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MCID: SML019
MIFTS: 57

Smallpox

Categories: Rare diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Smallpox

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MalaCards integrated aliases for Smallpox:

Name: Smallpox 12 76 53 55 43 3 44 15 73
Ordinary Smallpox 12
Variola 53

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:8736
ICD10 33 B03
ICD9CM 35 050 050.9
MeSH 44 D012899
NCIt 50 C35027
UMLS 73 C0037354
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Summaries for Smallpox

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MedlinePlus : 43 Smallpox is a disease caused by the Variola major virus. Some experts say that over the centuries it has killed more people than all other infectious diseases combined. Worldwide immunization stopped the spread of smallpox three decades ago. The last case was reported in 1977. Two research labs still keep small amounts of the virus. Experts fear bioterrorists could use the virus to spread disease. Smallpox spreads very easily from person to person. Symptoms are flu-like. They include High fever Fatigue Headache Backache A rash with flat red sores There is no treatment. Fluids and medicines for pain or fever can help control symptoms. Most people recover, but some can die. Those who do recover may have severe scars. The U.S. stopped routine smallpox vaccinations in 1972. Military and other high-risk groups continue to get the vaccine. The U.S. has increased its supply of the vaccine in recent years. The vaccine makes some people sick, so doctors save it for those at highest risk of disease. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Smallpox, also known as ordinary smallpox, is related to variola major and viral infectious disease, and has symptoms including exanthema, fever and pruritus. An important gene associated with Smallpox is IL18R1 (Interleukin 18 Receptor 1), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Vaccines and Rho(D) Immune Globulin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in Variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. The infection results in_formation_of lesions, first on the face, hands and forearms and later on the trunk.

CDC : 3 Thousands of years ago, variola virus (smallpox virus) emerged and began causing illness and deaths in human populations, with smallpox outbreaks occurring from time to time. Thanks to the success of vaccination, the last natural outbreak of smallpox in the United States occurred in 1949. In 1980, the World Health Assembly declared smallpox eradicated (eliminated), and no cases of naturally occurring smallpox have happened since. 

Wikipedia : 76 Smallpox was an infectious disease caused by one of two virus variants, Variola major and Variola minor.... more...

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Related Diseases for Smallpox

