Social Phobia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SCL003 MIFTS: 49	Social Phobia Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Social Phobia

MalaCards integrated aliases for Social Phobia:

Name: Social Phobia ¹² ¹⁵

Phobia, Social ⁴⁵ ⁷⁴

Phobic Anxiety Disorder ⁷⁴

Phobia Social ⁵⁶

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Mental and behavioural disorders

Neurotic, stress-related and somatoform disorders

Phobic anxiety disorders

Social phobias

External Ids:

Disease Ontology ¹² DOID:11257

ICD9CM ³⁶ 300.23

MeSH ⁴⁵ D000072861

NCIt ⁵¹ C34927

SNOMED-CT ⁶⁹ 25501002

ICD10 ³⁴ F40.1 F40.10

UMLS ⁷⁴ C0031572 C0349231

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Summaries for Social Phobia

Disease Ontology : ¹² A phobic disorder that involves social anxiety occurring only in specific public or social situations, interactions with others or being evaluated or scrutinized by other people.

MalaCards based summary : Social Phobia, also known as phobia, social, is related to avoidant personality disorder and depression. An important gene associated with Social Phobia is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Serotonergic synapse. The drugs Vortioxetine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and testes, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Social Phobia

Diseases related to Social Phobia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)

#	Related Disease	Score	Top Affiliating Genes
1	avoidant personality disorder	31.3	MAOA SLC6A4
2	depression	31.1	HTR1A MAOA SLC6A4
3	anxiety	31.0	HTR1A HTR3A MAOA SLC6A4
4	agoraphobia	30.8	HTR1A MAOA SLC6A4
5	panic disorder	30.2	CCK HTR1A HTR3A MAOA SLC6A4
6	atypical depressive disorder	30.2	MAOA SLC6A4
7	paraphilia disorder	30.1	MAOA PRL
8	sexual disorder	30.0	HTR1A PRL SLC6A4
9	personality disorder	30.0	DRD2 HTR1A MAOA PRL SLC6A4
10	premature ejaculation	29.9	HTR1A HTR3A SLC6A4
11	borderline personality disorder	29.8	HTR1A MAOA SLC6A4
12	mental depression	29.8	HTR1A MAOA SLC6A4
13	endogenous depression	29.8	HTR1A MAOA SLC6A4
14	generalized anxiety disorder	29.7	DRD2 HTR1A HTR3A MAOA SLC6A4
15	alcohol abuse	29.7	DRD2 PRL SLC6A4
16	eating disorder	29.7	CCK DRD2 SLC6A4
17	alexithymia	29.6	DRD2 HTR1A SLC6A4
18	mood disorder	29.5	DRD2 HTR1A MAOA SLC6A4
19	drug dependence	29.5	DRD2 SLC6A4
20	bipolar disorder	29.3	DRD2 HTR1A SLC6A4
21	obsessive-compulsive disorder	29.2	DRD2 HTR1A HTR3A MAOA PRL SLC6A4
22	attention deficit-hyperactivity disorder	29.1	DRD2 HTR1A MAOA SLC6A4
23	disease of mental health	28.8	CCK DRD2 HTR1A MAOA SLC6A4
24	alcohol dependence	28.6	CCK DRD2 HTR1A HTR3A MAOA SLC6A4
25	major depressive disorder	28.5	DRD2 HTR1A HTR3A MAOA PRL SLC6A4
26	schizophrenia	28.3	CCK DRD2 HTR1A HTR3A MAOA PRL
27	mutism	10.4
28	elective mutism	10.4
29	stiff-person syndrome	10.3
30	phobia, specific	10.3
31	stuttering	10.3
32	strabismus	10.2
33	mechanical strabismus	10.2
34	dysthymic disorder	10.2	MAOA SLC6A4
35	autism	10.2
36	body dysmorphic disorder	10.2
37	separation anxiety disorder	10.2
38	essential tremor	10.2
39	tremor	10.2
40	paranoid schizophrenia	10.1	MAOA SLC6A4
41	psychosexual disorder	10.1	HTR1A SLC6A4
42	neurofibromatosis, type ii	10.1
43	torticollis	10.1
44	retinal dystrophy, iris coloboma, and comedogenic acne syndrome	10.1
45	speech and communication disorders	10.1
46	cervical dystonia	10.1
47	schizophrenia 5	10.1	HTR1A HTR3A
48	stereotypic movement disorder	10.1	CCK PRL
49	rumination disorder	10.1	HTR1A HTR3A
50	motion sickness	10.0	HTR1A HTR3A

