MCID: SMT002
MIFTS: 38

Smooth Muscle Tumor

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Smooth Muscle Tumor

MalaCards integrated aliases for Smooth Muscle Tumor:

Name: Smooth Muscle Tumor 12 54 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4310
MeSH 44 D018235
NCIt 50 C3751
SNOMED-CT 67 75109009
UMLS 70 C0206658

Summaries for Smooth Muscle Tumor

MalaCards based summary : Smooth Muscle Tumor is related to mixed endometrial stromal and smooth muscle tumor and leiomyomatosis. An important gene associated with Smooth Muscle Tumor is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gastric cancer and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Fludarabine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and pancreas, and related phenotypes are cardiovascular system and cellular

Related Diseases for Smooth Muscle Tumor

Diseases related to Smooth Muscle Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 391)
# Related Disease Score Top Affiliating Genes
1 mixed endometrial stromal and smooth muscle tumor 32.6 MME CALD1
2 leiomyomatosis 31.8 PGR MED12 KIT ESR1
3 leiomyoma, uterine 31.0 PGR HMGA2 ESR1
4 rare tumor 30.8 KIT DES CR2 ACTC1
5 intravenous leiomyomatosis 30.7 PGR MME MED12 HMGA2 ESR1 DES
6 adenofibroma 30.3 VIM MME ACTC1
7 cystadenoma 30.3 SERPINA3 PGR MME
8 lymphangioleiomyomatosis 30.3 PGR IGF2 ESR1 DES
9 benign metastasizing leiomyoma 30.2 VIM PGR DES ACTC1
10 jejunal neoplasm 30.2 KIT CD34
11 leiomyoma 30.1 VIM S100A1 PGR MME MED12 KIT
12 embryonal sarcoma 30.1 VIM SERPINA3 KIT DES
13 leiomyosarcoma 30.0 VIM SERPINA3 S100A1 PGR MED12 KIT
14 endometrial stromal tumor 30.0 PGR MME ESR1 CALD1
15 cellular leiomyoma 30.0 MME MED12 DES CCL11 CALD1
16 retroperitoneal sarcoma 29.9 KIT CD34 CALD1
17 fasciitis 29.9 VIM ESR1 CD34 ACTC1
18 epithelioid leiomyosarcoma 29.9 VIM SERPINA3 PGR DES ACTC1
19 bizarre leiomyoma 29.9 PGR MED12 ESR1 CALD1 ACTC1
20 endometrial stromal sarcoma 29.9 VIM PGR MME KIT ESR1 DES
21 liver leiomyosarcoma 29.8 KIT CR2 CD34 CALD1
22 spindle cell sarcoma 29.7 VIM SERPINA3 KIT DES CD34 CALD1
23 mesenchymal cell neoplasm 29.7 SERPINA3 MME KIT HMGA2 CD34 CALD1
24 leukemia, acute lymphoblastic 29.5 MME KIT HMGA2 CDK2 CD34
25 angiomyolipoma 29.4 VIM S100A1 PGR MME KIT ESR1
26 adenosarcoma 29.4 VIM SERPINA3 PGR MME KIT ESR1
27 myoma 29.3 PGR MME MED12 KIT HMGA2 ESR1
28 neuroblastoma 28.7 TMSB15A NME1 KIT IGF2 ESR1 CDK2
29 rectum leiomyosarcoma 11.1
30 lymphangiectasis 10.4 VIM ACTC1
31 calcifying aponeurotic fibroma 10.4 PGR ACTC1
32 glassy cell carcinoma of the cervix 10.4 PGR ESR1
33 breast intraductal papillomatosis 10.4 PGR ESR1
34 testicular gonadoblastoma 10.4 VIM KIT
35 nipple carcinoma 10.4 PGR ESR1
36 bartholin's gland adenoma 10.4 PGR ESR1
37 acquired immunodeficiency syndrome 10.4
38 bartholin's gland adenoid cystic carcinoma 10.4 PGR ESR1
39 bartholin's gland benign neoplasm 10.4 PGR ESR1
40 chronic tympanitis 10.4 PGR ESR1
41 vestibular gland benign neoplasm 10.4 PGR ESR1
42 granulomatous endometritis 10.4 PGR ESR1
43 vulvar syringoma 10.4 PGR ESR1
44 cervical adenomyoma 10.4 PGR MME
45 cervical benign neoplasm 10.4 PGR MME
46 endometrial mucinous adenocarcinoma 10.4 VIM PGR
47 retroperitoneal fibrosis 10.4 VIM CCL11
48 glycogen-rich clear cell breast carcinoma 10.4 PGR ACTC1
49 fallopian tube endometriosis 10.4 PGR MME
50 adult type testicular granulosa cell tumor 10.4 PGR ESR1

Graphical network of the top 20 diseases related to Smooth Muscle Tumor:



Diseases related to Smooth Muscle Tumor

Symptoms & Phenotypes for Smooth Muscle Tumor

MGI Mouse Phenotypes related to Smooth Muscle Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10 ACTC1 CDK2 DES ESR1 IGF2 KIT
2 cellular MP:0005384 9.93 ACTC1 CD34 CDK2 DES ESR1 IGF2
3 integument MP:0010771 9.61 CD34 CDK2 ESR1 IGF2 KIT MME
4 muscle MP:0005369 9.28 ACTC1 CDK2 DES ESR1 IGF2 KIT

Drugs & Therapeutics for Smooth Muscle Tumor

Drugs for Smooth Muscle Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
2
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
3 Immunosuppressive Agents Phase 1
4 Antirheumatic Agents Phase 1
5 Immunologic Factors Phase 1
6 Alkylating Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ADMINISTRATION OF MOST CLOSELY MATCHED THIRD PARTY RAPIDLY GENERATED LMP, BARF1 and EBNA1 SPECIFIC CYTOTOXIC T-LYMPHOCYTES TO PATIENTS WITH EBV-POSITIVE LYMPHOMA AND OTHER EBV-POSITIVE MALIGNANCIES Recruiting NCT02287311 Phase 1 Cyclophosphamide;Fludarabine

Search NIH Clinical Center for Smooth Muscle Tumor

Cochrane evidence based reviews: smooth muscle tumor

Genetic Tests for Smooth Muscle Tumor

Anatomical Context for Smooth Muscle Tumor

MalaCards organs/tissues related to Smooth Muscle Tumor:

40
Smooth Muscle, Uterus, Pancreas, Prostate, Tongue, Bone Marrow, Spleen

Publications for Smooth Muscle Tumor

Articles related to Smooth Muscle Tumor:

(show top 50) (show all 558)
# Title Authors PMID Year
1
[Mesenchymal uterine tumors. Leiomyomas]. 54 61
19495761 2009
2
Colorectal mesenchymal tumors - from smooth muscle tumors to stromal tumors. 54 61
18949416 2008
3
Clinicopathological characteristics of gastrointestinal mesenchymal tumors and diagnostic value of endoscopic ultrasonography. 54 61
18505417 2008
4
Immunohistochemical analysis of p16, p53, and Ki-67 expression in uterine smooth muscle tumors. 61 54
18580309 2008
5
[Study of the mechanism of mast cell increase in cellular leiomyoma of uterus]. 61 54
17697600 2007
6
Expression of chemokines CCL5 and CCL11 by smooth muscle tumor cells of the uterus and its possible role in the recruitment of mast cells. 61 54
17368523 2007
7
Expression and prognostic role of molecular markers in 99 KIT-positive gastric stromal tumors in Taiwanese. 61 54
16489674 2006
8
[Gastrointestinal stromal tumor: a clinicopathological study of 74 cases]. 61 54
15796874 2005
9
Immunohistochemical analyses of gastric stromal tumors in Taiwanese. 61 54
14691596 2003
10
Expression of desmin and smooth muscle myosin heavy chain in dermatofibromas. 54 61
12296754 2002
11
MIB-1 (Ki-67), p53, estrogen receptor, and progesterone receptor expression in uterine smooth muscle tumors. 61 54
11567229 2001
12
Analysis of KIT mutation and protein expression in fine needle aspirates of gastrointestinal stromal/smooth muscle tumors. 54 61
11127756 2000
13
Spindle cell stromal tumors of gastrointestinal tract: a histological and immunohistochemical study. 54 61
1710946 1991
14
Insulin-like growth factor gene expression in human smooth muscle tumors. 54 61
2208134 1990
15
Diagnostic performance of preoperative MR imaging findings for differentiation of uterine leiomyoma with intraligamentous growth from subserosal leiomyoma. 61
33796904 2021
16
Molecular prognostication of uterine smooth muscle neoplasms: From CGH array to CINSARC signature and beyond. 61
33099852 2021
17
Chylous Ascites as a Presentation of Lymphangioleiomyomatosis. 61
33681402 2021
18
Non-hematopoietic neoplastic and pseudoneoplastic lesions of the spleen. 61
32600744 2021
19
Risk of incidental genital tract malignancies at the time of myomectomy and hysterectomy for benign conditions. 61
33321560 2021
20
Stanford parameters stratify the risk of recurrence in gynecologic smooth muscle tumors of uncertain malignant potential (STUMP). 61
33786917 2021
21
Trans-cervical trans-tracheal resection of cervical esophageal smooth muscle tumor. 61
33689739 2021
22
Role of surgery in treating epstein-barr virus-associated smooth muscle tumor (EBV-SMT) with central nervous system invasion: A systemic review from 1997 to 2019. 61
33576167 2021
23
Cutaneous Epstein-Barr virus-associated smooth muscle tumor in immunosuppression. 61
33245561 2021
24
Epstein-Barr virus-associated smooth muscle tumor in a kidney transplant recipient: A case-report and review of the literature. 61
32881184 2021
25
Clinicopathologic features and clinical outcomes of intravenous leiomyomatosis of the uterus: A case series. 61
33429819 2021
26
Fumarate hydratase-deficient renal cell carcinoma: A clinicopathological study of seven cases including hereditary and sporadic forms. 61
32977234 2020
27
Successful transoral videolaryngoscopic surgery for leiomyoma in the base of the tongue. 61
32057524 2020
28
Giant uterine mass with uterine smooth muscle tumor of uncertain malignant potential: A case report. 61
33204794 2020
29
Ovarian smooth muscle tumor of uncertain malignant potential (STUMP) associated with smooth muscle metaplasia of the endometriotic cyst. 61
32715612 2020
30
Leiomyosarcoma of the transverse colon with lymph node metastasis and malignant transformation: a case report. 61
33006746 2020
31
Intracranial Leiomyoma Associated with Epstein-Barr Virus: A Cerebellopontine Angle Mass Presenting with Trigeminal Neuralgia. 61
32450307 2020
32
Review of the Literature on Leiomyoma and Leiomyosarcoma of the Adrenal Gland: A Systematic Analysis of Case Reports. 61
32871746 2020
33
P16, Ki67, P53, and WT1 Expression in Uterine Smooth Muscle Tumors: An Adjunct in Confirming the Diagnosis of Malignancy in Ambiguous Cases. 61
32897968 2020
34
[Mutifocal EB virus associated smooth muscle tumor arising in intestinal tract of non transplantation/HIV patient: report of a case]. 61
32892563 2020
35
The successful management for long-term intractable enteroatmospheric fistula: A case report. 61
32817789 2020
36
Ultrasound Features of a Uterine Perivascular Epithelioid Cell Tumor (PEComa): Case Report and Literature Review. 61
32756336 2020
37
Ultrasound and clinical characteristics of uterine smooth muscle tumors of uncertain malignant potential (STUMPs). 61
32505056 2020
38
Uterineintravenous leiomyomatosis with cardiac involvement. 61
32636980 2020
39
Intraocular leiomyoma: Current concepts. 61
31923479 2020
40
Smooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases. 61
32051556 2020
41
Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing. 61
32299819 2020
42
Epstein-Barr virus associated hepatic smooth muscle tumor in a patient with acquired immunodeficiency syndrome: A case report. 61
32358363 2020
43
Intravascular Leiomyomatosis Extending to Right Atrium: A Rare Caused Syncope. 61
31743782 2020
44
Unexpected uterine smooth muscle tumor of uncertain malignant potential and sarcoma: A single center cohort study in South Korea. 61
32127150 2020
45
A Case Report of a Periurethral Smooth Muscle Tumor of Uncertain Malignant Potential. 61
32097190 2020
46
Clinical experience of uterine smooth muscle tumor of uncertain malignant potential in two gynecological centers: Oncological and obstetrical aspects. 61
31927240 2020
47
Epstein-Barr Virus-Associated Smooth Muscle Tumor of the Spine After Bone Marrow Transplant: Case Report and Review of Literature. 61
31809898 2020
48
[Benign metastasizing uterine leiomyoma with lung metastasis: problems of diagnosis and treatment]. 61
33030007 2020
49
Cutaneous Smooth Muscle Tumors: A Clinicopathological Study Focusing on the Under-Recognized Histological Features. 61
32343359 2020
50
Rare Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Patient with AIDS: A Case Report. 61
32224643 2020

Variations for Smooth Muscle Tumor

Expression for Smooth Muscle Tumor

Search GEO for disease gene expression data for Smooth Muscle Tumor.

Pathways for Smooth Muscle Tumor

GO Terms for Smooth Muscle Tumor

Biological processes related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.77 VIM KIT HMGA2 CD34 ACTC1
2 positive regulation of phospholipase C activity GO:0010863 9.4 KIT ESR1
3 intracellular steroid hormone receptor signaling pathway GO:0030518 9.32 PGR ESR1
4 paracrine signaling GO:0038001 9.26 PGR CD34
5 mast cell chemotaxis GO:0002551 9.16 KIT CCL11
6 muscle filament sliding GO:0030049 9.13 VIM DES ACTC1
7 stem cell differentiation GO:0048863 8.8 KIT HMGA2 ESR1

Molecular functions related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase binding GO:0051117 8.8 S100A1 PGR ESR1

Sources for Smooth Muscle Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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