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Diseases related to Smallpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 variola major 33.6 IFNG IL2
2 viral infectious disease 31.4 IFNG IL2 TNF
3 erythema multiforme 30.0 IFNG IL2 TNF
4 schistosomiasis 29.9 IFNG IL2 TNF
5 acquired immunodeficiency syndrome 29.3 CSF2 IFNG IL2 TNF
6 arthritis 29.2 CSF2 IFNG IL18 TNF
7 dermatitis, atopic 29.1 CSF2 IFNG IL18 IL2 TNF
8 inflammatory bowel disease 28.6 IFNG IL12RB2 IL18 IL18R1 IL2 TNF
9 cowpox 11.5
10 variola minor 11.4
11 vaccinia 11.4
12 monkeypox 11.3
13 systemic onset juvenile idiopathic arthritis 10.7 IL18 TNF
14 staphylococcal toxic shock syndrome 10.7 IFNG TNF
15 chronic beryllium disease 10.6 IFNG TNF
16 anthracosis 10.6 IL18R1 TNF
17 oral tuberculosis 10.6 IL2 TNF
18 pleural tuberculosis 10.6 IFNG IL18 TNF
19 fixed drug eruption 10.6 IFNG IL2
20 rasmussen encephalitis 10.6 IFNG IL18 TNF
21 melioidosis 10.6 IFNG IL18 TNF
22 berylliosis 10.6 IFNG IL2
23 lymphadenitis 10.6 IFNG IL18 TNF
24 autoinflammation, lipodystrophy, and dermatosis syndrome 10.6 IFNG IL18 TNF
25 gillessen-kaesbach-nishimura syndrome 10.5 IL18 IL18BP
26 plasmodium falciparum malaria 10.5 IFNG IL18 TNF
27 relapsing-remitting multiple sclerosis 10.5 IFNG IL18 TNF
28 streptococcal toxic-shock syndrome 10.4 IL2 TNF
29 autoimmune myocarditis 10.4 IFNG IL2 TNF
30 mycobacterium tuberculosis 1 10.4 IFNG IL18 TNF
31 clonorchiasis 10.4 IFNG IL2 TNF
32 crohn's colitis 10.4 IFNG IL2 TNF
33 microscopic colitis 10.4 IFNG IL2 TNF
34 posterior uveitis 10.4 IFNG IL2 TNF
35 intermediate uveitis 10.4 IFNG IL2 TNF
36 coccidiosis 10.4 IFNG IL2 TNF
37 hematopoietic stem cell transplantation 10.4 IFNG IL2 TNF
38 hemophagocytic lymphohistiocytosis 10.4 IFNG IL18 TNF
39 hypersensitivity reaction type iv disease 10.4 IFNG IL2 TNF
40 pleurisy 10.4 IFNG IL2 TNF
41 farmer's lung 10.4 IL2 TNF
42 brucellosis 10.4 IFNG IL2 TNF
43 tonsillitis 10.3 IFNG IL2 TNF
44 human immunodeficiency virus infectious disease 10.3 IFNG IL2 TNF
45 spondyloarthropathy 10.3 IFNG IL2 TNF
46 filariasis 10.3 IFNG IL2 TNF
47 uremic pruritus 10.3 IL18 IL2
48 parasitic protozoa infectious disease 10.3 IFNG IL2 TNF
49 keratoconjunctivitis 10.3 IFNG IL2 TNF
50 primary bacterial infectious disease 10.3 IFNG IL2 TNF

Graphical network of the top 20 diseases related to Smallpox:



Diseases related to Smallpox
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Symptoms & Phenotypes for Smallpox

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UMLS symptoms related to Smallpox:


exanthema, fever, pruritus

MGI Mouse Phenotypes related to Smallpox:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.06 IL18R1 IL2 GOLGA3 GZMA PRKCQ IFNG
2 homeostasis/metabolism MP:0005376 10 IL18BP CSF2 CSMD1 GOLGA3 IL2 PRKCQ
3 endocrine/exocrine gland MP:0005379 9.97 IL18BP CSF2 GOLGA3 IL2 PRKCQ IFNG
4 immune system MP:0005387 9.85 CSF2 IL18R1 IL2 GZMA PRKCQ IFNG
5 neoplasm MP:0002006 9.5 CSF2 IL2 GZMA PRKCQ IFNG TNF
6 reproductive system MP:0005389 9.23 IL18BP CSF2 GOLGA3 IL2 PRKCQ IFNG
Sources

Drugs & Therapeutics for Smallpox

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Drugs for Smallpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
2 Rho(D) Immune Globulin Phase 4,Phase 2,Phase 1
3 gamma-Globulins Phase 4,Phase 2,Phase 1
4 Antibodies Phase 4,Phase 2,Phase 1
5 Immunoglobulins Phase 4,Phase 2,Phase 1
6 Immunoglobulins, Intravenous Phase 4,Phase 2,Phase 1
7
Phenol Approved, Experimental Phase 2 108-95-2 996
8
Benzocaine Approved, Investigational Phase 1, Phase 2 1994-09-7, 94-09-7 2337
9 tannic acid Approved, Nutraceutical Phase 1, Phase 2
10
Mannitol Approved, Investigational Phase 1 69-65-8 453 6251
11 interferons Phase 1
12 diuretics Phase 1
13 Cathartics Phase 1
14 Adjuvants, Immunologic Phase 1
15 Gastrointestinal Agents Phase 1
16 Natriuretic Agents Phase 1
17 Anti-Bacterial Agents Phase 1
18 Antibiotics, Antitubercular Phase 1
19 Pharmaceutical Solutions Phase 1
20 Poly I-C Phase 1
21 Poly ICLC Phase 1
22 Anti-Infective Agents Phase 1
23 Interferon Inducers Phase 1
24 Keyhole-limpet hemocyanin Phase 1
25 Krestin Phase 1
26 Laxatives Phase 1
27 Protective Agents Phase 1
28 Liver Extracts Phase 1
29 Radiation-Protective Agents Phase 1
30 Antiviral Agents Phase 1
31 Carboxymethylcellulose Sodium Phase 1
32 Interferon-gamma

