MCID: SFT002
MIFTS: 23

Soft Palate Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Soft Palate Cancer

MalaCards integrated aliases for Soft Palate Cancer:

Name: Soft Palate Cancer 12 15
Malignant Tumor of the Soft Palate 12
Malignant Tumor of Soft Palate 12
Palate Cancer Soft Palate 71

Classifications:



External Ids:

Disease Ontology 12 DOID:8578
ICD9CM 34 145.3
NCIt 49 C3529
SNOMED-CT 67 363388009
ICD10 32 C05.1
UMLS 71 C0153376 C0747152

Summaries for Soft Palate Cancer

MalaCards based summary : Soft Palate Cancer, also known as malignant tumor of the soft palate, is related to nasal cavity lymphoma and cytomegalovirus infection. An important gene associated with Soft Palate Cancer is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways is Human T-cell leukemia virus 1 infection. The drugs Motexafin gadolinium and Photosensitizing Agents have been mentioned in the context of this disorder. Affiliated tissues include tonsil, and related phenotypes are digestive/alimentary and embryo

Related Diseases for Soft Palate Cancer

Diseases related to Soft Palate Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 nasal cavity lymphoma 9.8 CDKN2A B2M
2 cytomegalovirus infection 9.8 CDKN2A B2M
3 serous cystadenocarcinoma 9.7 CDKN2A B2M
4 plasmacytoma 9.7 CDKN2A B2M
5 ovarian serous cystadenocarcinoma 9.5 CDKN2A B2M
6 mantle cell lymphoma 9.2 SOX11 CDKN2A B2M

Graphical network of the top 20 diseases related to Soft Palate Cancer:



Diseases related to Soft Palate Cancer

Symptoms & Phenotypes for Soft Palate Cancer

MGI Mouse Phenotypes related to Soft Palate Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.62 B2M CDKN2A EDIL3 SOX11
2 embryo MP:0005380 9.56 B2M CDKN2A EDIL3 SOX11
3 endocrine/exocrine gland MP:0005379 9.46 B2M CDKN2A EDIL3 SOX11
4 integument MP:0010771 9.26 B2M CDKN2A EDIL3 SOX11
5 mortality/aging MP:0010768 9.02 B2M CDKN2A EDIL3 MTFMT SOX11

Drugs & Therapeutics for Soft Palate Cancer

Drugs for Soft Palate Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Motexafin gadolinium Investigational Phase 1 246252-06-2, 156436-89-4 12047567
2 Photosensitizing Agents Phase 1
3 Dermatologic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Trial Comparing Preservation of Function Status After Either Medpulser Electroporation With Intratumoral Bleomycin Therapy or Surgery in Patients With Locally Recurrent or Second Primary Squamous Cell Carcinoma of the Anterior Oral Cavity, Soft Palate, or Tonsil That Have Failed Primary Curative Therapy Withdrawn NCT00198315 Phase 3
2 Phase I Trial of Motexafin Gadolinium and Chemoradiation in Locally Advanced, Squamous Cell Carcinoma of the Head and Neck Terminated NCT00080028 Phase 1 Motexafin Gadolinium Injection

Search NIH Clinical Center for Soft Palate Cancer

Genetic Tests for Soft Palate Cancer

Anatomical Context for Soft Palate Cancer

MalaCards organs/tissues related to Soft Palate Cancer:

40
Tonsil

Publications for Soft Palate Cancer

Articles related to Soft Palate Cancer:

# Title Authors PMID Year
1
Gene mutations in the D-loop region of mitochondrial DNA in oral squamous cell carcinoma. 61
25625701 2015
2
Modified folding radial forearm flap in soft palate and tonsillar fossa reconstruction. 61
23524714 2013
3
Cardiac metastasis of head and neck squamous cell carcinoma. 61
22921451 2012
4
Advanced soft palate cancer: the clinical importance of the parapharyngeal space. 61
16025055 2005
5
[A patient showing increased T3 and T4 levels due to ALP-interfering substances and heterophilic antibody]. 61
8911078 1996
6
Interstitial and external radiotherapy in carcinoma of the soft palate and uvula. 61
3138213 1988
7
[Induced hypertension chemotherapy combined with radiotherapy in 44 advanced cancer patients]. 61
3747162 1986
8
[Surgical diathermy treatment of buccopharyngeal tumors]. 61
7137778 1982

Variations for Soft Palate Cancer

Expression for Soft Palate Cancer

Search GEO for disease gene expression data for Soft Palate Cancer.

Pathways for Soft Palate Cancer

Pathways related to Soft Palate Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 CDKN2A B2M

GO Terms for Soft Palate Cancer

Biological processes related to Soft Palate Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cellular senescence GO:2000774 8.96 CDKN2A B2M
2 amyloid fibril formation GO:1990000 8.62 CDKN2A B2M

Sources for Soft Palate Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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