Small Intestine Neuroendocrine Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Small Intestine Neuroendocrine Neoplasm

MalaCards integrated aliases for Small Intestine Neuroendocrine Neoplasm:

Name: Small Intestine Neuroendocrine Neoplasm ¹² ¹⁵

Small Intestine Neuroendocrine Tumor ¹² ¹⁷

Neuroendocrine Neoplasm of the Small Intestine ⁵⁸

Neuroendocrine Tumor of the Small Intestine ⁵⁸

Small Intestinal Neuroendocrine Neoplasm ⁷¹

Neuroendocrine Tumor of Small Bowel ⁵⁸

Net of the Small Intestine ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Gastrointestinal diseases Endocrine diseases Neuronal diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare gastroenterological diseases

Rare endocrine diseases

External Ids:

Disease Ontology ¹² DOID:4434

NCIt ⁴⁹ C5803

Orphanet ⁵⁸ ORPHA423975

EFO ¹⁷ EFO_1001928

UMLS ⁷¹ C1336005

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Summaries for Small Intestine Neuroendocrine Neoplasm

MalaCards based summary : Small Intestine Neuroendocrine Neoplasm, also known as small intestine neuroendocrine tumor, is related to gastrointestinal neuroendocrine tumor and thyroid gland medullary carcinoma. An important gene associated with Small Intestine Neuroendocrine Neoplasm is HOOK3 (Hook Microtubule Tethering Protein 3), and among its related pathways/superpathways is Transcriptional misregulation in cancer. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and thyroid.

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Related Diseases for Small Intestine Neuroendocrine Neoplasm

Diseases related to Small Intestine Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)

#	Related Disease	Score	Top Affiliating Genes
1	gastrointestinal neuroendocrine tumor	30.2	SPINK5 MEN1
2	thyroid gland medullary carcinoma	30.0	SPINK5 MEN1
3	hereditary neuroendocrine tumor of small intestine	11.6
4	neuroendocrine tumor	10.2
5	gastrointestinal neuroendocrine benign tumor	10.2	SPINK5 MEN1
6	gastric gastrinoma	10.2	SPINK5 MEN1
7	gastric neuroendocrine neoplasm	10.2	SPINK5 MEN1
8	duodenal gastrinoma	10.2	SPINK5 MEN1
9	duodenal somatostatinoma	10.2	SPINK5 MEN1
10	somatostatinoma	10.2	SPINK5 MEN1
11	esophageal neuroendocrine tumor	10.2	SPINK5 MEN1
12	familial isolated pituitary adenoma	10.2	MEN1 CDKN1B
13	pancreatic gastrinoma	10.2	SPINK5 MEN1
14	pulmonary neuroendocrine tumor	10.1	SPINK5 MEN1
15	pancreatic endocrine carcinoma	10.1	SPINK5 MEN1
16	carcinoid syndrome	10.1
17	multiple endocrine neoplasia	10.1	MEN1 CDKN1B
18	duodenum disease	10.1	SPINK5 MEN1
19	multiple endocrine neoplasia, type iv	10.1	MEN1 CDKN1B
20	duodenum cancer	10.1	SPINK5 MEN1
21	adenocarcinoma	10.1
22	vipoma	10.1	SPINK5 MEN1
23	pancreatic cystadenoma	10.0	SPINK5 MEN1
24	appendicitis	10.0
25	lung benign neoplasm	10.0
26	lymphoma, hodgkin, classic	10.0
27	lymphoma, non-hodgkin, familial	10.0
28	ewing sarcoma	10.0
29	gastrointestinal carcinoma	10.0
30	short bowel syndrome	10.0
31	neuroendocrine carcinoma	10.0
32	gastrointestinal system cancer	10.0
33	multiple endocrine neoplasia, type iia	10.0	MEN1 CDKN1B
34	breast cancer	9.9
35	leukemia, chronic lymphocytic	9.9
36	thyroid carcinoma, familial medullary	9.9
37	celiac disease 1	9.9
38	lymphocytic leukemia	9.9
39	gestational diabetes	9.9
40	kidney cancer	9.9
41	myoma	9.9
42	severe combined immunodeficiency	9.9
43	intestinal obstruction	9.9
44	ileus	9.9
45	lymph node disease	9.9
46	mutyh polyposis	9.9
47	thyroid carcinoma	9.9
48	multiple endocrine neoplasia, type i	9.9	SPINK5 MEN1 CDKN1B
49	carney complex variant	9.9	MEN1 CDKN1B
50	islet cell tumor	9.9	SPINK5 MEN1

Graphical network of the top 20 diseases related to Small Intestine Neuroendocrine Neoplasm:

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Symptoms & Phenotypes for Small Intestine Neuroendocrine Neoplasm

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Drugs & Therapeutics for Small Intestine Neuroendocrine Neoplasm

Drugs for Small Intestine Neuroendocrine Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Liver Extracts

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Resection of the Primary Tumor vs no Resection in Asymptomatic Patients With Unresectable Synchronous Liver Metastases From siNEN	Recruiting	NCT03442959

