Soft Palate Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SFT002 MIFTS: 31	Soft Palate Cancer Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases
Genes Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Soft Palate Cancer

MalaCards integrated aliases for Soft Palate Cancer:

Name: Soft Palate Cancer ¹² ¹⁵

Malignant Tumor of the Soft Palate ¹²

Malignant Tumor of Soft Palate ¹²

Palate Cancer Soft Palate ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Neoplasms

Malignant neoplasms of lip, oral cavity and pharynx

Malignant neoplasm of palate

Malignant neoplasm: Soft palate

External Ids:

Disease Ontology ¹² DOID:8578

ICD9CM ³⁴ 145.3

NCIt ⁵⁰ C3529

SNOMED-CT ⁶⁷ 94049001

ICD10 ³² C05.1

UMLS ⁷¹ C0153376 C0747152

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Summaries for Soft Palate Cancer

MalaCards based summary : Soft Palate Cancer, also known as malignant tumor of the soft palate, is related to chronic cervicitis and epilepsy, idiopathic generalized 3. An important gene associated with Soft Palate Cancer is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Soft Palate Cancer

Diseases related to Soft Palate Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)

#	Related Disease	Score	Top Affiliating Genes
1	chronic cervicitis	10.3	GP6 CDKN2A
2	epilepsy, idiopathic generalized 3	10.2	E2F4 E2F1
3	nasal cavity lymphoma	10.2	CDKN2A BCL6
4	plasmablastic lymphoma	10.1	CDKN2A BCL6
5	primary cutaneous b-cell lymphoma	10.1	CDKN2A BCL6
6	uterus carcinoma in situ	10.1	GP6 CDKN2A
7	cervix uteri carcinoma in situ	10.1	GP6 CDKN2A
8	bowenoid papulosis	10.0	CDKN2A CCND1
9	esophagus verrucous carcinoma	10.0	CDKN2A CCND1
10	tonsil squamous cell carcinoma	10.0	CDKN2A CCND1
11	breast papillomatosis	10.0	CDKN2A CCND1
12	anus cancer	10.0	GP6 CDKN2A
13	refractory hematologic cancer	10.0	TNFRSF4 CD22
14	eye lymphoma	9.9	CD22 BCL6
15	lymphosarcoma	9.9	CD22 BCL6
16	ischemic fasciitis	9.9	CDKN2A CCND1
17	adult lymphoma	9.9	CD22 BCL6
18	bone squamous cell carcinoma	9.9	CDKN2A CCND1
19	oropharynx cancer	9.9	GP6 CDKN2A CCND1
20	composite lymphoma	9.9	CD22 BCL6
21	chondromyxoid fibroma	9.9	CDKN2A CCND1
22	nodular lymphocyte predominant hodgkin lymphoma	9.9	CCND1 BCL6
23	laryngeal benign neoplasm	9.9	CDKN2A CCND1
24	mutagen sensitivity	9.9	IGF1 CCND1
25	epiglottis neoplasm	9.8	CCND1 BCL6
26	nodular malignant melanoma	9.8	CDKN2A CCND1
27	reproductive organ benign neoplasm	9.8	IGF1 CDKN2A CCND1
28	gastrointestinal lymphoma	9.8	CCND1 BCL6
29	endometrial adenocarcinoma	9.8	IGF1 CDKN2A CCND1
30	colorectal adenoma	9.8	IGF1 CDKN2A CCND1
31	tracheal lymphoma	9.8	SOX11 CCND1 BCL6
32	gallbladder lymphoma	9.7	SOX11 CCND1 BCL6
33	cell type benign neoplasm	9.7	IGF1 CDKN2A CCND1
34	melanoma, cutaneous malignant 1	9.7	E2F1 CDKN2A CCND1
35	osteogenic sarcoma	9.7	IGF1 E2F5 E2F4 E2F1 CDKN2A
36	burkitt lymphoma	9.7	SOX11 E2F4 E2F1 CDKN2A BCL6
37	mantle cell lymphoma	9.6	SOX11 CDKN2A CCND1 BCL6
38	lynch syndrome	9.6	IGF1 E2F2 CDKN2A CCND1
39	alpha chain disease	9.5	CD22 CCND1 BCL6
40	spleen cancer	9.5	CD22 CCND1 BCL6
41	marginal zone b-cell lymphoma	9.5	CD22 CCND1 BCL6
42	mature b-cell neoplasm	9.5	CD22 CCND1 BCL6
43	lymphoma, mucosa-associated lymphoid type	9.5	CD22 CCND1 BCL6
44	myeloma, multiple	9.4	IGF1 CDKN2A CCND1 BCL6
45	cll/sll	9.4	SOX11 CD22 CCND1 BCL6
46	eye disease	9.4	IGF1 E2F4 E2F1 CDKN2A CCND1
47	b-cell lymphoma	9.4	CDKN2A CD22 CCND1 BCL6
48	familial retinoblastoma	9.3	E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
49	retinoblastoma	9.0	E2F5 E2F4 E2F3 E2F2 E2F1 CDKN2A
50	retinal cancer	8.6	E2F8 E2F7 E2F6 E2F5 E2F4 E2F3

Graphical network of the top 20 diseases related to Soft Palate Cancer:

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Symptoms & Phenotypes for Soft Palate Cancer

GenomeRNAi Phenotypes related to Soft Palate Cancer according to GeneCards Suite gene sharing:

²⁶ (show all 24)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-102	10.03	IGF1
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-104	10.03	IGF1
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-122	10.03	ACLY
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-126	10.03	CCND1
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-134	10.03	IGF1
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-144	10.03	IGF1
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-153	10.03	IGF1
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-16	10.03	CCND1
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-163	10.03	CCND1
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-173	10.03	ACLY
11	Decreased shRNA abundance (Z-score < -2)	GR00366-A-177	10.03	CCND1
12	Decreased shRNA abundance (Z-score < -2)	GR00366-A-181	10.03	CCND1
13	Decreased shRNA abundance (Z-score < -2)	GR00366-A-199	10.03	CCND1
14	Decreased shRNA abundance (Z-score < -2)	GR00366-A-200	10.03	IGF1
15	Decreased shRNA abundance (Z-score < -2)	GR00366-A-21	10.03	IGF1
16	Decreased shRNA abundance (Z-score < -2)	GR00366-A-213	10.03	IGF1
17	Decreased shRNA abundance (Z-score < -2)	GR00366-A-216	10.03	ACLY CCND1
18	Decreased shRNA abundance (Z-score < -2)	GR00366-A-25	10.03	CCND1
19	Decreased shRNA abundance (Z-score < -2)	GR00366-A-34	10.03	IGF1
20	Decreased shRNA abundance (Z-score < -2)	GR00366-A-53	10.03	CCND1
21	Decreased shRNA abundance (Z-score < -2)	GR00366-A-73	10.03	ACLY
22	Decreased shRNA abundance (Z-score < -2)	GR00366-A-84	10.03	IGF1
23	Decreased shRNA abundance (Z-score < -2)	GR00366-A-95	10.03	CCND1
24	Reduced mammosphere formation	GR00396-S	9.1	BCL6 CCND1 CD22 E2F2 IGF1 TNFRSF4

MGI Mouse Phenotypes related to Soft Palate Cancer:

⁴⁶ (show all 15)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.41	BCL6 CCND1 CD22 CDKN2A E2F1 E2F2
2	growth/size/body region	MP:0005378	10.31	BCL6 CCND1 CDKN2A E2F1 E2F2 E2F3
3	mortality/aging	MP:0010768	10.3	ACLY BCL6 CCND1 CD22 CDKN2A E2F1
4	cardiovascular system	MP:0005385	10.29	BCL6 CCND1 CDKN2A E2F1 E2F3 E2F4
5	hematopoietic system	MP:0005397	10.26	BCL6 CCND1 CD22 CDKN2A E2F1 E2F2
6	endocrine/exocrine gland	MP:0005379	10.25	BCL6 CCND1 CDKN2A E2F1 E2F2 E2F3
7	immune system	MP:0005387	10.25	BCL6 CCND1 CD22 CDKN2A E2F1 E2F2
8	homeostasis/metabolism	MP:0005376	10.23	ACLY BCL6 CCND1 CDKN2A E2F1 E2F3
9	integument	MP:0010771	10.18	BCL6 CCND1 CDKN2A E2F1 E2F2 E2F3
10	digestive/alimentary	MP:0005381	10.07	CCND1 CDKN2A E2F1 E2F3 E2F4 SOX11
11	normal	MP:0002873	10.03	BCL6 CCND1 E2F1 E2F2 E2F3 E2F4
12	nervous system	MP:0003631	10.02	CCND1 CD22 CDKN2A E2F1 E2F2 E2F3
13	reproductive system	MP:0005389	9.9	BCL6 CCND1 CD22 CDKN2A E2F1 E2F3
14	respiratory system	MP:0005388	9.73	BCL6 CCND1 CDKN2A E2F1 E2F2 E2F3
15	skeleton	MP:0005390	9.32	CCND1 CDKN2A E2F1 E2F3 E2F4 E2F5

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Drugs & Therapeutics for Soft Palate Cancer

Search Clinical Trials , NIH Clinical Center for Soft Palate Cancer

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Genetic Tests for Soft Palate Cancer

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Anatomical Context for Soft Palate Cancer

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Publications for Soft Palate Cancer

Articles related to Soft Palate Cancer:

#	Title	Authors	PMID	Year
1	Gene mutations in the D-loop region of mitochondrial DNA in oral squamous cell carcinoma. ⁶¹	Yuan RT...Jia MY	25625701	2015
2	Modified folding radial forearm flap in soft palate and tonsillar fossa reconstruction. ⁶¹	Kang HG...Lee IJ	23524714	2013
3	Cardiac metastasis of head and neck squamous cell carcinoma. ⁶¹	Nagata S...Shinohara M	22921451	2012
4	Advanced soft palate cancer: the clinical importance of the parapharyngeal space. ⁶¹	Douglas WG...Hicks WL	16025055	2005
5	[A patient showing increased T3 and T4 levels due to ALP-interfering substances and heterophilic antibody]. ⁶¹	Kawakita S	8911078	1996
6	Interstitial and external radiotherapy in carcinoma of the soft palate and uvula. ⁶¹	Esche BA...Chassagne D	3138213	1988
7	[Induced hypertension chemotherapy combined with radiotherapy in 44 advanced cancer patients]. ⁶¹	Kitahara T...Sato H	3747162	1986
8	[Surgical diathermy treatment of buccopharyngeal tumors]. ⁶¹	Pinel J...Brami S	7137778	1982

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Genes for Soft Palate Cancer

Genes related to Soft Palate Cancer (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	4.88	DISEASES inferred ¹⁵
2	SOX11	SRY-Box Transcription Factor 11	Protein Coding	4.24	DISEASES inferred ¹⁵
3	E2F8	E2F Transcription Factor 8	Protein Coding	4.02	DISEASES inferred ¹⁵
4	GP6	Glycoprotein VI Platelet	Protein Coding	4	DISEASES inferred ¹⁵
5	E2F7	E2F Transcription Factor 7	Protein Coding	3.99	DISEASES inferred ¹⁵
6	E2F6	E2F Transcription Factor 6	Protein Coding	3.97	DISEASES inferred ¹⁵
7	ACLY	ATP Citrate Lyase	Protein Coding	3.95	DISEASES inferred ¹⁵
8	E2F5	E2F Transcription Factor 5	Protein Coding	3.92	DISEASES inferred ¹⁵
9	E2F2	E2F Transcription Factor 2	Protein Coding	3.8	DISEASES inferred ¹⁵
10	E2F4	E2F Transcription Factor 4	Protein Coding	3.79	DISEASES inferred ¹⁵
11	IGF1	Insulin Like Growth Factor 1	Protein Coding	3.71	DISEASES inferred ¹⁵
12	E2F1	E2F Transcription Factor 1	Protein Coding	3.68	DISEASES inferred ¹⁵
13	E2F3	E2F Transcription Factor 3	Protein Coding	3.66	DISEASES inferred ¹⁵
14	TNFRSF4	TNF Receptor Superfamily Member 4	Protein Coding	3.59	DISEASES inferred ¹⁵
15	CD22	CD22 Molecule	Protein Coding	3.51	DISEASES inferred ¹⁵
16	CCND1	Cyclin D1	Protein Coding	3.23	DISEASES inferred ¹⁵
17	BCL6	BCL6 Transcription Repressor	Protein Coding	3.22	DISEASES inferred ¹⁵

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Variations for Soft Palate Cancer

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Expression for Soft Palate Cancer

Search GEO for disease gene expression data for Soft Palate Cancer.

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Pathways for Soft Palate Cancer

Pathways related to Soft Palate Cancer according to GeneCards Suite gene sharing:

(show all 41)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.75	TNFRSF4 SOX11 IGF1 E2F5 E2F4 E2F3
2	GPCR Pathway ⁶³ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶³ Estrogen Pathway ⁶³ NFAT in Immune Response ⁶³ P2Y Receptor Signaling ⁶³ Pancreatic Adenocarcinoma ⁶³ Paxillin Interactions ⁶³ Ras Pathway ⁶³	13.61	IGF1 E2F5 E2F4 E2F3 E2F2 E2F1
3	Cell Cycle, Mitotic ⁶⁵ Show member pathways Cell Cycle ⁶⁵ M Phase ⁶⁵	13.34	E2F5 E2F4 E2F3 E2F2 E2F1 CDKN2A
4	IL-2 Pathway ⁶³ Show member pathways ErbB Family Pathway ⁶³ ErbB2-ErbB3 Heterodimers ⁶³ ErbB4 Pathway ⁶³ Growth Hormone Signaling ⁶³ HMGB1 Pathway ⁶³ IL-4 Pathway ⁶³ LPS Stimulated MAPK Signaling ⁶³ PACAP Signaling ⁶³ PI3K Signaling in B-Lymphocyte ⁶³ Prolactin Signaling ⁶³ Thrombopoietin Pathway ⁶³ TREM1 Pathway ⁶³ UVC-Induced MAPK Signaling ⁶³	13.15	IGF1 E2F5 E2F4 E2F3 E2F2 E2F1
5	Regulation of TP53 Activity ⁶⁵ Show member pathways Regulation of TP53 Activity through Association with Co-factors ⁶⁵ Regulation of TP53 Activity through Methylation ⁶⁵ Regulation of TP53 Activity through Phosphorylation ⁶⁵ Transcriptional Regulation by TP53 ⁶⁵	12.88	E2F7 E2F4 E2F1 CDKN2A BCL6
6	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.84	E2F3 E2F2 E2F1 CDKN2A CCND1
7	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	12.83	IGF1 E2F3 E2F2 E2F1 CDKN2A CCND1
8	Aldosterone synthesis and secretion ³⁶ Show member pathways Ca2+ activated K+ channels ⁶⁵ Cortisol synthesis and secretion ³⁶ Cushing syndrome ³⁶ Insulin secretion ³⁶ Melanogenesis ³⁶ Thyroid hormone synthesis ³⁶	12.81	E2F3 E2F2 E2F1 CDKN2A CCND1
9	Pathways in cancer ³⁶	12.79	IGF1 E2F3 E2F2 E2F1 CDKN2A CCND1
10	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.71	IGF1 E2F3 E2F2 E2F1 CDKN2A CCND1
11	Chks in Checkpoint Regulation ⁶³ Show member pathways DNA Repair Mechanisms ⁶³ Estrogen-mediated S-Phase Entry ⁶³ G2-M Phase Transition ⁶³ Parkinson's Disease Pathway ⁶³ SREBP Proteolysis ⁶³	12.67	IGF1 E2F5 E2F4 E2F3 E2F2 E2F1
12	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.62	IGF1 E2F3 E2F2 E2F1 CDKN2A CCND1
13	Mitotic G1-G1/S phases ⁶⁵ Show member pathways G1 to S cell cycle control ¹ G1/S Transition ⁶⁵	12.52	E2F6 E2F5 E2F4 E2F3 E2F2 E2F1
14	MicroRNAs in cancer ³⁶	12.5	E2F3 E2F2 E2F1 CDKN2A CCND1
15	Human Embryonic Stem Cell Pluripotency ⁶³ Show member pathways Factors Promoting Cardiogenesis in Vertebrates ⁶³	12.44	E2F5 E2F4 E2F3 E2F2 E2F1
16	Cyclins and Cell Cycle Regulation ⁶³ Show member pathways Cell Cycle Control by BTG Proteins ⁶³ Cyclin D associated events in G1 ⁶⁵ G1 Phase ⁶⁵ G1-S Phase Transition ⁶³ Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes ⁶⁵	12.33	E2F5 E2F4 E2F3 E2F2 E2F1 CDKN2A
17	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁶	12.3	IGF1 E2F1 CDKN2A CCND1
18	Human T-cell leukemia virus 1 infection ³⁶	12.29	E2F3 E2F2 E2F1 CDKN2A CCND1
19	Cell cycle ³⁶ ¹	12.28	E2F6 E2F5 E2F4 E2F3 E2F2 E2F1
20	p53 Signaling ⁶³ Show member pathways P53 Pathway ⁶⁶	12.22	E2F5 E2F4 E2F3 E2F2 E2F1 CCND1
21	Cell cycle Role of SCF complex in cell cycle regulation ²³ Show member pathways Cell cycle ESR1 regulation of G1/S transition ²³ Cell cycle Regulation of G1/S transition (part 1) ²³ Immune response MIF-JAB1 signaling ²³	12.17	E2F4 E2F1 CDKN2A CCND1
22	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁴ Show member pathways Akt Signaling Pathway ⁶⁴	12.15	E2F4 E2F2 E2F1 CCND1
23	Cellular senescence (KEGG) ³⁶	12.11	E2F5 E2F4 E2F3 E2F2 E2F1 CDKN2A
24	FoxO signaling pathway ³⁶ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	11.99	IGF1 CCND1 BCL6
25	TGF-beta Signaling Pathway (WikiPathways) ¹	11.98	E2F5 E2F4 CCND1
26	Adipogenesis ¹	11.97	IGF1 E2F4 E2F1
27	Pre-NOTCH Expression and Processing ⁶⁵ Show member pathways Defective LFNG causes SCDO3 ⁶⁵ Notch-HLH transcription pathway ⁶⁵ Post-transcriptional silencing by small RNAs ⁶⁵ Pre-NOTCH Processing in Golgi ⁶⁵ Pre-NOTCH Processing in the Endoplasmic Reticulum ⁶⁵ Pre-NOTCH Transcription and Translation ⁶⁵	11.95	E2F3 E2F1 CCND1
28	Spinal Cord Injury ¹	11.92	E2F5 E2F1 CCND1
29	DNA Damage Response (only ATM dependent) ¹	11.9	CDKN2A CCND1 BCL6
30	Senescence and Autophagy in Cancer ¹	11.86	IGF1 E2F1 CDKN2A
31	TP53 Regulates Transcription of Cell Cycle Genes ⁶⁵ Show member pathways TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain ⁶⁵ TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest ⁶⁵ TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest ⁶⁵	11.84	E2F7 E2F4 E2F1
32	Small cell lung cancer ³⁶	11.84	E2F3 E2F2 E2F1 CCND1
33	BRCA1 Pathway ⁶³ Show member pathways Fanconi's Anaemia Pathway ⁶³	11.81	E2F5 E2F4 E2F3 E2F2 E2F1
34	Retinoblastoma (RB) in Cancer ¹	11.8	E2F3 E2F2 E2F1 CCND1
35	Bladder cancer ³⁶ ¹	11.72	E2F3 E2F2 E2F1 CDKN2A CCND1
36	E2F transcription factor network ¹	11.66	E2F7 E2F6 E2F5 E2F4 E2F3 E2F2
37	Cell cycle Cell cycle (generic schema) ²³ Show member pathways Cell cycle Regulation of G1/S transition (part 2) ²³ G0 and Early G1 ⁶⁵ G2 Phase ⁶⁵	11.43	E2F6 E2F5 E2F4 E2F3 E2F2 E2F1
38	Oncogene Induced Senescence ⁶⁵	11.32	E2F3 E2F2 E2F1 CDKN2A
39	Glioblastoma Multiforme ⁶³	11.27	IGF1 E2F5 E2F4 E2F3 E2F2 E2F1
40	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶³	11.03	E2F1 CDKN2A
41	MNAR-PELP1 and Estrogen Receptor Interaction ⁶³	10.99	E2F5 E2F4 E2F3 E2F2 E2F1 CCND1

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GO Terms for Soft Palate Cancer

Cellular components related to Soft Palate Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	10.1	SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
2	nucleoplasm	GO:0005654	9.97	SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
3	chromatin	GO:0000785	9.91	SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
4	transcription factor complex	GO:0005667	9.56	E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
5	RNA polymerase II transcription factor complex	GO:0090575	9.23	E2F8 E2F7 E2F6 E2F5 E2F4 E2F3

Biological processes related to Soft Palate Cancer according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.98	SOX11 IGF1 E2F3 E2F1 CDKN2A
2	regulation of transcription by RNA polymerase II	GO:0006357	9.97	E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
3	negative regulation of transcription by RNA polymerase II	GO:0000122	9.95	SOX11 E2F8 E2F7 E2F6 E2F1 CCND1
4	regulation of transcription, DNA-templated	GO:0006355	9.91	SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
5	regulation of cell cycle	GO:0051726	9.8	E2F5 E2F2 E2F1 CCND1
6	G1/S transition of mitotic cell cycle	GO:0000082	9.67	E2F3 E2F1 CDKN2A CCND1
7	positive regulation of transcription by RNA polymerase II	GO:0045944	9.65	SOX11 IGF1 E2F8 E2F7 E2F5 E2F4
8	regulation of transcription involved in G1/S transition of mitotic cell cycle	GO:0000083	9.63	E2F6 E2F4 E2F1
9	negative regulation of cell-matrix adhesion	GO:0001953	9.59	CDKN2A BCL6
10	regulation of G1/S transition of mitotic cell cycle	GO:2000045	9.58	E2F1 CCND1
11	hepatocyte differentiation	GO:0070365	9.57	E2F8 E2F7
12	trophoblast giant cell differentiation	GO:0060707	9.56	E2F8 E2F7
13	negative regulation of cytokinesis	GO:0032466	9.55	E2F8 E2F7
14	negative regulation of fat cell proliferation	GO:0070345	9.54	E2F3 E2F1
15	lens fiber cell apoptotic process	GO:1990086	9.52	E2F2 E2F1
16	chorionic trophoblast cell differentiation	GO:0060718	9.51	E2F8 E2F7
17	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	GO:0071930	9.48	E2F7 E2F1
18	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977	9.46	E2F8 E2F7 E2F4 E2F1
19	positive regulation of DNA endoreduplication	GO:0032877	9.43	E2F8 E2F7
20	cell cycle	GO:0007049	9.28	E2F8 E2F7 E2F6 E2F4 E2F3 E2F2

Molecular functions related to Soft Palate Cancer according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA binding	GO:0003677	10.11	SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
2	DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	10.06	SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
3	sequence-specific double-stranded DNA binding	GO:1990837	9.98	E2F8 E2F7 E2F4 E2F3 E2F2 E2F1
4	RNA polymerase II proximal promoter sequence-specific DNA binding	GO:0000978	9.96	SOX11 E2F8 E2F7 E2F6 E2F5 E2F4
5	transcription factor binding	GO:0008134	9.93	E2F5 E2F4 E2F2 E2F1 CDKN2A CCND1
6	RNA polymerase II regulatory region sequence-specific DNA binding	GO:0000977	9.88	E2F7 E2F6 E2F3 E2F2 BCL6
7	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO:0001227	9.81	E2F8 E2F7 E2F6 BCL6
8	protein dimerization activity	GO:0046983	9.8	E2F6 E2F5 E2F4 E2F3 E2F2 E2F1
9	bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding	GO:0001217	9.49	E2F8 E2F7
10	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding	GO:0001216	9.46	E2F5 E2F4 E2F3 E2F1
11	proximal promoter sequence-specific DNA binding	GO:0000987	9.43	SOX11 E2F8 E2F7 E2F3 E2F2 E2F1
12	DNA-binding transcription factor activity	GO:0003700	9.32	SOX11 E2F8 E2F7 E2F6 E2F5 E2F4

Sources

Sources for Soft Palate Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia