MCID: SMT002
MIFTS: 37

Smooth Muscle Tumor

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Smooth Muscle Tumor

MalaCards integrated aliases for Smooth Muscle Tumor:

Name: Smooth Muscle Tumor 12 54 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4310
MeSH 43 D018235
NCIt 49 C3751
SNOMED-CT 67 75109009
UMLS 71 C0206658

Summaries for Smooth Muscle Tumor

MalaCards based summary : Smooth Muscle Tumor is related to mixed endometrial stromal and smooth muscle tumor and leiomyomatosis. An important gene associated with Smooth Muscle Tumor is PGR (Progesterone Receptor), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include smooth muscle, breast and uterus, and related phenotypes are cellular and cardiovascular system

Related Diseases for Smooth Muscle Tumor

Diseases related to Smooth Muscle Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 444)
# Related Disease Score Top Affiliating Genes
1 mixed endometrial stromal and smooth muscle tumor 34.6 MME CALD1
2 leiomyomatosis 32.5 PGR MED12 KIT ESR1
3 intravenous leiomyomatosis 32.4 PGR MME ESR1 DES CALD1
4 leiomyoma, uterine 31.0 TMSB15A PGR MED12 IGF2 HMGA2 ESR1
5 endometrial stromal tumor 30.8 PGR MME CALD1
6 diffuse peritoneal leiomyomatosis 30.7 PGR MED12
7 benign metastasizing leiomyoma 30.6 VIM PGR DES BCL2 ACTC1
8 rare tumor 30.6 KIT DES CR2 ACTC1
9 leiomyosarcoma 30.5 VIM SERPINA3 S100A1 PGR MED12 KIT
10 adenomyosis 30.5 PGR MME ESR1
11 lymphangioleiomyomatosis 30.3 PGR IGF2 ESR1 DES
12 adenofibroma 30.3 VIM MME ACTC1
13 embryonal sarcoma 30.3 VIM SERPINA3 KIT DES
14 endometrial adenocarcinoma 30.3 VIM PGR ESR1
15 cellular leiomyoma 30.3 MME MED12 DES CCL11 CALD1
16 gastric leiomyoma 30.3 KIT CALD1
17 malignant fibrous histiocytoma of bone 30.2 DES CALD1
18 bizarre leiomyoma 30.2 PGR MED12 ESR1 CALD1 ACTC1
19 epithelioid leiomyosarcoma 30.0 VIM SERPINA3 DES CALD1 ACTC1
20 cystadenoma 30.0 SERPINA3 PGR MME KIT
21 angiomyoma 30.0 CD34 CALD1
22 giant cell tumor 29.9 VIM SERPINA3 DES ACTC1
23 jejunal neoplasm 29.8 KIT CD34
24 endometrial stromal sarcoma 29.7 VIM PGR MME KIT ESR1 DES
25 leiomyoma 29.6 VIM S100A1 PGR MME MED12 KIT
26 rhabdomyosarcoma 29.6 VIM KIT IGF2 DES ACTC1
27 liposarcoma 29.6 VIM HMGA2 DES CD34
28 mesenchymal cell neoplasm 29.5 SERPINA3 MME KIT HMGA2 CD34 CALD1
29 spindle cell sarcoma 29.5 VIM SERPINA3 DES CD34 ACTC1
30 renal cell carcinoma, nonpapillary 29.5 VIM S100A1 NME1 MME KIT ACTC1
31 retroperitoneal leiomyosarcoma 29.5 KIT CD34 CALD1
32 retroperitoneal sarcoma 29.5 KIT CD34 CALD1
33 adenomyoma 29.4 PGR MME MED12 ESR1 CALD1
34 pleomorphic lipoma 29.4 SERPINA3 PGR HMGA2 CD34
35 histiocytoma 29.3 VIM SERPINA3 KIT CD34 ACTC1
36 fibrous histiocytoma 29.3 VIM SERPINA3 DES CD34 ACTC1
37 angiomyolipoma 29.2 VIM S100A1 PGR MME KIT ESR1
38 liver leiomyosarcoma 29.2 KIT CR2 CD34 CALD1
39 perivascular epithelioid cell tumor 29.2 VIM PGR MME KIT DES CALD1
40 fasciitis 29.1 VIM ESR1 DES CD34 ACTC1
41 pancreatic adenocarcinoma 29.1 KIT IGF2 ESR1 CDK2 BCL2
42 lipomatosis, multiple 29.0 SERPINA3 KIT HMGA2 DES CD34
43 malignant fibroxanthoma 29.0 VIM SERPINA3 HMGA2 DES CD34 ACTC1
44 adenosarcoma 29.0 VIM SERPINA3 PGR MME KIT ESR1
45 leukemia, acute lymphoblastic 28.8 MME KIT CDK2 CD34 BCL2
46 myofibroma 28.7 SERPINA3 S100A1 DES CD34 CALD1
47 fibroma 28.7 VIM SERPINA3 S100A1 DES CD34 ACTC1
48 meningioma, familial 28.7 SERPINA3 PGR KIT IGF2 ESR1 CD34
49 myoma 28.6 PGR MME MED12 KIT HMGA2 ESR1
50 glomangioma 28.6 VIM S100A1 DES CD34 CALD1 ACTC1

