Aliases & Classifications for Sodoku Disease

Summaries for Sodoku Disease

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Spirillum minus, which is transmitted by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted by bite of an infected animal, especially rat. The infection has symptom chills, has symptom relapsing fever, has symptom rash and has symptom joint pain.

MalaCards based summary : Sodoku Disease, also known as spirillosis, is related to haverhill fever and exanthem, and has symptoms including chills, rash and joint pain. An important gene associated with Sodoku Disease is CCL23 (C-C Motif Chemokine Ligand 23), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include eye and skin, and related phenotypes are fever and vomiting

Wikipedia : 74 Sodoku (鼠毒) is a bacterial zoonotic disease. It is caused by the Gram-negative rod Spirillum minus (also... more...

Related Diseases for Sodoku Disease

Diseases related to Sodoku Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 haverhill fever 12.7
2 exanthem 10.7
3 septic arthritis 10.6
4 endocarditis 10.5
5 gingivitis 10.4
6 stachybotrys chartarum 10.3 LIF CCL7
7 osteomyelitis 10.3
8 arthritis 10.3
9 rat bite fever 10.2
10 submucous uterine fibroid 10.2 LIF IL11
11 cerebral meningioma 10.2 OSM LIF
12 rheumatoid arthritis 10.2
13 purpura 10.2
14 spirillary rat-bite fever 10.2
15 qualitative platelet defect 10.1 THPO F7
16 acquired thrombocytopenia 10.1 THPO IL11
17 discitis 10.1
18 liver cirrhosis 10.1
19 back pain 10.1
20 headache 10.1
21 pyomyositis 10.1 MB EPHX2
22 plasmacytoma 10.1 OSM LIF IL11
23 rocky mountain spotted fever 10.0
24 limb ischemia 10.0
25 infective endocarditis 10.0
26 interstitial nephritis 10.0
27 spotted fever 10.0
28 disseminated intravascular coagulation 10.0
29 rabies 10.0
30 tetanus 10.0
31 pyelonephritis 10.0
32 hemopericardium 10.0
33 pericardial effusion 10.0
34 quadriplegia 10.0
35 alcoholic liver cirrhosis 10.0
36 alcohol use disorder 10.0
37 thrombocytopenia 10.0
38 ventricular septal defect 10.0
39 heart septal defect 10.0
40 gastroenteritis 10.0
41 ischemia 10.0
42 arthropathy 10.0
43 reactive arthritis 10.0
44 chronic kidney disease 10.0
45 myocarditis 10.0
46 lymphangitis 10.0
47 serous labyrinthitis 9.9 CCL7 CCL11
48 arthrogryposis, distal, type 1a 9.9 OSM LIF CALB1
49 blood coagulation disease 9.9 THPO IL11 F7
50 blood platelet disease 9.9 THPO IL11 F7

Graphical network of the top 20 diseases related to Sodoku Disease:



Diseases related to Sodoku Disease

Symptoms & Phenotypes for Sodoku Disease

Human phenotypes related to Sodoku Disease:

31 (show all 29)
# Description HPO Frequency HPO Source Accession
1 fever 31 hallmark (90%) HP:0001945
2 vomiting 31 frequent (33%) HP:0002013
3 arthralgia 31 frequent (33%) HP:0002829
4 morbilliform rash 31 frequent (33%) HP:0012282
5 weight loss 31 occasional (7.5%) HP:0001824
6 myalgia 31 occasional (7.5%) HP:0003326
7 back pain 31 occasional (7.5%) HP:0003418
8 sepsis 31 occasional (7.5%) HP:0100806
9 headache 31 occasional (7.5%) HP:0002315
10 diarrhea 31 occasional (7.5%) HP:0002014
11 pustule 31 occasional (7.5%) HP:0200039
12 septic arthritis 31 occasional (7.5%) HP:0003095
13 erythema nodosum 31 occasional (7.5%) HP:0012219
14 maculopapular exanthema 31 occasional (7.5%) HP:0040186
15 scaling skin 31 occasional (7.5%) HP:0040189
16 lymphadenitis 31 occasional (7.5%) HP:0002840
17 diminished movement 31 occasional (7.5%) HP:0002374
18 pharyngitis 31 occasional (7.5%) HP:0025439
19 rigors 31 occasional (7.5%) HP:0025145
20 oligoarthritis 31 occasional (7.5%) HP:0040313
21 anemia 31 very rare (1%) HP:0001903
22 pericarditis 31 very rare (1%) HP:0001701
23 myocarditis 31 very rare (1%) HP:0012819
24 endocarditis 31 very rare (1%) HP:0100584
25 meningitis 31 very rare (1%) HP:0001287
26 pancreatitis 31 very rare (1%) HP:0001733
27 parotitis 31 very rare (1%) HP:0011850
28 abdominal aseptic abscess 31 very rare (1%) HP:0025181
29 tendonitis 31 very rare (1%) HP:0025230

Symptoms:

12
  • chills
  • rash
  • joint pain
  • relapsing fever

GenomeRNAi Phenotypes related to Sodoku Disease according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.6 XCL1
2 Decreased viability GR00221-A-2 9.6 EPHA5
3 Decreased viability GR00221-A-3 9.6 EPHA5
4 Decreased viability GR00221-A-4 9.6 EPHA5
5 Decreased viability GR00240-S-1 9.6 LIF
6 Decreased viability GR00249-S 9.6 F7 LCN2 OSM
7 Decreased viability GR00381-A-1 9.6 CXCL6 LIF
8 Decreased viability GR00381-A-2 9.6 LIF
9 Decreased viability GR00381-A-3 9.6 LIF
10 Decreased viability GR00386-A-1 9.6 CCL22 KITLG MB THPO
11 Decreased viability GR00402-S-2 9.6 IL11 LIF THPO

MGI Mouse Phenotypes related to Sodoku Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CCL11 CCL19 CXCL13 CXCL6 EPHA5 KITLG
2 immune system MP:0005387 9.4 CCL11 CCL19 CCL22 CLU CXCL13 CXCL6

Drugs & Therapeutics for Sodoku Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preventing Cognitive and Functional Decline Among Seniors at Risk: A Community-Based Randomized Trial Recruiting NCT03495037
2 Preventing Cognitive and Functional Decline Among Seniors at Risk-Effects of Online Training Aimed at Increasing Participation in Everyday Life During a Pandemic. Recruiting NCT04439500

Search NIH Clinical Center for Sodoku Disease

Cochrane evidence based reviews: rat-bite fever

Genetic Tests for Sodoku Disease

Anatomical Context for Sodoku Disease

MalaCards organs/tissues related to Sodoku Disease:

40
Eye, Skin

Publications for Sodoku Disease

Articles related to Sodoku Disease:

# Title Authors PMID Year
1
Gastric spirillosis in beagles. 61
3592386 1987
2
[Clinical aspects of Sodoku disease]. 61
4846977 1974
3
[Clinical, bacterioscopic and bacteriologic-histological studies on Gins' spirillosis]. 61
13179623 1954
4
[Immobilysins against recurrent spirillosis (Borrelia duttonii)]. 61
12986374 1952
5
[Practical experience in the chemotherapy of contagious gingivitis (spirillosis) and of paradentitis]. 61
14884572 1951
6
[Investigation of spirillosis and its contagiousness]. 61
24541462 1951
7
[A few notes continuing the discussion on spirillosis]. 61
14813068 1951
8
[Critical observations on Gins' theory of contagious gingivitis (spirillosis)]. 61
14793229 1950
9
[Spirillosis, pyococcosis, or putrescent infection?]. 61
15421182 1950
10
Fowl Spirillosis. 61
29005072 1907

Variations for Sodoku Disease

Expression for Sodoku Disease

Search GEO for disease gene expression data for Sodoku Disease.

Pathways for Sodoku Disease

Pathways related to Sodoku Disease according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 THPO OSM LIF KITLG IL11 EPHA5
2
Show member pathways
13.48 XCL1 THPO OSM LIF IL11 EPHA5
3
Show member pathways
13.37 THPO KITLG IL11 EPHA5 CCL7 CCL23
4
Show member pathways
13.25 XCL1 CXCL6 CXCL13 CCL7 CCL23 CCL22
5
Show member pathways
13.17 OSM LIF LCN2 KITLG IL11 CCL22
6
Show member pathways
13.1 THPO OSM LIF KITLG IL11 CXCL6
7
Show member pathways
12.92 THPO OSM LIF KITLG IL11 EPHA5
8
Show member pathways
12.76 XCL1 CXCL6 CXCL13 CCL7 CCL23 CCL22
9
Show member pathways
12.28 THPO OSM LIF IL11
10
Show member pathways
12.18 LCN2 CXCL6 CCL7 CCL11
11
Show member pathways
12.09 XCL1 CXCL6 CXCL13 CCL7 CCL23 CCL22
12 11.92 THPO LIF KITLG IL11
13 11.89 OSM LIF LCN2 CCL22 CCL11
14 11.81 THPO KITLG IL11
15 11.73 THPO KITLG IL11
16
Show member pathways
11.48 OSM LIF IL11
17 11.39 LIF CCL22 CCL19
18 10.85 OSM CCL11
19 10.34 THPO OSM LIF KITLG IL11 EPHA5

GO Terms for Sodoku Disease

Cellular components related to Sodoku Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 XCL1 THPO OSM LIF LCN2 KITLG
2 cell GO:0005623 9.76 XCL1 LCN2 CXCL13 CCL7 CCL23 CCL19
3 extracellular space GO:0005615 9.53 XCL1 THPO OSM LIF LCN2 KITLG

Biological processes related to Sodoku Disease according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.3 XCL1 THPO KITLG IL11 CXCL6 CXCL13
2 G protein-coupled receptor signaling pathway GO:0007186 10.21 XCL1 CXCL6 CXCL13 CCL7 CCL23 CCL22
3 inflammatory response GO:0006954 10.11 XCL1 CXCL6 CXCL13 CCL7 CCL23 CCL22
4 cytokine-mediated signaling pathway GO:0019221 10.07 OSM LIF LCN2 IL11 CCL22 CCL19
5 immune response GO:0006955 10.07 XCL1 OSM LIF CXCL6 CXCL13 CCL7
6 positive regulation of GTPase activity GO:0043547 10.05 XCL1 CCL7 CCL23 CCL22 CCL19 CCL11
7 positive regulation of cell proliferation GO:0008284 10.04 THPO OSM LIF KITLG IL11
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.04 XCL1 THPO CCL7 CCL23 CCL22 CCL19
9 cell-cell signaling GO:0007267 10.02 XCL1 CXCL6 CXCL13 CCL7 CCL23 CCL22
10 positive regulation of protein kinase B signaling GO:0051897 9.98 THPO OSM KITLG F7 CCL19
11 cellular response to tumor necrosis factor GO:0071356 9.98 XCL1 LCN2 CCL7 CCL23 CCL22 CCL19
12 response to virus GO:0009615 9.95 XCL1 LCN2 CLU CCL22 CCL19 CCL11
13 cellular response to interferon-gamma GO:0071346 9.93 XCL1 CCL7 CCL23 CCL22 CCL19 CCL11
14 positive regulation of MAPK cascade GO:0043410 9.92 THPO OSM LIF IL11
15 cellular calcium ion homeostasis GO:0006874 9.91 CCL7 CCL23 CCL19 CCL11
16 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.9 OSM LIF KITLG IL11
17 cell chemotaxis GO:0060326 9.89 CXCL6 CXCL13 CCL22 CCL19
18 monocyte chemotaxis GO:0002548 9.88 XCL1 CCL7 CCL23 CCL22 CCL19 CCL11
19 cellular response to interleukin-1 GO:0071347 9.87 XCL1 LCN2 CCL7 CCL23 CCL22 CCL19
20 chemotaxis GO:0006935 9.86 XCL1 CXCL6 CXCL13 CCL7 CCL23 CCL22
21 eosinophil chemotaxis GO:0048245 9.84 XCL1 CCL7 CCL23 CCL11
22 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.81 OSM LIF IL11
23 negative regulation of hormone secretion GO:0046888 9.74 OSM LIF IL11
24 positive regulation of receptor-mediated endocytosis GO:0048260 9.66 CLU CCL19
25 leukocyte chemotaxis GO:0030595 9.65 CXCL6 CXCL13
26 positive regulation of T cell chemotaxis GO:0010820 9.65 XCL1 CXCL13
27 positive regulation of leukocyte chemotaxis GO:0002690 9.65 XCL1 F7
28 chronic inflammatory response GO:0002544 9.63 CXCL13 CCL11
29 positive regulation of natural killer cell chemotaxis GO:2000503 9.63 XCL1 CCL7
30 lymphocyte chemotaxis GO:0048247 9.63 XCL1 CCL7 CCL23 CCL22 CCL19 CCL11
31 positive regulation of hematopoietic stem cell proliferation GO:1902035 9.62 THPO KITLG
32 neutrophil chemotaxis GO:0030593 9.56 XCL1 CXCL6 CXCL13 CCL7 CCL23 CCL22
33 chemokine-mediated signaling pathway GO:0070098 9.23 XCL1 CXCL6 CXCL13 CCL7 CCL23 CCL22

Molecular functions related to Sodoku Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.71 CXCL6 CXCL13 CCL7 CCL23
2 growth factor activity GO:0008083 9.65 THPO OSM LIF KITLG IL11
3 CCR chemokine receptor binding GO:0048020 9.63 XCL1 CCL7 CCL23 CCL22 CCL19 CCL11
4 chemokine activity GO:0008009 9.56 XCL1 CXCL6 CXCL13 CCL7 CCL23 CCL22
5 CXCR chemokine receptor binding GO:0045236 9.46 CXCL6 CXCL13
6 cytokine activity GO:0005125 9.44 XCL1 THPO OSM LIF KITLG IL11
7 chemokine receptor binding GO:0042379 9.43 XCL1 CCL19
8 CCR1 chemokine receptor binding GO:0031726 9.37 CCL7 CCL23
9 CCR10 chemokine receptor binding GO:0031735 9.32 CXCL13 CCL19

Sources for Sodoku Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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