MCID: SMT002
MIFTS: 38

Smooth Muscle Tumor

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Smooth Muscle Tumor

MalaCards integrated aliases for Smooth Muscle Tumor:

Name: Smooth Muscle Tumor 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4310
MeSH 44 D018235
NCIt 50 C3751
SNOMED-CT 68 189799007 75109009
UMLS 73 C0206658

Summaries for Smooth Muscle Tumor

MalaCards based summary : Smooth Muscle Tumor is related to intravenous leiomyomatosis and bizarre leiomyoma. An important gene associated with Smooth Muscle Tumor is PGR (Progesterone Receptor), and among its related pathways/superpathways is Striated Muscle Contraction. The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and lung, and related phenotypes are cellular and hematopoietic system

Related Diseases for Smooth Muscle Tumor

Diseases related to Smooth Muscle Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 intravenous leiomyomatosis 31.8 DES ESR1
2 bizarre leiomyoma 30.7 ACTC1 PGR
3 leiomyosarcoma 30.7 ACTC1 DES KIT PGR VIM
4 fasciitis 29.6 ACTC1 DES VIM
5 lymphangioleiomyomatosis 28.8 DES ESR1 PGR
6 gastrointestinal stromal tumor 28.8 ACTC1 DES KIT VIM
7 leiomyoma 28.3 ACTC1 DES ESR1 HMGA2 KIT PGR
8 perivascular epithelioid cell tumor 28.3 ACTC1 DES KIT PGR VIM
9 adenosarcoma 28.0 DES ESR1 KIT PGR
10 endometrial stromal sarcoma 27.5 ACTC1 DES ESR1 KIT PGR VIM
11 mixed endometrial stromal and smooth muscle tumor 12.4
12 leiomyoma, uterine 11.3
13 leiomyomatosis 11.2
14 rectum leiomyosarcoma 10.9
15 calcifying aponeurotic fibroma 10.8 ACTC1 PGR
16 myxoid leiomyosarcoma 10.8 ACTC1 PGR
17 lymphangiectasis 10.7 ACTC1 VIM
18 intravascular papillary endothelial hyperplasia 10.7 ACTC1 VIM
19 adenofibroma 10.7 ACTC1 VIM
20 retroperitoneal fibrosis 10.7 CCL11 VIM
21 angiocentric glioma 10.7 ACTC1 VIM
22 chickenpox 10.7 ACTC1 PGR
23 breast angiosarcoma 10.6 KIT PGR
24 uterine body mixed cancer 10.6 KIT PGR
25 papillary hidradenoma 10.6 KIT PGR
26 mast-cell sarcoma 10.6 KIT VIM
27 granulosa cell tumor of the ovary 10.5 ACTC1 VIM
28 kimura disease 10.5 CCL11 CCR3
29 senile angioma 10.5 KIT VIM
30 chondroma 10.5 ACTC1 HMGA2
31 dysgerminoma of ovary 10.5 KIT PGR
32 necrotizing sialometaplasia 10.5 ACTC1 KIT
33 perineurioma 10.4 KIT VIM
34 fibroblastic rheumatism 10.4 ACTC1 DES
35 cutaneous leiomyosarcoma 10.4 ACTC1 DES
36 botryoid rhabdomyosarcoma 10.4 ACTC1 DES
37 papillary adenocarcinoma 10.4 PGR VIM
38 pleomorphic lipoma 10.4 HMGA2 PGR
39 infantile digital fibromatosis 10.4 DES VIM
40 primitive neuroectodermal tumor of the cervix uteri 10.4 DES VIM
41 ischemic fasciitis 10.4 ACTC1 DES
42 biphasic synovial sarcoma 10.3 DES VIM
43 angiomyoma 10.3 HMGA2 KIT
44 spindle cell liposarcoma 10.3 CR2 KIT
45 juvenile xanthogranuloma 10.3 DES VIM
46 non-langerhans-cell histiocytosis 10.3 ACTC1 DES
47 desmoplastic small round cell tumor 10.3 DES VIM
48 mesenchymal chondrosarcoma 10.3 DES VIM
49 extraskeletal ewing sarcoma 10.3 DES VIM
50 gallbladder sarcoma 10.3 DES KIT

Graphical network of the top 20 diseases related to Smooth Muscle Tumor:



Diseases related to Smooth Muscle Tumor

Symptoms & Phenotypes for Smooth Muscle Tumor

MGI Mouse Phenotypes related to Smooth Muscle Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 DES ESR1 KIT ACTC1 PGR CCR3
2 hematopoietic system MP:0005397 9.87 ESR1 KIT PGR CCL11 CCR3 VIM
3 homeostasis/metabolism MP:0005376 9.86 DES ESR1 KIT ACTC1 PGR CCR3
4 immune system MP:0005387 9.7 ESR1 KIT PGR CCL11 CCR3 VIM
5 muscle MP:0005369 9.43 ESR1 KIT ACTC1 PGR VIM DES
6 respiratory system MP:0005388 9.02 ESR1 KIT CCL11 CCR3 VIM

Drugs & Therapeutics for Smooth Muscle Tumor

Drugs for Smooth Muscle Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 2 51-84-3 187
2 abobotulinumtoxinA Phase 2
3 Cholinergic Agents Phase 2
4 Neuromuscular Agents Phase 2
5 Neurotransmitter Agents Phase 2
6 onabotulinumtoxinA Phase 2
7 Peripheral Nervous System Agents Phase 2
8 Botulinum Toxins, Type A Phase 2
9 Botulinum Toxins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum Toxin Completed NCT00971620 Phase 2
2 Surgery for Intravenous Leiomyomatosis Completed NCT01707862
3 The Role of Fibroblast Activation in Uterine Fibroid Not yet recruiting NCT03444987

Search NIH Clinical Center for Smooth Muscle Tumor

Cochrane evidence based reviews: smooth muscle tumor

Genetic Tests for Smooth Muscle Tumor

Anatomical Context for Smooth Muscle Tumor

MalaCards organs/tissues related to Smooth Muscle Tumor:

41
Smooth Muscle, Uterus, Lung, Liver, Heart, Endothelial, Tonsil

Publications for Smooth Muscle Tumor

Articles related to Smooth Muscle Tumor:

(show top 50) (show all 187)
# Title Authors Year
1
Review of the literature laparoscopic surgery for metastatic hepatic leiomyosarcoma associated with smooth muscle tumor of uncertain malignant potential: Case report. ( 29713398 )
2018
2
A clinicopathologic review and obstetric outcome of uterine smooth muscle tumor of uncertain malignant potential (STUMP) in a single institution. ( 29902779 )
2018
3
Epstein-Barr virus-associated smooth muscle tumor involving the spine of an HIV-infected patient: Case report and review of the literature. ( 29605279 )
2018
4
Uterine Smooth Muscle Tumor of Uncertain Malignant Potential: Clinicopathologic-Sonographic Characteristics, Follow-Up and Recurrence. ( 29147439 )
2017
5
Resolution of Multifocal Epstein-Barr Virus-Related Smooth Muscle Tumor in a Patient with GATA2 Deficiency Following Hematopoietic Stem Cell Transplantation. ( 27924436 )
2017
6
Potential role of BCL2 in the recurrence of uterine smooth muscle tumors of uncertain malignant potential. ( 28004108 )
2017
7
EBV-associated hepatic smooth muscle tumor of uncertain biologic behavior after heart transplantation in a pediatric patient: case report. ( 28280632 )
2017
8
Primary inferior vena cava smooth muscle tumor with diffuse bizarre giant nuclei and low mitotic rate: a nomenclatural conundrum. ( 28623706 )
2017
9
Concomitant Epstein-Barr Virus-associated smooth muscle tumor and granulomatous inflammation of the liver. ( 28756985 )
2017
10
PET/CT in an 8-Year-Old Girl With Epstein-Barr Virus-Associated Smooth Muscle Tumor. ( 28806251 )
2017
11
Proposed novel nomenclature of vulvar smooth muscle tumors; a case of Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP) of the vulva. ( 28180147 )
2017
12
Ellipsoid Smooth Muscle Tumor of the Lower Eyelid: An Exploration of Its Possible Origin. ( 28700399 )
2017
13
Mixed endometrial stromal and smooth muscle tumor of the uterus in a postmenopausal woman: morphologic and immunohistochemical features. ( 29953805 )
2017
14
Epstein-Barr virus-associated smooth muscle tumor as the initial presentation of HIV infection: A case report. ( 28532583 )
2017
15
Is differential expression of p16INK4a based on the classification of uterine smooth muscle tumors associated with a different prognosis? A meta-analysis. ( 28340268 )
2017
16
Morcellator's Port-site Metastasis of a Uterine Smooth Muscle Tumor of Uncertain Malignant Potential After Minimally Invasive Myomectomy. ( 26851127 )
2016
17
Lacrimal Sac Smooth Muscle Tumor of Uncertain Malignant Potential. ( 27306954 )
2016
18
Epstein-Barr virus-associated smooth muscle tumor of the cavernous sinus: a delayed complication of allogenic peripheral blood stem cell transplantation: case report. ( 27341041 )
2016
19
Smooth Muscle Tumor Originating in the Pleura: A Case Report and Updated Literature Review. ( 27747117 )
2016
20
Dome-shaped metastatic lesion on the scalp from a uterine smooth muscle tumor of uncertain malignant potential (STUMP). ( 27086706 )
2016
21
A clinicopathological study of atypical leiomyomas: Benign variant leiomyoma or smooth-muscle tumor of uncertain malignant potential. ( 26893755 )
2016
22
The role of fibroblast growth factor 2 in patients with uterine smooth muscle tumors: an immunohistochemical study. ( 27825029 )
2016
23
Epstein-Barr virus-associated iris smooth muscle tumor with epithelioid morphology in AIDS patients: a case report. ( 27099533 )
2016
24
EMMPRIN (CD147) Expression in Smooth Muscle Tumors of the Uterus. ( 26352545 )
2016
25
Successful pregnancy following myomectomy for uterine smooth muscle tumor of uncertain malignant potential: A case report and review of the literature. ( 26937476 )
2016
26
Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors. ( 26892441 )
2016
27
Epstein-Barr Virus-Associated Smooth Muscle Tumor. ( 27362573 )
2016
28
Rare Presentations of Epstein-Barr Virus--Associated Smooth Muscle Tumor in Children. ( 26230054 )
2016
29
Primary Intraosseous Smooth Muscle Tumor of Uncertain Malignant Potential: Original Report and Molecular Characterization. ( 27994831 )
2016
30
Comparison of the diagnostic accuracy of contrast-enhanced MRI and diffusion-weighted MRI in the differentiation between uterine leiomyosarcoma / smooth muscle tumor with uncertain malignant potential and benign leiomyoma. ( 26383110 )
2015
31
High 18F-FDG uptake for uterine smooth muscle tumor of uncertain malignant potential. ( 25674868 )
2015
32
Mixed endometrial stromal and smooth muscle tumor with heart metastasis: report of a case and review of literature. ( 25755804 )
2015
33
Two-stage resection of a disseminated mixed endometrial stromal sarcoma and smooth muscle tumor with intravascular and intracardiac extension. ( 26701002 )
2015
34
Bizarre leiomyoma of uterus/smooth muscle tumor of uncertain malignant potential: A diagnostic dilemma. ( 26960523 )
2015
35
Expression of B23/Nucleophosphamine Nonribosomal Nucleolar Protein in Smooth Muscle Tumors of the Corpus Uteri. ( 26642792 )
2015
36
Epstein-Barr Virus-Associated Pulmonary Smooth Muscle Tumor After Lung Transplantation. ( 26046906 )
2015
37
Biomarker resolution of uterine smooth muscle tumor necrosis as benign vs malignant. ( 25698060 )
2015
38
Uterine smooth muscle tumor analysis by comparative genomic hybridization: a useful diagnostic tool in challenging lesions. ( 25932961 )
2015
39
Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors. ( 26472283 )
2015
40
Effects of Morcellation of Uterine Smooth Muscle Tumor of Uncertain Malignant Potential and Endometrial Stromal Sarcoma: Case Series and Recommendations for Clinical Practice. ( 25596464 )
2015
41
An immunohistochemical analysis of stathmin 1 expression in uterine smooth muscle tumors: differential expression in leiomyosarcomas and leiomyomas. ( 26045786 )
2015
42
MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors. ( 24196187 )
2014
43
Uterine smooth muscle tumors with features suggesting fumarate hydratase aberration: detailed morphologic analysis and correlation with S-(2-succino)-cysteine immunohistochemistry. ( 24309325 )
2014
44
MA1llerian Adenosarcoma of the Uterus With Low-grade Sarcomatous Overgrowth Characterized by Prominent Hydropic Change Resulting in Mimicry of a Smooth Muscle Tumor. ( 25272296 )
2014
45
The measurement of stiffness of uterine smooth muscle tumor by elastography. ( 25019043 )
2014
46
CD147 expression in uterine smooth muscle tumors, and its potential role as a diagnostic and prognostic marker in patients with leiomyosarcoma. ( 25509988 )
2014
47
Atypical smooth muscle tumor of the vagina--a pediatric case report and review of the literature. ( 23701791 )
2013
48
Multifocal Histologically Malignant Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Pediatric Transplant Patient With an Indolent Course. ( 23842005 )
2013
49
Primary mesenteric smooth muscle tumor: an entity with unpredictable biologic behavior. ( 24062958 )
2013
50
Completely infarcted smooth muscle tumor of the placental membrane. ( 23279350 )
2013

Variations for Smooth Muscle Tumor

Expression for Smooth Muscle Tumor

Search GEO for disease gene expression data for Smooth Muscle Tumor.

Pathways for Smooth Muscle Tumor

Pathways related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 ACTC1 DES VIM

GO Terms for Smooth Muscle Tumor

Biological processes related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.8 CCL11 CCR3 CR2 ESR1 HMGA2 KIT
2 positive regulation of gene expression GO:0010628 9.71 ACTC1 HMGA2 KIT VIM
3 positive regulation of angiogenesis GO:0045766 9.63 CCL11 CCR3 HMGA2
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.54 ESR1 HMGA2 KIT
5 response to radiation GO:0009314 9.48 CCL11 KIT
6 intermediate filament organization GO:0045109 9.43 DES VIM
7 positive regulation of phospholipase C activity GO:0010863 9.32 ESR1 KIT
8 mast cell chemotaxis GO:0002551 9.16 CCL11 KIT
9 muscle filament sliding GO:0030049 9.13 ACTC1 DES VIM
10 stem cell differentiation GO:0048863 8.8 ESR1 HMGA2 KIT

Molecular functions related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Smooth Muscle Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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