MCID: SLR005
MIFTS: 30

Solar Urticaria

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Solar Urticaria

MalaCards integrated aliases for Solar Urticaria:

Name: Solar Urticaria 58 71 32

Characteristics:

Orphanet epidemiological data:

58
solar urticaria
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare skin diseases


Summaries for Solar Urticaria

MalaCards based summary : Solar Urticaria is related to urticaria and rare photodermatosis. The drugs Omalizumab and Titanium dioxide have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and tongue, and related phenotypes are pruritus and vertigo

Wikipedia : 74 Solar urticaria (SU) is a rare condition in which exposure to ultraviolet or UV radiation, or sometimes... more...

Related Diseases for Solar Urticaria

Diseases related to Solar Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 urticaria 11.2
2 rare photodermatosis 10.4
3 protoporphyria, erythropoietic, 1 10.4
4 porphyria 10.3
5 ige responsiveness, atopic 10.3
6 physical urticaria 10.2
7 chronic actinic dermatitis 10.2
8 systemic lupus erythematosus 10.1
9 exanthem 10.1
10 rhinitis 10.1
11 hypereosinophilic syndrome 10.1
12 cold urticaria 10.1
13 autoimmune disease 10.0
14 photoparoxysmal response 1 10.0
15 fibrosis of extraocular muscles, congenital, 1 10.0
16 actinic prurigo 10.0
17 porphyria cutanea tarda 10.0
18 cystic fibrosis 10.0
19 dermatitis, atopic 10.0
20 dermatitis, atopic, 4 10.0
21 allergic rhinitis 10.0
22 dermatomyositis 10.0
23 allergic hypersensitivity disease 10.0
24 dermatitis 10.0
25 churg-strauss syndrome 10.0
26 purpura 10.0
27 skin disease 10.0
28 lupus erythematosus 10.0
29 48,xyyy 10.0
30 allergic angiitis 10.0
31 hydroa vacciniforme 10.0
32 syncope 10.0

Graphical network of the top 20 diseases related to Solar Urticaria:



Diseases related to Solar Urticaria

Symptoms & Phenotypes for Solar Urticaria

Human phenotypes related to Solar Urticaria:

58 31 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 58 31 hallmark (90%) Very frequent (99-80%) HP:0000989
2 vertigo 58 31 hallmark (90%) Very frequent (99-80%) HP:0002321
3 periorbital edema 58 31 hallmark (90%) Very frequent (99-80%) HP:0100539
4 headache 58 31 hallmark (90%) Very frequent (99-80%) HP:0002315
5 syncope 58 31 hallmark (90%) Very frequent (99-80%) HP:0001279
6 angioedema 58 31 hallmark (90%) Very frequent (99-80%) HP:0100665
7 nausea 58 31 hallmark (90%) Very frequent (99-80%) HP:0002018
8 abnormal tongue morphology 58 31 hallmark (90%) Very frequent (99-80%) HP:0030809
9 wheezing 58 31 hallmark (90%) Very frequent (99-80%) HP:0030828
10 abnormal lip morphology 31 hallmark (90%) HP:0000159
11 dyspnea 58 31 frequent (33%) Frequent (79-30%) HP:0002094
12 dermatographic urticaria 58 31 occasional (7.5%) Occasional (29-5%) HP:0011971
13 anaphylactic shock 58 31 very rare (1%) Very rare (<4-1%) HP:0100845
14 edema 58 Very frequent (99-80%)
15 urticaria 58 Very frequent (99-80%)
16 abnormality of the lip 58 Very frequent (99-80%)
17 immunologic hypersensitivity 58 Very frequent (99-80%)

Drugs & Therapeutics for Solar Urticaria

Drugs for Solar Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 2 242138-07-4
2
Titanium dioxide Approved Phase 2 13463-67-7
3
Afamelanotide Approved, Investigational Phase 2 75921-69-6
4 Antibodies Phase 2
5 Rho(D) Immune Globulin Phase 2
6 Immunoglobulins, Intravenous Phase 2
7 gamma-Globulins Phase 2
8 Immunologic Factors Phase 2
9 Immunoglobulins Phase 2
10 Respiratory System Agents Phase 2
11 Anti-Allergic Agents Phase 2
12 Anti-Asthmatic Agents Phase 2
13 Photosensitizing Agents Phase 2
14 Dermatologic Agents Phase 2
15 Protective Agents Phase 2
16 Sunscreening Agents Phase 2
17 Radiation-Protective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 2 Multicentric Study Evaluating the Efficacy of Polyvalent Intravenous Immunoglobulins in Idiopathic Severe and Refractory Solar Urticaria Completed NCT01360658 Phase 2 Intravenous immunoglobulins
2 Phase 2 Multicentric Study Evaluating the Efficacy of Omalizumab in Idiopathic Severe and Refractory Solar Urticaria Completed NCT02262130 Phase 2 Omalizumab
3 Evaluation of the Protection Activity of Microfine Ti02, Pigmentary Ti02 and Bisoctrizole and Their Combinations in Voluntary Patients With SU: Phase II Photoprovocation Test Completed NCT00483496 Phase 2 Titanium dioxide (Ti02) microfine 12.15% alone (formula RV3131A-MV1209);Ti02 pigmentary 3% alone (formula RV3131A-MV1211);bisoctrizole 10% alone (formula RV3131A-MV1237);Ti02 microfine 12.15% + Ti02 pigmentary 3% (formula RV3131A-MV1213);Ti02 microfine 12.15% + bisoctrizole 10% (formula RV3131A-MV1329);Ti02 pigmentary 3% + bisoctrizole 10% (formula RV3131A-MV1212);Ti02 microfine 12.15% + Ti02 pigmentary 3% + bisoctrizole 10% [V0096 CR (formula RV3131A-MV1166)];V0096 CR vehicle (formula RV3131A-MV1197)
4 A Phase II, Open Label Pilot Study to Evaluate the Safety and Efficacy of A Bioresorbable Subcutaneous Implant of CUV1647 in Patients With Solar Urticaria (SU) Completed NCT00859534 Phase 2 afamelanotide
5 The Effects of Visible Light on the Skin After Administration of Oral Polypodium Leucotomos Unknown status NCT02904798 Polypodium Leucotomos
6 Pathogenesis and Genetic Basis of Physical Induced Urticarial Syndromes Recruiting NCT00887939

Search NIH Clinical Center for Solar Urticaria

Genetic Tests for Solar Urticaria

Anatomical Context for Solar Urticaria

MalaCards organs/tissues related to Solar Urticaria:

40
Skin, Testes, Tongue

Publications for Solar Urticaria

Articles related to Solar Urticaria:

(show top 50) (show all 332)
# Title Authors PMID Year
1
Comparison of racial distribution of photodermatoses in USA academic dermatology clinics: A multicenter retrospective analysis of 1080 patients over a 10-year period. 61
32104953 2020
2
Good things come to those who wait: Successful response of solar urticaria to omalizumab after 1 year of treatment. 61
32430974 2020
3
[Medicaments and oral healthcare. Hyperpigmentation of oral soft tissues due to afamelanotide]. 61
32459219 2020
4
A qualitative study of knowledge, behaviour and attitudes regarding vitamin D acquisition among patients with photosensitivity disorders. 61
32274870 2020
5
Transient Pruritic Erythema as a Forme Fruste of Solar Urticaria. 61
32286025 2020
6
Characteristics and clinical significance of augmentation spectra in solar urticaria. 61
31960491 2020
7
Establishment of the basophil activation test to detect photoallergens in solar urticaria. 61
32348909 2020
8
Solar urticaria caused by visible light in a 33-year-old male refractory to treatment with omalizumab. 61
32141097 2020
9
Phototherapy in the Evaluation and Management of Photodermatoses. 61
31753194 2020
10
Real-life experience in the treatment of solar urticaria: retrospective cohort study. 61
30828851 2019
11
Incapacitating solar urticaria: successful treatment with omalizumab. 61
31365663 2019
12
Solar urticaria treated with omalizumab. 61
31487346 2019
13
Successful treatment of solar urticaria with UVA1 hardening in three patients. 61
30576021 2019
14
Polymorphous light eruption with complication of solar urticaria revealed by phototesting. 61
30302798 2019
15
Solar urticaria - An Australian case series of 83 patients. 61
30585308 2019
16
Clinical response and long-term follow-up of 20 patients with refractory solar urticaria under treatment with omalizumab. 61
31150709 2019
17
Unexpected photosensitivity - a patient with dermatomyositis and concomitant solar urticaria. 61
30520178 2019
18
Evaluation of nine patients with solar urticaria during summer. 61
30924623 2019
19
Photocontact Dermatitis and Its Clinical Mimics: an Overview for the Allergist. 61
29951786 2019
20
Evaluating patient responses to omalizumab in solar urticaria. 61
30338865 2019
21
Solar Urticaria, a Disease with Many Dark Sides: Is Omalizumab the Right Therapeutic Response? Reflections from a Clinical Case Report. 61
31231681 2019
22
Induction of Light Tolerance Using Narrowband UV-B in Solar Urticaria. 61
30205902 2018
23
Effectiveness in the treatment of solar urticaria with omalizumab: Report of 7 cases. 61
29526307 2018
24
Inducing Light Tolerance With Narrowband UV-B Therapy in Solar Urticaria. 61
30314639 2018
25
Afamelanotide in the Treatment of Dermatologic Disease 61
30517779 2018
26
Erythropoietic protoporphyria and solar urticaria. 61
29683481 2018
27
How to Approach Chronic Inducible Urticaria. 61
30033913 2018
28
Omalizumab for the Treatment of Solar Urticaria: Case Series and Systematic Review of the Literature. 61
29572192 2018
29
Solar urticaria in 145 patients: Assessment of action spectra and impact on quality of life in adults and children. 61
29533487 2018
30
Paediatric solar urticaria: a case series. 61
29315482 2018
31
Herbal sun protection agents: Human studies. 61
29908579 2018
32
Clinical and photobiological response in eight patients with solar urticaria under treatment with omalizumab, and review of the literature. 61
29171925 2018
33
Solar urticaria developing in patients with erythropoietic protoporphyria: a clue to the pathogenesis of solar urticaria? 61
28796891 2018
34
Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence. 61
28751232 2018
35
Long-term management of chronic spontaneous urticaria with omalizumab. 61
28649751 2017
36
Response to Omalizumab in Solar Urticaria: Report of 3 Cases. 61
28457471 2017
37
Solar urticaria with an augmentation spectrum in a child. 61
28543282 2017
38
Pharmacokinetics and Pharmacodynamics of Afamelanotide and its Clinical Use in Treating Dermatologic Disorders. 61
28063031 2017
39
[Solar urticaria. Case report and literature review]. 61
29046033 2017
40
Refractory solar urticaria successfully treated with omalizumab with normalization of phototest. 61
28168968 2017
41
[Partial response of solar urticaria to omalizumab therapy]. 61
27995273 2017
42
Solar urticaria with a wide action spectrum from UVB to visible light complicated with UVA-induced polymorphous light eruption. 61
28160768 2017
43
Solar urticaria: Epidemiology and clinical phenotypes in a Spanish series of 224 patients. 61
27793344 2017
44
Solar urticaria induced by visible light: successful treatment with omalizumab. 61
27766671 2016
45
Clinical and etiologic evaluation of the children with chronic urticaria. 61
27931300 2016
46
[SOLAR URTICARIA]. 61
28530058 2016
47
Heat urticaria: a revision of published cases with an update on classification and management. 61
26973062 2016
48
A case of atorvastatin-induced solar urticaria. 61
27499245 2016
49
Visible light-induced solar urticaria is improved by omalizumab. 61
27622987 2016
50
Successful treatment of solar urticaria with omalizumab. 61
27607042 2016

Variations for Solar Urticaria

Expression for Solar Urticaria

Search GEO for disease gene expression data for Solar Urticaria.

Pathways for Solar Urticaria

GO Terms for Solar Urticaria

Sources for Solar Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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