MCID: SLR005
MIFTS: 29

Solar Urticaria

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Solar Urticaria

MalaCards integrated aliases for Solar Urticaria:

Name: Solar Urticaria 59 72 33

Characteristics:

Orphanet epidemiological data:

59
solar urticaria
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

ICD10 33 L56.3
ICD10 via Orphanet 34 L56.3
UMLS via Orphanet 73 C0263610
Orphanet 59 ORPHA97230
UMLS 72 C0263610

Summaries for Solar Urticaria

MalaCards based summary : Solar Urticaria is related to urticaria and rare photodermatosis. The drugs Omalizumab and Titanium dioxide have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and tongue, and related phenotypes are pruritus and vertigo

Wikipedia : 75 Solar urticaria (SU) is a rare condition in which exposure to ultraviolet or UV radiation, or sometimes... more...

Related Diseases for Solar Urticaria

Diseases related to Solar Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 urticaria 11.2
2 rare photodermatosis 10.4
3 protoporphyria, erythropoietic, 1 10.4
4 porphyria 10.3
5 ige responsiveness, atopic 10.3
6 physical urticaria 10.2
7 chronic actinic dermatitis 10.2
8 systemic lupus erythematosus 10.1
9 exanthem 10.1
10 rhinitis 10.1
11 hypereosinophilic syndrome 10.1
12 cold urticaria 10.1
13 autoimmune disease 10.0
14 photoparoxysmal response 1 10.0
15 fibrosis of extraocular muscles, congenital, 1 10.0
16 actinic prurigo 10.0
17 porphyria cutanea tarda 10.0
18 cystic fibrosis 10.0
19 dermatitis, atopic 10.0
20 dermatitis, atopic, 4 10.0
21 allergic rhinitis 10.0
22 dermatomyositis 10.0
23 allergic hypersensitivity disease 10.0
24 dermatitis 10.0
25 churg-strauss syndrome 10.0
26 purpura 10.0
27 skin disease 10.0
28 lupus erythematosus 10.0
29 48,xyyy 10.0
30 allergic angiitis 10.0
31 eosinophilic granulomatosis with polyangiitis 10.0
32 hydroa vacciniforme 10.0
33 syncope 10.0

Graphical network of the top 20 diseases related to Solar Urticaria:



Diseases related to Solar Urticaria

Symptoms & Phenotypes for Solar Urticaria

Human phenotypes related to Solar Urticaria:

59 32 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 59 32 hallmark (90%) Very frequent (99-80%) HP:0000989
2 vertigo 59 32 hallmark (90%) Very frequent (99-80%) HP:0002321
3 headache 59 32 hallmark (90%) Very frequent (99-80%) HP:0002315
4 periorbital edema 59 32 hallmark (90%) Very frequent (99-80%) HP:0100539
5 syncope 59 32 hallmark (90%) Very frequent (99-80%) HP:0001279
6 nausea 59 32 hallmark (90%) Very frequent (99-80%) HP:0002018
7 angioedema 59 32 hallmark (90%) Very frequent (99-80%) HP:0100665
8 wheezing 59 32 hallmark (90%) Very frequent (99-80%) HP:0030828
9 abnormal tongue morphology 59 32 hallmark (90%) Very frequent (99-80%) HP:0030809
10 abnormal lip morphology 32 hallmark (90%) HP:0000159
11 dyspnea 59 32 frequent (33%) Frequent (79-30%) HP:0002094
12 dermatographic urticaria 59 32 occasional (7.5%) Occasional (29-5%) HP:0011971
13 anaphylactic shock 59 32 very rare (1%) Very rare (<4-1%) HP:0100845
14 edema 59 Very frequent (99-80%)
15 urticaria 59 Very frequent (99-80%)
16 abnormality of the lip 59 Very frequent (99-80%)
17 immunologic hypersensitivity 59 Very frequent (99-80%)

