MCID: SFT002
MIFTS: 31

Soft Palate Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Soft Palate Cancer

MalaCards integrated aliases for Soft Palate Cancer:

Name: Soft Palate Cancer 12 15
Malignant Tumor of the Soft Palate 12
Malignant Tumor of Soft Palate 12
Palate Cancer Soft Palate 71

Classifications:



External Ids:

Disease Ontology 12 DOID:8578
ICD9CM 34 145.3
NCIt 50 C3529
SNOMED-CT 67 94049001
ICD10 32 C05.1
UMLS 71 C0153376 C0747152

Summaries for Soft Palate Cancer

MalaCards based summary : Soft Palate Cancer, also known as malignant tumor of the soft palate, is related to chronic cervicitis and epilepsy, idiopathic generalized 3. An important gene associated with Soft Palate Cancer is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Soft Palate Cancer

Diseases related to Soft Palate Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 chronic cervicitis 10.3 GP6 CDKN2A
2 epilepsy, idiopathic generalized 3 10.2 E2F4 E2F1
3 nasal cavity lymphoma 10.2 CDKN2A BCL6
4 plasmablastic lymphoma 10.1 CDKN2A BCL6
5 primary cutaneous b-cell lymphoma 10.1 CDKN2A BCL6
6 uterus carcinoma in situ 10.1 GP6 CDKN2A
7 cervix uteri carcinoma in situ 10.1 GP6 CDKN2A
8 bowenoid papulosis 10.0 CDKN2A CCND1
9 esophagus verrucous carcinoma 10.0 CDKN2A CCND1
10 tonsil squamous cell carcinoma 10.0 CDKN2A CCND1
11 breast papillomatosis 10.0 CDKN2A CCND1
12 anus cancer 10.0 GP6 CDKN2A
13 refractory hematologic cancer 10.0 TNFRSF4 CD22
14 eye lymphoma 9.9 CD22 BCL6
15 lymphosarcoma 9.9 CD22 BCL6
16 ischemic fasciitis 9.9 CDKN2A CCND1
17 adult lymphoma 9.9 CD22 BCL6
18 bone squamous cell carcinoma 9.9 CDKN2A CCND1
19 oropharynx cancer 9.9 GP6 CDKN2A CCND1
20 composite lymphoma 9.9 CD22 BCL6
21 chondromyxoid fibroma 9.9 CDKN2A CCND1
22 nodular lymphocyte predominant hodgkin lymphoma 9.9 CCND1 BCL6
23 laryngeal benign neoplasm 9.9 CDKN2A CCND1
24 mutagen sensitivity 9.9 IGF1 CCND1
25 epiglottis neoplasm 9.8 CCND1 BCL6
26 nodular malignant melanoma 9.8 CDKN2A CCND1
27 reproductive organ benign neoplasm 9.8 IGF1 CDKN2A CCND1
28 gastrointestinal lymphoma 9.8 CCND1 BCL6
29 endometrial adenocarcinoma 9.8 IGF1 CDKN2A CCND1
30 colorectal adenoma 9.8 IGF1 CDKN2A CCND1
31 tracheal lymphoma 9.8 SOX11 CCND1 BCL6
32 gallbladder lymphoma 9.7 SOX11 CCND1 BCL6
33 cell type benign neoplasm 9.7 IGF1 CDKN2A CCND1
34 melanoma, cutaneous malignant 1 9.7 E2F1 CDKN2A CCND1
35 osteogenic sarcoma 9.7 IGF1 E2F5 E2F4 E2F1 CDKN2A
36 burkitt lymphoma 9.7 SOX11 E2F4 E2F1 CDKN2A BCL6
37 mantle cell lymphoma 9.6 SOX11 CDKN2A CCND1 BCL6
38 lynch syndrome 9.6 IGF1 E2F2 CDKN2A CCND1
39 alpha chain disease 9.5 CD22 CCND1 BCL6
40 spleen cancer 9.5 CD22 CCND1 BCL6
41 marginal zone b-cell lymphoma 9.5 CD22 CCND1 BCL6
42 mature b-cell neoplasm 9.5 CD22 CCND1 BCL6
43 lymphoma, mucosa-associated lymphoid type 9.5 CD22 CCND1 BCL6
44 myeloma, multiple 9.4 IGF1 CDKN2A CCND1 BCL6
45 cll/sll 9.4 SOX11 CD22 CCND1 BCL6
46 eye disease 9.4 IGF1 E2F4 E2F1 CDKN2A CCND1
47 b-cell lymphoma 9.4 CDKN2A CD22 CCND1 BCL6
48 familial retinoblastoma 9.3 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
49 retinoblastoma 9.0 E2F5 E2F4 E2F3 E2F2 E2F1 CDKN2A
50 retinal cancer 8.6 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3

Graphical network of the top 20 diseases related to Soft Palate Cancer:



Diseases related to Soft Palate Cancer

Symptoms & Phenotypes for Soft Palate Cancer

GenomeRNAi Phenotypes related to Soft Palate Cancer according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-102 10.03 IGF1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 10.03 IGF1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-122 10.03 ACLY
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-126 10.03 CCND1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 10.03 IGF1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 10.03 IGF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10.03 IGF1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 10.03 CCND1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-163 10.03 CCND1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10.03 ACLY
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 10.03 CCND1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 10.03 CCND1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-199 10.03 CCND1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 10.03 IGF1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-21 10.03 IGF1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 10.03 IGF1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.03 ACLY CCND1
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-25 10.03 CCND1
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 10.03 IGF1
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.03 CCND1
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 10.03 ACLY
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 10.03 IGF1
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 10.03 CCND1
24 Reduced mammosphere formation GR00396-S 9.1 BCL6 CCND1 CD22 E2F2 IGF1 TNFRSF4

MGI Mouse Phenotypes related to Soft Palate Cancer:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.41 BCL6 CCND1 CD22 CDKN2A E2F1 E2F2
2 growth/size/body region MP:0005378 10.31 BCL6 CCND1 CDKN2A E2F1 E2F2 E2F3
3 mortality/aging MP:0010768 10.3 ACLY BCL6 CCND1 CD22 CDKN2A E2F1
4 cardiovascular system MP:0005385 10.29 BCL6 CCND1 CDKN2A E2F1 E2F3 E2F4
5 hematopoietic system MP:0005397 10.26 BCL6 CCND1 CD22 CDKN2A E2F1 E2F2
6 endocrine/exocrine gland MP:0005379 10.25 BCL6 CCND1 CDKN2A E2F1 E2F2 E2F3
7 immune system MP:0005387 10.25 BCL6 CCND1 CD22 CDKN2A E2F1 E2F2
8 homeostasis/metabolism MP:0005376 10.23 ACLY BCL6 CCND1 CDKN2A E2F1 E2F3
9 integument MP:0010771 10.18 BCL6 CCND1 CDKN2A E2F1 E2F2 E2F3
10 digestive/alimentary MP:0005381 10.07 CCND1 CDKN2A E2F1 E2F3 E2F4 SOX11
11 normal MP:0002873 10.03 BCL6 CCND1 E2F1 E2F2 E2F3 E2F4
12 nervous system MP:0003631 10.02 CCND1 CD22 CDKN2A E2F1 E2F2 E2F3
13 reproductive system MP:0005389 9.9 BCL6 CCND1 CD22 CDKN2A E2F1 E2F3
14 respiratory system MP:0005388 9.73 BCL6 CCND1 CDKN2A E2F1 E2F2 E2F3
15 skeleton MP:0005390 9.32 CCND1 CDKN2A E2F1 E2F3 E2F4 E2F5

Drugs & Therapeutics for Soft Palate Cancer

Search Clinical Trials , NIH Clinical Center for Soft Palate Cancer

Genetic Tests for Soft Palate Cancer

Anatomical Context for Soft Palate Cancer

Publications for Soft Palate Cancer

Articles related to Soft Palate Cancer:

# Title Authors PMID Year
1
Gene mutations in the D-loop region of mitochondrial DNA in oral squamous cell carcinoma. 61
25625701 2015
2
Modified folding radial forearm flap in soft palate and tonsillar fossa reconstruction. 61
23524714 2013
3
Cardiac metastasis of head and neck squamous cell carcinoma. 61
22921451 2012
4
Advanced soft palate cancer: the clinical importance of the parapharyngeal space. 61
16025055 2005
5
[A patient showing increased T3 and T4 levels due to ALP-interfering substances and heterophilic antibody]. 61
8911078 1996
6
Interstitial and external radiotherapy in carcinoma of the soft palate and uvula. 61
3138213 1988
7
[Induced hypertension chemotherapy combined with radiotherapy in 44 advanced cancer patients]. 61
3747162 1986
8
[Surgical diathermy treatment of buccopharyngeal tumors]. 61
7137778 1982

Variations for Soft Palate Cancer

Expression for Soft Palate Cancer

Search GEO for disease gene expression data for Soft Palate Cancer.

Pathways for Soft Palate Cancer

Pathways related to Soft Palate Cancer according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 TNFRSF4 SOX11 IGF1 E2F5 E2F4 E2F3
2
Show member pathways
13.61 IGF1 E2F5 E2F4 E2F3 E2F2 E2F1
3
Show member pathways
13.34 E2F5 E2F4 E2F3 E2F2 E2F1 CDKN2A
4
Show member pathways
13.15 IGF1 E2F5 E2F4 E2F3 E2F2 E2F1
5
Show member pathways
12.88 E2F7 E2F4 E2F1 CDKN2A BCL6
6
Show member pathways
12.84 E2F3 E2F2 E2F1 CDKN2A CCND1
7
Show member pathways
12.83 IGF1 E2F3 E2F2 E2F1 CDKN2A CCND1
8
Show member pathways
12.81 E2F3 E2F2 E2F1 CDKN2A CCND1
9 12.79 IGF1 E2F3 E2F2 E2F1 CDKN2A CCND1
10
Show member pathways
12.71 IGF1 E2F3 E2F2 E2F1 CDKN2A CCND1
11
Show member pathways
12.67 IGF1 E2F5 E2F4 E2F3 E2F2 E2F1
12
Show member pathways
12.62 IGF1 E2F3 E2F2 E2F1 CDKN2A CCND1
13
Show member pathways
12.52 E2F6 E2F5 E2F4 E2F3 E2F2 E2F1
14 12.5 E2F3 E2F2 E2F1 CDKN2A CCND1
15
Show member pathways
12.44 E2F5 E2F4 E2F3 E2F2 E2F1
16
Show member pathways
12.33 E2F5 E2F4 E2F3 E2F2 E2F1 CDKN2A
17
Show member pathways
12.3 IGF1 E2F1 CDKN2A CCND1
18 12.29 E2F3 E2F2 E2F1 CDKN2A CCND1
19 12.28 E2F6 E2F5 E2F4 E2F3 E2F2 E2F1
20
Show member pathways
12.22 E2F5 E2F4 E2F3 E2F2 E2F1 CCND1
21
Show member pathways
12.17 E2F4 E2F1 CDKN2A CCND1
22
Show member pathways
12.15 E2F4 E2F2 E2F1 CCND1
23 12.11 E2F5 E2F4 E2F3 E2F2 E2F1 CDKN2A
24
Show member pathways
11.99 IGF1 CCND1 BCL6
25 11.98 E2F5 E2F4 CCND1
26 11.97 IGF1 E2F4 E2F1
27
Show member pathways
11.95 E2F3 E2F1 CCND1
28 11.92 E2F5 E2F1 CCND1
29 11.9 CDKN2A CCND1 BCL6
30 11.86 IGF1 E2F1 CDKN2A
31
Show member pathways
11.84 E2F7 E2F4 E2F1
32 11.84 E2F3 E2F2 E2F1 CCND1
33
Show member pathways
11.81 E2F5 E2F4 E2F3 E2F2 E2F1
34 11.8 E2F3 E2F2 E2F1 CCND1
35 11.72 E2F3 E2F2 E2F1 CDKN2A CCND1
36 11.66 E2F7 E2F6 E2F5 E2F4 E2F3 E2F2
37
Show member pathways
11.43 E2F6 E2F5 E2F4 E2F3 E2F2 E2F1
38 11.32 E2F3 E2F2 E2F1 CDKN2A
39 11.27 IGF1 E2F5 E2F4 E2F3 E2F2 E2F1
40 11.03 E2F1 CDKN2A
41 10.99 E2F5 E2F4 E2F3 E2F2 E2F1 CCND1

