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MCID: SLT009
MIFTS: 39

Solitary Bone Cyst

Categories: Bone diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Solitary Bone Cyst

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MalaCards integrated aliases for Solitary Bone Cyst:

Name: Solitary Bone Cyst 58 37 32
Unicameral Bone Cyst 58
Bone Cysts 71

Characteristics:

Orphanet epidemiological data:

58
solitary bone cyst
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare bone diseases


External Ids:

ICD10 32 M85.4
ICD10 via Orphanet 33 M85.4
UMLS via Orphanet 72 C0005937
Orphanet 58 ORPHA83468
UMLS 71 C0005937
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Summaries for Solitary Bone Cyst

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MalaCards based summary : Solitary Bone Cyst, also known as unicameral bone cyst, is related to aneurysmal bone cysts and osteitis fibrosa. An important gene associated with Solitary Bone Cyst is TREM2 (Triggering Receptor Expressed On Myeloid Cells 2), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and NF-kappaB Signaling. The drugs Hormones and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone marrow and spinal cord, and related phenotypes are unicameral bone cyst and bone pain

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Related Diseases for Solitary Bone Cyst

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Diseases related to Solitary Bone Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 aneurysmal bone cysts 10.4
2 osteitis fibrosa 10.2
3 bone inflammation disease 10.2
4 coxa vara 10.1
5 ewing sarcoma 10.1
6 sarcoma 10.1
7 benign giant cell tumor 10.1
8 hypertrichosis 10.1
9 spindle cell sarcoma 10.1
10 bone giant cell tumor 10.1
11 overgrowth syndrome 10.1
12 fibrous dysplasia 10.1
13 lipomatosis, multiple 9.9
14 myositis 9.9
15 chondrosarcoma 9.9
16 osteogenic sarcoma 9.9
17 fibroma 9.9
18 osteoblastoma 9.9
19 pleomorphic lipoma 9.9
20 breast fibroadenoma 9.9
21 ossifying fibroma 9.9
22 exostosis 9.9
23 chondroma 9.9
24 myositis ossificans 9.9
25 florid cemento-osseous dysplasia 9.9
26 back pain 9.9
27 head injury 9.9
28 rapidly involuting congenital hemangioma 9.9
29 avascular necrosis 9.9
30 leukoencephalopathy, hereditary diffuse, with spheroids 9.6 TYROBP TREM2
31 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 9.6 TYROBP TREM2
32 basal ganglia calcification 9.6 TYROBP TREM2
33 dementia 9.4 TYROBP TREM2
34 disease of mental health 9.2 TYROBP TREM2 B2M

Graphical network of the top 20 diseases related to Solitary Bone Cyst:



Diseases related to Solitary Bone Cyst
Sources

Symptoms & Phenotypes for Solitary Bone Cyst

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Human phenotypes related to Solitary Bone Cyst:

58 31 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 unicameral bone cyst 58 31 hallmark (90%) Very frequent (99-80%) HP:0012064
2 bone pain 58 31 frequent (33%) Frequent (79-30%) HP:0002653
3 pathologic fracture 58 31 frequent (33%) Frequent (79-30%) HP:0002756
4 abnormality of the humeral diaphysis 58 31 frequent (33%) Frequent (79-30%) HP:0003926
5 proximal femoral metaphyseal abnormality 58 31 frequent (33%) Frequent (79-30%) HP:0006431
6 abnormality of the medullary cavity of the long bones 58 31 frequent (33%) Frequent (79-30%) HP:0100253
7 abnormality of tibia morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0002992
8 prominent calcaneus 58 31 occasional (7.5%) Occasional (29-5%) HP:0012428
9 abnormal form of the vertebral bodies 58 31 very rare (1%) Very rare (<4-1%) HP:0003312
10 back pain 58 31 very rare (1%) Very rare (<4-1%) HP:0003418
11 abnormality of the ilium 58 31 very rare (1%) Very rare (<4-1%) HP:0002867
12 muscular edema 58 31 very rare (1%) Very rare (<4-1%) HP:0100748
13 abnormality of the spinal cord 58 31 very rare (1%) Very rare (<4-1%) HP:0002143
14 abnormality of the pubic bone 58 31 very rare (1%) Very rare (<4-1%) HP:0003172
15 abnormal parietal bone morphology 58 31 very rare (1%) Very rare (<4-1%) HP:0002696
16 lytic defects of the radius 58 31 very rare (1%) Very rare (<4-1%) HP:0003979
17 abnormality of the nervous system 58 Very rare (<4-1%)
Sources

Drugs & Therapeutics for Solitary Bone Cyst

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Drugs for Solitary Bone Cyst (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 3
2 Calcium, Dietary Phase 3
3
Calcium Nutraceutical Phase 3 7440-70-2 271
4
Denosumab Approved Phase 2 615258-40-7
5 Mitogens Phase 1
6
Prednisolone Approved, Vet_approved 50-24-8 5755
7 Prednisolone acetate Approved, Vet_approved 52-21-1
8
Methylprednisolone hemisuccinate Approved 2921-57-5
9
Prednisolone phosphate Approved, Vet_approved 302-25-0
10
Methylprednisolone Approved, Vet_approved 83-43-2 6741
11
Prednisolone hemisuccinate Experimental 2920-86-7
12 Methylprednisolone Acetate

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Simple Bone Cysts in Kids (SBoCK) Recruiting NCT02193841 Phase 3
2 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
3 Regeneration of Maxillary Bone Cystic Cavities by Bio Implant of MSHV-H Cells Associated to a Cross-linked Serum Scaffold Completed NCT01389661 Phase 1, Phase 2
4 An Open-label, Multi-center, Phase 2 Study of Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab
5 Autologous Bone Tissue Constructed On Biodegradable Polymer for the Treatment of Aneurysmal Bone Cysts Recruiting NCT03066245 Phase 1, Phase 2
6 A Phase 2 Randomised, Open-label, Multi-centre Ascending Dose Study of the Efficacy, Safety and Tolerability of I-040302 Versus Control Injection (Bone Marrow Aspirate or Steroids) in Children and Young Adults With Solitary Bone Cysts Withdrawn NCT00459641 Phase 2 I-040302
7 Efficacy of Platelet-rich Plasma in Treatment of Mandibular Traumatic Bone Cyst Completed NCT01944410 Phase 1
8 Effect of Bone Marrow-derived Mesenchymal Stem Cell Transplantation in Reconstructing Bone Defects. Completed NCT01207193 Phase 1
9 The Results of Multiple Aspirations and Injections of Unicameral Bone Cyst by Methyl Prednisolone Acetate Unknown status NCT03724630
10 The Clinical Trial of the Safety and Efficacy of the Medical Device "Bone Substitute Based on Octacalcium Phosphate and Biologically Active Nucleic Acids for Bone Tissue Regeneration" (Nucleostim-VEGF) Completed NCT03076138
11 A Prospective, Longitudinal Patient Study on CERAMENTâ„¢|BONE VOID FILLER in Benign Bone Tumors Completed NCT02567084
12 A Randomized Clinical Trial Comparing Curettage With Allogenic Bone Grafting and Curettage With Bioactive Glass Filling in Children With Bone Cysts CYSTS Recruiting NCT04737590
13 Observational Prospective Multi-center International Study on the Use of Injectable Calcium Phosphate Cements for the Treatment of Bone Defects in Adults. Recruiting NCT02575352
14 A Longitudinal Outcomes Study of the Subchondroplasty® Procedure in the Hip Recruiting NCT03494660
15 Quantitative Ultrasound for the Evaluation of Simple Bone Cyst Healing Withdrawn NCT02616757

Search NIH Clinical Center for Solitary Bone Cyst

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Solitary Bone Cyst cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Solitary Bone Cyst:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Solitary Bone Cyst:
Bone marrow-derived mesenchymal stem cells (family)
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Genetic Tests for Solitary Bone Cyst

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Anatomical Context for Solitary Bone Cyst

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MalaCards organs/tissues related to Solitary Bone Cyst:

40
Bone, Bone Marrow, Spinal Cord, Salivary Gland
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Solitary Bone Cyst:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
Sources

Publications for Solitary Bone Cyst

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Articles related to Solitary Bone Cyst:

(show top 50) (show all 387)
# Title Authors PMID Year
1
Outcomes in Unicameral Bone Cyst Management Utilizing a Decision Tree Algorithm Approach. 61
33601461 2021
2
Comparison of three treatment methods for simple bone cyst in children. 61
33435945 2021
3
Cranial vault unicameral bone cyst. 61
30691312 2020
4
Concomitant cemento-osseous dysplasia and aneurysmal bone cyst of the mandible: a rare case report with literature review. 61
33036586 2020
5
[Tumor-like bony lesions of the skeleton]. 61
32840666 2020
6
[Tumor-like bony lesions of the skeleton]. 61
32556370 2020
7
Simple bone cyst of the hyoid: A radiological diagnosis and follow-up. 61
33113293 2020
8
Pediatric physeal slide-traction plate fixation for pathological distal femoral fracture caused by unicameral bone cyst in adolescents. 61
32727439 2020
9
Injectable calcium sulfate vs mixed bone graft of autologous iliac bone and allogeneic bone: Which is the better bone graft material for unicameral bone cyst in humerus? 61
32502025 2020
10
Biologic osteosynthesis in the treatment of benign and malignant bone tumors. 61
32557602 2020
11
A large maxillary cemento-ossifying fibroma superimposed with solitary bone cyst documented over 18 years: A case report. 61
32199251 2020
12
Hydatid disease of proximal femur treated using a mega prosthesis: A case report. 61
32120281 2020
13
Solitary Bone Cyst Like Areas in Myositis Ossificans: A Breast Mass in a Child. 61
31757181 2019
14
A Rare Case of Ossifying Fibroma with Cystic Degeneration: Diagnostic Challenge with Literature Review. 61
31742074 2019
15
Right iliac bone pathological fracture mimicking acute appendicitis. 61
30470602 2019
16
Free non-vascularized fibular graft reconstruction after resection of metacarpal unicameral bone cyst: A case report. 61
30847171 2019
17
Cartilage-sparing Arthroscopic Technique for Curettage and Bone Grafting of Cystic Lesion of Talus -A Case Report. 61
31245332 2019
18
Unicameral bone cyst in the pelvis: report of a case treated by placement of screws made from a composite of unsintered hydroxyapatite particles and poly-l-lactide. 61
31853343 2019
19
Explanation of radiological signs and fracture indices in a unicameral bone cyst. 61
31000953 2019
20
Continuous Surgical Decompression for Solitary Bone Cyst of the Jaw in a Teenage Patient. 61
31110825 2019
21
Solitary Bone Cyst of Posterior Maxilla: A Rare Presentation. 61
32015662 2019
22
Traumatic Bone Cyst of Mandible: A Case Report of Rare Entity and Review of Literature. 61
32015634 2019
23
Pathological Neck of Femur Fracture with Failed Osteosynthesis in Adolescent: A Report of Two Cases. 61
30915304 2018
24
Multiloculated solitary (unicameral) bone cyst in a young dog. 61
29782037 2018
25
Multiple lesions of skull and cervical spine: a rare presentation of unicameral bone cysts. 61
30012676 2018
26
Locking plate and fibular strut-graft augmentation in the reconstruction of unicameral bone cyst of proximal femur in the paediatric population. 61
28963665 2018
27
Giant Solitary Cyst at the Site of Knee Osteoarthritis: Treatment with a Synthetic Resorbable Bone Graft Substitute and Primary Total Knee Arthroplasty. 61
30123595 2018
28
Primary Tumor and Tumor-Like Lesions of Bones of the Foot: Single-Center Experience of 166 Cases. 61
29079234 2017
29
Treatment of Unicameral Bone Cysts of the Proximal Femur With Internal Fixation Lessens the Risk of Additional Surgery. 61
28817159 2017
30
Humerus Lengthening With the PRECICE Internal Lengthening Nail. 61
28244924 2017
31
Solitary bone cyst of a lumbar vertebra treated with percutaneous steroid injection: a case report and review of literature. 61
27554346 2017
32
Vertebral fracture due to a solitary bone cyst. 61
27882906 2017
33
[Incidental findings in musculoskeletal radiology]. 61
28289785 2017
34
Unicameral bone cyst of the calcaneus - minimally invasive endoscopic surgical treatment. Case report. 61
28730263 2017
35
Recurrence of a Unicameral Bone Cyst in the Femoral Diaphysis. 61
27904734 2016
36
Treatment options of simple bone cysts: the role of bone substitutes, growth factors and literature review. 61
28002914 2016
37
Unicameral Bone Cyst of the Medial Cuneiform. 61
27031385 2016
38
Bioceramic bone graft substitute for treatment of unicameral bone cysts. 61
27574267 2016
39
Regeneration of a Compromized Masticatory Unit in a Large Mandibular Defect Caused by a Huge Solitary Bone Cyst: A Case Report and Review of the Regenerative Literature. 61
27408457 2016
40
Decalcified allograft in repair of lytic lesions of bone: A study to evolve bone bank in developing countries. 61
27512226 2016
41
External fixation reconstruction of the residual problems of benign bone tumours. 61
26873644 2016
42
Malignant transformation of a unicameral bone cyst in a cat. 61
27041754 2016
43
Solitary bone cyst: a comparison of treatment options with special reference to their long-term outcome. 61
27075249 2016
44
Unicameral Bone Cyst of the Medial Cuneiform: A Case Report. 61
26886424 2016
45
Endoscopic resection and allografting for benign osteolytic lesions of the calcaneus. 61
27104115 2016
46
Case Report: An Unusual Finding of a Solitary Bone Cyst in a Patient with a Fractured Mandible. 61
26856006 2015
47
A comparison of treating Unicameral bone cyst using steroids and percutaneous autologous bone marrow aspiration injection. 61
26878509 2015
48
Pathological fractures of the proximal femur due to solitary bone cyst: classification, methods of treatment. 61
26664486 2015
49
Etiological aspects of solitary bone cysts: comments regarding the presence of the disease in two brothers. Is the genetic theory sustainable or is it pure coincidence? - Case report. 61
26664480 2015
50
Spontaneous Bone Regeneration After Enucleation of Large Jaw Cysts: A Digital Radiographic Analysis of 44 Consecutive Cases. 61
26501020 2015
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Variations for Solitary Bone Cyst

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Expression for Solitary Bone Cyst

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Search GEO for disease gene expression data for Solitary Bone Cyst.
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Pathways for Solitary Bone Cyst

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Pathways related to Solitary Bone Cyst according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Class I MHC mediated antigen processing and presentation 65
Show member pathways
 12.51 TYROBP TREM2 B2M
2
NF-kappaB Signaling 4
11.84 TYROBP B2M
3
Semaphorin interactions 65
Show member pathways
 11.65 TYROBP TREM2
4
Osteoclast differentiation 36
11.06 TYROBP TREM2
5
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 65
10.93 TYROBP TREM2 B2M
Sources

GO Terms for Solitary Bone Cyst

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Biological processes related to Solitary Bone Cyst according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.54 TYROBP TREM2 B2M
2 neutrophil degranulation GO:0043312 9.4 TYROBP B2M
3 regulation of immune response GO:0050776 9.33 TYROBP TREM2 B2M
4 osteoclast differentiation GO:0030316 9.32 TYROBP TREM2
5 apoptotic cell clearance GO:0043277 9.26 TYROBP TREM2
6 positive regulation of macrophage fusion GO:0034241 8.96 TYROBP TREM2
7 microglial cell activation involved in immune response GO:0002282 8.62 TYROBP TREM2
Sources

Sources for Solitary Bone Cyst

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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