuroendocrine neoplasm	10.2	SST MEN1
10	multiple endocrine neoplasia, type iv	10.2	MEN1 CDKN1B
11	endocrine pancreas disease	10.2	SST MEN1
12	duodenal somatostatinoma	10.2	SST MEN1
13	somatostatinoma	10.2	SST MEN1
14	pancreatic gastrinoma	10.2	SST MEN1
15	pituitary infarct	10.2	SST MEN1
16	gastrointestinal neuroendocrine tumor	10.2	SST MEN1
17	carcinoid tumors, intestinal	10.2	SST MEN1
18	pancreatic cholera	10.2	SST MEN1
19	hormone producing pituitary cancer	10.2	SST MEN1
20	pulmonary neuroendocrine tumor	10.2	SST MEN1
21	pituitary apoplexy	10.2	SST MEN1
22	hyperpituitarism	10.1	SST MEN1
23	pituitary adenoma 1, multiple types	10.1	SST MEN1
24	serotonin syndrome	10.1	SST MEN1
25	pancreatic endocrine carcinoma	10.1	SST MEN1
26	duodenum cancer	10.1	SST MEN1
27	ewing sarcoma	10.1
28	neuroendocrine carcinoma	10.1
29	duodenum disease	10.1	SST MEN1
30	pituitary carcinoma	10.1	SST MEN1
31	pituitary tumors	10.1	SST MEN1
32	vipoma	10.1	SST MEN1
33	zollinger-ellison syndrome	10.1	SST MEN1
34	acth-secreting pituitary adenoma	10.1	SST MEN1 CDKN1B
35	pituitary adenoma	10.1	SST MEN1 CDKN1B
36	carney complex variant	10.1	SST MEN1 CDKN1B
37	thyroid gland medullary carcinoma	10.0	SST MEN1
38	multiple endocrine neoplasia	10.0	SST MEN1 CDKN1B
39	multiple endocrine neoplasia, type i	10.0	SST MEN1 CDKN1B
40	pancreatic cystadenoma	10.0	SST MEN1
41	functioning pituitary adenoma	10.0	SST MEN1
42	growth hormone secreting pituitary adenoma	9.9	SST MEN1
43	familial hypocalciuric hypercalcemia	9.9	MEN1 CDKN1B
44	small intestine benign neoplasm	9.0	SST PNMA2 NONO MLF1 MIR3137 MEN1

Graphical network of the top 20 diseases related to Small Intestine Neuroendocrine Neoplasm:

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Symptoms & Phenotypes for Small Intestine Neuroendocrine Neoplasm

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Drugs & Therapeutics for Small Intestine Neuroendocrine Neoplasm

Drugs for Small Intestine Neuroendocrine Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Liver Extracts

Interventional clinical trials:

#	Name	Status	NCT ID
1	Volumetric Imaging Follow up of Patients With Liver Metastases of Small Intestinal Neuroendocrine Tumors (NETs).	Unknown status	NCT03689231
2	Prophylactic Cholecystectomy is Not Mandatory in Patients Candidate to the Resection for Small Intestine Neuroendocrine Neoplasms: a Propensity Score-matched and Cost-minimization Analysis	Completed	NCT04780737
3	Diagnostic Performances of Urine and Plasma 5-hydroxyindolacetic Acid (5HIAA) Values in Patients With Small-intestine Neuroendocrine Tumors	Recruiting	NCT02826928
4	Resection of the Primary Tumor vs no Resection in Asymptomatic Patients With Unresectable Synchronous Liver Metastases From siNEN	Recruiting	NCT03442959

Search NIH Clinical Center for Small Intestine Neuroendocrine Neoplasm

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Genetic Tests for Small Intestine Neuroendocrine Neoplasm

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Anatomical Context for Small Intestine Neuroendocrine Neoplasm

MalaCards organs/tissues related to Small Intestine Neuroendocrine Neoplasm:

⁴⁰

Small Intestine, Liver

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Publications for Small Intestine Neuroendocrine Neoplasm

Articles related to Small Intestine Neuroendocrine Neoplasm:

(show all 15)