Interventional clinical trials:

(show top 50) (show all 83)
# Name Status NCT ID Phase Drugs
1 Vaccinia Vaccine (ACAM2000) for the Production of Vaccinia Immune Globulin Intravenous(VIGIV) Completed NCT01158157 Phase 4
2 Special Access Program IMVAMUNE® Completed NCT03472014 Phase 4
3 VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIV Recruiting NCT02443623 Phase 4
4 Safety and Efficacy of CJ Smallpox Vaccine in Previously Vaccinated Healthy Volunteers Completed NCT01317238 Phase 3 smallpox vaccine CJ-50300
5 Safety and Efficacy of CJ Smallpox Vaccine in Healthy Volunteers Completed NCT01056770 Phase 3 smallpox vaccine CJ-50300
6 A Trial to Evaluate Immunogenicity and Safety of Three Consecutive Production Lots of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in Healthy, Vaccinia-naïve Subjects Completed NCT01144637 Phase 3
7 Safety and Efficacy of CJ-50300 in Healthy Volunteers Completed NCT00607243 Phase 2, Phase 3
8 A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound Tecovirimat Completed NCT02474589 Phase 3 tecovirimat
9 IMVAMUNE® Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the Congo Recruiting NCT02977715 Phase 3
10 A Non-inferiority Trial to Compare MVA-BN® Smallpox Vaccine to ACAM2000® Active, not recruiting NCT01913353 Phase 3
11 Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated Volunteers Unknown status NCT00103584 Phase 1, Phase 2
12 Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection Completed NCT02038881 Phase 2
13 Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination Completed NCT00053495 Phase 2
14 Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated Adults Completed NCT00053482 Phase 2
15 Phase 2 Study of Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Smallpox Vaccine Completed NCT00466245 Phase 2 MVA Smallpox vaccine;Placebo
16 Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young Adults Completed NCT00258947 Phase 2
17 Dressing Preparations for Smallpox Completed NCT00063856 Phase 1, Phase 2
18 A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy Subjects Completed NCT01668537 Phase 2
19 APSV in Vaccinia Naive Adults Completed NCT00050518 Phase 2
20 Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE® Completed NCT01827371 Phase 2
21 A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced Subjects Completed NCT00857493 Phase 2
22 Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine. Completed NCT00189956 Phase 2
23 A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults Completed NCT00026611 Phase 2
24 A Randomized, Double-blind, Placebo-controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE™) Smallpox Vaccine in Healthy Subjects Completed NCT00316524 Phase 2
25 MVA Post-Event: Administration Timing and Boost Study Completed NCT00437021 Phase 1, Phase 2 Placebo (subcutaneous);Placebo (scarification)
26 Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered Intradermally Completed NCT00914732 Phase 2
27 Expanded Dryvax Dilution Study in Previously Vaccinated Adults Completed NCT00050505 Phase 2
28 ACAM 3000 MVA at Harvard Medical School Completed NCT00133575 Phase 1, Phase 2
29 Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected Patients Completed NCT00316589 Phase 2
30 A Phase II Study on Immunogenicity and Safety of MVA-BN® (IMVAMUNE™) Smallpox Vaccine in Subjects With Atopic Dermatitis Completed NCT00316602 Phase 2
31 Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in HIV Infected Patients Completed NCT00189904 Phase 1, Phase 2
32 Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOT Completed NCT00038987 Phase 1, Phase 2
33 High Dose IMVAMUNE® in Vaccinia-Naive Individuals Completed NCT00879762 Phase 2 Placebo
34 Dryvax Dilution-Prev Vacc Adults Completed NCT00032708 Phase 2
35 An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 Vaccinees Completed NCT00686582 Phase 2
36 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2 NP-016 Vaccine Immune Globulin (IV-VIG)
37 Immune Response to Yellow Fever Vaccination in Adults With Atopic Dermatitis Completed NCT00723489 Phase 1, Phase 2 YFV-17D Placebo
38 A Study to Assess the Effectiveness of a New Malaria Vaccine Candidate by Infecting Vaccinated Volunteers With Malaria Parasites Completed NCT00890760 Phase 1, Phase 2
39 PSA-Based Vaccine and Radiotherapy to Treat Localized Prostate Cancer Completed NCT00005916 Phase 2 rV-PSA;rF-PSA;rV-B7.1
40 Safety, Tolerability, Pharmacokinetics (PK) of the Anti-Orthopox Drug, ST-246 Completed NCT00907803 Phase 2 ST-246 400 mg;ST-246 600 mg;Placebo
41 Trial of a WT-1 Analog Peptide Vaccine in Patients With Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL) Active, not recruiting NCT01266083 Phase 2
42 Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination Terminated NCT00053508 Phase 2
43 Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in Adults Completed NCT00079820 Phase 1
44 Study of Reactogenicity, Safety, Immunogenicity, and Pock Lesion Formation of a Cell-Cultured Smallpox Vaccine Compared to Dryvax® Completed NCT00042094 Phase 1
45 Take Rate, Immunogenicity and Safety of Elstree-BN Smallpox Vaccine in Healthy Vaccinia-Naive Subjects Completed NCT00189969 Phase 1
46 Human Immune Responses Smallpox Completed NCT00068198 Phase 1
47 Safety and Immunogenicity of CJ-50300 Completed NCT00336635 Phase 1
48 A Comparative Phase I Clinical Study of HIVAC-1e and Smallpox (Vaccinia) Vaccines in Previously (Vaccinia) Vaccinated and Unvaccinated Volunteers Completed NCT00002261 Phase 1
49 Safety, Reactogenicity and Immunogenicity of MVA in Hematopoietic Stem Cell Transplant (HSCT) Subjects Completed NCT00565929 Phase 1 Placebo
50 Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in Patients With Atopic Disorders Completed NCT00189917 Phase 1

Search NIH Clinical Center for Smallpox

Cochrane evidence based reviews: smallpox

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Genetic Tests for Smallpox

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Anatomical Context for Smallpox

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The Foundational Model of Anatomy Ontology organs/tissues related to Smallpox:

19
Skin

MalaCards organs/tissues related to Smallpox:

41
Skin, T Cells, Testes, Eye, Myeloid, Prostate, Liver
Sources

Publications for Smallpox

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Articles related to Smallpox:

(show top 50) (show all 677)
# Title Authors Year
1
Challenges and Achievements in Prevention and Treatment of Smallpox. ( 29382130 )
2018
2
Oral Tecovirimat for the Treatment of Smallpox. ( 29972742 )
2018
3
Edward Jenner's 1798 report of challenge experiments demonstrating the protective effects of cowpox against smallpox. ( 29978749 )
2018
4
Immunogenicity and safety of three consecutive production lots of the non replicating smallpox vaccine MVA: A randomised, double blind, placebo controlled phase III trial. ( 29652929 )
2018
5
The geography of smallpox in England before vaccination: A conundrum resolved. ( 29684651 )
2018
6
E3L and F1L Gene Functions Modulate the Protective Capacity of Modified Vaccinia Virus Ankara Immunization in Murine Model of Human Smallpox. ( 29300297 )
2018
7
Myocarditis secondary to smallpox vaccination. ( 29572367 )
2018
8
Does smallpox vaccination modify HIV disease progression among ART-naive people living with HIV in Africa? ( 29235428 )
2018
9
How Valid Are Assumptions About Re-emerging Smallpox? A Systematic Review of Parameters Used in Smallpox Mathematical Models. ( 29425329 )
2018
10
Never Mind the Science, Here's the Convention on Biological Diversity: Viral Sovereignty in the Smallpox Destruction Debate. ( 29978646 )
2018
11
Influence of Population Immunosuppression and Past Vaccination on Smallpox Reemergence. ( 29553311 )
2018
12
Post-Smallpox Vaccination Skin Eruption in a Marine. ( 29546340 )
2018
13
Smallpox vaccine complications: the dermatologist's role in diagnosis and management. ( 29554163 )
2018
14
A Case Series of Smallpox Vaccination-Associated Myopericarditis: Effects on Safety and Readiness of the Active Duty Soldier. ( 29947793 )
2018
15
Equination (inoculation of horsepox): An early alternative to vaccination (inoculation of cowpox) and the potential role of horsepox virus in the origin of the smallpox vaccine. ( 29137821 )
2017
16
40 Years without Smallpox. ( 29340212 )
2017
17
Considering the "public" in public health: popular resistance to the Smallpox Eradication Programme in India. ( 28512076 )
2017
18
Successful treatment of smallpox scars by using radiofrequency device with single microneedle. ( 28547841 )
2017
19
George Boole, saucy little Alice and an uneventful smallpox vaccination: one of the greatest stories never told. ( 28235836 )
2017
20
Revisiting Jenner's mysteries, the role of the Beaugency lymph in the evolutionary path of ancient smallpox vaccines. ( 28827144 )
2017
21
Donald Ainslie (D.A.) Henderson, M.D., M.P.H. (1928 - 2016) Smallpox Eradication: Leadership and Legacy. ( 28170040 )
2017
22
Treacle and Smallpox: Two Tests for Multicriteria Decision Analysis Models in Health Technology Assessment. ( 28292498 )
2017
23
The Peace Gun and the Eradication of Smallpox. ( 28290922 )
2017
24
Humoral Immunity to Primary Smallpox Vaccination: Impact of Childhood versus Adult Immunization on Vaccinia Vector Vaccine Development in Military Populations. ( 28046039 )
2017
25
The Role of Brincidofovir in Preparation for a Potential Smallpox Outbreak. ( 29773767 )
2017
26
An Early American Smallpox Vaccine Based on Horsepox. ( 29020595 )
2017
27
Duration of neutralizing antibody persisting in Thai individuals after childhood vaccination against smallpox. ( 28577520 )
2017
28
Viral Evolution: Mummy Virus Challenges Presumed History of Smallpox. ( 28171759 )
2017
29
Smallpox vaccination: an early start of modern medicine in America. ( 28634531 )
2017
30
Al Rhazes and the Beginning of the End of Smallpox. ( 28492840 )
2017
31
Short-term clinical safety profile of brincidofovir: A favorable benefit-risk proposition in the treatment of smallpox. ( 28093339 )
2017
32
The De Novo Synthesis of Horsepox Virus: Implications for Biosecurity and Recommendations for Preventing the Reemergence of Smallpox. ( 28836863 )
2017
33
Characterization of Two Historic Smallpox Specimens from a Czech Museum. ( 28749451 )
2017
34
Improving the Care and Treatment of Monkeypox Patients in Low-Resource Settings: Applying Evidence from Contemporary Biomedical and Smallpox Biodefense Research. ( 29231870 )
2017
35
The last major outbreak of smallpox (Yugoslavia, 1972): The importance of historical reminders. ( 28545976 )
2017
36
Relocating Pastorian Medicine: Accommodation and Acclimatization of Pastorian Practices against Smallpox at the Pasteur Institute of Chengdu, China, 1908-1927. ( 28397646 )
2017
37
Smallpox (Variola) ( 29262186 )
2017
38
The Effect of Smallpox and Bacillus Calmette-GuAcrin Vaccination on the Risk of Human Immunodeficiency Virus-1 Infection in Guinea-Bissau and Denmark. ( 28852677 )
2017
39
Labmade smallpox is possible, study shows. ( 28706017 )
2017
40
Comparative Efficacy of Intramuscular and Scarification Routes of Administration of Live Smallpox Vaccine in a Murine Challenge Model. ( 28606813 )
2017
41
Comment: Characterization of Two Historic Smallpox Specimens from a Czech Museum. ( 28956829 )
2017
42
The Threat of Synthetic Smallpox: European Perspectives. ( 29178813 )
2017
43
Variola minor in coalfield areas of England and Wales, 1921-34: Geographical determinants of a national smallpox epidemic that spread out of effective control. ( 28351006 )
2017
44
Urban inoculation and the decline of smallpox mortality in eighteenth-century cities-a reply to Razzell. ( 26900169 )
2016
45
Position on reproductive donors andA smallpox vaccine: a committee opinion. ( 26829211 )
2016
46
Defending against smallpox: a focus on vaccines. ( 27049653 )
2016
47
Povidone Iodine Ointment Application to the Vaccination Site Does Not Alter Immunoglobulin G Antibody Response to Smallpox Vaccine. ( 27214505 )
2016
48
Vaccinations against smallpox and tuberculosis are associated with better long-term survival: a Danish case-cohort study 1971-2010. ( 27380797 )
2016
49
A New Document on Smallpox Vaccination. ( 28010829 )
2016
50
The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine. ( 27513748 )
2016
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Variations for Smallpox