Search NIH Clinical Center for Small Intestine Neuroendocrine Neoplasm

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Genetic Tests for Small Intestine Neuroendocrine Neoplasm

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Anatomical Context for Small Intestine Neuroendocrine Neoplasm

MalaCards organs/tissues related to Small Intestine Neuroendocrine Neoplasm:

⁴⁰

Small Intestine, Liver, Thyroid, Lung, Lymph Node, Kidney, Breast

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Publications for Small Intestine Neuroendocrine Neoplasm

Articles related to Small Intestine Neuroendocrine Neoplasm:

(show all 11)

#	Title	Authors	PMID	Year
1	ONCOGENE PANEL SEQUENCING ANALYSIS IDENTIFIES CANDIDATE ACTIONABLE GENES IN ADVANCED WELL-DIFFERENTIATED GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS. ⁶¹	Tirosh A...Kebebew E	30865533	2019
2	Transcriptional effects of 177Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice. ⁶¹	Spetz J...Forssell-Aronsson E	30895393	2019
3	Small Intestine Neuroendocrine Tumor in a Patient With MUTYH Adenomatous Polyposis-Case Report and SEER Analysis. ⁶¹	Weidner TK...Mishra N	29843990	2018
4	Prognostic Utility of 24-Hour Urinary 5-HIAA Doubling Time in Patients With Neuroendocrine Tumors. ⁶¹	Tirosh A...Kebebew E	30084688	2018
5	Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu[Lu]-octreotate therapy. ⁶¹	Spetz J...Forssell-Aronsson E	29502008	2018
6	Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to 177Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine Tumor. ⁶¹	Montelius M...Forssell-Aronsson E	29331677	2018
7	Functional Defects From Endocrine Disease-Associated Mutations in HLXB9 and Its Interacting Partner, NONO. ⁶¹	Kharade SS...Agarwal SK	29309627	2018
8	Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1. ⁶¹	Dalmo J...Forssell-Aronsson E	28097640	2017
9	Genetic associations with neuroendocrine tumor risk: results from a genome-wide association study. ⁶¹	Du Y...Kulke MH	27492634	2016
10	Feasibility of Radio-Guided Surgery with ⁶⁸Gallium-DOTATATE in Patients with Gastro-Entero-Pancreatic Neuroendocrine Tumors. ⁶¹	Sadowski SM...Kebebew E	26350374	2015
11	Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines. ⁶¹	Drozdov I...Modlin IM	19634160	2009

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Genes for Small Intestine Neuroendocrine Neoplasm

Genes related to Small Intestine Neuroendocrine Neoplasm (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HOOK3	Hook Microtubule Tethering Protein 3	Protein Coding	7.26	DISEASES inferred ¹⁵
2	SPINK5	Serine Peptidase Inhibitor Kazal Type 5	Protein Coding	7.11	DISEASES inferred ¹⁵
3	MIR3137	MicroRNA 3137	RNA Gene	6.94	DISEASES inferred ¹⁵
4	MLF1	Myeloid Leukemia Factor 1	Protein Coding	6.48	DISEASES inferred ¹⁵
5	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	6	DISEASES inferred ¹⁵
6	NONO	Non-POU Domain Containing Octamer Binding	Protein Coding	5.83	DISEASES inferred ¹⁵
7	PCNX1	Pecanex 1	Protein Coding	5.82	DISEASES inferred ¹⁵
8	CDR2L	Cerebellar Degeneration Related Protein 2 Like	Protein Coding	5.8	DISEASES inferred ¹⁵
9	MEN1	Menin 1	Protein Coding	5.73	DISEASES inferred ¹⁵
10	IPMK	Inositol Polyphosphate Multikinase	Protein Coding	5.72	DISEASES inferred ¹⁵
11	CARD11	Caspase Recruitment Domain Family Member 11	Protein Coding	5.62	DISEASES inferred ¹⁵
12	KIF16B	Kinesin Family Member 16B	Protein Coding	5.61	DISEASES inferred ¹⁵
13	FEV	FEV Transcription Factor, ETS Family Member	Protein Coding	5.46	DISEASES inferred ¹⁵

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Variations for Small Intestine Neuroendocrine Neoplasm

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Expression for Small Intestine Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Small Intestine Neuroendocrine Neoplasm.

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Pathways for Small Intestine Neuroendocrine Neoplasm

Pathways related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Transcriptional misregulation in cancer ³⁶	11.19	MLF1 MEN1 FEV CDKN1B

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GO Terms for Small Intestine Neuroendocrine Neoplasm

Biological processes related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell cycle	GO:0045786	9.26	MEN1 CDKN1B
2	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO:0045736	9.16	MEN1 CDKN1B
3	early endosome to late endosome transport	GO:0045022	8.96	KIF16B HOOK3
4	regulation of T cell differentiation	GO:0045580	8.62	SPINK5 CARD11

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Sources for Small Intestine Neuroendocrine Neoplasm

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