MCID: SFT002
MIFTS: 33

Soft Palate Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Soft Palate Cancer

MalaCards integrated aliases for Soft Palate Cancer:

Name: Soft Palate Cancer 12 15
Malignant Tumor of the Soft Palate 12
Malignant Tumor of Soft Palate 12
Palate Cancer Soft Palate 71

Classifications:



External Ids:

Disease Ontology 12 DOID:8578
ICD9CM 34 145.3
NCIt 49 C3529
SNOMED-CT 67 94049001
ICD10 32 C05.1
UMLS 71 C0153376 C0747152

Summaries for Soft Palate Cancer

MalaCards based summary : Soft Palate Cancer, also known as malignant tumor of the soft palate, is related to chronic cervicitis and cervicitis. An important gene associated with Soft Palate Cancer is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Motexafin gadolinium and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include tonsil, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Soft Palate Cancer

Graphical network of the top 20 diseases related to Soft Palate Cancer:



Diseases related to Soft Palate Cancer

Symptoms & Phenotypes for Soft Palate Cancer

GenomeRNAi Phenotypes related to Soft Palate Cancer according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.74 E2F1 E2F3 IGF1 MTFMT
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.74 E2F1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.74 E2F3
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-130 9.74 E2F1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.74 IGF1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.74 E2F1 E2F3 IGF1 MTFMT
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.74 IGF1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.74 E2F3
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.74 IGF1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.74 E2F1 E2F3
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.74 E2F3
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-207 9.74 E2F1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.74 E2F1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.74 IGF1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.74 IGF1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.74 E2F1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.74 E2F3
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-64 9.74 MTFMT
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.74 IGF1

MGI Mouse Phenotypes related to Soft Palate Cancer:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.27 B2M CDKN2A E2F1 E2F2 E2F3 E2F4
2 growth/size/body region MP:0005378 10.17 B2M CDKN2A E2F1 E2F2 E2F3 E2F4
3 cardiovascular system MP:0005385 10.16 B2M CDKN2A E2F1 E2F3 E2F4 E2F5
4 mortality/aging MP:0010768 10.13 ACLY B2M CDKN2A E2F1 E2F2 E2F3
5 endocrine/exocrine gland MP:0005379 10.11 B2M CDKN2A E2F1 E2F2 E2F3 E2F4
6 immune system MP:0005387 10.11 B2M CDKN2A E2F1 E2F2 E2F3 E2F4
7 hematopoietic system MP:0005397 10.1 B2M CDKN2A E2F1 E2F2 E2F4 E2F6
8 embryo MP:0005380 10.02 B2M CDKN2A E2F1 E2F3 E2F4 E2F7
9 integument MP:0010771 10.02 B2M CDKN2A E2F1 E2F2 E2F3 E2F4
10 normal MP:0002873 9.81 E2F1 E2F2 E2F3 E2F4 E2F6 E2F7
11 reproductive system MP:0005389 9.61 B2M CDKN2A E2F1 E2F3 E2F4 E2F5
12 respiratory system MP:0005388 9.28 CDKN2A E2F1 E2F2 E2F3 E2F4 E2F7

Drugs & Therapeutics for Soft Palate Cancer

Drugs for Soft Palate Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Motexafin gadolinium Investigational Phase 1 156436-89-4, 246252-06-2 12047567
2 Dermatologic Agents Phase 1
3 Photosensitizing Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Trial Comparing Preservation of Function Status After Either Medpulser Electroporation With Intratumoral Bleomycin Therapy or Surgery in Patients With Locally Recurrent or Second Primary Squamous Cell Carcinoma of the Anterior Oral Cavity, Soft Palate, or Tonsil That Have Failed Primary Curative Therapy Withdrawn NCT00198315 Phase 3
2 Phase I Trial of Motexafin Gadolinium and Chemoradiation in Locally Advanced, Squamous Cell Carcinoma of the Head and Neck Terminated NCT00080028 Phase 1 Motexafin Gadolinium Injection

Search NIH Clinical Center for Soft Palate Cancer

Genetic Tests for Soft Palate Cancer

Anatomical Context for Soft Palate Cancer

MalaCards organs/tissues related to Soft Palate Cancer:

40
Tonsil

Publications for Soft Palate Cancer

Articles related to Soft Palate Cancer:

# Title Authors PMID Year
1
Gene mutations in the D-loop region of mitochondrial DNA in oral squamous cell carcinoma. 61
25625701 2015
2
Modified folding radial forearm flap in soft palate and tonsillar fossa reconstruction. 61
23524714 2013
3
Cardiac metastasis of head and neck squamous cell carcinoma. 61
22921451 2012
4
Advanced soft palate cancer: the clinical importance of the parapharyngeal space. 61
16025055 2005
5
[A patient showing increased T3 and T4 levels due to ALP-interfering substances and heterophilic antibody]. 61
8911078 1996
6
Interstitial and external radiotherapy in carcinoma of the soft palate and uvula. 61
3138213 1988
7
[Induced hypertension chemotherapy combined with radiotherapy in 44 advanced cancer patients]. 61
3747162 1986
8
[Surgical diathermy treatment of buccopharyngeal tumors]. 61
7137778 1982

Variations for Soft Palate Cancer

Expression for Soft Palate Cancer

Search GEO for disease gene expression data for Soft Palate Cancer.

Pathways for Soft Palate Cancer

Pathways related to Soft Palate Cancer according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 TNFRSF4 IGF1 E2F5 E2F4 E2F3 E2F2
2
Show member pathways
13.56 IGF1 E2F5 E2F4 E2F3 E2F2 E2F1
3
Show member pathways
13.29 E2F5 E2F4 E2F3 E2F2 E2F1 CDKN2A
4
Show member pathways
13.09 IGF1 E2F5 E2F4 E2F3 E2F2 E2F1
5
Show member pathways
12.8 E2F3 E2F2 E2F1 CDKN2A B2M
6
Show member pathways
12.73 IGF1 E2F3 E2F2 E2F1 CDKN2A
7 12.7 IGF1 E2F3 E2F2 E2F1 CDKN2A
8
Show member pathways
12.63 IGF1 E2F3 E2F2 E2F1 CDKN2A
9
Show member pathways
12.62 IGF1 E2F5 E2F4 E2F3 E2F2 E2F1
10
Show member pathways
12.55 IGF1 E2F3 E2F2 E2F1 CDKN2A
11
Show member pathways
12.47 E2F6 E2F5 E2F4 E2F3 E2F2 E2F1
12 12.41 E2F3 E2F2 E2F1 CDKN2A
13
Show member pathways
12.39 E2F5 E2F4 E2F3 E2F2 E2F1
14
Show member pathways
12.28 E2F5 E2F4 E2F3 E2F2 E2F1 CDKN2A
15 12.26 E2F3 E2F2 E2F1 CDKN2A B2M
16 12.23 E2F6 E2F5 E2F4 E2F3 E2F2 E2F1
17
Show member pathways
12.17 E2F5 E2F4 E2F3 E2F2 E2F1
18
Show member pathways
12.08 E2F4 E2F1 CDKN2A
19 12.05 E2F5 E2F4 E2F3 E2F2 E2F1 CDKN2A
20 11.93 IGF1 E2F4 E2F1
21 11.83 IGF1 E2F1 CDKN2A
22
Show member pathways
11.8 E2F7 E2F4 E2F1
23
Show member pathways
11.75 E2F5 E2F4 E2F3 E2F2 E2F1
24 11.74 E2F3 E2F2 E2F1
25 11.71 E2F3 E2F2 E2F1
26 11.67 E2F3 E2F2 E2F1 CDKN2A
27
Show member pathways
11.56 E2F6 E2F5 E2F4 E2F3 E2F2 E2F1
28 11.55 IGF1 E2F5 E2F4 E2F3 E2F2 E2F1
29 11.28 E2F3 E2F2 E2F1 CDKN2A
30 11.03 E2F7 E2F6 E2F5 E2F4 E2F3 E2F2
31 11.02 E2F5 E2F4 E2F3 E2F2 E2F1
32 10.98 E2F1 CDKN2A

GO Terms for Soft Palate Cancer

Cellular components related to Soft Palate Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.96 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
2 nuclear chromatin GO:0000790 9.76 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
3 transcription factor complex GO:0005667 9.56 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
4 RNA polymerase II transcription factor complex GO:0090575 9.23 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3

Biological processes related to Soft Palate Cancer according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 10.03 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.86 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
3 cell cycle GO:0007049 9.76 E2F8 E2F7 E2F6 E2F4 E2F3 E2F2
4 positive regulation of transcription by RNA polymerase II GO:0045944 9.65 IGF1 E2F8 E2F7 E2F6 E2F5 E2F4
5 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.62 E2F8 E2F7 E2F4 E2F1
6 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.58 E2F2 E2F1
7 positive regulation of cellular senescence GO:2000774 9.57 CDKN2A B2M
8 hepatocyte differentiation GO:0070365 9.56 E2F8 E2F7
9 trophoblast giant cell differentiation GO:0060707 9.55 E2F8 E2F7
10 amyloid fibril formation GO:1990000 9.54 CDKN2A B2M
11 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083 9.54 E2F6 E2F4 E2F1
12 negative regulation of cytokinesis GO:0032466 9.52 E2F8 E2F7
13 negative regulation of fat cell proliferation GO:0070345 9.51 E2F3 E2F1
14 chorionic trophoblast cell differentiation GO:0060718 9.49 E2F8 E2F7
15 lens fiber cell apoptotic process GO:1990086 9.48 E2F2 E2F1
16 negative regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071930 9.46 E2F7 E2F1
17 positive regulation of DNA endoreduplication GO:0032877 9.4 E2F8 E2F7
18 regulation of cell cycle GO:0051726 9.23 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3

Molecular functions related to Soft Palate Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.33 TNFRSF4 LAX1 IGF1 GP6 E2F8 E2F7
2 DNA binding GO:0003677 10.06 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
3 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.97 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
4 DNA-binding transcription factor activity GO:0003700 9.92 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
5 sequence-specific DNA binding GO:0043565 9.86 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3
6 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.78 E2F7 E2F6 E2F3 E2F2
7 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 9.73 E2F8 E2F7 E2F6 E2F1
8 protein dimerization activity GO:0046983 9.63 E2F6 E2F5 E2F4 E2F3 E2F2 E2F1
9 proximal promoter sequence-specific DNA binding GO:0000987 9.35 E2F8 E2F7 E2F3 E2F2 E2F1
10 transcription factor binding GO:0008134 9.28 E2F8 E2F7 E2F6 E2F5 E2F4 E2F3

Sources for Soft Palate Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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