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Expression for Smallpox

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Search GEO for disease gene expression data for Smallpox.
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Pathways for Smallpox

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Pathways related to Smallpox according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
PEDF Induced Signaling 64
Show member pathways
 13.62 CSF2 IFNG IL12RB2 IL18 IL18R1 IL2
2
TGF-Beta Pathway 64
Show member pathways
 13.45 IFNG IL12RB2 IL18 IL18R1 IL2 SPIRE1
3
Akt Signaling 64
Show member pathways
 13.35 CSF2 IL12RB2 IL18 IL18R1 IL2 PRKCQ
4
Cytokine Signaling in Immune system 66
Show member pathways
 13.27 CSF2 IFNG IL12RB2 IL18 IL18BP IL18R1
5
PAK Pathway 64
Show member pathways
 13.26 CSF2 IL12RB2 IL18 IL18R1 IL2 PRKCQ
6
Allograft rejection 1 37
Show member pathways
 12.78 IFNG IL12RB2 IL18 IL18R1 IL2 PRKCQ
7
Influenza A 37
Show member pathways
 12.74 IFNG IL18 IL2 PRKCQ TNF
8
Immune response IL-23 signaling pathway 22
Show member pathways
 12.54 IFNG IL18 IL18R1 IL2 TNF
9
NF-kappaB Signaling 4
12.51 GZMA IFNG IL2 PRKCQ TNF
10
Regulation of IFNA signaling 66
Show member pathways
 12.51 CSF2 IFNG IL12RB2 IL18 IL2 TNF
11
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.46 CSF2 IFNG IL2 PRKCQ TNF
12
T cell receptor signaling pathway 37
Show member pathways
 12.34 CSF2 IFNG IL2 PRKCQ TNF
13
IL-1 Family Signaling Pathways 65
Show member pathways
 12.19 IL18 IL18BP IL18R1 TNF
14
Th17 cell differentiation 37
Show member pathways
 12.12 IFNG IL12RB2 IL18 IL18R1 IL2 PRKCQ
15
Th1 Differentiation Pathway 65
Show member pathways
 12.07 IFNG IL12RB2 IL18 IL18R1 IL2 TNF
16
Spinal Cord Injury 1
11.94 IFNG IL2 TNF
17
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.93 CSF2 IFNG IL2 TNF
18
TNF signaling pathway 37
11.89 CSF2 IL18R1 TNF
19
Amoebiasis 37
11.83 CSF2 IFNG TNF
20
Corticotropin-releasing hormone signaling pathway 1
11.81 IL18 IL2 PRKCQ
21
Rheumatoid arthritis 37
11.78 CSF2 IFNG IL18 TNF
22
Salmonella infection (KEGG) 37
11.77 CSF2 IFNG IL18
23
Glucocorticoid receptor regulatory network 1
11.74 CSF2 IFNG IL2
24
Dendritic Cells Developmental Lineage Pathway 65
11.68 CSF2 IFNG IL2 TNF
25
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.58 CSF2 IFNG IL2 TNF
26
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.54 IFNG IL2 PRKCQ TNF
27
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.54 CSF2 IFNG IL2 PRKCQ TNF
28
Photodynamic therapy-induced AP-1 survival signaling. 1
11.52 IFNG IL2 TNF
29
Interleukin-10 signaling 66
11.5 CSF2 IL18 TNF
30
Malaria 37
11.49 IFNG IL18 TNF
31
IL12-mediated signaling events 1
Show member pathways
 11.49 GZMA IFNG IL12RB2 IL18 IL18R1 IL2
32
Aryl Hydrocarbon Receptor Pathway 1
11.48 IFNG IL2 TNF
33
MSP-RON Signaling 64
11.47 IFNG IL18 TNF
34
Th2 Differentiation Pathway 65
11.45 IFNG IL12RB2 IL2
35
African trypanosomiasis 37
11.31 IFNG IL18 TNF
36
Development and heterogeneity of the ILC family 1
11.26 IFNG IL18 TNF
37
Immune response_IL-12 signaling pathway 22
Show member pathways
 11.19 IFNG IL12RB2 IL18R1
38
Cytokines and Inflammatory Response 1
11.18 CSF2 IFNG IL2 TNF
39
IL12 signaling mediated by STAT4 1
11.12 IFNG IL18 IL18R1 IL2
40
Innate Lymphoid Cell Differentiation Pathways 65
11 GZMA IFNG IL12RB2 IL18 IL2 TNF
41
Hypertrophy Model 1
10.99 IFNG IL18
Sources

