MCID: SLT017
MIFTS: 30

Solitary Mastocytoma of the Skin

Categories: Blood diseases, Cancer diseases, Skin diseases
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Aliases & Classifications for Solitary Mastocytoma of the Skin

MalaCards integrated aliases for Solitary Mastocytoma of the Skin:

Name: Solitary Mastocytoma of the Skin 11
Cutaneous Solitary Mastocytoma 11 14
Solitary Mastocytoma 11 75
Skin Mastocytoma 16 71
Solitary Mastocytoma of Skin 11
Mastocytoma, Skin 43

Classifications:



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Disease Ontology 11 DOID:3666
MeSH 43 D054705
NCIt 49 C7138
SNOMED-CT 68 239147000
UMLS 71 C0343115

Summaries for Solitary Mastocytoma of the Skin

Disease Ontology: 11 A mast cell neoplasm that is characterized by collections of mast cells with a single or multiple (usually five or fewer individual) orange-brown to red-brown plaques or nodules ranging from 0.5 to 3.5 cm in diameter.

MalaCards based summary: Solitary Mastocytoma of the Skin, also known as cutaneous solitary mastocytoma, is related to mast cell neoplasm and mastocytosis, cutaneous. An important gene associated with Solitary Mastocytoma of the Skin is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic Stem Cells and Lineage-specific Markers. Affiliated tissues include skin and smooth muscle, and related phenotypes are immune system and hematopoietic system

Wikipedia: 75 Solitary mastocytoma may be present at birth or may develop during the first weeks of life, originating... more...

Related Diseases for Solitary Mastocytoma of the Skin

Diseases related to Solitary Mastocytoma of the Skin via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 mast cell neoplasm 30.6 SERPINA3 KITLG KIT CMA1 CD2
2 mastocytosis, cutaneous 30.4 TPSAB1 KITLG KIT CMA1 CD2
3 urticaria 30.4 KIT ENPP3 CMA1
4 mastocytosis 29.7 TPSAB1 KITLG KIT ENPP3 CD2
5 systemic mastocytosis 29.6 TPSAB1 KITLG KIT CD2
6 gastrointestinal stromal tumor 29.4 SERPINA3 KITLG KIT CLEC11A
7 cutaneous mastocytoma 11.5
8 epithelioid leiomyosarcoma 10.2 SERPINA3 KIT
9 liver sarcoma 10.2 SERPINA3 KIT
10 heart sarcoma 10.2 SERPINA3 KIT
11 breast malignant phyllodes tumor 10.2 SERPINA3 KIT
12 heart cancer 10.2 SERPINA3 KIT
13 tenosynovial giant cell tumor 10.2 SERPINA3 KIT
14 malignant spindle cell melanoma 10.2 SERPINA3 KIT
15 deafness, autosomal dominant 69 10.2 KITLG KIT
16 pleomorphic liposarcoma 10.2 SERPINA3 KIT
17 histiocytic and dendritic cell cancer 10.2 SERPINA3 KIT
18 dysgerminoma 10.2 KITLG KIT
19 perivascular tumor 10.2 SERPINA3 KIT
20 dysgerminoma of ovary 10.2 KITLG KIT
21 salivary gland adenoid cystic carcinoma 10.2 SERPINA3 KIT
22 amelanotic melanoma 10.2 SERPINA3 KIT
23 hemangiopericytoma, malignant 10.2 SERPINA3 KIT
24 hyperpigmentation with or without hypopigmentation, familial progressive 10.2 KITLG KIT
25 brain germinoma 10.2 KITLG KIT
26 pseudosarcomatous fibromatosis 10.2 SERPINA3 KIT
27 dowling-degos disease 1 10.2 KITLG KIT
28 laryngeal small cell carcinoma 10.2 KITLG KIT
29 thoracic benign neoplasm 10.2 SERPINA3 KIT
30 cutaneous fibrous histiocytoma 10.2 SERPINA3 KITLG
31 lentigines 10.2 KITLG KIT
32 mixed cell type cancer 10.2 SERPINA3 KIT
33 smooth muscle tumor 10.2 SERPINA3 KIT
34 mesenchymal cell neoplasm 10.2 SERPINA3 KIT
35 well-differentiated liposarcoma 10.2 SERPINA3 KIT
36 connective tissue benign neoplasm 10.1 SERPINA3 KIT
37 plexiform neurofibroma 10.1 KITLG KIT
38 testicular germ cell tumor 10.1 KITLG KIT
39 tonsil cancer 10.1 SERPINA3 KIT
40 spindle cell sarcoma 10.1 SERPINA3 KIT
41 lipomatosis, multiple 10.1 SERPINA3 KIT
42 lethal midline granuloma 10.1 SERPINA3 CD2
43 cholinergic urticaria 10.1 SERPINA3 ENPP3
44 salivary gland disease 10.1 SERPINA3 KIT
45 myxofibrosarcoma 10.1 SERPINA3 KIT
46 acute erythroid leukemia 10.1 KITLG KIT
47 acute basophilic leukemia 10.1 KIT ENPP3
48 co-trimoxazole allergy 10.1 KIT ENPP3
49 vascular cancer 10.1 SERPINA3 KIT
50 cephalosporin allergy 10.1 ENPP3 CMA1

Graphical network of the top 20 diseases related to Solitary Mastocytoma of the Skin:



Diseases related to Solitary Mastocytoma of the Skin

Symptoms & Phenotypes for Solitary Mastocytoma of the Skin

MGI Mouse Phenotypes related to Solitary Mastocytoma of the Skin:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.5 CMA1 ENPP3 KIT KITLG SERPINA3 TPSAB1
2 hematopoietic system MP:0005397 9.23 CLEC11A CMA1 ENPP3 KIT KITLG SERPINA3

Drugs & Therapeutics for Solitary Mastocytoma of the Skin

Search Clinical Trials, NIH Clinical Center for Solitary Mastocytoma of the Skin

Cochrane evidence based reviews: mastocytoma, skin

Genetic Tests for Solitary Mastocytoma of the Skin

Anatomical Context for Solitary Mastocytoma of the Skin

Organs/tissues related to Solitary Mastocytoma of the Skin:

MalaCards : Skin, Smooth Muscle

Publications for Solitary Mastocytoma of the Skin

Articles related to Solitary Mastocytoma of the Skin:

(show top 50) (show all 87)
# Title Authors PMID Year
1
Pediatric Mastocytosis: An Update. 62
34804443 2021
2
Reflectance confocal microscopy of solitary mastocytoma and correlation with horizontal histopathological sections. 62
32585731 2021
3
Dermoscopic findings of a congenital smooth muscle hamartoma in an infant. 62
31840858 2020
4
Perioperative anaphylaxis in a patient with a solitary mastocytoma. 62
30854701 2019
5
Solitary mastocytoma presenting at birth. 62
29716178 2018
6
Solitary mastocytoma in the eyelid of an adult. 62
29468227 2018
7
Rare cause of recurrent urticaria in childhood and its unusual presentation: Solitary mastocytoma on vulva. 62
27206703 2017
8
Solitary Mastocytoma of the Eyelid in an Adult Patient With Prolidase Deficiency. 62
25603535 2017
9
[Diffuse cutaneous mastocytosis of an infant: A case report]. 62
27670724 2016
10
Solitary mastocytoma presenting in an adult: report and literature review of adult-onset solitary cutaneous mastocytoma with recommendations for evaluation and treatment. 62
27648381 2016
11
Cutaneous form of maculopapular mastocytosis in a foal. 62
27109586 2016
12
Solitary mastocytoma with positive Darier's sign. 62
27057508 2016
13
Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology. 62
26476479 2016
14
Large maculopapular cutaneous lesions are associated with favorable outcome in childhood-onset mastocytosis. 62
26152315 2015
15
Topical corticosteroids versus "wait and see" in the management of solitary mastocytoma in pediatric patients: a long-term follow-up. 62
25471152 2015
16
Solitary mastocytoma mimicking granuloma faciale. 62
25257118 2014
17
Solitary mastocytoma of the vulva. 62
24800094 2014
18
Case Report: Solitary mastocytoma treated successfully with topical tacrolimus. 62
25210620 2014
19
Identification of KIT activating mutations in paediatric solitary mastocytoma. 62
24128084 2014
20
Pediatric Mastocytosis: A Review of the Literature. 62
24380017 2013
21
Solitary mastocytoma of the eyelid. 62
23871296 2013
22
Solitary mastocytoma with associated pseudocarcinomatous hyperplasia. 62
23252514 2013
23
Death from mast cell leukemia: a young patient with longstanding cutaneous mastocytosis evolving into fatal mast cell leukemia. 62
22329485 2012
24
Dermacase: Can you identify this condition? Solitary mastocytoma. 62
22977914 2012
25
Malignant transformation of mastocytoma developed on skin mastocytosis into cutaneous mast cell sarcoma. 62
22498828 2012
26
Solitary mastocytoma in an adult with an unusual clinical presentation. 62
21839341 2011
27
Pathology quiz case 1. Pediatric solitary mastocytoma. 62
21768423 2011
28
Solitary mastocytoma with histologic features of eosinophilic cellulites. 62
21540136 2011
29
[Cutaneous mastocytoma: A brief literature review and report of two cases]. 62
21967973 2011
30
A solitary mastocytoma presenting with urticaria and angioedema in a 14-year-old boy. 62
21708063 2010
31
A 3-month-old with a blistering plaque. 62
20875331 2010
32
A rare presentation of solitary mastocytoma in the palm of an infant. 62
19502121 2010
33
Scabies presenting as solitary mastocytoma-like eruption in an infant. 62
19689539 2009
34
Solitary mastocytoma occurring at a site of trauma. 62
19397569 2009
35
Most common clinical presentations of cutaneous mastocytosis. 62
19623875 2009
36
Solitary mastocytoma: tooth eruption as triggering factor. 62
19126015 2008
37
Cutaneous mastocytosis: a review focusing on the pediatric population. 62
18502981 2008
38
Adult onset, hypopigmented solitary mastocytoma: report of two cases. 62
18187823 2008
39
Flushing and increase of serum tryptase after mechanical irritation of a solitary mastocytoma. 62
17540642 2007
40
A 6-month old with total body flushing and a macular-papular lesion. 62
17505276 2007
41
Midline cutaneous lumbosacral lesions: not always a sign of occult spinal dysraphism. 62
16453111 2006
42
Congenital smooth muscle hamartoma: the importance of differentiation from melanocytic nevi. 62
16192884 2005
43
Solitary mastocytoma. 62
15876605 2005
44
What is your diagnosis? Solitary mastocytoma. 62
15551714 2004
45
A red-brown plaque on the nape. Solitary mastocytoma. 62
15492195 2004
46
Solitary mastocytoma successfully treated with a moderate potency topical steroid. 62
15176167 2004
47
Electron microscopic study in a case of solitary mastocytoma. 62
15222530 2004
48
Flushing due to solitary cutaneous mastocytoma can be prevented by hydrocolloid dressings. 62
15165209 2004
49
Solitary mastocytoma of the vulva: report of a case. 62
14501824 2003
50
Presentation of telangiectasia macularis eruptiva perstans as a long-standing solitary plaque associated with renal carcinoma. 62
14973646 2003

Variations for Solitary Mastocytoma of the Skin

Expression for Solitary Mastocytoma of the Skin

Search GEO for disease gene expression data for Solitary Mastocytoma of the Skin.

Pathways for Solitary Mastocytoma of the Skin

GO Terms for Solitary Mastocytoma of the Skin

Cellular components related to Solitary Mastocytoma of the Skin according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 TPSD1 TPSAB1 SERPINA3 KITLG KIT CMA1
2 extracellular region GO:0005576 9.47 TPSD1 TPSAB1 SERPINA3 KITLG ENPP3 CMA1

Biological processes related to Solitary Mastocytoma of the Skin according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ectopic germ cell programmed cell death GO:0035234 9.62 KITLG KIT
2 embryonic hemopoiesis GO:0035162 9.56 KITLG KIT
3 positive regulation of mast cell proliferation GO:0070668 9.46 KITLG KIT
4 mast cell proliferation GO:0070662 9.26 KITLG KIT
5 melanocyte migration GO:0097324 8.92 KITLG KIT

Molecular functions related to Solitary Mastocytoma of the Skin according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.43 TPSD1 TPSAB1 CMA1
2 serine-type peptidase activity GO:0008236 9.1 TPSD1 TPSAB1 CMA1

Sources for Solitary Mastocytoma of the Skin

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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