Sodoku Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Sodoku Disease

MalaCards integrated aliases for Sodoku Disease:

Name: Sodoku Disease ¹² ¹⁵

Spirillosis ¹² ⁷¹ ³²

Spirillary Fever ¹²

Rat-Bite Fever ⁴⁴

Sodoku ⁷¹

Classifications:

MalaCards categories:
Global: Infectious diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Certain infectious and parasitic diseases

Certain zoonotic bacterial diseases

Rat-bite fevers

Spirillosis

External Ids:

Disease Ontology ¹² DOID:12096

ICD9CM ³⁴ 026.0

MeSH ⁴⁴ D011906

SNOMED-CT ⁶⁷ 19044004

ICD10 ³² A25.0

UMLS ⁷¹ C0152062 C0494042

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Summaries for Sodoku Disease

Disease Ontology : ¹² A primary bacterial infectious disease that results in infection, has material basis in Spirillum minus, which is transmitted by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted by bite of an infected animal, especially rat. The infection has symptom chills, has symptom relapsing fever, has symptom rash and has symptom joint pain.

MalaCards based summary : Sodoku Disease, also known as spirillosis, is related to rheumatoid arthritis and thrombocytopenia, and has symptoms including chills, rash and joint pain. An important gene associated with Sodoku Disease is CCL23 (C-C Motif Chemokine Ligand 23), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eye, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Sodoku Disease

Diseases related to Sodoku Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)

#	Related Disease	Score	Top Affiliating Genes
1	rheumatoid arthritis	29.1	OSM LIF IL11 HP CXCL6 CCL4
2	thrombocytopenia	29.1	THPO KITLG IL11 HP F7
3	haverhill fever	11.7
4	rat bite fever	11.1
5	exanthem	10.7
6	septic arthritis	10.6
7	endocarditis	10.5
8	osteomyelitis	10.3
9	arthritis	10.3
10	submucous uterine fibroid	10.3	LIF IL11
11	acquired thrombocytopenia	10.2	THPO IL11
12	purpura	10.2
13	qualitative platelet defect	10.2	THPO F7
14	cerebral meningioma	10.2	OSM LIF
15	crisponi/cold-induced sweating syndrome 2	10.2	OSM LIF IL11
16	serous labyrinthitis	10.1	CCL7 CCL11
17	plasmacytoma	10.1	OSM LIF IL11
18	disease by infectious agent	10.1
19	discitis	10.1
20	gastroenteritis	10.1
21	liver cirrhosis	10.1
22	gingivitis	10.1
23	arthrogryposis, distal, type 1a	10.1	OSM LIF CALB1
24	adhesive otitis media	10.1	F7 CCL11
25	splenic sequestration	10.0	THPO HP
26	blackwater fever	10.0	MB HP
27	spirillary rat-bite fever	10.0
28	rocky mountain spotted fever	10.0
29	limb ischemia	10.0
30	infective endocarditis	10.0
31	interstitial nephritis	10.0
32	spotted fever	10.0
33	disseminated intravascular coagulation	10.0
34	rabies	10.0
35	tetanus	10.0
36	pyelonephritis	10.0
37	hemopericardium	10.0
38	pericardial effusion	10.0
39	quadriplegia	10.0
40	alcoholic liver cirrhosis	10.0
41	alcohol use disorder	10.0
42	ventricular septal defect	10.0
43	heart septal defect	10.0
44	ischemia	10.0
45	arthropathy	10.0
46	reactive arthritis	10.0
47	myocarditis	10.0
48	lymphangitis	10.0
49	obstructive nephropathy	10.0	OSM LCN2 CLU
50	giant papillary conjunctivitis	10.0	IL11 CCL11

Graphical network of the top 20 diseases related to Sodoku Disease:

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Symptoms & Phenotypes for Sodoku Disease

Symptoms:

¹²

• chills
• rash

• joint pain
• relapsing fever

GenomeRNAi Phenotypes related to Sodoku Disease according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00106-A-0	9.55	XCL1
2	Decreased viability	GR00240-S-1	9.55	LIF
3	Decreased viability	GR00249-S	9.55	F7 HP LCN2 OSM
4	Decreased viability	GR00381-A-1	9.55	CXCL6 LIF
5	Decreased viability	GR00381-A-2	9.55	LIF
6	Decreased viability	GR00381-A-3	9.55	LIF
7	Decreased viability	GR00386-A-1	9.55	CCL22 KITLG MB THPO
8	Decreased viability	GR00402-S-2	9.55	IL11 LIF THPO

MGI Mouse Phenotypes related to Sodoku Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.7	CCL11 CCL19 CXCL13 CXCL6 HP KITLG
2	immune system	MP:0005387	9.4	CCL11 CCL19 CCL22 CLU CXCL13 CXCL6

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Drugs & Therapeutics for Sodoku Disease

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Preventing Cognitive and Functional Decline Among Seniors at Risk: A Community-Based Randomized Trial	Active, not recruiting	NCT03495037
2	Preventing Cognitive and Functional Decline Among Seniors at Risk-Effects of Online Training Aimed at Increasing Participation in Everyday Life During a Pandemic.	Active, not recruiting	NCT04439500

Search NIH Clinical Center for Sodoku Disease

Cochrane evidence based reviews: rat-bite fever

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Genetic Tests for Sodoku Disease

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Anatomical Context for Sodoku Disease

MalaCards organs/tissues related to Sodoku Disease:

⁴⁰

Eye

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Publications for Sodoku Disease

Articles related to Sodoku Disease:

(show all 12)

#	Title	Authors	PMID	Year
1	Gastric spirillosis in beagles. ⁶¹	Henry GA...Charbonneau DL	3592386	1987
2	[Clinical aspects of Sodoku disease]. ⁶¹	Gracheva NM...Rogova GM	4846977	1974
3	[Clinical, bacterioscopic and bacteriologic-histological studies on Gins' spirillosis]. ⁶¹	EICHNER K	13179623	1954
4	[Immobilysins against recurrent spirillosis (Borrelia duttonii)]. ⁶¹	LEVADITI C...HAMELIN A	12986374	1952
5	[Practical experience in the chemotherapy of contagious gingivitis (spirillosis) and of paradentitis]. ⁶¹	MULLER M	14884572	1951
6	[A few notes continuing the discussion on spirillosis]. ⁶¹	GINS HA	14813068	1951
7	[Investigation of spirillosis and its contagiousness]. ⁶¹	ANSPACH K...SAUERWEIN E	24541462	1951
8	[Critical observations on Gins' theory of contagious gingivitis (spirillosis)]. ⁶¹	HARNDT E	14793229	1950
9	[Spirillosis, pyococcosis, or putrescent infection?]. ⁶¹	GINS HA	15421182	1950
10	Experience with the diagnosis and therapy of spirillosis. ⁶¹	MEYER O	18103062	1948
11	The importance of spirillosis for the pathogenesis of paradental damage. ⁶¹	GINS HA	20259154	1947
12	Fowl Spirillosis. ⁶¹	Reaney MF	29005072	1907

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Genes for Sodoku Disease

Genes related to Sodoku Disease (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCL23	C-C Motif Chemokine Ligand 23	Protein Coding	4.66	DISEASES inferred ¹⁵
2	CXCL6	C-X-C Motif Chemokine Ligand 6	Protein Coding	4.44	DISEASES inferred ¹⁵
3	XCL1	X-C Motif Chemokine Ligand 1	Protein Coding	4.39	DISEASES inferred ¹⁵
4	OSM	Oncostatin M	Protein Coding	3.88	DISEASES inferred ¹⁵
5	CALB1	Calbindin 1	Protein Coding	3.87	DISEASES inferred ¹⁵
6	CCL19	C-C Motif Chemokine Ligand 19	Protein Coding	3.77	DISEASES inferred ¹⁵
7	CCL7	C-C Motif Chemokine Ligand 7	Protein Coding	3.75	DISEASES inferred ¹⁵
8	LIF	LIF Interleukin 6 Family Cytokine	Protein Coding	3.69	DISEASES inferred ¹⁵
9	CCL22	C-C Motif Chemokine Ligand 22	Protein Coding	3.65	DISEASES inferred ¹⁵
10	IL11	Interleukin 11	Protein Coding	3.59	DISEASES inferred ¹⁵
11	THPO	Thrombopoietin	Protein Coding	3.58	DISEASES inferred ¹⁵
12	F7	Coagulation Factor VII	Protein Coding	3.57	DISEASES inferred ¹⁵
13	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	3.56	DISEASES inferred ¹⁵
14	CLU	Clusterin	Protein Coding	3.5	DISEASES inferred ¹⁵
15	MB	Myoglobin	Protein Coding	3.4	DISEASES inferred ¹⁵
16	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	3.39	DISEASES inferred ¹⁵
17	LCN2	Lipocalin 2	Protein Coding	3.34	DISEASES inferred ¹⁵
18	KITLG	KIT Ligand	Protein Coding	3.3	DISEASES inferred ¹⁵
19	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	3.23	DISEASES inferred ¹⁵
20	HP	Haptoglobin	Protein Coding	3.23	DISEASES inferred ¹⁵

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Variations for Sodoku Disease

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Expression for Sodoku Disease

Search GEO for disease gene expression data for Sodoku Disease.

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Pathways for Sodoku Disease

Pathways related to Sodoku Disease according to GeneCards Suite gene sharing:

(show all 20)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.89	OSM LIF LCN2 KITLG IL11 HP
2	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.69	THPO OSM LIF KITLG IL11 CXCL6
3	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.52	XCL1 THPO OSM LIF IL11 CXCL6
4	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.4	THPO KITLG IL11 CCL7 CCL4 CCL23
5	Integrin Pathway ⁶³ Show member pathways FAK1 Signaling ⁶³ GnRH Signaling ⁶³ Inhibition of Angiogenesis by TSP1 ⁶³ Transendothelial Migration of Leukocytes ⁶³ UPA-UPAR Pathway ⁶³	13.29	XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
6	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.24	OSM LIF LCN2 KITLG IL11 CCL4
7	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.22	THPO OSM LIF KITLG IL11 CXCL6
8	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.04	THPO OSM LIF KITLG IL11 CXCL6
9	CCR5 Pathway in Macrophages ⁶³ Show member pathways Androgen Signaling ⁶³ Chemokine Signaling ⁶³ Chemokine signaling pathway ³⁶	12.73	XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
10	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.27	THPO OSM LIF IL11
11	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.18	LCN2 CXCL6 CCL7 CCL11
12	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.95	THPO LIF KITLG IL11
13	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	11.94	XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
14	Interleukin-4 and 13 signaling ⁶⁵	11.89	OSM LIF LCN2 CCL22 CCL11
15	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.82	THPO KITLG IL11
16	Hematopoietic cell lineage ³⁶	11.75	THPO KITLG IL11
17	Interleukin-6 family signaling ⁶⁵ Show member pathways IL-6-type cytokine receptor ligand interactions ⁶⁵ Interleukin-6 signaling ⁶⁵	11.48	OSM LIF IL11
18	Interleukin-10 signaling ⁶⁵	11.45	LIF CCL4 CCL22 CCL19
19	Immune response_Oncostatin M signaling via JAK-Stat in human cells ²³	10.87	OSM CCL11
20	G-protein signaling_Rap2B regulation pathway ²³	10.34	THPO OSM LIF KITLG IL11 CXCL6

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GO Terms for Sodoku Disease

Cellular components related to Sodoku Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.91	XCL1 THPO OSM LIF LCN2 KITLG
2	extracellular space	GO:0005615	9.58	XCL1 THPO OSM LIF LCN2 KITLG

Biological processes related to Sodoku Disease according to GeneCards Suite gene sharing:

(show all 33)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.33	XCL1 THPO KITLG IL11 CXCL6 CXCL13
2	G protein-coupled receptor signaling pathway	GO:0007186	10.24	XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
3	inflammatory response	GO:0006954	10.15	XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
4	immune response	GO:0006955	10.14	XCL1 OSM LIF CXCL6 CXCL13 CCL7
5	cytokine-mediated signaling pathway	GO:0019221	10.11	OSM LIF LCN2 IL11 CCL4 CCL22
6	positive regulation of GTPase activity	GO:0043547	10.1	XCL1 CCL7 CCL4 CCL23 CCL22 CCL19
7	cell-cell signaling	GO:0007267	10.08	XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
8	positive regulation of ERK1 and ERK2 cascade	GO:0070374	10.08	XCL1 THPO CCL7 CCL4 CCL23 CCL22
9	positive regulation of cell proliferation	GO:0008284	10.04	THPO OSM LIF KITLG IL11
10	cellular response to tumor necrosis factor	GO:0071356	10.03	XCL1 LCN2 CCL7 CCL4 CCL23 CCL22
11	response to virus	GO:0009615	10	XCL1 CLU CCL4 CCL22 CCL19 CCL11
12	cellular response to interferon-gamma	GO:0071346	10	XCL1 CCL7 CCL4 CCL23 CCL22 CCL19
13	positive regulation of protein kinase B signaling	GO:0051897	9.99	THPO OSM KITLG F7 CCL19
14	chemotaxis	GO:0006935	9.97	XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
15	defense response to bacterium	GO:0042742	9.94	LCN2 HP CXCL6 CXCL13
16	positive regulation of MAPK cascade	GO:0043410	9.92	THPO OSM LIF IL11
17	cellular calcium ion homeostasis	GO:0006874	9.92	CCL7 CCL23 CCL19 CCL11
18	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.91	OSM LIF KITLG IL11
19	cell chemotaxis	GO:0060326	9.91	CXCL6 CXCL13 CCL22 CCL19
20	monocyte chemotaxis	GO:0002548	9.91	XCL1 CCL7 CCL4 CCL23 CCL22 CCL19
21	cellular response to interleukin-1	GO:0071347	9.86	XCL1 LCN2 CCL7 CCL4 CCL23 CCL22
22	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.82	OSM LIF IL11
23	eosinophil chemotaxis	GO:0048245	9.77	CCL7 CCL4 CCL11
24	negative regulation of hormone secretion	GO:0046888	9.75	OSM LIF IL11
25	positive regulation of natural killer cell chemotaxis	GO:2000503	9.74	XCL1 CCL7 CCL4
26	lymphocyte chemotaxis	GO:0048247	9.7	XCL1 CCL7 CCL4 CCL23 CCL22 CCL19
27	positive regulation of receptor-mediated endocytosis	GO:0048260	9.66	CLU CCL19
28	positive regulation of T cell chemotaxis	GO:0010820	9.65	XCL1 CXCL13
29	positive regulation of leukocyte chemotaxis	GO:0002690	9.65	XCL1 F7
30	chronic inflammatory response	GO:0002544	9.63	CXCL13 CCL11
31	positive regulation of hematopoietic stem cell proliferation	GO:1902035	9.63	THPO KITLG
32	chemokine-mediated signaling pathway	GO:0070098	9.61	XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
33	neutrophil chemotaxis	GO:0030593	9.28	XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23

Molecular functions related to Sodoku Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.72	THPO OSM LIF KITLG IL11
2	heparin binding	GO:0008201	9.71	CXCL6 CXCL13 CCL7 CCL23
3	CCR chemokine receptor binding	GO:0048020	9.7	XCL1 CCL7 CCL4 CCL23 CCL22 CCL19
4	chemokine activity	GO:0008009	9.61	XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
5	cytokine activity	GO:0005125	9.47	XCL1 THPO OSM LIF KITLG IL11
6	CXCR chemokine receptor binding	GO:0045236	9.46	CXCL6 CXCL13
7	chemokine receptor binding	GO:0042379	9.43	XCL1 CCL19
8	CCR1 chemokine receptor binding	GO:0031726	9.43	CCL7 CCL4 CCL23
9	CCR10 chemokine receptor binding	GO:0031735	9.37	CXCL13 CCL19

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Sources for Sodoku Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

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¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia