MCID: SMT002
MIFTS: 35

Smooth Muscle Tumor

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Smooth Muscle Tumor

MalaCards integrated aliases for Smooth Muscle Tumor:

Name: Smooth Muscle Tumor 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4310
MeSH 44 D018235
NCIt 50 C3751
SNOMED-CT 68 75109009
UMLS 73 C0206658

Summaries for Smooth Muscle Tumor

MalaCards based summary : Smooth Muscle Tumor is related to intravenous leiomyomatosis and leiomyomatosis. An important gene associated with Smooth Muscle Tumor is PGR (Progesterone Receptor), and among its related pathways/superpathways are Striated Muscle Contraction and G-protein signaling_Rap2B regulation pathway. The drugs Acetylcholine and Botulinum Toxins, Type A have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and lung, and related phenotypes are cellular and hematopoietic system

Related Diseases for Smooth Muscle Tumor

Diseases related to Smooth Muscle Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 intravenous leiomyomatosis 32.3 DES ESR1
2 leiomyomatosis 32.3 ESR1 PGR
3 leiomyoma, uterine 32.0 ESR1 HMGA2 PGR
4 leiomyosarcoma 31.6 ACTC1 DES KIT PGR VIM
5 leiomyoma 30.9 ACTC1 DES ESR1 HMGA2 KIT PGR
6 bizarre leiomyoma 29.8 ACTC1 PGR
7 lymphangioleiomyomatosis 29.6 DES ESR1 PGR
8 fasciitis 29.5 ACTC1 DES VIM
9 endometrial stromal sarcoma 29.5 ACTC1 DES ESR1 KIT PGR VIM
10 adenosarcoma 29.4 DES ESR1 KIT PGR
11 perivascular epithelioid cell tumor 29.1 ACTC1 DES KIT PGR VIM
12 mixed endometrial stromal and smooth muscle tumor 12.5
13 immunodeficiency 58 11.0
14 rectum leiomyosarcoma 11.0
15 sarcoma 10.3
16 clear cell meningioma 10.2 PGR VIM
17 retroperitoneal fibrosis 10.2 CCL11 VIM
18 sertoli cell tumor 10.2 PGR VIM
19 mast-cell sarcoma 10.2 KIT VIM
20 pleomorphic lipoma 10.2 HMGA2 PGR
21 senile angioma 10.2 KIT VIM
22 papillary hidradenoma 10.2 KIT PGR
23 angiomyoma 10.2 HMGA2 KIT
24 amelanotic melanoma 10.2 KIT VIM
25 infantile digital fibromatosis 10.2 DES VIM
26 primitive neuroectodermal tumor of the cervix uteri 10.2 DES VIM
27 kimura disease 10.2 CCL11 CCR3
28 perineurioma 10.2 KIT VIM
29 syringocystadenoma papilliferum 10.2 DES VIM
30 biphasic synovial sarcoma 10.2 DES VIM
31 mixed cell type cancer 10.1 KIT PGR
32 vestibular gland benign neoplasm 10.1 ESR1 PGR
33 bartholin's gland adenoma 10.1 ESR1 PGR
34 juvenile xanthogranuloma 10.1 DES VIM
35 vulvar syringoma 10.1 ESR1 PGR
36 glassy cell carcinoma of the cervix 10.1 ESR1 PGR
37 lung leiomyoma 10.1 ESR1 PGR
38 pleomorphic liposarcoma 10.1 DES VIM
39 vulvar benign neoplasm 10.1 ESR1 PGR
40 trigonitis 10.1 ESR1 PGR
41 vulvar leiomyoma 10.1 ESR1 PGR
42 desmoplastic small round cell tumor 10.1 DES VIM
43 predominantly cortical thymoma 10.1 ESR1 PGR
44 papillary adenocarcinoma 10.1 PGR VIM
45 breast medullary carcinoma 10.1 ESR1 PGR
46 breast scirrhous carcinoma 10.1 ESR1 PGR
47 bartholin's gland benign neoplasm 10.1 ESR1 PGR
48 gallbladder sarcoma 10.1 DES KIT
49 oncocytic breast carcinoma 10.1 ESR1 PGR
50 mesenchymal chondrosarcoma 10.1 DES VIM

Graphical network of the top 20 diseases related to Smooth Muscle Tumor:



Diseases related to Smooth Muscle Tumor

Symptoms & Phenotypes for Smooth Muscle Tumor

MGI Mouse Phenotypes related to Smooth Muscle Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 ACTC1 CCR3 DES ESR1 KIT PGR
2 hematopoietic system MP:0005397 9.87 CCL11 CCR3 CR2 ESR1 KIT PGR
3 homeostasis/metabolism MP:0005376 9.86 ACTC1 CCR3 CR2 DES ESR1 KIT
4 immune system MP:0005387 9.7 CCL11 CCR3 CR2 ESR1 KIT PGR
5 muscle MP:0005369 9.43 ACTC1 DES ESR1 KIT PGR VIM
6 respiratory system MP:0005388 9.02 CCL11 CCR3 ESR1 KIT VIM

Drugs & Therapeutics for Smooth Muscle Tumor

Drugs for Smooth Muscle Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 2 51-84-3 187
2 Botulinum Toxins, Type A Phase 2
3 Neurotransmitter Agents Phase 2
4 Cholinergic Agents Phase 2
5 abobotulinumtoxinA Phase 2
6 Neuromuscular Agents Phase 2
7 Peripheral Nervous System Agents Phase 2
8 Acetylcholine Release Inhibitors Phase 2
9 onabotulinumtoxinA Phase 2
10 Botulinum Toxins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum Toxin Completed NCT00971620 Phase 2
2 Surgery for Intravenous Leiomyomatosis Completed NCT01707862
3 The Role of Fibroblast Activation in Uterine Fibroid Not yet recruiting NCT03444987

Search NIH Clinical Center for Smooth Muscle Tumor

Cochrane evidence based reviews: smooth muscle tumor

Genetic Tests for Smooth Muscle Tumor

Anatomical Context for Smooth Muscle Tumor

MalaCards organs/tissues related to Smooth Muscle Tumor:

41
Smooth Muscle, Uterus, Lung, Ovary, Prostate, Liver, Cervix

Publications for Smooth Muscle Tumor

Articles related to Smooth Muscle Tumor:

(show top 50) (show all 117)
# Title Authors Year
1
Review of the literature laparoscopic surgery for metastatic hepatic leiomyosarcoma associated with smooth muscle tumor of uncertain malignant potential: Case report. ( 29713398 )
2018
2
A clinicopathologic review and obstetric outcome of uterine smooth muscle tumor of uncertain malignant potential (STUMP) in a single institution. ( 29902779 )
2018
3
Epstein-Barr virus-associated smooth muscle tumor involving the spine of an HIV-infected patient: Case report and review of the literature. ( 29605279 )
2018
4
Laryngeal Epstein-Barr Virus-Associated Smooth Muscle Tumor in an Undernourished Child. ( 30120720 )
2018
5
Uterine Smooth Muscle Tumor of Uncertain Malignant Potential: Clinicopathologic-Sonographic Characteristics, Follow-Up and Recurrence. ( 29147439 )
2017
6
Resolution of Multifocal Epstein-Barr Virus-Related Smooth Muscle Tumor in a Patient with GATA2 Deficiency Following Hematopoietic Stem Cell Transplantation. ( 27924436 )
2017
7
EBV-associated hepatic smooth muscle tumor of uncertain biologic behavior after heart transplantation in a pediatric patient: case report. ( 28280632 )
2017
8
Primary inferior vena cava smooth muscle tumor with diffuse bizarre giant nuclei and low mitotic rate: a nomenclatural conundrum. ( 28623706 )
2017
9
Concomitant Epstein-Barr Virus-associated smooth muscle tumor and granulomatous inflammation of the liver. ( 28756985 )
2017
10
PET/CT in an 8-Year-Old Girl With Epstein-Barr Virus-Associated Smooth Muscle Tumor. ( 28806251 )
2017
11
Proposed novel nomenclature of vulvar smooth muscle tumors; a case of Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP) of the vulva. ( 28180147 )
2017
12
Ellipsoid Smooth Muscle Tumor of the Lower Eyelid: An Exploration of Its Possible Origin. ( 28700399 )
2017
13
Mixed endometrial stromal and smooth muscle tumor of the uterus in a postmenopausal woman: morphologic and immunohistochemical features. ( 29953805 )
2017
14
Epstein-Barr virus-associated smooth muscle tumor as the initial presentation of HIV infection: A case report. ( 28532583 )
2017
15
Morcellator's Port-site Metastasis of a Uterine Smooth Muscle Tumor of Uncertain Malignant Potential After Minimally Invasive Myomectomy. ( 26851127 )
2016
16
Lacrimal Sac Smooth Muscle Tumor of Uncertain Malignant Potential. ( 27306954 )
2016
17
Epstein-Barr virus-associated smooth muscle tumor of the cavernous sinus: a delayed complication of allogenic peripheral blood stem cell transplantation: case report. ( 27341041 )
2016
18
Smooth Muscle Tumor Originating in the Pleura: A Case Report and Updated Literature Review. ( 27747117 )
2016
19
Dome-shaped metastatic lesion on the scalp from a uterine smooth muscle tumor of uncertain malignant potential (STUMP). ( 27086706 )
2016
20
A clinicopathological study of atypical leiomyomas: Benign variant leiomyoma or smooth-muscle tumor of uncertain malignant potential. ( 26893755 )
2016
21
Epstein-Barr virus-associated iris smooth muscle tumor with epithelioid morphology in AIDS patients: a case report. ( 27099533 )
2016
22
Successful pregnancy following myomectomy for uterine smooth muscle tumor of uncertain malignant potential: A case report and review of the literature. ( 26937476 )
2016
23
Epstein-Barr Virus-Associated Smooth Muscle Tumor. ( 27362573 )
2016
24
Rare Presentations of Epstein-Barr Virus--Associated Smooth Muscle Tumor in Children. ( 26230054 )
2016
25
Primary Intraosseous Smooth Muscle Tumor of Uncertain Malignant Potential: Original Report and Molecular Characterization. ( 27994831 )
2016
26
Comparison of the diagnostic accuracy of contrast-enhanced MRI and diffusion-weighted MRI in the differentiation between uterine leiomyosarcoma / smooth muscle tumor with uncertain malignant potential and benign leiomyoma. ( 26383110 )
2015
27
High 18F-FDG uptake for uterine smooth muscle tumor of uncertain malignant potential. ( 25674868 )
2015
28
Mixed endometrial stromal and smooth muscle tumor with heart metastasis: report of a case and review of literature. ( 25755804 )
2015
29
Two-stage resection of a disseminated mixed endometrial stromal sarcoma and smooth muscle tumor with intravascular and intracardiac extension. ( 26701002 )
2015
30
Bizarre leiomyoma of uterus/smooth muscle tumor of uncertain malignant potential: A diagnostic dilemma. ( 26960523 )
2015
31
Epstein-Barr Virus-Associated Pulmonary Smooth Muscle Tumor After Lung Transplantation. ( 26046906 )
2015
32
Biomarker resolution of uterine smooth muscle tumor necrosis as benign vs malignant. ( 25698060 )
2015
33
Uterine smooth muscle tumor analysis by comparative genomic hybridization: a useful diagnostic tool in challenging lesions. ( 25932961 )
2015
34
Effects of Morcellation of Uterine Smooth Muscle Tumor of Uncertain Malignant Potential and Endometrial Stromal Sarcoma: Case Series and Recommendations for Clinical Practice. ( 25596464 )
2015
35
MA1llerian Adenosarcoma of the Uterus With Low-grade Sarcomatous Overgrowth Characterized by Prominent Hydropic Change Resulting in Mimicry of a Smooth Muscle Tumor. ( 25272296 )
2014
36
The measurement of stiffness of uterine smooth muscle tumor by elastography. ( 25019043 )
2014
37
Atypical smooth muscle tumor of the vagina--a pediatric case report and review of the literature. ( 23701791 )
2013
38
Multifocal Histologically Malignant Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Pediatric Transplant Patient With an Indolent Course. ( 23842005 )
2013
39
Primary mesenteric smooth muscle tumor: an entity with unpredictable biologic behavior. ( 24062958 )
2013
40
Completely infarcted smooth muscle tumor of the placental membrane. ( 23279350 )
2013
41
Epstein-Barr virus-associated smooth muscle tumor-report of 3 tumors including 1 intracerebral case with a prominent intratumoral B-lymphocytic component and plasma cells. ( 23022018 )
2013
42
Smooth muscle tumor of uncertain malignant potential of the urinary bladder: a case report and review of the literature. ( 23810438 )
2013
43
Extrauterine mixed endometrial stromal-smooth muscle tumor: Report of an unusual entity. ( 24455616 )
2013
44
Mixed endometrial stromal and smooth muscle tumor: report of a case with focal anaplasia and early postoperative lung metastasis. ( 23692422 )
2013
45
Epstein-Barr Virus associated primary intracranial smooth muscle tumor in HIV positive patient: case report and review of the literature. ( 24319862 )
2013
46
Periurethral smooth muscle tumor of undetermined malignant potential. ( 22720177 )
2012
47
Myxoid mixed low-grade endometrial stromal sarcoma and smooth muscle tumor of the uterus. Case report. ( 22716064 )
2012
48
Uterine smooth muscle tumor of uncertain malignant potential: A rare cause of multiple pulmonary nodules. ( 23248426 )
2012
49
Epstein-Barr virus-associated smooth muscle tumor of the tonsil. ( 21885224 )
2012
50
Epstein-Barr virus--associated smooth muscle tumor mimicking cutaneous angioleiomyoma. ( 21285860 )
2011

Variations for Smooth Muscle Tumor

Expression for Smooth Muscle Tumor

Search GEO for disease gene expression data for Smooth Muscle Tumor.

Pathways for Smooth Muscle Tumor

Pathways related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 ACTC1 DES VIM
2 10.16 CCL11 DES KIT VIM

GO Terms for Smooth Muscle Tumor

Biological processes related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.62 ACTC1 HMGA2 KIT VIM
2 positive regulation of angiogenesis GO:0045766 9.58 CCL11 CCR3 HMGA2
3 response to radiation GO:0009314 9.43 CCL11 KIT
4 intermediate filament organization GO:0045109 9.37 DES VIM
5 positive regulation of phospholipase C activity GO:0010863 9.26 ESR1 KIT
6 mast cell chemotaxis GO:0002551 9.16 CCL11 KIT
7 muscle filament sliding GO:0030049 9.13 ACTC1 DES VIM
8 stem cell differentiation GO:0048863 8.8 ESR1 HMGA2 KIT

Molecular functions related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Smooth Muscle Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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