MCID: SLT001
MIFTS: 32

Solitary Osseous Plasmacytoma

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Solitary Osseous Plasmacytoma

MalaCards integrated aliases for Solitary Osseous Plasmacytoma:

Name: Solitary Osseous Plasmacytoma 11 14 71
Isolated Osseous Plasmacytoma 11
Solitary Plasmacytoma of Bone 11

Classifications:



External Ids:

Disease Ontology 11 DOID:3722
NCIt 49 C7812
SNOMED-CT 68 42215000
UMLS 71 C0272256

Summaries for Solitary Osseous Plasmacytoma

MalaCards based summary: Solitary Osseous Plasmacytoma, also known as isolated osseous plasmacytoma, is related to plasmacytoma and castleman disease, and has symptoms including bone pain An important gene associated with Solitary Osseous Plasmacytoma is MYOM2 (Myomesin 2), and among its related pathways/superpathways are NF-kappaB Signaling and Dendritic Cells Developmental Lineage Pathway. The drugs Lenalidomide and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin.

Related Diseases for Solitary Osseous Plasmacytoma

Diseases related to Solitary Osseous Plasmacytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 plasmacytoma 31.3 PTPRC NCAM1 CD79A CD38 B2M
2 castleman disease 30.4 SDC1 MYOM2
3 bone lymphoma 30.2 PTPRC CD79A
4 monoclonal paraproteinemia 29.0 SDC1 NCAM1 IGHV4-38-2 CD79A B2M
5 myeloma, multiple 28.7 SDC1 PTPRC NCAM1 MYOM2 CD79A CD38
6 monoclonal gammopathy of uncertain significance 28.6 SDC1 PTPRC NCAM1 MYOM2 IGHV4-38-2 CD38
7 extramedullary plasmacytoma 28.3 SDC1 PTPRC NCAM1 MYOM2 IGHV4-38-2 CD79A
8 plasma cell neoplasm 28.3 SDC1 PTPRC NCAM1 MYOM2 IGHV4-38-2 CD79A
9 short stature, onychodysplasia, facial dysmorphism, and hypotrichosis 10.3
10 cytokine deficiency 10.3
11 amyloidosis 10.2
12 rare tumor 10.2
13 myopathy, lactic acidosis, and sideroblastic anemia 3 10.2 SDC1 MYOM2
14 submucous uterine fibroid 10.2 SDC1 CD38
15 paranasal sinus lymphoma 10.2 SDC1 CD79A
16 acute poststreptococcal glomerulonephritis 10.1 MYOM2 CD79A
17 igg4-related disease 10.1 SDC1 CD38
18 pleural empyema 10.1 SDC1 CD79A
19 pulmonary coin lesion 10.1 MYOM2 B2M
20 sternum lymphoma 10.1 NCAM1 CD79A
21 sternum cancer 10.1 NCAM1 CD79A
22 breast rhabdomyosarcoma 10.1 NCAM1 CD79A
23 hodgkin's lymphoma, lymphocytic depletion 10.1 PTPRC CD79A
24 mediastinal cancer 10.1 NCAM1 CD79A
25 epiglottis neoplasm 10.1 PTPRC CD79A
26 proliferative glomerulonephritis 10.1 MYOM2 CD79A
27 cerebellopontine angle primitive neuroectodermal tumor 10.0 PTPRC NCAM1
28 abducens palsy 10.0
29 meningioma, familial 10.0
30 brain cancer 10.0
31 spinal cord disease 10.0
32 paresthesia 10.0
33 adult type testicular granulosa cell tumor 10.0 PTPRC NCAM1
34 lymphoma 10.0
35 osteomalacia 10.0
36 polyneuropathy 10.0
37 poems syndrome 10.0
38 neuroendocrine tumor 10.0
39 bone cancer 10.0
40 oncogenic osteomalacia 10.0
41 back pain 10.0
42 primary bone lymphoma 10.0
43 endometrial small cell carcinoma 10.0 PTPRC NCAM1
44 prostate neuroendocrine neoplasm 10.0 PTPRC NCAM1
45 b-cell expansion with nfkb and t-cell anergy 10.0 CD38 B2M
46 malignant olfactory nerve neoplasm 10.0 PTPRC NCAM1
47 histiocytic and dendritic cell cancer 10.0 PTPRC CD79A
48 intellectual developmental disorder, autosomal dominant 10 9.9 IGHV4-38-2 CD38
49 intellectual developmental disorder, autosomal dominant 36 9.9 SDC1 PTPRC CD38
50 amebiasis 9.9 IGLL5 CD79A

Graphical network of the top 20 diseases related to Solitary Osseous Plasmacytoma:



Diseases related to Solitary Osseous Plasmacytoma

Symptoms & Phenotypes for Solitary Osseous Plasmacytoma

UMLS symptoms related to Solitary Osseous Plasmacytoma:


bone pain

Drugs & Therapeutics for Solitary Osseous Plasmacytoma

Drugs for Solitary Osseous Plasmacytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenalidomide Approved Phase 3 191732-72-6 216326
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3 3680
3
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 3003 5743
4
Sodium citrate Approved, Investigational Phase 3 68-04-2 23431961
5
Zoledronic acid Approved Phase 3 118072-93-8 68740
6
Ixazomib Approved, Investigational Phase 3 1072833-77-2 25183872
7
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
8 Antineoplastic Agents, Hormonal Phase 3
9 Hormones Phase 3
10 Hormone Antagonists Phase 3
11 Angiogenesis Inhibitors Phase 3
12 Antiemetics Phase 3
13 HIV Protease Inhibitors Phase 3
14 glucocorticoids Phase 3
15 Anti-Inflammatory Agents Phase 3
16 Gastrointestinal Agents Phase 3
17 Immunologic Factors Phase 3
18 Citrate Phase 3
19
protease inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Solitary Plasmacytoma of Bone: Randomized Phase III Trial to Evaluate Treatment With Adjuvant Systemic Treatment and Zoledronic Acid Versus Zoledronic Acid After Definite Radiation Therapy Active, not recruiting NCT02516423 Phase 3 ixazomib;lenalidomide;dexamethasone;zoledronic acid

Search NIH Clinical Center for Solitary Osseous Plasmacytoma

Genetic Tests for Solitary Osseous Plasmacytoma

Anatomical Context for Solitary Osseous Plasmacytoma

Organs/tissues related to Solitary Osseous Plasmacytoma:

MalaCards : Bone, Bone Marrow, Skin, Brain

Publications for Solitary Osseous Plasmacytoma

Articles related to Solitary Osseous Plasmacytoma:

(show top 50) (show all 167)
# Title Authors PMID Year
1
Diagnosing Multiple Myeloma and Related Disorders. 62
36270842 2023
2
Plasma cell neoplasms and related entities-evolution in diagnosis and classification. 62
36414803 2022
3
The Prevalence of Epstein-Barr Virus in Plasma Cell Neoplasms is Higher in HIV-Positive Individuals. 62
35912479 2022
4
Development of Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome after Conversion from Plasmacytoma of Bone to Multiple Myeloma. 62
35831107 2022
5
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours. 62
35312978 2022
6
Multiple myeloma with presentation in the oral cavity. 62
35571327 2022
7
Decrease of CD38 expression is linked to increase of solitary plasmacytoma pathological grade: a single institution experience from China. 62
35090326 2022
8
Prediction of Solitary Plasmacytoma of Bone in Elderly Patients: A Nomogram and a Risk Classification System for Overall Survival. 62
35692586 2022
9
A case of solitary plasmacytoma of bone showing co-expression of both immunoglobulin light chains. 62
34930458 2021
10
Solitary osseous plasmacytomas in dogs: 13 cases (2004-2019). 62
34467522 2021
11
Solitary Plasmacytoma of the Frontal Bone. 62
33108859 2021
12
Case Report: Suspected Solitary Osseous Plasmacytoma in a Cat: Use of Magnetic Resonance Imaging to Diagnose and Confirm Resolution of Disease Following Chemotherapy. 62
34676257 2021
13
Prognostic Nomogram for Predicting Overall Survival of Solitary Bone Plasmacytoma Patients: A Large Population-Based Study. 62
34849007 2021
14
Solitary plasmacytoma of jaw bone: A case report and systematic review of fifty cases from literature. 62
34349446 2021
15
Survival trends and prognostic factors in patients with solitary plasmacytoma of bone: A population-based study. 62
33145987 2021
16
Response and outcome following radiation therapy of macroscopic canine plasma cell tumours. 62
32419347 2020
17
Cranial solitary osseous plasmacytoma and subjacent amyloid deposition in a dog. 62
33363766 2020
18
Clinical presentation and outcomes of solitary plasmacytoma in a tertiary hospital in the UK. 62
32934063 2020
19
Untreated plasmacytoma of bone containing macroscopic intralesional fat and mimicking intraosseous lipoma: A case report and review of the literature. 62
32208179 2020
20
Paraplegia Secondary to Plasmacytoma of the Lumbar Spine. 62
32986578 2020
21
Surgical Resection of Solitary Bone Plasmacytoma of Atlas and Reconstruction with 3-Dimensional-Printed Titanium Patient-Specific Implant. 62
32311548 2020
22
Does Radiotherapy with Surgery Improve Survival and Decrease Progression to Multiple Myeloma in Patients with Solitary Plasmacytoma of Bone of the Spine? 62
31715413 2020
23
Reossification and prognosis following radiotherapy with/without surgery for spinal solitary plasmacytoma of the bone: a retrospective study of 39 patients. 62
31546017 2020
24
Epstein-Barr virus-positive plasmacytoma in immunocompetent patients: a diagnostic dilemma. 62
32269699 2020
25
Clinicopathological spectrum of solitary Plasmacytoma: a single center experience from coastal India. 62
31412808 2019
26
Osteoblastic Solitary Plasmacytoma of Bone 62
30820260 2019
27
Solitary plasmacytoma of mandible: A rare entity. 62
31110430 2019
28
Solitary Plasmacytoma of Bone of the Spine: Results From Surveillance, Epidemiology, and End Results (SEER) Registry. 62
30005040 2019
29
Tonsillar Plasmacytoma: clues on magnetic resonance imaging. 62
29914385 2018
30
Classification of Solitary Plasmacytoma, Is it more Intricate than Presently Suggested? A Commentary. 62
30410592 2018
31
Solitary Giant Extradural Plasmacytoma. 62
29114293 2017
32
Hematopoietic Tumors Primarily Presenting in Bone. 62
28797508 2017
33
Bilateral extramedullary adrenal plasmacytoma: case report and review of the literature. 62
28758008 2017
34
Rare Pedal Manifestation of Diffuse Multiple Myeloma Lesions. 62
28231967 2017
35
Rare Presentation of Primary Extramedullary Plasmacytoma as Lip Lesion. 62
28409043 2017
36
Solitary Plasmacytoma of Bone Involving Spine in a 12-year-old Boy: Report of a Rare Case and Review of Literature. 62
28553386 2017
37
An Incidental Solitary Plasmacytoma of Bone Mimicking Neuroendocrine Tumor Metastasis on 68Ga-DOTATATE Positron Emission Tomography/Computed Tomography. 62
27751979 2016
38
[Solitary plasmacytoma of bone]. 62
30707823 2016
39
Extramedullary Plasmacytoma of the Maxilla Simulating a Maxillary Radicular Cyst: Quick Diagnosis and Management. 62
27054435 2016
40
Solitary plasmacytoma of L3 vertebral body treated by minimal access surgery: Common problem different solution! 62
26566340 2015
41
Proximal femur giant solitary plasmacytoma of bone: lessons learnt. 62
26260956 2015
42
Surgery for plasma cell neoplasia patients with spinal instability or neurological impairment caused by spinal lesions as the first clinical manifestation. 62
25527401 2015
43
A retrospective study of correlation of morphologic patterns, MIB1 proliferation index, and survival analysis in 134 cases of plasmacytoma. 62
25842207 2015
44
Extramedullary plasmacytoma of gingiva and soft tissue in neck. 62
25584334 2014
45
Solitary plasmacytoma of the index finger. 62
24964361 2014
46
Mandibular plasmacytoma of jaw - a case report. 62
25302275 2014
47
Outcome prediction in plasmacytoma of bone: a risk model utilizing bone marrow flow cytometry and light-chain analysis. 62
24939658 2014
48
Gradenigo's syndrome as first presentation of solitary osseous plasmacytoma of the petrous apex. 62
24979569 2014
49
Contribution of surgery in solitary plasmacytoma of spine; a case report. 62
25207332 2014
50
Bcl-2 expression is associated with poor prognosis of solitary plasmacytoma of bone. 62
24013520 2014

Variations for Solitary Osseous Plasmacytoma

Expression for Solitary Osseous Plasmacytoma

Search GEO for disease gene expression data for Solitary Osseous Plasmacytoma.

Pathways for Solitary Osseous Plasmacytoma

GO Terms for Solitary Osseous Plasmacytoma

Cellular components related to Solitary Osseous Plasmacytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.61 SDC1 PTPRC NCAM1 CD38 B2M
2 external side of plasma membrane GO:0009897 9.44 SDC1 PTPRC NCAM1 IGLL5 IGHV4-38-2 CD79A

Biological processes related to Solitary Osseous Plasmacytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell mediated cytotoxicity GO:0001916 9.46 PTPRC B2M
2 B cell proliferation GO:0042100 9.43 PTPRC CD79A CD38
3 B cell receptor signaling pathway GO:0050853 9.28 PTPRC IGLL5 IGHV4-38-2 CD79A CD38

Sources for Solitary Osseous Plasmacytoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....