Small Intestine Neuroendocrine Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Small Intestine Neuroendocrine Neoplasm

MalaCards integrated aliases for Small Intestine Neuroendocrine Neoplasm:

Name: Small Intestine Neuroendocrine Neoplasm ¹² ¹⁵

Small Intestinal Neuroendocrine Neoplasm ⁷³

Small Intestine Neuroendocrine Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Endocrine diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4434

NCIt ⁵⁰ C5803

UMLS ⁷³ C1336005

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Summaries for Small Intestine Neuroendocrine Neoplasm

MalaCards based summary : Small Intestine Neuroendocrine Neoplasm, also known as small intestinal neuroendocrine neoplasm, is related to neuroendocrine tumor and gastrinoma. An important gene associated with Small Intestine Neuroendocrine Neoplasm is MEN1 (Menin 1). Affiliated tissues include small intestine, liver and pituitary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Small Intestine Neuroendocrine Neoplasm

Diseases related to Small Intestine Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)

#	Related Disease	Score	Top Affiliating Genes
1	neuroendocrine tumor	10.1
2	gastrinoma	10.1	MEN1 SCT
3	pancreatic gastrinoma	10.1	MEN1 SCT
4	pancreatic cholera	10.1	MEN1 SCT
5	duodenal disease	10.1	MEN1 SCT
6	zollinger-ellison syndrome	10.1	MEN1 SCT
7	pediatric ependymoma	10.1	BCAT1 MEN1
8	small intestine cancer	10.0	MEN1 SCT
9	peptic ulcer disease	10.0	MEN1 SCT
10	maturity-onset diabetes of the young, type 7	10.0	HMX1 SCT
11	lipomatosis, multiple	10.0	MEN1 MNX1
12	multiple endocrine neoplasia, type i	10.0	MEN1 SCT
13	insulinoma	9.9	MEN1 SCT
14	ectopic cushing syndrome	9.9	MEN1 SSTR1
15	serotonin syndrome	9.9	MEN1 SSTR1
16	duodenal gastrinoma	9.9	HMX1 MEN1 SCT
17	pituitary adenoma, prolactin-secreting	9.9	MEN1 SSTR1
18	acromegaly	9.9	MEN1 SSTR1
19	thyroid carcinoma, familial medullary	9.7	MEN1 SSTR1
20	intestinal neuroendocrine benign tumor	9.2	BCAT1 HMX1 MEN1 MNX1 SCT SSTR1

Graphical network of the top 20 diseases related to Small Intestine Neuroendocrine Neoplasm:

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Symptoms & Phenotypes for Small Intestine Neuroendocrine Neoplasm

GenomeRNAi Phenotypes related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

²⁶ (show all 20)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.66	MNX1
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.66	MEN1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	9.66	MEN1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-128	9.66	MEN1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-135	9.66	SSTR1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	9.66	SSTR1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	9.66	SSTR1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	9.66	SSTR1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.66	MEN1 MNX1 SSTR1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	9.66	MNX1
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	9.66	MNX1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.66	MNX1
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.66	MEN1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	9.66	MNX1
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	9.66	MEN1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	9.66	MEN1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	9.66	MNX1
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.66	SSTR1
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	9.66	SSTR1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	9.66	MEN1

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Drugs & Therapeutics for Small Intestine Neuroendocrine Neoplasm

Search Clinical Trials , NIH Clinical Center for Small Intestine Neuroendocrine Neoplasm

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Genetic Tests for Small Intestine Neuroendocrine Neoplasm

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Anatomical Context for Small Intestine Neuroendocrine Neoplasm

MalaCards organs/tissues related to Small Intestine Neuroendocrine Neoplasm:

⁴¹

Small Intestine, Liver, Pituitary, Thyroid

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Publications for Small Intestine Neuroendocrine Neoplasm

Articles related to Small Intestine Neuroendocrine Neoplasm:

#	Title	Authors	Year
1	Chromogranin A and its fragments as regulators of small intestinal neuroendocrine neoplasm proliferation. ( 24260544 )	Giovinazzo F....Kidd M.	2013
2	Microencapsulation of small intestinal neuroendocrine neoplasm cells for tumor model studies. ( 22435758 )	Rokstad AM...Kidd M	2012

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Genes for Small Intestine Neuroendocrine Neoplasm

Genes related to Small Intestine Neuroendocrine Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MEN1	Menin 1	Protein Coding	16.94	DISEASES inferred ¹⁵
2	SCT	Secretin	Protein Coding	15.86	DISEASES inferred ¹⁵
3	BCAT1	Branched Chain Amino Acid Transaminase 1	Protein Coding	14.87	DISEASES inferred ¹⁵
4	MNX1	Motor Neuron And Pancreas Homeobox 1	Protein Coding	14.6	DISEASES inferred ¹⁵
5	SSTR1	Somatostatin Receptor 1	Protein Coding	14.35	DISEASES inferred ¹⁵
6	HMX1	H6 Family Homeobox 1	Protein Coding	14.33	DISEASES inferred ¹⁵

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Variations for Small Intestine Neuroendocrine Neoplasm

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Expression for Small Intestine Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Small Intestine Neuroendocrine Neoplasm.

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Pathways for Small Intestine Neuroendocrine Neoplasm

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GO Terms for Small Intestine Neuroendocrine Neoplasm

Molecular functions related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein N-terminus binding	GO:0047485	8.62	MEN1 SCT

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