Comorbidity relations with Social Phobia via Phenotypic Disease Network (PDN):

Anxiety

Dysthymic Disorder

Graphical network of the top 20 diseases related to Social Phobia:

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Symptoms & Phenotypes for Social Phobia

GenomeRNAi Phenotypes related to Social Phobia according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00381-A-1	9.28	HTR1A HTR3A SLC6A4
2	Decreased viability	GR00381-A-3	9.28	HTR1A HTR3A SLC6A4
3	Decreased viability	GR00402-S-2	9.28	HTR1A HTR3A SLC6A4

MGI Mouse Phenotypes related to Social Phobia:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.73	DRD2 HTR1A HTR3A MAOA PRL SLC6A4
2	endocrine/exocrine gland	MP:0005379	9.55	CCK DRD2 HTR3A PRL SLC6A4
3	homeostasis/metabolism	MP:0005376	9.5	CCK DRD2 HTR1A HTR3A MAOA PRL
4	nervous system	MP:0003631	9.17	CCK DRD2 HTR1A HTR3A MAOA PRL

Sources

Drugs & Therapeutics for Social Phobia

Drugs for Social Phobia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 196)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Vortioxetine

Approved, Investigational

Phase 4

508233-74-7

9966051

Norepinephrine

Approved

Phase 4,Phase 3,Not Applicable

51-41-2

439260

Citalopram

Approved

Phase 4,Phase 2,Phase 1,Not Applicable

59729-33-8

2771

Paroxetine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

61869-08-7

43815

Dopamine

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

62-31-7, 51-61-6

681

Ketamine

Approved, Vet_approved

Phase 4,Early Phase 1

6740-88-1

3821

Clonazepam

Approved, Illicit

Phase 4

1622-61-3

2802

Sertraline

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

79617-96-2

68617

Cycloserine

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

68-41-7

6234 401

Tiagabine

Approved, Investigational

Phase 4

115103-54-3

60648

Aripiprazole

Approved, Investigational

Phase 4

129722-12-9

60795

Acamprosate

Approved, Investigational

Phase 4

77337-76-9

71158

Ethanol

Approved

Phase 4,Phase 2,Not Applicable

64-17-5

702

Levetiracetam

Approved, Investigational

Phase 4,Phase 2

102767-28-2

441341

Guanfacine

Approved, Investigational

Phase 4,Phase 2

29110-47-2

3519

Propranolol

Approved, Investigational

Phase 4,Phase 2,Not Applicable

525-66-6

4946

Methylphenidate

Approved, Investigational

Phase 4,Not Applicable

113-45-1

4158

Topiramate

Approved

Phase 4

97240-79-4

5284627

Gabapentin

Approved, Investigational

Phase 4

60142-96-3

3446

Midazolam

Approved, Illicit

Phase 4

59467-70-8

4192

Acetylcholine

Approved, Investigational

Phase 4

51-84-3

187

Serotonin 5-HT1 Receptor Agonists

Phase 4,Not Applicable

Serotonin 5-HT3 Receptor Antagonists

Phase 4

Serotonin Receptor Agonists

Phase 4,Phase 3,Not Applicable

Tranquilizing Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Anti-Anxiety Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Neurotransmitter Uptake Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Psychotropic Drugs

