MCID: SML004
MIFTS: 27

Small Intestine Neuroendocrine Neoplasm

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Small Intestine Neuroendocrine Neoplasm

MalaCards integrated aliases for Small Intestine Neuroendocrine Neoplasm:

Name: Small Intestine Neuroendocrine Neoplasm 12 15
Small Intestine Neuroendocrine Tumor 12 17
Neuroendocrine Neoplasm of the Small Intestine 58
Neuroendocrine Tumor of the Small Intestine 58
Small Intestinal Neuroendocrine Neoplasm 71
Neuroendocrine Tumor of Small Bowel 58
Net of the Small Intestine 58

Classifications:

Orphanet: 58  
Rare gastroenterological diseases
Rare endocrine diseases


External Ids:

Disease Ontology 12 DOID:4434
NCIt 49 C5803
Orphanet 58 ORPHA423975
UMLS 71 C1336005

Summaries for Small Intestine Neuroendocrine Neoplasm

MalaCards based summary : Small Intestine Neuroendocrine Neoplasm, also known as small intestine neuroendocrine tumor, is related to carcinoid syndrome and thyroid carcinoma, familial medullary. An important gene associated with Small Intestine Neuroendocrine Neoplasm is HOOK3 (Hook Microtubule Tethering Protein 3), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Transcriptional misregulation in cancer. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Small Intestine Neuroendocrine Neoplasm

Diseases related to Small Intestine Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 carcinoid syndrome 30.0 SST MEN1
2 thyroid carcinoma, familial medullary 29.5 SSTR1 SST MEN1
3 gastrointestinal neuroendocrine tumor 29.3 SSTR1 SST SPINK5 MEN1
4 thyroid gland medullary carcinoma 29.3 SSTR1 SST SPINK5 MEN1
5 hereditary neuroendocrine tumor of small intestine 11.6
6 multiple endocrine neoplasia 10.3 MEN1 CDKN1B
7 gastric gastrinoma 10.3 SPINK5 MEN1
8 neuroendocrine tumor 10.3
9 familial isolated pituitary adenoma 10.3 MEN1 CDKN1B
10 anal neuroendocrine tumor 10.2 SST SPINK5
11 multiple endocrine neoplasia, type iv 10.1 MEN1 CDKN1B
12 carotid body cancer 10.1 SST SPINK5
13 tricuspid valve stenosis 10.1 SST SPINK5
14 non-functioning pancreatic endocrine tumor 10.1 SST MEN1
15 adenocarcinoma 10.1
16 pituitary infarct 10.1 SST MEN1
17 meckel diverticulum 10.1 SST SPINK5
18 carcinoid tumors, intestinal 10.0 SST MEN1
19 appendicitis 10.0
20 pituitary apoplexy 10.0 SST MEN1
21 gastrointestinal neuroendocrine benign tumor 10.0 SST SPINK5 MEN1
22 gastric neuroendocrine neoplasm 10.0 SST SPINK5 MEN1
23 duodenal gastrinoma 10.0 SST SPINK5 MEN1
24 lung benign neoplasm 10.0
25 pancreatic cholera 10.0 SST SPINK5 MEN1
26 pancreatic gastrinoma 10.0 SST SPINK5 MEN1
27 endocrine pancreas disease 10.0 SST SPINK5 MEN1
28 duodenal somatostatinoma 10.0 SST SPINK5 MEN1
29 somatostatinoma 10.0 SST SPINK5 MEN1
30 pulmonary neuroendocrine tumor 10.0 SST SPINK5 MEN1
31 pancreatic endocrine carcinoma 10.0 SST SPINK5 MEN1
32 lymphoma, hodgkin, classic 10.0
33 lymphoma, non-hodgkin, familial 10.0
34 ewing sarcoma 10.0
35 gastrointestinal carcinoma 10.0
36 short bowel syndrome 10.0
37 neuroendocrine carcinoma 10.0
38 gastrointestinal system cancer 10.0
39 duodenum cancer 10.0 SST SPINK5 MEN1
40 pituitary carcinoma 10.0 SST MEN1
41 duodenum disease 10.0 SST SPINK5 MEN1
42 vipoma 9.9 SST SPINK5 MEN1
43 breast cancer 9.9
44 leukemia, chronic lymphocytic 9.9
45 celiac disease 1 9.9
46 gestational diabetes 9.9
47 kidney cancer 9.9
48 myoma 9.9
49 severe combined immunodeficiency 9.9
50 intestinal obstruction 9.9

