SQTL3
MCID: SMK004
MIFTS: 46

Smoking As a Quantitative Trait Locus 3 (SQTL3)

Categories: Cancer diseases, Genetic diseases, Respiratory diseases

Aliases & Classifications for Smoking As a Quantitative Trait Locus 3

MalaCards integrated aliases for Smoking As a Quantitative Trait Locus 3:

Name: Smoking As a Quantitative Trait Locus 3 57 29 6
Lung Cancer Susceptibility 2 57 13 6 73
Nicotine Dependence 57 73
Nicotine Dependence, Susceptibility to 57
Sqtl3 57

Classifications:



External Ids:

OMIM 57 612052

Summaries for Smoking As a Quantitative Trait Locus 3

MalaCards based summary : Smoking As a Quantitative Trait Locus 3, also known as lung cancer susceptibility 2, is related to tobacco addiction and substance dependence. An important gene associated with Smoking As a Quantitative Trait Locus 3 is CHRNA3 (Cholinergic Receptor Nicotinic Alpha 3 Subunit), and among its related pathways/superpathways are Transmission across Chemical Synapses and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. Affiliated tissues include testes, brain and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Description from OMIM: 612052

Related Diseases for Smoking As a Quantitative Trait Locus 3

Graphical network of the top 20 diseases related to Smoking As a Quantitative Trait Locus 3:



Diseases related to Smoking As a Quantitative Trait Locus 3

Symptoms & Phenotypes for Smoking As a Quantitative Trait Locus 3

Clinical features from OMIM:

612052

GenomeRNAi Phenotypes related to Smoking As a Quantitative Trait Locus 3 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.28 CHRNA3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.28 CHRNA3
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.28 CHRNA5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.28 CHRNA5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.28 CHRNA3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.28 CHRNA5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.28 CHRNA3 CHRNA5
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.28 CHRNA5

Drugs & Therapeutics for Smoking As a Quantitative Trait Locus 3

Search Clinical Trials , NIH Clinical Center for Smoking As a Quantitative Trait Locus 3

Genetic Tests for Smoking As a Quantitative Trait Locus 3

Genetic tests related to Smoking As a Quantitative Trait Locus 3:

# Genetic test Affiliating Genes
1 Smoking As a Quantitative Trait Locus 3 29 CHRNA3 CHRNA5

Anatomical Context for Smoking As a Quantitative Trait Locus 3

MalaCards organs/tissues related to Smoking As a Quantitative Trait Locus 3:

41
Testes, Brain, Lung, Endothelial, Heart, Skin, Liver

Publications for Smoking As a Quantitative Trait Locus 3

Articles related to Smoking As a Quantitative Trait Locus 3:

(show top 50) (show all 1006)
# Title Authors Year
1
Correlates of nicotine dependence in men with childhood attention-deficit/hyperactivity disorder: a 33-year follow-up. ( 30171588 )
2018
2
Probability and correlates of nicotine dependence among smokers with and without major depressive disorder: Results from the national epidemiology survey on alcohol and related conditions. ( 29350765 )
2018
3
Is There an Association Between the Degree of Nicotine Dependence and the Motivation to Stop Smoking? ( 30316531 )
2018
4
An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse. ( 30345354 )
2018
5
Drug Addiction: Mechanisms of Nicotine Dependence Unmasked by Gene Editing. ( 30352192 )
2018
6
Association and cis-mQTL analysis of variants in serotonergic genes associated with nicotine dependence in Chinese Han smokers. ( 30405098 )
2018
7
Use of the Fagerström test to assess differences in the degree of nicotine dependence in smokers from five ethnic groups: The HELIUS study. ( 30447512 )
2018
8
Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence. ( 30453884 )
2018
9
A Comparison of Gender Differences in Smoking Behaviors, Intention to Quit, and Nicotine Dependence among Thai University Students. ( 30473903 )
2018
10
Prevalence of Nicotine Dependence among Men Aged 21-60 Years in the Rural Field Practice Area of a Tertiary Care Hospital in Tamil Nadu, India. ( 30474006 )
2018
11
Considerations when selecting pharmacotherapy for nicotine dependence. ( 30496692 )
2018
12
Age of tobacco use initiation and association with current use and nicotine dependence among US middle and high school students, 2014-2016. ( 30498008 )
2018
13
Gray matter volumes of insular subregions are not correlated with smoking cessation outcomes but negatively correlated with nicotine dependence severity in chronic smokers. ( 30543846 )
2018
14
Understanding Nicotine Dependence and Addiction Among Young Adults Who Smoke Cigarillos: A Qualitative Study. ( 28184877 )
2018
15
Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. ( 28290528 )
2018
16
Elevated Nicotine Dependence Scores among Electronic Cigarette Users at an Electronic Cigarette Convention. ( 28681280 )
2018
17
Evaluating the mutual pathways among electronic cigarette use, conventional smoking and nicotine dependence. ( 28841780 )
2018
18
Nicotine dependence, internalizing symptoms, mood variability and daily tobacco use among young adult smokers. ( 28943065 )
2018
19
Transitioning from adequate to inadequate sleep duration associated with higher smoking rate and greater nicotine dependence in a population sample. ( 28950118 )
2018
20
Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence. ( 28972577 )
2018
21
The Role of Nicotine Dependence in E-Cigarettes' Potential for Smoking Reduction. ( 29065204 )
2018
22
Effects of Negative Affect, Urge to Smoke, and Working Memory Performance (n-back) on Nicotine Dependence. ( 29185837 )
2018
23
Psychometric evaluation of the Patient-Reported Outcomes Measurement Information System (PROMIS) Nicotine Dependence Item Bank for use with electronic cigarettes. ( 29301008 )
2018
24
Nicotine dependence in Croatian male inpatients with schizophrenia. ( 29357830 )
2018
25
Integrative Data Analysis of Gender and Ethnic Measurement Invariance in Nicotine Dependence Symptoms. ( 29396761 )
2018
26
Is the Fagerström test for nicotine dependence invariant across secular trends in smoking? A question for cross-birth cohort analysis of nicotine dependence. ( 29438887 )
2018
27
Not all smokers appear to seek nicotine for the same reasons: implications for preclinical research in nicotine dependence. ( 29480575 )
2018
28
Preclinical evidence for combining the 5-HT2C receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence. ( 29498158 )
2018
29
Perception of Lung Cancer Risk: Impact of Smoking Status and Nicotine Dependence. ( 29508085 )
2018
30
Sex differences in attaining cigarette smoking and nicotine dependence milestones in novice smokers. ( 29522067 )
2018
31
Analyzing the pathways enriched in genes associated with nicotine dependence in the context of human protein-protein interaction network. ( 29546796 )
2018
32
Associations between opioid and nicotine dependence in nationally representative samples of United States adult daily smokers. ( 29579724 )
2018
33
The Effects of Nicotine and Tobacco use on Brain Reward Function: Interaction with Nicotine Dependence Severity. ( 29584917 )
2018
34
The latent trait of ICD-11 nicotine dependence criteria: Dimensional and categorical phenotypes. ( 29605101 )
2018
35
E-cigarette- specific symptoms of nicotine dependence among Texas adolescents. ( 29627634 )
2018
36
Work Stress and Depressive Symptoms in Fishermen With a Smoking Habit: A Mediator Role of Nicotine Dependence and Possible Moderator Role of Expressive Suppression and Cognitive Reappraisal. ( 29632504 )
2018
37
Differences in nicotine dependence, smoke exposure and consumer characteristics between smokers of machine-injected roll-your-own cigarettes and factory-made cigarettes. ( 29655031 )
2018
38
Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population. ( 29666375 )
2018
39
Nicotine dependence predicts cannabis use disorder symptoms among adolescents and young adults. ( 29680677 )
2018
40
Cancer Patients Enrolled in a Smoking Cessation Clinical Trial: Characteristics and Correlates of Smoking Rate and Nicotine Dependence. ( 29682394 )
2018
41
Income as a moderator of psychological stress and nicotine dependence among adult smokers. ( 29729584 )
2018
42
Assessing nicotine dependence in adolescent E-cigarette users: The 4-item Patient-Reported Outcomes Measurement Information System (PROMIS) Nicotine Dependence Item Bank for electronic cigarettes. ( 29753155 )
2018
43
The Role of CYP2A6 Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers. ( 29875862 )
2018
44
Brain Structure Alterations in Respect to Tobacco Consumption and Nicotine Dependence: A Comparative Voxel-Based Morphometry Study. ( 29881337 )
2018
45
The association between nicotine dependence and physical health among people receiving injectable diacetylmorphine or hydromorphone for the treatment of chronic opioid use disorder. ( 29892701 )
2018
46
Determinants of progression of nicotine dependence symptoms in adolescent waterpipe smokers. ( 29895703 )
2018
47
Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study. ( 29901032 )
2018
48
Associations Between Secondhand Tobacco Smoke Exposure and Nicotine Dependence and Smoking Cessation Attempts Among Adult Tobacco Users With a Psychiatric Disorder. ( 29902928 )
2018
49
Investigating the dimensional diagnosis of ICD-11 nicotine dependence. ( 29927280 )
2018
50
Effect of nicotine dependence on quality of life and sleep quality in patients with lung cancer who continue to smoke after diagnosis. ( 29997919 )
2018

Variations for Smoking As a Quantitative Trait Locus 3

ClinVar genetic disease variations for Smoking As a Quantitative Trait Locus 3:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CHRNA5 NM_000745.3(CHRNA5): c.1192G> A (p.Asp398Asn) single nucleotide variant risk factor rs16969968 GRCh37 Chromosome 15, 78882925: 78882925
2 CHRNA5 NM_000745.3(CHRNA5): c.1192G> A (p.Asp398Asn) single nucleotide variant risk factor rs16969968 GRCh38 Chromosome 15, 78590583: 78590583
3 CHRNA3 NM_001166694.1(CHRNA3): c.645C> T (p.Tyr215=) single nucleotide variant drug response rs1051730 GRCh37 Chromosome 15, 78894339: 78894339
4 CHRNA3 NM_001166694.1(CHRNA3): c.645C> T (p.Tyr215=) single nucleotide variant drug response rs1051730 GRCh38 Chromosome 15, 78601997: 78601997

Expression for Smoking As a Quantitative Trait Locus 3

Search GEO for disease gene expression data for Smoking As a Quantitative Trait Locus 3.

Pathways for Smoking As a Quantitative Trait Locus 3

GO Terms for Smoking As a Quantitative Trait Locus 3

Cellular components related to Smoking As a Quantitative Trait Locus 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.32 CHRNA3 CHRNA5
2 synapse GO:0045202 9.26 CHRNA3 CHRNA5
3 neuron projection GO:0043005 9.16 CHRNA3 CHRNA5
4 postsynaptic membrane GO:0045211 8.96 CHRNA3 CHRNA5
5 acetylcholine-gated channel complex GO:0005892 8.62 CHRNA3 CHRNA5

Biological processes related to Smoking As a Quantitative Trait Locus 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.48 CHRNA3 CHRNA5
2 ion transmembrane transport GO:0034220 9.46 CHRNA3 CHRNA5
3 chemical synaptic transmission GO:0007268 9.43 CHRNA3 CHRNA5
4 regulation of membrane potential GO:0042391 9.4 CHRNA3 CHRNA5
5 excitatory postsynaptic potential GO:0060079 9.37 CHRNA3 CHRNA5
6 nervous system process GO:0050877 9.32 CHRNA3 CHRNA5
7 response to nicotine GO:0035094 9.26 CHRNA3 CHRNA5
8 neuromuscular synaptic transmission GO:0007274 9.16 CHRNA3 CHRNA5
9 synaptic transmission, cholinergic GO:0007271 8.96 CHRNA3 CHRNA5
10 behavioral response to nicotine GO:0035095 8.62 CHRNA3 CHRNA5

Molecular functions related to Smoking As a Quantitative Trait Locus 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.37 CHRNA3 CHRNA5
2 extracellular ligand-gated ion channel activity GO:0005230 9.32 CHRNA3 CHRNA5
3 ligand-gated ion channel activity GO:0015276 9.26 CHRNA3 CHRNA5
4 acetylcholine binding GO:0042166 9.16 CHRNA3 CHRNA5
5 acetylcholine-gated cation-selective channel activity GO:0022848 8.96 CHRNA3 CHRNA5
6 acetylcholine receptor activity GO:0015464 8.62 CHRNA3 CHRNA5

Sources for Smoking As a Quantitative Trait Locus 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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