MCID: SLT001
MIFTS: 31

Solitary Osseous Plasmacytoma

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Solitary Osseous Plasmacytoma

MalaCards integrated aliases for Solitary Osseous Plasmacytoma:

Name: Solitary Osseous Plasmacytoma 12 15 70
Isolated Osseous Plasmacytoma 12
Solitary Plasmacytoma of Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3722
NCIt 50 C7812
SNOMED-CT 67 42215000
UMLS 70 C0272256

Summaries for Solitary Osseous Plasmacytoma

MalaCards based summary : Solitary Osseous Plasmacytoma, also known as isolated osseous plasmacytoma, is related to plasmacytoma and castleman disease, and has symptoms including bone pain An important gene associated with Solitary Osseous Plasmacytoma is MYOM2 (Myomesin 2), and among its related pathways/superpathways are NF-kappaB Signaling and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Dexamethasone and Sodium citrate have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and bone marrow.

Related Diseases for Solitary Osseous Plasmacytoma

Diseases related to Solitary Osseous Plasmacytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 plasmacytoma 31.1 NCAM1 CD79A CD38 B2M
2 castleman disease 30.3 SDC1 MYOM2
3 proteinuria, chronic benign 30.0 CD79A B2M
4 monoclonal paraproteinemia 29.8 SDC1 NCAM1 CD79A
5 plasma cell neoplasm 29.8 SDC1 MYOM2 B2M
6 extramedullary plasmacytoma 29.0 SDC1 MYOM2 CD79A CD38 B2M
7 myeloma, multiple 28.7 SDC1 NCAM1 MYOM2 CD38 B2M
8 monoclonal gammopathy of uncertain significance 28.7 SDC1 NCAM1 MYOM2 CD38 B2M
9 cytokine deficiency 10.3
10 rare tumor 10.2
11 glomeruloid hemangioma 10.2 SDC1 MYOM2
12 heavy chain disease 10.1 MYOM2 CD79A
13 alpha chain disease 10.1 MYOM2 CD79A
14 acute poststreptococcal glomerulonephritis 10.1 MYOM2 CD79A
15 pleural empyema 10.1 SDC1 CD79A
16 amyloid tumor 10.1 MYOM2 B2M
17 gastrointestinal lymphoma 10.1 NCAM1 CD79A
18 mediastinal cancer 10.0 NCAM1 CD79A
19 breast rhabdomyosarcoma 10.0 NCAM1 CD79A
20 abducens palsy 10.0
21 amyloidosis 10.0
22 exophthalmos 10.0
23 paresthesia 10.0
24 osteomalacia 10.0
25 polyneuropathy 10.0
26 neuroendocrine tumor 10.0
27 bone lymphoma 10.0
28 oncogenic osteomalacia 10.0
29 back pain 10.0
30 primary bone lymphoma 10.0
31 marginal zone b-cell lymphoma 10.0 SDC1 CD79A
32 hyperpigmentation with or without hypopigmentation, familial progressive 10.0 IGLL5 CD79A
33 amebiasis 10.0 IGLL5 CD79A
34 myeloid sarcoma 10.0 NCAM1 CD79A
35 nasal cavity lymphoma 10.0 NCAM1 B2M
36 mineral metabolism disease 10.0 MYOM2 B2M
37 mature t-cell and nk-cell lymphoma 9.9 NCAM1 CD79A
38 gamma heavy chain disease 9.9 SDC1 CD38
39 syphilis 9.9 CD79A B2M
40 mental retardation, autosomal dominant 36 9.9 SDC1 CD38
41 mental retardation, autosomal dominant 10 9.9 SDC1 CD38
42 meningoencephalitis 9.9 CD79A B2M
43 nasal cavity benign neoplasm 9.9 SDC1 NCAM1 MYOM2
44 spherocytosis, type 5 9.9 SDC1 CD38
45 mulchandani-bhoj-conlin syndrome 9.9 SDC1 CD38
46 membranous nephropathy 9.9 CD79A B2M
47 cll/sll 9.8 CD79A CD38
48 schuurs-hoeijmakers syndrome 9.8 IGLL5 CD38
49 sjogren syndrome 9.8 CD79A B2M
50 small cell cancer of the lung 9.8 NCAM1 B2M

Graphical network of the top 20 diseases related to Solitary Osseous Plasmacytoma:



Diseases related to Solitary Osseous Plasmacytoma

Symptoms & Phenotypes for Solitary Osseous Plasmacytoma

UMLS symptoms related to Solitary Osseous Plasmacytoma:


bone pain

Drugs & Therapeutics for Solitary Osseous Plasmacytoma

Drugs for Solitary Osseous Plasmacytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
2
Sodium citrate Approved, Investigational Phase 3 68-04-2
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
4
Ixazomib Approved, Investigational Phase 3 1072833-77-2
5
Zoledronic Acid Approved Phase 3 118072-93-8 68740
6
Lenalidomide Approved Phase 3 191732-72-6 216326
7
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
8 Angiogenesis Inhibitors Phase 3
9 Citrate Phase 3
10 Gastrointestinal Agents Phase 3
11 Hormone Antagonists Phase 3
12 Hormones Phase 3
13 Antineoplastic Agents, Hormonal Phase 3
14 Antiemetics Phase 3
15
protease inhibitors Phase 3
16 glucocorticoids Phase 3
17 Immunologic Factors Phase 3
18 Anti-Inflammatory Agents Phase 3
19 HIV Protease Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Solitary Plasmacytoma of Bone: Randomized Phase III Trial to Evaluate Treatment With Adjuvant Systemic Treatment and Zoledronic Acid Versus Zoledronic Acid After Definite Radiation Therapy Active, not recruiting NCT02516423 Phase 3 ixazomib;lenalidomide;dexamethasone;zoledronic acid

Search NIH Clinical Center for Solitary Osseous Plasmacytoma

Genetic Tests for Solitary Osseous Plasmacytoma

Anatomical Context for Solitary Osseous Plasmacytoma

MalaCards organs/tissues related to Solitary Osseous Plasmacytoma:

40
Bone, Skin, Bone Marrow

Publications for Solitary Osseous Plasmacytoma

Articles related to Solitary Osseous Plasmacytoma:

(show top 50) (show all 154)
# Title Authors PMID Year
1
Solitary Plasmacytoma of the Frontal Bone. 61
33108859 2021
2
Survival trends and prognostic factors in patients with solitary plasmacytoma of bone: A population-based study. 61
33145987 2021
3
Cranial solitary osseous plasmacytoma and subjacent amyloid deposition in a dog. 61
33363766 2020
4
Response and outcome following radiation therapy of macroscopic canine plasma cell tumours. 61
32419347 2020
5
Clinical presentation and outcomes of solitary plasmacytoma in a tertiary hospital in the UK. 61
32934063 2020
6
Untreated plasmacytoma of bone containing macroscopic intralesional fat and mimicking intraosseous lipoma: A case report and review of the literature. 61
32208179 2020
7
Paraplegia Secondary to Plasmacytoma of the Lumbar Spine. 61
32986578 2020
8
Surgical Resection of Solitary Bone Plasmacytoma of Atlas and Reconstruction with 3-Dimensional-Printed Titanium Patient-Specific Implant. 61
32311548 2020
9
Does Radiotherapy with Surgery Improve Survival and Decrease Progression to Multiple Myeloma in Patients with Solitary Plasmacytoma of Bone of the Spine? 61
31715413 2020
10
Reossification and prognosis following radiotherapy with/without surgery for spinal solitary plasmacytoma of the bone: a retrospective study of 39 patients. 61
31546017 2020
11
Epstein-Barr virus-positive plasmacytoma in immunocompetent patients: a diagnostic dilemma. 61
32269699 2020
12
Clinicopathological spectrum of solitary Plasmacytoma: a single center experience from coastal India. 61
31412808 2019
13
Osteoblastic Solitary Plasmacytoma of Bone 61
30820260 2019
14
Solitary Plasmacytoma of Bone of the Spine: Results From Surveillance, Epidemiology, and End Results (SEER) Registry. 61
30005040 2019
15
Solitary plasmacytoma of mandible: A rare entity. 61
31110430 2019
16
Tonsillar Plasmacytoma: clues on magnetic resonance imaging. 61
29914385 2018
17
Classification of Solitary Plasmacytoma, Is it more Intricate than Presently Suggested? A Commentary. 61
30410592 2018
18
Solitary Giant Extradural Plasmacytoma. 61
29114293 2017
19
Hematopoietic Tumors Primarily Presenting in Bone. 61
28797508 2017
20
Bilateral extramedullary adrenal plasmacytoma: case report and review of the literature. 61
28758008 2017
21
Rare Pedal Manifestation of Diffuse Multiple Myeloma Lesions. 61
28231967 2017
22
Rare Presentation of Primary Extramedullary Plasmacytoma as Lip Lesion. 61
28409043 2017
23
Solitary Plasmacytoma of Bone Involving Spine in a 12-year-old Boy: Report of a Rare Case and Review of Literature. 61
28553386 2017
24
An Incidental Solitary Plasmacytoma of Bone Mimicking Neuroendocrine Tumor Metastasis on 68Ga-DOTATATE Positron Emission Tomography/Computed Tomography. 61
27751979 2016
25
[Solitary plasmacytoma of bone]. 61
30707823 2016
26
Extramedullary Plasmacytoma of the Maxilla Simulating a Maxillary Radicular Cyst: Quick Diagnosis and Management. 61
27054435 2016
27
Solitary plasmacytoma of L3 vertebral body treated by minimal access surgery: Common problem different solution! 61
26566340 2015
28
Proximal femur giant solitary plasmacytoma of bone: lessons learnt. 61
26260956 2015
29
Surgery for plasma cell neoplasia patients with spinal instability or neurological impairment caused by spinal lesions as the first clinical manifestation. 61
25527401 2015
30
A retrospective study of correlation of morphologic patterns, MIB1 proliferation index, and survival analysis in 134 cases of plasmacytoma. 61
25842207 2015
31
Extramedullary plasmacytoma of gingiva and soft tissue in neck. 61
25584334 2014
32
Solitary plasmacytoma of the index finger. 61
24964361 2014
33
Mandibular plasmacytoma of jaw - a case report. 61
25302275 2014
34
Outcome prediction in plasmacytoma of bone: a risk model utilizing bone marrow flow cytometry and light-chain analysis. 61
24939658 2014
35
Gradenigo's syndrome as first presentation of solitary osseous plasmacytoma of the petrous apex. 61
24979569 2014
36
Contribution of surgery in solitary plasmacytoma of spine; a case report. 61
25207332 2014
37
Bcl-2 expression is associated with poor prognosis of solitary plasmacytoma of bone. 61
24013520 2014
38
Solitary plasmacytoma of the sternum. 61
24368980 2013
39
Solitary plasmacytoma of skull: a rare cytological diagnosis. 61
24086882 2013
40
Solitary plasmacytoma of the medial clavicle. 61
23710481 2013
41
Multiple cytokine-producing plasmablastic solitary plasmacytoma of bone expressing multiple cytokine receptors. 61
22971174 2013
42
Nasal septum extramedullary plasmacytoma. 61
23607192 2013
43
[Current technologies in radiotherapy for non-Hodgkin lymphomas]. 61
24032229 2013
44
[Modern imaging techniques in patients with multiple myeloma]. 61
23196838 2013
45
Radiotherapy for solitary plasmacytoma of bone and soft tissue: outcomes and prognostic factors. 61
22752147 2012
46
Primary isolated extramedullary plasmacytoma of mesentry: a rare case report. 61
22773223 2012
47
Trends and outcomes of modern staging of solitary plasmacytoma of bone. 61
22549792 2012
48
A rare differential diagnosis for cause of proptosis: skull plasmacytoma. 61
24028993 2012
49
Pathological bone fractures in a 20-year old athletic male with multifocal solitary plasmacytoma of bone. 61
22213270 2012
50
Multiple cytokine-producing plasmablastic solitary plasmacytoma of bone with polyneuropathy, organomegaly, endocrinology, monoclonal protein, and skin changes syndrome. 61
22231043 2012

Variations for Solitary Osseous Plasmacytoma

Expression for Solitary Osseous Plasmacytoma

Search GEO for disease gene expression data for Solitary Osseous Plasmacytoma.

Pathways for Solitary Osseous Plasmacytoma

Pathways related to Solitary Osseous Plasmacytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 NCAM1 CD79A CD38 B2M
2 11.31 SDC1 NCAM1 CD79A
3 11.13 NCAM1 CD38
4 10.99 SDC1 NCAM1 CD79A CD38

GO Terms for Solitary Osseous Plasmacytoma

Cellular components related to Solitary Osseous Plasmacytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 SDC1 NCAM1 CD38 B2M
2 external side of plasma membrane GO:0009897 9.02 SDC1 NCAM1 IGLL5 CD79A B2M

Biological processes related to Solitary Osseous Plasmacytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interferon-gamma-mediated signaling pathway GO:0060333 9.16 NCAM1 B2M
2 negative regulation of neuron projection development GO:0010977 8.96 CD38 B2M
3 B cell receptor signaling pathway GO:0050853 8.8 IGLL5 CD79A CD38

Molecular functions related to Solitary Osseous Plasmacytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 SDC1 NCAM1 CD79A CD38 B2M

Sources for Solitary Osseous Plasmacytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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