Graphical network of the top 20 diseases related to Small Intestine Neuroendocrine Neoplasm:



Diseases related to Small Intestine Neuroendocrine Neoplasm

Symptoms & Phenotypes for Small Intestine Neuroendocrine Neoplasm

GenomeRNAi Phenotypes related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 CARD11 CDR2L
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 CARD11 CDR2L IPMK SST
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.17 CDR2L

Drugs & Therapeutics for Small Intestine Neuroendocrine Neoplasm

Drugs for Small Intestine Neuroendocrine Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Resection of the Primary Tumor vs no Resection in Asymptomatic Patients With Unresectable Synchronous Liver Metastases From siNEN Recruiting NCT03442959

Search NIH Clinical Center for Small Intestine Neuroendocrine Neoplasm

Genetic Tests for Small Intestine Neuroendocrine Neoplasm

Anatomical Context for Small Intestine Neuroendocrine Neoplasm

MalaCards organs/tissues related to Small Intestine Neuroendocrine Neoplasm:

40
Small Intestine, Liver, Lung

Publications for Small Intestine Neuroendocrine Neoplasm

Articles related to Small Intestine Neuroendocrine Neoplasm:

(show all 12)
# Title Authors PMID Year
1
Evaluation of 5-hydroxyindoloacetic acid excretion in urine in patients with small intestine neuroendocrine neoplasm and carcinoid syndrome treated with somatostatin analogues. 61
32304367 2019
2
ONCOGENE PANEL SEQUENCING ANALYSIS IDENTIFIES CANDIDATE ACTIONABLE GENES IN ADVANCED WELL-DIFFERENTIATED GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS. 61
30865533 2019
3
Transcriptional effects of 177Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice. 61
30895393 2019
4
Small Intestine Neuroendocrine Tumor in a Patient With MUTYH Adenomatous Polyposis-Case Report and SEER Analysis. 61
29843990 2018
5
Prognostic Utility of 24-Hour Urinary 5-HIAA Doubling Time in Patients With Neuroendocrine Tumors. 61
30084688 2018
6
Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu[Lu]-octreotate therapy. 61
29502008 2018
7
Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to 177Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine Tumor. 61
29331677 2018
8
Functional Defects From Endocrine Disease-Associated Mutations in HLXB9 and Its Interacting Partner, NONO. 61
29309627 2018
9
Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1. 61
28097640 2017
10
Genetic associations with neuroendocrine tumor risk: results from a genome-wide association study. 61
27492634 2016
11
Feasibility of Radio-Guided Surgery with ⁶⁸Gallium-DOTATATE in Patients with Gastro-Entero-Pancreatic Neuroendocrine Tumors. 61
26350374 2015
12
Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines. 61
19634160 2009

Variations for Small Intestine Neuroendocrine Neoplasm

Expression for Small Intestine Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Small Intestine Neuroendocrine Neoplasm.

Pathways for Small Intestine Neuroendocrine Neoplasm

Pathways related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.34 SSTR1 SST FEV
2 11.21 MLF1 MEN1 FEV CDKN1B

GO Terms for Small Intestine Neuroendocrine Neoplasm

Biological processes related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.46 SSTR1 SST MEN1 CDKN1B
2 response to amino acid GO:0043200 9.32 SST CDKN1B
3 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.26 MEN1 CDKN1B
4 early endosome to late endosome transport GO:0045022 8.96 KIF16B HOOK3
5 regulation of T cell differentiation GO:0045580 8.62 SPINK5 CARD11

Sources for Small Intestine Neuroendocrine Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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