Aliases & Classifications for Sodoku Disease

MalaCards integrated aliases for Sodoku Disease:

Name: Sodoku Disease 12 15
Spirillosis 12 71 32
Spirillary Fever 12
Rat-Bite Fever 44
Sodoku 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12096
ICD9CM 34 026.0
MeSH 44 D011906
SNOMED-CT 67 19044004
ICD10 32 A25.0
UMLS 71 C0152062 C0494042

Summaries for Sodoku Disease

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Spirillum minus, which is transmitted by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted by bite of an infected animal, especially rat. The infection has symptom chills, has symptom relapsing fever, has symptom rash and has symptom joint pain.

MalaCards based summary : Sodoku Disease, also known as spirillosis, is related to rheumatoid arthritis and thrombocytopenia, and has symptoms including chills, rash and joint pain. An important gene associated with Sodoku Disease is CCL23 (C-C Motif Chemokine Ligand 23), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eye, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Sodoku Disease

Diseases related to Sodoku Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.1 OSM LIF IL11 HP CXCL6 CCL4
2 thrombocytopenia 29.1 THPO KITLG IL11 HP F7
3 haverhill fever 11.7
4 rat bite fever 11.1
5 exanthem 10.7
6 septic arthritis 10.6
7 endocarditis 10.5
8 osteomyelitis 10.3
9 arthritis 10.3
10 submucous uterine fibroid 10.3 LIF IL11
11 acquired thrombocytopenia 10.2 THPO IL11
12 purpura 10.2
13 qualitative platelet defect 10.2 THPO F7
14 cerebral meningioma 10.2 OSM LIF
15 crisponi/cold-induced sweating syndrome 2 10.2 OSM LIF IL11
16 serous labyrinthitis 10.1 CCL7 CCL11
17 plasmacytoma 10.1 OSM LIF IL11
18 disease by infectious agent 10.1
19 discitis 10.1
20 gastroenteritis 10.1
21 liver cirrhosis 10.1
22 gingivitis 10.1
23 arthrogryposis, distal, type 1a 10.1 OSM LIF CALB1
24 adhesive otitis media 10.1 F7 CCL11
25 splenic sequestration 10.0 THPO HP
26 blackwater fever 10.0 MB HP
27 spirillary rat-bite fever 10.0
28 rocky mountain spotted fever 10.0
29 limb ischemia 10.0
30 infective endocarditis 10.0
31 interstitial nephritis 10.0
32 spotted fever 10.0
33 disseminated intravascular coagulation 10.0
34 rabies 10.0
35 tetanus 10.0
36 pyelonephritis 10.0
37 hemopericardium 10.0
38 pericardial effusion 10.0
39 quadriplegia 10.0
40 alcoholic liver cirrhosis 10.0
41 alcohol use disorder 10.0
42 ventricular septal defect 10.0
43 heart septal defect 10.0
44 ischemia 10.0
45 arthropathy 10.0
46 reactive arthritis 10.0
47 myocarditis 10.0
48 lymphangitis 10.0
49 obstructive nephropathy 10.0 OSM LCN2 CLU
50 giant papillary conjunctivitis 10.0 IL11 CCL11

Graphical network of the top 20 diseases related to Sodoku Disease:



Diseases related to Sodoku Disease

Symptoms & Phenotypes for Sodoku Disease

Symptoms:

12
  • chills
  • rash
  • joint pain
  • relapsing fever

GenomeRNAi Phenotypes related to Sodoku Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.55 XCL1
2 Decreased viability GR00240-S-1 9.55 LIF
3 Decreased viability GR00249-S 9.55 F7 HP LCN2 OSM
4 Decreased viability GR00381-A-1 9.55 CXCL6 LIF
5 Decreased viability GR00381-A-2 9.55 LIF
6 Decreased viability GR00381-A-3 9.55 LIF
7 Decreased viability GR00386-A-1 9.55 CCL22 KITLG MB THPO
8 Decreased viability GR00402-S-2 9.55 IL11 LIF THPO

MGI Mouse Phenotypes related to Sodoku Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCL11 CCL19 CXCL13 CXCL6 HP KITLG
2 immune system MP:0005387 9.4 CCL11 CCL19 CCL22 CLU CXCL13 CXCL6

Drugs & Therapeutics for Sodoku Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preventing Cognitive and Functional Decline Among Seniors at Risk: A Community-Based Randomized Trial Active, not recruiting NCT03495037
2 Preventing Cognitive and Functional Decline Among Seniors at Risk-Effects of Online Training Aimed at Increasing Participation in Everyday Life During a Pandemic. Active, not recruiting NCT04439500

Search NIH Clinical Center for Sodoku Disease

Cochrane evidence based reviews: rat-bite fever

Genetic Tests for Sodoku Disease

Anatomical Context for Sodoku Disease

MalaCards organs/tissues related to Sodoku Disease:

40
Eye

Publications for Sodoku Disease

Articles related to Sodoku Disease:

(show all 12)
# Title Authors PMID Year
1
Gastric spirillosis in beagles. 61
3592386 1987
2
[Clinical aspects of Sodoku disease]. 61
4846977 1974
3
[Clinical, bacterioscopic and bacteriologic-histological studies on Gins' spirillosis]. 61
13179623 1954
4
[Immobilysins against recurrent spirillosis (Borrelia duttonii)]. 61
12986374 1952
5
[Practical experience in the chemotherapy of contagious gingivitis (spirillosis) and of paradentitis]. 61
14884572 1951
6
[A few notes continuing the discussion on spirillosis]. 61
14813068 1951
7
[Investigation of spirillosis and its contagiousness]. 61
24541462 1951
8
[Critical observations on Gins' theory of contagious gingivitis (spirillosis)]. 61
14793229 1950
9
[Spirillosis, pyococcosis, or putrescent infection?]. 61
15421182 1950
10
Experience with the diagnosis and therapy of spirillosis. 61
18103062 1948
11
The importance of spirillosis for the pathogenesis of paradental damage. 61
20259154 1947
12
Fowl Spirillosis. 61
29005072 1907

Variations for Sodoku Disease

Expression for Sodoku Disease

Search GEO for disease gene expression data for Sodoku Disease.

Pathways for Sodoku Disease

Pathways related to Sodoku Disease according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 OSM LIF LCN2 KITLG IL11 HP
2
Show member pathways
13.69 THPO OSM LIF KITLG IL11 CXCL6
3
Show member pathways
13.52 XCL1 THPO OSM LIF IL11 CXCL6
4
Show member pathways
13.4 THPO KITLG IL11 CCL7 CCL4 CCL23
5
Show member pathways
13.29 XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
6
Show member pathways
13.24 OSM LIF LCN2 KITLG IL11 CCL4
7
Show member pathways
13.22 THPO OSM LIF KITLG IL11 CXCL6
8
Show member pathways
13.04 THPO OSM LIF KITLG IL11 CXCL6
9
Show member pathways
12.73 XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
10
Show member pathways
12.27 THPO OSM LIF IL11
11
Show member pathways
12.18 LCN2 CXCL6 CCL7 CCL11
12 11.95 THPO LIF KITLG IL11
13
Show member pathways
11.94 XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
14 11.89 OSM LIF LCN2 CCL22 CCL11
15 11.82 THPO KITLG IL11
16 11.75 THPO KITLG IL11
17
Show member pathways
11.48 OSM LIF IL11
18 11.45 LIF CCL4 CCL22 CCL19
19 10.87 OSM CCL11
20 10.34 THPO OSM LIF KITLG IL11 CXCL6

GO Terms for Sodoku Disease

Cellular components related to Sodoku Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 XCL1 THPO OSM LIF LCN2 KITLG
2 extracellular space GO:0005615 9.58 XCL1 THPO OSM LIF LCN2 KITLG

Biological processes related to Sodoku Disease according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.33 XCL1 THPO KITLG IL11 CXCL6 CXCL13
2 G protein-coupled receptor signaling pathway GO:0007186 10.24 XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
3 inflammatory response GO:0006954 10.15 XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
4 immune response GO:0006955 10.14 XCL1 OSM LIF CXCL6 CXCL13 CCL7
5 cytokine-mediated signaling pathway GO:0019221 10.11 OSM LIF LCN2 IL11 CCL4 CCL22
6 positive regulation of GTPase activity GO:0043547 10.1 XCL1 CCL7 CCL4 CCL23 CCL22 CCL19
7 cell-cell signaling GO:0007267 10.08 XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.08 XCL1 THPO CCL7 CCL4 CCL23 CCL22
9 positive regulation of cell proliferation GO:0008284 10.04 THPO OSM LIF KITLG IL11
10 cellular response to tumor necrosis factor GO:0071356 10.03 XCL1 LCN2 CCL7 CCL4 CCL23 CCL22
11 response to virus GO:0009615 10 XCL1 CLU CCL4 CCL22 CCL19 CCL11
12 cellular response to interferon-gamma GO:0071346 10 XCL1 CCL7 CCL4 CCL23 CCL22 CCL19
13 positive regulation of protein kinase B signaling GO:0051897 9.99 THPO OSM KITLG F7 CCL19
14 chemotaxis GO:0006935 9.97 XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
15 defense response to bacterium GO:0042742 9.94 LCN2 HP CXCL6 CXCL13
16 positive regulation of MAPK cascade GO:0043410 9.92 THPO OSM LIF IL11
17 cellular calcium ion homeostasis GO:0006874 9.92 CCL7 CCL23 CCL19 CCL11
18 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.91 OSM LIF KITLG IL11
19 cell chemotaxis GO:0060326 9.91 CXCL6 CXCL13 CCL22 CCL19
20 monocyte chemotaxis GO:0002548 9.91 XCL1 CCL7 CCL4 CCL23 CCL22 CCL19
21 cellular response to interleukin-1 GO:0071347 9.86 XCL1 LCN2 CCL7 CCL4 CCL23 CCL22
22 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.82 OSM LIF IL11
23 eosinophil chemotaxis GO:0048245 9.77 CCL7 CCL4 CCL11
24 negative regulation of hormone secretion GO:0046888 9.75 OSM LIF IL11
25 positive regulation of natural killer cell chemotaxis GO:2000503 9.74 XCL1 CCL7 CCL4
26 lymphocyte chemotaxis GO:0048247 9.7 XCL1 CCL7 CCL4 CCL23 CCL22 CCL19
27 positive regulation of receptor-mediated endocytosis GO:0048260 9.66 CLU CCL19
28 positive regulation of T cell chemotaxis GO:0010820 9.65 XCL1 CXCL13
29 positive regulation of leukocyte chemotaxis GO:0002690 9.65 XCL1 F7
30 chronic inflammatory response GO:0002544 9.63 CXCL13 CCL11
31 positive regulation of hematopoietic stem cell proliferation GO:1902035 9.63 THPO KITLG
32 chemokine-mediated signaling pathway GO:0070098 9.61 XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
33 neutrophil chemotaxis GO:0030593 9.28 XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23

Molecular functions related to Sodoku Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.72 THPO OSM LIF KITLG IL11
2 heparin binding GO:0008201 9.71 CXCL6 CXCL13 CCL7 CCL23
3 CCR chemokine receptor binding GO:0048020 9.7 XCL1 CCL7 CCL4 CCL23 CCL22 CCL19
4 chemokine activity GO:0008009 9.61 XCL1 CXCL6 CXCL13 CCL7 CCL4 CCL23
5 cytokine activity GO:0005125 9.47 XCL1 THPO OSM LIF KITLG IL11
6 CXCR chemokine receptor binding GO:0045236 9.46 CXCL6 CXCL13
7 chemokine receptor binding GO:0042379 9.43 XCL1 CCL19
8 CCR1 chemokine receptor binding GO:0031726 9.43 CCL7 CCL4 CCL23
9 CCR10 chemokine receptor binding GO:0031735 9.37 CXCL13 CCL19

Sources for Sodoku Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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