GO Terms for Soft Palate Cancer

Cellular components related to Soft Palate Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.1 SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
2 nucleoplasm GO:0005654 9.97 SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
3 chromatin GO:0000785 9.91 SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
4 transcription factor complex GO:0005667 9.56 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
5 RNA polymerase II transcription factor complex GO:0090575 9.23 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3

Biological processes related to Soft Palate Cancer according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.98 SOX11 IGF1 E2F3 E2F1 CDKN2A
2 regulation of transcription by RNA polymerase II GO:0006357 9.97 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.95 SOX11 E2F8 E2F7 E2F6 E2F1 CCND1
4 regulation of transcription, DNA-templated GO:0006355 9.91 SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
5 regulation of cell cycle GO:0051726 9.8 E2F5 E2F2 E2F1 CCND1
6 G1/S transition of mitotic cell cycle GO:0000082 9.67 E2F3 E2F1 CDKN2A CCND1
7 positive regulation of transcription by RNA polymerase II GO:0045944 9.65 SOX11 IGF1 E2F8 E2F7 E2F5 E2F4
8 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083 9.63 E2F6 E2F4 E2F1
9 negative regulation of cell-matrix adhesion GO:0001953 9.59 CDKN2A BCL6
10 regulation of G1/S transition of mitotic cell cycle GO:2000045 9.58 E2F1 CCND1
11 hepatocyte differentiation GO:0070365 9.57 E2F8 E2F7
12 trophoblast giant cell differentiation GO:0060707 9.56 E2F8 E2F7
13 negative regulation of cytokinesis GO:0032466 9.55 E2F8 E2F7
14 negative regulation of fat cell proliferation GO:0070345 9.54 E2F3 E2F1
15 lens fiber cell apoptotic process GO:1990086 9.52 E2F2 E2F1
16 chorionic trophoblast cell differentiation GO:0060718 9.51 E2F8 E2F7
17 negative regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071930 9.48 E2F7 E2F1
18 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.46 E2F8 E2F7 E2F4 E2F1
19 positive regulation of DNA endoreduplication GO:0032877 9.43 E2F8 E2F7
20 cell cycle GO:0007049 9.28 E2F8 E2F7 E2F6 E2F4 E2F3 E2F2

Molecular functions related to Soft Palate Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 10.11 SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 10.06 SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
3 sequence-specific double-stranded DNA binding GO:1990837 9.98 E2F8 E2F7 E2F4 E2F3 E2F2 E2F1
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.96 SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
5 transcription factor binding GO:0008134 9.93 E2F5 E2F4 E2F2 E2F1 CDKN2A CCND1
6 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.88 E2F7 E2F6 E2F3 E2F2 BCL6
7 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 9.81 E2F8 E2F7 E2F6 BCL6
8 protein dimerization activity GO:0046983 9.8 E2F6 E2F5 E2F4 E2F3 E2F2 E2F1
9 bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding GO:0001217 9.49 E2F8 E2F7
10 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding GO:0001216 9.46 E2F5 E2F4 E2F3 E2F1
11 proximal promoter sequence-specific DNA binding GO:0000987 9.43 SOX11 E2F8 E2F7 E2F3 E2F2 E2F1
12 DNA-binding transcription factor activity GO:0003700 9.32 SOX11 E2F8 E2F7 E2F6 E2F5 E2F4

Sources for Soft Palate Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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