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MCID: SCL003
MIFTS: 48

Social Phobia

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Social Phobia

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MalaCards integrated aliases for Social Phobia:

Name: Social Phobia 12 15
Phobia, Social 43 71
Phobic Anxiety Disorder 71
Phobia Social 54

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:11257
ICD9CM 34 300.23
MeSH 43 D000072861
NCIt 49 C34927
SNOMED-CT 67 25501002
ICD10 32 F40 F40.1 F40.9
UMLS 71 C0031572 C0349231
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Summaries for Social Phobia

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Disease Ontology : 12 A phobic disorder that involves social anxiety occurring only in specific public or social situations, interactions with others or being evaluated or scrutinized by other people.

MalaCards based summary : Social Phobia, also known as phobia, social, is related to depression and avoidant personality disorder. An important gene associated with Social Phobia is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Serotonergic synapse. The drugs Topiramate and Vortioxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and amygdala, and related phenotypes are Decreased viability and Decreased viability

Sources

Related Diseases for Social Phobia

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Diseases related to Social Phobia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Related Disease Score Top Affiliating Genes
1 depression 31.9 SLC6A4 MAOA HTR1A
2 avoidant personality disorder 31.7 WASF2 WASF1 SLC6A4 MAOA
3 personality disorder 31.2 SLC6A4 PRL MAOA HTR3A HTR1A DRD2
4 body dysmorphic disorder 31.1 SLC6A4 OXT MAOA
5 generalized anxiety disorder 31.1 SLC6A4 PRODH MAOA HTR3A HTR1A DRD2
6 eating disorder 31.1 SLC6A4 DRD2 COMT CCK
7 neurotic disorder 30.9 SLC6A4 MAOA HTR1A
8 delusional disorder 30.9 PRL HTR1A DRD2
9 panic disorder 30.9 TACR1 SLC6A4 PTK7 PRL MAOA HTR3A
10 drug dependence 30.8 SLC6A4 HTR3A DRD2
11 somatization disorder 30.8 SLC6A4 OXT
12 atypical depressive disorder 30.7 SLC6A4 SERPINA3 MAOA HTR1A
13 alcohol use disorder 30.6 WASF2 WASF1 SLC6A4 HTR3A HTR1A DRD2
14 mood disorder 30.6 TACR1 SLC6A4 PRODH MAOA HTR3A HTR1A
15 major depressive disorder 30.5 TACR1 SLC6A4 PRL OXT MAOA HTR3A
16 bruxism 30.5 SLC6A4 HTR1A DRD2
17 premature ejaculation 30.5 SLC6A4 OXT HTR3A HTR1A COMT
18 hypochondriasis 30.5 SLC6A4 IVL HTR3A HTR1A
19 dependent personality disorder 30.5 WASF2 WASF1
20 movement disease 30.4 SERPINA3 PRODH DRD2
21 anxiety 30.4 SLC6A4 PTK7 PRODH PRL OXT MIR485
22 cocaine dependence 30.4 SLC6A4 PRL DRD2 COMT
23 obsessive-compulsive personality disorder 30.4 WASF2 WASF1 SLC6A4 COMT
24 sexual disorder 30.4 SLC6A4 SERPINA3 PRL OXT HTR3A HTR1A
25 alexithymia 30.4 SLC6A4 OXT HTR1A DRD2 COMT
26 obsessive-compulsive disorder 30.3 SLC6A4 PTK7 PRL OXT MAOA HTR3A
27 conduct disorder 30.3 SLC6A4 NBAS MAOA DRD2 COMT
28 cyclothymic disorder 30.3 DRD2 COMT CGAS
29 agoraphobia 30.3 WASF2 WASF1 SLC6A4 PTK7 NBAS MAOA
30 alcohol dependence 30.3 TACR1 SLC6A4 PRL OXT MAOA HTR3A
31 paraphilia disorder 30.2 OXT MAOA
32 separation anxiety disorder 30.2 WASF2 WASF1 SLC6A4 OXT NBAS CGAS
33 cannabis dependence 30.1 WASF2 WASF1 DRD2 COMT
34 gilles de la tourette syndrome 30.0 SLC6A4 MAOA HTR3A HTR1A DRD2 COMT
35 anorexia nervosa 30.0 SLC6A4 PRL OXT MAOA HTR1A COMT
36 post-traumatic stress disorder 30.0 SLC6A4 MAOA HTR1A DRD2 COMT CAT
37 impulse control disorder 29.9 WASF1 SLC6A4 MAOA HTR1A DRD2 COMT
38 schizoaffective disorder 29.9 SLC6A4 PRODH PRL HTR1A DRD2 COMT
39 schizophreniform disorder 29.9 PRODH PRL DRD2 COMT CGAS
40 bipolar disorder 29.9 TACR1 SLC6A4 PRODH PRL MAOA HTR3A
41 borderline personality disorder 29.9 SLC6A4 PRL MAOA HTR3A HTR1A DRD2
42 schizotypal personality disorder 29.9 WASF2 WASF1 PRODH DRD2 COMT
43 substance abuse 29.8 WASF2 WASF1 SLC6A4 SERPINA3 PRODH PRL
44 substance dependence 29.8 WASF2 WASF1 SLC6A4 SERPINA3 MAOA DRD2
45 mental depression 29.8 WASF2 WASF1 SLC6A4 SERPINA3 PRODH OXT
46 bulimia nervosa 29.7 SLC6A4 PRL OXT MAOA HTR3A DRD2
47 attention deficit-hyperactivity disorder 29.7 TACR1 SLC6A4 PRODH PRL OXT MAOA
48 oppositional defiant disorder 29.7 WASF2 WASF1 SLC6A4 MAOA DRD2 COMT
49 autism spectrum disorder 29.6 SLC6A4 PRODH OXT MAOA DRD2 COMT
50 endogenous depression 29.6 WASF1 TACR1 SLC6A4 PRL OXT MAOA

Comorbidity relations with Social Phobia via Phenotypic Disease Network (PDN):


Anxiety Dysthymic Disorder

Graphical network of the top 20 diseases related to Social Phobia:



Diseases related to Social Phobia
Sources

Symptoms & Phenotypes for Social Phobia

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GenomeRNAi Phenotypes related to Social Phobia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00249-S 9.28 SLC6A4
2 Decreased viability GR00381-A-1 9.28 HTR1A HTR3A SLC6A4
3 Decreased viability GR00381-A-3 9.28 HTR1A HTR3A SLC6A4
4 Decreased viability GR00402-S-2 9.28 HTR1A HTR3A

MGI Mouse Phenotypes related to Social Phobia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 CGAS COMT DRD2 HTR1A HTR3A MAOA
2 homeostasis/metabolism MP:0005376 9.86 CAT CCK CGAS COMT DRD2 HTR1A
3 cardiovascular system MP:0005385 9.85 COMT DRD2 HTR1A MAOA NBAS OXT
4 nervous system MP:0003631 9.5 CCK COMT DRD2 HTR1A HTR3A MAOA
Sources

Drugs & Therapeutics for Social Phobia

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Drugs for Social Phobia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 130)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 4 97240-79-4 5284627
2
Vortioxetine Approved, Investigational Phase 4 508233-74-7 9966051
3
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
4
Norepinephrine Approved Phase 4 51-41-2 439260
5
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
6
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
7
Tiagabine Approved, Investigational Phase 4 115103-54-3 60648
8
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
9
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
10
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
11
Citalopram Approved Phase 4 59729-33-8 2771
12
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
13
Propranolol Approved, Investigational Phase 4 525-66-6 4946
14
Sertraline Approved Phase 4 79617-96-2 68617
15
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
16 Hypoglycemic Agents Phase 4
17 Serotonin 5-HT3 Receptor Antagonists Phase 4
18 Cytochrome P-450 Enzyme Inhibitors Phase 4
19 Anticonvulsants Phase 4
20 Serotonin 5-HT1 Receptor Agonists Phase 4
21 Serotonin Receptor Agonists Phase 4
22 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
23 Desvenlafaxine Succinate Phase 4 386750-22-7
24 Quetiapine Fumarate Phase 4 111974-72-2
25 Antipsychotic Agents Phase 4
26 GABA Modulators Phase 4
27 Atomoxetine Hydrochloride Phase 4
28 Venlafaxine Hydrochloride Phase 4
29 Analgesics Phase 4
30 Dopamine Antagonists Phase 4
31 Dopamine agonists Phase 4
32 Excitatory Amino Acid Antagonists Phase 4
33 Neuroprotective Agents Phase 4
34 Protective Agents Phase 4
35 Dopamine Agents Phase 4
36 Central Nervous System Stimulants Phase 4
37 Antihypertensive Agents Phase 4
38 Adrenergic Agents Phase 4
39 Adrenergic Antagonists Phase 4
40 Adrenergic beta-Antagonists Phase 4
41 Vasodilator Agents Phase 4
42 Anti-Arrhythmia Agents Phase 4
43 Neurotransmitter Agents Phase 4
44 Antidepressive Agents Phase 4
45 Serotonin Uptake Inhibitors Phase 4
46 Psychotropic Drugs Phase 4
47 Cholinergic Agents Phase 4
48 abobotulinumtoxinA Phase 4
49 Botulinum Toxins, Type A Phase 4
50 Botulinum Toxins Phase 4

Interventional clinical trials:

(show top 50) (show all 293)
# Name Status NCT ID Phase Drugs
1 Topiramate Augmentation to a Selective Serotonin Re-uptake Inhibitor (SSRI) in Treatment-Resistant Generalized Social Phobia: A Double-Blind Placebo -Controlled Trial. Unknown status NCT00182455 Phase 4 Topiramate;Placebo
2 Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disorder Unknown status NCT02294305 Phase 4 Vortioxetine;Placebo
3 Nefazodone in the Treatment of Social Phobia: Functional Brain Imaging and Neuroendocrine Correlates Completed NCT00231348 Phase 4 Nefazodone
4 A 12-Week Double-Blind, Placebo-Controlled, Flexible-Dose Trial of Pristiq® (Desvenlafaxine) Extended-Release Tablets in Generalized Social Anxiety Disorder Completed NCT01316302 Phase 4 Pristiq;Placebo
5 The Use of Quetiapine (Seroquel) in the Treatment of Social Phobia: Effects on Cue Reactivity in Response to Virtual Reality Public Speaking Environment Completed NCT00407199 Phase 4 quetiapine
6 Improving Outcomes in Pharmacotherapy of Social Phobia Completed NCT00282828 Phase 4 Sertraline;Venlafaxine;Placebo;Clonazepam
7 D-Cycloserine Enhancement of Exposure in Social Phobia Completed NCT00633984 Phase 4 D-Cycloserine;Placebo
8 Phase IV Placebo-Controlled Study of Atomoxetine Hydrochloride in the Treatment of Adults With ADHD and Comorbid Social Anxiety Disorder Completed NCT00190879 Phase 4 Atomoxetine hydrochloride;placebo
9 Paroxetine for Comorbid Social Anxiety Disorder and Alcoholism Completed NCT00246441 Phase 4 Paroxetine;Placebo
10 Efficacy and Safety of Escitalopram in Patients With Social Anxiety Disorder; Open-label, One Arm Postmarketing Study in Russia Completed NCT00902226 Phase 4 Escitalopram
11 Aripiprazole for the Treatment of Schizophrenia With Co-Morbid Social Anxiety Completed NCT00177008 Phase 4 Aripiprazole
12 A 12-Week Open-Label Study Followed By A 24-Week Double-Blind Discontinuation Exploratory Study To Evaluate The Effects Of Gabitrilâ„¢ (Tiagabine Hydrochloride) In Patients With Social Anxiety Disorder (SAD) Completed NCT00208741 Phase 4 Gabitril
13 A Double-Blind, Placebo-Controlled, Flexible-Dosage Study to Evaluate the Efficacy and Safety of Adjunctive Quetiapine in the Treatment of Refractory Social Anxiety Disorder in Adults Completed NCT01224067 Phase 4 Quetiapine
14 Coordinated Anxiety Learning and Management (CALM): Improving Primary Care Anxiety Outcomes Completed NCT00347269 Phase 4 Psychotropic medication optimization
15 The Use of Acamprosate in Individuals With Alcohol Dependence and Comorbid Anxiety or Depression Completed NCT00330174 Phase 4 Acamprosate
16 A Randomised, Triple Blind, Placebo-controlled Trial Comparing the Effects of Cognitive Therapy, Paroxetine and Both Cognitive Therapy and Paroxetine in the Treatment of Patients With Primary Social Phobia Completed NCT00184106 Phase 4 Seroxat, Cognitive therapy, Seroxat+ cognitive therapy
17 Riluzole in Fragile X Syndrome: A Pilot Study Incorporating Biomarker Assay Completed NCT00895752 Phase 4 Riluzole
18 A Pilot Study to Treat Emotional Disorders in Primary Care With Evidence-based Psychological Techniques: A Randomized Controlled Trial Completed NCT01903096 Phase 4 Primary Care Treatment As Usual
19 A 14 Week, Randomized, Placebo-Controlled Cross-Over Study of Methylphenidate Hydrochloride Controlled Release Capsules in Adult ADHD With and Without Anxiety Disorder Comorbidity Recruiting NCT03785223 Phase 4 Methylphenidate Hydrochloride Controlled-Release Capsules;Placebo Capsule
20 Comparative Effectiveness of Mindfulness-Based Stress Reduction and Pharmacotherapy for Anxiety Recruiting NCT03522844 Phase 4 Escitalopram
21 Brief Intervention to Reduce Fear of Public Speaking Active, not recruiting NCT02790736 Phase 4 propranolol;Placebo
22 Sertraline in the Treatment of Generalized Social Phobia With Comorbidity Terminated NCT00182533 Phase 4 Sertraline;Placebo
23 A Controlled Study of the Efficacy of Botulinum Toxin A (Botox) for the Treatment of Social Anxiety Disorder (SAD) Terminated NCT03078270 Phase 4 botulinum toxin A
24 Transfer of Manualized Cognitive-Behavioral Therapy (CBT) for Social Phobia Into Clinical Practice (SophoPrax) Unknown status NCT01388231 Phase 2, Phase 3
25 Comparative Study of the Efficacy of a Cognitive-Behavioral Therapy for Post-Traumatic Stress Disorder With or Without D-Cycloserine Unknown status NCT00452231 Phase 2, Phase 3 D-cycloserine
