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MCID: SLT009
MIFTS: 37

Solitary Bone Cyst

Categories: Bone diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Solitary Bone Cyst

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MalaCards integrated aliases for Solitary Bone Cyst:

Name: Solitary Bone Cyst 39 60
Unicameral Bone Cyst 60
Bone Cysts 74

Characteristics:

Orphanet epidemiological data:

60
solitary bone cyst
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 34 35
Orphanet: 60  
Rare bone diseases


External Ids:

ICD10 34 M85.4
ICD10 via Orphanet 35 M85.4
UMLS via Orphanet 75 C0005937
Orphanet 60 ORPHA83468
UMLS 74 C0005937
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Summaries for Solitary Bone Cyst

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MalaCards based summary : Solitary Bone Cyst, also known as unicameral bone cyst, is related to aneurysmal bone cysts and chondrosarcoma. An important gene associated with Solitary Bone Cyst is TREM2 (Triggering Receptor Expressed On Myeloid Cells 2), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and NF-kappaB Signaling. The drugs Verteporfin and Calcium have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone and skin.

Sources

Related Diseases for Solitary Bone Cyst

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Diseases related to Solitary Bone Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 aneurysmal bone cysts 10.4
2 chondrosarcoma 10.1
3 ewing sarcoma 10.1
4 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.1
5 acquired generalized lipodystrophy 10.1
6 degos 'en cocarde' erythrokeratoderma 10.1
7 osteitis fibrosa 10.1
8 bone inflammation disease 10.1
9 coxa vara 9.8
10 osteochondritis dissecans 9.8
11 osteochondrosis 9.8
12 fibrous dysplasia 9.8
13 sarcoma 9.8
14 florid cemento-osseous dysplasia 9.8
15 idiopathic avascular necrosis 9.8
16 dementia 9.4 TREM2 TYROBP

Graphical network of the top 20 diseases related to Solitary Bone Cyst:



Diseases related to Solitary Bone Cyst
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Symptoms & Phenotypes for Solitary Bone Cyst

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Drugs & Therapeutics for Solitary Bone Cyst

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Drugs for Solitary Bone Cyst (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Verteporfin Approved, Investigational Phase 3 129497-78-5
2
Calcium Approved, Nutraceutical Phase 3,Phase 1,Not Applicable 7440-70-2 271
3 Calcium, Dietary Phase 3,Phase 1,Not Applicable
4 Antihypertensive Agents Phase 3,Phase 2
5 Veratrum Alkaloids Phase 3,Phase 2
6 Dermatologic Agents Phase 3,Phase 2,Not Applicable
7 Photosensitizing Agents Phase 3,Phase 2,Not Applicable
8
Denosumab Approved Phase 1, Phase 2,Phase 2 615258-40-7
9
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
10
Aminolevulinic acid Approved Phase 2,Phase 1,Not Applicable 106-60-5 137
11
Tazarotene Approved, Investigational Phase 2 118292-40-3 5381
12
Nicotinamide Approved, Investigational Phase 2 98-92-0 936
13
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
14
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
15
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
16
leucovorin Approved Phase 2 58-05-9 143 6006
17
Etoposide Approved Phase 2 33419-42-0 36462
18
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
19
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
20
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
21
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
22
nivolumab Approved Phase 2 946414-94-4
23
Ipilimumab Approved Phase 2 477202-00-9
24
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
25
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
26
Emodepside Investigational, Vet_approved Phase 2 155030-63-0
27 Hormones Phase 2,Phase 1,Not Applicable
28 Bone Density Conservation Agents Phase 1, Phase 2,Phase 2,Not Applicable
29 Interferon-gamma Phase 1, Phase 2,Phase 2
30 interferons Phase 1, Phase 2
31 Pharmaceutical Solutions Phase 2,Not Applicable
32 Vitamin B3 Phase 2
33 Folate Phase 2
34 Vitamin B9 Phase 2
35 Keratolytic Agents Phase 2
36 Micronutrients Phase 2,Phase 1,Not Applicable
37 Nicotinic Acids Phase 2
38 Trace Elements Phase 2,Phase 1,Not Applicable
39 Vitamins Phase 2,Phase 1,Not Applicable
40 Nutrients Phase 2,Phase 1,Not Applicable
41 Vitamin B Complex Phase 2
42 Analgesics, Non-Narcotic Phase 2
43 Antirheumatic Agents Phase 2
44 Analgesics Phase 2
45 Anti-Inflammatory Agents Phase 2
46 Peripheral Nervous System Agents Phase 2
47 Anti-Inflammatory Agents, Non-Steroidal Phase 2
48 Cyclooxygenase 2 Inhibitors Phase 2
49 Cyclooxygenase Inhibitors Phase 2
50 Anti-Infective Agents Phase 2,Phase 1