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Neurotransmitter Agents

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable

Serotonin Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antidepressive Agents

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable

Central Nervous System Depressants

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable

Serotonin Uptake Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Serotonin Antagonists

Phase 4,Phase 2

Serotonin and Noradrenaline Reuptake Inhibitors

Phase 4,Phase 3,Not Applicable

Antidepressive Agents, Second-Generation

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Venlafaxine Hydrochloride

Phase 4,Phase 3,Not Applicable

Parasympatholytics

Phase 4,Phase 2,Phase 1,Not Applicable

Muscarinic Antagonists

Phase 4,Phase 2,Phase 1,Not Applicable

Antiparkinson Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Cholinergic Antagonists

Phase 4,Phase 2,Phase 1,Not Applicable

Autonomic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Cholinergic Agents

Phase 4,Phase 2,Phase 1,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable

Cytochrome P-450 CYP2D6 Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Dopamine Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Excitatory Amino Acid Antagonists

Phase 4,Phase 3,Phase 2,Early Phase 1

Analgesics

Phase 4,Phase 3,Early Phase 1,Not Applicable

Excitatory Amino Acids

Phase 4,Phase 3,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 365)

#	Name	Status	NCT ID	Phase	Drugs
1	Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disorder	Unknown status	NCT02294305	Phase 4	Vortioxetine;Placebo
2	Improving Treatment Outcomes in Pharmacotherapy of Generalized Social Anxiety Disorder	Completed	NCT00282828	Phase 4	Sertraline;Venlafaxine;Placebo;Clonazepam
3	The Use of Quetiapine (Seroquel) in the Treatment of Social Phobia: Public Speaking Environment	Completed	NCT00407199	Phase 4	quetiapine
4	D-Cycloserine Enhancement of Exposure in Social Phobia	Completed	NCT00633984	Phase 4	D-Cycloserine;Placebo
5	Nefazodone in the Treatment of Social Phobia	Completed	NCT00231348	Phase 4	Nefazodone
6	12-Week Study of Pristiq (Desvenlafaxine) Social Anxiety Disorder	Completed	NCT01316302	Phase 4	Pristiq;Placebo
7	Study To Evaluate The Effects Of Gabitril™ In Patients With Social Anxiety Disorder	Completed	NCT00208741	Phase 4	Gabitril
8	Escitalopram in Patients With Social Anxiety Disorder	Completed	NCT00902226	Phase 4	Escitalopram
9	Adjunctive Quetiapine in the Treatment of Refractory Social Anxiety Disorder in Adults	Completed	NCT01224067	Phase 4	Quetiapine
10	Paroxetine for Comorbid Social Anxiety Disorder and Alcoholism	Completed	NCT00246441	Phase 4	Paroxetine;Placebo
11	Placebo-Controlled Study of Atomoxetine Hydrochloride in the Treatment of Adults With ADHD and Comorbid Social Anxiety Disorder	Completed	NCT00190879	Phase 4	Atomoxetine hydrochloride;placebo
12	RCT of Cognitive Therapy, Paroxetine, Combined CT and Paroxetine and Placebo	Completed	NCT00184106	Phase 4	Seroxat, Cognitive therapy, Seroxat+ cognitive therapy
13	Primary Care Intervention Strategy for Anxiety Disorders	Completed	NCT00347269	Phase 4	Psychotropic medication optimization
14	Aripiprazole for the Treatment of Schizophrenia With Co-Morbid Social Anxiety	Completed	NCT00177008	Phase 4	Aripiprazole
15	Acamprosate in Alcoholics With Comorbid Anxiety or Depression	Completed	NCT00330174	Phase 4	Acamprosate
16	Effectiveness of Levetiracetam in the Treatment of Body Dysmorphic Disorder	Completed	NCT00265109	Phase 4	Levetiracetam
17	Lisdexamfetamine Dimesylate in the Treatment of Adult ADHD With Anxiety Disorder Comorbidity	Completed	NCT01863459	Phase 4	Lisdexamfetamine Dimesylate;placebo
18	Efficacy of Adding Topiramate to Current Treatment in Treatment-Resistant Generalized Social Phobia (GSP)	Recruiting	NCT00182455	Phase 4	Topiramate;Placebo
19	Gabapentin for Pain Management During Dilation and Evacuation	Recruiting	NCT03635905	Phase 4	Gabapentin;Placebo
20	Treatments for Anxiety: Meditation and Escitalopram	Recruiting	NCT03522844	Phase 4	Escitalopram
21	Guanfacine Extended Release and Mindfulness Skills Therapy	Recruiting	NCT03258476	Phase 4	Guanfacine Extended Release;Placebo
22	Brief Intervention to Reduce Fear of Public Speaking	Active, not recruiting	NCT02790736	Phase 4	propranolol;Placebo
23	Ketamine Infusion for Adolescent Depression and Anxiety	Active, not recruiting	NCT02579928	Phase 4	Ketamine;Midazolam
24	A Study to Evaluate the Benefit of Octagam 5%® in Subjects With Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)	Active, not recruiting	NCT03348618	Phase 4
25	A 14 Week, Randomized, Placebo-Controlled Cross-Over Study of Methylphenidate Hydrochloride Controlled Release Capsules in Adult ADHD With and Without Anxiety Disorder Comorbidity	Not yet recruiting	NCT03785223	Phase 4	Methylphenidate Hydrochloride Controlled-Release Capsules;Placebo Capsule
26	Clinical Utility of Pharmacogenomics of Psychotropic Medications	Not yet recruiting	NCT03907124	Phase 4	Genetically-guided treatment with FDA-approved psychotropic drugs;Treatment as usual (TAU)
27	A Study of the Efficacy of Botox in the Treatment of Social Anxiety Disorder	Terminated	NCT03078270	Phase 4	botulinum toxin A
28	Sertraline in Generalized Social Phobia With Co-Occurring Anxiety and Mood Disorders	Terminated	NCT00182533	Phase 4	Sertraline;Placebo
