MCID: SLT009
MIFTS: 34

Solitary Bone Cyst

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Solitary Bone Cyst

MalaCards integrated aliases for Solitary Bone Cyst:

Name: Solitary Bone Cyst 38 59
Unicameral Bone Cyst 59
Bone Cysts 73

Characteristics:

Orphanet epidemiological data:

59
solitary bone cyst
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 59  
Rare bone diseases


External Ids:

Orphanet 59 ORPHA83468
ICD10 via Orphanet 34 M85.4
UMLS via Orphanet 74 C0005937
ICD10 33 M85.4
UMLS 73 C0005937

Summaries for Solitary Bone Cyst

MalaCards based summary : Solitary Bone Cyst, also known as unicameral bone cyst, is related to aneurysmal bone cysts and chondrosarcoma. An important gene associated with Solitary Bone Cyst is TREM2 (Triggering Receptor Expressed On Myeloid Cells 2), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and NF-kappaB Signaling. The drugs Verteporfin and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone and bone marrow.

Wikipedia : 76 A unicameral bone cyst, also known as a simple bone cyst, is a cavity filled with a yellow-colored... more...

Related Diseases for Solitary Bone Cyst

Diseases related to Solitary Bone Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 aneurysmal bone cysts 10.2
2 chondrosarcoma 10.1
3 ewing sarcoma 10.1
4 acquired generalized lipodystrophy 10.1
5 degos 'en cocarde' erythrokeratoderma 10.1
6 osteitis fibrosa 10.0
7 coxa vara 9.8
8 osteochondritis dissecans 9.8
9 osteochondrosis 9.8
10 fibrous dysplasia 9.8
11 sarcoma 9.8
12 florid cemento-osseous dysplasia 9.8
13 idiopathic avascular necrosis 9.8
14 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 9.7 TREM2 TYROBP
15 dementia 9.6 TREM2 TYROBP

Graphical network of the top 20 diseases related to Solitary Bone Cyst:



Diseases related to Solitary Bone Cyst

Symptoms & Phenotypes for Solitary Bone Cyst

Drugs & Therapeutics for Solitary Bone Cyst

Drugs for Solitary Bone Cyst (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Verteporfin Approved, Investigational Phase 3 129497-78-5
2 Calcium, Dietary Phase 3,Not Applicable
3 Photosensitizing Agents Phase 3,Phase 2,Not Applicable
4 Dermatologic Agents Phase 3,Phase 2,Not Applicable
5
Denosumab Approved Phase 1, Phase 2,Phase 2 615258-40-7
6
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
7
Aminolevulinic acid Approved Phase 2,Phase 1,Not Applicable 106-60-5 137
8
Nicotinamide Approved, Investigational Phase 2 98-92-0 936
9
Tazarotene Approved, Investigational Phase 2 118292-40-3 5381
10
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
11
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
12
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
13
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
15 Bone Density Conservation Agents Phase 1, Phase 2,Phase 2,Not Applicable
16 Interferon-gamma Phase 1, Phase 2,Phase 2
17 interferons Phase 1, Phase 2
18 Pharmaceutical Solutions Phase 2,Not Applicable
19 Micronutrients Phase 2,Phase 1,Not Applicable
20 Vitamin B3 Phase 2
21 Nicotinic Acids Phase 2
22 Vitamin B9 Phase 2
23 Vitamins Phase 2,Phase 1,Not Applicable
24 Trace Elements Phase 2,Phase 1,Not Applicable
25 Keratolytic Agents Phase 2
26 Folate Phase 2
27 Vitamin B Complex Phase 2
28 Cyclooxygenase Inhibitors Phase 2
29 Antirheumatic Agents Phase 2
30 Anti-Inflammatory Agents, Non-Steroidal Phase 2
31 Cyclooxygenase 2 Inhibitors Phase 2
32 Analgesics, Non-Narcotic Phase 2
33 Peripheral Nervous System Agents Phase 2
34 Anti-Inflammatory Agents Phase 2
35 Analgesics Phase 2
36 Anti-Infective Agents Phase 2,Phase 1
37 Antifungal Agents Phase 2,Phase 1
38 Steroid Synthesis Inhibitors Phase 2
39 Cytochrome P-450 CYP3A Inhibitors Phase 2
40 Cytochrome P-450 Enzyme Inhibitors Phase 2
41
Hydroxyitraconazole Phase 2
42 Hormone Antagonists Phase 2
43 Hormones Phase 2
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
45
Sirolimus Approved, Investigational Phase 1 53123-88-9 46835353 6436030 5284616
46
Everolimus Approved Phase 1 159351-69-6 6442177
47
Vitamin D3 Approved, Nutraceutical Phase 1,Not Applicable 67-97-0 5280795 6221
48
Ergocalciferol Approved, Nutraceutical Phase 1,Not Applicable 50-14-6 5280793
49
Vitamin D Approved, Nutraceutical, Vet_approved Phase 1,Not Applicable 1406-16-2
50 Mitogens Phase 1

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 Simple Bone Cysts in Kids Recruiting NCT02193841 Phase 3
2 Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas (BCCs) in Subjects With Basal Cell Nevus Syndrome Not yet recruiting NCT03703310 Phase 3 Patidegib Topical Gel, 2%;Patidegib Topical Gel, Vehicle
3 Two Studies to Determine if Verteporfin PDT is Effective & Safe in Treating Multiple Basal Cell Carcinoma of the Skin. Terminated NCT00049959 Phase 3 verteporfin PDT
4 Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS) Withdrawn NCT03070691 Phase 2, Phase 3 LDE225B;Vehicle
5 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
6 Treatment Of Maxillary Bone Cysts With Autologous Bone Mesenchymal Stem Cells (MSV-H) Completed NCT01389661 Phase 1, Phase 2
7 Trial of Patidegib Gel 2%, 4%, and Vehicle to Decrease the Number of Surgically Eligible Basal Cell Carcinomas (BCC) in Gorlin Syndrome Patients Completed NCT02762084 Phase 2 patidegib;vehicle gel
8 A Study of the Efficacy and Safety of ASN-002 in Adult Patients With Low-risk Nodular Basal Cell Carcinoma Completed NCT02550678 Phase 1, Phase 2 5-FU
9 A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas Completed NCT01815840 Phase 2 Vismodegib;Placebo
10 Trial Comparing the Effects of Intermittent Vismodegib vs. PDT in Patients With Multiple Basal Cell Carcinomas Completed NCT01556009 Phase 2 Vismodegib;Aminolevulinic acid %20 topical solution
11 Efficacy, Safety and Pharmacokinetics of Oral LDE225 in Treatment of Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS) Completed NCT01350115 Phase 2 LDE225;Placebo
12 Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Face Completed NCT00489086 Phase 2 tazarotene
13 Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Chest and Back Completed NCT00783965 Phase 2 tazarotene
14 A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome Patients Completed NCT00961896 Phase 2 Vehicle;LDE225 0.25%;LDE225 0.75%
15 To Determine The Efficacy and Safety of GDC-0449 in Patients With Basal Cell Nevus Syndrome (BCNS) Completed NCT00957229 Phase 2 GDC-0449
16 Celecoxib in Preventing Basal Cell Carcinoma in Patients With Basal Cell Nevus Syndrome Completed NCT00023621 Phase 2 celecoxib
17 Use of Stem Cells Cultured on a Scaffold for the Treatment of Aneurysmal Bone Cysts (ABC) Recruiting NCT03066245 Phase 1, Phase 2
18 Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab
19 Open-label Trial of SUBA™-Itraconazole (SUBA-Cap) in Subjects With Basal Cell Carcinoma Nevus Syndrome (BCCNS) Active, not recruiting NCT02354261 Phase 2 SUBA-Itraconazole
20 Nivolumab With Vismodegib in Patients With Basal Cell Nevus Syndrome Not yet recruiting NCT03767439 Phase 2 Vismodegib;Nivolumab;Ipilimumab
21 Study of ASN-002 to Treat Basal Cell Carcinomas (BCCs) in Individuals With Basal Cell Nevus Syndrome (BCNS) Suspended NCT03208296 Phase 1, Phase 2
22 Safety and Tolerability of I-040302 in Children and Young Adults With Solitary Bone Cysts Withdrawn NCT00459641 Phase 2 I-040302
23 Lumbar Degenerative Disc Disease Treatment With Bone Marrow Autologous Mesenchymal Stem Cells (MSV) Withdrawn NCT02440074 Phase 1, Phase 2
24 Use of PRP in Treatment of Mandibular Traumatic Bone Cyst Completed NCT01944410 Phase 1
25 Treatment Of Bone Cyst With Bone Marrow Mesenchymal Cell Transplantation Completed NCT01207193 Phase 1
26 Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas Completed NCT02639117 Phase 1 Vismodegib
27 Topical Sirolimus in Patients With Basal Cell Nevus Syndrome and in Healthy Participants Completed NCT00433485 Phase 1 sirolimus
28 Vitamin D and Photodynamic Therapy for Treatment of BCC in BCNS Recruiting NCT03483441 Phase 1 PDT
29 Osteoconduction Potential of an Injectable Calcium Phosphate in Orthopaedic Surgery in Fillings of Osseous Defects Unknown status NCT00206791 Not Applicable
30 Complete Twelve Month Bone Remodeling With a Bi-phasic Injectable Bone Substitute in Benign Bone Tumors Completed NCT02567084 Not Applicable
31 Safety and Efficacy Study of HYTOP® in the Treatment of Focal Chondral Defects. Completed NCT01791062 Not Applicable
32 Blue vs Red Light During Levulan Based Photodynamic Therapy in Patients With Basal Cell Nevus Syndrome Completed NCT02157623 Not Applicable Levulan
33 Study of BMS-833923 in Two Specific Patients With Basal Cell Nevus Syndrome Completed NCT02100371 Not Applicable BMS-833923
34 Use of an SPF30 Sunscreen and an After-sun-lotion in Skin Cancer Risk Patients Completed NCT00555633
35 Isotretinoin in Preventing Skin Cancer Completed NCT00025012 Not Applicable isotretinoin
36 The Evaluation of Oral Acitretin in the Treatment of Psoriasis, Cutaneous Disorders of Keratinization, Multiple Basal Cell Carcinomas and Other Retinoid Responsive Diseases Completed NCT00005660
37 Quantitative Ultrasound for the Evaluation of Simple Bone Cyst Healing Recruiting NCT02616757 Not Applicable
38 Calcium Phosphate Cement Registry (CPC Registry) Recruiting NCT02575352
39 SCP Hip Outcomes Study Recruiting NCT03494660
40 Vitamin D as a Nutritional Neoadjuvant During Photodynamic Therapy of Basal Cell Carcinoma Recruiting NCT03467789 Not Applicable
41 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
42 Gene-activated Bone Substitute for Maxillofacial Bone Regeneration Enrolling by invitation NCT03076138 Not Applicable
43 The Results of Multiple Aspirations and Injections of Unicameral Bone Cyst by Methyl Prednisolone Acetate Not yet recruiting NCT03724630
44 Knee Osteoarthritis: Platelet Rich Plasma or Hyaluronic Acid Not yet recruiting NCT03801564 Not Applicable

Search NIH Clinical Center for Solitary Bone Cyst

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Solitary Bone Cyst cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Solitary Bone Cyst:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Solitary Bone Cyst:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Solitary Bone Cyst

Anatomical Context for Solitary Bone Cyst

MalaCards organs/tissues related to Solitary Bone Cyst:

41
Bone, Bone Marrow
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Solitary Bone Cyst:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Solitary Bone Cyst

Articles related to Solitary Bone Cyst:

(show top 50) (show all 104)
# Title Authors Year
1
Locking plate and fibular strut-graft augmentation in the reconstruction of unicameral bone cyst of proximal femur in the paediatric population. ( 28963665 )
2018
2
Multiloculated solitary (unicameral) bone cyst in a young dog. ( 29782037 )
2018
3
Vertebral fracture due to a solitary bone cyst. ( 27882906 )
2017
4
Unicameral bone cyst of the calcaneus - minimally invasive endoscopic surgical treatment. Case report. ( 28730263 )
2017
5
Regeneration of a Compromized Masticatory Unit in a Large Mandibular Defect Caused by a Huge Solitary Bone Cyst: A Case Report and Review of the Regenerative Literature. ( 27408457 )
2016
6
Solitary bone cyst: a comparison of treatment options with special reference to their long-term outcome. ( 27075249 )
2016
7
Solitary bone cyst of a lumbar vertebra treated with percutaneous steroid injection: a case report and review of literature. ( 27554346 )
2016
8
Unicameral Bone Cyst of the Medial Cuneiform: A Case Report. ( 26886424 )
2016
9
Unicameral Bone Cyst of the Medial Cuneiform. ( 27031385 )
2016
10
Malignant transformation of a unicameral bone cyst in a cat. ( 27041754 )
2016
11
Recurrence of a Unicameral Bone Cyst in the Femoral Diaphysis. ( 27904734 )
2016
12
Case Report: An Unusual Finding of a Solitary Bone Cyst in a Patient with a Fractured Mandible. ( 26856006 )
2015
13
Pathological fractures of the proximal femur due to solitary bone cyst: classification, methods of treatment. ( 26664486 )
2015
14
Treatment of a unicameral bone cyst in a dog using a customized titanium device. ( 25319515 )
2015
15
Unicameral Bone Cyst in the Calcaneus of Mirror Image Twins. ( 25435010 )
2015
16
Unicameral bone cyst of the patella in a young dog. ( 26299878 )
2015
17
A comparison of treating Unicameral bone cyst using steroids and percutaneous autologous bone marrow aspiration injection. ( 26878509 )
2015
18
Solitary bone cyst of the mandible: a case report and brief review of literature. ( 25080544 )
2014
19
Solitary bone cyst of the odontoid process and body of the axis: a case report. ( 25430716 )
2014
20
Ewing Sarcoma After Treatment of a Unicameral Bone Cyst of the Proximal Part of the Humerus. ( 29252522 )
2014
21
Treatment of unicameral bone cyst: systematic review and meta analysis. ( 24570274 )
2014
22
Pathologic fracture of the distal radius in a 25-year-old patient with a large unicameral bone cyst. ( 24925068 )
2014
23
Management of unicameral bone cyst by using freeze dried radiation sterilized bone allograft impregnate with autogenous bone marrow. ( 25178604 )
2014
24
Traumatic bone cyst or solitary bone cyst. ( 23576660 )
2013
25
Endoscopic Surgery for Symptomatic Unicameral Bone Cyst of the Proximal Femur. ( 24892010 )
2013
26
Radiology quiz case 2. Solitary bone cyst. ( 22801896 )
2012
27
Intraoral endoscopic enucleation of a solitary bone cyst of the mandibular condyle. ( 22024140 )
2012
28
Limb shortening in the course of solitary bone cyst treatment--a comparative study. ( 20521146 )
2011
29
Trauma, solitary bone cyst and delayed eruption of permanent mandibular incisors. an unusual case in a 7-year-old patient. ( 21993070 )
2011
30
An atypical presentation of a solitary bone cyst of the mandibular ramus: a case report. ( 21112792 )
2011
31
Solitary bone cyst. ( 21525701 )
2011
32
Clinical outcome following surgical intervention for a solitary bone cyst: emphasis on treatment by curettage and steroid injection. ( 20721725 )
2010
33
Evaluation of volume and solitary bone cyst remodeling using conventional radiological examination. ( 19440706 )
2010
34
Solitary bone cyst. ( 20405250 )
2010
35
The unusual cyst: solitary bone cyst of the jaws. ( 19927460 )
2009
36
Long-term progression of a solitary bone cyst: a case report. ( 19284193 )
2008
37
Solitary bone cyst of the jaws: a review of the etiopathogenic hypotheses. ( 18940504 )
2008
38
Mirror-image solitary bone cyst of the humerus in a pair of mirror-image monozygotic twins. ( 18175134 )
2008
39
The growth rate of the humerus: long-term follow-up of treatment of solitary bone cyst of the proximal humerus using cannulated screws: a case report. ( 18391814 )
2008
40
Simple (unicameral) bone cyst of the calcaneus: a pathologic variant revisited. ( 18633767 )
2008
41
Solitary bone cyst. ( 16617942 )
2006
42
Recurrence of a solitary bone cyst of the mandible: case report. ( 15993287 )
2005
43
Steroid injection therapy in a feline solitary bone cyst. ( 12736437 )
2003
44
Management of florid cemento-osseous dysplasia of the mandible producing solitary bone cyst: report of a case. ( 12089703 )
2002
45
Solitary bone cyst in L-2. Case illustration. ( 12120643 )
2002
46
Surgical treatment and follow-up of solitary bone cyst of the mandible:a report of seven cases. ( 11384121 )
2001
47
TP53 mutations in a recurrent unicameral bone cyst. ( 11252305 )
2001
48
Development of a solitary bone cyst--a report of a case suggesting its pathogenesis. ( 10968539 )
2000
49
A solitary bone cyst in the spinous process of the cervical spine: a case report. ( 10749645 )
2000
50
Unusual finding after contrast injection of a solitary bone cyst. A case report. ( 10427808 )
1999

Variations for Solitary Bone Cyst

Expression for Solitary Bone Cyst

Search GEO for disease gene expression data for Solitary Bone Cyst.

GO Terms for Solitary Bone Cyst

Biological processes related to Solitary Bone Cyst according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.33 B2M TREM2 TYROBP
2 neutrophil degranulation GO:0043312 9.26 B2M TYROBP
3 osteoclast differentiation GO:0030316 8.96 TREM2 TYROBP
4 regulation of immune response GO:0050776 8.8 B2M TREM2 TYROBP

Sources for Solitary Bone Cyst

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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