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Simple Bone Cysts in Kids Recruiting NCT02193841 Phase 3
2 Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas (BCCs) in Subjects With Basal Cell Nevus Syndrome Recruiting NCT03703310 Phase 3 Patidegib Topical Gel, 2%;Patidegib Topical Gel, Vehicle
3 Two Studies to Determine if Verteporfin PDT is Effective & Safe in Treating Multiple Basal Cell Carcinoma of the Skin. Terminated NCT00049959 Phase 3 verteporfin PDT
4 Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS) Withdrawn NCT03070691 Phase 2, Phase 3 LDE225B;Vehicle
5 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
6 Treatment Of Maxillary Bone Cysts With Autologous Bone Mesenchymal Stem Cells (MSV-H) Completed NCT01389661 Phase 1, Phase 2
7 Trial of Patidegib Gel 2%, 4%, and Vehicle to Decrease the Number of Surgically Eligible Basal Cell Carcinomas (BCC) in Gorlin Syndrome Patients Completed NCT02762084 Phase 2 patidegib;vehicle gel
8 A Study of the Efficacy and Safety of ASN-002 in Adult Patients With Low-risk Nodular Basal Cell Carcinoma Completed NCT02550678 Phase 1, Phase 2 5-FU
9 A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas Completed NCT01815840 Phase 2 Vismodegib;Placebo
10 Trial Comparing the Effects of Intermittent Vismodegib vs. PDT in Patients With Multiple Basal Cell Carcinomas Completed NCT01556009 Phase 2 Vismodegib;Aminolevulinic acid %20 topical solution
11 Efficacy, Safety and Pharmacokinetics of Oral LDE225 in Treatment of Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS) Completed NCT01350115 Phase 2 LDE225;Placebo
12 Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Face Completed NCT00489086 Phase 2 tazarotene
13 Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Chest and Back Completed NCT00783965 Phase 2 tazarotene
14 A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome Patients Completed NCT00961896 Phase 2 Vehicle;LDE225 0.25%;LDE225 0.75%
15 To Determine The Efficacy and Safety of GDC-0449 in Patients With Basal Cell Nevus Syndrome (BCNS) Completed NCT00957229 Phase 2 GDC-0449
16 Celecoxib in Preventing Basal Cell Carcinoma in Patients With Basal Cell Nevus Syndrome Completed NCT00023621 Phase 2 celecoxib
17 Use of Stem Cells Cultured on a Scaffold for the Treatment of Aneurysmal Bone Cysts (ABC) Recruiting NCT03066245 Phase 1, Phase 2
18 Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab
19 Open-label Trial of SUBAâ„¢-Itraconazole (SUBA-Cap) in Subjects With Basal Cell Carcinoma Nevus Syndrome (BCCNS) Active, not recruiting NCT02354261 Phase 2 SUBA-Itraconazole
20 Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-metastatic Desmoplastic Medulloblastoma Active, not recruiting NCT02017964 Phase 2 Carboplatin;Cyclophosphamide;Etoposide;Methotrexate;Vincristine Sulfate
21 Nivolumab With Vismodegib in Patients With Basal Cell Nevus Syndrome Not yet recruiting NCT03767439 Phase 2 Vismodegib;Nivolumab;Ipilimumab
22 Study of ASN-002 to Treat Basal Cell Carcinomas (BCCs) in Individuals With Basal Cell Nevus Syndrome (BCNS) Suspended NCT03208296 Phase 1, Phase 2
23 Pilot Study of Sonidegib and Buparlisib in Treating Patients With Advanced or Metastatic Basal Cell Carcinoma Terminated NCT02303041 Phase 2 Buparlisib;Sonidegib
24 Safety and Tolerability of I-040302 in Children and Young Adults With Solitary Bone Cysts Withdrawn NCT00459641 Phase 2 I-040302
25 Lumbar Degenerative Disc Disease Treatment With Bone Marrow Autologous Mesenchymal Stem Cells (MSV) Withdrawn NCT02440074 Phase 1, Phase 2
26 Use of PRP in Treatment of Mandibular Traumatic Bone Cyst Completed NCT01944410 Phase 1
27 Treatment Of Bone Cyst With Bone Marrow Mesenchymal Cell Transplantation Completed NCT01207193 Phase 1
28 Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas Completed NCT02639117 Phase 1 Vismodegib
29 Topical Sirolimus in Patients With Basal Cell Nevus Syndrome and in Healthy Participants Completed NCT00433485 Phase 1 sirolimus
30 Vitamin D and Photodynamic Therapy for Treatment of BCC in BCNS Recruiting NCT03483441 Phase 1 PDT
31 Osteoconduction Potential of an Injectable Calcium Phosphate in Orthopaedic Surgery in Fillings of Osseous Defects Unknown status NCT00206791 Not Applicable
32 Complete Twelve Month Bone Remodeling With a Bi-phasic Injectable Bone Substitute in Benign Bone Tumors Completed NCT02567084 Not Applicable
33 Gene-activated Bone Substitute for Maxillofacial Bone Regeneration Completed NCT03076138 Not Applicable
34 Safety and Efficacy Study of HYTOP® in the Treatment of Focal Chondral Defects. Completed NCT01791062 Not Applicable
35 Blue vs Red Light During Levulan Based Photodynamic Therapy in Patients With Basal Cell Nevus Syndrome Completed NCT02157623 Not Applicable Levulan
36 Study of BMS-833923 in Two Specific Patients With Basal Cell Nevus Syndrome Completed NCT02100371 Not Applicable BMS-833923
37 Use of an SPF30 Sunscreen and an After-sun-lotion in Skin Cancer Risk Patients Completed NCT00555633
38 Isotretinoin in Preventing Skin Cancer Completed NCT00025012 Not Applicable isotretinoin
39 The Evaluation of Oral Acitretin in the Treatment of Psoriasis, Cutaneous Disorders of Keratinization, Multiple Basal Cell Carcinomas and Other Retinoid Responsive Diseases Completed NCT00005660
40 Quantitative Ultrasound for the Evaluation of Simple Bone Cyst Healing Recruiting NCT02616757 Not Applicable
41 Calcium Phosphate Cement Registry (CPC Registry) Recruiting NCT02575352
42 SCP Hip Outcomes Study Recruiting NCT03494660
43 Vitamin D as a Nutritional Neoadjuvant During Photodynamic Therapy of Basal Cell Carcinoma Recruiting NCT03467789 Not Applicable
44 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
45 The Results of Multiple Aspirations and Injections of Unicameral Bone Cyst by Methyl Prednisolone Acetate Not yet recruiting NCT03724630
46 Knee Osteoarthritis: Platelet Rich Plasma or Hyaluronic Acid Not yet recruiting NCT03801564 Not Applicable

Search NIH Clinical Center for Solitary Bone Cyst

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Solitary Bone Cyst cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Solitary Bone Cyst:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Solitary Bone Cyst:
Bone marrow-derived mesenchymal stem cells (family)
Sources

Genetic Tests for Solitary Bone Cyst

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Anatomical Context for Solitary Bone Cyst

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MalaCards organs/tissues related to Solitary Bone Cyst:

42
Bone, Skin, Bone Marrow
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Solitary Bone Cyst:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
Sources

Publications for Solitary Bone Cyst

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Articles related to Solitary Bone Cyst:

(show top 50) (show all 206)
# Title Authors Year
1
Continuous Surgical Decompression for Solitary Bone Cyst of the Jaw in a Teenage Patient. ( 31110825 )
2019
2
Cranial vault unicameral bone cyst. ( 30691312 )
2019
3
Free non-vascularized fibular graft reconstruction after resection of metacarpal unicameral bone cyst: A case report. ( 30847171 )
2019
4
Explanation of radiological signs and fracture indices in a unicameral bone cyst. ( 31000953 )
2019
5
Locking plate and fibular strut-graft augmentation in the reconstruction of unicameral bone cyst of proximal femur in the paediatric population. ( 28963665 )
2018
6
Multiloculated solitary (unicameral) bone cyst in a young dog. ( 29782037 )
2018
7
Solitary bone cyst of a lumbar vertebra treated with percutaneous steroid injection: a case report and review of literature. ( 27554346 )
2017
8
Vertebral fracture due to a solitary bone cyst. ( 27882906 )
2017
9
Unicameral bone cyst of the calcaneus - minimally invasive endoscopic surgical treatment. Case report. ( 28730263 )
2017
10
Solitary bone cyst: a comparison of treatment options with special reference to their long-term outcome. ( 27075249 )
2016
11
Regeneration of a Compromized Masticatory Unit in a Large Mandibular Defect Caused by a Huge Solitary Bone Cyst: A Case Report and Review of the Regenerative Literature. ( 27408457 )
2016
12
Unicameral Bone Cyst of the Medial Cuneiform: A Case Report. ( 26886424 )
2016
13
Unicameral Bone Cyst of the Medial Cuneiform. ( 27031385 )
2016
14
Malignant transformation of a unicameral bone cyst in a cat. ( 27041754 )
2016
15
Recurrence of a Unicameral Bone Cyst in the Femoral Diaphysis. ( 27904734 )
2016
16
Pathological fractures of the proximal femur due to solitary bone cyst: classification, methods of treatment. ( 26664486 )
2015
17
Case Report: An Unusual Finding of a Solitary Bone Cyst in a Patient with a Fractured Mandible. ( 26856006 )
2015
18
Treatment of a unicameral bone cyst in a dog using a customized titanium device. ( 25319515 )
2015
19
Unicameral Bone Cyst in the Calcaneus of Mirror Image Twins. ( 25435010 )
2015
20
Unicameral bone cyst of the patella in a young dog. ( 26299878 )
2015
21
A comparison of treating Unicameral bone cyst using steroids and percutaneous autologous bone marrow aspiration injection. ( 26878509 )
2015
22
Ewing Sarcoma After Treatment of a Unicameral Bone Cyst of the Proximal Part of the Humerus. ( 29252522 )
2014
23
Solitary bone cyst of the mandible: a case report and brief review of literature. ( 25080544 )
2014
24
Solitary bone cyst of the odontoid process and body of the axis: a case report. ( 25430716 )
2014
25
Treatment of unicameral bone cyst: systematic review and meta analysis. ( 24570274 )
2014
26
Pathologic fracture of the distal radius in a 25-year-old patient with a large unicameral bone cyst. ( 24925068 )
2014
27
Management of unicameral bone cyst by using freeze dried radiation sterilized bone allograft impregnate with autogenous bone marrow. ( 25178604 )
