MCID: SMK004
MIFTS: 36

Smoking As a Quantitative Trait Locus 3

Categories: Genetic diseases, Respiratory diseases, Cancer diseases

Aliases & Classifications for Smoking As a Quantitative Trait Locus 3

MalaCards integrated aliases for Smoking As a Quantitative Trait Locus 3:

Name: Smoking As a Quantitative Trait Locus 3 57 29 6
Lung Cancer Susceptibility 2 57 13 6 73
Nicotine Dependence 57 73
Nicotine Dependence, Susceptibility to 57
Sqtl3 57

Classifications:



External Ids:

OMIM 57 612052
UMLS 73 C2677571

Summaries for Smoking As a Quantitative Trait Locus 3

MalaCards based summary : Smoking As a Quantitative Trait Locus 3, also known as lung cancer susceptibility 2, is related to tobacco addiction and substance dependence. An important gene associated with Smoking As a Quantitative Trait Locus 3 is CHRNA3 (Cholinergic Receptor Nicotinic Alpha 3 Subunit), and among its related pathways/superpathways are Transmission across Chemical Synapses and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. Affiliated tissues include lung, testes and brain, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Description from OMIM: 612052

Related Diseases for Smoking As a Quantitative Trait Locus 3

Graphical network of the top 20 diseases related to Smoking As a Quantitative Trait Locus 3:



Diseases related to Smoking As a Quantitative Trait Locus 3

Symptoms & Phenotypes for Smoking As a Quantitative Trait Locus 3

Clinical features from OMIM:

612052

GenomeRNAi Phenotypes related to Smoking As a Quantitative Trait Locus 3 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.28 CHRNA3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.28 CHRNA3
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.28 CHRNA5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.28 CHRNA5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.28 CHRNA3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.28 CHRNA5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.28 CHRNA3 CHRNA5
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.28 CHRNA5

Drugs & Therapeutics for Smoking As a Quantitative Trait Locus 3

Search Clinical Trials , NIH Clinical Center for Smoking As a Quantitative Trait Locus 3

Genetic Tests for Smoking As a Quantitative Trait Locus 3

Genetic tests related to Smoking As a Quantitative Trait Locus 3:

# Genetic test Affiliating Genes
1 Smoking As a Quantitative Trait Locus 3 29 CHRNA3 CHRNA5

Anatomical Context for Smoking As a Quantitative Trait Locus 3

MalaCards organs/tissues related to Smoking As a Quantitative Trait Locus 3:

41
Lung, Testes, Brain, Colon, Heart, Cortex, Amygdala

Publications for Smoking As a Quantitative Trait Locus 3

Articles related to Smoking As a Quantitative Trait Locus 3:

(show top 50) (show all 594)
# Title Authors Year
1
The lack of association between angiotensin-converting enzyme gene insertion/deletion polymorphism and nicotine dependence in multiple sclerosis. ( 28127518 )
2017
2
eNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia. ( 29050484 )
2017
3
Chronic low-grade peripheral inflammation is associated with severe nicotine dependence in schizophrenia: results from the national multicentric FACE-SZ cohort. ( 28238173 )
2017
4
Anxiety and Nicotine Dependence: Emerging Role of the Habenulo-Interpeduncular Axis. ( 27890353 )
2017
5
Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American. ( 28413702 )
2017
6
Association of ankyrin repeats &amp;amp; kinase domain containing 1 (<i>ANKK1</i>) gene polymorphism with co-morbid alcohol &amp;amp; nicotine dependence: A pilot study from a tertiary care treatment centre in north India. ( 28574012 )
2017
7
The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients. ( 28028641 )
2017
8
An association between the PPARI+-L162V polymorphism and nicotine dependency among patients with schizophrenia. ( 27624431 )
2016
9
Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland. ( 27127891 )
2016
10
Genetic Relationship between Schizophrenia and Nicotine Dependence. ( 27164557 )
2016
11
The association of dopamine pathway gene score, nicotine dependence and smoking cessation in a rural male population of Shandong, China. ( 27490263 )
2016
12
Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. ( 26239294 )
2016
13
Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research. ( 27327258 )
2016
14
Exploring the Severity of Dependence Scale (SDS) as a possible measure of nicotine dependence. ( 26566575 )
2016
15
Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence. ( 27634830 )
2016
16
A hierarchical instrumental decision theory of nicotine dependence. ( 25655891 )
2015
17
A functional polymorphism in the interleukin-1beta and severity of nicotine dependence in male schizophrenia: A case-control study. ( 25858413 )
2015
18
CYP2B6 gene single-nucleotide polymorphisms in an Italian population sample and relationship with nicotine dependence. ( 25489907 )
2015
19
Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. ( 25555482 )
2015
20
Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence. ( 26440539 )
2015
21
The role of mesoaccumbens dopamine in nicotine dependence. ( 25638334 )
2015
22
The possible role of maternal bonding style and CHRNB2 gene polymorphisms in nicotine dependence and related depressive phenotype. ( 25640319 )
2015
23
Nicotine dependence in an isolated population of Kashubians from North Poland: a population survey. ( 25652844 )
2015
24
Effect of variation in BDNF Val(66)Met polymorphism, smoking, and nicotine dependence on symptom severity of depressive and anxiety disorders. ( 25618300 )
2015
25
Association between genetic variants on chromosome 15q25 locus and several nicotine dependence traits in Polish population: a case-control study. ( 25632390 )
2015
26
The contribution of rare and common variants in 30 genes to risk nicotine dependence. ( 25450229 )
2015
27
Comparisons of three nicotine dependence scales in a multiethnic sample of young adult menthol and non-menthol smokers. ( 25744873 )
2015
28
Increased impulsivity in pathological gambling: Considering nicotine dependence. ( 25819174 )
2015
29
Elevated Risk of Nicotine Dependence Among Sib-pairs Discordant for Maternal Smoking During Pregnancy: Evidence from a 40-year Longitudinal Study. ( 25767988 )
2015
30
Correlation between nicotine dependence and barriers to cessation between exclusive cigarette smokers and dual (water pipe) smokers among Arab Americans. ( 25674035 )
2015
31
A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. ( 26220977 )
2015
32
Nicotine Dependence, Physical Activity, and Sedentary Behavior among Adult Smokers. ( 25839000 )
2015
33
Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. ( 26289589 )
2015
34
Relationships Between Craving Beliefs and Abstinence Self-Efficacy are Mediated by Smoking Motives and Moderated by Nicotine Dependence. ( 25744968 )
2015
35
T76. Baclofen as a Pharmacotherapy for the Treatment of Concurrent Alcohol and Nicotine Dependence: A Double-blind, Placebo-Controlled, Randomized Trial. ( 25868070 )
2015
36
Genetic risks to nicotine dependence predict negative mood and affect in current non-smokers. ( 25826680 )
2015
37
The effects of nicotine dependence and acute abstinence on the processing of drug and non-drug rewards. ( 25757672 )
2015
38
EFFECT OF CYP2A6*4 GENETIC POLYMORPHISMS ON SMOKING BEHAVIORS AND NICOTINE DEPENDENCE IN A GENERAL POPULATION OF JAPANESE MEN. ( 26370685 )
2015
39
An association between the use of hypnotics and quit status in the treatment of nicotine dependence with varenicline in bipolar disorder. ( 25627075 )
2015
40
Reasons for smoking cessation attempts among Japanese male smokers vary by nicotine dependence level: a cross-sectional study after the 2010 tobacco tax increase. ( 25795690 )
2015
41
Early emerging nicotine dependence symptoms in adolescence predict daily smoking in young adulthood. ( 25840749 )
2015
42
Role of the Neuregulin Signaling Pathway in Nicotine Dependence and Co-morbid Disorders. ( 26472527 )
2015
43
Ethnic-specific genetic association of variants in the corticotropin-releasing hormone receptor 1 gene with nicotine dependence. ( 25802844 )
2015
44
Determining the causes and consequences of nicotine dependence: emerging genetic research methods. ( 25135777 )
2014
45
Inhibitory control dysfunction in nicotine dependence and the influence of short-term abstinence. ( 25070928 )
2014
46
Nicotine dependence in the mental disorders, relationship with clinical indicators, and the meaning for the user. ( 25296154 )
2014
47
Psychiatric, psychosocial, and physical health correlates of co-occurring cannabis use disorders and nicotine dependence. ( 24183498 )
2014
48
Nicotine dependence and psychiatric and substance use disorder comorbidities among American Indians/Alaska Natives: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions. ( 25240520 )
2014
49
Association Between KCNJ6 (GIRK2) Gene Polymorphism rs2835859 and Post-operative Analgesia, Pain Sensitivity, and Nicotine Dependence. ( 25346042 )
2014
50
Genetic polymorphisms in glutathione-S-transferases are associated with anxiety and mood disorders in nicotine dependence. ( 24637631 )
2014

Variations for Smoking As a Quantitative Trait Locus 3

ClinVar genetic disease variations for Smoking As a Quantitative Trait Locus 3:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CHRNA5 NM_000745.3(CHRNA5): c.1192G> A (p.Asp398Asn) single nucleotide variant risk factor rs16969968 GRCh37 Chromosome 15, 78882925: 78882925
2 CHRNA5 NM_000745.3(CHRNA5): c.1192G> A (p.Asp398Asn) single nucleotide variant risk factor rs16969968 GRCh38 Chromosome 15, 78590583: 78590583
3 CHRNA3 NM_001166694.1(CHRNA3): c.645C> T (p.Tyr215=) single nucleotide variant drug response rs1051730 GRCh37 Chromosome 15, 78894339: 78894339
4 CHRNA3 NM_001166694.1(CHRNA3): c.645C> T (p.Tyr215=) single nucleotide variant drug response rs1051730 GRCh38 Chromosome 15, 78601997: 78601997

Expression for Smoking As a Quantitative Trait Locus 3

Search GEO for disease gene expression data for Smoking As a Quantitative Trait Locus 3.

Pathways for Smoking As a Quantitative Trait Locus 3

GO Terms for Smoking As a Quantitative Trait Locus 3

Cellular components related to Smoking As a Quantitative Trait Locus 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.32 CHRNA3 CHRNA5
2 synapse GO:0045202 9.26 CHRNA3 CHRNA5
3 neuron projection GO:0043005 9.16 CHRNA3 CHRNA5
4 postsynaptic membrane GO:0045211 8.96 CHRNA3 CHRNA5
5 acetylcholine-gated channel complex GO:0005892 8.62 CHRNA3 CHRNA5

Biological processes related to Smoking As a Quantitative Trait Locus 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.48 CHRNA3 CHRNA5
2 ion transmembrane transport GO:0034220 9.46 CHRNA3 CHRNA5
3 chemical synaptic transmission GO:0007268 9.43 CHRNA3 CHRNA5
4 regulation of membrane potential GO:0042391 9.4 CHRNA3 CHRNA5
5 excitatory postsynaptic potential GO:0060079 9.37 CHRNA3 CHRNA5
6 nervous system process GO:0050877 9.32 CHRNA3 CHRNA5
7 response to nicotine GO:0035094 9.26 CHRNA3 CHRNA5
8 neuromuscular synaptic transmission GO:0007274 9.16 CHRNA3 CHRNA5
9 synaptic transmission, cholinergic GO:0007271 8.96 CHRNA3 CHRNA5
10 behavioral response to nicotine GO:0035095 8.62 CHRNA3 CHRNA5

Molecular functions related to Smoking As a Quantitative Trait Locus 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.37 CHRNA3 CHRNA5
2 extracellular ligand-gated ion channel activity GO:0005230 9.32 CHRNA3 CHRNA5
3 ligand-gated ion channel activity GO:0015276 9.26 CHRNA3 CHRNA5
4 acetylcholine binding GO:0042166 9.16 CHRNA3 CHRNA5
5 acetylcholine-gated cation-selective channel activity GO:0022848 8.96 CHRNA3 CHRNA5
6 acetylcholine receptor activity GO:0015464 8.62 CHRNA3 CHRNA5

Sources for Smoking As a Quantitative Trait Locus 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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