#	Title	Authors	PMID	Year
1	First Ex Vivo Results of Beta-Radioguided Surgery in Small Intestine Neuroendocrine Tumors with Y-90-DOTATOC. ⁶¹	Bertani E...Grana CM	33601932	2021
2	Current practice in approaching controversial diagnostic and therapeutic topics in gastroenteropancreatic neuroendocrine neoplasm management. Belgian multidisciplinary expert discussion based on a modified Delphi method. ⁶¹	Cuyle PJ...Verslype C	33321023	2020
3	Assessment of serotonin concentration in patients with a small-intestine neuroendocrine neoplasm and carcinoid syndrome treated with somatostatin analogues. ⁶¹	Gut P...Ruchala M	32643913	2020
4	Evaluation of 5-hydroxyindoloacetic acid excretion in urine in patients with small intestine neuroendocrine neoplasm and carcinoid syndrome treated with somatostatin analogues. ⁶¹	Gut P...Ruchala M	32304367	2019
5	ONCOGENE PANEL SEQUENCING ANALYSIS IDENTIFIES CANDIDATE ACTIONABLE GENES IN ADVANCED WELL-DIFFERENTIATED GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS. ⁶¹	Tirosh A...Kebebew E	30865533	2019
6	Transcriptional effects of 177Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice. ⁶¹	Spetz J...Forssell-Aronsson E	30895393	2019
7	Small Intestine Neuroendocrine Tumor in a Patient With MUTYH Adenomatous Polyposis-Case Report and SEER Analysis. ⁶¹	Weidner TK...Mishra N	29843990	2018
8	Prognostic Utility of 24-Hour Urinary 5-HIAA Doubling Time in Patients With Neuroendocrine Tumors. ⁶¹	Tirosh A...Kebebew E	30084688	2018
9	Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu[Lu]-octreotate therapy. ⁶¹	Spetz J...Forssell-Aronsson E	29502008	2018
10	Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to 177Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine Tumor. ⁶¹	Montelius M...Forssell-Aronsson E	29331677	2018
11	Functional Defects From Endocrine Disease-Associated Mutations in HLXB9 and Its Interacting Partner, NONO. ⁶¹	Kharade SS...Agarwal SK	29309627	2018
12	Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1. ⁶¹	Dalmo J...Forssell-Aronsson E	28097640	2017
13	Genetic associations with neuroendocrine tumor risk: results from a genome-wide association study. ⁶¹	Du Y...Kulke MH	27492634	2016
14	Feasibility of Radio-Guided Surgery with ⁶⁸Gallium-DOTATATE in Patients with Gastro-Entero-Pancreatic Neuroendocrine Tumors. ⁶¹	Sadowski SM...Kebebew E	26350374	2015
15	Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines. ⁶¹	Drozdov I...Modlin IM	19634160	2009

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Genes for Small Intestine Neuroendocrine Neoplasm

Genes related to Small Intestine Neuroendocrine Neoplasm (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HOOK3	Hook Microtubule Tethering Protein 3	Protein Coding	7.19	DISEASES inferred ¹⁵
2	MIR3137	MicroRNA 3137	RNA Gene	6.53	DISEASES inferred ¹⁵
3	MLF1	Myeloid Leukemia Factor 1	Protein Coding	6.4	DISEASES inferred ¹⁵
4	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	6.21	DISEASES inferred ¹⁵
5	NONO	Non-POU Domain Containing Octamer Binding	Protein Coding	6.12	DISEASES inferred ¹⁵
6	MEN1	Menin 1	Protein Coding	5.92	DISEASES inferred ¹⁵
7	IPMK	Inositol Polyphosphate Multikinase	Protein Coding	5.84	DISEASES inferred ¹⁵
8	SST	Somatostatin	Protein Coding	5.72	DISEASES inferred ¹⁵
9	KIF16B	Kinesin Family Member 16B	Protein Coding	5.61	DISEASES inferred ¹⁵
10	CARD11	Caspase Recruitment Domain Family Member 11	Protein Coding	5.55	DISEASES inferred ¹⁵
11	PNMA2	PNMA Family Member 2	Protein Coding	5.54	DISEASES inferred ¹⁵
12	FEV	FEV Transcription Factor, ETS Family Member	Protein Coding	5.52	DISEASES inferred ¹⁵
13	HAL	Histidine Ammonia-Lyase	Protein Coding	5.42	DISEASES inferred ¹⁵
14	CCDC89	Coiled-Coil Domain Containing 89	Protein Coding	5.3	DISEASES inferred ¹⁵

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Variations for Small Intestine Neuroendocrine Neoplasm

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Expression for Small Intestine Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Small Intestine Neuroendocrine Neoplasm.

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Pathways for Small Intestine Neuroendocrine Neoplasm

Pathways related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Transcriptional misregulation in cancer ³⁶	11.21	MLF1 MEN1 FEV CDKN1B

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GO Terms for Small Intestine Neuroendocrine Neoplasm

Biological processes related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to amino acid	GO:0043200	9.16	SST CDKN1B
2	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO:0045736	8.96	MEN1 CDKN1B
3	early endosome to late endosome transport	GO:0045022	8.62	KIF16B HOOK3

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Sources for Small Intestine Neuroendocrine Neoplasm

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