2014
28
Traumatic bone cyst or solitary bone cyst. ( 23576660 )
2013
29
Endoscopic Surgery for Symptomatic Unicameral Bone Cyst of the Proximal Femur. ( 24892010 )
2013
30
Intraoral endoscopic enucleation of a solitary bone cyst of the mandibular condyle. ( 22024140 )
2012
31
Radiology quiz case 2. Solitary bone cyst. ( 22801896 )
2012
32
Unicameral bone cyst of the hyoid. ( 21676942 )
2012
33
Unicameral bone cyst of the calcaneus. ( 22236658 )
2012
34
Three-part head-splitting proximal humerus fracture through a unicameral bone cyst. ( 22691682 )
2012
35
Unicameral bone cyst: radiographic assessment of venous outflow by cystography as a prognostic index. ( 22751482 )
2012
36
Minimal invasive surgery for unicameral bone cyst using demineralized bone matrix: a case series. ( 22839754 )
2012
37
Unicameral bone cyst of the scaphoid: a report of two cases. ( 22933687 )
2012
38
Unicameral bone cyst of the proximal tibia in a five year old girl. ( 23248665 )
2012
39
Limb shortening in the course of solitary bone cyst treatment--a comparative study. ( 20521146 )
2011
40
An atypical presentation of a solitary bone cyst of the mandibular ramus: a case report. ( 21112792 )
2011
41
Solitary bone cyst. ( 21525701 )
2011
42
Trauma, solitary bone cyst and delayed eruption of permanent mandibular incisors. an unusual case in a 7-year-old patient. ( 21993070 )
2011
43
Endoscopic surgery for young athletes with symptomatic unicameral bone cyst of the calcaneus. ( 21212309 )
2011
44
Treatment of unicameral bone cyst: surgical technique. ( 21411690 )
2011
45
Fracture risk in unicameral bone cyst. Is magnetic resonance imaging a better predictor than plain radiography? ( 21667736 )
2011
46
Distance from the growth plate and Its relation to the outcome of unicameral bone cyst treatment. ( 22468159 )
2011
47
Evaluation of volume and solitary bone cyst remodeling using conventional radiological examination. ( 19440706 )
2010
48
Solitary bone cyst. ( 20405250 )
2010
49
Clinical outcome following surgical intervention for a solitary bone cyst: emphasis on treatment by curettage and steroid injection. ( 20721725 )
2010
50
Treatment of a unicameral bone cyst of calcaneus with endoscopic curettage and percutaneous filling with corticocancellous allograft. ( 20123299 )
2010
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Variations for Solitary Bone Cyst

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Expression for Solitary Bone Cyst

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Search GEO for disease gene expression data for Solitary Bone Cyst.
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Pathways for Solitary Bone Cyst

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Pathways related to Solitary Bone Cyst according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Class I MHC mediated antigen processing and presentation 67
Show member pathways
 12.61 B2M TREM2 TYROBP
2
NF-kappaB Signaling 4
11.88 B2M TYROBP
3
Semaphorin interactions 67
Show member pathways
 11.72 TREM2 TYROBP
4
Osteoclast differentiation 38
11.26 TREM2 TYROBP
5
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 67
10.93 B2M TREM2 TYROBP
6
Microglia Activation During Neuroinflammation: Steady-State Microglia 66
10.61 TREM2 TYROBP
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GO Terms for Solitary Bone Cyst

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Biological processes related to Solitary Bone Cyst according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.33 B2M TREM2 TYROBP
2 neutrophil degranulation GO:0043312 9.26 B2M TYROBP
3 osteoclast differentiation GO:0030316 8.96 TREM2 TYROBP
4 regulation of immune response GO:0050776 8.8 B2M TREM2 TYROBP
Sources

Sources for Solitary Bone Cyst

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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