Drugs & Therapeutics for Solar Urticaria

Drugs for Solar Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 2 242138-07-4
2
Titanium dioxide Approved Phase 2 13463-67-7
3
Afamelanotide Experimental, Investigational Phase 2 75921-69-6
4 Antibodies Phase 2
5 Immunologic Factors Phase 2
6 gamma-Globulins Phase 2
7 Immunoglobulins Phase 2
8 Immunoglobulins, Intravenous Phase 2
9 Rho(D) Immune Globulin Phase 2
10 Anti-Allergic Agents Phase 2
11 Respiratory System Agents Phase 2
12 Anti-Asthmatic Agents Phase 2
13 Radiation-Protective Agents Phase 2
14 Sunscreening Agents Phase 2
15 Protective Agents Phase 2
16 Dermatologic Agents Phase 2
17 Photosensitizing Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 2 Multicentric Study Evaluating the Efficacy of Polyvalent Intravenous Immunoglobulins in Idiopathic Severe and Refractory Solar Urticaria Completed NCT01360658 Phase 2 Intravenous immunoglobulins
2 Phase 2 Multicentric Study Evaluating the Efficacy of Omalizumab in Idiopathic Severe and Refractory Solar Urticaria Completed NCT02262130 Phase 2 Omalizumab
3 Evaluation of the Protection Activity of Microfine Ti02, Pigmentary Ti02 and Bisoctrizole and Their Combinations in Voluntary Patients With SU: Phase II Photoprovocation Test Completed NCT00483496 Phase 2 Titanium dioxide (Ti02) microfine 12.15% alone (formula RV3131A-MV1209);Ti02 pigmentary 3% alone (formula RV3131A-MV1211);bisoctrizole 10% alone (formula RV3131A-MV1237);Ti02 microfine 12.15% + Ti02 pigmentary 3% (formula RV3131A-MV1213);Ti02 microfine 12.15% + bisoctrizole 10% (formula RV3131A-MV1329);Ti02 pigmentary 3% + bisoctrizole 10% (formula RV3131A-MV1212);Ti02 microfine 12.15% + Ti02 pigmentary 3% + bisoctrizole 10% [V0096 CR (formula RV3131A-MV1166)];V0096 CR vehicle (formula RV3131A-MV1197)
4 A Phase II, Open Label Pilot Study to Evaluate the Safety and Efficacy of A Bioresorbable Subcutaneous Implant of CUV1647 in Patients With Solar Urticaria (SU) Completed NCT00859534 Phase 2 afamelanotide
5 The Effects of Visible Light on the Skin After Administration of Oral Polypodium Leucotomos Unknown status NCT02904798 Polypodium Leucotomos
6 Pathogenesis and Genetic Basis of Physical Induced Urticarial Syndromes Recruiting NCT00887939

Search NIH Clinical Center for Solar Urticaria

Genetic Tests for Solar Urticaria

Anatomical Context for Solar Urticaria

MalaCards organs/tissues related to Solar Urticaria:

41
Skin, Testes, Tongue

Publications for Solar Urticaria

Articles related to Solar Urticaria:

(show top 50) (show all 322)
# Title Authors PMID Year
1
Incapacitating solar urticaria: successful treatment with omalizumab. 38
31365663 2019
2
Real-life experience in the treatment of solar urticaria: retrospective cohort study. 38
30828851 2019
3
Successful treatment of solar urticaria with UVA1 hardening in three patients. 38
30576021 2019
4
Polymorphous light eruption with complication of solar urticaria revealed by phototesting. 38
30302798 2019
5
Solar urticaria - An Australian case series of 83 patients. 38
30585308 2019
6
Clinical response and long-term follow-up of 20 patients with refractory solar urticaria under treatment with omalizumab. 38
31150709 2019
7
Unexpected photosensitivity - a patient with dermatomyositis and concomitant solar urticaria. 38
30520178 2019
8
Evaluation of nine patients with solar urticaria during summer. 38
30924623 2019
9
Photocontact Dermatitis and Its Clinical Mimics: an Overview for the Allergist. 38
29951786 2019
10
Evaluating patient responses to omalizumab in solar urticaria. 38
30338865 2019
11
Solar Urticaria, a Disease with Many Dark Sides: Is Omalizumab the Right Therapeutic Response? Reflections from a Clinical Case Report. 38
31231681 2019
12
Induction of Light Tolerance Using Narrowband UV-B in Solar Urticaria. 38
30205902 2018
13
Effectiveness in the treatment of solar urticaria with omalizumab: Report of 7 cases. 38
29526307 2018
14
Inducing Light Tolerance With Narrowband UV-B Therapy in Solar Urticaria. 38
30314639 2018
15
Afamelanotide in the Treatment of Dermatologic Disease 38
30517779 2018
16
Erythropoietic protoporphyria and solar urticaria. 38
29683481 2018
17
How to Approach Chronic Inducible Urticaria. 38
30033913 2018
18
Omalizumab for the Treatment of Solar Urticaria: Case Series and Systematic Review of the Literature. 38
29572192 2018
19
Solar urticaria in 145 patients: Assessment of action spectra and impact on quality of life in adults and children. 38
29533487 2018
20
Paediatric solar urticaria: a case series. 38
29315482 2018
21
Herbal sun protection agents: Human studies. 38
29908579 2018
22
Clinical and photobiological response in eight patients with solar urticaria under treatment with omalizumab, and review of the literature. 38
29171925 2018
23
Solar urticaria developing in patients with erythropoietic protoporphyria: a clue to the pathogenesis of solar urticaria? 38
28796891 2018
24
Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence. 38
28751232 2018
25
Long-term management of chronic spontaneous urticaria with omalizumab. 38
28649751 2017
26
Response to Omalizumab in Solar Urticaria: Report of 3 Cases. 38
28457471 2017
27
Solar urticaria with an augmentation spectrum in a child. 38
28543282 2017
28
Pharmacokinetics and Pharmacodynamics of Afamelanotide and its Clinical Use in Treating Dermatologic Disorders. 38
28063031 2017
29
[Solar urticaria. Case report and literature review]. 38
29046033 2017
30
Refractory solar urticaria successfully treated with omalizumab with normalization of phototest. 38
28168968 2017
31
[Partial response of solar urticaria to omalizumab therapy]. 38
27995273 2017
32
Solar urticaria with a wide action spectrum from UVB to visible light complicated with UVA-induced polymorphous light eruption. 38
28160768 2017
33
Solar urticaria: Epidemiology and clinical phenotypes in a Spanish series of 224 patients. 38
27793344 2017
34
Solar urticaria induced by visible light: successful treatment with omalizumab. 38
27766671 2016
35
Clinical and etiologic evaluation of the children with chronic urticaria. 38
27931300 2016
36
[SOLAR URTICARIA]. 38
28530058 2016
37
Heat urticaria: a revision of published cases with an update on classification and management. 38
26973062 2016
38
Visible light-induced solar urticaria is improved by omalizumab. 38
27622987 2016
39
A case of atorvastatin-induced solar urticaria. 38
27499245 2016
40
Successful treatment of solar urticaria with omalizumab. 38
27607042 2016
41
Infrared radiation increases skin damage induced by other wavelengths in solar urticaria. 38
27622861 2016
42
Wedelolactone mitigates UVB induced oxidative stress, inflammation and early tumor promotion events in murine skin: plausible role of NFkB pathway. 38
27164422 2016
43
Analysis of solar urticaria in Thai patients. 38
27007836 2016
44
Unique coexistence of cold and solar urticaria and its efficient treatment. 38
26678859 2016
45
Three cases of solar urticaria successfully treated with omalizumab. 38
25640906 2016
46
Effectiveness of omalizumab in severe solar urticaria. 38
26803538 2016
47
Omalizumab in patients with severe and refractory solar urticaria: A phase II multicentric study. 38
26892659 2016
48
Failure of omalizumab in the treatment of solar urticaria. 38
25546321 2016
49
Solar urticaria. 38
26612794 2015
50
Treatment of solar urticaria using antihistamine and leukotriene receptor antagonist combinations tailored to disease severity. 38
26052871 2015

Variations for Solar Urticaria

Expression for Solar Urticaria

Search GEO for disease gene expression data for Solar Urticaria.

Pathways for Solar Urticaria

GO Terms for Solar Urticaria

Sources for Solar Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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