26 Clinical Evaluation of BRL29060A (Paroxetine Hydrochloride Hydrate) in Social Phobia/Social Anxiety Disorder (SAD) -A Double-blind, Placebo-controlled Study- <Phase III Study> Completed NCT00318669 Phase 3 Paroxetine hydrochloride hydrate
27 Clinical Evaluation of BRL29060A (Paroxetine Hydrochloride Hydrate) in Social Phobia/Social Anxiety Disorder (SAD) -A Open-Label, Uncontrolled, Long-term Study- <Phase III Study> Completed NCT00264654 Phase 3 BRL29060A;paroxetine hydrochloride hydrate
28 Residential Cognitive Therapy Versus Residential Interpersonal Therapy for Social Phobia: A Randomized Controlled Trial Completed NCT00326430 Phase 2, Phase 3
29 A Randomized, Controlled Study of a Stepped-care Model for the Treatment of Social Phobia and Panic Disorder in Adults Completed NCT00619138 Phase 3
30 Treatment of Childhood Social Phobia Completed NCT00043537 Phase 3 Fluoxetine;Pill Placebo
31 A Comparison Between Internet-based Self-help Therapy and Group Therapy for Social Phobia - A Clinical Equivalence Trial Using Cognitive Behavioural Therapy (CBT) Completed NCT00564967 Phase 3
32 Placebo-Controlled Evaluation of the Efficacy of Yohimbine Hydrochloride for Enhancing the Effects of CBT for Social Phobia Completed NCT00958880 Phase 3 Yohimbine Hydrochloride;Sugar Pill
33 Placebo-Controlled Trial of Hypericum Perforatum in the Treatment of Generalized Social Anxiety Disorder (GSAD) Completed NCT00118833 Phase 2, Phase 3 Hypericum perforatum (St. John's wort)
34 Double Blind Placebo Controlled Parallel Group Comparison of Atomoxetine (Strattera) for Generalized Social Anxiety Disorder (GSAD) Completed NCT00260533 Phase 2, Phase 3 atomoxetine;placebo
35 A Single-center, Randomized, Double-blind, Phase III Comparison of the Efficacy and Safety of Quetiapine Fumarate (Oral Extended Release Tablets) to Placebo in Social Phobia Patients and Changes in Their Vasodilatory Response to Methyl-Nicotinate Completed NCT00773162 Phase 3 Seroquel;Sugar Pill
36 Research Unit on Pediatric Psychopharmacology Anxiety Treatment Study Completed NCT00000389 Phase 3 Fluvoxamine
37 D-cycloserine Enhancement of Exposure in Social Phobia Completed NCT00515879 Phase 3 D-cycloserine;Placebo
38 Duloxetine for Social Anxiety Disorder: Prediction of Long Term Outcome Completed NCT00114127 Phase 3 Duloxetine;Duloxetine;Placebo
39 A Double-Blind, Placebo-Controlled, Parallel-Group, Flexible-Dose Study of Venlafaxine ER In Children and Adolescent Outpatients With Social Anxiety Disorder Completed NCT00238719 Phase 3 Venlafaxine ER
40 2/3 Treatment of Anxiety in Autism Spectrum Disorder Completed NCT02028247 Phase 3
41 CBT Augmentation of Paroxetine for Social Anxiety Completed NCT00074802 Phase 3 Paroxetine
42 A Randomized, Double-Blind, Placebo-Controlled Pilot Study of Quetiapine in Social Anxiety Disorder Completed NCT00215254 Phase 2, Phase 3 quetiapine
43 A Feasibility Study for a Phase 3, Randomized, Four-Week, Double-Blind, Placebo-Controlled, Crossover Trial of the Efficacy and Safety of PH94B Nasal Spray in the Acute Treatment of Social Anxiety Disorder (SAD) Completed NCT02622958 Phase 3 PH94B
44 Utilizing Health Information Technology to Improve Health Care Quality: Implementation of a Computerized Cognitive Behavioral Therapy Protocol for Childhood Anxiety Completed NCT01416805 Phase 3
45 Child/Adolescent Anxiety Multimodal Treatment Study Completed NCT00052078 Phase 3 Sertraline (SRT);Placebo
46 A Systems Level Intervention for Unemployed Persons With Social Anxiety Completed NCT01654510 Phase 2, Phase 3
47 A 10 Week Open-Label Pilot Study to Evaluate the Effectiveness and Safety of Memantine(Namenda) as Augmentation Therapy in Patients With Generalized Anxiety Disorder (GAD) or Social Anxiety Disorder (SAD), Who Are Only Partial Responders to Selective Serotonin-Norepinephrine Reuptake Inhibitors (SNRI's) or Selective Serotonin Reuptake Inhibitors (SSRI's). Completed NCT00411398 Phase 3 Namenda/Memantine
48 Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01178385 Phase 2, Phase 3
49 A Randomized Controlled Trial of Multimodal Music Therapy for Children With Anxiety Disorders Completed NCT01062646 Phase 3
50 Double-Blind, Placebo-Controlled, Single-Dose Crossover Study Examining the Effects of Sublingual Riluzole (BHV-0223) on Public Speaking in Social Anxiety Disorder Active, not recruiting NCT03017508 Phase 2, Phase 3 BHV-0223;Placebo

Search NIH Clinical Center for Social Phobia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


gabapentin
gabapentin enacarbil
Paroxetine
Paroxetine Hydrochloride

Cochrane evidence based reviews: phobia, social

Sources

Genetic Tests for Social Phobia

About this section
Sources

Anatomical Context for Social Phobia

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MalaCards organs/tissues related to Social Phobia:

40
Brain, Testes, Amygdala, Cortex, Heart, Eye, Prefrontal Cortex
Sources

Publications for Social Phobia

About this section

Articles related to Social Phobia:

(show top 50) (show all 3757)
# Title Authors PMID Year
1
Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. 61 54
19582565 2009
2
Impact of prosocial neuropeptides on human brain function. 61 54
18655902 2008
3
Stimuli and consequences of dendritic release of oxytocin within the brain. 54 61
17956324 2007
4
The neuroscience of affiliation: forging links between basic and clinical research on neuropeptides and social behavior. 61 54
16884725 2006
5
Oxytocin modulates neural circuitry for social cognition and fear in humans. 61 54
16339042 2005
6
[Neurobiology and pharmacotherapy of social phobia]. 61 54
15538306 2004
7
Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia. 54 61
15158011 2004
8
Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with 11C McN 5652. 61 54
12457263 2002
9
A preliminary study of dopamine-mediated prolactin inhibition in generalised social phobia. 61 54
12140123 2002
10
Social phobia: diagnosis, severity and implications for treatment. 54 61
10361959 1999
11
Genetic linkage to the serotonin transporter protein and 5HT2A receptor genes excluded in generalized social phobia. 61 54
9925179 1998
12
Placebo-controlled trial of moclobemide in social phobia. 54 61
9534836 1998
13
Effects of the 5-HT3 antagonist, ondansetron, on the behavioral and physiological effects of pentagastrin in patients with panic disorder and social phobia. 61 54
9397424 1997
14
Social phobia: the clinical efficacy and tolerability of the monoamine oxidase -A and serotonin uptake inhibitor brofaromine. A double-blind placebo-controlled study. 54 61
8619339 1995
15
[3H]paroxetine binding to platelets of patients with social phobia: comparison to patients with panic disorder and healthy volunteers. 54 61
7711158 1995
16
Reversible monoamine oxidase-A inhibitors in social phobia. 54 61
8313403 1993
17
Efficacy of mobile app-based interactive cognitive behavioral therapy using a chatbot for panic disorder. 61
32446158 2020
18
Afraid of injustice? Justice sensitivity is linked to general anxiety and social phobia symptoms. 61
32553359 2020
19
Predicting the course of anxiety disorders: The role of biological parameters. 61
32179152 2020
20
Evaluation of a Novel Parent-Rated Scale for Selective Mutism. 61
30010386 2020
21
Predicting the naturalistic course in anxiety disorders using clinical and biological markers: a machine learning approach. 61
32524918 2020
22
[Innovative medical care concepts for adolescents with severe obesity]. 61
32518967 2020
23
Virtual Reality Therapy for Social Phobia: A Scoping Review. 61
32570476 2020
24
Psychiatric Co-morbidities and Body Shape Dissatisfaction in Adolescents with Obesity - A School Based Case Controlled Study. 61
32519259 2020
25
Sixth-year follow-up of the effects of recreational activities found to eliminate the symptoms of social phobia and shyness. 61
32475294 2020
26
Maladaptive Daydreaming Is Associated With Intensified Psychosocial Problems Experienced by Female Survivors of Childhood Sexual Abuse. 61
31053045 2020
27
Prospective Analysis and Comparison of Periareolar Excision (Delivery) Technique and Pull-Through Technique for the Treatment of Gynecomastia. 61
31989232 2020
28
Validity and reliability of social anxiety disorder diagnoses in the Swedish National Patient Register. 61
32414335 2020
29
Comparison of social anxiety between Japanese adults who stutter and non-stuttering controls. 61
32535211 2020
30
Classification of comorbidity in obsessive-compulsive disorder: A latent class analysis. 61
32403206 2020
31
Shorter and longer durations of sleep are associated with an increased twelve-month prevalence of psychiatric and substance use disorders: Findings from a nationally representative survey of US adults (NESARC-III). 61
32114030 2020
32
Validation of the AUDIT scale and factors associated with alcohol use disorder in adolescents: results of a National Lebanese Study. 61
32393212 2020
33
Mental Imagery in Social Anxiety in Children and Young People: A Systematic Review. 61
32297091 2020
34
Anxiety in Children with Selective Mutism: A Meta-analysis. 61
31650460 2020
35
Outpatient and self-referred participants: Adherence to treatment components and outcome in an internet intervention targeting anxiety disorders. 61
32346518 2020
36
Anxiety disorders comorbidity in pediatric bipolar disorder: a meta-analysis and meta-regression study. 61
31899546 2020
37
The Influence of Socio-Demographic Factors, Lifestyle and Psychiatric Indicators on Adherence to Treatment of Patients with Rheumatoid Arthritis: A Cross-Sectional Study. 61
32295226 2020
38
The Mental Health of Young Canadian Mothers. 61
32057608 2020
39
Evaluation of sexual functions in female rosacea patients: a prospective, case-control study. 61
32286521 2020
40
Comparing Scores From Full Length, Short Form, and Adaptive Tests of the Social Interaction Anxiety and Social Phobia Scales. 61
30873852 2020
41
Video games use in childhood and adolescence: Social phobia and differential susceptibility to media effects. 61
31674805 2020
42
Development of a Psychometric Measure of the Propensity to Consciously Control and Monitor Speech Production. 61
32310711 2020
43
Revisiting ADHD age-of-onset in adults: to what extent should we rely on the recall of childhood symptoms? 61
30968792 2020
44
Adolescent internalizing symptoms: The importance of multi-informant assessments in childhood. 61
32056947 2020
45
Construction and validation of the Lebanese fear of relationship commitment scale among a representative sample of the Lebanese population. 61
31353477 2020
46
Effects of a transdiagnostic cognitive behaviour therapy-based programme on the natural course of anxiety symptoms in adolescence. 61
32056776 2020
47
School-Based Treatment for Anxiety Research Study (STARS): a Randomized Controlled Effectiveness Trial. 61
31749064 2020
48
Prevalence, correlates and comorbidities of feeding and eating disorders in a nationally representative sample of Iranian children and adolescents. 61
31742760 2020
49
[Virtual reality exposure therapy for post-traumatic stress disorders, obsessive-compulsive disorders and anxiety disorders: Indications, added value and limitations]. 61
32151452 2020
50
Positive and negative valence systems in major depression have distinct clinical features, response to antidepressants, and relationships with immunomarkers. 61
32187776 2020
Sources

Variations for Social Phobia

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Sources

Expression for Social Phobia

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Search GEO for disease gene expression data for Social Phobia.
Sources

Pathways for Social Phobia

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Pathways related to Social Phobia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.76 TACR1 SLC6A4 MAOA HTR3A HTR1A
2
Serotonergic synapse 36
11.68 SLC6A4 MAOA HTR3A HTR1A
3
Neurotransmitter Clearance In The Synaptic Cleft 65
Show member pathways
 10.83 SLC6A4 MAOA COMT
4
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 60
10.7 SLC6A4 MAOA HTR3A HTR1A
5
noradrenaline and adrenaline degradation 1
Show member pathways
 10.61 MAOA COMT
6
Dopamine metabolism 1
10.51 MAOA COMT
7
Methylphenidate Pathway, Pharmacodynamics 60
Show member pathways
 10.38 SLC6A4 MAOA HTR1A DRD2 COMT
Sources

GO Terms for Social Phobia

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Cellular components related to Social Phobia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 9.63 WASF2 WASF1 SLC6A4 HTR3A HTR1A DRD2
2 SCAR complex GO:0031209 9.26 WASF2 WASF1
3 integral component of presynaptic membrane GO:0099056 9.13 SLC6A4 HTR3A DRD2
4 integral component of postsynaptic membrane GO:0099055 8.8 SLC6A4 HTR3A DRD2

Biological processes related to Social Phobia according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.19 TACR1 PTK7 PRL OXT HTR3A HTR1A
2 response to drug GO:0042493 9.89 SLC6A4 DRD2 COMT CAT
3 response to ethanol GO:0045471 9.78 HTR3A DRD2 CAT
4 response to estradiol GO:0032355 9.77 SLC6A4 OXT CAT
5 response to toxic substance GO:0009636 9.73 SLC6A4 DRD2 CAT
6 female pregnancy GO:0007565 9.7 PRL OXT COMT
7 memory GO:0007613 9.69 SLC6A4 OXT CCK
8 vasoconstriction GO:0042310 9.58 SLC6A4 HTR1A
9 dopamine metabolic process GO:0042417 9.57 DRD2 COMT
10 positive regulation of renal sodium excretion GO:0035815 9.55 OXT DRD2
11 grooming behavior GO:0007625 9.54 OXT DRD2
12 catecholamine metabolic process GO:0006584 9.49 MAOA COMT
13 positive regulation of Arp2/3 complex-mediated actin nucleation GO:2000601 9.48 WASF2 WASF1
14 neurotransmitter catabolic process GO:0042135 9.46 MAOA COMT
15 dopamine catabolic process GO:0042420 9.43 MAOA COMT
16 serotonin receptor signaling pathway GO:0007210 9.4 HTR3A HTR1A
17 drinking behavior GO:0042756 9.37 OXT DRD2
18 response to cocaine GO:0042220 9.33 OXT HTR3A DRD2
19 lamellipodium morphogenesis GO:0072673 9.32 WASF2 WASF1
20 sperm ejaculation GO:0042713 9.26 SLC6A4 OXT
21 response to inactivity GO:0014854 8.96 DRD2 CAT
22 regulation of sensory perception of pain GO:0051930 8.8 OXT COMT CCK

Molecular functions related to Social Phobia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Arp2/3 complex binding GO:0071933 8.96 WASF2 WASF1
2 serotonin binding GO:0051378 8.8 SLC6A4 HTR3A HTR1A
Sources

Sources for Social Phobia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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