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MCID: SML019
MIFTS: 58

Smallpox

Categories: Immune diseases, Infectious diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Smallpox

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MalaCards integrated aliases for Smallpox:

Name: Smallpox 12 76 53 55 43 3 44 15 73
Ordinary Smallpox 12
Variola 53

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Skin diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:8736
ICD10 33 B03
ICD9CM 35 050 050.9
MeSH 44 D012899
NCIt 50 C35027
SNOMED-CT 68 47452006 67924001
UMLS 73 C0037354
Sources

Summaries for Smallpox

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MedlinePlus : 43 Smallpox is a disease caused by the Variola major virus. Some experts say that over the centuries it has killed more people than all other infectious diseases combined. Worldwide immunization stopped the spread of smallpox three decades ago. The last case was reported in 1977. Two research labs still keep small amounts of the virus. Experts fear bioterrorists could use the virus to spread disease. Smallpox spreads very easily from person to person. Symptoms are flu-like. They include High fever Fatigue Headache Backache A rash with flat red sores There is no treatment. Fluids and medicines for pain or fever can help control symptoms. Most people recover, but some can die. Those who do recover may have severe scars. The U.S. stopped routine smallpox vaccinations in 1972. Military and other high-risk groups continue to get the vaccine. The U.S. has increased its supply of the vaccine in recent years. The vaccine makes some people sick, so doctors save it for those at highest risk of disease. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Smallpox, also known as ordinary smallpox, is related to variola major and viral infectious disease, and has symptoms including fever, pruritus and exanthema. An important gene associated with Smallpox is IL18R1 (Interleukin 18 Receptor 1), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and prostate, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in Variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. The infection results in formation of lesions, first on the face, hands and forearms and later on the trunk.

CDC : 3 Thousands of years ago, variola virus (smallpox virus) emerged and began causing illness and deaths in human populations, with smallpox outbreaks occurring from time to time. Thanks to the success of vaccination, the last natural outbreak of smallpox in the United States occurred in 1949. In 1980, the World Health Assembly declared smallpox eradicated (eliminated), and no cases of naturally occurring smallpox have happened since. 

Wikipedia : 76 Smallpox was an infectious disease caused by one of two virus variants, variola major and variola minor.... more...

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Related Diseases for Smallpox

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Diseases related to Smallpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 variola major 33.4 IFNG IL2
2 viral infectious disease 32.2 IFNG IL2 TNF
3 erythema multiforme 29.8 IFNG IL2 TNF
4 human immunodeficiency virus infectious disease 29.8 IFNG IL2 TNF
5 schistosomiasis 29.8 IFNG IL2 TNF
6 dermatitis, atopic 29.8 CSF2 IFNG IL18 IL2 TNF
7 acquired immunodeficiency syndrome 29.8 CSF2 IFNG IL2 TNF
8 arthritis 29.6 CSF2 IFNG IL18 TNF
9 inflammatory bowel disease 29.3 IFNG IL12RB2 IL18 IL18R1 IL2 TNF
10 cowpox 11.7
11 vaccinia 11.5
12 variola minor 11.5
13 monkeypox 11.4
14 chickenpox 10.3
15 staphylococcal toxic shock syndrome 10.2 IFNG TNF
16 autoimmune myocarditis 10.2 IFNG TNF
17 chronic beryllium disease 10.2 IFNG TNF
18 oral tuberculosis 10.2 IL2 TNF
19 fixed drug eruption 10.2 IFNG IL2
20 myocarditis 10.2
21 berylliosis 10.2 IFNG IL2
22 mycoplasma pneumoniae pneumonia 10.2 IFNG IL18 TNF
23 pleural tuberculosis 10.2 IFNG IL18 TNF
24 rasmussen encephalitis 10.2 IFNG IL18 TNF
25 scleritis 10.2 IFNG TNF
26 melioidosis 10.2 IFNG IL18 TNF
27 lymphadenitis 10.2 IFNG IL18 TNF
28 anthracosis 10.2 IL18R1 TNF
29 gillessen-kaesbach-nishimura syndrome 10.2 IL18 IL18BP
30 plasmodium falciparum malaria 10.2 IFNG IL18 TNF
31 relapsing-remitting multiple sclerosis 10.2 IFNG IL18 TNF
32 uremic pruritus 10.2 IL18 IL2
33 streptococcal toxic-shock syndrome 10.2 IL2 TNF
34 proteasome-associated autoinflammatory syndrome 1 10.2 IFNG IL18 TNF
35 large granular lymphocyte leukemia 10.2 CSF2 IFNG
36 farmer's lung 10.2 IL2 TNF
37 rheumatic disease 10.1 IFNG IL18 TNF
38 atopic keratoconjunctivitis 10.1 IFNG IL2
39 mycobacterium tuberculosis 1 10.1 IFNG IL18 TNF
40 clonorchiasis 10.1 IFNG IL2 TNF
41 crohn's colitis 10.1 IFNG IL2 TNF
42 intermediate uveitis 10.1 IFNG IL2 TNF
43 posterior uveitis 10.1 IFNG IL2 TNF
44 coccidiosis 10.1 IFNG IL2 TNF
45 hemophagocytic lymphohistiocytosis 10.1 IFNG IL18 TNF
46 hematopoietic stem cell transplantation 10.1 IFNG IL2 TNF
47 hypersensitivity reaction type iv disease 10.1 IFNG IL2 TNF
48 cardiac sarcoidosis 10.1 IFNG TNF
49 mucormycosis 10.1 CSF2 IFNG
50 autoimmune uveitis 10.1 IFNG IL2 TNF

Graphical network of the top 20 diseases related to Smallpox:



Diseases related to Smallpox
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Symptoms & Phenotypes for Smallpox

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UMLS symptoms related to Smallpox:


fever, pruritus, exanthema

MGI Mouse Phenotypes related to Smallpox:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.06 CSF2 GOLGA3 GZMA IFNG IL12RB2 IL18
2 homeostasis/metabolism MP:0005376 10.03 CSF2 CSMD1 GOLGA3 GPR158 IFNG IL12RB2
3 endocrine/exocrine gland MP:0005379 9.97 CSF2 GOLGA3 IFNG IL12RB2 IL18BP IL2
4 immune system MP:0005387 9.85 CSF2 GZMA IFNG IL12RB2 IL18 IL18BP
5 neoplasm MP:0002006 9.5 CSF2 GZMA IFNG IL12RB2 IL2 PRKCQ
6 reproductive system MP:0005389 9.23 CSF2 GOLGA3 IFNG IL18BP IL2 PRKCQ
Sources

Drugs & Therapeutics for Smallpox

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Drugs for Smallpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
2 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
3 Immunoglobulins, Intravenous Phase 4,Phase 2,Phase 1
4 gamma-Globulins Phase 4,Phase 2,Phase 1
5 Antibodies Phase 4,Phase 2,Phase 1
6 Immunoglobulins Phase 4,Phase 2,Phase 1
7 Rho(D) Immune Globulin Phase 4,Phase 2,Phase 1
8 Iron-Dextran Complex Phase 3
9
Phenol Approved, Experimental Phase 2 108-95-2 996
10
Benzocaine Approved, Investigational Phase 1, Phase 2 94-09-7, 1994-09-7 2337
11 tannic acid Approved Phase 1, Phase 2
12
Mannitol Approved, Investigational Phase 1 69-65-8 453 6251
13 Pharmaceutical Solutions Phase 1
14 Natriuretic Agents Phase 1
15 diuretics Phase 1
16 interferons Phase 1
17 Krestin Phase 1
18 Protective Agents Phase 1
19 Antibiotics, Antitubercular Phase 1
20 Radiation-Protective Agents Phase 1
21 Antiviral Agents Phase 1
22 Anti-Bacterial Agents Phase 1
23 Adjuvants, Immunologic Phase 1
24 Anti-Infective Agents Phase 1
25 Interferon Inducers Phase 1
26 Keyhole-limpet hemocyanin Phase 1
27 Liver Extracts Phase 1
28 Cathartics Phase 1
29 Carboxymethylcellulose Sodium Phase 1
30 Poly ICLC Phase 1
31 Laxatives Phase 1
32 Poly I-C Phase 1
33 Gastrointestinal Agents Phase 1
34 Interferon-gamma

Interventional clinical trials:

(show top 50) (show all 85)
# Name Status NCT ID Phase Drugs
1 Vaccinia Vaccine (ACAM2000) for the Production of Vaccinia Immune Globulin Intravenous(VIGIV) Completed NCT01158157 Phase 4
2 Special Access Program IMVAMUNE® Completed NCT03472014 Phase 4
3 VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIV Recruiting NCT02443623 Phase 4
4 Safety and Efficacy of CJ Smallpox Vaccine in Previously Vaccinated Healthy Volunteers Completed NCT01317238 Phase 3 smallpox vaccine CJ-50300
5 Safety and Efficacy of CJ Smallpox Vaccine in Healthy Volunteers Completed NCT01056770 Phase 3 smallpox vaccine CJ-50300
6 A Trial to Evaluate Immunogenicity and Safety of Three Consecutive Production Lots of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in Healthy, Vaccinia-naïve Subjects Completed NCT01144637 Phase 3
7 Safety and Efficacy of CJ-50300 in Healthy Volunteers Completed NCT00607243 Phase 2, Phase 3
8 A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound Tecovirimat Completed NCT02474589 Phase 3 tecovirimat
9 IMVAMUNE® Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the Congo Recruiting NCT02977715 Phase 3
10 A Non-inferiority Trial to Compare MVA-BN® Smallpox Vaccine to ACAM2000® Active, not recruiting NCT01913353 Phase 3
11 Freeze-Dried MVA-BN® Lot Consistency Smallpox Trial Not yet recruiting NCT03699124 Phase 3
12 Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated Volunteers Unknown status NCT00103584 Phase 1, Phase 2
13 Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection Completed NCT02038881 Phase 2
14 Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination Completed NCT00053495 Phase 2
15 Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated Adults Completed NCT00053482 Phase 2
16 Phase 2 Study of Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Smallpox Vaccine Completed NCT00466245 Phase 2 MVA Smallpox vaccine;Placebo
17 Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young Adults Completed NCT00258947 Phase 2
18 Dressing Preparations for Smallpox Completed NCT00063856 Phase 1, Phase 2
19 A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy Subjects Completed NCT01668537 Phase 2
20 APSV in Vaccinia Naive Adults Completed NCT00050518 Phase 2
21 Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE® Completed NCT01827371 Phase 2
22 A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced Subjects Completed NCT00857493 Phase 2
23 Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine. Completed NCT00189956 Phase 2
24 A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults Completed NCT00026611 Phase 2
25 A Randomized, Double-blind, Placebo-controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE™) Smallpox Vaccine in Healthy Subjects Completed NCT00316524 Phase 2
26 MVA Post-Event: Administration Timing and Boost Study Completed NCT00437021 Phase 1, Phase 2 Placebo (subcutaneous);Placebo (scarification)
27 Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered Intradermally Completed NCT00914732 Phase 2
28 Expanded Dryvax Dilution Study in Previously Vaccinated Adults Completed NCT00050505 Phase 2
29 ACAM 3000 MVA at Harvard Medical School Completed NCT00133575 Phase 1, Phase 2
30 Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected Patients Completed NCT00316589 Phase 2
31 A Phase II Study on Immunogenicity and Safety of MVA-BN® (IMVAMUNE™) Smallpox Vaccine in Subjects With Atopic Dermatitis Completed NCT00316602 Phase 2
32 Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in HIV Infected Patients Completed NCT00189904 Phase 1, Phase 2
33 Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOT Completed NCT00038987 Phase 1, Phase 2
34 High Dose IMVAMUNE® in Vaccinia-Naive Individuals Completed NCT00879762 Phase 2 Placebo
35 Dryvax Dilution-Prev Vacc Adults Completed NCT00032708 Phase 2
36 An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 Vaccinees Completed NCT00686582 Phase 2
37 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2 NP-016 Vaccine Immune Globulin (IV-VIG)
38 Immune Response to Yellow Fever Vaccination in Adults With Atopic Dermatitis Completed NCT00723489 Phase 1, Phase 2 YFV-17D Placebo
39 A Study to Assess the Effectiveness of a New Malaria Vaccine Candidate by Infecting Vaccinated Volunteers With Malaria Parasites Completed NCT00890760 Phase 1, Phase 2
40 PSA-Based Vaccine and Radiotherapy to Treat Localized Prostate Cancer Completed NCT00005916 Phase 2 rV-PSA;rF-PSA;rV-B7.1
41 Safety, Tolerability, Pharmacokinetics (PK) of the Anti-Orthopox Drug, ST-246 Completed NCT00907803 Phase 2 ST-246 400 mg;ST-246 600 mg;Placebo
42 EMaBS TB Vaccine Study Not yet recruiting NCT03681860 Phase 1, Phase 2
43 Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination Terminated NCT00053508 Phase 2
44 Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in Adults Completed NCT00079820 Phase 1
45 Study of Reactogenicity, Safety, Immunogenicity, and Pock Lesion Formation of a Cell-Cultured Smallpox Vaccine Compared to Dryvax® Completed NCT00042094 Phase 1
46 Take Rate, Immunogenicity and Safety of Elstree-BN Smallpox Vaccine in Healthy Vaccinia-Naive Subjects Completed NCT00189969 Phase 1
47 Human Immune Responses Smallpox Completed NCT00068198 Phase 1
48 Safety and Immunogenicity of CJ-50300 Completed NCT00336635 Phase 1
49 A Comparative Phase I Clinical Study of HIVAC-1e and Smallpox (Vaccinia) Vaccines in Previously (Vaccinia) Vaccinated and Unvaccinated Volunteers Completed NCT00002261 Phase 1
50 Safety, Reactogenicity and Immunogenicity of MVA in Hematopoietic Stem Cell Transplant (HSCT) Subjects Completed NCT00565929 Phase 1 Placebo

Search NIH Clinical Center for Smallpox

Cochrane evidence based reviews: smallpox

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Genetic Tests for Smallpox

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Anatomical Context for Smallpox

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MalaCards organs/tissues related to Smallpox:

41
Skin, T Cells, Prostate, Testes, Heart, Bone, Lung
Sources

Publications for Smallpox

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Articles related to Smallpox:

(show top 50) (show all 1048)
# Title Authors Year
1
Monkeypox - Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era. ( 30453097 )
2019
2
Challenges and Achievements in Prevention and Treatment of Smallpox. ( 29382130 )
2018
3
Oral Tecovirimat for the Treatment of Smallpox. ( 29972742 )
2018
4
Edward Jenner's 1798 report of challenge experiments demonstrating the protective effects of cowpox against smallpox. ( 29978749 )
2018
5
Immunogenicity and safety of three consecutive production lots of the non replicating smallpox vaccine MVA: A randomised, double blind, placebo controlled phase III trial. ( 29652929 )
2018
6
The geography of smallpox in England before vaccination: A conundrum resolved. ( 29684651 )
2018
7
E3L and F1L Gene Functions Modulate the Protective Capacity of Modified Vaccinia Virus Ankara Immunization in Murine Model of Human Smallpox. ( 29300297 )
2018
8
Myocarditis secondary to smallpox vaccination. ( 29572367 )
2018
9
Does smallpox vaccination modify HIV disease progression among ART-naive people living with HIV in Africa? ( 29235428 )
2018
10
How Valid Are Assumptions About Re-emerging Smallpox? A Systematic Review of Parameters Used in Smallpox Mathematical Models. ( 29425329 )
2018
11
Never Mind the Science, Here's the Convention on Biological Diversity: Viral Sovereignty in the Smallpox Destruction Debate. ( 29978646 )
2018
12
Influence of Population Immunosuppression and Past Vaccination on Smallpox Reemergence. ( 29553311 )
2018
13
Post-Smallpox Vaccination Skin Eruption in a Marine. ( 29546340 )
2018
14
Smallpox vaccine complications: the dermatologist's role in diagnosis and management. ( 29554163 )
2018
15
A Case Series of Smallpox Vaccination-Associated Myopericarditis: Effects on Safety and Readiness of the Active Duty Soldier. ( 29947793 )
2018
16
Beyond the myths: Novel findings for old paradigms in the history of the smallpox vaccine. ( 30048524 )
2018
17
An antiviral for smallpox. ( 30082865 )
2018
18
Smallpox Autoinoculation Via Tattoo in a Soldier. ( 30085282 )
2018
19
Bayesian Phylogeography and Pathogenic Characterization of Smallpox Based on HA, ATI, and CrmB Genes. ( 30099520 )
2018
20
The spectre of smallpox lingers. ( 30104592 )
2018
21
First Smallpox Drug Approved. ( 30140861 )
2018
22
Smallpox antiviral ends decades-long search. ( 30188546 )
2018
23
Drug Approved to Treat Smallpox After a Bioterrorist Attack. ( 30358593 )
2018
24
Long-term effects of smallpox vaccination on expression of the HIV-1 co-receptor CCR5 in women. ( 30440008 )
2018
25
Oral Tecovirimat for the Treatment of Smallpox. ( 30462945 )
2018
26
Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox - Part II. ( 30488769 )
2018
27
The last case of smallpox. ( 30507458 )
2018
28
Equination (inoculation of horsepox): An early alternative to vaccination (inoculation of cowpox) and the potential role of horsepox virus in the origin of the smallpox vaccine. ( 29137821 )
2017
29
40 Years without Smallpox. ( 29340212 )
2017
30
Considering the "public" in public health: popular resistance to the Smallpox Eradication Programme in India. ( 28512076 )
2017
31
Successful treatment of smallpox scars by using radiofrequency device with single microneedle. ( 28547841 )
2017
32
George Boole, saucy little Alice and an uneventful smallpox vaccination: one of the greatest stories never told. ( 28235836 )
2017
33
Revisiting Jenner's mysteries, the role of the Beaugency lymph in the evolutionary path of ancient smallpox vaccines. ( 28827144 )
2017
34
Donald Ainslie (D.A.) Henderson, M.D., M.P.H. (1928 - 2016) Smallpox Eradication: Leadership and Legacy. ( 28170040 )
2017
35
Treacle and Smallpox: Two Tests for Multicriteria Decision Analysis Models in Health Technology Assessment. ( 28292498 )
2017
36
The Peace Gun and the Eradication of Smallpox. ( 28290922 )
2017
37
Humoral Immunity to Primary Smallpox Vaccination: Impact of Childhood versus Adult Immunization on Vaccinia Vector Vaccine Development in Military Populations. ( 28046039 )
2017
38
The Role of Brincidofovir in Preparation for a Potential Smallpox Outbreak. ( 29773767 )
2017
39
An Early American Smallpox Vaccine Based on Horsepox. ( 29020595 )
2017
40
Duration of neutralizing antibody persisting in Thai individuals after childhood vaccination against smallpox. ( 28577520 )
2017
41
Viral Evolution: Mummy Virus Challenges Presumed History of Smallpox. ( 28171759 )
2017
42
Smallpox vaccination: an early start of modern medicine in America. ( 28634531 )
2017
43
Al Rhazes and the Beginning of the End of Smallpox. ( 28492840 )
2017
44
Short-term clinical safety profile of brincidofovir: A favorable benefit-risk proposition in the treatment of smallpox. ( 28093339 )
2017
45
The De Novo Synthesis of Horsepox Virus: Implications for Biosecurity and Recommendations for Preventing the Reemergence of Smallpox. ( 28836863 )
2017
46
Characterization of Two Historic Smallpox Specimens from a Czech Museum. ( 28749451 )
2017
47
Improving the Care and Treatment of Monkeypox Patients in Low-Resource Settings: Applying Evidence from Contemporary Biomedical and Smallpox Biodefense Research. ( 29231870 )
2017
48
The last major outbreak of smallpox (Yugoslavia, 1972): The importance of historical reminders. ( 28545976 )
2017
49
Relocating Pastorian Medicine: Accommodation and Acclimatization of Pastorian Practices against Smallpox at the Pasteur Institute of Chengdu, China, 1908-1927. ( 28397646 )
2017
50
Smallpox (Variola) ( 29262186 )
2017
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Variations for Smallpox

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Expression for Smallpox

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Search GEO for disease gene expression data for Smallpox.
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Pathways for Smallpox

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Pathways related to Smallpox according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
PEDF Induced Signaling 64
Show member pathways
 13.62 CSF2 IFNG IL12RB2 IL18 IL18R1 IL2
2
Akt Signaling 64
Show member pathways
 13.36 CSF2 IL12RB2 IL18 IL18R1 IL2 PRKCQ
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.27 CSF2 IFNG IL12RB2 IL18 IL18BP IL18R1
4
PAK Pathway 64
Show member pathways
 13.26 CSF2 IL12RB2 IL18 IL18R1 IL2 PRKCQ
5
Allograft rejection 1 37
Show member pathways
 12.79 IFNG IL12RB2 IL18 IL18R1 IL2 PRKCQ
6
Influenza A 37
Show member pathways
 12.74 IFNG IL18 IL2 PRKCQ TNF
7
Immune response IL-23 signaling pathway 22
Show member pathways
 12.54 IFNG IL18 IL18R1 IL2 TNF
8
Immune response NFAT in immune response 22
Show member pathways
 12.53 IFNG IL12RB2 IL18 IL18R1 IL2 PRKCQ
9
NF-kappaB Signaling 4
12.52 GZMA IFNG IL2 PRKCQ TNF
10
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.47 CSF2 IFNG IL2 PRKCQ TNF
11
Th17 cell differentiation 37
Show member pathways
 12.45 IFNG IL12RB2 IL18 IL18R1 IL2 PRKCQ
12
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.35 CSF2 IFNG IL12RB2 IL2
13
T cell receptor signaling pathway 37
Show member pathways
 12.35 CSF2 IFNG IL2 PRKCQ TNF
14
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.2 IFNG IL18 IL2 TNF
15
IL-1 Family Signaling Pathways 65
Show member pathways
 12.19 IL18 IL18BP IL18R1 TNF
16
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 11.97 CSF2 IFNG TNF
17
Spinal Cord Injury 1
11.94 IFNG IL2 TNF
18
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.94 CSF2 IFNG IL2 TNF
19
TNF signaling pathway 37
11.9 CSF2 IL18R1 TNF
20
Amoebiasis 37
11.83 CSF2 IFNG TNF
21
Corticotropin-releasing hormone signaling pathway 1
11.82 IL18 IL2 PRKCQ
22
Jak-Stat Signaling Pathway (sino) 67
11.81 IFNG IL12RB2 IL2
23
Rheumatoid arthritis 37
11.79 CSF2 IFNG IL18 TNF
24
Salmonella infection (KEGG) 37
11.78 CSF2 IFNG IL18
25
Glucocorticoid receptor regulatory network 1
11.75 CSF2 IFNG IL2
26
Th1 Differentiation Pathway 65
Show member pathways
 11.75 IFNG IL12RB2 IL18 IL18R1 IL2 TNF
27
Dendritic Cells Developmental Lineage Pathway 65
11.69 CSF2 IFNG IL2 TNF
28
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 CSF2 IFNG IL2 TNF
29
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.6 CSF2 IFNG IL2 PRKCQ TNF
30
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.56 IFNG IL2 PRKCQ TNF
31
Photodynamic therapy-induced AP-1 survival signaling. 1
11.53 IFNG IL2 TNF
32
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.51 CSF2 IFNG IL18 IL2 TNF
33
Interleukin-10 signaling 66
11.5 CSF2 IL18 TNF
34
Malaria 37
11.5 IFNG IL18 TNF
35
Aryl Hydrocarbon Receptor Pathway 1
11.49 IFNG IL2 TNF
36
IL12-mediated signaling events 1
Show member pathways
 11.49 GZMA IFNG IL12RB2 IL18 IL18R1 IL2
37
MSP-RON Signaling 64
11.48 IFNG IL18 TNF
38
Th2 Differentiation Pathway 65
11.46 IFNG IL12RB2 IL2
39
African trypanosomiasis 37
11.32 IFNG IL18 TNF
40
Development and heterogeneity of the ILC family 1
11.27 IFNG IL18 TNF
41
Cytokines and Inflammatory Response 1
11.22 CSF2 IFNG IL2 TNF
42
Immune response_IL-12 signaling pathway 22
Show member pathways
 11.21 IFNG IL12RB2 IL18R1
43
G-protein signaling_RhoB regulation pathway 22
11.19 CSF2 IL18 IL2 TNF
44
IL12 signaling mediated by STAT4 1
11.15 IFNG IL18 IL18R1 IL2
45
Hypertrophy Model 1
11 IFNG IL18
46
Innate Lymphoid Cell Differentiation Pathways 65
11 GZMA IFNG IL12RB2 IL18 IL2 TNF
Sources

GO Terms for Smallpox

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Biological processes related to Smallpox according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.96 CSF2 IFNG IL18 IL2 TNF
2 MAPK cascade GO:0000165 9.87 CSF2 IL18 IL2 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.83 CSF2 IL12RB2 IL18 IL2 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.78 IL18 IL18R1 PRKCQ TNF
5 positive regulation of inflammatory response GO:0050729 9.76 IL18 IL2 TNF
6 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.7 IL18 IL18R1 TNF
7 immune response GO:0006955 9.7 CSF2 GZMA IFNG IL18 IL18R1 IL2
8 positive regulation of osteoclast differentiation GO:0045672 9.62 IFNG TNF
9 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.62 CSF2 IL18
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.62 CSF2 IFNG IL18 IL2
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IFNG TNF
12 regulation of regulatory T cell differentiation GO:0045589 9.61 IFNG IL2
13 interferon-gamma production GO:0032609 9.6 IL12RB2 IL18
14 positive regulation of podosome assembly GO:0071803 9.59 CSF2 TNF
15 T-helper 1 type immune response GO:0042088 9.58 IL18 IL18BP
16 natural killer cell activation GO:0030101 9.58 IL18 IL18R1 IL2
17 positive regulation of neuroinflammatory response GO:0150078 9.55 IL18 TNF
18 positive regulation of tissue remodeling GO:0034105 9.54 IL18 IL2
19 positive regulation of interleukin-23 production GO:0032747 9.51 CSF2 IFNG
20 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.49 IL18 IL18R1
21 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 IFNG TNF
22 positive regulation of interleukin-17 production GO:0032740 9.43 IL18 IL2 PRKCQ
23 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 IFNG TNF
24 interleukin-18-mediated signaling pathway GO:0035655 9.13 IL18 IL18BP IL18R1
25 positive regulation of interferon-gamma production GO:0032729 9.02 IL12RB2 IL18 IL18R1 IL2 TNF

Molecular functions related to Smallpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CSF2 IFNG IL18 IL2 TNF
2 interleukin-18 binding GO:0042007 8.96 IL18BP IL18R1
Sources

Sources for Smallpox

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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