Graphical network of the top 20 diseases related to Smooth Muscle Tumor:



Diseases related to Smooth Muscle Tumor

Symptoms & Phenotypes for Smooth Muscle Tumor

MGI Mouse Phenotypes related to Smooth Muscle Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 ACTC1 BCL2 CD34 CDK2 DES ESR1
2 cardiovascular system MP:0005385 10.14 ACTC1 BCL2 CDK2 DES ESR1 IGF2
3 homeostasis/metabolism MP:0005376 10.13 ACTC1 BCL2 CD34 CDK2 CR2 DES
4 immune system MP:0005387 10 BCL2 CCL11 CD34 CDK2 CR2 ESR1
5 integument MP:0010771 9.81 BCL2 CD34 CDK2 ESR1 IGF2 KIT
6 muscle MP:0005369 9.65 ACTC1 BCL2 CDK2 DES ESR1 IGF2
7 neoplasm MP:0002006 9.17 BCL2 CD34 CDK2 ESR1 KIT NME1

Drugs & Therapeutics for Smooth Muscle Tumor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Surgical Management of Intravenous Leiomyomatosis With Intracardiac Extension: Our Experience and Outcomes Completed NCT01707862

Search NIH Clinical Center for Smooth Muscle Tumor

Cochrane evidence based reviews: smooth muscle tumor

Genetic Tests for Smooth Muscle Tumor

Anatomical Context for Smooth Muscle Tumor

MalaCards organs/tissues related to Smooth Muscle Tumor:

40
Smooth Muscle, Breast, Uterus, Liver, Heart, Lung, B Cells

Publications for Smooth Muscle Tumor

Articles related to Smooth Muscle Tumor:

(show top 50) (show all 523)
# Title Authors PMID Year
1
[Mesenchymal uterine tumors. Leiomyomas]. 54 61
19495761 2009
2
Colorectal mesenchymal tumors - from smooth muscle tumors to stromal tumors. 54 61
18949416 2008
3
Clinicopathological characteristics of gastrointestinal mesenchymal tumors and diagnostic value of endoscopic ultrasonography. 54 61
18505417 2008
4
Immunohistochemical analysis of p16, p53, and Ki-67 expression in uterine smooth muscle tumors. 54 61
18580309 2008
5
Expression of chemokines CCL5 and CCL11 by smooth muscle tumor cells of the uterus and its possible role in the recruitment of mast cells. 54 61
17368523 2007
6
[Study of the mechanism of mast cell increase in cellular leiomyoma of uterus]. 54 61
17697600 2007
7
Expression and prognostic role of molecular markers in 99 KIT-positive gastric stromal tumors in Taiwanese. 54 61
16489674 2006
8
[Gastrointestinal stromal tumor: a clinicopathological study of 74 cases]. 54 61
15796874 2005
9
Immunohistochemical analyses of gastric stromal tumors in Taiwanese. 54 61
14691596 2003
10
Expression of desmin and smooth muscle myosin heavy chain in dermatofibromas. 54 61
12296754 2002
11
MIB-1 (Ki-67), p53, estrogen receptor, and progesterone receptor expression in uterine smooth muscle tumors. 54 61
11567229 2001
12
Analysis of KIT mutation and protein expression in fine needle aspirates of gastrointestinal stromal/smooth muscle tumors. 54 61
11127756 2000
13
Spindle cell stromal tumors of gastrointestinal tract: a histological and immunohistochemical study. 54 61
1710946 1991
14
Insulin-like growth factor gene expression in human smooth muscle tumors. 54 61
2208134 1990
15
Smooth Muscle Tumors of the Visceral Adnexal and Uterine Ligaments and Adnexal Connective Tissue: A Clinicopathologic Study of 67 Cases. 61
30702465 2020
16
Intraocular Leiomyoma: Current Concepts. 61
31923479 2020
17
Clinical experience of uterine smooth muscle tumor of uncertain malignant potential in two gynecological centers: Oncological and obstetrical aspects. 61
31927240 2020
18
Epstein-Barr Virus-Associated Smooth Muscle Tumor of the Spine After Bone Marrow Transplant: Case Report and Review of Literature. 61
31809898 2019
19
Laryngeal Epstein-Barr Virus-Associated Smooth Muscle Tumor in an Undernourished Child. 61
30120720 2019
20
Ultrasound Features of Uterine Sarcomas. 61
31094892 2019
21
Myxoid smooth muscle neoplasia of the uterus: comprehensive analysis by next-generation sequencing and nucleic acid hybridization. 61
31189997 2019
22
Intravascular Leiomyomatosis Extending to Right Atrium: A Rare Caused Syncope. 61
31743782 2019
23
Perinodular hydropic degeneration in uterine leiomyoma causing rapid enlargement and mimicking a myxoid smooth muscle tumor: Case report of a diagnostic challenge. 61
31700809 2019
24
Ultrasound appearance of intravenous leiomyomatosis: A case report. 61
31464926 2019
25
The Expression of MBD6 Is Associated with Tumor Size in Uterine Leiomyomas. 61
31313936 2019
26
Advanced 3D Imaging of Uterine Leiomyoma's Morphology by Propagation-based Phase-Contrast Microtomography. 61
31332223 2019
27
Progesterone receptor antagonist provides palliative effects for uterine leiomyoma through a Bcl-2/Beclin1-dependent mechanism. 61
31262976 2019
28
Uterine smooth muscle tumor of uncertain malignant potential: fertility and clinical outcomes. 61
31074239 2019
29
The first case of idiopathic inflammatory myopathy complicated by Epstein-Barr virus-associated smooth muscle tumor and lymphoma. 61
31211523 2019
30
Treatment response with sirolimus for a pediatric patient with an EBV-associated smooth-muscle tumor after bone marrow transplantation. 61
30614215 2019
31
Hydropic leiomyoma: a distinct variant of leiomyoma closely related to HMGA2 overexpression. 61
30292626 2019
32
[Mesenchymal and mixed uterine tumors : Current overview and practical aspects]. 61
30694356 2019
33
Secondary Leiomyosarcoma of the Lower Limb Following Uterine Smooth Muscle Tumor of Uncertain Malignant Potential. 61
31258342 2019
34
ALK-rearranged Tumors Are Highly Enriched in the STUMP Subcategory of Uterine Tumors. 61
29794871 2019
35
Transcriptome Analysis of mRNA in Uterine Leiomyoma Using Next-generation RNA Sequencing. 61
30963983 2019
36
Inflammatory myofibroblastic tumor of the uterus - case report. 61
31842556 2019
37
[Smooth muscle tumors of uncertain malignant potential]. 61
31317925 2019
38
Loss of ATRX/DAXX expression and alternative lengthening of telomeres in uterine leiomyomas. 61
30423196 2018
39
Canine Gastrointestinal Spindle Cell Tumors Efficiently Diagnosed by Tissue Microarray-Based Immunohistochemistry. 61
29807498 2018
40
A clinicopathologic review and obstetric outcome of uterine smooth muscle tumor of uncertain malignant potential (STUMP) in a single institution. 61
29902779 2018
41
Fumarate Hydratase Mutations and Alterations in Leiomyoma With Bizarre Nuclei. 61
28863073 2018
42
Deep sequencing reveals the molecular pathology characteristics between primary uterine leiomyoma and pulmonary benign metastasizing leiomyoma. 61
29484624 2018
43
Leiomyoma With Bizarre Nuclei: Clinical and Pathologic Features of 30 Patients. 61
28700441 2018
44
The selected biomarker analysis in 5 types of uterine smooth muscle tumors. 61
29258902 2018
45
Epstein-Barr virus-associated smooth muscle tumor involving the spine of an HIV-infected patient: Case report and review of the literature. 61
29605279 2018
46
Genome profiling is an efficient tool to avoid the STUMP classification of uterine smooth muscle lesions: a comprehensive array-genomic hybridization analysis of 77 tumors. 61
29327710 2018
47
The incidence of occult malignancy following uterine morcellation: A ten-year single institution experience retrospective cohort study. 61
29621658 2018
48
Review of the literature laparoscopic surgery for metastatic hepatic leiomyosarcoma associated with smooth muscle tumor of uncertain malignant potential: Case report. 61
29713398 2018
49
Morphological and immunohistochemical diversity of endometrial stromal sarcoma in rats. 61
29749998 2018
50
Ultrasound guided core needle biopsy prior to thermo ablative treatment of uterine tumors: first results. 61
29177589 2018

Variations for Smooth Muscle Tumor

Expression for Smooth Muscle Tumor

Search GEO for disease gene expression data for Smooth Muscle Tumor.

Pathways for Smooth Muscle Tumor

GO Terms for Smooth Muscle Tumor

Cellular components related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.47 VIM TMSB15A S100A1 PGR NME1 MME

Biological processes related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.83 VIM KIT HMGA2 CD34 ACTC1
2 B cell differentiation GO:0030183 9.65 KIT CR2 BCL2
3 hemopoiesis GO:0030097 9.63 KIT CD34 BCL2
4 positive regulation of phospholipase C activity GO:0010863 9.51 KIT ESR1
5 developmental pigmentation GO:0048066 9.49 KIT BCL2
6 muscle filament sliding GO:0030049 9.43 VIM DES ACTC1
7 paracrine signaling GO:0038001 9.4 PGR CD34
8 lymphoid progenitor cell differentiation GO:0002320 9.37 KIT BCL2
9 response to radiation GO:0009314 9.33 KIT CCL11 BCL2
10 mast cell chemotaxis GO:0002551 9.32 KIT CCL11
11 stem cell differentiation GO:0048863 9.13 KIT HMGA2 ESR1
12 actin filament organization GO:0007015 8.92 TMSB15A CCL11 BCL2 ACTC1

Molecular functions related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 VIM S100A1 PGR NME1 ESR1 DES
2 ATPase binding GO:0051117 9.33 S100A1 PGR ESR1
3 transcription factor binding GO:0008134 9.02 MED12 HMGA2 ESR1 CD34 BCL2

Sources for Smooth Muscle Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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