GO Terms for Smallpox

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Biological processes related to Smallpox according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.92 CSF2 IFNG IL18 IL2 TNF
2 MAPK cascade GO:0000165 9.87 CSF2 IL18 IL2 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.85 CSF2 IL12RB2 IL18 IL2 TNF
4 immune response GO:0006955 9.7 CSF2 GZMA IFNG IL18 IL18R1 IL2
5 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.65 IL18 IL18R1 TNF
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.62 CSF2 IFNG IL18 IL2
7 positive regulation of osteoclast differentiation GO:0045672 9.6 IFNG TNF
8 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 IFNG TNF
9 regulation of regulatory T cell differentiation GO:0045589 9.58 IFNG IL2
10 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.58 CSF2 IL18
11 interferon-gamma production GO:0032609 9.56 IL12RB2 IL18
12 positive regulation of podosome assembly GO:0071803 9.55 CSF2 TNF
13 T-helper 1 type immune response GO:0042088 9.54 IL18 IL18BP
14 natural killer cell activation GO:0030101 9.54 IL18 IL18R1 IL2
15 positive regulation of tissue remodeling GO:0034105 9.51 IL18 IL2
16 positive regulation of interleukin-23 production GO:0032747 9.49 CSF2 IFNG
17 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG TNF
18 positive regulation of interleukin-17 production GO:0032740 9.43 IL18 IL2 PRKCQ
19 positive regulation of vitamin D biosynthetic process GO:0060557 9.4 IFNG TNF
20 interleukin-18-mediated signaling pathway GO:0035655 9.13 IL18 IL18BP IL18R1
21 positive regulation of interferon-gamma production GO:0032729 9.02 IL12RB2 IL18 IL18R1 IL2 TNF

Molecular functions related to Smallpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CSF2 IFNG IL18 IL2 TNF
Sources

Sources for Smallpox

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
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28 GO
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The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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