29	Transfer of Manualized Cognitive-Behavioral Therapy (CBT) for Social Phobia Into Clinical Practice	Unknown status	NCT01388231	Phase 2, Phase 3
30	Treatment of Social Phobia and Panic Disorder in Adults	Completed	NCT00619138	Phase 3
31	Residential Cognitive and Interpersonal Therapy for Social Phobia	Completed	NCT00326430	Phase 2, Phase 3
32	Treatment of Childhood Social Phobia	Completed	NCT00043537	Phase 3	Fluoxetine;Pill Placebo
33	A Comparison Between Internet Therapy and Group Therapy for Social Phobia - A Trial Using Cognitive Behavioural Therapy	Completed	NCT00564967	Phase 3
34	Effect of D-cycloserine Plus Cognitive Behavioral Therapy on People With Social Phobia	Completed	NCT00515879	Phase 3	D-cycloserine;Placebo
35	Quetiapine in Social Anxiety Disorder	Completed	NCT00215254	Phase 2, Phase 3	quetiapine
36	Social Anxiety Disorder Study Of Paroxetine	Completed	NCT00318669	Phase 3	Paroxetine hydrochloride hydrate
37	Feasibility Study of PH94B Nasal Spray for Acute Treatment of Social Anxiety Disorder (SAD)	Completed	NCT02622958	Phase 3	PH94B
38	Flushing in Social Anxiety Disorder on Seroquel	Completed	NCT00773162	Phase 3	Seroquel;Sugar Pill
39	Efficacy and Tolerability of Atomoxetine (Strattera) in Adult Patients With Generalized Social Anxiety Disorder	Completed	NCT00260533	Phase 2, Phase 3	atomoxetine;placebo
40	Adding Cognitive Behavioral Therapy to Drug Treatment for Social Anxiety Disorder	Completed	NCT00074802	Phase 3	Paroxetine
41	Yohimbine to Enhance Cognitive Behavioral Therapy (CBT) for Social Anxiety	Completed	NCT00958880	Phase 3	Yohimbine Hydrochloride;Sugar Pill
42	Study Evaluating Venlafaxine ER in Children and Adolescents With Social Anxiety Disorder	Completed	NCT00238719	Phase 3	Venlafaxine ER
43	Long-term Study Of Paroxetine in Women and Men	Completed	NCT00264654	Phase 3	BRL29060A;paroxetine hydrochloride hydrate
44	Duloxetine for Social Anxiety Disorder: Prediction of Long Term Outcome	Completed	NCT00114127	Phase 3	Duloxetine;Duloxetine;Placebo
45	St. John's Wort for the Treatment of Generalized Social Anxiety Disorder (GSAD)	Completed	NCT00118833	Phase 2, Phase 3	Hypericum perforatum (St. John's wort)
46	A Systems Level Intervention for Unemployed Persons With Social Anxiety Disorder	Completed	NCT01654510	Phase 2, Phase 3
47	A 10 Week Open-Label Pilot Study to Evaluate the Effectiveness and Safety of Memantine(Namenda) as Augmentation Therapy in Patients With Generalized Anxiety Disorder	Completed	NCT00411398	Phase 3	Namenda/Memantine
48	Treatment for Anxiety in Children	Completed	NCT00000389	Phase 3	Fluvoxamine
49	Computerized Cognitive Behavioral Therapy for Childhood Anxiety in Community Health Centers	Completed	NCT01416805	Phase 3
50	Child and Adolescent Anxiety Disorders (CAMS)	Completed	NCT00052078	Phase 3	Sertraline (SRT);Placebo

Search NIH Clinical Center for Social Phobia

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :

gabapentin

gabapentin enacarbil

paroxetine

paroxetine hydrochloride

Cochrane evidence based reviews: phobia, social

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Genetic Tests for Social Phobia

Sources

Anatomical Context for Social Phobia

MalaCards organs/tissues related to Social Phobia:

⁴²

Brain, Pituitary, Testes, Colon, Amygdala, Heart, Cortex

Sources

Publications for Social Phobia

Articles related to Social Phobia:

(show top 50) (show all 1208)

#	Title	Authors	Year
1	Comparing Scores From Full Length, Short Form, and Adaptive Tests of the Social Interaction Anxiety and Social Phobia Scales. ( 30873852 )	Sunderland M...Slade T	2019
2	Measurement equivalence of the Social Interaction Anxiety Scale (SIAS) and Social Phobia Scale (SPS) across individuals with social anxiety disorder from Japanese and Australian sociocultural contexts. ( 30243196 )	Wong QJJ...Rapee RM	2019
3	Associations between adolescent social phobia, sickness absence and unemployment: a prospective study of twins in Sweden. ( 30879025 )	Amin R...Narusyte J	2019
4	Examination of Executive Function and Social Phobia Among Female College-Aged Students With Celiac Disease. ( 30272808 )	Arnone JM...Conti RP	2019
5	Psychometric Evaluation of the Social Phobia Inventory and the Mini-Social Phobia Inventory in a Swedish University Student Sample. ( 29375026 )	M?rtberg E...Jansson Fr?jmark M	2019
6	Prevalence and associated factors for social phobia among school-going adolescents in a rural area of Puducherry, South India. ( 30398971 )	Yuvaraj K...Subitha L	2018
7	Comorbid social phobia does not predict the outcome in alcohol use disorder outpatient treatment. ( 30384322 )	Mellentin AI...S?gaard Nielsen A	2018
8	Optimal Cut Points for Remission and Response for the German Version of the Social Phobia Anxiety Inventory (SPAI). ( 29862918 )	von Glischinski M...Hirschfeld G	2018
9	Well-being in major depression and social phobia with and without comorbidity. ( 30487925 )	Wersebe H...Gloster AT	2018
10	Avoidant personality disorder and social phobia: Does mindreading make the difference? ( 29096207 )	Pellecchia G...Procacci M	2018
11	Bigger is better: Full-length versions of the Social Interaction Anxiety Scale and Social Phobia Scale outperform short forms at assessing treatment outcome. ( 30070558 )	Erceg-Hurn DM...McEvoy PM	2018
12	Mini - social phobia inventory (mini-SPIN): psychometric properties and population based norms of the German version. ( 29178857 )	Wiltink J...Zwerenz R	2017
13	Daily fluctuation of emotions and memories thereof: Design and methods of an experience sampling study of major depression, social phobia, and controls. ( 28948700 )	Gloster AT...Lieb R	2017
14	Social phobia, depression and eating disorders during middle adolescence: longitudinal associations and treatment seeking. ( 28868945 )	Ranta K...Marttunen M	2017
15	Comorbidity of schizophrenia and social phobia - impact on quality of life, hope, and personality traits: a cross sectional study. ( 28831256 )	Vrbova K...Holubova M	2017
16	Identifying sub-categories of social fears using an alternative factor analytic structure of the Social Phobia and Anxiety Inventory. ( 28236783 )	Panayiotou G...Neophytou K	2017
17	Confirmatory Factor Analysis of the Combined Social Phobia Scale and Social Interaction Anxiety Scale: Support for a Bifactor Model. ( 28210232 )	Gomez R...Watson SD	2017
18	Factor solutions of the Social Phobia Scale (SPS) and the Social Interaction Anxiety Scale (SIAS) in a Swedish population. ( 27894213 )	M?rtberg E...?st LG	2017
19	Autonomic markers associated with generalized social phobia symptoms: heart rate variability and salivary alpha-amylase. ( 27892761 )	Garc?a-Rubio MJ...G?mez-Amor J	2017
20	Examination of the Correlation Between Internet Addiction and Social Phobia in Adolescents. ( 27561297 )	Yayan EH...?zel ?zcan ?	2017
21	Assimilation, reflexivity, and therapist responsiveness in group psychotherapy for social phobia: A case study. ( 27092848 )	Penttinen H...Hartikainen K	2017
22	Community-Based Validation of the Social Phobia Screener (SOPHS). ( 26939801 )	Batterham PJ...Christensen H	2017
23	Collaborative care for panic disorder, generalised anxiety disorder and social phobia in general practice: study protocol for three cluster-randomised, superiority trials. ( 28814317 )	Curth NK...Eplov LF	2017
24	Hypochondriasis Differs From Panic Disorder and Social Phobia: Specific Processes Identified Within Patient Groups. ( 27805984 )	H?fling V...Weck F	2017
25	Depression and social phobia in essential tremor and Parkinson's disease. ( 28948077 )	Smeltere L...Erts R	2017
26	Developmental Differences in Functioning in Youth With Social Phobia. ( 26630122 )	Hoff AL...Piacentini J	2017
27	Social Phobia Is Associated with Delayed Onset of Chickenpox, Measles, and Mumps Infections. ( 28082921 )	Ajdacic-Gross V...Preisig M	2016
28	The effect of Interaction Anxiousness Scale and Brief Social Phobia Scale for screening social anxiety disorder in college students: a study on discriminative validity. ( 27935389 )	Cao J...Peng T	2016
29	Social Phobia: The Role of In-Situation Safety Behaviors in Maintaining Anxiety and Negative Beliefs - Republished Article. ( 27816079 )	Wells A...Gelder M	2016
30	Retracted: Combined Case of Blood-Injury-Injection Phobia and Social Phobia: Behavior Therapy Management and Effectiveness through Tilt Test. ( 27722005 )	Case Reports In Psychiatry	2016
31	No effects of psychosocial stress on memory retrieval in non-treated young students with Generalized Social Phobia. ( 27464065 )	Esp?n L...G?mez-Amor J	2016
32	Attentional mechanisms of social perception are biased in social phobia. ( 27131909 )	Boll S...Gamer M	2016
33	Psychometric properties of the Mini-Social Phobia Inventory (Mini-SPIN) in a large online treatment-seeking sample. ( 27046641 )	Fogliati VJ...Dear BF	2016
34	Internet-based CBT for social phobia and panic disorder in a specialised anxiety clinic in routine care: Results of a pilot randomised controlled trial. ( 30135794 )	Mathiasen K...Rosenberg NK	2016
35	Selective Mutism: The Fraternal Twin of Childhood Social Phobia. ( 27089281 )	Gensthaler A...Schwenck C	2016
36	Attachment styles in patients with avoidant personality disorder compared with social phobia. ( 26332087 )	Eikenaes I...Wilberg T	2016
37	Baseline Patient Characteristics Predicting Outcome and Attrition in Cognitive Therapy for Social Phobia: Results from a Large Multicentre Trial. ( 25504802 )	Hoyer J...Leibing E	2016
38	Social Phobia and Educational and Interpersonal Impairments in Adolescence: A Prospective Study. ( 26514560 )	Ranta K...Marttunen M	2016
39	Virtual reality exposure using three-dimensional images for the treatment of social phobia. ( 26561376 )	Gebara CM...Lotufo-Neto F	2016
40	Social phobia and avoidant personality disorder: similar but different? ( 23398095 )	Lampe L...Sunderland M	2015
41	Avoidant personality disorder versus social phobia: the significance of childhood neglect. ( 25815817 )	Eikenaes I...Wilberg T	2015
42	Correction: Avoidant Personality Disorder versus Social Phobia: The Significance of Childhood Neglect. ( 25978045 )	Eikenaes I...Wilberg T	2015
43	Bruxism and oral parafunctional hyperactivity in social phobia outpatients. ( 25238249 )	Hermesh H...Winocur E	2015
44	The neuroanatomical basis of panic disorder and social phobia in schizophrenia: a voxel based morphometric study. ( 25774979 )	Picado M...Bulbena A	2015
45	Correction: The neuroanatomical basis of panic disorder and social phobia in schizophrenia: a voxel based morphometric study. ( 25906143 )	Picado M...Bulbena A	2015
46	Comparison of automatical thoughts among generalized anxiety disorder, major depressive disorder and generalized social phobia patients. ( 26241548 )	G?l AI...Inanir S	2015
47	Social anxiety disorders in clinical practice: differentiating social phobia from avoidant personality disorder. ( 26129819 )	Lampe L	2015
48	Altered emotion regulation capacity in social phobia as a function of comorbidity. ( 24813437 )	Burklund LJ...Lieberman MD	2015
49	Children with social phobia have lower quality friendships than children with other anxiety disorders. ( 25337769 )	Baker JR...Hudson JL	2015
50	Social phobia among long-term internally displaced persons: An epidemiological study of adults in two internally displaced person settlements in Sudan. ( 25540300 )	Salah TT...Hauff E	2015

Sources

Genes for Social Phobia

Genes related to Social Phobia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MAOA	Monoamine Oxidase A	Protein Coding	31.58	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	8313403 10361959 8619339 (more) 9534836 16160936
2	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	26.84	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	9925179 15158011 12457263 (more) 7711158
3	HTR3A	5-Hydroxytryptamine Receptor 3A	Protein Coding	24.26	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	9397424
4	CCK	Cholecystokinin	Protein Coding	20.27	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	DRD2	Dopamine Receptor D2	Protein Coding	19.09	Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15538306 12140123
6	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	17.66	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶	15538306
7	PRL	Prolactin	Protein Coding	17.6	GeneCards inferred via : Publications (show sections)

Sources

Variations for Social Phobia

Sources

Expression for Social Phobia

Search GEO for disease gene expression data for Social Phobia.

Sources

Pathways for Social Phobia

Pathways related to Social Phobia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.67	HTR1A HTR3A MAOA SLC6A4
2	Serotonergic synapse ³⁸	11.32	HTR1A HTR3A MAOA SLC6A4
3	Monoamine Transport ¹ Show member pathways Serotonin Transporter Activity ¹	10.96	MAOA SLC6A4
4	Neurotransmitter Clearance In The Synaptic Cleft ⁶⁷ Show member pathways Dopamine clearance from the synaptic cleft ⁶⁷ Enzymatic degradation of dopamine by COMT ⁶⁷ Enzymatic degradation of Dopamine by monoamine oxidase ⁶⁷ L-dopa degradation ¹ melatonin degradation II ¹ Metabolism of serotonin ⁶⁷ Serotonin clearance from the synaptic cleft ⁶⁷	10.69	MAOA SLC6A4
5	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics ⁶²	10.37	HTR1A HTR3A MAOA SLC6A4

Sources

GO Terms for Social Phobia

Cellular components related to Social Phobia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.62	DRD2 HTR1A HTR3A SLC6A4
2	dendrite	GO:0030425	9.43	CCK DRD2 HTR1A
3	axon	GO:0030424	9.33	CCK DRD2 HTR3A
4	integral component of presynaptic membrane	GO:0099056	9.13	DRD2 HTR3A SLC6A4
5	integral component of postsynaptic membrane	GO:0099055	8.8	DRD2 HTR3A SLC6A4

Biological processes related to Social Phobia according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	axonogenesis	GO:0007409	9.49	CCK DRD2
2	memory	GO:0007613	9.43	CCK SLC6A4
3	excitatory postsynaptic potential	GO:0060079	9.4	DRD2 HTR3A
4	visual learning	GO:0008542	9.37	CCK DRD2
5	response to drug	GO:0042493	9.32	DRD2 SLC6A4
6	response to cocaine	GO:0042220	9.26	DRD2 HTR3A
7	circadian rhythm	GO:0007623	9.18	SLC6A4
8	response to nutrient	GO:0007584	9.16	SLC6A4
9	vasoconstriction	GO:0042310	9.16	HTR1A SLC6A4
10	response to ethanol	GO:0045471	8.96	DRD2 HTR3A
11	serotonin receptor signaling pathway	GO:0007210	8.62	HTR1A HTR3A

Molecular functions related to Social Phobia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serotonin binding	GO:0051378	8.8	HTR1A HTR3A SLC6A4

Sources

Sources for Social Phobia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Social Phobia

Aliases & Classifications for Social Phobia

MalaCards integrated aliases for Social Phobia:

Classifications:

External Ids:

Summaries for Social Phobia

Related Diseases for Social Phobia

Diseases related to Social Phobia via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Social Phobia via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Social Phobia:

Symptoms & Phenotypes for Social Phobia

GenomeRNAi Phenotypes related to Social Phobia according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Social Phobia:

Drugs & Therapeutics for Social Phobia

Drugs for Social Phobia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Cochrane evidence based reviews: phobia, social

Genetic Tests for Social Phobia

Anatomical Context for Social Phobia

MalaCards organs/tissues related to Social Phobia:

Publications for Social Phobia

Articles related to Social Phobia:

Genes for Social Phobia

Genes related to Social Phobia (0 elite genes):

Variations for Social Phobia

Expression for Social Phobia

Pathways for Social Phobia

Pathways related to Social Phobia according to GeneCards Suite gene sharing:

GO Terms for Social Phobia

Cellular components related to Social Phobia according to GeneCards Suite gene sharing:

Biological processes related to Social Phobia according to GeneCards Suite gene sharing:

Molecular functions related to Social Phobia according to GeneCards Suite gene sharing:

Sources for Social Phobia

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :